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Query: [R] COG3054 Predicted transcriptional regulator, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTLRKILAMSCLLLPIMACAHNLEVNQRVPPVGIADRGELTLNKDEFSYKNWNSAQLAGKVRVLLHIAGRTSAKEKNATLIEAIKSAKLPHDRYQTTTIVNTDDAIPGSGMFVRSSIESNKKLYPWSQFIVDSNGVARNAWQLKEEGSAVIVLDKDGRVQWVKDGALTQQEVQQVVDLLHKLLSKLast
1 -83.800[R] COG3054 Predicted transcriptional regulator  ali  100  1MTLRKILAMSCLLLPIMACAHNLEVNQRVPPVGIADRGELTLNKDEFSYKNWNSAQLAGKVRVLLHIAGRTSAKEKNATLIEAIKSAKLPHDRYQTTTIVNTDDAIPGSGMFVRSSIESNKKLYPWSQFIVDSNGVARNAWQLKEEGSAVIVLDKDGRVQWVKDGALTQQEVQQVVDLLHKLLSK 185
2 -26.800[O] COG1225 Peroxiredoxin  ali follow..  11  2.....................PVTLDQPLPDFSAPAT----------SGLTFSLAGQRGKVVVLYFYPKDNTPGCTTEAMNFRDQYDAFEAADAVVFGISRDSLKSH------ENFKAKLELPFE---LLSDADEAVCALFDTIKMKKSTFLIDRKGVLRQEWRGVKVPNHVDEVLGAVRAL... 154
3 -22.100[O] COG0450 Peroxiredoxin  ali follow..  12  2......................SLINTEIKPFTAQAYKD--------KFVTVSEADVKGKWSVFFFYPADFTFVCPTELEDLADNYDVFTRLGVEIYAVST--DTHFSHKAWHDSSPAIGKIKYT---MVGDPSGQVTNNFEIMRPGVGTFLVDPQGVIQFMEVTAEGGRNAIELLRKIKAA... 155
4 -21.900[O] COG2077 Peroxiredoxin  ali follow..  14  10..............EIEVSGVFPQVGDVVTDFTTVSA----------KLEDTTLANFAGKRKILNIFPSDTGICATS---VRKFNEQAAKLANTAVLCLST--DLPFAQARFCGAEGLENV-----FTVSTFRNKDVHKQLGVDIVARAVIVLDENNRVLHSELVP-QEPNYDAALAVL...... 165
5 -21.300[O] KOG4614 Inner membrane protein required for assembly of the F0 sector of ATP synthase  ali follow..  11  117.......................................PHLIGTAMDGTKQQNIELRGKTSIVRLFSTASGDKLSSSGIVDDNKKTDLNDSNVQIIEVNLVENAVKSALVKTLARWANRVPSWRQPFYFE-WPFSVREELFCNNVSGYVFLVDQQLKIRWAACGEATPSEKEALWKFAKRL... 279
6 -21.000[O] KOG0541 Alkyl hydroperoxide reductase/peroxiredoxin  ali follow..  16  2....................APITVGDVVPDGTISFFDE------NDQLQTVSVHSIAGKKVILFGVGAFTPTCSMSHVPGFIGKAEELKSKGIDEIICFSVNDP------FVMKAWGKTYPENKHVKFVADGSGEYTHLLGLELDLKDALLLD-NLKVTVANVESGGEFTVSSAEDILKAL... 162
7 -20.600[R] KOG2501 Thioredoxin, nucleoredoxin and related proteins  ali follow..  8  2.............................................STNVMQVLVSKLVGKTIGLYFGAHWCPPFRSFTSQLVDVYNELATTDKFEVILISTDRD---------SREFNINMTNMPWLAIPYEDRQDLCRIFNV-KLIPALVIIGPEEKTVTTNAREMVSLYGSRSFPFTESRIVE 135
8 -20.400[O] KOG0855 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes  ali follow..  8  58.................SDVNELEIGDPIPDLSLLNE----------DNDSISLKKITENVVFFVYPRASTPGCTRQACGFRDNYQELKKYAAVFGLSADSVTS---------KKFQSKQNLPYH---LLSDPKREFIGLLGAKKTP-SHFIFV-DGKLKFKRVKISPNDAKKEVLEVAEKFKEE 215
9 -20.000[O] KOG0852 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes  ali follow..  10  45.................LQYTKAVISKPAPQFEGTAVVNKEI-------VKLSLSQYLGKYVVLLFYPLDFTFVCPTEIIAFSDRIAEFKKIKTEVIGVSV--DSHFTHLAWINTPRKEGGLGDVKIPLLSDLTHKISKDYGVYLESSGLFIIDQTGVLRQITMNDLPGRSVDETIRLVQAF... 206
