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Query: [P] COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLAGVDGVGGIPFDNYPFAYMVSNLALAIILLDGGMRTQASSFRVALGPALSLATLGVLITSGLTGMMAAWLFNLDLIEGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGSNDPMAVFLTITLIAMIQHHESNISWMFIVDILQQFGLGIVIGLGGGYLLLQMINRIALPAGLYPLLALSGGILIFSLTTALEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVNPSDLLPIAIPALILSAWMIFFARPLSVFAGLLPFRGFNLRERVFISWVGLRGAVPIILAVFPMMAGLENARLFFNVAFFVVLVSLLLQGTSLSWAAKKAKVVVPPVGRPVSRVGLDIHPENPWEQFVYQLSADKWCVGAALRDLHMPKETRIAALFRDNQLLHPTGSTRLREGDVLCVIGRERDLPALGKLFSQSPPVALDQRFFGDFILEASAKYADVALIYGLEDGREYRDKQQTLGEIVQQLLGAAPVVGDQVEFAGMIWTVAEKEDNEVLKIGVRVAEEEAESLast
1 -118.000[P] COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain  ali  100  1MLAGVDGVGGIPFDNYPFAYMVSNLALAIILLDGGMRTQASSFRVALGPALSLATLGVLITSGLTGMMAAWLFNLDLIEGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGSNDPMAVFLTITLIAMIQHHESNISWMFIVDILQQFGLGIVIGLGGGYLLLQMINRIALPAGLYPLLALSGGILIFSLTTALEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVNPSDLLPIAIPALILSAWMIFFARPLSVFAGLLPFRGFNLRERVFISWVGLRGAVPIILAVFPMMAGLENARLFFNVAFFVVLVSLLLQGTSLSWAAKKAKVVVPPVGRPVSRVGLDIHPENPWEQFVYQLSADKWCVGAALRDLHMPKETRIAALFRDNQLLHPTGSTRLREGDVLCVIGRERDLPALGKLFSQSPPVALDQRFFGDFILEASAKYADVALIYGLEDGREYRDKQQTLGEIVQQLLGAAPVVGDQVEFAGMIWTVAEKEDNEVLKIGVRVAEEEAES 536
2 -64.400[P] COG0025 NhaP-type Na+/H+ and K+/H+ antiporters  ali follow..  18  35IVCG--AWPNFGLHVNFDPELFLVLFIPPLLFADGWKTPTREFIHHGREILGLALALVLVTIVGIGYLIYWMVGIPLVAAFALAAVLSPTDAVALSGIVGKGRIPKSIMGVLEGEALMNDASGLVALKFAIAVAMGTMSGATLEFLKVAIGGLLAGVAITWLYSKSLRIMSRWSGDDPATQIVLLLLLPFASYLVAEHLGVSGILAAVAAGMTISQSPLAMRLRADSVWSMLEFVFNGMVFILLGLQLDPTIQTWNLFADVAIIYGALLLLRFGWLWSMKKQFSDYTTRELWVASFAGVRGAITLAGVLSIPLSAFPSRYQLVFIATGVILLSVIIGVIALPPLLRGVVVADKSASR................................................................................................................................................................................... 432
3 -60.500[P] KOG1965 Sodium/hydrogen exchanger protein  ali follow..  19  82..................EDLFFIYLLPPIIFNAGFQVKKKQFFRNFMTIMLFGAIGTLISFVIISFGAKHLFDLTIADYLAIGAIFSATDSVCTLQVLNQDETP-LLYSLVFGEGVVNDATSVVLFNAIQRFDLTNINSIALEFAGNFFYLFILSTALGVAAGLLSAFVIKKGRHSTDREVALMMLLAYLSYMLAELFHLSSILTVFFCGIVMSNVTDKSKVTTKHTFAAMSFLAEIFIFLYVGMDALDISIGVSSILLGLILLGRAAFVFPLSFLSNLTKSSPDLKKQVTIWWAGLMRGAVSMALAYNQFTTKVLGNAIMITSTITVVLFSTVVFGLLTKPLVKHLQPSSKQSSTTALQITL............................................................................................................................................................................ 461
4 -56.900[P] KOG4505 Na+/H+ antiporter  ali follow..  15  49LIFGPYVAKLFVPTTDYITEELARVLLVVEVFAAGAELPRAYMLRHWRSMFVMLLPVMIFGWLVSTGFMYALIRLSFLESLAIAACITATDPVLASSIVGARRVPGHLRNMLLAESGCNDGMAIPFLYLAIYLIIEKPARHAGRVCIIILYECTFGCVLGAIIGVIARKMIKFSEMDRESFLVFYFVLALFCGGIGTIIGVDDLLVSFCAGAAFSWDSWFSKKTESHVSNVIDLLLNLSFFVYVGAIMPWPQFHMLSVWRLVVLAICILIARRIPAVLLFKSFDIINWREALFAGHFGPIGVGALYTCLVARAPNWYCIQVMWPVVCFLVLSSIIVHGSSIAFFMLGKRINTLALS.................................................................................................................................................................................... 446
