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Query: [Q] COG2132 Putative multicopper oxidases, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTGWTRRGLLKTAAVAGATGVGLSAIGRLGGLAATSPEPMVLQTAKIQARLMDIGPTNNVLTYGNAGMPPVLRMKKGEPFAARLVNAIDDPTTIHWHGIRLPNKMDGVPFLVQPYVNTGDHFDYAFTPPDAGTFWYHPHCNTLEQMGHGLTGVIVVENPNDPKFDAEFVLNLRDWRLGDDGQFIDQFRPRDAAKTGTYGTVRTANWLDQPQYDAPAGGLVRLRVAITDVTRIYAFRVDGAEAIVMALDGNPVPERFSPDALLLGPGQRMELAIRMPDREGAVVSLRDVRGTKPKILATVRATGSSLKRDVRDVAPLEVNPVAEVDLSAAQHISLALSATAENVPSDGICGSLGYSFWAINKVPWPGDTSDPTAPLAELKLGKSYVIDMENLTPQSHPMHLHGMGFKVLSSSTRPVQPLISDTYLIQPNEKVQLGFVADNPGDWLLHCHIIEHQKSGMTSYVRVVLast
1 -127.000[Q] COG2132 Putative multicopper oxidases  ali  100  1MTGWTRRGLLKTAAVAGATGVGLSAIGRLGGLAATSPEPMVLQTAKIQARLMDIGPTNNVLTYGNAGMPPVLRMKKGEPFAARLVNAIDDPTTIHWHGIRLPNKMDGVPFLVQPYVNTGDHFDYAFTPPDAGTFWYHPHCNTLEQMGHGLTGVIVVENPNDPKFDAEFVLNLRDWRLGDDGQFIDQFRPRDAAKTGTYGTVRTANWLDQPQYDAPAGGLVRLRVAITDVTRIYAFRVDGAEAIVMALDGNPVPERFSPDALLLGPGQRMELAIRMPDREGAVVSLRDVRGTKPKILATVRATGSSLKRDVRDVAPLEVNPVAEVDLSAAQHISLALSATAENVPSDGICGSLGYSFWAINKVPWPGDTSDPTAPLAELKLGKSYVIDMENLTPQSHPMHLHGMGFKVLSSSTRPVQPLISDTYLIQPNEKVQLGFVADNPGDWLLHCHIIEHQKSGMTSYVRVV 464
2 -83.400[Q] KOG1263 Multicopper oxidases  ali follow..  14  2............KGGVKLLAVCLCVATATVMMVQAEDPYFHHVWNVTYGTASPLGVPQQVILINGQFPGPNINSTSNNNVIVNVFNNLDEPFLITWAGIQHNCWQDGTAG-TMCPIPPGQNFTYHFQPDQIGSYFYYPTTAM--HRAAGGFGGLRVNSRLLIDPEDDYTILINDWYTKSHTQLKKFLDSGRTI---GRPDGILINGKDKPLFTLKPGKTYRVRICNVGLKASLNFRIQNHKMKLVEMEGSHV-LQNDYDSLDVHVGQCFGVIVTADQEPKDYYMIASTRFLPLTTTGLLRYEGGKGPASSQLPAAWNLTASAARPNPQGSYHYGKINITRTIKLVNTQGKVDGKLRYALSGVSHQIKNIKIEPNVLNITHRTFIEVVFENHERSVQSWHLDGYSFFAVAVE-NLLDAVSRHTVQVYPKCWAAILLTFDNCGMWNIRSENAERRYLGQQLYASV. 520
3 -22.300[S] COG4633 Uncharacterized protein conserved in bacteria  ali follow..  13  37TERSQTTQFRRIEQPLWVKGAVTTVGLGLIGLEIWWFLLSK---PKSQKAEARDGIQEVGITVDGGYEPSRILVNAGQRVRLNFLR---RDPSSCLEEIRLPDFH------IAKNLPLNEVTPIEFTSDKPGTYTFNCGMNMFRGVIEVQPTDSTAKATSVTTSQSTHQIQPELSLPTESATKAVKTP-------------------------------------------------EGTQEATITVEKGYKPER------------------------------------------------------------------------------------------------------------------------VIVEVGQPVRLDFQRHNLSKCFDKLLIPDFDL--------------AVNLAPNQTTSVEFTPKYPGEYQFTCGM-----KMYRGVVEVK 300
4 -22.000[P] COG4454 Uncharacterized copper-binding protein  ali follow..  19  60...................................................................................................................................................................................................................................................................................................................................................................................TPAKFEFKKGKTVRFAVKNVGELDHEFILDEQKANLEHKAVMAKAPEMEHAISLAPGESGEIVWKFTNDGMFEFACLKPGHYEAGMRGDLKV. 155
