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Query: [Q] COG3458 Acetyl esterase (deacetylase), from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAFFDLPLEELKKYRPERYEEKDFDEFWEETLAESEKFPLDPVFERMESHLKTVEAYDVTFSGYRGQRIKGWLLVPKLEEEKLPCVVQYIGYNGGRGFPHDWLFWPSMGYICFVMDTRGQGSGWLKGDTPDYPEGPVDPQYPGFMTRGILDPRTYYYRRVFTDAVRAVEAAASFPQVDQERIVIAGGSQGGGIALAVSALSKKAKALLCDVPFLCHFRRAVQLVDTHPYAEITNFLKTHRDKEEIVFRTLSYFDGVNFAARAKIPALFSVGLMDNICPPSTVFAAYNYYAGPKEIRIYPYNNHEGGGSFQAVEQVKFLKKLFEKGLast
1 -113.000[Q] COG3458 Acetyl esterase (deacetylase)  ali  100  1MAFFDLPLEELKKYRPERYEEKDFDEFWEETLAESEKFPLDPVFERMESHLKTVEAYDVTFSGYRGQRIKGWLLVPKLEEEKLPCVVQYIGYNGGRGFPHDWLFWPSMGYICFVMDTRGQGSGWLKGDTPDYPEGPVDPQYPGFMTRGILDPRTYYYRRVFTDAVRAVEAAASFPQVDQERIVIAGGSQGGGIALAVSALSKKAKALLCDVPFLCHFRRAVQLVDTHPYAEITNFLKTHRDKEEIVFRTLSYFDGVNFAARAKIPALFSVGLMDNICPPSTVFAAYNYYAGPKEIRIYPYNNHEGGGSFQAVEQVKFLKKLFEKG 325
2 -52.000[R] COG4287 PhoPQ-activated pathogenicity-related protein  ali follow..  13  36ISTKVYTLLHNNIFFCRNSPECDLSHVLPDYREQISGTPLKYTLIN-TAPLAQVVVRHYELLSVTPAQWRHNIYIPETA-KEHHALVVVNNGINYDKGVQISISRDTNTIVISVSDIPNQYLTFQDDKKPLKEDESVSRSWALFMEAPEQRKLMPLNIPMVTAISQAMRLAKKLTQWNINSFIITGISKRGWTTWLSAIADPDVEAIVPFAIDLLDIDASLEHIYQSYGGNWPITFYPYYQKSPAFTQLRQIIDPLRYQPRLAIPKYIINASGDDFFVPDNTRFYYSKLPGVKSLRIVPNMNHYSINQFAEGSLVPFINRFQSKK 394
3 -43.800[R] COG1073 Hydrolases of the alpha/beta superfamily  ali follow..  18  41............................SNTGGTNMQLQLTQEWDKTFPLSAKVEHRKVTFANRYGITLAADLYLPKNGGDRLPAIVIGGPFGAVKEQGLYAQTMAERGFVTLAFDPSYTGESGGQ--------------------RNVASPDIN-----TEDFSAAVDFISLLPEVNRERIGVIGICGWGGMALNAVAVDKRVKAVVTSTMYDMTRVMSKGYNDSVTLEQRTRTLEQLGQQRWTTPLSFMNMPILTYIKEIPRPILLIHGERAHSRYFSE--TAYAAAAEPKELLIVPGASHDRLDRIPFDRIAGFFDEHL... 367
4 -40.700[E] COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases  ali follow..  15  348..SISRGGDTIAYVKMGPTSPPDI------IYRDDNEYRLTDHNAWFAESRSLAEPVRLQVQSPLGGSIDAWILLPGECSGCLPWILYIHGGPKTSAFIHEFQMLASQGFAVIYSNPRG---------------------SDGYSEE-FADLRGRYGVDDYSELMKVVDALSDFPQLDPQRGGVTGGSYGGYMTNVIVTKTRRFKAAVTQRSCSNWISFYGESDIGWYFAP----ELISAQEPWRDLEKYVDFSPLFSVENIETPLLIIHSTEDFRCPLSGAIQLFTALGVETRLLVFPGENHNLSRSGTPRAIASWFKEHLGSQ 656
5 -35.800[I] KOG4667 Predicted esterase  ali follow..  11  1MRTLLHNFNFVPQDSPYYKTSPFPTSSFFNVRFPIKNNQISCNKAKNLRPSKGIQEQRIVIPNRHNEKLVGLLHETGST----DIVVLCHGFRSNKSMNNVAAAIQKEGISAFRFDFSGNGESEGSFYYGN-------------------------YNHEADDLHSVVQYFSNK---NRVVPIILGHSKGGDVVLLYASKYHDVRNVINLSGRYDLKKGIRERLGEDFLERIKQQGKSGYRVTEKSLMDRLSTDIHEACLKIECRVLTVHGSEDEVIPVEDAKEFAKIIP-NHKLEIVEGANHGYTEHQSQSTVMEFIKTVIVK. 307
6 -33.100[R] KOG4391 Predicted alpha/beta hydrolase BEM46  ali follow..  15  25..........................AFQEKLVYVPVLPGLSKSYPITPARLNLIYEDIWLQSSDGVRLHAWFIKMFPECRETLSCYDLDLRIPDIAHRLEMVMIQKLKCNVFMLSYRGYGASEGYPSQ----------------------------QGIIKDAQAALDHLSGRTDIDTSRIVVFGRSLGGAVGAVLTKNPDKVSALILENTFTS-----ILDMAGVLLPFLKWFIGGSGTKSLKLLNFVSPWKTIDAIAEIKQPVLFLSGLQDEMVPPFHMKMLYAKAAAQCTFVEFPSGMHMDTWLSGGEVYWKTNLQFLEK. 323
