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Query: [H] COG1541 Coenzyme F390 synthetase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MYWNPAIERLNAKELEEIQERKLKALVSTVYQYSPFYRQRFREAGVTPDDIKSLNDLPKLPFTKKQDLRDTYPFGMFCVPLSQVVRFHASSGTTGKPTVVGYTANDIRNWVESLCRALVSCGVSSDDIMQIAYGYGLFTGGLGFHYAAERLGATVLPISAGNTARQIELMKDLGSTVMACTPSYMIYLAEYASQMGVDIAEDTNLRAGIFGAEPWSEETRKRIEDKTGITAYDVYGTSELSGPLFTECTERQGLHIWADMFLIEIIDPKTGEQVGEGEKGELVVTTLTKEALPLIRWRTGDITYMETDKCACGRTHPRIMRILGRADDMLIIRGVNVFPSQIEHVLMQIPEVGEHYMIIVDRREDGLDELTVQVELSDKAEIDTTGDILKLEKKIADKLKSVLNVWAKVEVVNPGTLQRFEGKAKRVIDRRKILast
1 -126.000[H] COG1541 Coenzyme F390 synthetase  ali  100  1MYWNPAIERLNAKELEEIQERKLKALVSTVYQYSPFYRQRFREAGVTPDDIKSLNDLPKLPFTKKQDLRDTYPFGMFCVPLSQVVRFHASSGTTGKPTVVGYTANDIRNWVESLCRALVSCGVSSDDIMQIAYGYGLFTGGLGFHYAAERLGATVLPISAGNTARQIELMKDLGSTVMACTPSYMIYLAEYASQMGVDIAEDTNLRAGIFGAEPWSEETRKRIEDKTGITAYDVYGTSELSGPLFTECTERQGLHIWADMFLIEIIDPKTGEQVGEGEKGELVVTTLTKEALPLIRWRTGDITYMETDKCACGRTHPRIMRILGRADDMLIIRGVNVFPSQIEHVLMQIPEVGEHYMIIVDRREDGLDELTVQVELSDKAEIDTTGDILKLEKKIADKLKSVLNVWAKVEVVNPGTLQRFEGKAKRVIDRRKI 433
2 -26.600[I] KOG1176 Acyl-CoA synthetase  ali follow..  18  124.........NTASEILRQIADSNPKLAFTTPELAPKIASSGISIVLERVEDTLRVPRGLKVVGNLTEMMKKEPSGRNQVHKDDTAMLLYSSGTTGRSKGVNSSHGNL---IAHVARYIAEPFEQPQQTFICTVPLFHTFGLLNFVLATLALGTTVVILPRFDLGEMMAAVEKYRATTLILVPPVLVTMINKADQI-MKKYDVSFLRTVRCGGAPLSKEVTQGFMKKYTVDVYQGYALTESNGAGASESRRYGAVGLLSCGVEARIVDPNTGQVMGLNQTGELWLKG------PSIALKTGDLCYIDND-------------IVDRLKELIKYKGYQVPPAELEALLLNHPDILDAAVI........................................................................... 478
3 -26.300[IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II  ali follow..  16  85................TAGVKGLTSAITAAEIKTIFTSRQFLD---KGKLWHLPEQLTQVRWVYLEDLKADPRLAQVKQQPEDAAIILFTSGSEGHPKGVVHSHKSI---LANVEQIKTIADFTANDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYSPLHYRIVPELVYDRNCTVLFGTSTFLGNYARFANPYDFY-----RLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAGRIL--PGMDARLLAVPG-----IENGGRLQLKG--ENSRGETEYDTGDIVRFDEN----------FVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSADKMHATAIKSDASKGEALVLFTT--------DSELTREKLQHYAREHGIPELAVPRDIRYL--KQLPLLSGK----PDFVTL 504
