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Query: [R] COG3481 Predicted HD-superfamily hydrolase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSGDIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFLETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGLAYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGHISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNLDAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHKLast
1 -114.000[R] COG3481 Predicted HD-superfamily hydrolase  ali  100  1MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSGDIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFLETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGLAYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGHISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNLDAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK 314
2 -19.500[S] COG3294 Uncharacterized conserved protein  ali follow..  12  1............................................................................................................MQTLTYEVGVKLIEKVLPDSEKVKKVW-TEVQAYLKMANVFAVQRLRYNDHGPVHSRIVAGSALAIYKIDWEDSIIVTLMGAYLHDIGNSVHRTHHPIYSAVLTDRIAE------KILSKIYGSTEKMYMLKQEIMHAVFCHDEAYN------CLTFEAACAKIADGTDMSSGRAR.............................. 185
3 -17.800[R] COG2316 Predicted hydrolase (HD superfamily)  ali follow..  18  9....................................................................................................................................................ELLKTHVKTKNLVKHCLAAEAVMRALAREF-NEDEEKWGLAGLLHDLDYDYTKDKPEE-----------HGLKTLEILKDE--------DVPEDVLNAILAHCEKKT------PETLMEKALYAVDPTTGFI.................................. 114
4 -17.400[L] COG2254 Predicted HD superfamily hydrolase, possibly a nuclease  ali follow..  12  16...............................................................................................................................................................MEDHIRKGLEIIEGLYLRRGYGHEELLKKAYIFHDIGKCLEE-------QQRREKFRFHEVYSALVAREVFKKYG---DIGGVVSVAILLHHHNWIREKSPKRPRNLKLCNECLSIIKKLSGE................................ 142
5 -15.800[R] COG4341 Predicted HD phosphohydrolase  ali follow..  13  1.....................................................................................................MSGQDLNADNIVEFIADIFERRGAES-------------------------YLGEPVTMSEHMLQGAWLAEQ--------APEALVAAALLHDIGHYTS---EFGTYSPDDVEDKHHDEAGGEVLAPFFPP---------VIVECVRLHVAAKRY---KNPFHEEAVRVRIWDEGGKVANMKTRAFRDYVP...................... 181
6 -14.900[R] COG1418 Predicted HD superfamily hydrolase  ali follow..  14  175LMETENKLTHEIATRIRDAERDIKDRTVKTAKDLLAQAMQRLAGEYVTEQTITSVHLPDDNMKGRIIGREGRIRTLESLTGIDV------DTPEVVILSGFDPIRREIARMTLESLIARIEELVEKNRLEMDNRIREYGEAAAYEI-GRLQFRTSFGQNVLRHSVEVGKLAGILAGEL-GENVALARRAGFLHDMGKAIDREVEG-----------SHVEIGMEFARKY--------KEHPVVVNTIASHHGD------VEPDSVIAVLVAAADALSSA................................... 444
7 -13.200[H] COG1713 Predicted HD superfamily hydrolase involved in NAD metabolism  ali follow..  13  27................................................................................................................................................................LTHCLGVERAAMELAQRF-GVDVEKASLAGLLHDYAKKLS-RYQLDPDLKNWGNNVWHGMVGIYKIQEDLDLHD------SEILRAIEIHT------VGAGQMTDLDKVIYVADYIE..................................... 138
