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Query: [R] COG3596 Predicted GTPase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVMKNFEVLQPLQNSLSGLPLWVSERILQQINQLTHYEPVIGIMGKTGAGKSSLCNALFAGEVSPVSDVAACTRDPLRFRLQIGEHFMTIVDLPGVGESGVRDTEYAALYREQLPRLDLILWLIKADDRALATDEHFYRQVIGEAYRHKMLFVISQSDKAEPTSGGNILSTEQKQNISRKICLLHELFQPVHPVCAVSVRLQWGLRVMAERMIKCLPREPSSPVVALLQHPFRTWVAREQARDDFGETVDTILDTVSTFPLIPAPVRTIIQAVRSSVVSVARAVWDFFFLast
1 -89.300[R] COG3596 Predicted GTPase  ali  100  1MVMKNFEVLQPLQNSLSGLPLWVSERILQQINQLTHYEPVIGIMGKTGAGKSSLCNALFAGEVSPVSDVAACTRDPLRFRLQIGEHFMTIVDLPGVGESGVRDTEYAALYREQLPRLDLILWLIKADDRALATDEHFYRQVIGEAYRHKMLFVISQSDKAEPTSGGNILSTEQKQNISRKICLLHELFQPVHPVCAVSVRLQWGLRVMAERMIKCLPREPSSPVVALLQHPFRTWVAREQARDDFGETVDTILDTVSTFPLIPAPVRTIIQAVRSSVVSVARAVWDFFF 289
2 -52.000[R] COG0486 Predicted GTPase  ali follow..  17  185IDFPDEEIDFLADGKIEAHLNDIITQLDHKQGSILREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLREATDVERIGIVRAWSEIEQADRILLMLDSTEADNQDLEKVRSEFLTKPSNIPVTIVRNKADLSGENEGIVEQNGY--------------------TVITLSAKTQQGIALLREHLKQSM--GYQTNMEGGFLARRRHLEALEQAATHLQQGH-VQLTQFYAGELLAEELRRVQNHLSEITGQFSDDLLGNIF 458
3 -51.400[J] KOG1191 Mitochondrial GTPase  ali follow..  14  312LDFEDEMPIESVINKITSMSQDVESALDTNYDKLLQSGLQIAIVGRPNVGKSSLLNAWSKSERAIVTEVAGTTRDVVEANVTVRGVPITLLDTAGIRETNDVEKIGVERSETAAKVADVIIMAVSAVEGWTEEDTELLRKIQSDKLKQPMILVMNKIDCAPPGSCDQLEDQRKKEEVFH-------------KSVFTSAVTGQGIEELEDAILEILGLDRVPTGGHQWTVNQRQCEQLVRTKEALVRLR-EAIEDEIPIDFWTIELREAALSLAQISGQDVEEVLSSIF 606
4 -41.200[R] KOG2486 Predicted GTPase  ali follow..  20  136......................................PEFALVGRSNVGKSSLLNSLVRRKLALTSKKPGKTQCINHFRI---NDKWYLVDLPGYGELKQDWNKFTKDYFLNRSTLVSVFLLVDASIPVKPIDLEYASWL--GQNQVPMTLIFTKCDKRKKKKNG---GKKPEANIKEFQDLIQGFFETTPPWIMTSSVTNQGRDEILLHMAQLRNYWLKH................................................................... 318
5 -40.900[R] COG1160 Predicted GTPases  ali follow..  13  4......................................PVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGHAHIAGYDFIVIDTGGIDTEEGVEEKMAEQSLLAIDEADIVLFLVDARAGLTAADIGIANYLRQRQ-NKITVVVANKTD-----------------GIDADSHCAEFYQLGLGEIEQIAASQGRGVTQLMEQVLAPFAEKMENADENDRTSEERPNVGKSTLTNRILGEDRVVVFDMPGTTRDSIYIPMERDGQQYTLIDTAG....... 272
6 -39.600[R] COG1159 GTPase  ali follow..  16  11........................................IAIVGRPNVGKSTLLNKLLGQKISITSRKAQTTRHRIVGIHTEGPYQAIYVDTPGLEEKRAINRLMNKAASSSIGDVELVIFVVEGTRW-TPDDEMVLNKL--RDGKAPVILAVNKVDNVQE------------KVDLLPHLQFLASQMNFLDIVPISAETGMNVDTIAGIVRKHLPEAIHHFPEDYITDRSQRFMASEIIREKLMRFLGAEL.................................... 210
7 -39.200[R] COG1084 Predicted GTPase  ali follow..  18  152...........................LRNMPTVDLDAFTVVIAGFPNVGKSTLLRTLTGAE-PEVADYPFTTKGIQIGHLERKWKRIQVIDTPGLRPVEDMNNIELQAMVALENIADVIMFIFDASETCGYTLESQYSLYLGSVFDIPVVTVFNKMDLAENVK------------------YLEEYINMVEDPLKVSAFEGRGVSKIIKKLEGLYEKETREAHDN............................................................... 335
8 -32.700[R] COG0218 Predicted GTPase  ali follow..  21  26......................................PEIALAGRSNVGKSSFINTMLNRKLARTSGKPGKTQLLNFFNI---DDKMRFVDVPGYGYARVSKKEMIEEYLTTRENLRAVVSLVDLRHDPSADDVQMYEFL--KYYEIPVIIVATKADKIPRGKWNKHESAIKKK-----------NFDPSDDFILFSSVSKAGMDEAWDAILEKL......................................................................... 195
9 -32.200[E] COG4917 Ethanolamine utilization protein  ali follow..  16  3.......................................RIAFVGSVGAGKTTLFNALQGNYTLARKT-------------AVEFNDKGDIDTPGEYFN---HPRWYHALITTLQDVDMLIYVHGANDP----ESRLPAGLLDIGVSKRQIAVISKTDMPDAD--------------VAATRKLLLETGFEEPMFELNSHDPQSVQQLVDYLASLTKQEE..................................................................... 150