5 -53.400[P] KOG1966 Sodium/hydrogen exchanger protein  ali follow..  16  56IIVG---LGYFLNQTTLSSHAFFLYLLPPIIFDAGYFMPNRALFKNFDSVLVFSVLGTLWNTFAIGGSLLIMMPFTTFEILVFSALISAVDPVAVIAIFEEIHVNEFLFINVFGEALFNDGVTVVLYQMFKSFALIGSENLYATGGLSFFVVALGGAAIGIIFAIATSLATKYTQGIKILAPVFIFLLPYMAYLTAEMVSLSSIIAIAVCGMLMKNITEAATNSVKYFTKMLAQCSETVIFMFLGLSTLTSEHH-IGATLVFCLIYRAIGIIVQCFILNKFRAKKFEVVDQFILSYGGLRGAIAYGLVVSIPAS-IQAKPMFITTTICVIYFTVFLQGITIRPLVNCLNVKKKEHREATMVESV............................................................................................................................................................................ 442
6 -46.000[P] KOG3826 Na+/H+ antiporter  ali follow..  14  101IIIKNITVFDQFFVPPFVETMIRKVALVMIIVRWGLATDIHFLYENALMPVTIGLVTAIGEIIAVTIASYFILNISFVMSIFCALILVTVSPAVTVPAMINFKSLKRIPENILAICCVDNLFCVILFMVLSSIIFTDAPIAT--TILLNAGSIVFGCIGGIVLGWILWRFPRSDAQFARITLLGTICIAVVIGTYLIKYSCSGFLAALITSAMSAMQKEKLECVESTYKYIWDSFALPLLFICLGMKFDCSTLTWEIVFLCIAVIAIGLLVRTILVMLVTL-SSHINFKEQIVVALSLLRATFQADLAPTLLLMATPFAALILKAAILSVLITAPIFDILLNLVGSKCLSQYNPQDAPAIEKNFDKTYMNGDHVDETIYAARPKTYSEYRSEAVIER........................................................................................................................................... 515
7 -21.800[P] KOG1650 Predicted K+/H+-antiporter  ali follow..  13  87IILGPSLFGQSS-SGKITLQTLSNLGFFIHLFLLGLRIDASIIRKAGSKAILIGTASYALPFSLGNLTVLFLKNT--HCISTVISLNAMTSFPVTTTVLAELNINSDLGRLATNCSIVCEAFSWIVALVFRMFLRDGTLASVWSFVWVTALILVIFFVCRPAIIWLTERRSISIDKAGEIPFFPIIMVLLTISLTSEVLGVHAAFGAFWLGVSLPDGPPLGTGLTTKLEMFATSLMLPCFISISGLQTNFFIIGESHVKIIEAVILITYGCKFLGTAAASA-YCNIQIGDAFSLALLCCQGVIEIYTCVMWK-----DEKVLNTECFNLLIITLLLVTGISRFLVVCL............................................................................................................................................................................................ 444
8 -21.300[P] COG0475 Kef-type K+ transport systems, membrane components  ali follow..  15  39AAIGDHGLKIVTYDQ---TKLLGELGVVFLLFAIGLELSFERLKAMRRYVFGLGSLQVLTTAIVIAGAMV-LIDGNSSAAIITGGGLALSSTALVMQVIDENRQSTQIGRISLAILLLQDLAVVPLLVIVPLLASNNKASLAVALGIAFLKAVTALLTIFIVGRVLLRPVFSFISSTSELPISMTLLIVLSAAWATETFGLSLALGAFVAGVLVAETEF--RLQAEESIYPFKSLFLGLFFMTVGMNIDALEMYEKISHILTLSIALICIKTLIITAFCIL--KGVAFYSGLLLSQGGEFGFILFSLGKDSGVLEESTADILLLVVTFTMALTPLL........................................................................................................................................................................................................ 375