10 -19.600[O] COG2143 Thioredoxin-related protein  ali follow..  9  7VSKKFLSVLLLISLFLSACKSNNKDKLDENLLSSGSQSSKELNDERDNFSDNKSISPNDKYMLLVFGRNGCSYCERKKDLKNVKELRDYIKEHFSAYYVNISYSKEHDFKVGDKNNEKEIKMS----------TEELAQIYAV-QSTPTIVLSDKTGKTIYELPGYMPSTQFLAVLEFIGD.... 189
11 -18.200[O] COG0678 Peroxiredoxin  ali follow..  14  1......................MTVKKKVPFVTFRVRDDSIEGPNPYRWEDKTSDDFRGKRIILFSLGAFTPTCSTLQLPDFEMLYDEFEKEGIDAIYCVSVNDAFVMNA--------GKALGLQKVQLIPDGSGEFTRKMGMLVAKDNAAVIN-NGVVEQWFEDPYGVSSPQNVLETLRAA... 176
12 -17.200[O] KOG1651 Glutathione peroxidase  ali follow..  15  14........................................QFTVKDSSGKDLNMSIYQGKVLLIVNVASKCGFTETNYTQLTELYRKYKDQDEILAFPCNQFLYQEPGTSQEAHEFACERQNAAPIYKFLKASKPTFLGKWNFTK-----FLVGKDGLVIDRYGTMVTPLSIEV---SVLYISKV 169
13 -16.700[O] KOG0910 Thioredoxin-like protein  ali follow..  16  81.............................................EIGESEFSSTVLESAPVLVEFVATWCGPCKLIYPAMEALSQEYGDKLTIVKIDH--------------------------------DANPKLIAEFKV-YGLPHFILF-KDGKEV-RREGAITKAKLKEY---IDGLLNS 186
14 -16.100[AD] KOG3414 Component of the U4/U6.U5 snRNP/mitosis protein DIM1  ali follow..  6  22.........................................................EERLVVIRFGHDWDETCMQMDEVLASVAETIKNFAVIYLVDI--------------------------------TEVPDFNTMYELYD-PSTVMFF-FRNKHIMIDLGTGNNNKINWALKDKQEFID. 114
15 -14.500[O] COG0386 Glutathione peroxidase  ali follow..  11  5........................................DFQMKDAEGNAVDLSGYRGKVLLIVNTATRCGLTPQYEALQKLYAQYTAEGLEILDFPCNQFREQAPESSGEIAQVCMMKANTAPLYAYLKSVKPQDKGKWNFTK-----FLVNRDGEVVERFAPSVTPEEIEADIRAL...... 176
16 -14.400[O] COG3118 Thioredoxin domain-containing protein  ali follow..  10  2...................................SDTPYIFDVTGANFEQLVIENSFHKPVLVDFWADWCAPCKALMPLLAQIAESYQGELLLAKVNC--------------------------------DVEQDIVMRFGI-RSLPTVVLF-KDGQPVDGFAGAQPESQIRALLEPHVKAPAL 117
17 -13.500[S] COG4312 Uncharacterized protein conserved in bacteria  ali follow..  10  32..............AITAERLALPWVKVDTRYVFDTA----------SGKKTLADLFDGRSQLMIYHAAGCPGCSLVADHLGGTLAH-LNHHDVTLIAVSR------APLPEIEAYRQRMGWQFP---WASSFGTTFNHDFRVSFTGLSAFYKDEAGNVYHTYSTYARGLEDLIGTFLILDRAPK 215
18 -13.500[O] KOG0907 Thioredoxin  ali follow..  11  206.........................................................GGKLIVLDVGLKHCGPCVKVYPTVLKLSRSMSETVVFARMNGDEN-----------------------------DSCMEFLKDMNV-IEVPTFLFI-RDGEIRGRYVGSGKGELIGEILRYSGVRVT. 301
19 -12.500[S] KOG4498 Uncharacterized conserved protein  ali follow..  11  62...................GIGKGTADSLDTVKVLDL----------RGNEIPISDLDRKAVVAFARHFGCVLCRKRAAYLAEKKDV-MDASGVALVLIGP------GSIDQANTFVEQTKFKGE---VYADPNHASYEALEFVSGQGGILVAGPGKDISYIRK..................... 229
