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Query: [M] COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKSVRYLIGLFAFIACYYLLPISTRLLWQPDETRYAEISREMLASGDWIVPHLLGLRYFEKPIAGYWINSIGQWLFGANNFGVRAGVIFATLLTAALVTWFTLRLWRDKRLALLATVIYLSLFIVYAIGTYAVLDPFIAFWLVAGMCSFWLAMQAQTWKGKSAGFLLLGITCGMGVMTKGFLALAVPVLSVLPWVATQKRWKDLFIYGWLAVISCVLTVLPWGLAIAQREPNFWHYFFWVEHIQRFALDDAQHRAPFWYYVPVIIAGSLPWLGLLPGALYTGWKNRKHSATVYLLSWTIMPLLFFSVAKGKLPTYILSCFASLAMLMAHYALLAAKNNPLALRINGWINIAFGVTGIIATFVVSPWGPMNTPVWQTFESYKVFCAWSIFSLWAFFGWYTLTNVEKTWPFAALCPLGLALLVGFSIPDRVMEGKHPQFFVEMTQESLQPSRYILTDSVGVAAGLAWSLQRDDIIMYRQTGELKYGLNYPDAKGRFVSGDEFANWLNQHRQEGIITLVLSVDRDEDINSLAIPPADAIDRQERLVLIQYRPKLast
1 -127.000[M] COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family  ali  100  1MKSVRYLIGLFAFIACYYLLPISTRLLWQPDETRYAEISREMLASGDWIVPHLLGLRYFEKPIAGYWINSIGQWLFGANNFGVRAGVIFATLLTAALVTWFTLRLWRDKRLALLATVIYLSLFIVYAIGTYAVLDPFIAFWLVAGMCSFWLAMQAQTWKGKSAGFLLLGITCGMGVMTKGFLALAVPVLSVLPWVATQKRWKDLFIYGWLAVISCVLTVLPWGLAIAQREPNFWHYFFWVEHIQRFALDDAQHRAPFWYYVPVIIAGSLPWLGLLPGALYTGWKNRKHSATVYLLSWTIMPLLFFSVAKGKLPTYILSCFASLAMLMAHYALLAAKNNPLALRINGWINIAFGVTGIIATFVVSPWGPMNTPVWQTFESYKVFCAWSIFSLWAFFGWYTLTNVEKTWPFAALCPLGLALLVGFSIPDRVMEGKHPQFFVEMTQESLQPSRYILTDSVGVAAGLAWSLQRDDIIMYRQTGELKYGLNYPDAKGRFVSGDEFANWLNQHRQEGIITLVLSVDRDEDINSLAIPPADAIDRQERLVLIQYRPK 550
2 -42.600[O] COG4745 Predicted membrane-bound mannosyltransferase  ali follow..  9  1MRRSRDVVAVTAAALLARLWALGWRVAH--DEARVADWTLQYMDLGAWQYRPII------HGPFLPHVNGVVFDVFGATDFTMRLVVAVVGGLLPLTAWLYRTRL--SDVEVGALAVLLAANPVVLYYSRFMRNDLLLAGFMFTAVGLFVRFLDTHRAR----YLYASAVPFALAFTTKENSLLYPLCWLGALALVTDDRMAVAGATDTSRLAVVRLFEQPGRAPAVLEAATIGTYHEFADLWASTSTVAHSYVAFLSHDLSVLVACGTVVSVAAVVGYLANRTETPRPLVSFAFYWGVFSVLGYPAVVIAAAWTAVNALVPLAIPAAVGVGAVVRYGRRGAAAGDTAAVRLAVTVLVVSAAGMGAVAAETTYAHPQSPSNPLV---------------------------------------QYAQPGGTMQPTIDDIQRAATATSGLDVLYYGDSNDTADFPWYLSQ--VGANATTVQTAAEVPDTPPPVVISVVSEEDDFAALLAA......................................... 535
3 -36.700[O] COG4346 Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  13  114...........SFVEYYSYSNFPGVFYRIPVENYKNFTEELREIGNITIIPNIHKYLNTEHPFLGKDIIALGM-LIEDKPFYWRIPGIIEHALIVIIVTLVAYKITKSYLASSIAATFAALDPLLFATGIVAMLDIHVAFFIALFMLFLA-----------LDRIRLSGIALGLAAATKLSGAFAFPILWFKILKEKDLKEYLISGLVLPMVSFLIPEITIIKAIGFIPWLEEFIASFSWHLSFKGEHPSEAPLKPFPFHFDPDVYAV-P-FVFAVPYVSLRRKGLSEIFWMFWSIIAFFALQYILGGKTQFIFYATPLIPPGAVALGVISYEIIKWEYFERSLRIYLNYLRSIAKPLKKVI............................................................................................................................................................................................ 475
4 -24.700[O] KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase  ali follow..  15  68......PVIFTALALFTRMYKIGINNHVVWDEAHFGKFGSYYLRHEFYHDVH---------PPLGKMLVGLSGYLAGLDYVKMRLFNASFSALCVPLAYFTAKAIGFSLPTVWLMTVLVLFENSYSTLGRFILLDSMLLFFTVASFFSFVMFHNQRSKPFSRKWLLITGISLGCTISVKGLFIITMVGIYTVIDLWKSMSWKTYINHWLARIFGLIIVPFCIFLLC.................................................................................................................................................................................................................................................................................................................................... 303