7 -32.400[Q] COG0412 Dienelactone hydrolase and related enzymes  ali follow..  14  25............................TTQQSGFAPAASPLASTIVQTPDDAIVAGFTSIPS-QGDNMPAYHARPKQSDGPLPVVIVVQ-FGVHEHIRDICRRLALEGYLAIAPELYFREGDPNDFADIPTLLSGLVAKVPD--------------SQVLADLDHVASWASRNG-GDVHRLMITGFCWGGRITWLYAAHNPQLKAAVAWYGKLTGDKSLNSPK-----------------------------QPVDIATDLNAPVLGLYGGLDNSIPQESVETMRQALRAKAEIIVYPDAGHAFNADYRPQRMLEWFKQYGGKK 291
8 -32.100[R] KOG1552 Predicted alpha/beta hydrolase  ali follow..  15  28..................PPEPTYKLTPADDTNIRYNLQLFDRAEWQYSEREKSKVEAFFTRTSRGNLITCIYVRCSKNAK--YTLLFSHGNAVDLGQMSSFYLGSQINCNIFGYDYSGYGMSGGKPSE----------------------------KNLYADIEAAWQAMRTRFNISPETIILYGQSIGTVPTVDLAS-RHEVGAVILHSPLMSGLRVVFRN--------------------TKRTWFFDAFPSIDKVAKVKAPVLVIHGTDDEVIDFSHGIGIYERCPKTVEPFWVEGAGHNELHPHYYERLRKFLSVELVK. 286
9 -31.200[R] COG2945 Predicted hydrolase of the alpha/beta superfamily  ali follow..  18  1.......................................................MPEVIFNGPAG-RLEGRYQPSKEKNA--PIALILHPHPQFGGTMNNFYMFQQRGFTTLRFNFRGIGRSQGEFDHGA---------------------------GELSDAASALDWVQAL-HPDSKTCWVAGYSFGAWIGMQLLMRRPEIEGFISVAPQPN-------------------------------------TYDFSFLAPCPSSGLIIHGDQDKVAPPKDVQALVDKLKTQKTQKTIASANHFFTGQGEEEECSEYLDRRLAG. 213
10 -27.300[R] COG4188 Predicted dienelactone hydrolase  ali follow..  13  45.............................................................DQSRNRRFYVDVYRPQRKEGKTPVLVFSHGLASRPDFDNAAEKMASYGFVVALPQHPGSDILQAQALLNRTSRQGYYPTE---------------FIDRPKDISYVIDELERRNALNLTQVGVGGHSFGGYGALAVAG-DPRVVAVLAANPVNSAI-------------------------------------GVSGLHKVTVPVLLLGGSYDPATPFLEQARSFPRLSRDKYLTLMEGQAHNLLHTYGSAVMVPFFQLYVAG. 332
11 -27.000[O] KOG2100 Dipeptidyl aminopeptidase  ali follow..  14  523.................................EHANLLYDKTYQNRVEEAGLPVIIKETIKISDDFDALIKLSIPKDKHQAIPLIVHVYGGPNDQNTKEAEVVASASQAAILRIDGRGSGGRGWKYRSAIYGQ---------------------LGTVEVEDQIKAIKVVLRRHLLDARRVAVFGWSYGGFMTLSMVNEAPEFKCAVSVAPV----------------TNFAYYDATYTERYMGDAPLESYSDVTKKLDNFKTRLLLMHGLLDDNVHFQNSAILIDELQNRGDLMVYPNQAHSLSSRTSHGKMTHFLRQCFYT. 797
12 -26.900[I] COG2267 Lysophospholipase  ali follow..  13  2..................................................ENSRIPGEHFFTTSDNTALFYRHWPALQPGAK-KVIVLFHRGHEHSGLQHLVDELAMPDTAFYAWDARGHGKSSGPRGYSP-------------------------LARSVRDVDEFVRFAASDSQVGLEEVVVIAQSVGAVLVAWIHDYAPAIRGLVLASPAFK-LARPALALWHRLRGLFFINSYVKGRYLTHDRQRGASFDPLRDAAAITLPTQLLISGDDYVVHRQPQIDFYQRLRSPKELHLLPGFYHDTLGEENRALAFE......... 273
13 -26.200[R] COG1647 Esterase/lipase  ali follow..  13  7..........................................................................QPFLFEKGKRAVLLLHGFTGSSADVRILRFLQENNYTCYAPQYRGHGVSPDLLLKTGPND--------------------------WEDVLAAYDHLKSL---GYTEIAVAGLSLGGLFSLKLGFSRPLKGIIAMSTPTRMDSSSPIIQGFLDYVRNYKKLEGKTPEQIDAEMVAYKDAPMNTIIDMIYAPIMVVQGEKDDMVDVSGAQLIYDTVESTKELHWFKESGHVITLDKERKDVNQAILTFLDS. 243
14 -25.200[R] COG3571 Predicted hydrolase of the alpha/beta-hydrolase fold  ali follow..  12  1....................................................................MNGKFLFDGPGDAP-VTILLAHGAGAPMDST--AMALAGVGFRVARFEFGYMAARRTADGRKPRPA---------------------------RKTLNPEYRAAIAELGAQGTLVIGGKSMGGRVASMVADDLHAEGKIAGLLCLGYPFHPPGKPDQ----------------------------LRTRHLTDLKTPALICQGTRDEFGTRDEVSRY--ALSDRIELLWLEDGDHDLKPRKTVEAVARWADRLA... 212
