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Query: [K] COG1510 Predicted transcriptional regulators, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNRKPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISLFAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLSRLIEFFESEEVFRYVPKTKECSSLKLast
1 -71.600[K] COG1510 Predicted transcriptional regulators  ali  100  1MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNRKPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISLFAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLSRLIEFFESEEVFRYVPKTKECSSLK 185
2 -22.700[K] COG5625 Predicted transcription regulator containing HTH domain  ali follow..  12  2...........KQEEMLKKLEDLLKAIGLKKNEIRIYRLLVEKRRGMRIREIQRELGISERSVRTHVLNLYRRGLLKRELVQSGWLGYYTPVS---LEILQKIKEHLMKSIEELERDLKNQTRS............................................................. 113
3 -22.700[K] COG3355 Predicted transcriptional regulator  ali follow..  12  4.......KVRFPDGREVDIHDFIAFMYGLSKSDVEVLHILL-QNGKMTTDDLSQKLNVTKASISKALNNLLDKGLIQREKAPAEKEERKGRPNYIYWVEKERLYRKLEADLEKLAGTVKEALQK............................................................. 119
4 -19.400[K] COG1846 Transcriptional regulators  ali follow..  12  19.......RLILQLRRLESTPRTFGRAGALTPSEIHTIDAI--TDEGLLMKELAERLGVTKGAVSQLVDRLEAKALVRRTAHPKVSRGIQVVLTDKGREAYRAHADMHAAFYEELQQSFTK-------------------EEIAIFEQCVSKLRDILSE........................... 149
5 -18.200[K] COG4738 Predicted transcriptional regulator  ali follow..  13  10ISEENDFKMGEVEYEMVELL----RRLNINRPVALTLACL-SKGDEISSQRIEMVSGLRQPEVSIAMRYLRENEWVDMREEKGRPVKLYKLTVQM-ETIIDTIEENVIAESKTILQNIERLKS.............................................................. 131
6 -17.900[K] COG5631 Predicted transcription regulator, contains HTH domain (MarR family)  ali follow..  11  60.......LASHAFSRWMVRCMAAAGLPGLSPIEILILHSIRHRDREKKLADICLALDIETHIATYAIRKLEKAGLLTT---GKAAKEKTVKITAKGAEACAHYAQIRERLLVDSTANARPSEETLSELAALLRFMSGAFNQATRSAITL.................................... 199
7 -15.400[K] COG1777 Predicted transcriptional regulators  ali follow..  13  1...............MIDDIDNFIAAIE-NSTRREIIRML-TQFERSYALELSRSIGLSQQAILKQLEMLERANLVTSIGFVPSSRKLYEPTGFSTLIV-NFLMIQRIPLENDSERVSVSFDEAISKLESIQHHIEELTKKRTELVKKKDELMAAIKYQLEDEDPITREIVLEYLNTFDVEE... 172
8 -14.700[K] COG1497 Predicted transcriptional regulator  ali follow..  8  14..................................QILSEIAMRQPYVRQKDIADKLGVTVQAVSENIKSLIAEGLVESG----SGRSHYKITRRGAEKIKEAA-MDLRRYADEVLESMSFYRSVWPAIAWE...................................................... 105
9 -14.100[K] COG1378 Predicted transcriptional regulators  ali follow..  14  23................MDEIIEVLKRLGFRDYEARVYATL-ATRGEATASEIHRVSGVPRNKVYEVLRSLEDRGMIETIK---SSPAVFRAID---ESVLEEYKEQLVSAVDTAIRSIRESEDFSTL.......................................................... 127
10 -13.500[KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon  ali follow..  15  1............................MKMKTLFLLIKLA-KEITVTMRELSRELDVSPQTVLRWLEELKEQGYIHKRESRKGTL................................................................................................... 63
11 -13.400[K] COG2345 Predicted transcriptional regulator  ali follow..  15  15.............................GDTRRKILLIL--ERAPVIASDIAEQLQLSTVGVRRHLDNLVEENLAEAANPRQNPYE----PAKTYRLTDKGRSIFGHEYDSLAAAALATLREVGGDDAVRQFARKRIETIVEGITPADVTDQSIEDTAKSLVEAFSR................. 154
12 -13.300[K] COG0640 Predicted transcriptional regulators  ali follow..  12  1................................................MNEITMQTQADQPKVSSNLAILSEARLVD-SIQMG-REKIYRIAPEKFEDMVDWLDS................................................................................ 55
