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Query: [R] COG2248 Predicted hydrolase (metallo-beta-lactamase superfamily), from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MILGLPVGSRGSLAWEWRRTVDPQVPGSNPGRGTTRILTTFKAINMKVIPLASESLGVRSLALFLKIGKVGILIDPGVALGPKRYALPPAQAEMKALSLAREKIQEYAKKAQIVTISHYHYDHHTPFFEGIYESSSVEKAREIYAGKLLLIKHPTENINNSQKKRAHEFLKNAKEIAKDIKFADSQSFDFGSFTIEFSPPVPHGREGSKLGYVLMVLVDDGKKSVLHASDTQLINDKAVEWIIEKNPDILIAGGPPTYLAHRVGNVKEIGMKNINRIISETNAKIVLDHHIIRDKGYERFFSELDERPLTFAEFLGKESAPLEAYRRELHKLEKGEEVEVPGGIKKFLKGLKLast
1 -104.000[R] COG2248 Predicted hydrolase (metallo-beta-lactamase superfamily)  ali  100  1MILGLPVGSRGSLAWEWRRTVDPQVPGSNPGRGTTRILTTFKAINMKVIPLASESLGVRSLALFLKIGKVGILIDPGVALGPKRYALPPAQAEMKALSLAREKIQEYAKKAQIVTISHYHYDHHTPFFEGIYESSSVEKAREIYAGKLLLIKHPTENINNSQKKRAHEFLKNAKEIAKDIKFADSQSFDFGSFTIEFSPPVPHGREGSKLGYVLMVLVDDGKKSVLHASDTQLINDKAVEWIIEKNPDILIAGGPPTYLAHRVGNVKEIGMKNINRIISETNAKIVLDHHIIRDKGYERFFSELDERPLTFAEFLGKESAPLEAYRRELHKLEKGEEVEVPGGIKKFLKGLK 352
2 -41.300[R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I  ali follow..  13  2.........................LLGCAMAFDSDTRSRESNRNFRVKIWGARKYGGNTICIEVRCGDHVLLFDAGSGLHPAG-----------------LALRAEGITDVNLFFSHCHYDHIVGFPYFKPFY-NSSNDVAIWSGHLAGSMTTREMLKDFMSPPWFPVLEICCAKIATRDFKAGDVLDVHPGLSIRTGMLNH------PGNAIGYRLDWEGKSLAIITDTEHEPSSIDETVLDRDVDLFLYDAMFTDEEGLYRGYGHSSWQQAIRLAKLADAKNVGFIHHAPSDDIEKQAKAEFNGAFAAMDGQVIEI................................. 292
3 -37.100[T] COG5212 Low-affinity cAMP phosphodiesterase  ali follow..  10  2......................HAALEIKEAEFQTDQVVGLVENSFTLYSLGGGPLESCCSSHLISDGQEIISLDGGSHLSALVELIQSKHLSVDSWSSYAKAWHLSEQRIKTFLITHCHLDHIYGAVINSAMFGPQN-PRTIVGLNYVIDTLKKHVFNNLLWPSLDK-----AGFINFQVVEPSMYTSLTTLSILPF-PVNHGSSQELKSSAFLFRNNLSDRYFLAFGDVEPDMRACSSLIAQRKLSHILIECSTPDIPD-TLLFGHFCPRHLVNELCILQLTCLLTHLKSHPLQSANPADVILEQLESLSSKSSLSVTFKILQRGQFYK..................... 345
4 -28.200[R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III  ali follow..  14  1.............................................MDIQFLGTGAG-RNVSSLALKLINEVWLFDCG-----------------EGTQNRILETTIRPRKVSKIFITHLHGDHIFGLPGFLSSRAEEQTDLEIYGPQGI-KSFVLTSLRVSGSRLPYRIHFHEFDQDSLGKILETDKFTVYAEELDHTIFVPFGPLFGKIKNGQDLVLEDGGKIITILGDTRKTGASVR---LAVNADVLVHESTYGKDEKIARNHGHSTNMQAAQVAVEAGAKRLLLNHISARSKLKKDAATIFENVHVVKDLEEVEI................................. 309
5 -26.000[J] COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing  ali follow..  11  3............................................................SVISSEIGVSKKLIDLGVLALRQRNSRGNFKPHVSIRFRNNARSPGKQPQPDAYLITHAHSDHHGKSAMLSPRAVCTDKTATALEIR-------------------------HDRKYVGSMCRLGDEIEIEGVRVKTY-PTAH-----TAGAAAFYWENDVGTRILVTGDVKNASKLP-------PCDVLITEANYG-DPEDPSCHFADDLESMKCALFESGPVAFGAYEFGKAQRAVELMRGFGYEGIRMEARTRALTRSMLEDAGELAGIDSRGEDEV............ 256
