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Query: [R] COG2516 Biotin synthase-related enzyme, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRVRLSYGTAVSMGLIRAKLLARPTTAYLMTYYEGRCINDCKFCAQARSSRANLEMLSRVVWPAFELETVLKNFSKGNFKRICLQTIDYPNMLSDVFSLLEELSKLNVPISLSITPVPRSELEEFSTLGVDYIGVGLDAASERVYKDVKISRYSWDDMWKFFDDVLSVFGKGRAVVHLIVGLGETDKEIVETIGEVYKKGGIVSLFAFTPIKGTQMENFSPPPLERYRKIQVAHYLIKTGEAELEDFEFDEFGNLIGLPKTEVPPIAYVTQGCPWCNRPYYNERPGREPYNYPSVEMVRKRKLast
1 -105.000[R] COG2516 Biotin synthase-related enzyme  ali  100  1MRVRLSYGTAVSMGLIRAKLLARPTTAYLMTYYEGRCINDCKFCAQARSSRANLEMLSRVVWPAFELETVLKNFSKGNFKRICLQTIDYPNMLSDVFSLLEELSKLNVPISLSITPVPRSELEEFSTLGVDYIGVGLDAASERVYKDVKISRYSWDDMWKFFDDVLSVFGKGRAVVHLIVGLGETDKEIVETIGEVYKKGGIVSLFAFTPIKGTQMENFSPPPLERYRKIQVAHYLIKTGEAELEDFEFDEFGNLIGLPKTEVPPIAYVTQGCPWCNRPYYNERPGREPYNYPSVEMVRKRK 302
2 -49.400[R] COG4277 Predicted DNA-binding protein with the Helix-hairpin-helix motif  ali follow..  16  1......MGSTEGSGICHAYAPDGRCISLLKILLTNFCIYDCAYCINRSSSNVERARFT----AEEVVWLTLEFYRRNYIEGLFLSSGIIRSTMEEMVRVARELRVFRGYIHLKSIPEASPRLIEEAGLYADRLSINIELPTDSGVSRFAPEK-QPANIRRSMADIRLKFAPAGQSTQMIVGAGADDSTILSTSARLYGS-RRVYYSAFSPIPDSSKNLPIKPPLMREHRLYQADWLYRFYGFDIGEITAIGGDGMLDLDIDPKLAWALKQR-VNVADREMLLRVPGFGTKTVASILSSRRFR 322
3 -46.200[H] COG0502 Biotin synthase and related enzymes  ali follow..  14  35.....ELVYRATQVHRKHFNPRAIQLSTLMSIKTGGCPEDCSYCPQSARYHTGVQ--NQQLLDVDEIVAKAKIAKARGAGRFCMGAAWRGPKPKDVTEIIKAVKSLGLETCGTFGLLQDGMAEDLKEAGLDYYNHNLDT-APEHYAEVIGTR-RFDDRLSTLGKVRKAG---KVCCGGIVGMNETRKERAGLIASLANLDPSVPINQLVKVEGTPLADAEELDWTEFVRTIAVARITMPKSLSAGRSGMTEEMQAMCFMAGANSIFY................................... 299
4 -44.600[H] KOG2900 Biotin synthase  ali follow..  14  37....IDLIFRAASIHRKFHDPKKVQQCTLLSIKTGGCTEDCKYCAQSSRYNTGVKATK--LMKIDEVLEKAKIAKAKGSTRFCMGSAWRDLNGRNILEIIKEVRSMDMEVCVTLGMLNEQQAKELKDAGLTAYNHNLDT-SREYYSKIISTR-TYDERLNTIDNLRKAG---KVCSGGILGLGEKKHDRVGLIHSLATMPTSVPFNLLVPIPGTPVGDAERLPIHPFLRSIATARICMPKTFAAGRNTCSESEQALAFMAGANAVFT................................... 306
5 -40.700[H] KOG2672 Lipoate synthase  ali follow..  13  115....................KDKSRATATIMLMGDTCTRGCRFCSVKTSRRPG-------PLDPNEPENTAEAIKQWNLGYIVLTSVDRDDLTDHIAKTIQKIKEILVEALTPDFSGRMDLVEIVAKSGLDVFAHNVETV-EELTPFVRDRRATYRQSLSVLKHVKKTCPHLITKTSIMLGLGETDAEILTTLKDLLEHNVVVTFGQYMRPTKRHLKVQEYVHPKKFEYWKEVAEKL................................................................. 332
6 -38.800[H] KOG2876 Molybdenum cofactor biosynthesis pathway protein  ali follow..  14  66......................GRQHSYLRISLTEKCNLRCQYCMPEEGVPLTPKA---NLLTTEEILTLARLFVKEGIDKIRL-TGGEPLIRPDVVDIVAQLQRLEGLRTIGVGINLARLLPQLQKAGLSAINISLDTLVPAKFEFI-VRRKGFHKVMEGIHKAIELGYN-PVKVNCVVMRGLNEDELLDFAALTEGLPLDVRFIEYMPFDGNKWNFKKMVSYKEMLDTVRQQWPELE-KVPEEESSTAKAFKIPGFQGQISFITSMSEHFCGTCNRLRITA................... 322
