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Query: [S] COG2512 Uncharacterized membrane-associated protein/domain, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDLLMEMNLRFYIICIAALLTLLASASLALGVPFLEDNNVTATVHGATYAKDTLELLNDTVISINSTPSQSMVAKDGIYSFELAPGDYAITARYYRNNTLIYSKETTFKIEGEGNYVFDLLLYPVSEYPVTEPIQDSYSIDPPETIGIGPSTTDYLPISYLSIVFVLILLLGGGYKFSSKHKNTNKNKFQERKFDIPGILVKVPGRSTGLGVRSESSGGAVSLTEPIIEPAGNPDIETAALNRIPLSPELCEVLDIIRGHKGRITQKDLRSKLDYSEVKVSLMLSELEKRGLIRKLRNGRENILVLVDEEHLast
1 -106.000[S] COG2512 Uncharacterized membrane-associated protein/domain  ali  100  1MDLLMEMNLRFYIICIAALLTLLASASLALGVPFLEDNNVTATVHGATYAKDTLELLNDTVISINSTPSQSMVAKDGIYSFELAPGDYAITARYYRNNTLIYSKETTFKIEGEGNYVFDLLLYPVSEYPVTEPIQDSYSIDPPETIGIGPSTTDYLPISYLSIVFVLILLLGGGYKFSSKHKNTNKNKFQERKFDIPGILVKVPGRSTGLGVRSESSGGAVSLTEPIIEPAGNPDIETAALNRIPLSPELCEVLDIIRGHKGRITQKDLRSKLDYSEVKVSLMLSELEKRGLIRKLRNGRENILVLVDEEH 311
2 -24.200[S] KOG3306 Predicted membrane protein  ali follow..  10  1MTMTSIIRS---SPTLAFIVLQICFIFFASTFPCSSGSEDSYTITGRVKIPPHIAKFSNVKVILNGGQKITFLRPDGYFTFEVPAGTHLIEVSAMGYF----FSPVRVDVSARHRGKVQATLTETRRSLTELIREP............................................................................................................................................................................... 135
3 -17.500[K] COG5631 Predicted transcription regulator, contains HTH domain (MarR family)  ali follow..  22  81.....................................................................................................................................................................................................................................................LSPIEILILHSIRHRDREKKLADICLALDIETHIATYAIRKLEKAGLLTTGKAAKEKTVKITAKGA 147
4 -17.300[KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon  ali follow..  21  1.....................................................................................................................................................................................................................................................MKMKTLFLLIKLAKMGATVTMRELSRELDVSPQTVLRWLEELKEQGYIHKRESRKGTLVELTEKGI 71
5 -16.400[S] COG3398 Uncharacterized protein conserved in archaea  ali follow..  22  185......................................................................................................................................................................................................................................................NATNQRIISEIQNGKC-NTNLALAREIGVSRATISWYVKNLKETGLIDETRSGRSIIYSINPS.. 246
6 -16.100[K] COG1846 Transcriptional regulators  ali follow..  27  40.....................................................................................................................................................................................................................................................LTPSEIHTIDAIGTDEG-LLMKELAERLGVTKGAVSQLVDRLEAKALVRRTA--RGIQVVLTDKGR 107
7 -15.200[K] COG3355 Predicted transcriptional regulator  ali follow..  32  25.....................................................................................................................................................................................................................................................LSKSDVEVLHILLQNGK-MTTDDLSQKLNVTKASISKALNNLLDKGLIQREKAPAEK......... 80
8 -13.400[K] COG3888 Predicted transcriptional regulator  ali follow..  26  4.........................................................................................................................................................................................................................................................RDVLLRELKRARGLIDQFQIEEMMGFSKSTVSEALKDLEEKGIIKRRTIG............ 54
9 -13.300[K] COG1510 Predicted transcriptional regulators  ali follow..  18  29.....................................................................................................................................................................................................................................................MPSTVGRVLGIIYMNRKPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEGRKDLYDVEQD.. 94
10 -13.200[K] COG5625 Predicted transcription regulator containing HTH domain  ali follow..  15  19.....................................................................................................................................................................................................................................................LKKNEIRIYRLLVEKRRGMRIREIQRELGISERSVRTHVLNLYRRGLLKRELVQSGW......... 75
11 -12.700[K] COG1497 Predicted transcriptional regulator  ali follow..  18  5...................................................................................................................................................................................................................................................RKKGELTRQILSEIAMRQPYVRQKDIADKLGVTVQAVSENIKSLIAEGLVESG--SGRSHYKITRR.. 69
12 -12.500[K] COG4190 Predicted transcriptional regulator  ali follow..  20  58............................................................................................................................................................................................................................................TSYDDLMDTLTPRVLELIEAIRQE-EPASINETARVVDRDVKNVHEELSRLAHLGIIFFEEDGQRKRPVVWFDE. 130
13 -11.900[S] COG2469 Uncharacterized conserved protein  ali follow..  17  196....................................................................................................................................................................................................................................................KLSEVEEQILTMVYTG---VDSVSVESILGVTTEELNKMYDRLVNLGLARVVK--IRKEIELTPRGV 257