5 -23.900[S] COG5305 Predicted membrane protein  ali follow..  12  1.........MFSLGNSFLPVPLDQA--IAPDILLQPLQPNPASGIGDVIHNLITEDNH---PPLYFVLVHLWMKLFPVSLLAARSFPALLGAVSIPLTYILGRLAFRSSLVGQLAAGMMAVSPYAVYLGQEVRHYTLAMIWVIASLSCLVIATRHIQNRTLFWLIILWVGINALGIATHYFFTLTLCAEALVLIFLAWQQSTQAKTLVYAVAAGTAVAGLVWLPSILENRYR-IFQAFAAWVTMIMLLPIESSQLAVVIASGLVMLIFAIWAT-LVRGFKFQLQQPQTSLATQVFIGVVAIALFFILT-TRGARYNFVYFPAVIILVGASLAVYWQTSKKAVMIIWLMGFVSAVTVI................................................................................................................................................................................................. 386
6 -23.900[O] COG1928 Dolichyl-phosphate-mannose--protein O-mannosyl transferase  ali follow..  11  61......PIIFTVLGMFTRMYKIGRNNHVVWDEAHFGKFGSYYLRHEFYHDVH---------PPLGKMLVGLSGYLAGIDYVKMRLFQAMFSSLCVPLAYFTGRAIGFSRLSVWLFTILVIFENSYATLGKFILLDSMLLFFTVSSYFCLAKFHTMRKSPFSALWLCLTGLNLGCAISVKGLFIISVVGIYTISELLSDRSVSWKVYVNHWLARIFGLIIIPVCV--------FLLCFKIHFDLLSNSGPGDSTMPSLF.................................................................................................................................................................................................................................................................................................... 319
7 -20.300[O] KOG2292 Oligosaccharyltransferase, STT3 subunit  ali follow..  12  15YSSLITFAILLIAWLAGFSSRLFESIIHEFDPWFNYRATAYMVQNGDERAWYPLGRIVGGTVYPGLMITSGGIHWLLHVRDICVFLAPIFSGLTSISTYLLTKELW-SAGAGLFAASFIAIVPGYISRSVAGSYDGIAIFALQFTYFLWVRSVK----TGSVFWSAAAALSYFYMVSAGGVFIINLIPLHVFVLLIMGRYSPRLLTSYSTFYILGLLFSM--VLLMAVATLRHLQSVLSRNEFRKIIASVSEHQPTTW---FSFFFDLHILVCAFPVGVWYCIKQINDE-RVFVVLYAISA-VYFAGVMVRLMLTLT---PVVCMLAGVAFSGLLD...................................................................................................................................................................................................................... 428
8 -20.000[MU] KOG2515 Mannosyltransferase  ali follow..  12  16........WTFSILAVLRLTSASFRVIDDCDEVYNYWEPLHYLLYGEYSEYAIRSWFY----IALHAVPGFLARGLGLSRYFIRGVLACFSAFCETNLILAVARNF-NRAVALHLTSVLFVNSGMWSASTSFLPSSFAMNMVTLALSAQ---LSPPSTKRTVKVVSFITIGAVIGWPFSAALSIPFILLELVDLKGRFRHLFCRWFKAIFVALLITGICI------------TVDSLFYHRNIVKYRGPDIYGTEPWWYYFAVLWFAMACGPLVLLAAFTNWINLDSFLDLSSVISPFYIWLFIFIIQPHKEERFMYPIYPVLCLAAAIGLDMSLKLMIQILSSINETVRSKFPVRFVVLCVYAII........................................................................................................................................................................................ 385
9 -19.300[R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation  ali follow..  11  20WKIPLKVLILICIAVASVSSRLYESIIHEFDPWFNFRASKILVEQG-----FYNFLNWFDEPPGLMVTSGIIFKVL---RDVCVLLAPAFSGITAIATYYLARELK-SDACGLLAAAFMGIAPGYTSRSVAGSYDAIAITLLMSTFALWIKAVK----SGSSFWGACTGLLYFYMVTAWG--GYVFITNMIPLHVFVSKLYIAYTTYYVIGTLASMQVPFVGFQPVSTSEHMSALGVFGLLQLIPIIASVSEHQPPTW---SSLFFDLQFLIWLLPVGVYLCFKELRNE-HVFIIIYSVLGT-YFCGVMVRLVLTLT---PCVCIAAAVAISTLLD...................................................................................................................................................................................................................... 433
