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Query: [E] COG2066 Glutaminase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRQTNNKESTMKPTADILASIIEEVRPLTSKGIVADYIPALAKVPSDKLGIAVFTNQGEVITAGDAQEGFSIQSISKVLSLTLAMGLYQPDELWSRVGKEPSGQAFNSLIQLEMEQGIPRNPFINAGAIVVCDMLQSRLSAPRQRLLEFVRQLSGEPQIAYDKVVAASEMMHSDRNAAIAYLMRSFGNFHNEVIPVLHNYFHACALKMSCVELAKTFSYLANKGVSVVTGETVITPTQSKQTNALLATCGLYDGAGEFAYRVGMPGKSGVGGGIIAVVPGEMTIAVWSPALDQSGNSLAGTRALELLAQRIGRSIFLast
1 -119.000[E] COG2066 Glutaminase  ali  100  1MRQTNNKESTMKPTADILASIIEEVRPLTSKGIVADYIPALAKVPSDKLGIAVFTNQGEVITAGDAQEGFSIQSISKVLSLTLAMGLYQPDELWSRVGKEPSGQAFNSLIQLEMEQGIPRNPFINAGAIVVCDMLQSRLSAPRQRLLEFVRQLSGEPQIAYDKVVAASEMMHSDRNAAIAYLMRSFGNFHNEVIPVLHNYFHACALKMSCVELAKTFSYLANKGVSVVTGETVITPTQSKQTNALLATCGLYDGAGEFAYRVGMPGKSGVGGGIIAVVPGEMTIAVWSPALDQSGNSLAGTRALELLAQRIGRSIF 316
2 -7.290[V] COG2367 Beta-lactamase class A  ali follow..  11  10................................TVAEQLNAICDVQPFVTRFMVRNLLTGEEIGRGENEETPSGSTRKTSIMMAVLKA------------------------------------ASEGRIDLDQPVTYEKRLAEEVASGMFRYMTPGIVISLRDAIAGMMVLSD--NVCTKMVLERLTL------EEVDGYCKSLGMATSAADQVLLLQTILDAQSSPEAQAKGCSPQLCEWAMQTLK-----NQILRYGIRSRLPFKSGRGKRGIVYRNGSFIITTYTDEVDGTPGYTIALETIGRLAQAC..... 282
3 -6.480[V] COG2602 Beta-lactamase class D  ali follow..  10  73....................................................................................................TPQSTFKVVNAL-----------LQVKAVRDEYDVKRWDGVKREFE----RDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGIDQFWLQSSLTISPLEQETFLEKLAKEEL--------FDKPVMKIVKRMMIQEEGDHYT--------LYGKTGTRGWFVGFIKTEHGSYVFVTNVDDSGTKAK--NITVDILKKYGL... 264
4 -6.440[E] COG4448 L-asparaginase II  ali follow..  15  44..................................................AVVVDGDGGVFSAGDIERGIFPRSACKAMQ-ALPLVESGATDAYGFGNRE-SGEDAHAELAAAMLAKAGRDV-LECGAHWSSDQKTIIHQARTLEKPTALHNNCSGKHSGF--------CACCHTGTDPKGYVGYDHPLQRQIRATMESLTGACSIPTYAVPLKGLAHGFAK--ATGRGLEAERAKASRRLIEACMAEPFYVAGTGRACTKLKIFAKTGAEGVFIAALPNQIAMAV------EDGTTRAAEAMVTALLARYFD... 320
5 -6.010[M] COG4953 Membrane carboxypeptidase/penicillin-binding protein PbpC  ali follow..  12  256..................................APLFSRMMLGKSKSDKIT-TTLDAGLQRRLEELAQNWKGRLPPRSSLAMIVVDHTDMRVRGWVGNDDSRFGHVDMVNSIRSPGSVLKPFVDEGLIHPASLLQDVPRRTGDYRPGNFDSGFHGP-ISMSEALVRS------LNLPAVQVLEAYGPLYLPNGAAPNLSLILGGAGAKLEDMAAAYTAFARHGKDPLLERPLMSSGAAWIIRRIMADEAQPLPDSALPRVAPLAWKTGTSYGAIGVNARYV-IGIWTGRPDGTPVGQFGFASAVPLLNQV..... 560