14 -11.500[K] COG5111 DNA-directed RNA polymerase III, subunit C34  ali follow..  14  73...........................................................................................................................................................................................................................................RLDEAKTVSTMEGDEQIVYSFIKNSGNEIWRKTLTLRTNLHVSVVDRCLKSLESKNLVKSIKKNPTRKIYMLYDLV 151
15 -11.500[K] COG0640 Predicted transcriptional regulators  ali follow..  25  2..........................................................................................................................................................................................................................................................................NEITMQTQADQPKVSSNLAILSEARLVDSIQMGREKIYRIAPEK. 45
16 -11.500[K] COG1777 Predicted transcriptional regulators  ali follow..  10  3............................................................................................................................................................................................................................................DDIDNFIAAIENSTRRIIRMLTQ-FERSYALELSRSIGLSQQAILKQLEMLERANLVTSIGFVPSS......... 68
17 -11.100[K] COG2345 Predicted transcriptional regulator  ali follow..  16  2.........................................................................................................................................................................................................................................GDVVKGNDAHTGDGDTRRKILLILLER-APVIASDIAEQLQLSTVGVRRHLDNLVEENLAEAANPRQNP......... 69
18 -11.100[K] COG3432 Predicted transcriptional regulator  ali follow..  15  40............................................................................................................................................................................................................................................................MFDILRNCEPKCGITRVIYGAGINYVVAQKYLDQLVKVGALNIKTENDRKIYEITEKGK 98
19 -11.000[K] COG1378 Predicted transcriptional regulators  ali follow..  18  35.....................................................................................................................................................................................................................................................FRDYEARVYATLATR-GEATASEIHRVSGVPRNKVYEVLRSLEDRGMIETIKSSPAVFRAIDPES. 98
20 -11.000[K] COG4742 Predicted transcriptional regulator  ali follow..  18  12......................................................................................................................................................................................................................................................SQKRRDLLLLLGE--EPRTMEDIKVLLDVSPTAILPQIKRLTDSNLVIQKNMGE........... 70
21 -10.900[K] COG1695 Predicted transcriptional regulators  ali follow..  15  1.....................................................................................................................................................................................................................................................MDRYAIKALVLLSKKPLYQMSKEISTGVQVSHGTLMPMIRKLLQERYIDFETRGREKVYHLTERGS 68
22 -10.900[S] COG3388 Uncharacterized protein conserved in archaea  ali follow..  20  16.....................................................................................................................................................................................................................................................TLKRHISVINVLLRE-QPIGIIKLSQETGIPEHKIRYSLRILEQENIISPSREG............ 68
23 -10.800[K] COG4738 Predicted transcriptional regulator  ali follow..  10  17....................................................................................................................................................................................................................................................KMGEVEYEMVELLRRLNDEISSQRIEMVSGLRQPEVSIAMRYLRENEWVDMREEKKNH......... 89
24 -10.800[K] KOG3233 RNA polymerase III, subunit C34  ali follow..  17  78...........................................................................................................................................................................................................................................DSQNAGKMKGSDNQEKLVYQIIEDAGNKIWSRDIRYKSNLPLTEINKILKNLESKKLIKAVKAASKKKVYMLYNLQ 156
25 -10.800[S] COG4861 Uncharacterized protein conserved in bacteria  ali follow..  13  117...........................................................................................................................................................................................................................RGRRSAVSAQPGTLGDGLHSDGPRNPFTPKRAQVVCVLLDAPQLVPLRAIAASAGVSVGMAKETMDTLRTTGFFEHLGSRRR.......... 200
26 -10.700[K] COG5340 Predicted transcriptional regulator  ali follow..  20  2.........................................................................................................................................................................................................................................SSTQETQTIRQGLSTRESRLLSHLAAEGHQISIDDVEATLEVAPNTAREIASRLTEKGWLDRLLPGRYLIIPLAAGEE 80
27 -10.600[K] COG1414 Transcriptional regulator  ali follow..  26  2..................................................................................................................................................................................................................................REPTLETDDRYRAPALDKGL-----DILELLASVDGGLTQAEIAKHLDRSPNEFYRMLDRLVKRGYVTKLDGDRYSL........ 73
28 -10.400[K] COG1802 Transcriptional regulators  ali follow..  14  22.........................................................................................................................................................................................................................................................RQAIMSGRFTPGERLIERELCETLGVSRTSIREALRRLEAEKLVSIVPHKGPIVAIISRQE. 82
