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Query: [K] COG1846 Transcriptional regulators, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MENNNPLQSENHASLRLGRLILQLRRLESTPRTFGRAGALTPSEIHTIDAIGTDEGLLMKELAERLGVTKGAVSQLVDRLEAKALVRRTAHPKVSRGIQVVLTDKGREAYRAHADMHAAFYEELQQSFTKEEIAIFEQCVSKLRDILSELast
1 -58.700[K] COG1846 Transcriptional regulators  ali  100  1MENNNPLQSENHASLRLGRLILQLRRLESTPRTFGRAGALTPSEIHTIDAIGTDEGLLMKELAERLGVTKGAVSQLVDRLEAKALVRRTAHPKVSRGIQVVLTDKGREAYRAHADMHAAFYEELQQSFTKEEIAIFEQCVSKLRDILSE 149
2 -37.000[K] COG3355 Predicted transcriptional regulator  ali follow..  15  23.....................................YGLSKSDVEVLHILLQNGKMTTDDLSQKLNVTKASISKALNNLLDKGLIQREKAPAEKEERKGRPNYIYWVEKERLYRKLEADLEKLAGTVKEALQKHTALEI......... 125
3 -34.800[K] COG5631 Predicted transcription regulator, contains HTH domain (MarR family)  ali follow..  12  44..AEGGSPAMSEVEYGLILASHAFSRWMVRCMAAAGLPGLSPIEILILHSIRHRDRKKLADICLALDIETHIATYAIRKLEKAGLLTTGK---AAKEKTVKITAKGAEACAHYAQIRERLLVDSTANAREETLSELAALLRFMSGAFNQ 191
4 -24.900[KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon  ali follow..  14  1.......................................MKMKTLFLLIKLAKMGTVTMRELSRELDVSPQTVLRWLEELKEQGYIHKRE---SRKGTLVELTEKGINLLEKLYEEISTALYSGFIVGEVSGIGEGAYYVRQYAPLIRE 114
5 -21.800[S] COG2469 Uncharacterized conserved protein  ali follow..  19  182........................EYIQNFIEKSKPKEKLSEVEEQILTMV--YTGVDSVSVESILGVTTEELNKMYDRLVNLGLARVVKIRKE-----IELTPRGVALVSEIMKKAAR.............................. 269
6 -19.400[K] COG1510 Predicted transcriptional regulators  ali follow..  12  8..................IIEHAEEHLIEKIAENMHTFGMPSTVGRVLGII-NRKPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISLFAANWTKVVSKNKVLYKKEKVNQLLNELKEWLHYYDW 158
7 -18.400[S] COG3373 Uncharacterized protein conserved in archaea  ali follow..  9  16........................................SELRRKVLFYLLSPYRSYLSEISRAVKSDPSNVKGCLESLIGLGLVIVE--QSKNGFKYFKINPEIVEEVRNMKNMFSDKKVYTVE....................... 111
8 -16.900[K] COG2345 Predicted transcriptional regulator  ali follow..  17  15........................................GDTRRKILLILLERAPVIASDIAEQLQLSTVGVRRHLDNLVEENLAEAANPRQNRPAKTYRLTDKGRSIFHEYDSLAAAALATLREVGGDDAVRQFAR........... 121
9 -16.100[S] COG2512 Uncharacterized membrane-associated protein/domain  ali follow..  27  246.......................................LSPELCEVLDIIRGHKGITQKDLRSKLDYSEVKVSLMLSELEKRGLIRKLR-----RENILVLVDEEH.......................................... 311
10 -16.100[K] COG1321 Mn-dependent transcriptional regulator  ali follow..  20  5.......................................HTDRIEEYLETIKNQGPAKTKQIAEELNVSSPSVTEMIKKLHSMGFVEYKPYQG------VELTEKGAEEAVRIKRKHQVLETFLADVLDFDEHAVSDSVLERLYDFLGN 124
11 -16.100[K] COG4738 Predicted transcriptional regulator  ali follow..  13  17......................KMGEVEYEMVELLRRLNINRPVALTLACLSKGDEISSQRIEMVSGLRQPEVSIAMRYLRENEWVDMREEKKNHG--------KGRPVKLYKLTVQMETIIDTIEENVIAESKTILQNIERLKS.... 131
12 -15.900[K] COG5625 Predicted transcription regulator containing HTH domain  ali follow..  15  4........................EEMLKKLEDLLKAIGLKKNEIRIYRLLVEKRRMRIREIQRELGISERSVRTHVLNLYRRGLLKRELVQSGWLGYIYTPVSP-LEILQKIKEHLMKSIEELERDLKNQTRS............... 113
13 -15.300[K] COG3432 Predicted transcriptional regulator  ali follow..  9  43..............................................ILRNC--EPKCGITRVIYGAGINYVVAQKYLDQLVKVGALNIK---TENDRKIYEITEKGKLLRTHIEEF-------------IKIRENLYSAKEKVSELLRT 127
14 -15.000[K] COG1695 Predicted transcriptional regulators  ali follow..  10  1.......................................MDRYAIKALVLLSKKP---SKEISTGVQVSHGTLMPMIRKLLQERYIDFETRGREK---VYHLTERGSRFVESLGKIEEDVKQNLISRTKNDTSEAIKSAIQILLPAIIA 122