5 -17.000[C] COG3794 Plastocyanin  ali follow..  11  1...MHRRAFLAGGTTLSVGVLAGCIGPSVSKSDYDIGMVSNGFVPQEPVEGEDM---------------ATHQLTAGDTVT------ANTGSRNH----TVTAYGSGLPEEGGGNISPGATYEVTL--TVPGEYYYFPHEGA------GMRGKLVVDD.................................................................................................................................................................................................................................................................................................................. 149
6 -12.400[C] COG3241 Azurin  ali follow..  19  78........................................................................................................................................................................................................................................................................................................................................................................................VSKACKEFTITLKHTGTQPKTSMGHN----VIGKTEDDDARVVAHTKLIGGGEESSLTLDPLADGEYKFACTFPGH--ALMNGKVTLV 182
7 -10.900[C] COG4263 Nitrous oxide reductase  ali follow..  12  218.......NAIDAETMEVAWQVIVDGNLDNTDMDYSGRFAASTCYNSEKAVDLGGMMRNERDWV-FDIPRIEAEIKAKRFVTLGDSKVPVVDGRR----------KDGKDSPVTRYIPVPKN-PHGLNTSPDGKYFIANGKLSPTERLGDLFAGKLADPRDVVVGEPELGLGPLHTTFDGRGNAYTTLFIDSQLVKWNLADAVRAYKGEKVDYIRQK--DVQYQPGHNHATLCETSEADGKWIVVLSKFSKDRFLPTENDQLIDISGEEMKLVHDGP-----------------------TFAEPHDCILARRDQIKTRKIWDRKDPFFAETVKRAEKDGIDLMKDNKVIREGNKVRVYMVSMAPS------GLTEFKVKQGDEVTVTITNLDEIEDVTH----GFVM---------VNHGVCMEISPQQTSSITFVADKPGVHWYYCSWALH--MEMCGRMLV. 633
8 -8.080[P] COG3540 Phosphodiesterase/alkaline phosphatase D  ali follow..  11  6.NTLTRRSFLFSAGAAGLVASSGLATPFYARGYGRPEFAH-----------VQSGDVDTGSGM--------TRVDRPARVSVEYSTTESFSNAVRLADIDATPLTDCAVKCRLHNLLPDQDIFYRFIATDLDEVGMKTYSTMRLHEPDFFIGDTIYADNPIPPEKRDVARTLEEYRGQDDHEVLNNWSASTDLSDDPRYPEKDVAVYAARAARA---EMTAIRTLPTEPGRIFRKIAYGPLLDVFFVDLRSYRGPNQEEGGLFGWRQADWLKRELAASSATWKVIAC................................................................................................................................................................................. 357
9 -6.860[U] KOG3317 Translocon-associated complex TRAP, beta subunit  ali follow..  12  1MVLNHRESGCLLRLLLSCTEILDKEIPKLQMFKHLLTLFALCAVFSTCLSEDETRARSKQILNKYLVEKSDLLVNVGSGTKVRLVDSGFHPEAF--------DVVGGQPTAVVDRIAPQTNFTHVLVVRAFGYF-YKAVEESETLQLAVSSEPGEGGIVNLNEYNKRFSSHFFDW................................................................................................................................................................................................................................................................................................. 186
10 -6.600[S] COG1430 Uncharacterized conserved protein  ali follow..  11  39......................................................................TIETTSGKTQDFVA--ELALDDAQRSQGL-----------MFRKSMPPENGMLFDFGETRAVAMWM-----------------------RNTLIPLDMLFIAGDGRITHIHENAVPHSEAIISSRGPVKFVLELNGGAAKRYGIKPGDMVRSAQIGNRK........................................................................................................................................................................................................................................... 161
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.