15 -24.900[I] KOG1455 Lysophospholipase  ali follow..  13  55................................................GGDGSSVRDFSLFTTKRGDTLFTQSWTPVDSAKNRGLVVLLHGLNEHR-YSDFAKQLNVNGFKVYGIDWIGHGGS---------------DGLHAYVPS---------LDYAVADLVIA--------ENPGLPCFCIGHSTGGAIILKAMKIEARVSGIVLTSPAVG-IAPFLSFLIPRYQLSAAKKKIMPVSRDPEALLAKYS-DPLVYLNRIKVPFLVMHGTADTVTDPKGTQKLYNEASSDKSIKLYDGLLHDLLFEPERETIAGWLNRRV... 333
16 -24.400[R] COG4757 Predicted alpha/beta hydrolase  ali follow..  13  2....................................................HTDAFPVSLAAADGYVLGGCRYPADTALK--GRLVVAGATAVPQGFYRRFAFAGTRGFETLTFDYRGIGQSRPPSL---------------------HGLRTDFLDWARLDLAAAVDTMAD----GAVPLYVVGHSYGGHAFGLLPNHRKVAGFCVFGTGWKGYCPWKMLGLGEDLPVGVYRQWRHWCRFPRYLFDDPAMRGIEQAYADVRTPIVAVNALDDLWAPPASRDAFMQGYRNAPLTRKDGKVGHRQAGEPLWERMLGWFSSLPRTT 287
17 -24.400[R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)  ali follow..  14  1.....................................................MPYVTVGQENSATIDIY-------EDLGAGQPIVLIHGFPLNGDSEKQVLVLLNAGYRVITYDRRGFGASSQPS-------------------------SGYDYDTFAADLHTLMTKL------DLQNTVLVGFSMGTGEVTRYLGKSERVQKAVLMAPVPPFLLKTNDNPEGVDQSVFDGIMKAIVDDRPAYFSAF-LTDFRDDLPRIDVPTLIIHGDADRILPLESTAARLPKRIKNSQLEIIPGGPHAINWT-HADQVNPLLLNFLQ.. 276
18 -24.000[R] KOG4840 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)  ali follow..  12  30.............................................................................TSNVTRSLLLFVGGLGDGPYVQELVNPLDEIGWSIVQVQTQSSYIGWGTGSLKR----------------------------DDEDLHKAVDYFLHIADFSTRKIVLMGHSTGSQNVLYYLT-PNYLIAGIAQAPVSDREAAYQFNGKEKTKELVDWVKAEYLDKSADDFAKTFGNLKEISGSTAHSQLILLMSERDEFVSPSTDKAQLPTTSNSSLSGIIPGATHNVGPKSSPNQLITALRSFIDQ. 316
19 -24.000[R] COG2936 Predicted acyl esterases  ali follow..  14  6...............................................EFPRKVVEFPDMGIVMPDGCRLSARVWMPEDANDPVPVILEHLPYRTIFRDQLTHPYFAGHGYASIRVDMRGNGDSEGL--------------------------DDEYSEQELQDACDVIAWAVAQPWCNG-NVGMMGISWGGFNCLQVAAKQPALKAVISLCSTVDRYADDIHYKGGCLLIENFGWASTMLSYSSR--AYWKRGSICEDFSAVKAAVLSIGGWHDGYR--NTISNLVSNIEAPVKGIVGP--IHKYPHYAGPQEALRWWDRWLKG. 301
20 -23.000[Q] COG3509 Poly(3-hydroxybutyrate) depolymerase  ali follow..  12  38..............................................................DVDGAGRSYRLYKPVGLPSSAPLVVMLHGGFGSAKQAERSYGWDSEKFLVAYPDGYHRAWNANGGGCCGRPA-----------REGVDDIG----------VRAVVADIANNVSIDPARVYVTGMSNGAIMSYTLACNTSIFAAIGVVSGTQLD----------------------------------------PCQSPRPVSVIHIHGTADPLVRYHGVTTSGATCADNRRVVLLDDAGHRWPSFATQT-LWRFFAAHFR.. 280
21 -22.900[R] COG0400 Predicted esterase  ali follow..  11  3........................................................................HIFRKGADPNAPTLLLLHGTGGNEHDLVPLAEMISPGSSILGVR----------------GNVLENGMPRFFRRIAEGVFDEEDLVIRTKELHEFLDDAVREHAINRNRLVAIGYSNGANIAASLLYHYEQPLMGAI------------------------------------LFKAMVPLRNRTVPDLQQMPIFIGAGKYDPLIPQTETKELINTLTNAGANVYEQDVGHQLTRE-EVERAKEWFNEQFLEA 204