8 -12.900[O] COG2844 UTP:GlnB (protein PII) uridylyltransferase  ali follow..  10  313MKDYFRVTRRVSELNQM-LLQLFDEAILALPADEKPRPIDDEFQLRGTLIDLRDETLFMR-QPEAILRMFYTMVHNSAITGIYSTTLRQLRHARRHLQQPL-PEARKLFLSILRHPGAVRRGLLPMHRHSVLGAYMPQWSH--IVGQMQFDLFHAYT----EHTIRVMLKLESFVDVWPRLPSELIFIAALFHDIAK---------------GRGGDHSILGAQDVVHFAELHGLNSRETQLVAHLLMSVTAQRRDIQDPEVIKQFAEEVQTENRLRYLVCLTVADICATNETLWNSWKQSLLRELYFA..... 620
9 -12.800[T] COG2206 HD-GYP domain  ali follow..  13  25MSQKISELQEGMCFSEPVFFDDGENLLLREGEPVSTRELTAGRVLAEGESVPSSTVEELAEFEELAAEELLDPEDDIVSTGELRTQDILKDICELLPKVCINPHYHEEYVGFIQELNMLFAKMNDMLAKRLSELVRANTLGFVSLVLSYKIEGFRF----AKPAVDTAIFSIIVAQHLGFSEKDILVVASLLHDIGMQH-LKKSGRLHFQEQQAVDAHTIYAHSYIVNT-------LKYPNSVGLSVLQHHEHWN-GYPQSLSGNKARILAVTDNFAAMLA................................. 329
10 -12.800[KT] COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain  ali follow..  14  76....VDDSPDNIAFMSQGLAQYYRIKAARSGKVALDLVLLDVMPEMSGYEVINQIKHNPHTEHIPVIFLTGKSNPEDEQLGFELGAVDYVFKPVSIPLLKSRVHTHLQNKRSKDILLNQNDYLETE-VLRRSGELDRMQDAVVFALASLAETRDPETGN---HLLRTQHYVKVLAQRLSPTVIDTYFKAAPLHDIGKV--LLKPGKLTPDEFTTMRNHALLGKLALEKAEKLSGACTALINVAKEIAMGHH--EKWDGSGYPL-LSARLMALADVYDALICR................................ 377
11 -12.700[R] COG1896 Predicted hydrolases of HD superfamily  ali follow..  12  68..............................................................................................................................................................NISEHSLQVAFVAHALAVIKGTLNPERIALLAMYHDTSEVLTGDLPTPIKYFNPEIAKEYKKIEAAAERRLLDMLPEELRDDFRP------------FLISNTADPDESAIVKQADAICAYLKCLEELSAGNHE...................... 194
12 -12.400[R] COG1480 Predicted membrane-associated HD superfamily hydrolase  ali follow..  19  483.......................................................................................................................LSNPNHPLLRKIL-----------TETP-----------GTYHHSVMVANLSEAACEAV-GANGLLARVGAYYHDLGKTKRFIENQMNIDNPHDKLISHTTDGANMLRSY--------KFPKELVDIAEQHHGTSRYPGPK-PQSKEAAIISVADSVEAAV----RSMHNPNPERIEKLVRGIISDKLQDGQFSE 674
13 -12.400[S] COG3390 Uncharacterized protein conserved in archaea  ali follow..  14  40.........TGAKVNRIFIVGTLEKEDIGTDSEYWRGRVSDPTGSFLVYAGQYQPEAAEECELPAFVAVIGKTSTYTTDAKQTLERIKAVDAQEDPNSKLAKEHYSTDIAIYREMVKKALESLKDD............................................................................................................................................................................................ 188
14 -12.100[R] KOG3197 Predicted hydrolases of HD superfamily  ali follow..  18  93..............................................................................................................................................................SIADHMYRMALMALIAGDL-TGVDRERCIKMAIVHDIAEAIV------------GDITPSDGVPKE--EKSRRETAALKEMCEVLGGGLRAEEITELWLEYENNASLEANIVKDFDKVEMILQALE.............................. 203
15 -10.800[L] COG5235 Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit  ali follow..  16  43...TIKQILENQELHHVCFV---VVRNITDHTANIFLTIEDGTGQIEVRKWGYGSQVAQQFEIGGYVKVFGALKEFGGKKNIQYAVIKPIDSFNEV.......................................................................................................................................................................................................................... 163