6 -25.900[A] KOG1137 mRNA cleavage and polyadenylation factor II complex, BRR5 (CPSF subunit)  ali follow..  14  1........................MASSSTSLKRREQPISRDGDQLIVTPLGAGSEVG-RSCVYMSFRGKNILFDCGIHPAYSGMAALPYFDEID------------PSSIDVLLITHFHIDHAASLPYFLEKTTRVFMTHATKAIYKLLLTDYVKVSKVSVEDMLFDEQDINKSMDKIEVIDFHQTVEVNGIKFWCYTA------GHVLGAAM-FMVDIAGVRILYTGDYSREEDRHLRELPQFSPDICIIESTSGVQLHQSRHIREKRFTDIHSTVAQGGRVLIPAFALGRAQELLLILDEYWANHPDLHNIPIYYASPLAKKCMAVYQTYI.................. 296
7 -25.300[A] KOG1136 Predicted cleavage and polyadenylation specificity factor (CPSF subunit)  ali follow..  17  2...........................................PDIKITPLGAGQDVG-RSCLLLSMGGKNIMLDCGMHMGYNDERRFPD--------SYIVPEGPITSHIDCVIISHFHLDHCGALPYMSEIVGPIYMTHPTKAIAPILLEDMRKVAVERKGESNFFTTQMIKDCMKKVIVTLHQSMMVTDLEIKAYYA------GHVLGAAM-FWIKVGSQSVVYTGDYNMTPDRHLAWIDKCRPDLLISESTYATTIRDSKRCRERDFKKVHECVAKGGKVLIPVFALGRAQELCILLETYWER............................................. 258
8 -24.800[R] COG1782 Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain  ali follow..  12  174.........................................DEKWVRVTFLGGSREVG-RSCYLLQTPESRILIDCGVNVSNLSSTPYLY-----------VPEVQPLDALDAVVITHAHLDHCGLVPLLY-YRGPIYLTPPTRDLMVLLQLDFLEVAGREGTNPPYSSNLIREALKHTITLDYGVVTDISPDVRLTFYNAGH-----ILGSAAHFHIGEGHYNIAFTGDFKFEKTRLFD-TNFPRLEALVMEATYGGPNDFQPSRKEAEIEVINRTLDRGGKVLIPTFAVGRSQEVMIVLEEAMREKRLRETYVYLDGMIYEA--TAIHTAYP.................. 455
9 -23.700[A] KOG1135 mRNA cleavage and polyadenylation factor II complex, subunit CFT2 (CPSF subunit)  ali follow..  12  2..........................................TSIIKLKVFSGAKDEGP-LCYLLQVDGDYILLDCGWD---------------RFGLQYFEELKPFIPKISAVLISHPDPLHLGGLPYLVSKCAPVYATVPVYKMGQMFIYDMVYSHLDVEEFEHYTLDDVDTAFEKVEQVKYNQTVVLSGVHFTALPA------GHMLGGSIWRICRVTGEDIVYCVDFNHKKERHLNGC--NRPHLLITGAHHISLPQMRRKDRDEQLTKILRTVRQKGDCMIVIDTAGRVLELAHLLDQLWSNA-VASSVVQFAKSQLEWMNEKLFKYDSSSARYNPFTLKHV..... 308
10 -22.700[R] KOG2121 Predicted metal-dependent hydrolase (beta-lactamase superfamily)  ali follow..  14  462......................EKLWLSECNTVLPNCLEKIRRDDMEIVILGTGSS-RNVSAIFIDLSRGSLLLDCGEG-------------TLGQLKRRYDGADEAVRKLRCIWISHIHADHHTGLARILALRSKLLKGVTVVGPRPLFLDAYQRLEDLDMEFLDCRSTTATSWASLESGGEAEGSLFTQGSPMQSSFPVVH---PQAYGVVIKAA-QILGWKMVYSGDSRPCPETVE---ASRDATILIHEATFE-LIEEALAKNHSTTKEAIDVGSAANVYRIVLTHFSRYPKIPVIDESHMHNTCIAFDLM-ADLHVLPKVLPYFKTLFRDEMVEDEDADDVAMDDLK 833
11 -22.500[R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily  ali follow..  12  2...........................................SNIKITPLGGVREFGK-NMYLVEVEEQIFVLDAGLKYAEMDQL------GVDFVIPDITYLLENADRVAGIFLTHGHADSIGALPYIV-----SELKVPVFGSE----------LTIELAKINVKNYADSRKFNDFHVVTEDTEIDFGKAVISFF-STTHTIPES-----LGIVISTNDGNIVYTGDFRRTNMRRLAEIGNSGVLALLSSSPNALSTMQSASEHEIY-EKIYDYIDDNEGRVIIAGNLGRIQQTIDAAIKLGRRVAFTGEDMDQIIETATR............................ 265