10 -19.100[S] COG5617 Predicted integral membrane protein  ali follow..  11  1MKRKLYYLTLATISVIEYLYLAPSPPALQINGNGHLFKVHKLMTSGPWIEDWYAGYPFLR-PPLSYLTAGVLGKVLGSDTKGYAATLMLTSFLGALALHHYLKST---GREPCISPLIFLLFPWHLSYIEGNFPRANAIHLAPLFLLSLYWLREKRERY-----LIASALGISIVALTHYSILPLLIITGILILWDDLRTMTALGNGIKVLGAVIGLTSF------------WYVPFLFDKKWVEFWNISENKALFKSFSLNPTLLKSPFGILLILLLLIFAIFAIKNLVDRKKVILAGLYLYLSLGFYSPTTWLYSFPPPDLEALIIPLLIGESLKRVQRKSMVALVIIPFTVLAFMNVPKI........................................................................................................................................................................................... 359
11 -18.800[MU] KOG2516 Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family)  ali follow..  8  1MRWSVLDTVLLTVISFHLIQA----PFTKVEESFNIQAIHDILTYSVFDISQYD---HLKFPPTSIDVQLVVRGIVGLTNLKNCLQDMFDEITEKKKEENEDKDIYIYDSAGTWFLLFLIGSFHLMFYSTRTLPNFVMTLPLTNVALGWVL---------LGRYNAAIFLSALVAIVFRLEVSALSAGIALFSVIFKKISLFDAIKFGIFGLGLGSAISI-FWQEWCLPEVDGFLFNVVAGYASKWGV------EPVTAYFTHYLRMMF--MPPTVLLLNYFGYKLAPAKLKIVSLASLFHIIVLSFQPHKEWRFIIYAVPSIMLLGATGAAHLWENMKVKKITNVLCLAILPLSIMTSFFI............................................................................................................................................................................................ 379
12 -18.800[MO] KOG1771 GPI-alpha-mannosyltransferase III (GPI10/PIG-B) involved in glycosylphosphatidylinositol anchor biosynthesis  ali follow..  9  1MRIWFWLAILVFRWWNALW----VKTFFQPDE-QSLEVAHHFIFRYGFLTWEWTSAIRSALHPLIFAALYRVLQVLKLDSNAPKLLQGTFAAILDYGTYKFALVRY-GSKTANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSKKAYSSLLGFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSVSLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGL------NAWHYYLSQLPLICGGFLPFVLLTMDLQ-----------TAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWKRAARFFFLIGLGHALVITFLCRF............................................................................................................................................................................................. 376
13 -18.000[G] KOG4123 Putative alpha 1,2 mannosyltransferase  ali follow..  11  12PGDRHLSTYFCFAAVRLLLVFVPQLGYVHPDE-QSVEVMTGDHRTWEFVLPFA----LLRIPWSFYEFVAECLKAWWQLEVFPRLIYTLISFSNDYCLFRICRLYGLRFEIRL---LAMGSSWILLVFGTRTFSNSLEMAMCSWLLCLVIWKLKNSLPAHNLQHLMAMSTICVAGVFNRPTFLLFGAPMVFFWLLRGMGTRSITFRDFNLRIALFCLCALPALVLFIFCDSLYYQHLFIKANLDSAQTASHGVHPCYVHLMVNMPMLFNVLALASLGAFAQLLLRRFQSIVSLMSGAIFVPLFFLSLINHQEPRFLLPVTFPLILLHAPKLITGFSAKYP.................................................................................................................................................................................................................. 431
