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Query: [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSAVPEQVLGATRASDVDPQETKEWLEALQGVIGAEGPDRAAFLLDKQLEYARINGVTSPLHAETPYINTIPVENQERIPGDQEIEHRIRSFTRWNAMAMVLRANKDTNVGGHISSFASAATLYDVGYNHFWHAPSDKHGGDMVFVQGHSAPGVYSRAFLLGRLSEDQLDSFRQEVDGKGISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFTKYLASRSLIQNFENRKVWAFLGDGETDEPESLGAIGMAGREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIKVIWGSRWDQLLARDTKGLLMSRMMECVDGEYQTFKSKSGAYVREFFFNTPELKAMVADWSDDDIWALNRGGHDPHKIFAAFKSATEHKGQPTVILAKTIKGYGMGEAGEAMNIAHQQKKMPVDAIRKLRDRFNIPVADDQLEHVPYVKFEEGSKELEYMRRARMDLGGYLPARRQKADALQVPALAAFDALLKATGEGREVSTTMAFVRILNILLKDKNVGKHVVPIVPDESRTFGMEGLFRQVGIWNQEGQKYVPQDHDQLMFYKESQTGQVLQEGINEAGAMCDWIAAATSYSTHGVAMIPFYIYYSMFGIQRIGDLCWAAGDMRSRGFLLGGTAGRTTLNGEGLQHEDGHSHVYHAAIPNCISYDPTFQYELAVVMQDGLRRMYVEQEDVYYYLTVMNENYEHPEMPAGAEADIIKGMYLFKKGVENSNAPRVQLLGSGTIFREVIAAAELLKKDWGVESDLWGCPSFTELAREGNAAARWNLLHPTDAPRESHVEKMLKGVRGPVIASTDYVRTFAEQIRAFVPRRYVVLGTDGFGRSDTREKLRHFFEVDRYWVTVASLKALADEGVLPREKVAEALKKYNLDPNKPNPMTVLast
1 -244.000[C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component  ali  100  1MSAVPEQVLGATRASDVDPQETKEWLEALQGVIGAEGPDRAAFLLDKQLEYARINGVTSPLHAETPYINTIPVENQERIPGDQEIEHRIRSFTRWNAMAMVLRANKDTNVGGHISSFASAATLYDVGYNHFWHAPSDKHGGDMVFVQGHSAPGVYSRAFLLGRLSEDQLDSFRQEVDGKGISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFTKYLASRSLIQNFENRKVWAFLGDGETDEPESLGAIGMAGREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIKVIWGSRWDQLLARDTKGLLMSRMMECVDGEYQTFKSKSGAYVREFFFNTPELKAMVADWSDDDIWALNRGGHDPHKIFAAFKSATEHKGQPTVILAKTIKGYGMGEAGEAMNIAHQQKKMPVDAIRKLRDRFNIPVADDQLEHVPYVKFEEGSKELEYMRRARMDLGGYLPARRQKADALQVPALAAFDALLKATGEGREVSTTMAFVRILNILLKDKNVGKHVVPIVPDESRTFGMEGLFRQVGIWNQEGQKYVPQDHDQLMFYKESQTGQVLQEGINEAGAMCDWIAAATSYSTHGVAMIPFYIYYSMFGIQRIGDLCWAAGDMRSRGFLLGGTAGRTTLNGEGLQHEDGHSHVYHAAIPNCISYDPTFQYELAVVMQDGLRRMYVEQEDVYYYLTVMNENYEHPEMPAGAEADIIKGMYLFKKGVENSNAPRVQLLGSGTIFREVIAAAELLKKDWGVESDLWGCPSFTELAREGNAAARWNLLHPTDAPRESHVEKMLKGVRGPVIASTDYVRTFAEQIRAFVPRRYVVLGTDGFGRSDTREKLRHFFEVDRYWVTVASLKALADEGVLPREKVAEALKKYNLDPNKPNPMTV 896