22 -21.900[E] COG1770 Protease II  ali follow..  14  397....NWVSPKLRIRAGSFVTPV---RVYDVDLATGERTLLREQPVLGGYKHEDYVERREWAQADDGTWIPVSIVHRAAIRFPAPAVL--YGYGADPSFSIPRLSLLDRGMMFVIAHVRGGGEMGRL-----------------WYEHGKLLEKK----NTFTDFISVAKHLVDSGQTRSQELVALGGSAGGLLMGVVANIAPDLTGILAQVPFVDPLTTMLDPSLPLTVTEWDEW---NPLIDSDFYSYIKSYSPYENVEAKQYPILAMTSLHDTRVHYVEPAKWIAALRHTKSLKTQMAAGHAGISGQETAFQYAWLLAAVD.. 705
23 -21.600[R] KOG1454 Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily)  ali follow..  8  27.......................FPTFLPKEIQNIKDPFARALAQRIVRIPVPLQMGNFRGSVMSSCIKP-------VQLHDKSPVVLLHCFDSSCEWRRTYPLLEQACLETWAIDVLGWGFSDL-------------------------EKLPPCDAASKRHHLFEL-----WKTYIKRPMILVGPSLGATVAVFTATYPEAVDKLVLINAVLAFCSSPLSENIDWTNIGRLHCQMPWWEDAMVDFMISGGYNVASHIKHIDHKTLVVCSENDQIVSNQLSVKLLCELAN-AVLREVPDSGH-LPHVENPKHIVKLISDFASG. 326
24 -21.200[R] KOG3043 Predicted hydrolase related to dienelactone hydrolase  ali follow..  14  30....................................................................LDTYAAGSTSPKE--KVIVILTGNKF-NNVLLTADKFASAGYMVFVPDIFGDAISSDKPIDRDAWFQRHSPE------------------VTKKIVDGFMKLLKL--EYDPKFIGVVGYCFGAKFAVQHISGDGGANAAAIAHPSFVSIEEI--------------------------------------AIDSKKPILISAAEEDHIFPANLRHLTEEKLKDTYQLDLFSGVAHGFAARGDILDQIYWFNHFSN.. 245
25 -21.000[R] KOG4409 Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily)  ali follow..  12  108....................PSKSQRLAEAEGRILSALGIKYLARLIQIPFKNTEISTITVN----------CESEQPIVKAKYPIVLIHGFGAGVALWGSAIKRLAQFQTVHAFDLPGFGRSSRPKF----------------------SSDPETAETEMIDSIEQW-----RDKMNLEKMNLVGHSFGGYLATYALKYPKRVENLILADPWVRRLRPDLALKYSEDVYDYIYLANSRDPTGEEVFKCLSENLGWAKQPDNTVPVTFIHGERSWI-DWRTTRRLFGELE-HVESHIMDSAGHHVYAD-DADKFVQLVIGSLKDG 424
26 -20.900[E] KOG4627 Kynurenine formamidase  ali follow..  12  3....NPRCKDLDRDYFPSYHTTRFQDQPEPNLAVLEHVRVTKQHGRELTEKQGITVDHLRY-GEGRQLVD--VFYSEKTTNQAPLFVFVHGGMDMSMSCSIVGPLVRRGYRVAVMDYN-----------------------------------QVTLEQLMTQFTHFLNWIFDYEMTKVSSLTFAGHSAGAHLLAQILMRPKMVWALIFLCGVYD-----LRELSNLESVNPKNILGLNERNIESVSPML--WEYTDVTVWNSTKIYVVAAEHDSTTFIEQSRHYADVLRKKASFTLFKGYDH...................... 276
27 -20.300[R] COG3150 Predicted esterase  ali follow..  10  1..................................................................................MSTLLYLHGFNSSPRSAKASLLLAEHHPDVEMIIPQLPPYPSDAAE----------------------------------------LLESIVLEHGGDSLGIVGSSLGGYYATWLSQCFM--LPAVVVNPAVRPFELLTDYLGQNENPYTGQQYVLESRHIYDLKVM------QIDPLEAPDLIWLLQQTGDEVLDYRQAVAYYA----SCRQTVIEGGNHAFTGFEDYFNPIDFLGLH.... 191
28 -20.300[R] COG0429 Predicted hydrolase of the alpha/beta-hydrolase fold  ali follow..  12  29.......................................LQTMLPRLFRRKVKFTPYWQRLELPDGDFVDLAWSEAPAQAQHKPRLVVFHGLEGSLNSPY-VEAAQKRGWLGVVMHFRGCSGEPNR-------------------------MHRIYHSGETEDASWFLRWLQRE--FGHAPTAAVGYSLGGNMLACLLAKEGNDLPVDAAVIVSAPFMLEAQLKSVRRIREFDDLITARIHGYADAIDYYRQCSAMPMLNRIAKPTLIIHAKDDPFMDHQVIPKPESL-PPQVEYQLTEHGGHVGFIGGTLLHPQMWLESRI... 327