12 -22.300[R] COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II  ali follow..  12  1........................................MGRMVVKVTIVFENHAGYHGFSALVESNGYKVLVDTGTD---------------KVLLNNMHELGIDANDIDVLFITHGHYDHTGGLKEFL----KERSEPIEVYAHPGIFDERIALKPRKRDIGIPFQRKELEELGARFNLSPEPLEFLPGFISSGEIKRVTWDRAVGYFPDGALIVEGSKGLVVISGCGHSGIINIARHAMELRGSKILIGGFHL------RGAKKELLDDVVTNMKELGVNALYPGHCTGIEEFSYLWSKLDNVEGIY---VGKEIKI............................... 272
13 -20.800[R] KOG0813 Glyoxylase  ali follow..  14  30...........................................................TNTYLLGSGSRRILIDTGDEDVP------------QYIAHLGDVLQQEKASIDTILLTHWHHDHVGGVKSIVGTKLAEKDCRVF----------------KFGRTDAPDVCPEIPTDIKLHPLAHNQEFTTEGANVRVVHTPGHTTDH------VVLAMNEG---TLFSGD--CILGEGTAVFEDLFEYMKSLEKILDIKPQRIFPGHGNVIEEPIGKIEY-----YINHRNQREQQILQFFVQRPNENLQAMDVV-----------KVVYKETPEAAYNVNHHLSKLEKEGK 272
14 -20.600[R] COG0491 Zn-dependent hydrolases, including glyoxylases  ali follow..  11  1.............................................MEILGFAAGPY--KTNCYVVRGENEVAIIDPGM----------------HAHDDLVEYITTNNLSVDKIVLTHGHIDHTRDAGVVAKRFNAP---VYIHPDDAFFLEVYKGSGTKTAMLFDADNMVSPDPESLRD-LVDGETITLAGEEFTLKHAPGHSP-----GCTLIVG-----KEYCFSGDVDAMNESLRTAVLPLDDALQILPGHGPTTTMRAERTGNPFLLAL.............................................................................. 213
15 -18.600[R] KOG0814 Glyoxylase  ali follow..  13  1MLAALKRLSTNQPPTLVSNIRYLSSFGTMSL-----PERQPFSPDFFFRQLFDGESSTYSYLLADLKNGQAVIIDPVL----------------EQAKRDAQLVKDLGFELKYAINTHMHADHITGSGWL------------------------------RKLTGCQSVIAAASGAKADRHLNEGDRIDFGTHVIDALATPGHTNG--------CMTYVIKDQGCVFTGDT-----------------LLIRGCGRTDFQEGCPRNLYENVHS--KIFTLPENFRIYPAHDYKGQMESSVWEEKRYN-------------RLTKDIEEFVKIMENLNLPYPK.......... 252
16 -17.400[R] COG2333 Predicted hydrolase (metallo-beta-lactamase superfamily)  ali follow..  16  76......................................KQLSKPTWQVDTLDVGQ----GLATLIVKNGKGILYDTGSSWRGGSMA-----------LEILPYLQREGIVLEKLILSHDDNDHAGGA---------------------------STILKAYPNVELITPSRKNYGENYRTFCTAGRDWHWQGLHFQILSPHNVVTRADNSHSCV-ILVDDGKNSVLLTGDAEAKNEQI---FARTLGKIDV---------------------------------LQVGHHGSKTSTSEYLLSQVRPDVAIIS........................................ 271
17 -17.000[R] KOG3798 Predicted Zn-dependent hydrolase (beta-lactamase superfamily)  ali follow..  11  80.........................................SESGLFATWLG-------HATVLVDLEGVKFVTDP-------ADRASFTSFAGPKRYRPPPMKLEDLPDLDFAVVSHDHYDHLD--ADAVKRITNLNPQIKWFVP-----------LGLKKWMKNQGIGADGSNTVTELNWGESSEFVKNGKTITIWLPAQHGLSDHNHRLWSGWAVIGENRRFYFPGDTGFCDVEFKKIGEKLGPDLAAIP---AYEPRWFMKSHHINPDEAVEVHKLVRARNSIGIHMGTTEYYLEPRDKLKELMDAREDLKDTSFVTVDMGEI......................... 350
