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Query: [S] COG3373 Uncharacterized protein conserved in archaea, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110
# Score Template Links and tools%idFirst MEPIVDGNILRSLNRSELRRKVLFYLLSIYPYRSYLSEISRAVKSDPSNVKGCLEGLGVRYTGEESLIGLGLVIVEQSKNGFKYFKINPEIVEEVRNMKNMFSDKKVYTVEIGLast
1 -60.100[S] COG3373 Uncharacterized protein conserved in archaea  ali  100  1MEPIVDGNILRSLNRSELRRKVLFYLLSIYPYRSYLSEISRAVKSDPSNVKGCLEGLGVRYTGEESLIGLGLVIVEQSKNGFKYFKINPEIVEEVRNMKNMFSDKKVYTVEIG 113
2 -21.600[K] COG4742 Predicted transcriptional regulator  ali follow..  15  1....MQSELIDVVFRSQKRRDLLLLLGE---EPRTMEDIKVLLDVSPTAILPQIK----------RLTDSNLVIQKNGS-----YELTDMGEQVFKKARA............. 78
3 -19.600[K] COG3432 Predicted transcriptional regulator  ali follow..  10  31.............RRKRGTMEIMFDILRNCEPKCGITRVIYGAGINYVVAQKYL----------DQLVKVGALNIKTENDR-KIYEITEKGKLLRTHIEEFIK.......... 109
4 -18.800[KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon  ali follow..  17  2...............KMKTLFLLIKLAKMGEITVTMRELSRELDVSPQTVLRWL----------EELKEQGYIHKRESRKG-TLVELTEKGINLLEKLYEEIST......... 83
5 -18.300[K] COG1846 Transcriptional regulators  ali follow..  9  41...............TPSEIHTIDAIGT--DEGLLMKELAERLGVTKGAVSQLV----------DRLEAKALVRRTPKVSRGIQVVLTDKGREAYRAHADMHAAFYEELQQ.. 126
6 -17.600[S] COG2469 Uncharacterized conserved protein  ali follow..  13  190.......KSKPKEKLSEVEEQILTMVYT----GVDSVSVESILGVTTEELNKMY----------DRLVNLGLARVVKIRKE---IELTPRGVALVSEIMKKAAR......... 269
7 -17.100[K] COG3355 Predicted transcriptional regulator  ali follow..  15  19........IAFMYGLSKSDVEVLHILLQNGK--MTTDDLSQKLNVTKASISKAL----------NNLLDKGLIQREPAEKEERKGRPNYIYWVEKERLYRKLEADLEKLAG.. 111
8 -17.100[K] COG5631 Predicted transcription regulator, contains HTH domain (MarR family)  ali follow..  15  82...............SPIEILILHSIRH-RDREKKLADICLALDIETHIATYAI----------RKLEKAGLLTTGKA-AKEKTVKITAKGAEACAHYAQIRERLLVDSTA.. 166
9 -17.000[K] COG1497 Predicted transcriptional regulator  ali follow..  18  2.......KALRKKG-ELTRFQILSEIAM-RQPYVRQKDIADKLGVTVQAVSENIK----------SLIAEGLVESG---SGRSHYKITRRGAEKIKEAAMDLRRYADEVLES. 91
10 -16.100[S] COG4344 Uncharacterized protein conserved in archaea  ali follow..  15  1MSEY--EKEIDELINDYDMLRVLKHFTIAHVD--YAKNITRYTEIPQMRVREYLK----------RLKDLGLLDYYTNTKHHTYYQINKKAEAVLKEITPK............ 103
11 -15.900[K] COG2345 Predicted transcriptional regulator  ali follow..  19  1MGDVVKGNDAHTGD-GDTRRKILLILLERAP--VIASDIAEQLQLSTVGVRRHL----------DNLVEENLAEAANPGRPAKTYRLTDKGRSIFGH................ 94
12 -15.600[K] COG1321 Mn-dependent transcriptional regulator  ali follow..  12  13...................LETILYLITKNQGPAKTKQIAEELNVSSPSVTEMIK----------KLHSMGFVEYKPYQG----VELTEKGAEEAVRIKRKHQVLETFLADV. 91
13 -15.400[K] COG5625 Predicted transcription regulator containing HTH domain  ali follow..  16  12.......DLLKAIGLKKNEIRIYRLLVEKR-RGMRIREIQRELGISERSVRTHVL----------NLYRRGLLKRELVQSGWLGYIYTPVSLEILQKIKEHLMK......... 98
14 -15.200[K] COG4190 Predicted transcriptional regulator  ali follow..  21  68...............TPRVLELIEAIRQEEP--ASINETARVVDRDVKNVHEELS----------RLAHLGIIFFEEDGQRKR.............................. 123
15 -15.100[K] COG4738 Predicted transcriptional regulator  ali follow..  12  27.......ELLRRLNINRPVALTLACLSKGDE--ISSQRIEMVSGLRQPEVSIAMR----------YLRENEWVDMREEGRPVKLYKLTVQMETIIDTIEENVIAESKTILQ.. 124
16 -14.700[K] COG1695 Predicted transcriptional regulators  ali follow..  15  2...............DRYAIKALVLLSK---KPRTLYQMSKEISTGVQVSHGTL------MPMIRKLLQERYIDFETRGRE-KVYHLTERGSRFVESLGKIEED......... 80
17 -14.300[K] COG1777 Predicted transcriptional regulators  ali follow..  23  1MIDDID-NFIAAIE-NSTRREIIRMLTQFER--SYALELSRSIGLSQQAILKQLE-----------LERANLVTSIGFVPS................................ 67