7 -38.700[H] COG0320 Lipoate synthase  ali follow..  13  61...KNGLHSVCEEASCPNLSECFNHGTATFMILGAICTRRCPFCDVAHGRPVT--------PDANEPEKLAQTIQDMGLRYVVITSVDRDDLRDGFADCISAIRAKNETLVPDFRGRMDRALDILTATPPDVFNHNLENV-PRVYRQVRP-GANYDWSLKLLERFKEAHPDIPTKSGLMVGLGETNAEIVEVMHDLRRHGVMLTLGQYLQPSRHHLPVQRYVSPAEFDEMKAETHAACGPFVRSS......................................................... 308
8 -37.300[HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes  ali follow..  14  26FSLPIHAVGRIADEIRKVKCGDLVTFVDTNINYTNICLSKCRFCAFYAREKG-------YVLSHEEILRKVGYAVKMGATQIMLQGGMNPDLGLEFEELFRKIKAEIVFLAKLERSSIREVLDRLKAAGLDSLGGGAEILVDSVRRKISPNKCSSDEWLRVMETAHSLN---PTTATMMFGHVESDGDIVEHLIKIRELQETGGFTAFIPWTFQPGNTKRPVSPLRYLQVLAISRIVLNNFIQASWLTQGFEIATLSLFFGANDFGGTMLE............................... 312
9 -37.000[H] COG2896 Molybdenum cofactor biosynthesis enzyme  ali follow..  15  1..MRNVQAQPLVSPTEPMIDPFGRAVTYLRVSVTDRCDFRCTYCMAEHMTFLPKKDL----LTLEELDRLCSVFIEKGVRKLRL-TGGEPLVRKNIMHLIGNLSRLDELTLTTNGSQLARFAGELADCGVRRINVSLDTLNPEKFRTI-TRWGDLSRVLEGIDAAQKAGIHVKI--NAVALKDFNDAEIPELIRWAHGRGMDVTLIETMPMGEIEFDRTDQLPLSQVRADLASQFTLADIPYRTGG---ARYVTISETGGRLGFITPMTYNFCESCNRVRLT.................... 277
10 -32.500[S] COG1856 Uncharacterized homolog of biotin synthetase  ali follow..  15  63.............................ISVTGRNCELMCDHCASKILWHMIPAT------TPEELVKVGEDLKKKGIEGVLISGGSDKNGFVPLWDFFDAMKELGFLLTCHVGLVDEDYVEKLKEANVDAVLLDIIGDNETIAQVYKLPHKSVEDYDRSLRLLKEAG---RIVPHVIIGLYGKIKGEYNAIDMIAKYEPALVLVVVMPYYGKAFQLLPPPSSEESAQVILYARKA................................................................. 269
11 -30.600[R] COG2100 Predicted Fe-S oxidoreductase  ali follow..  10  111......................DRGTNLIQVRGSTGCNMRCIFCSVDEGPYSRTRKLDFVVDYLLKWFDWVAKEKGKGLEAHLDAQG-EPLLYPFIVELVQALREHPHVSVISMQSLNDKLVEELAEAGLDRVNLSIHSLDPEKAKMLMGIKYDLNHVLEMAEALVNAGIDVLIAPVIMFGV--NDDEAEAFIEFARRIGAGKRWPALGFQNYIPYKFGRNPVIAKPVPFKEFYRWLRELEEKTGMKPL----ILKPHHFGMYPRPFIPLAFKREVVKAEVI.................... 371
12 -26.100[R] COG2108 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme  ali follow..  11  11IMVQKTPYYSYVVGELPKGCQYCVRGEKLVLFVTGVCPRNCFYCPLSPWRRKDVVYANE--RPVRSEKDIIEEAKIQDARGAGITGGDPLARLSRTVEYIRLLKKFHIHLYTTGILASEEALEKLYDAGLDEIRFHPDLFQPN--------SKFFEREIENMKKAFDFGWDVGGEVPAV----GFEDRIKWFASLLDKLGAFLNINELEFSETN........................................................................................ 217
13 -24.400[R] COG5014 Predicted Fe-S oxidoreductase  ali follow..  10  67..................RFRYSLYYGGIVTADTVGCKFLCAYC-WNYFRNLRPKRAGDFLSPEEVAERLLEISKKRKCDLFRISGAEPILGRRSAEHVRKVIELVNNTFILETNFGFDPSLVDLFVNLNVLIRVSVKGWDEESFEKITGASG--EYFRYQLKALEHLHGKVHFWVAVVYDL-FREKGLKELEKRLPPCRIEKEYLEMYP............................................................................................ 258