2 -140.000[G] KOG0523 Transketolase  ali follow..  19  1MASTSSLALSQALLARAISHHGSDQRGSLPAFSGKSTGSRASASSRRRIAQSMTKNRSLRPLVRAAAVETVEPTT------DSSIVDKSVNSIRFLAIDAV-EKAKSGHPGLPMGCAPMAHILYDEVMRYNPKNPYWFNRDRFVLSAGHGCMLLYALLHLAGYVQEEDLKQFRQWGSK--TPGHPENF-ETPGIEVTTGPLGQGIANAVGLALAEKHLAARFNKPDAEDHYTYAILGDGCQMEGISNEACSLAGHWGLGKLIAFYDDNHISIDGDT--EIAFTENVDQRFEALGWHVIWVKNG------------------------------------------------------------------NTGYDEIRAAIKEAKTVTDKPTLIKVTTTIGYGSPNK--ANSYSVHGAALGEKEVEATRNNLGWPYEPFQVPDDVKSCLATLESDWSAKFAAYEKKYPEEASELKSIITGELPAGWE-KALPTYTPESPGDATRNLSQQCLNALAKV---VPGFLGGSADLASSNMTL--------------------KAFGDFQKATPEERNLRFGVREHGMGAICNGIAL----HSPGLIPYCATFFVFTDYMRGA--MRISALSEAGVIYVMTHDSIGLGEDGPTHQPIEHIASFRAMPNTLMFRPADGNETAGAYKIAVTKRKTP-----SILALSRQK--LPHLPGTSIEGVEKGGYTISDD-SSGNKPDVILIGTGSELEIAAQAAEVLRKD-GKTVRVVSFVCWELFDEQSDE----------------YKESVLPSDVSARVSIEAASTF---GWGKIVGGKGKSIGINSFGASAPAPLLYKEFGITVEAVVDAAKSFF.............................. 754
3 -134.000[G] COG0021 Transketolase  ali follow..  19  1.....................................................................................MSQLANAIRFLSADAV-QKANSGHPGAPMGMAEMAETLWTKFLNHNPANPKFYNRDRFVLSNGHASMLLYSLLHLTGYLSIEDLKNFRQLHSK--TPGHPEYG-YTDGVETTTGPLGQGIANAVGMALAEKILAAEFNKDGLNDHYTYVFMGDGCLMEGVSHEACSLAGTLGLGKLIVLYDDNNISIDGKV--DGWFTENIPQRFESYGWHVVPNVNG-------------------------------------------------------------------HDTAAIQAAIEAARAETGKPSIICCKTLIGKGSANK--EGSHKTHGAPLGADEIEATRKHLGWTYPAFEIPQEIYDAWAKLEAEWNELFAQYQTKYPAEAAEFVRRMDKKLPDEYVQAALKEVCAKAETIATRKASQNSIEILAKE---LPELVGGSADLTPSNLT--------------------DWSNSVSVTRDKGGNYIHYGVREFGMGAIMNGLVLHGG-----VKPFGATFLMFSEYERNA--LRMAALMKINPVFVFTHDSIGLGEDGPTHQPIEQTATLRLIPNMDVWRPCDTAESLVAWAEAVKAADHP-----SCLIFSRQNLKFQARSEQQLNDIKRGGYVISEA---QGNAQAVIIATGSEVELALEAQKALAAQ-NIAVHVVSMPSTNVFDRQDTAYQAA-----------------VLPESLPRIAVEAGHA---DGWYKYVGLNGAVVGINRFGESAPADLLFKAFGFTVDNVVDTVKSVL.............................. 659
4 -96.900[G] COG3957 Phosphoketolase  ali follow..  12  2.....................................................................STVPAKGPLTPQQLSLINRYWRAANYLSVGQI-YLMKNPLLREPLQPEHIKPRLLGHYAHLNRIIQQRNANVIYICGPGHGGPGMVANTYLEGTYSEIYMERLRQFSFPGGIPSHAAP--ETPGSIHEGGELGYALVHAYGAAFDNP------------DLVVACVVGDGEAETGALWHSNKFLNPARDGAVLPILHLNGYKIANPTVLARLSDDDLDNLFRGYGYEPFFV-EGSEPADMHQKMAA-------------------------------------------------TLDTIFQRIQDIKKNADVHSPERPRWPMIILRSPKGWTGPKTVDENYWRAHQVPVANCRENDAHRKILEDWMKSYDPSDLFDEKGALKPELRALAPKGEARIGANPHANGGLLRKELHMPDFRQAVNVTEPGAIEAQSTKILGDFLRDVMKLNETEKNFRIFGPDETASNRLGSVLEATNRVWMA---------ETLDMDDHLAADGRVMEVLSEHLCQGWLEGYLLSGR------HGFFSCYEAFIHIKWLQVARELEWRKPSSLNYLLTSHVWRQDHNGFSHQDPGDLVANKSADIARVYFPPDANTLLWVGDHCLKTWNR-----VNVIVAGKQPEPQWLTMAEAEKHCEAGLGIWEAGTEDGLEPDIVMACAGDVPMETLAAVDLLRQS-LPHLRIRVVNVVDLMVLQSPHQHPHGISDEEFDR--------MFTTNRPVIFAYHGYPYLIHRLKRTNHSNFHVRGFIEQGTTTTPFDMTVLNELDRFHLAMEAVERLPLGESVAKPLIDNFIRQHGEDMPEIRDWK. 787