6 -5.910[V] COG1680 Beta-lactamase class C and other penicillin binding proteins  ali follow..  12  50.................................................GMALVVIDGNQRSYGQLDSVVRIASLTKLMTSEMLLLDQGTVKLNDPLSKTYNGTPITLVNLATHTSALPREQYSNLAFDLLADALANASGKPYTQLFEEQI-----RPLGMKDTTYTPSPDQCRR--------LMVAERGASPCNNTLAAIGSGGVYSTPGDMMRWMQQYLSSDF--YQRSNQADRMQTLIYQRAQFTKVIGMDVPGKADALGL-QKTGGGGGFMAMIPQKIGAFVVVTRSPLTRFKNMSDGINDLVTE....... 373
7 -5.530[S] COG2014 Uncharacterized conserved protein  ali follow..  9  3..............GMLLSRIKKKAMELAEDLKLVDFS-LVEGIEGRALGVAMTLPEEVQRYTNSIEEPSLLEFIDKADSLNIIERTLGVAAINAVSQYYIDLREAKWIDVTELIQQDEIKRIAIIGNMPPVVRTLKEKYE---------VYVFERNMKLWDRDTYSDTLEYHILPEVDGIIASASCIVNGTLDMILDRAKKAKLIVITGPTGQLLPEFLKGTKVTHLASMKVTNIEKALVKLKLGSFKGFESESIKYVIEV...................................................... 248
8 -4.970[A] KOG1919 RNA pseudouridylate synthases  ali follow..  12  22..........LRRVPPYYYEYITFAKLRWYGKTLLEVFTEFRDRESGYYEKAI--RNGQVKVNNQIGNVDTLIENGYIVSHHAHRHEPPVSDQPVGIVHED-----ESYVVIDKPAGVPVHPTGRYNHNTVLHILMKENKCSLLYPCNRLDRLTSGLMFFSKSPKAAEEMRVHMISKSLKYVARVIGEFPNSGEVICDA-------PLLTVAPTLGLNRIHPDGKEASTVFKRIAFDGHTSLVLCKPLTGRTHQLRVHLQYLGYP................................................... 265
9 -4.960[M] COG0744 Membrane carboxypeptidase (penicillin-binding protein)  ali follow..  14  311.................................................GMRVTTVDANFQTMAEDTVKKWHKTLLSRNQIALVAIDPRTHFVKALVGVDSRASEFNRATQALRQPGSSFKPFVYYAAFATGKFAPDSTVIDAPVRYRDGNNWYSPRNYDFSGAMSIRTALAQSRNIPVIKLGKTIGMIMSPMEPVTSLPL---AIGVTPLEMASAYATFANYGWNTPKPQLVLDPWASAAIIDVMRSVVTNGTGKGAAIDRPSAGKTGTTSSYVGTVPQLTAVWIGRDDNRQLASGATGGGKVAPIWRDF..... 615
10 -4.930[R] COG1411 Uncharacterized protein related to proFAR isomerase (HisA)  ali follow..  10  1.............................................................................MFRVVFVMDIFNRNVVLAKGGVRENYRPVSDSSAVCRTS----APLLRPREVYIADLNALQGKGPLDINAEVIREVSLKADTMLDFGVSCLGDVDRALSIAGTAVLGTETGKLSVIRDAVARCPGRISVSIDVKY-DLIFLDLDRVGTASGFDPEFLHKLAETSIHDVLLAGGVRGME-----DLFTLDRLGIKGALVAIHSGEVPLEVMNLGLEQIKRD................... 244
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zmasek CM, Zhang Q, Ye Y, Godzik A. Surprising complexity of the ancestral apoptosis network. Genome Biol. 2007 Oct 24;8(10):R226 [Epub ahead of print]