4 -25.800[Q] COG1021 Peptide arylation enzymes  ali follow..  15  106................SHQRTELNAYAMQIAPTLVIADRQHTLFAGEDFLNTFVAEHRSVRVVDAAMRQAAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSNEIC---GFNEDTRFLCAIPAHNYAMSSPGALGVFLAKGTVVLATDPSATLCFPLIEKHQINATALVPPAVSLWLQAIQEW-GGNAPLASLRLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSPEGRPMCPDD--VWVADAD-GNPLPPGEIGRLMTSAFDANGF----YCSGDLISIDQD------------TVHGREKDQINRGGEKIAAEEIENLLLRHPVVIHAALVSMEDELLG-EKSCAYLVVKEPLRAVQVRRFLREQGVAEFKLPDRVECVASLPLTPVGKVDKKQLRQR........ 529
5 -25.700[I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases  ali follow..  16  203.............ALKQEVDKALEHGAPSV-ENVIVVQRTKADVTMTAGRDHWWHELQP---------QQSAHCPAEPIDSEDMLFILYTSGSTGKPKGVVHTTGGYNLYTHMTTKWI--FDLKDTDVYWCTADVGWITGHSYIVYGPLSNGATTVMYEGVNPGCFWDVIERYGVNIFYTAPTAIRAFIRMGEAV-PNARDLSSLRLLGTVGEPINPEAWMWYHRVIGCPIVDTWWQTETGGIMLTPLPGAIPTKPGS--IVAEIVD-LDGNPVESDQGGFLVIK----QPWPSM-YFAGDGARRDKD-------------VMGRVDDVINVSGHRLGTMEIESALVSHPLVAEAAVVGRPDELTG-EAIFAFVSLEGNAEPSE-----ELKKDLVKHVTEEIGIARPAEIRFTDVLPKTSGKIMRRLLRSLA 629
6 -23.700[I] KOG1175 Acyl-CoA synthetase  ali follow..  16  234....KTINLKAIVDAALDQSSKDGVSVGICLTYDNSLATTRENTKWQNGRDVWWQDVIS---------QYPTSCEVEWVDAEDPLFLLYTSGSTGKPKGVLHTTGGYMIYTATTFKYA--FDYKSTDVYWCTADCGWITGHSYVTYGPMLNGATVVVFEGADPGRCWDIVDKYKVSIFYTAPTLVRSLMRDDDK--VTRHSRKSLRVLGSVGEPINPSAWRWFFNVVGCPISDTWWQTETGGFMITPLPGAWPQKPGS--VQPVIVD-EKGNEIEGECSGYLCVK----GSWPGA-YFSGDGCSRDKD-------------LTGRVDDVINVSGHRIGTAEVESALVLHPQCAEAAVVGIEHEVKG-QGIYAFVTLLEGVPYSE-----ELRKSLVLMVRNQIGFAAPDRIHWAPGLPKTSGKIMRRILRKIA 665
7 -21.800[Q] KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes  ali follow..  14  105................IWSQQVVRVLVKRLNISDLLYHEYKPKFEVDTLNATSLASLPL----------DIDAPCIRAGLEPEVALINHSSGSTGVPKSMPFLMKKYALGYDYGTPEF---MNHLSTPMVMATSFALTTLSWINALYCNGNLLYPSSSISATCTSEAERLLRAGCERLIILPNLLVLTLQIMPDKEECFP---ACKLVAAGGEMVPANMYHTCKRVLNATIYPQYGTTESGLVSFLAYNGKDTLHNKELVYFP-VTEDNEAVPEKIGCEGFVCVVTVGDDAETIQSVRFADLAVWNS-------------TIKGRLGRRVKRNGVFFDLKYFDQVVVGLKEVKDAFSFFIFNR-----FVLVYVPAYNGVDPVT------LKQKLNKELRDHH---LFSSCFPLADIPRNAGK----VDLKSI 518
8 -19.500[I] KOG1179 Very long-chain acyl-CoA synthetase/fatty acid transporter  ali follow..  12  159................NLRRDALLHCLTTSRARALVFGSEMASA---CEVHASPDPSLSLFCSGSWE-APKHLPSCPDKGFTDKLFYIYTSGTTGLPKAAIVVHSRYYRMAALVYYGF---RMRPNDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYIGELCRYLLNQPPR---EAENQHQVRMALGNA--SGSPSGPTFPAASTYPWLSSTGPECNCSLGNFDSQVGARLVRVNEDTMELIRGPDGVCPCQPGEPGQLVGRNQGANNKKIAKYLTGDVLVMDEL----GYLY-----FRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVEVPGTE-GRAGMAAVASPTGNCDLERFAQVLEKELPLARPIFLRLLPELHKTGTYKFQKTELRKEAF...... 605