5 -78.100[HI] COG1154 Deoxyxylulose-5-phosphate synthase  ali follow..  14  24.................................................................................PKESLPKLCDELRRYLLDSV--SRSSGHFASGLGTVELTVALHYVY---------NTPFDQLIWDVGHQAYPHKILTGRRDKIG-----TIRQKGG---LHPFPWRG-ESEYDVLSVGHSSTSISAGIGIAVAAEK--------EGKDRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILNDNEMSISENV----GALNNHLAQLLSGKLYSSLRE-GGKKVFSGVRTEEHIKGMVVPGTLFEELGFNYIGP-------------------------------VDGHDVMGLISTLKNMRDLKG-PQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSS-------------------------------------------------------------------CLPKSSGGLPGYSKIFGDWLCETAAKD---SKLMAITPAMREGSGMVEF-------------------------SRKFPDRYFDVAIAEQHAVTFAAGLAIGG------YKPVVAIYSTFLQRAYDQVIHDVA-IQKLPVMFAIDRAGI-VGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGP-----TAVRYPRGNAQGVALTPLEK-------LPIGKGLVKRHGEKLAILNFGTLMPEAAKVAE------ALNATLVDMRFVKPLDDTLILEMAAQH-DALVTLEENAIMGGAGSGVNEVLMAHR------------KPVPVLNIGLDFFIPQGTQEEARAELGLDAAGIEAKIKAWLA............................. 620
6 -73.700[G] COG3959 Transketolase, N-terminal subunit  ali follow..  23  6................................................................VPMEKGGGSDGTPISIEELDKLRQVAEKARRNVIKML-FYDQTIHVGSSLSSIEILTTLIFKHIRT---DSSLVNKDWLILSKGHAAPALYAVLAEKGYIKEEELWRIQDITGL--LQGHPET--FIPGVDMSTGSLGQGLSFGIGVATGIKM--------ANGTGRVYVIMGDGEQDEGEIWEAMTHAVVRNLDNLIAFIEMNNFQLDGST-DEIKPKNFLPKVWEAVGWKVLNC--------------------------------------------------------------------DGHDFISITNAVNEAYK-ASKPVVIFAKTVRGKGFPPI--ENTHKQRSSPDDARKYLL...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 279
7 -49.300[G] COG3958 Transketolase, C-terminal subunit  ali follow..  14  3.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KLAPAGLKDDIEMRKVYAGFIAGQIEAG---SPIIALEADLMSSMAMDSV-------------------------ARDYPQHVINCGIMEANVIGTAAGLALTG------RKPFVHTFTAFASRRCFDQLFMALDYQRNNVKVIASDAGVTACHNGGTHMSFEDMGIVRGLAHSVVLEVTDAVMFADILRQLMDL------DGFYWLRTIRKQ--ARSIYAPGSTFTIGKGNVLRE------GDDITLIANGIMVAEALEAARQLEQE-GVSAAVIDMFTLKPIDRMLVKNYAEKT-RRIVTCENHSIHNGLGSAVAEVLVEN-------------CPVPMRRVGVERYGQVGTQDFLQKEYGLTAEAIVEAAKSLL.............................. 317