29 -20.300[I] KOG3847 Phospholipase A2 (platelet-activating factor acetylhydrolase in humans)  ali follow..  13  26...LMIEEAAGSGLFMRLFFPTDSEITGPSSLPVWIPRPEYAYGVGEYLGHSPHQMDLISSLVIGDKRVDCIDNAQSTKSDKWPVLVFSHGLGGSRTFYSTYCTLASHGYVVAAVEHRDSSACWTYKLVEKNGTLVEKPMKIKLVDRNDKDQFKIRNEQVAEECAKAVKILEQLDSLLTTTASIIGHSFGGATSIASSSSDFQKAIVL---------------------------------------DGWMYPLDQNQQEQAKQPIMFLNVGDWQWNENLEVMRKILPNNEGNILLTLSGAVHQSFTDFAIELTLSFLKDGKDG. 359
30 -19.800[E] COG1505 Serine proteases of the peptidase family S9A  ali follow..  13  418....SDEGDLVFYTDEGFATPT---QLKLADATGTTAQTIKA--LPAQFDASKLEVEQKVATSKDGTKIPYFLIHPKGHDGKNPLLL--HAYGG-VYDPLIGKLWLERGGSYAVANIRGGGEFGPG-----------------WHQAALKANRQ----RAYDDYFAVAEDLIAKKITSPRHLGAYGRSNGGLLMGVAMTQRPDLNAVIVESPLLDMIRYTQLPAGASWIGEYGD------PAIPAERAWIEAYSPYKLKAGVKYPAYITTSTKDDRVHPGHARKFAARLDDLKVYFENTDGGHANGADRRWALHYTHLSRQLM.. 721
31 -17.900[R] COG4099 Predicted peptidase  ali follow..  14  191............................................................YDEKTGKKLKYNLFIPKDPDKAWPLVLFMHDAGATSD---VTRTTLYQGLGAIAW--------ASPEDQAQRPCFVLAPQYEEIIADDDSKTSDM-----LDTTIDLINVLSEQYNIDKSRIYATGQSGGCMMTIAMNIKYPDFFAASFLV--------------------------------------AGQWDPALVKPLAQQKLWILVSQDDNKAWPNAIIDVLEKEGVQISRAIWDGTWNE..................... 396
32 -17.800[I] KOG2112 Lysophospholipase  ali follow..  10  1............................................................MAAASGSVLQRCIVSPAGRHS--ASLIFLHGSGDS-----------GQGLRMWIKQVLNQDLTFQHTAPPRSYTPMKGGISNVWFDRFKITNDCPEHLESIDVMCQVLTDLIDEEGIKKNRILIGGFSMGGCMAMHLAYRNHQDVAGVFALSSFLNKASAVY-------------------------------QALQKSNGVLPELFQCHGTADELVLHSWAEETNSMLKSTTKFHSFPNVYHELSKT-ELDILKLWILTKLPG. 231
33 -17.500[R] KOG2564 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold  ali follow..  12  17......RADSFKKSRIRDYKPGMWNEFFAEK-------------------------EDVTVDEQRTFRIY----RTKQPEKPGPVLLLLHGGGYSALTWAHFCS-SMIHCQCLCIDMRGHGDSKVD------------------------DEDDLSADTLAKDIGDLILKLYPE---EVPQLFVVGHSMGGAIAVHFAHMALVPNLIGI---TVIDVVEGTAMEALASMQSFLRSRPKYFQSIPNAIEWCIRSGQVRNVDSAKYWVGWFSGLSDKFLNLRLPKQLLGQMQGRFQMQVLARCGHAVHED-RPHEVAEVISGYLIR. 385
34 -17.200[R] KOG1838 Alpha/beta hydrolase  ali follow..  10  60..................NPNSDFCKFIVSKCRLLHGR-LQTAFLTLFGKSPPFSYKRILYQATDGGTIALDWLMHSDGTDRTPIAIIVPGLTSDSSAAY-AFRLAKEGWNVVVQNHRGLGGISLT-------------------------SDCVYTAGWTEDLRKVIAHIHSQ--FPEAPLFAVGTSIGANVLVKYLG-NTPLIGATAHHSIISRIADWEGIKKSRSVREFDNYATRLVAKFETTDTYYRRSSSSQYVENVAVPLLCISALDDPVCTREAIPWDECRANKNIVLATTTHGGHTASSMWWTRVVHEYFEVLLSS. 412
35 -16.500[U] COG3946 Type IV secretory pathway, VirJ component  ali follow..  9  254........................................................................EVPSKAQKKSDTFAIFVSGDGGWAEIDKKVAHLADADIPVVGLDSLRYFWSERTPE------------------------------GFAKDLDRIARFYAHH---KRNRLLLVGFSQGADVLPAAINTRQIIRMTALLSLGKY--------------------AHYEFHVSNWISTDDEGIPIAPDMVKLSTRTVCIYGVDDQE-------TLCPSLPQQNRRVALPGTHH----NGDYETVAKTILAQMEAA 451
36 -16.200[V] KOG1515 Arylacetamide deacetylase  ali follow..  10  85...LEPSTSACVYSGKARTLNNIAGSDLLSRRNSLGSSNSLLSHKVESRRNSYGYTTGSSSPEAGS-SDVYRGYAPSSSSRKLPVMLQFHGGGWVSGSNDSVAN-KHCDIIVLAVGYR---------------------------------APENRYPAACEDGFKVLKWLGKQANADPSRCVLLGVSCGANIADYVARKAIKVVAQVLMYPFFIGSVPTQSEIKQANSYFYDKPMCILEEEFSLDHQAANPLVPGRSPPLKFMPTLTIVAEHDWMRDRAIAYSELRKVNVDAPVLEYKDAVHEFQAQACAEDIAIWAKKYISL. 453