18 -13.600[S] COG4754 Uncharacterized conserved protein  ali follow..  14  16....................GLLYVMNNIFDGKTDLYQLEKEMEVDIDDLMPIV----------YTASRLGFVSAESGD-----IIVTEEGKEYIRASIKRRKEIIREAL... 90
19 -13.500[K] COG0640 Predicted transcriptional regulators  ali follow..  25  1...................................MNEITMQTQADQPKVSSNLA----------ILSEARLVDSIQMGRE-KIYRIAPEKEDMVDWLDS............. 55
20 -13.100[S] COG3398 Uncharacterized protein conserved in archaea  ali follow..  11  177.......KKVVSALQNATNQRIISEIQNGK--CNTNLALAREIGVSRATISWYVK----------NLKETGLIDETRSGRS-IIYSINPSYEPLIEK................ 253
21 -12.200[S] COG3388 Uncharacterized protein conserved in archaea  ali follow..  12  9.......EIINDMDTLKRHISVINVLLREQP--IGIIKLSQETGIPEHKIRYSL----------RILEQENIISPSREG-----AILTPDFIEHKEQIIADAEK......... 88
22 -11.900[K] COG1510 Predicted transcriptional regulators  ali follow..  10  22.......ENMHTFGMPSTVGRVLGIIY-MNRKPMTLSELSEATGMSKTRMSQVVR----------EMIDANIAEKEKGVRKDLYDVEQDYYQTFISLFAANWTKVVSKNKV.. 116
23 -11.900[K] COG4189 Predicted transcriptional regulator  ali follow..  23  15.......DVLKAAA-SLIRVQILKLLHEANG--LNVNEIAQRLALPQSTVSAGVA----------VLEEAGLLRTETRKARKGSQKI.......................... 81
24 -11.800[K] COG1414 Transcriptional regulator  ali follow..  13  1MREPTLETDDRYRAPALDKGLDILELLASVDGGLTQAEIAKHLDRSPNEFYRMLD----------RLVKRGYVTKLDGDRYSLTLKLFGLAQLHAPVRR.............. 89
25 -11.300[S] COG4860 Uncharacterized protein conserved in archaea  ali follow..  14  8VNDPGELVSIFHAADSEVKRKLLLDLST---GWITLPVIEQKYG---KEGRRALL-----------LDKIKMIETQGQNGPEKAYHTY......................... 82
26 -11.200[K] COG3888 Predicted transcriptional regulator  ali follow..  17  2................SLRDVLLRELKRARGLGIDQFQIEEMMGFSKSTVSEALK----------DLEEKGIIKRRTIGGKIKHVWLAEYYPYYDEKL-----------LRIG 77
27 -11.000[R] COG2005 N-terminal domain of molybdenum-binding protein  ali follow..  8  18...............DPRRISLLKHIALSG----SISQGAKDAGISYKSAWDAINDM-------NQLSEHMLVERATGGKGGGGAVLTRYGQRLIQLYDLLGQIQQKAFDV.. 102
28 -10.800[S] COG4519 Uncharacterized protein conserved in bacteria  ali follow..  8  1.........MELSPVFARRLYLALLVESL--ERPNVPKLIEKTGWPRRTIQDVIK----------AMPGIGIELNFVQDGRRHYYQLSDWGPFDSQWVTERKKD......... 86
29 -10.600[K] COG1733 Predicted transcriptional regulators  ali follow..  12  12........LSMAAEVLCTRWTMV-LMRELVAGSTRFNDLRRGVKMSPTLLSQRLK----------ELELAGIVERKPGEKGIFDYRLTEAGRDLRPVVEAMGF.......... 98
30 -9.900[K] COG1378 Predicted transcriptional regulators  ali follow..  16  21VTMDEIIEVLKRLGFRDYEARVYATLATRGE--ATASEIHRVSGVPRNKV----------YEVLRSLEDRGMIETIKSSP--AVFRAID--ESVLEEYKEQLVSAVDTAIR.. 116
31 -9.760[P] COG0735 Fe2+/Zn2+ uptake regulation proteins  ali follow..  15  1.........MVTPQLTKNQSLVMGALAHS-DGPMSAYTILDKLRDNGFRAPLQV------YRALDKLLEYGLVHRLESLNAFVACSCPHEHEH.................... 77
32 -9.470[K] COG3327 Phenylacetic acid-responsive transcriptional repressor  ali follow..  9  1MSKLDTFIQHAVNAVPVSGTSLISSLYGD--WLGSLAALLEGLGFGERFVRTAL----------FRLNKEGWLDVSRIGRR-SFYSLSDKGLRLTRRAESK............ 97
33 -9.460[J] COG4901 Ribosomal protein S25  ali follow..  12  63.................................ITPYEIASKYGIKMSVAFKVLR----------NLKERGDLVLVAKGHRTEIYVPAKRS...................... 110
34 -9.420[J] KOG2784 Phenylalanyl-tRNA synthetase, beta subunit  ali follow..  14  52LSSFEMTAETDVRSTENLPQQILDFLQESNE--FNSIQLAQQWNLDHQKVIGAIKSL---------LANEGVLTTKDVTE--KRLELTNEGVQFANE................ 135
35 -9.200[S] COG2512 Uncharacterized membrane-associated protein/domain  ali follow..  13  247...............SPELCEVLDIIRGHKGR-ITQKDLRSKLDYSEVKVSLML----------SELEKRGLIRKLRNGRE-NILVLVDEEH..................... 311
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 1 0 5   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;