29 -10.300[K] COG2188 Transcriptional regulators  ali follow..  24  13..........................................................................................................................................................................................................................................................EKVKDYILANTGRWSENELVASLGVSRMTVHRALRELTAAGFLIRLQ-GVGTFIAPPRPQS 81
30 -10.300[K] COG1522 Transcriptional regulators  ali follow..  19  5....................................................................................................................................................................................................................................................ELDKIDRKILEVL-QSNGRLTNLEVAERVNLSPSPCLRRIRRLEESGVIRQYKIGLG--VRLEKQGG 81
31 -10.300[S] COG4344 Uncharacterized protein conserved in archaea  ali follow..  16  13.....................................................................................................................................................................................................................................................NDYDMLRVLKHFTIA-HVDYAKNITRYTEIPQMRVREYLKRLKDLGLLDYYTNT............ 65
32 -10.100[K] COG1321 Mn-dependent transcriptional regulator  ali follow..  19  14..........................................................................................................................................................................................................................................................ETILYLITKNQGPAKTKQIAEELNVSSPSVTEMIKKLHSMGFVEYKPKGAEEAVRIKRKHQ 82
33 -10.100[K] COG3327 Phenylacetic acid-responsive transcriptional repressor  ali follow..  25  23............................................................................................................................................................................................................................................................ISSLYSHRGGEIWLGSLAAGLGFGERFVRTALFRLNKEGWLDVSRIGRRSFYSLSDKGL 88
34 -9.960[T] COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases  ali follow..  23  159.......................................................................................................................................................................................................................................................TAIERAAYLIAFLYRKVTQQHVADTLGLSIVHTNKTLRKLVDRGLIR-----IDKGCLVLDEAG 232
35 -9.850[K] COG2186 Transcriptional regulators  ali follow..  20  19..........................................................................................................................................................................................................................................................DQIRELIDVGGTRLAERELAQKLGVSRPSLREALIALEIDNTVE-IRMGSGVYVS...... 77
36 -9.570[K] COG1675 Transcription initiation factor IIE, alpha subunit  ali follow..  16  2...................................................................................................................................................................................................................................KAETTTGVEELLNELVGRAAGEVGLILFSLGIE-GEFTDDQLSLELGIEINEIRKALFALYEIGLADYVRRRDDE......... 75
37 -9.430[KG] COG1349 Transcriptional regulators of sugar metabolism  ali follow..  17  5.......................................................................................................................................................................................................................................................QRQAAILEHLQKQ-GKCSVEELAQYFDTTGTTIRKDLVILENAGTVIRTYGG............ 55
38 -9.340[T] KOG4603 TBP-1 interacting protein  ali follow..  15  10......................................................................................................................................................................................................................................................AGAAGILLRYLQEQNRPYSSQDVFGNLGLGKAVVVKTLEQLAQQGKIKEKMYGKQKIYFADQDQ. 77
39 -9.320[K] COG3682 Predicted transcriptional regulator  ali follow..  12  2....................................................................................................................................................................................................................................................HITAAEAHVMEAL--RRSPLSADELVAEVSWGEATVKTLINRLLKKKAIKSERAEGKHGYRVDRSA. 72
40 -9.220[S] COG4519 Uncharacterized protein conserved in bacteria  ali follow..  9  12...........................................................................................................................................................................................................................................................YLALLV-ESLERPNVPKLIEKTGWPRRTIQDVIKAMPGIGIELN................ 54
41 -9.200[S] COG3373 Uncharacterized protein conserved in archaea  ali follow..  13  16......................................................................................................................................................................................................................................................SELRRKVLFYLLSIYPYSYLSEISRAVKSDPSNVKGCLESLIGLGLVIVEQSKNGKYFKINPEIV 92
42 -9.040[J] COG4901 Ribosomal protein S25  ali follow..  14  3............................................................................................................................................................................................................GKKKPTLSQLAKKAEKEKAQQAQKAKKEVKKEETPAKRTIQVLDEKQAIAKEVQNMR--ITPYEIASKYGIKMSVAFKVLRNLKERGDLVLVAKGHRTEIYVPAKR. 109
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.