9 -19.800[P] COG4651 Kef-type K+ transport system, predicted NAD-binding component  ali follow..  15  41VLAGPFTPGFVA--DTKLAPELAELGVILLMFGVGLHFSLKDLMAVKAIAIPGAIAQIAVATLLGMALSA-VLGWSLMTGIVFGLCLSTASTVVLLRALEERQIDSQRGQIAIGWLIVEDLVMVLTLVLLPAVAGMMEQGLAVDMGITIGKVIAFIAIMMLVGRRLVPWIMARSAATGSRELFTLSVLALIAFGAVELFDVSFALGAFFAGMVLNESELSHR--AAHDTLPLRDAFAVLFFVSVGMLFDPLILIQQPLAVLATLAIILFGKSLAAFFLVRLFGHSQRTALTIAASLAQI-GEFAFILAGLGMALNL--PQAGQNLVLAGAILSIMLNPVLFALLEKY............................................................................................................................................................................................. 390
10 -11.400[R] KOG4821 Predicted Na+-dependent cotransporter  ali follow..  9  54....................SIGYGCVAWIFLQSGLGMKSRSLMANMLN--RAHATILVLSFLITSSIVYGFCCAKIDDWVLIGLILTATCPTTVASVIMTTNAGGNSLLCV-CEVFIGNLLGAFITPALVQMFTNRAPFAYGRVMKQVGLSVFVPLFVGQVIQNCFPKGTAYYLLKKYHIKIGSYMLLLIMFSSFSTAFYQDAFTSVSHVCII-----------------FLCFFNLGIYIFFTGLSYLCARPWFILKLFPHEPIEGKSTRLYRYSYNIFRPFYYSKEDAICIMFCGPAKTAALGVSLITSQYGDKKEHLGKLLVPLVLVEQVMTANFFVSLFKRWIQKDAQADGS................................................................................................................................................................................... 396
11 -10.900[P] KOG2718 Na+-bile acid cotransporter  ali follow..  17  122.................VTPNWTIVGLTITMLGMGMTLTLDDLRGALSMPKELF-AGFLLQYSVMPLSAFFVSKLNLPPHYAAGLILVGCCPGGTASNI--------VTYIARG----NVALSVLMTAA--------------------------STVSAVIMTPLLTAKLAKQYITVDALGLLMSTLQV-------------VLLPVLAGAFLNQYFKKLVKFVSPVMPPIAVGT-VAILCGYAIGQNASAILMSGKQVVLASCLLHISGFLFGYLFSRI---GIDVASSRTISIVGMQNSLGVVLATQHFGNPLTAVPCAVSSVCHSILGSVLA........................................................................................................................................................................................................ 388
12 -10.200[O] KOG2292 Oligosaccharyltransferase, STT3 subunit  ali follow..  14  1...................................MNRTPKMLNSKVAGYSSLITFAILLIAWLAGFSSRLF------AVIRFESIIHEFDPWFNYRATAYMVQNGWYNFLNWFDERAWYPLGRIV---------GGTVYPGLMITSGGIHWLLHVLNIPVHIRDICVF----------LAPIFSGLTSISTYLLTKELWSAGLFAASFIAIVPGYISRSVAGSYDN--EGIAIFALQFTYFLWVRSVKTGSVFWSAAAALSYFYMV--------------------------SAWGGYVNLIPLHVFVLLIMGRYSPRLLTSYSTFYILGLLFSM........................................................................................................................................................................................................ 253
13 -10.000[R] COG0385 Predicted Na+-dependent transporter  ali follow..  11  33...................ALATKIAVGLLFFLHGARLSREAVIAGITHLHVTVLASTFVLFPILGLAAGWAIPGLSQSPFYTGILYLCVLPSTVQS-----------SIAFTSMARGNVSAAVVSASA--------------------------SNIFGMFLTPLLVGLLFAIKGGGGISMDALESILLQ------------LLAPFVLGQVLQPFIGNFVRRKARVLAVVDRGILMVVYLAFSEAIVEGLWRTVSWDDLGMMVGVNILLLAVVLLATWYGSKGFSRPDRITIMFCGSKKSLASGALMANAIFAGANVGNIVLPLMLFHQIQLMACAIIARKLAER............................................................................................................................................................................................. 316
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure. 2008 Nov 12;16(11):1659-67.