16 -10.700[F] COG0232 dGTP triphosphohydrolase  ali follow..  14  60........................................................................................................................SEFQRDRDRIVHTTAFRRLKHKTQVFISPDGDHYRTR---LTHTIEVAQIARALARAL-KLDEDLAEGVALVHDFGH------------------FGHT--GEDALDAVLLPYGGFDHNAQSLRIVLVKHNGPLV--EIGSYASLEAQVAAIADDIAYNTHDIDDGLR.......................... 249
17 -10.500[J] COG0617 tRNA nucleotidyltransferase/poly(A) polymerase  ali follow..  12  60LARTERKSSAGYTGFICDFSPTITLEQDLIRRDLINAMAQSEDGEIIDPYGGKQDLENRILRSEDPLRV--RVARFAARYHSLGFKIASETLALMAELAQSGELQHLTAERIWLETEKALNEKNPEIYFETLHKTLFSEIDALYGVPNPVKHHPE--VDSFIHTMLVLKQAVNLTENNPILNKSAVRFAAICHDLGK-------ALTPQNILPHHYGHEQAGIKPTRSLCKRLKVPSYFQELAELTCEFHTHIHK-----AFELRAETVITLFNRFDV.................................... 334
18 -9.540[S] COG3111 Uncharacterized conserved protein  ali follow..  19  50..ESAKSLRDDTWV-----TLRGNIVERISDDLYV---FKDASGTINVDI-DHKRWNGVTVTPKDTVEIQGEVDKDWNSVEIDVKQIRKVNP.............................................................................................................................................................................................................................. 130
19 -9.510[R] COG4085 Predicted RNA-binding protein, contains TRAM domain  ali follow..  15  184..............EEVTIKGIITADQNAIGGGKLSTFLQDETGGIN--IYSPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNGIKINQSNQSLPAPKHLTINELINGSLGDQYEGRLVKLTAFVSSI-VTMIDDDHHAMTLRVMNETGVINELDEGKWYEFTGVLSRYQTF-QLLPRKSADLKLLEE............................................................................................................................ 367
20 -9.330[S] COG4339 Uncharacterized protein conserved in bacteria  ali follow..  14  24...................................................................................................................................................AEDRHYHN-----LAHIEAMLALAADHRALLS--DPQAVEAAIWFHDAIYDSKAK--------------DNEARSAALAAQKLASRTDPER-LDRIGAMILATATHQVPRFHDDAATRDASLFLDMDAFDAYERAVRREYGWVEEPMWRAGRGAVLKDFLARPRI.. 175
21 -9.320[R] KOG4757 Predicted telomere binding protein  ali follow..  11  14....LNQLKGGTIVNVYGVVKFFKPPYLSKGTDYSVVTIVDQTNVLTCLLFGNYEALPIIYKNGDIVRFHRKIQVYKKETQGITSSGFASLTFEGTLGAPIIPRTSSKYFNFTTEDHKMVEA-----LRVWASTHMSPSWTLLKLCDVQPMQYFDLTCQLLG-LLKVWDGTRTPFPSWRVLIQDLLTIDILVYD-------NHVHVARSLKVGSFL--------RIYSLHTKLQSMNSENQTMLSLEFHLHGGTSYGR-----------IRVLPESNSDVDQLKKDLES......................... 294
22 -9.190[L] KOG3108 Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit  ali follow..  9  36LPVTLASLSTEYSFRTIHTVGVILEKSYEDGK--TTYTLHDPEDTAKIFHAGGSKFVSPGLEEDTRVRLMGKLKNVAGNKMILIYYLQKLADNKEYE......................................................................................................................................................................................................................... 151
23 -9.080[T] COG1639 Predicted signal transduction protein  ali follow..  9  167VFDKRVRARRYSGLEEALAHILDNSEGAGLGLVIMMLMLKKEEDRTISRMVVPRNIEIQTQTTKLAASIADRIDDIPQLPSKLLEIQRAIENPDVTDLLKLVNSARFGMNKRCLDISEAVKRVGLRGLQNLLYSV---------GAGRVLQSTDDERKQLWNQAYRTGYFALGLAKATGQALIADSYICGLLHNLGEVEIQAERNIPPHVLDTIMSDHAEIGAALAQR---------NLPEPVINTIRFHHNLPHAPEEYKPL---ISTVAFANMTIRFLD................................. 472
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Damiano JS, Stehlik C, Pio F, Godzik A., Reed JC. CLAN, a novel human CED-4-like gene. Genomics. 2001 Jul;75(1-3):77-83.