13 -13.300[S] COG2512 Uncharacterized membrane-associated protein/domain  ali follow..  18  246............................LSPELCEVLDIIRGHKGRITQKDLRSKLDYSEVKVSLMLSELEKRGLIRKLRN-G-RENILVLVDE........................................................................................... 309
14 -13.200[S] COG3398 Uncharacterized protein conserved in archaea  ali follow..  20  185.............................NATNQRIISEI-QNGKCNTNLALAREIGVSRATISWYVKNLKETGLIDETRS--GRSIIYSINPSYEPLIEK.................................................................................... 253
15 -12.400[S] COG4519 Uncharacterized protein conserved in bacteria  ali follow..  18  3............................LSPVFARRLYLAVESLERPNVPKLIEKTGWPRRTIQDVIKAMPGIGIELNFVQDGRRH................................................................................................... 62
16 -12.300[K] COG4190 Predicted transcriptional regulator  ali follow..  12  67............................LTPRVLELIEAI-RQEEPASINETARVVDRDVKNVHEELSRLAHLGIIFF--EEDGQRKRPVVWFD........................................................................................... 129
17 -12.300[K] COG4742 Predicted transcriptional regulator  ali follow..  14  9............................VFRSQKRRDLLLLLGEEPRTMEDIKVLLDVSPTAILPQIKRLTDSNLVIQ........................................................................................................... 58
18 -12.000[S] COG3373 Uncharacterized protein conserved in archaea  ali follow..  10  8.....................NILRSLNRSELRRKVLFYLLIYPYRSYLSEISRAVKSDPSNVKGCLESLIGLGLVIV--EQSKNGFKYFKINPEIVEEVRNMKNMFSDKKVYTVE..................................................................... 111
19 -11.700[K] COG4189 Predicted transcriptional regulator  ali follow..  11  1MAPNFLLVDAEKEFDVLKAAA--------SLIRVQILKLL-HEANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRKARKKICFATCDELIVSFRKPETPAASNYIA......................................................................... 106
20 -11.600[K] COG3432 Predicted transcriptional regulator  ali follow..  6  40...................................MFDILRNCEPKCGITRVIYGAGINYVVAQKYLDQLVKVGALNI--KTENDRKIYEITEKGKLLR--THIEEFIKIRENLYSAKEKVSELLRTDSE....................................................... 130
21 -11.300[K] COG1695 Predicted transcriptional regulators  ali follow..  14  5..................................AIKALVLLSKKPRTLYQMSKEISVSHGTLMPMIRKLLQERYID--FETRGREKVYHL-TERGSRFVESLGKIEEDVKQNLISRTMGDAFFYLNLLSKNDTSEAIKSAIQILLPAIIAQVEYAFRMLMEGHREEVEGVARDLLRKYGEIDDE 156
22 -11.200[K] COG1414 Transcriptional regulator  ali follow..  12  1MREPTLETDDRYRAPALDK---------------DILELLASVDGGLTQAEIAKHLDRSPNEFYRMLDRLVKRGYVTK-----LDGDRYSLTLKLFG--LAQLHAPVRRLASFATPFMRELADRSKQA......................................................... 108
23 -11.100[S] COG4861 Uncharacterized protein conserved in bacteria  ali follow..  8  82LHPSSAETLRARGLWYIDGAGNLIDVRGFTPKRAQVVCVLLDAPQDAPLRAIAASAGVSVGMAKETMDTLRTTGFFEH........................................................................................................... 194
24 -10.600[T] KOG4603 TBP-1 interacting protein  ali follow..  11  10.............................AGAAGILLRYLQEQNRPYSSQDVFGNLGLGKAVVVKTLEQLAQQGKI--KEKMYGKQKIYFADQDQFDMVSDADLQVLDGKIVALTAKVQSLQQSCRYMEAELKTTPEMQKEIQELKKECAGYRERLKNIKAATNHVTPEEKEQV........... 162
25 -10.400[S] COG3132 Uncharacterized protein conserved in bacteria  ali follow..  10  5............................LTALEARVIGCLLEKQ-PLSVNGVVTAMNLSESEVQEQLDNLVKRHYLRTVSGFGNRVTKYE----------QRFCNSEFGDLKLSAAEVALITTLLLRGAQTPGELRSRAARMYE----FSDMAEVELTLEQLANR-EDGPFVVRLAREPGKRESR 162
26 -10.400[K] COG1802 Transcriptional regulators  ali follow..  15  18............................ENVLRQAIMSGRFTPGERLIERELCETLGVSRTSIREALRRLEAEKLVSIVPHKGEAAELFALRGLLEGFAAREFAQRATVAIVHFAQAIQALRMAGMT.......................................................... 126