14 -16.600[S] COG5650 Predicted integral membrane protein  ali follow..  12  50.......VLITTSLVFLAMGFLTKANCIQGSRGTYNDIVPLYGGRG--GFPYAFSTRYMEYPVLGGIFQWICGIITRF-TLPESGLYFIVTALALAFFWVLVIRMMVELTGNRVWDTVLVAASPLVAVHAFTNWDTPAIAAVIGAMLAV-----------KRGNPLVAGVLIGAGTAFKLWPLYLLG--AYLVLAVKNKNLKPFITMAAAAAVTWLVVNVPVMIA----YPKAWNEFL------RLNRERGAEWTTIYQVIDRNLPINL--LFGASCVAILILGLKVQRTPRVAELAFLIVAAFLLFNKVWSPQYSLWLVPLAVLAFPQW............................................................................................................................................................................................................................ 395
15 -13.200[S] COG4485 Predicted membrane protein  ali follow..  10  5LKTYRTYFISFIIPVVIMIYWNSDNSPLLGDGFHFDVALRNILHGNSNLFYTFTGLNFYA---SSYYLGSPLVYFFDLTNMAIYLTTLLKFGLIGLSTFFSLNKLFQSIPLKLALSTSYAMSFTVSQLEIKTWLDVFI--LIPLIITGLHLLITEKKL-------LLYFTSLSILFIQNYYFGYMT-VLFLIFWYLCQSSVLDFIVISFLAGMASLIMTLPTLFDLQTHGEKSWYLDLFAKQFIGSFDTTKYGAIPMIFVGLFPFI------LTILFFTLKSIKFHVKLIYVIFFAFLIASFYIMHTPNMFLHRYAWIFSTLLIYTAAEVLKRLKELKVWN---------FLVSLFLVVAGFLATIYLKSHYSFLTDLNILLTLEFLVVYSLLLLAVIKKFISVNLFAILISLFILVEMSLNASSQMDGIAKEWGFASRSAYSRDIPAMESFSTYIGFNYNGISQFSSVRNRSSSSTLDKLGFKSSGTNLNLRYANNSILAD------------SLFGIQYNISDSPIDKYGFKDIYQKDNLTLYENQ.. 584
16 -12.200[S] COG4713 Predicted membrane protein  ali follow..  8  1MNKRVEYIFMAFALFFGVLFAVINAPFQDPDEPIHFYRAYQI-STGQMFEQKNNSG-----SDIVYIPQSIGINLFRAS-YFGRIANLICWTIIVFFSVKLIPF-------KKNLMAFLALTPMNLYQAASLSADAMTNSMAFLSIALVLRYAFGEEEAKTKRQIVTMIIAFTLLAFSKRIYFVMC----ILFFIIPIKKFNSKKDYIGTFVIMLGACLMSLVTVSVISKILAIQMEFVLSHPITYIHILLRTFHFKMSFYAISFIGVFGWGVALVLIALFEHTLIEKNKDRIIMFIVFIINVGLIMSALYVSRYFIPIIPLLGCFIGVKANKSRNVYSKVVLAISTFTILTYSVLQLLLRFYGI......................................................................................................................................................................................... 453
17 -11.500[S] COG4906 Predicted membrane protein  ali follow..  8  182.NRTFAIWSIAISLMWSTVFGVSWNYIWGYDINGEYYYANLVLARGIW-SISTYDQ--YNTIASVNILGPVYSLILNMWVPIFKIIYPLVFSLVPVILLKAYERLLGNKIWAELSVLFFMFFFQFFVSNMALARMMIVEVYLALLAYATI---------RKINPLFLILFLASL-AVSHYGTAYLTMFALLTLPLIRVLENEQRISNKL--IAVFWVVTLLWYAYVGGGFQFNNLVIIGYQTLLMLKDLFNPQYSQ-IAKLINLFAQGLISIGVLTVLNRLIRGRKVKHLEFYALSFAFFAYDIARMNVNRLYHLTQFFIAPYLLIGFDSVKRIMNNLSKNRHTLPLKNSVEIAGVFLVVYFI........................................................................................................................................................................................... 551
18 -11.500[S] COG3463 Predicted membrane protein  ali follow..  10  1MKSLIDKKLLVIIFIAYTFIIF-NFSYKSLDLGIFSQSLYSTL-NGKFMYNTVEAQLYSAPNHFILLLLLPVYAIMP-SPVVLLLIQAIFLALSATLALLIACEELNHR----EAILVASLYIFNSSLLGIALFEFHPVSLAVPLFFIAYMLLKRGK-------MKLFYLTSVLILLTKEDSFLGV--VSLSLWKILMDGLNPESFRKNRGLILLSIASMMYGIIVIKVVIPHLGMGY--IYESLYSEFELTRRKLLYFIVFNASFGFLTFL----------------SSKGLVSVALPWLESMLSSRDTQT-HYPYMLLPLSYLVAIEGFKKSKKVAVSLIVAGILTSMATIPITFK................................................................................................................................................................................................ 341