37 -15.700[R] COG0627 Predicted esterase  ali follow..  12  29..................................SALIGVVGSAPAEAFSRPGLPVEYLQVPSPSGRDIKVQFQNG---GANSPALYLLDGLRAQDDFSGTAFEWYYQSGISVVMPVGGQSSFYSDWYSPACGKAGCQTYK-----------ETFLTSEL-------PQYLQSNKQIKPTGSAAVGLSMAGLSALTLAIYHPDQFIYVGSMSGLLDPSNAMGPSLIGLAMGDAGGYKAADMWGPSTDPAWKRNDPTVNVGTLITRIWMYCGNGKPTELGGKFQDGYNAGGGHNAVFNFPDSGHSWE-GEQLNDMKPDLQQYLG.. 325
38 -15.100[I] KOG4178 Soluble epoxide hydrolase  ali follow..  13  6........RKLSLSRFRHHFPLRLRRFLGENPNPTTHFSTLPDNQTKRPEKSRLDGVEHKTLKVNGINMH-VAEKPGSGSGEDPIILFLHGFPE--TWRHQMVALSSLGYRTIAPDLRGYGDTEAP-----------------------EKVEDYTLLKRGRSVVALIVAVTG----GDKAVSVVGHDWGAMIAWQLCQYRPKVKALVNPGPLNLPKDKYFKRSENAASALPLWLTQEDLDYYVTKYENKGFTGPINYYRKIRVPVKFIIGDQDLTYNFPGAKEYINGGGFKRDV.............................. 339
39 -15.000[R] COG2819 Predicted hydrolase of the alpha/beta superfamily  ali follow..  12  26..............................SYAQPDMQPLGPNIADKGSGYYHFRVNDFQ-SADGARHYRVWTAIPNKPPSGYPVLYMLDGNAVMDRLPETLLKQLADHSPPVIVAIGYQTNLPFDLNGRAYDYTPAPGIDRDDSENNPRFHRKTGGGPAFRQLLHIAPQVEQGITINSERRGVWGHSYGGLFVLDSWLSSSFFHIYYSASPSLSRDNFVL----------------------------LNRLTTVKPSLFCHKKLIIMEGSASNGDSAELLQKVQETVRTLEALQHYPGLGHGPMFNASFRSALLDI....... 299
40 -15.000[S] COG2830 Uncharacterized protein conserved in bacteria  ali follow..  9  7..............................................................................DYQGEHLILYFAGWGTPPDAVNHLILPENHDLLICY------------------------------------------------------DLNLDFDLSAYRHIRLVAWSMGVWVAERVLQ-GIRLKSATAVNGTGLPCDDSFGIPDKASFERYQLFPARPFDEIHQELTALFAMIQQDKRIDLIHWANAWVSSRDKIFTPANQHQYWA----LRCAVQEIEGEH...................... 200
41 -14.300[E] KOG2551 Phospholipase/carboxyhydrolase  ali follow..  11  1........................................................................MAPEIHLKPKNPRILCLHGFRTSGR--------------ILQAGIGKWPDTILRDLDLDFLDAPFPATGKSDVERFFDPPYYEWYQKEYRNFEECLAYIEDYMIKNGPFDGLLGFSQGAFLTAAIPGMQEQ-------------------GSALTKVPKVKFLVIISGAKIPGLMFGEPKAAVNAFSSPVRCPSLHFIGERDFL--KIEGEVLVESFVEPV--VIHHSGGHIIKLDTKAEETMLSFFQSIRQM 222
42 -14.100[S] COG4947 Uncharacterized protein conserved in bacteria  ali follow..  10  2.............................................SMRKRPETMDISYHKHFSGKGRDMEYKRYGHAG----RPVVVFPTSQGRFYQFEGALAEFIDTGRIQLFTVDGIDSESFFDKHADTAHRIGRHEAYFRYVRE---------------EALPEILSTASAANGRKLKPLFSGCSMGGYHSSNFVFRFPELASGVISLSGVYSARDFFG-----------KVLDGDIFYNSPLDYLPGIVDPKLLARLKALRLIFCCGQEERMLVETRQLQILRDKSIPAWVDYWGGDVHDWP----HKQLVYFFGRWLDD. 260
43 -13.700[R] KOG2382 Predicted alpha/beta hydrolase  ali follow..  11  14.............................................................HSDSTSSMMLANLTFGNMRSKGTPLILVPGFGTKENWIQVGKDLSQRGCMVFAVENRNHGSF--------------------------SKAASMTYEEMADDLVGFIDWVRKITGED--KVNLHGHSMGGKAVTQLAEYSSRIKSLIVELECIKQMIATDMNKSRSEVMAELGEKVSKVLLYQFVRGNLGEDVNGKAHWICNLPTLFQRAPGSGFLPAAHKNRVEKMFP-MVQFAETAWSNHWIHAD-DPKFFVDSICEFLEE. 287