14 -23.900[R] COG1964 Predicted Fe-S oxidoreductases  ali follow..  13  95.....................HKSHTALLNIVLTNRCDLACWYCFFYARRAGYVYEPT--IEQIREMVRKAKNMKPIGCNAVQL-TGGEPTLRDDLIDIIRMIKEEGYHIQLNTNAEDPDFALRVRVAGVNTVYLSFDGVDEKTNPKN------HHEIPKILENCRRAQLGLVLVPTVIKGV--NDHQLGDIIRFAAENIDIVRGVNFQPVSLVGSMPRKEREQFRITIPDCIKAIEEQTNGEIGRYPVPSVVPISRFVEALTGQPQYELTTHFACGMATYIFKDNGRLIPITRFVDVEG.. 370
15 -23.100[C] COG0731 Fe-S oxidoreductases  ali follow..  14  72.............FCYKSKFYGVQSHRCLQMTPTLICNQRCLFCWRPTEVPVPAPG--EWDSPEKIVEESIACLEGNEPNNVAISLSGEPTFYPYLPELIEEYEKRGFTTFLVTNGTVPSMLAKVNP---SQLYMSLDAPDLKTYLRVCQSPALWDRINESLDIMKDKCSRTVIRTTLVKGENIFNKGYAELIKRASPDFVEIKAYMHLGFSRLRLDRSAMPTHEEVLEFSKE..................................................................... 308
16 -22.400[O] COG1180 Pyruvate-formate lyase-activating enzyme  ali follow..  7  76..............................SFSTYGCNWMCMYC-----QNYDISQRRKAEGVELSPEEIVELAMGYDVDGMTYTYNEPAIFSEFAHDVGIVAKRYGLFNTMVSNGYWTPNLVDYVKDFLDAVTIDFKGNGEQKFLRRYTGATSAEPIIETASELSKKGIHVEITDLIIPQIGDDLQAAKQLLTKLYDQDIPIHFLRFHPD---KLNYIPWTPVETLERHYKLNLVIRRYSFDILEWHLTEDMR------------------CKFCGYK....................... 330
17 -20.900[R] COG0535 Predicted Fe-S oxidoreductases  ali follow..  12  10...........................HVDFNLTNGCNLACSHCHSASGPKLDNE------LKTEEILQTIDALHIIGALKIAF-AGGEPFIRRDIFNILSHACSWGISVITNGFYLNSLTVEKLKACPNLSINISVDGSTPAGYSTLRKQQPLFERVLSGIDNVVRSGMSNSVNFTI---TKATLHDIEATYELVVDR-DNMVAIKFFPGYGKEHLDLYEIPYDMWDEHFV...................................................................... 219
18 -20.900[C] COG1032 Fe-S oxidoreductase  ali follow..  18  245.............................MVEVMRGCGVGCDFCEVTLRPLRYM--------PLNMIVDEIKINVAGGVDNAWLHSDE-EPNEEALSELFSTVMSVPTHGRISIPAGYPEMMEKLSKINWIGIQTGLETGSEELAKKHMPNKSWQDIVWQGVFVETRNY---RSAFTIQVGQGETPEDLWETIALINKLSGRPFEFTVTPLVNVPLGRIKS................................................................................. 464
19 -19.500[R] COG1244 Predicted Fe-S oxidoreductase  ali follow..  11  4..............IGEDNVAGEPGKVLYVILPTIGCYRPCYMCSYPAQAPKKTSQERILSHFLEAVHKIKGKDDRFSIRIFTSGSDSAEVRRDTRIRIFREISKLDNVYEVVVETRSERELAEMVEDKWFEVAIGLESANDDIADVSINKGSTFNDFVRASEIIHNAG---KVKTYLLLKPFLSERDAIEDVKFSIEKTDTFSINLTNIQKGTLYEEYRTPWLWSVVEVLR...................................................................... 244
20 -19.300[KB] COG1243 Histone acetyltransferase  ali follow..  11  3..............VIRKPTRMLSGVTIVSIMTH-SCPHKCVFCPGGVDVDTPQSYYGREPTLMRAIENDYDPFHQPSKVELIIMGGTFLSLPIDQDWFVTYALEVGMTIETKPDWAKEWHADQMLRLGATKVELGVQTVYDDILKFT-NRGHTVKDSIESTRILKDSG---KVVYHVMLGLKSDPDKDLEAFKTIFSDPNFLKIYPTLVVETAPLANLKPYGTETLIELISEMYRYIPKWVRVMRIQRD.................................................... 293