8 -19.700[C] KOG0524 Pyruvate dehydrogenase E1, beta subunit  ali follow..  14  33..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NGVKEMTVRDALNSAMEEEMKRD---DRVFLIGEEVAQYNGSRGLLDKFG------------------------PKRVIDTPITEMGFTGLATGAAFAG------LRPICEFTFNFSMQAIDHIVNSAARTLYMS-IVFRGPNGPAAAV-AAQHSQ-HFAPWYGSIPGLKVVSPYSAEDARGLLKAAIR----DPNPVVVL-----ENEILYGKTFPISKEALSEDFVFGLAKVERPGKDITIVGESISVVTALEAADKLKADYGVEAEVINLRSIRPLDINTIAASVKKT-NRIVTVDQAYSQHGIGSEIAAQIMESDA---------DYLDAPVERVSMADVPMP--SHPVEAASVPNADVVVAAAKKCLYIK........................... 366
9 -18.700[C] COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit  ali follow..  12  2...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PDIPEGTEMVMTTVREALRDAMAEEMRADEKVFVMGEEVAEYQGTQGLLQEFG------------------------ERRVIDTPITEHGFAGIGVGAAMTG------LKPIVEFTFNFAMQAIDQIVNSAAKTLYMS-MVFRGPSGAAARV-GAQHSQ-CYAAWYSHIPGLKVVMPYTAADAKGLLKAAIR----DPNPVIFLENEILYGQSFEVPKLDDFVLPIGKARIHRK------GKDATIVSFGIGMTYAIKAVAELEKL-GIDVELIDLRTIRPMDLPTVIESVKKT-GRLVTVEEGFPQSSVGDFIANQVMRAAF---------DYLDAPILTIAGKDVPMP--AANLEKLALPNVDEVVQAVKTVCYK............................ 335
10 -14.400[C] COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit  ali follow..  12  21............................................................................RTMLLARKIDERMWLLNRSGKIPFVI--SCQGQEAAQVGAAFAL------------------DREMDYVLPYYRD---MGVVLAFGMTAKDLMMSGFAKAADPNSGGRQHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKK--------DIAAFVTFGEGSSNQGDFHEGANFAAVHKLP-VIFMCENNKYAISVPYDKQVA-CENISDRAIGYGMPGVTV--------------------------------------------------------------------NGNDPLEVYQAVKEARERGEGPTLIETISYRLTPHSSDDDDSSYR------GREEVEEAKKS.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 273
11 -14.400[C] KOG1182 Branched chain alpha-keto acid dehydrogenase complex, alpha subunit  ali follow..  16  105..............................................PCYRVLDEDGRIIPDSDFIPVSEKLAVRMYEQMATLQVMDHIFYEAQRQGRISFYL--TSVGEEAINIASAAAL------------------SPDDVVLPQYRE----PGVLLWRGFTLEEFANQCNKADYGKGRQMPIHYGSNRLNYFTISSPIATQLPQAAGVGYSLKMDKK--------NACTVTFIGDGGTSEGDFHAGLNFAAVMEAP-VVFICRNNGWAISTHISEQFR-SDGIVVKGQAYGIRSIRV--------------------------------------------------------------------DGNDALAVYSAVRSARETEQRPVLIEMMTYRVGHHSTSDDSTKYRAADEKMSRNPVNRFRKWV-----------------DNGWWSEEDESKLRSNARKQLLQAIQAAEKWEKQPLTELFNDVYDVKPKNLEEQELGLKELVKKQPQDYPPGFHV..................................................................................................................................................................................................................................................................................................................................................................................... 472