44 -13.500[I] COG2272 Carboxylesterase type B  ali follow..  14  30IPYAAPPTGELRWRAPQPVTP------WHDVRQADCFSCASWQDITWCRELGGGDPGNF---SEDCLYLNVW--APAVRHEPLPVMVWLHGGGAGSLPPYDGQALAKRGAIVVTVNYR---------------------GHLGFFAHPALEGEEAECIHNFLDQIAALRWVQDN---DTQNVTLFGESAGARSVLSLMASPLAFHKAIIQSGY------TLPDTPREVALKKGVALAEHLGLAHATAEQLRALPAETFWPLDAPFKIAPTPISGDVVLPHPMLETFFA-AKQHPIPVMIGSNSD..................... 307
45 -13.300[I] COG0657 Esterase/lipase  ali follow..  11  46.........................................................GVDVSCEVLANIETDVLSPRFLMVG--AVLYAHGGFFISGSPMASRALCASGAKFYIPAYQ---------------------------------APEHPFPAALENMYDAYVALIDQKKFRPEDIIFSGDGAGAGLMLALTHYLKQCPRALALISPWVDLTEDRFAGEGVKKKELLLTRDMFRYCALQYTYADNFRNSLVSPLFGNFPVFVQCGEQELFHTDACALAILEGAGVQVTLDVWPGMWH--CAHIAVARMGAWAHRMLESP 302
46 -12.800[P] COG2382 Enterochelin esterase and related enzymes  ali follow..  12  91.....RKLLPQAIADPLNLQSWKGGRGHAVSALEMPQAPLQPGWDCPQAPEIPAKEIIWKSERLKKSRRVWIFTTGDATAEERPLAVLLDGWAQSMPVWPVLTSLTHRQAVYVLIDAIDTTHRAHE------------------------PCNADFWLAVQQELLPLVKAIAPFSD-RADRTVVAGQSFGGLSALYAGLHWPEFGCVLSQSGSY------------------------WPHRGGQQEGVLLEKLKAGEVSAEGLRIVLEAGIREPMIANQALYAQLHPIKESIFWRQVDG-GHDAL----RGGLMQGLIDLWQP. 368
47 -12.100[R] COG4814 Uncharacterized protein with an alpha/beta hydrolase fold  ali follow..  10  31...........................................................................PKAANDAIP-TIFIHGYRGTDRSLHGMIRRFDQGTESLTVNVSPDGSISTTGTYSKNEKNPLINIVFEDNRATLPQQSMW--------TKKIMSYLQKNYDIK--KFNAIGHSMGGGAWVSYLA-YPQVNKIVFLAVPFYPEEYVNGDQQVDIKNANNVHAKFAQKMAKVLPDNTEIMIIGGDLE--------DGSNSDGEVKLNSVLYLFAHQKVITHVIKGPKATHSS----ESTVVDKYVGQFL... 269
48 -11.600[I] COG4553 Poly-beta-hydroxyalkanoate depolymerase  ali follow..  9  102...........................................................................IRMLKDEPVVLVCAPLSGHHSTLLRDTVRTLLQDHKVYVTD-------------------------------DARMVPVGAGPFHLSDYIAYIREFIA--HIGADKLHVISVCQPTVPVLAAISLEKTPLTMTMVYPGFLQHAGFVAMNPDRHVSSHYDYYLSLVEGDKEDAEAHVRFYPVRPQDIKGTALFTIEGELDDISGSGQTEAAHDLCSSIKQHLTASNCGHRRWREFVYPQLRDFIRRY.... 412
49 -10.300[I] COG3243 Poly(3-hydroxyalkanoate) synthetase  ali follow..  10  285.........................................................................YAPTTEKVFKPPLLIVPPWINKNPQKSFVGWCLEQGHSVFMVS---------------------------WINPDAGLANKGWDDYINEGIDFALDTIEERT--GEKQINAIGYCVGGTLLSSALALNERIRSATLLAAQTDDLLYWNSDSTRVTAASHSFYLRNCYLENNLARGLMRVAGKRINLGDITIPVYDLATRDDHIAPAKSVFTGAALFGGTVEFVLGAS-GH...................... 559
50 -10.200[Q] COG3208 Predicted thioesterase involved in non-ribosomal peptide biosynthesis  ali follow..  9  1.........................................................................MMRGAPMTLRPRLICLPPAGAGPSLFRSWVQNSESIFDVVPVALPGREAHFTKPLPRDIQS-------------------------LADHVTNEIIGLLQAP------YALFGYSMGAVVAYELLRLPLPDAFYILGSNAPDRVLEGREPIHSMTSEDFQQSLVEIGGTPDEILRICETYEFTPPHLPVTFPVHVFVADADHLVSWKAAGAWENCIGQDITMHGIEG-SHMLPPQ-AFAHFIGKLGQLWQT. 241