15 -14.800[K] COG1497 Predicted transcriptional regulator  ali follow..  23  10.........................................LTRFQILSEIAMRQPVRQKDIADKLGVTVQAVSENIKSLIAEGLVESG-----SGRSHYKITRRGAEKIKEAAMDLRRYADEVLESMSFYRSV............... 98
16 -14.800[S] COG4519 Uncharacterized protein conserved in bacteria  ali follow..  10  11............................................LYLALLVESLERPNVPKLIEKTGWPRRTIQDVIKAMPGIGIELNFVQDGRRHNDYYQLSDWGPFDSQWVTERKKDIAASL......................... 91
17 -14.600[K] COG4190 Predicted transcriptional regulator  ali follow..  22  67.......................................LTPRVLELIEAIRQEEPASINETARVVDRDVKNVHEELSRLAHLGIIFFEEDGQRKR..................................................... 123
18 -14.100[K] COG4742 Predicted transcriptional regulator  ali follow..  18  12........................................SQKRRDLLLLL-GEEPRTMEDIKVLLDVSPTAILPQIKRLTDSNLVIQKNGS-------YELTDMGEQVFKKARALVDVL............................. 83
19 -13.900[S] COG3398 Uncharacterized protein conserved in archaea  ali follow..  18  185........................................NATNQRIISEIQNGKCNTNLALAREIGVSRATISWYVKNLKETGLIDETR---SGRSIIYSINPSYEPLIEKY.................................... 254
20 -13.600[K] COG1522 Transcriptional regulators  ali follow..  16  1..................................MSKVELDKIDRKILEVLQSNGRLTNLEVAERVNLSPSPCLRRIRRLEESGVIRQYAALLDPGKIGLGLS------------INVRLEKQGGAPKGKAPSDIFRAAVATWPEVVT. 104
21 -13.500[S] COG4344 Uncharacterized protein conserved in archaea  ali follow..  8  2............................SEYEKEIDELINDYDMLRVLKHFTIAHVDYAKNITRYTEIPQMRVREYLKRLKDLGLLDYYTNEVHKHHTYYQINKKAEAVLKEI.................................... 100
22 -13.400[K] COG3682 Predicted transcriptional regulator  ali follow..  16  3.......................................ITAAEAHVMEALWRRSPLSADELVAEVGAAQSTVKTLINRLLKKKAIKSER--AEGKHGYRPLVDRSAYVQAESQGLLDRLFDGQLRPLKPDEVAKLKKLIDEMGE.... 120
23 -12.500[K] COG1777 Predicted transcriptional regulators  ali follow..  19  14........................................NSTRREIIRMLTQFERSYALELSRSIGLSQQAILKQLEMLERANLVTSIGFVPSSV..................................................... 69
24 -12.200[S] COG3388 Uncharacterized protein conserved in archaea  ali follow..  14  16.......................................TLKRHISVINVLLREQPIGIIKLSQETGIPEHKIRYSLRILEQENIISPSRE--------AILTPDFIEHKEQIIADAEKVLEEA......................... 93
25 -12.100[K] COG1733 Predicted transcriptional regulators  ali follow..  17  13..................................SMAAEVLCTRWTMVLMRELVAGSTRNDLRRGVKMSPTLLSQRLKELELAGIVERKEVPGEKGIFDYRLTEAGRDLRPVVEAMGF............................... 98
26 -11.800[K] COG1378 Predicted transcriptional regulators  ali follow..  9  23...........................MDEIIEVLKRLGFRDYEARVYATLATRGEATASEIHRVSGVPRNKVYEVLRSLEDRGMIETIKSSP-----AVFRAIDPESVLEEYKEQLVSAVDTAIRSIRERGLAGIKNRAKAMLQRSEE 152
27 -11.400[K] COG1414 Transcriptional regulator  ali follow..  11  21............................................LDILELLASVDGLTQAEIAKHLDRSPNEFYRMLDRLVKRGYVTK--LDGDRYSLTLKLFGLAQLHAPVR-------------RLASFATPFMRELADRSKQANQ. 110
28 -10.900[K] COG1802 Transcriptional regulators  ali follow..  24  30..................................................FTPGERLIERELCETLGVSRTSIREALRRLEAEKLVSIVP---HKGPIVAIISQEAAELFALRGLLEGFAAREFAQRATDVAIVHFAQAIQALRMAGMT 126
29 -10.500[S] COG4754 Uncharacterized conserved protein  ali follow..  14  17..............................................LLYVMNNDGKTDLYQLEKEMEVDIDDLMPIVYTASRLGFVSAESGD-------IIVTEEGKEYIRASIKRRKEIIREALR-----NIEPFRTALDLRNFD... 106
30 -10.500[K] COG0640 Predicted transcriptional regulators  ali follow..  18  1..........................................................MNEITMQTQADQPKVSSNLAILSEARLVDSIQ--------------MGREKI----------------RIAPEKFEDMVDWLDSILH.... 58