9 -17.500[Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins  ali follow..  16  536................RYPADRIEFIAADADLALILVTTENDI--------STIGQNFRCMTPGMVENLAGGAVPTPVTSGADLAYLIYTSGSTGRPKGVAIEHRNAVAFMQWCMHAF---TKDQLSGVLASTSICFDLSIFEIFATLAAGGRIFM---VDDLFAFPSAPFAGEVTLVNTVPTPMSELLKLGPLPQ-------NVKTVCLAGEPLPRELVARIYANDVECLYNLYGPSEDTTYSTVAPVPPSGVPIANTRAY--VLDGEM-NEVPVGVPGELFLTAERFLPNPFADYQTGDIVRRRDD----GG------DYMGRADRQLKLNGFRIEPGEIEAVLLQQEGVHEA-VAGLWRDAANHPRLAMWIAGDPALEITK------LVATLRQRLPEHF---IPVLATRLDALPRLNGK----LDRSAL 935
10 -17.500[I] COG1022 Long-chain acyl-CoA synthetases (AMP-forming)  ali follow..  13  117..........SESKILIVGKLDDNKATAHVLAERPNLISISLPYPSAAKCQYEFQTLIK---------QHQPSEERPTHFDEKLMSIVYTSGTSGQPKGAMLTYGAFTWSAQQLINHI---GIEENDRLFSYLPLAHITERVYIFGSSIIGGVLTA---PESLDTFIEDVKMHRPTLFISVPRLWTLFQQRIQDKLPQKKLNIQARVLGCGSAPVSPALLEWYRSV-GLNITEAWGMTESFAYSTLNYPF-------RADKIGTVGNAGPGIELKIAEDEEILVESFNDDGW----LHTGDIGSLDSE------------TIQGRKKDTFKTKGKFVAPVPIEKKLFEYSRVEMMCLI-----GSGLPAPILLAVPHNFPHFDRARYERTTQKVIAEQIKGVLMIKDPWSIDNGILTPTLKIKRHVLEKK... 545
11 -16.800[I] KOG1256 Long-chain acyl-CoA synthetases (AMP-forming)  ali follow..  14  187..........CEISLMFVDAEIKTKQLIRDKSYLSSLKYIVQFNECS-DDIKEMARENDFRLWSFNEFKKQKHRPHVPPTPETLATISFTSGTTGRPKGVMLTHLNMCSATMSCEEFENE--AGVQDAYLSYLPLAHIYERLCLLSNFMI---SRIGFSRGDPKLLVDDVQALAPRSFATVPRVIDKIHKAVMKHKIQMLLGPNIRQLILGAAKSDVSAMRFARGAFGVEVLEGYGQTETSGPTTLQLVGDGCVGPPMACAMIKLIDVPELGYSVDKNGGEVLVSSFTEDGY----MKTGDIGRFTAE----GS------QIIDRRKNVFKMQGKFVAPDLTESLYTSSSFVQQIYVHIVVPDPEYLASYALTKHNINGKTYEQLCNIPILADDVLRQFVELTEEDKRPRYEGVYGV-TPTLKNKRNAIAQFF 679
12 -14.800[I] KOG1180 Acyl-CoA synthetase  ali follow..  15  208..........VGAKTIFTSEALISKVKKAMSNGATSIENIIFFDSVDPASLLSFDQLLSRGEREYCMLLGAYPV-PTRSKKDDLAFIMYTSGTTGNPKGVMISHQNI---VAVTAGQAFNIVLGPDDRYIGYLPLAHILEVCAEMVVFTK-AQTLFDRAPKIMKGEHGDCWVLQPTLMACVPAVMDRIFKAVIDERIGKLLGGKVRQILSGGAPLSPETQRFMNICFCCPVVQGYGLTETCGGGTIADIHD-GPPLTCCEILLQEWAEAGYSPKNDPPQGEILIDEKTKEEFVKV-FATGDIGEFRED----GS------KIIDRKKDLLKLAGEYISLGKVETNLLTNPNVDNVCVYGDSNKSFLVALVVPNQKNLTQLASKAGASNDNFEKKVVEALQKELAQYGASKLQRVEIPQK.............. 687
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zhang B, Jaroszewski L, Rychlewski L, Godzik A. Similarities and differences between nonhomologous proteins with similar folds: evaluation of threading strategies. Fold Des. 1997;2(5):307-17.