51 -10.100[I] KOG2624 Triglyceride lipase-cholesterol esterase  ali follow..  12  94.....................GDTDPSPTERPVESPTRLYNSMNTDTRTCQDVITELGYPYEAIRVITSDGYVLIPRRDAR--KAVFLQHGVLDSSMVGSPAFAAYDQGSSLKFWRYSIN----------------------EHGTEDIPAMIEKIHEIKTTEL-PNIDEEINQE--EPYKLCAICHSLGGAAILMYVIKPHRLSRLILLSPYNMNDMPAVSFRVAQHLAQIKHTGKFRMYDYGSRSANMEVYGSPESYKFIDVPVDLVAGRNDKVIRSSMVKKHYNVMRDAEVDVSFNEFAH...................... 460
52 -9.870[R] KOG1516 Carboxylesterase and related proteins  ali follow..  11  50IPYAKPPVGDLRFRAPQPPEP------WQGVLNCTTNRSKPMQRNMLLGIVEGSE-------------LHLNVYVKAKSEKPLPVIVWIYGKGEASRDIYSPDYFMKKPVVFVAINYR---------------------AALGFLSLK-DPKLDVPGNAGLKDQVMALRWISQN---DPNNITLMGESAGSASVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWAFRLAQNLGYKGDEKDADVLSFLSKVCARQIAAIDQGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIV............................ 334
53 -9.680[E] COG2021 Homoserine acetyltransferase  ali follow..  10  1.....................................MPTVFPDDSVGLVSPQTLHFNEPLELTSGKSLAVIETYGELNATQSNAVLICHALSGHHHAAGYHKPIDTRKFFVVALNNLGGCNGSSGPASINPATGKVYGAD--------------FPMVTVEDWVHSQARLADRLGIRQ---AVVGGSLGGMQALWTISYPERVRHCLCIASAPKLSAQNILKTEKLNYDLHSVEFQVESYLRYQGEEFSTRFDANTYLEGVEADFCLMSFTTDWRFSPARSREIVDALIAVSYLEIDAPQGHDAF---PIPRYLQAFSGYMNR. 376
54 -9.650[T] KOG4389 Acetylcholinesterase/Butyrylcholinesterase  ali follow..  11  70IPYAKPPVEDLRFRKPVPAEP------WHGVLDATRLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPANTTNGLPILIWIYGTGSATLDIYNADIMAAVGVIVASFQYRGAFGFLHLAPEMPSEFAEEAPGNVG-----------------LWDQALAIRWLKDN---NPEWMTLFGESAGSSMSPVTRGLVKRMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTISVQQWAPTI------DGAFLPADPMTLMKTADLKDYDILMGNVRDEGT................... 407
55 -9.610[R] COG1075 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold  ali follow..  10  6...........................LEFSDLNFSGCVELINFISYKLMKKMLAVNMIALVMLTGMGVASAASKDSYAATKYP-IIFEPGFGGVDRLFVLIDYFRAHGANVYLSTSSAFQRPDGPNGRGE-------------------------------QLLAYVKAVLA--ITGAEKVNLIGYSQGGLTVYVAAVAPSLVASVTT.................................................................................................................... 169
56 -9.540[IO] KOG2541 Palmitoyl protein thioesterase  ali follow..  7  12....................................................................VVVAFLAKVDISVSVP-FIMLHGIASQCSDDTNAFTQLLTNLSGSPG----------------------------FCLEIGNGVINSMFLPLTQQAEIACENVKEMKEL-SQGYNIVGRSQGNLVARGLIEFCDGGPPVFNYISLAGPHAGISSLPRGLCGDHLAPSGYYKIPNDMK-----QYLERSKYLPKLNNELVLVKFQDDEVITPNDSTWFLKTLDDAGKVKFVSVPGH----RMAEEDVVKYVVPYLQN. 275
57 -9.520[OE] KOG1282 Serine carboxypeptidases (lysosomal cathepsin A)  ali follow..  11  83..........................................................VAVNEPATRFLYYYFVEAIKPSKSTPLVLWFNGGPGCSSVGFGA--FEELG---FRVHSDGKTLYRNPYSWNNEANMLFFEGPISVGFSYSSTPFDWEIFGEQADKLTAEDWLERFPEYKGRDVYISGQSYAGHYIPQLAQI--NLRGISIGNPGLDNVQEAMHANTTKLPYEWKACNHYLNSVWIDADKDASMVPILHDLMGEGVRVLVYSGDVDAAIPFTATMAVLKTMNRNLTYATVKGSGH-SVPLDQPVHALNLFTSFIRN. 480
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Rychlewski L, Ye Y, Jaroszewski L, Godzik A. Integrated web service for improving alignment quality based on segments comparison. BMC Bioinformatics. 2004 Jul 22;5(1):98.