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Query: [V] COG2367 Beta-lactamase class A, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKLNRKMTMTVAEQLNAICDVQPFVTRFMVRNLLTGEEIGRGENEETPSGSTRKTSIMMAVLKAASEGRIDLDQPVTYEKRLAEEVASGMFRYMTPGIVISLRDAIAGMMVLSDNVCTKMVLERLTLEEVDGYCKSLGMANTHHRFLIPPLALAADHPLKTVTTTSAADQVLLLQTILDAQSSPEAQAKLGCSPQLCEWAMQTLKNQILRYGIRSRLPFEAMVASKSGRGKRGRMDAGIVYRNGAPSFIITTYTDEVPQVMPDGTPGYTIALETIGRLAQACWDGFKQLast
1 -108.000[V] COG2367 Beta-lactamase class A  ali  100  1MKLNRKMTMTVAEQLNAICDVQPFVTRFMVRNLLTGEEIGRGENEETPSGSTRKTSIMMAVLKAASEGRIDLDQPVTYEKRLAEEVASGMFRYMTPGIVISLRDAIAGMMVLSDNVCTKMVLERLTLEEVDGYCKSLGMANTHHRFLIPPLALAADHPLKTVTTTSAADQVLLLQTILDAQSSPEAQAKLGCSPQLCEWAMQTLKNQILRYGIRSRLPFEAMVASKSGRGKRGRMDAGIVYRNGAPSFIITTYTDEVPQVMPDGTPGYTIALETIGRLAQACWDGFKQ 288
2 -21.100[M] COG1686 D-alanyl-D-alanine carboxypeptidase  ali follow..  16  39..........................SYVLMDGESGQVLENNGDQRLPPASLTKLMTAYIATKEIEAGRIGENDLVTVSEHAWRTGGSRM--FIKVGSQVSVSDLLHGIIIQSGNDASVALAEHIAGSEMNTTAQKLGLTNSHFMDAT----------PNPDHYSSARDMAVLARAIIYG-----AQKEFLWNNIKQPNRNLLLWRDKTVDGL------------KTGHTDEAGYCLVASAVRDGQRMIAVVFGTNSEQA............................ 260
3 -17.700[V] COG2602 Beta-lactamase class D  ali follow..  10  26.SAHEKHLNVSKMNVDDEFKDTDG--TFILHDLQKDQTFVYNRKQRQTPQSTFKVVNAL----------IGLQVKAVRDEYDVKRWDGVKREFESWNRDHTLGS----AMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGIDQF-------LQSSLTISPLEQETFLEKLAKEEL---------FDKPVMKIVKRMMIQEE---------GDHYTLYGKTGTRLTDMG-VGFI-KTEHGSYVFVTNVDDSGTKAKN-------TVDILKKYG......... 263
4 -14.200[M] COG2027 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4)  ali follow..  12  260........................................................AGAILKDELKKADIQIDGNLRRQTIP-----SPAGNVLAQTQSAPLHDLLKIMLKKSDNMIADTVFRTIGADAVRQILRQAGVD-------LGNSIVVDGSGLSRHNLISPATMMQVLQYIAQNDQELNFISMLPLA----------YDGTLRYRGGLHEAGVNGKVSAKTGALQGVYNLAGFITTASGQRMAFVQFLSGYAVPPEDQKNRRAPLVRFESRLYKDIYQN... 481
5 -12.100[V] COG1680 Beta-lactamase class C and other penicillin binding proteins  ali follow..  9  25ITEPEFASDIVDRYADHIFYGSGAT-GMALVVIDGNQRVFPQLDSVVRIASLTKLMTSEMLVKLLDQGTVKLNDPLSITLVNLATHTSALPREQPGGVWPTREQRWKYLSTAKSNLAFDLLLANASGKPYTQLFEELGMKDTTYTPSPDQCRRLMVAERGASPYSTPGDMMRWMQQYLSSDFYQRSNDRMQTLIYQRAQFTKVIGMDVPGKADALGLEGRPGIIQKTGGGGGFITYMAMI----QKNIGAFVVVTRSPLTRFKN........................ 362