31 -10.300[K] COG1675 Transcription initiation factor IIE, alpha subunit  ali follow..  11  27..............................................ILFSLGIEGEFTDDQLSLELGIEINEIRKALFALYEIGLADYVRRRDDETGWMEYY----DKALDVLKRELEKTAKKLREKIEAET................. 113
32 -10.300[J] KOG2784 Phenylalanyl-tRNA synthetase, beta subunit  ali follow..  18  43..............EHLERWFQHLSSFEMTAETDVRS--TENLPQQILDFLQESNEFNSIQLAQQWNLDHQKVIGAIKSLLAEGVLT-----KDVTEKRLELTNEGVQFANE..................................... 135
33 -10.200[K] COG4189 Predicted transcriptional regulator  ali follow..  21  22........................................SLIRVQILKLLHEANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRKARKGSQKI................................................. 81
34 -10.200[K] COG2186 Transcriptional regulators  ali follow..  21  38.........................................................AERELAQKLGVSRPSLREALIALEIDNTVEIRMEALQTTHHTKSLGDSPSELMQARAALEGATIVLAANRMTDETIAALRQILNTMQKEIEA 137
35 -10.000[K] COG3327 Phenylacetic acid-responsive transcriptional repressor  ali follow..  17  42.........................................................SLAALLEGLGFGERFVRTALFRLNKEGWLDVSR---IGRRSFYSLSDKGLRLTRRAESKIYRAEQPAWDG-DKSTLADVKKQLIWQ...... 133
36 -9.790[K] COG0583 Transcriptional regulator  ali follow..  23  5.......................................LDWDKLRIFHAAAEAGSFTHA--AQTLHLSQSAISRQVSALEQD-LFHRHARG-------LILTEQGETLYRTAHDVLMKLEN........................... 81
37 -9.720[S] COG4861 Uncharacterized protein conserved in bacteria  ali follow..  17  143.......................................FTPKRAQVVCVLLDAPQLPLRAIAASAGVSVGMAKETMDTLRTTGFFEHLGS.......................................................... 197
38 -9.710[K] KOG2593 Transcription initiation factor IIE, alpha subunit  ali follow..  6  1............MVKLVAKTFYDNYTPKNNNQKKSAKNGSGGIAVLVLDALTRRQWVREEDLAKELKLNTKQLRTILRYFEEQQFIMRVHRKEKSSATTNGRGEDKVKVHMYS----------------SQIYDVIRYKLHRMKKEFKD 127
39 -9.670[K] COG1725 Predicted transcriptional regulators  ali follow..  15  36.........................................................SVREMGVKLAVNPNTVSRAYQELERAGYIYA------KRGMGSFVTSDKALFDQLKKELADAITERFLEGLDDQTAIELLI........... 115
40 -9.490[KG] COG1349 Transcriptional regulators of sugar metabolism  ali follow..  17  7...........................................QAAILEHLQKQGKCSVEELAQYFDTTGTTIRKDLVILENAGTVIR............................................................. 51
41 -9.360[K] KOG3233 RNA polymerase III, subunit C34  ali follow..  10  87......................................GSDNQEKLVYQIIAGNKGIWSRDIRYKSNLPLTEINKILKNLESKKLIKKSVAASKKKVYMLYNLQPDRSVTGGAWYSDQDFESEFVEVLNQQCFKFLQS........... 190
42 -9.190[K] COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain  ali follow..  16  13...............................................VAQMYFSEHKRQAEIAQHLNLSQATVSRMLKRAEAEGIVRTSIIPPPGTYSDLELRERFDLPEAIVVDCSEDRDGAIMARIGEAAAHFLEVTLSQ....... 109
43 -9.140[K] COG1654 Biotin operon repressor  ali follow..  22  9.............................................TLISLLADGEFHSGEQLGERLGMSRAAINKHIQTLRDWGV................................................................ 48
44 -9.070[K] COG5111 DNA-directed RNA polymerase III, subunit C34  ali follow..  16  82......................................TMEGDEQIVYSFIKNNEGIWRKTLTLRTNLHVSVVDRCLKSLESKNLVKSIKSNPTRKIYMLYDLVPSTELTGGPWFTDQELDVEFIENLKKVIYRYVHS........... 185
FFAS is supported by the NIH grant R01-GM087218-01
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Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Rychlewski L, Godzik A. Improving the quality of twilight-zone alignments. Protein Sci. 2000 Aug;9(8):1487-96.