12 -12.600[C] KOG0225 Pyruvate dehydrogenase E1, alpha subunit  ali follow..  14  49...............................................................GPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGI---------------NPTDHLITAYRA----HGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGK--------DEVCLTLYGDGAANQGQIFEAYNMAALWKLP-CIFICENNRYGMGTSVERAAASTDYYK---RGDFIPGLRV--------------------------------------------------------------------DGMDILCVREATRFAAASGKGPILMELQTYRYHGHSMSDPGVSYR------TREEIQEVRSK.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 313
13 -10.000[C] COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes  ali follow..  10  147...............GKETMKLADLYAALKQTY---GSVGAEYMHITNTEEKR-------------IQQRIESVVGKPTFSDAEKRRFLSELTAAEGLERYLGAKFPGAKRFSLEGGDSLVTMLKEMIRHAGKN----GTREVVLGMAHRG--LNVLINVLGKKPEDLFDEFAGKHKEHLGTGDVKYHQGFSSVETEGGLVHLALAFIVSPVVIGSVRARRDRLDEARSNMVLPITGDAAITQGVVQETLNMSQGYEVGGTVRIVINNQIGFTTSNPLDARSTQYCTDIAKMVQAPIFHV-NADDPEAVA----------------------FVTRLALDFRNTFKRDVMI----------DLVCYRRHGHN-------------EADEPSATVMYQKIKKHPTPRKIYADKLIEQNIASLEDATEMVNLYRDALDHGDCVVEEWRPMNLPSKVEMKRLQELARRISSAPEAIEMQSRVAKIYSDRALMASGEKPFDWGGAETLAYATLVDE-------GIPIRLSGEDAGRGT----FFHRHAVIHNQKNGSVYVPLSNIHSGQGDF--QVWDSVLSEEAVLAFEYGYATAEAQFGDFANGAQVVIDQFISSGEQK-------GRMCGLVMLLPH---GYEGQGPEHSSLERYLQLCAEQNMQVCIPSTPAQVYHMIRRQALRGMRRPLIVMSPKSLLRHPLATSSL-----DELANGSFIGEIDELDPKGIKRVVMCSGKVYYDLLEQRRKNGQTDVAIVRIEQLYPFPHQAVQSVLEQYAHVHDFVWCQEEPLNQGA---------------YCSQHNFREVIPFGASLRYAGRPASASPAVGYLSVHQKQQQALVNDALNV............................... 934
14 -9.240[C] COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits  ali follow..  9  1............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MLNDVVRDAEGEKVFLLGNEAIARGA-IEAGIDVFAAYPGTPSSEIADTLSDACRLLRGKMDFYMEYSANEKVAFEVAVGASLAGKR---------------AMATMKHVGVNVAADPLFSFAYVGARGGVLVTADDPSSQNEQDNRWYGKAAKLPVVEPSSVQEAKDYAKLCFDLSEKFGLPMILRSYTRLSHASGVVELGKIPEKEFSRVEWERHPETDEGDGDVGIIACGLSYAYTKEALENL----NLNLPVLKLSSMHPLPERLIEN--------------------FVSQMKKVIVVEEVDPFVELHVRAMGLAEVYGKMNGYMPMNY---------EYNVGRVETGIAKALGIKPSRDYEGIVAESQKLAAKAPPRPP... 374
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Jaroszewski L, Li W, Godzik A. A segment alignment approach to protein comparison. Bioinformatics. 2003 Apr 12;19(6):742-9.