6 -11.900[M] COG4953 Membrane carboxypeptidase/penicillin-binding protein PbpC  ali follow..  15  270DKITTTLDAGLQRRLEELAQNWKGRLAMIVVDHTDMRVRGWVGSVDLSPGSVLKPFVYGLAL---DEGLIHPASLLQDVPRRTGDYRPGNFDSGFHG-PISMSE----ALVRSLNLPAVQVLEAYGPKRFAAKLRNVGLPLYLPNGAAPNLSLILGGAG-----AKLEDMAAAYTAFARHGKADPLLERPLMSSGAAWIIRRIMADEAQPLP-DSALPRVAPLAWKTGTSYGYRDAWAIGVNAR---YVIGIWTGRPDGTPVVGQFGFASAVPLLNQVNNILLS.... 566
7 -9.520[M] COG0768 Cell division protein FtsI/penicillin-binding protein 2  ali follow..  12  258.........SLQIYIEKLLSGSRA--AVVVTDPRTGGILALVSNPSYPPASTVKPYIAVSAL---SAGVITKNTSLFDPGWWQLPGSEKRYRDWKKWGHGRLN--VTKALEESADTFFYQVAYDMGIDRLSSWMSKFGYTGIDLSEERAGLMPTREWKQKRHKTATPIQMAKSLMTLINDYKQEDSTQIGSINSGYWEIAKDGMYNRPNGTGRKFFEGTPYKAAAKSGTAQVYSHKLMVAFAPENPTVSVAIILEN------------GGAGPAVGTITRQILDHI.. 609
8 -8.600[M] COG0744 Membrane carboxypeptidase (penicillin-binding protein)  ali follow..  10  320ANFQTMAEDTVKKWHKTLLGEGLSQIALVAIDPRTHFVKALVGGVDSQPGSSFKPFVYYAAF---ATGKFAPDSTVI-DAPVRYRDGNNWYSPRNYDGGFSGAMSIRTALAQSRNIPVIKLGKTIGMNKVVETCRILGIMSPMEPVTSLPLGAIG---------VTPLEMASAYATFANYGWDNTPKPQLVLDPWASAAIIDVMRSVV-TNGTGKGAAIDRPSAGKTGTTSSEKDIWYVGTVPQ---LTTAVWIRDDNRQLASGATGGGKVAPIWRDFMTKALK.... 621
9 -7.280[E] COG2066 Glutaminase  ali follow..  11  33.........IVADYIPALAKVPSDKLGIAVFTNQGEVITAGDAQEGFSIQSISKVLSLTLAMGLINAGAIVVCDMLQSRLSAPRQRLLEFVRQLSGEPQIAYDKVVAASEMMHSNAAIAYLMRSFGNPVLHNYFHACALK------------------------MSCVELAKTFSYLANKGVSVVTGET-VITPTQSKQTNALLADGAGEFAYRVGMPG------KSGVGGGI-----IAVVPG--EMTIAVWSPAL-----DQSGNSLAGTRALELLAQRI...... 311
10 -5.340[K] COG2865 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen  ali follow..  9  15IEFKRELNDSVYKTLSAFANTDGGILLLGVSN--DGKVFGFSGDDSLARSIRHNLRINPPIKVEEIGEKKVVIIDVSKSPVPISFKGRYYKRVGAQTVEMGWEDLQRFFLQKSDSLPSSAALEDLDEETIRKFVHMARNRLPYINENEDVESILDKLGLLEDGKITNAAL------LLFGKEPQRYYIQAKVRIGRFKDPITIIDDKEIGGNLFTQVEEVMKVIMS.............................................................. 237
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Rychlewski L, Godzik A. Improving the quality of twilight-zone alignments. Protein Sci. 2000 Aug;9(8):1487-96.