27 -10.400[S] COG2469 Uncharacterized conserved protein  ali follow..  9  174.....ETTMDMLQEYIQNFIEKSKPKEKLSEVEEQILTMVY---TGVDSVSVESILGVTTEELNKMYDRLVNLGLARVVKIRKE..................................................................................................... 249
28 -10.100[S] COG4860 Uncharacterized protein conserved in archaea  ali follow..  10  12.................GELVSIFHAAD-SEVKRKLLLDL--STGWITLPVIEQKYG---KEGRRALLYLDKIKMIETQWITGQNEKAYHTYYTNVQINIMGSLSELADIIYAATLSDEQLSE.............................................................. 113
29 -10.000[K] COG1321 Mn-dependent transcriptional regulator  ali follow..  11  2.....VLMHTDRIEEYLET----------------ILYLITKNQGPAKTKQIAEELNVSSPSVTEMIKKLHSMGFVEYKPYQGVE-------TEKGAEEAVRIKRKHQVLETFLADVLDFDRKEAHREACELEVSDSVLERLYDFLGN..................................... 124
30 -9.840[K] KOG2587 RNA polymerase III (C) subunit  ali follow..  9  365.......DYKSIISVAQKDEAVVMRRYG--KEAFRMFRYLSQEGRFVETDKIADAALTEKKDTPQFLLKMWKDGYLQKLAVTAPGTPFLLWKVNK-LIVTTQMLDEMYHASLNLSLRLAHELEAEKELLLLPLLEGPLKERLKKVKAKRLLLSSTMFKLDDAIMLFHD................. 528
31 -9.690[P] COG0735 Fe2+/Zn2+ uptake regulation proteins  ali follow..  10  1.......................MVTPQLTKNQSLVMGALAHSDGPMSAYTILDKLRDNPLQVYRALDKLLEYGLVHRL.......................................................................................................... 60
32 -9.660[S] COG4344 Uncharacterized protein conserved in archaea  ali follow..  7  1................MSEYEKEIDELINDYDMLRVLKHF--IAHVDYAKNITRYTEIPQMRVREYLKRLKDLGLLDYYTEVHKHHTYYQINKKAEAVLKEITPKLYVHHLKSADLQMLCSRKERKENPEA...................................................... 129
33 -9.450[K] COG1654 Biotin operon repressor  ali follow..  19  13.......................................LLADGEFHSGEQLGERLGMSRAAINKHIQTLRDWGVVFTVPGKGYS.................................................................................................... 59
34 -9.340[S] COG3388 Uncharacterized protein conserved in archaea  ali follow..  20  22..................................SVINVL--REQPIGIIKLSQETGIPEHKIRYSLRILEQENIISPS.......................................................................................................... 65
35 -9.330[K] COG1675 Transcription initiation factor IIE, alpha subunit  ali follow..  12  1MKAETTTGVEELLNELVGRAAG----------EVGLILFSLGIEGEFTDDQLSLELGIEINEIRKALFALYEIGLADRDDETGWMEYYWRINYDKALDVLKRELEKTAKKLREKIE..................................................................... 110
36 -9.220[T] COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases  ali follow..  11  152LLSIGRRTAIERAAYLIAFLYRKAKAANLLPGETPI---------PVTQQHVADTLGLSIVHTNKTLRKLVDRGLIR............................................................................................................ 219
37 -9.190[K] COG1733 Predicted transcriptional regulators  ali follow..  16  1MSQHGYKQFCPLSMAA--------------EVLCTRWTMVLMREGSTRFNDLRRGVKMSPTLLSQRLKELELAGIVERKEVPGEGIFDYRLTE............................................................................................ 84
38 -9.020[L] COG3335 Transposase and inactivated derivatives  ali follow..  9  1MPMGRPKVLSEDEQTQLAGMVRSRSIPAALVMRARL---VLAAAAGEPNSEIAERLQLTRATVGKWRARFLERRILYDELRPGKPRTI................................................................................................. 90
39 -9.020[K] COG1522 Transcriptional regulators  ali follow..  12  1.......................MSKVELDKIDRKILEVL--SNGRLTNLEVAERVNLSPSPCLRRIRRLEESGVIRQ........................................................................................................... 54
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.