19 -11.400[G] KOG3893 Mannosyltransferase  ali follow..  10  429LYAPTDAFLLLLLGLLMRLVLLNYGIWHDR-ALKFTDIDYFVFSDASKYVSI-GMSPYYRYTPMLAILLLPTQYGF---PSWGKYLFSISDLIAGWLMIKLLSRRISYKRSLIYSSFWILNPFVAIISTR-GNCEAILGILSIALLYLIEKK------------VWLASLILGFSVHFK-PFMYGIAFLVYFSKPKKGSTFMEKFNQLKIVVGSLFMFTICNLLMYYLYGSPFLEHTYLYH----FGRTDHRHNFSLHHLNLYYESSASSLFAFLPQLSLCMLIPLVFGKKNLPGTLFAQTFAFVTFNKVCTSQYFMWYLVFLPLVL............................................................................................................................................................................................................................... 751
20 -10.900[S] COG5542 Predicted integral membrane protein  ali follow..  8  87..........................WIRWDAIYFVDMAV-------------NGSLFEQESPKIISFLAFRSKDVVLLGIVSCFASIFFHAIACYALYLLTKSIFSNQKMTAYTVIFYCFSPSGIYMS-VGYTESLFAAFSFLGLLLF-----------IKKQQYPAAFLWSLATLIRS--GIFWCIFFGMPAIGTLKISLERLQLTFMQVSQLVGYGTKCLIILVP---PAVQEKYWNVGFLRYWTLNN--------FLFALLSIIPILFALFYSISGSTLHSFRSIKSHLVLSALYLYIGCFHMHTQVLNRMSS-ALPLLYWSMAHATLYAKSRNLKAFGHCILFVWIVYTVIQAGLYG............................................................................................................................................................................................ 420
21 -10.300[R] KOG2647 Predicted Dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  10  75..........................SVVWDSVYFLRITECEYEQTYAFLPLL--------PFFISLLSRTVFAPLVPL-LSGFTVSNLAFIFAAIYLFRVSVIILKDTEASFRASIIFCFNPASIFYS-SIYSESLYALFSIGGVYHL-----------LSGTSNVGVLWFALSGCARS--GILNAGYICFQTMHRAYEALYQKRRAYLAMQVFIAGFLRCICICL-------FVAFQAYGYYNICHGHTRDEVR-------------PWCKGRIPLLYNFIQK------ILVSDRGVGFLKYFQFK--QLPNFLL-ASPILSLAVCSIM........................................................................................................................................................................................................................... 339
22 -10.100[G] KOG2762 Mannosyltransferase  ali follow..  14  49........LLILFESMLCKIIIKKVAYTEIDYKAYMEQIEMIQLDGMLDYSQVSG----GTGPLVYLIYKMMYWL-MDHVERGQVFFRYLYLLTLALQMACYYLL---HLPPWCVVLACLSKRLHSIYVLRLFNDCFTTLFMVVTVLGAIVSRCHQRPKLKKSLALVISATYSMAVSIKMNALLYFPAMMISLFILNDANVILTLLDLVAMIAWQVAVAVPFLR---SFPQQYLHCAF---NFGRK-----------FMYQWSINWQMMDEEAFN-----------DKRFHLALLISHLIALTTLFVTRAKTIPFVLIASNFIGVLFSRSL........................................................................................................................................................................................................................... 370
23 -9.760[P] KOG4505 Na+/H+ antiporter  ali follow..  9  6VEISKPHLAYAIIGGFTSLFMLCSLII---KEKLFLGEATMATATGLIFGPYFVPTSWGNTDYITEELVLLVVEVFGAE--MFVM-LLPVMIFGWLVSTGFMYALIPR--LSFLESLAIAACI--------TATDPVLASSIVGKGKFLRNMLLAESGCNDGMAIPFLYLAIYLIILYECTFGCVLGAIIIARKMIKFSERRGLMDRESFLVFYFVLALFCGGIGTIIGVDDLLVSFCAGAAFSWDSWFSKKTEESHVSNVIDLLLNLS----------------------FFVYVGAIMPWPQFHMPHMDLSVWRLVVLAICILIARRIPAVLLFKSFVPDIINWREALFAGHFGPIGVGALYTCLVARAELEVHSTVPEPNDAIENPEIPNWYC-------IQVMWPVVCFLVLSSIIVHGSSIAFFMLGKRINTLALSFTRTRDSHF.................................................................................................... 455
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;