18 -16.900[R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold  ali follow..  12  77...................SEVKDRNPVSPIPVYVIDWNKINSENDSLTWFG-------HSAFLLNVDNKQLLIDPMLGPVVSPVSFVG-RNRYEYSEDIMLHLIDEMPPIDAVLITHDHYDHLDYRSIVKLNNKVSHFFVPLGCSAHLIRWGIPE--------------------EKITELNWWEETEYQGLTVALT-PSRHNPFNIDTTLWGGWVILGNKTRVYTSGDSGYGPHFKQIGDKYGPFDITLIEAQY----DRNWPDLHMVPEQAIQANLDVGGKTMMLMHWGAFTLANHAWNEPIERALKEAKIREVN--IIAPMIGETVLLDSDLQTSPTSWWD....... 372
19 -16.600[S] KOG4736 Uncharacterized conserved protein  ali follow..  14  265..................................TSTAEPKSYVNVTVLQAGSGQVEAVGAITLVNDNGYIVLIDTGAS------------SDTERLLHSLAKESVTLDQIDSVVITHASPGHMGNMNFF------------------------KPILYHSMEYIGRHVTPTELKERPYRKLSGN---------VEVWKTPGHTQHD------LSVLVHNVAGTMAIVGDLIPSEHL--------------LSEKRDVMIEEGVWDNAIKRQNANLIVCMAD--WIVPGH.............................................................. 463
20 -16.100[A] KOG1138 Predicted cleavage and polyadenylation specificity factor (CPSF subunit)  ali follow..  18............................................PFVQSLKWSNLPNF-VPSRDHDPQMDGELKDCCGRVFVDSTP-----------FNLPMDKMLDFSEVDVILISN-YLNMLA----LPYITENTGFKGKVYATEPTFLEELVDYIEVSPKACTFSLKDVQGSLSKVTIMGYDEKLDIGAFIATPVSS----------GYCLGWVLSTAHEKICYVSGSSTLTTHPRNQSALKHADVLIMTGLTQAPTVNPDTKLGELCMNVALTIRNNGSALIPCYPSGVVYDLFECLTQNLEN----AGLNNVPMFFISPVADSSLAYSNILAEWLSSAKQNKVYLPD 334
21 -16.000[L] KOG1361 Predicted hydrolase involved in interstrand cross-link repair  ali follow..  11  151..................................................................LPGTPFTVDA-----------------------------GCVQGCSAYFLTHFHADHYIGL-------TKAWSHGPIYCSSLT-----SRLLRLSLSVNPSSI----------HPLELDVEYTINGIKVTLI-EANH-----CPGAALIHFRLLDGTCYLHTGDFRASKQMQTHPLLFQRVHVLYLDTTYC-NPRYKFPSKEDVLSYVVRITKDFLRKVVGSYSIGKECVYLAIAKALGVKIFANASRRRILQSFGWDDISKNLSTDGKAT............... 373
22 -14.500[C] COG0426 Uncharacterized flavoproteins  ali follow..  10  1.........................MVSMSTTGNAHTENVQHRLTVETVEIAPNQNGTTYNSYLIR-GEQTVLVDTS------------HQKFRQLYLETLKGL-INPKAIDYIIVSHTEPDHSGLV--------------------EDVLQLAPRATVLASKIALQFLEGLVHDPFSKRIVKSGDRIDIGKGHEIEFAPNLHWPD--------TIFSYDRKTEVIYTCDAFGMHFCDNRTFDEDLEAIE--ADFRFYYDCLMGPNARSLLNAMKRMGDLGKIKIIANGHGLFYVADYGYSNLLVQAIGEGIQKTGVAVEMIDLSTAEI....................... 311
23 -14.300[Q] COG2015 Alkyl sulfatase and related hydrolases  ali follow..  11  129...........................................................ANITFVKGDTGWIVFDPLTVP--------------ATAKAALDFVNQELGEVKAVVYSHAHADHFGGVKGIVSQEQVDRGEVPIIAPKGFLNHAVAENVLAGNAMSRRTTYQVSLIAPTKVISEQTETVVIDGVTMEFQNTPGTESPAE-------MNTYFPQFKALWMAEN----------TVGGLHNVYTLRGA-----EVRDAKAWSKYINESIHMYAKEADVMFASHRWGNDNINHFLRKQRDMYGYIHD------QALRLANHGVTINEIQDEFHVPDVLAH...... 403

FFAS is supported by the NIH grant R01-GM087218-01
1 3 9 8 0 4   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Jaroszewski L, Bierzynski A, Godzik A. Multiple model approach--dealing with alignment ambiguities in protein modeling. Pac Symp Biocomput. 1997;:328-39.