21 -19.100[R] COG1242 Predicted Fe-S oxidoreductase  ali follow..  17  28......................GQKTYKVALDGGFDCPNRCTFCSAAGSGDFAGNRALDLKVQFQQVRDKMQTKWKDGKCIAYFQAFTTHAPVAELREKFETVLNEPGVVGLSIATRPDEYLAELNERTYLWLELGLQSAHDETGRLINRA-HDYDCYLEGVRKLQKHN---RICTHIINGLKETPEMMMETAQKVVESGVGIKIHLLHLLKGTPMVEDEFLTRDGYVNLVADQLEILPPEMVIHRITGD.................................................... 276
22 -19.100[C] COG1031 Uncharacterized Fe-S oxidoreductase  ali follow..  16  178..............................IEVSRGCERRCSFCTEPLLHGRLKSR------DVQAILKEIESLYRAGCRAFRFGRGSDRNGGKPSPEILEELYSG--PSYLVTYEKECRKIVETYNTPGDVFSFGVESFDENVLKKNN-VQGSPEEFLKAIAVVNEIGGKLLPGVNLIFGLGETEETLKKNYSYLKRI-RRINIRKLLAYPGTPVYEYLKNKKHRIKS......................................................................... 410
23 -18.600[H] COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases  ali follow..  9  18....................................CVQKCPYCDFNSHAQKGHIPEQDYIAHHQDRQRFQDSIQDRSLHSIFIGGGTPS-SAEGIHTLLSGVAQIEITLEANPGTAEAERFKGYVQAGVTRISMGIQSFNDDKLVRL-GRIHNAQEAKSAVGFAKLSGLK-SFNLDLMHGLNQTLEEALSDLQQAIALEPHLSWYQLTIEPNTMFAYRPPVLPDDDALWDIFEQGHQ................................................................ 232
24 -18.200[BK] KOG2535 RNA polymerase II elongator complex, subunit ELP3/histone acetyltransferase  ali follow..  12  105..................................NMTGNICVYCYEPTSMRAIRSRYDPFLQTRHRVEQLKQLGHSVDKVEFIVMGGTFMCLPEERDYFIRNLHDIGITIETRPDYCLKRHISDMLSYGCTRLEIGVQSVYEDVARDTNRG-HTVRAVCESFQLGKDAG---KIVTHMMPDLNVDFERDIEQFIEYFENPAFLKIYPTLVIRGTGLYELKSYPPSMLVDLVA...................................................................... 352
25 -17.900[R] KOG4355 Predicted Fe-S oxidoreductase  ali follow..  18  208..............................ISISTGCLNACTYCKTKHARGNLASY------PIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDLPTLLWKLEVIPEGAMLRLGMTNPPYILE-HPRVYAFLHIPVQSASDSVLMEMK-REYCVADFKRVVDFLKEKVPGITIATDIICGFGETDQDFQETVKLVEEYKPSLFINQFYPRPGTPAAKMEQVPAQKKQRTKDLSRVFHS............................................................... 426
26 -17.700[J] COG0621 2-methylthioadenine synthetase  ali follow..  17  151..............................VSIMEGCSKYCSFCVVPYTRGEEFSR------PLNDVLTEIANLAQQGVKEINLLGQNVNAYRGEFATLLRIVHEIPGIERMRFTTSHPREFTD-LPKLVSHLHLPIQSGSDRVLSAMK-RGYTALEYKSIIRKLRAIRPDLCLSSDFIVGFGETEREFEQTLKLVKDIADLSFVFIYSPRPGTPAANLPDPHEEKVRRLEALNEVIEAETARINQTMVGTVQRCL.............................................. 388