20 -12.400[O] KOG0191 Thioredoxin/protein disulfide isomerase  ali follow..  14  1MRLPLLSFVIFALFALVFASGVVE----------------LQSLNELENTIRA----SKKGALIEFYATWCGHCKSLAPVYEELGALFEDHNDVLIGKI--------------------------------DTHSDVADKYHI-TGFPTLIWFPPDGSEPVQYSNARDVDSLTQFVS........ 126
21 -12.200[S] KOG2640 Thioredoxin  ali follow..  5  185....................................................FLNPNGSDCTLVLFYTPWCRFSASLAPHFNSLPRA------FPALHFLALD---------------------------ASQHSSLSTRFGT-VAVPNILLFQGAKPMARFNHTDRTLETLKIFIF........ 275
22 -11.600[R] KOG4277 Uncharacterized conserved protein, contains thioredoxin domain  ali follow..  6  1MQKYFLLPLLSLSVLLFVYDTEATNPPT--------------AVLDLSDKFLDVKD--EGMWFVEFYAPWCAHCKRLHPVWDQVGHTLSDSNLPIRVGKLDC-----------------------------TRFPAVANKLSI-QGYPTILFFRNGHVIDY--RGGREKEALVSFAKR....... 130
23 -11.400[R] COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems  ali follow..  13  63.........................................FTLTDGEGKPFNLSDLKGKVVILSFGFTHCPDCPTELLTYSDTLKQ-LGGQAKDVKVVFVSIDPERDTPEIIGKYAKQFNPDFIGLTATGGQNPVIKQQYRVVDHSSGAYLIDKNGEVAIFSP---YGSEPETIAADVRTLL.. 217
24 -11.000[O] KOG0908 Thioredoxin-like protein  ali follow..  11  16.....................................................LAQAGIQLVVVDFTASWCGPCKRIAPIFETFPTKY---PKAIFLKV-------------------------------VDKCQDTAAGQGV-SAMPTFIFY-RNRTKIDRVQG----ADVNGLEAKIQEHIGT 108
25 -9.830[OC] KOG1672 ATP binding protein  ali follow..  8  70.............................................EVSEGDFLGEVTRSEKVICHFYHKEFYRCKIMDKHLKTLAPRHVDTK-------------------FIK--------------VDAENAPFFVTKLAI-KTLPCVVLF-SKGVAMDRLVGFQDLGTKDDFTNKLENVLLK 175
26 -9.790[OC] COG0526 Thiol-disulfide isomerase and thioredoxins  ali follow..  15  1MKISNLLAAFLAFSGGFFCASAEVP--------------------KVNKEGLNELITADKVLMVKFYAPWCGHCKALAPEYESAADELEKDG----ISLVEVD---------------------------CTEEGDLCSEYSI-RGYPTLNVF-KNGKQISQYSGPRKHDALVKYMR........ 124
27 -9.590[S] COG4929 Uncharacterized membrane-anchored protein  ali follow..  10  1MLKRKWLSIAVIIVALIMVNISIYQKQHL----LAKGDIIILELAPVDPRSL----MQGDYMALSYALVAPFNEQFNAEQEKCREEPELDDRQRATAARIDQGEPLADNQHYLQYRFKGRSIQIGTDAYFFQEG----HAEDYVNARYGEFRVAKDGSAL......................... 161
28 -9.370[O] KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit)  ali follow..  10  448.........................................................ESKDVLLEIYAPWCGHCQSFEPIYNKLGKYLKGIDSLVVAKM--------------------------------DGTSNEHPRAKA-DGFPTILFF-PGGNKSFDPIAVDVDRTVVELYKFLKKHAS. 540
29 -9.260[OC] COG4232 Thiol:disulfide interchange protein  ali follow..  7  411.GWMRIVQIILLAAALVSVRPLQDWAFGATHTAQTQTHLNFTQIKTVDELNQALVEAKGKPVMLDLYADWCVACKEFEKYTFSDPQVQKALADTVLLQANVTAND--------------------------AQDVALLKHLNVL-GLPTILFFDGQGQEHARVTGFMDAETFSAHLRDRQ..... 564
FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 9 3 8   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;