27 -17.600[T] KOG2492 CDK5 activator-binding protein  ali follow..  12  226..............................ISIMRGCDNMCTYCVVPFTRGRERSR------PIESIVEEVQRLRDQGYKQVTLLGQNVNSYRDMTTTLLEKVADAAPDIRFRFTSPHPKDFPM-RPNLCKQLHLPAQSGDDETLERME-RGYTRDLYLRLVDDIRHVLPSVSLTSDFIAGFGETEQAHQNTLSLIRAVRSFCFVFPYSMRGKTRAHHRLTDDVPEDVKARRHLDLTTVFREEALKLNQALIGSEQTV............................................ 487
28 -16.900[R] COG1313 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins  ali follow..  9  123..............................TVFFSGCNFRCVFCQNWDISQFRIGV----EYLPEYMAIKIEKAFQLGARNVNFVGGEPTPNLPFILETLRYVRVPIPIVWNSNMYMSEEAMKLLDGV-VDIYLGDFKYGNDRCAMKYS-KVPRYWEVVTRNFLLAKEHFRAEFLIRHLVMPNHLDCCTKPILRWIAEN-----MFQYRPEYKAI-EIARTLTLDEMREAEKI..................................................................... 325
29 -16.800[R] COG0641 Arylsulfatase regulator (Fe-S oxidoreductase)  ali follow..  9  1.........................MHITAKPTSYQCNLKCDYCFYLSKENIFQH---KGWMTEETLETFIERYISASGHDVYFT-GGEPDFFEKAIQYQNRYKKIHNALQTNGILLDDAWCLFLRENHF-LVGVSIDGPKEDRYRVTRSGKGSFDKVMAGIEQLKKHQVEFNTLTVINRINVKYPLEVYRTLKSI.......................................................................................................... 178
30 -16.300[R] COG0820 Predicted Fe-S-cluster redox enzyme  ali follow..  14  87.........RVGDQDVETVYIPEDDRATLCVSSQVGCALECKFCSTAQRNLRVSEIIGQVWRAAREIGLEKETGRRPITNVVMMGMGEPLLNMKNLIPALEIMLDDLGRVTVSTS----SGLEQMIGQIDVALAISLHAPNDKLRSEIMPDRWNIEAFLEVVRRYIAS--RGKVTVEYVLHVNDGTEHAHELAELLKGTPCKINLIPFNPYPGSPYKKPSNSRIDRFQKTLMQYEH.................................................................. 328
31 -15.100[E] COG1509 Lysine 2,3-aminomutase  ali follow..  10  119............................VLLLATDRCPVYCRFCTRSYGLDTQSVLKKKVSPFQSRWDTILAYLRVTVIADVVVSGGDC-LKPSRLLAIGMGLLSIPSIRRIRFATKGLAVLPMKITSDHKWTDALVNISDA-FHTHFNHPREITDYTIAAAELLFKRGIRMRNQSVLMAGVNDDPEVMKQLVKKLSDLHIQPYVYTCDLVDGIEHMRCSVRLACQIEK......................................................................... 332
32 -15.100[L] COG1533 DNA repair photolyase  ali follow..  10  41.PFKTEVQVEKPRTIITRNESPDISFDRSINPYRG-CEHGCVYCFARPGLSPGLDFETKLFAKPDAARLLDKELSKEGYQPRTIAIGTNTDPYQPIEEILEVLEARGHPVGIALVTRDIDILSRMAERGLAKVALSVTTLDRMLARTMEPRASTPTKRLEAIRQLSDAGIPTSVMVAPII--GLTDQEMERILDSAYAAGAREAGYVVLRLPLE-LLRHYPDRYRHVMSLIR...................................................................... 292
33 -12.000[O] COG0602 Organic radical activating enzymes  ali follow..  8  1MQYPINEMFQTLQG---EGYFTGVPAIFIRL---QGCPVGCAWCDTKHTWDKLSKTKESDKWGAASSEDLLAVINRQGYTARHVVITGGEPCIHDLMPLTDLLEKSGFSCQIETSGTHEVRCTPNTWVTVSPKVNMRGGYDVLSQALERANEIKHVRDIEALDELLATLSDDKPRVIALQPISQKEDATRLCIETCIARNWRL................................................................................................... 212
FFAS is supported by the NIH grant R01-GM087218-01
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Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.