10 -29.800[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  13  140.......VLKRITPSLAYLEQIRQHM--ARLPSIDPNTRTVLICGYPNVGKSSFMNKVTRADVD-VQPYAFTTKSLFVGHTDYKYLRYQVIDTPGILDRPFEDRNIIEMALAHLRAAVLFFLDISGSCGYTIAQQALFHSIKSLFMNKPLVIVCNKTDLMPMENISEE-DRKLIEEMKSEAMKTAMGASEEQVLLKMSTLTDEGVMSVKNAACERLLDQRVE................................................................... 355
11 -26.900[O] KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis  ali follow..  10  42....NPELDRIATEDDLVEMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITN---PKAKCALLRDDLVLVDSPGTDVTTELD----SWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNEWLSKPNIFILNNRWDASASEPEYMEDVRRQHME--VEELKVANALEAQNRIFFVSAKEVQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQ--ILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKI. 398
12 -25.000[R] COG2262 GTPases  ali follow..  17  160LETDRRLLRNRIVQIQSRLERVEKQREQGRQSRIKADVPTVSLVGYTNAGKSTLFNRITEARVYAADQLFATLDPTLRRIDVADVGETVLADTVGIRHLPHDLVAAFKATLQETRQATLLLHVIDAADVRVQENIEAVNTVLEEAHEIPTLLVMNKIDMLEDFEPRIDRDEENKPI-----------------RVWLSAQTGAGIPQLFQALTERLSGE...................................................................... 364
13 -24.900[P] COG0370 Fe2+ transport system protein B  ali follow..  18  2....................................SQNTYCILGNPNTGKTSLFNALTGSYEY-VGNWSGVTVEKKVGTLR--SKTGKLIDLPGIYDNPISRDETVVTRFLLEEKFDCMLNIVDSSQ-----ERNLNLTVQLLEYGAPVVMGLNMIDVAA------------GRGIHLNIQNLAKKL----PILPVVARSGKGTEDILSTLSEKHVAPAI.................................................................... 166
14 -23.600[R] KOG0410 Predicted GTP binding protein  ali follow..  16  272IEVDKRILRTQIGVLKKELESVRKHRKQYRSRRVAIPVPVVSLVGYTNAGKSTLLNQLTGANV-LAENRLFATLDPTTRRVQMNGKEFLLTDTVGIQKLPTTLVAAFRATLEEIAESSLLVHVVDISHPLAEQQIEAVEKVMSEVSSIPKLVVWNKVDRVDDPQKVKLEAEETGDT------------------ICISALTGEGLDDFCNAVHEKLKDS...................................................................... 475
15 -23.400[R] COG1163 Predicted GTPase  ali follow..  14  25.....SFHLGQLKAKLAKLRRELLTSASSGSGG-RTGVASVGFVGFPSVGKSTLLSKLTGTE-SEAAEYEFTTLVTVPGVIRYKGAKIQMLDLPGIIDGAKDGRGRGKQVIAVARTCNLLFIILDVNKPLHHKQEKELEGVGIRLNKTPPDILIKKKEK.................................................................................................................................. 187
16 -23.300[T] KOG1487 GTP-binding protein DRG1 (ODN superfamily)  ali follow..  15  3...STLAKIAEIEAEMARTQKLLKARLAKLRRELITPKARIGFVGFPSVGKSTLLSNLAGVY-SEVAAYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLILIVLDVLKPLGHKKENELEGFGIRLNSKPPNIGFKKKDK.................................................................................................................................. 186
17 -23.000[U] KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1  ali follow..  17  18...................................QKEAKILFLGLDNAGKTTLLHMLKDERLVQHQPTQHPTSE----ELSIGKIKFKAFDLGG-------HQIARRVWKDYYAKVDAVVYLVDAYDRFAESKRELDALLSDEAATVPFLILGNKIDIPYAASEDELRYHLGLTNFTTGKGKVTLGDSGVRPVFMCSIVRKMGYGEGFKWLSQYIN........................................................................ 193
18 -22.600[T] KOG1486 GTP-binding protein DRG2 (ODN superfamily)  ali follow..  14  1..MGIIERIKEIEAEMARTQEYHLGQLKAKIAKLRTQ-GRVALIGFPSVGKSTLLTMLTGTH-SEAASYEFTTLTCIPGVIHYNDTKIQLLDLPGIIEGASEGKGRGRQVIAVAKSSDLVLMVLDASKSEGHRQTKELEAVGLRLNKTPPQIYFKKKKT.................................................................................................................................. 184
19 -22.400[R] KOG0074 GTP-binding ADP-ribosylation factor-like protein ARL3  ali follow..  14  15...................................DQEVRILLLGLDNAGKTTLLKQLASEDISHITPTQGFNIK----SVQSQGFKLNVWDIGG-------QRKIRPYWKNYFENTDILIYVIDSADRFEETGQELAELLEEEKSCVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRV-----------QIQSCSALTGEGVQDGMNWVCKNVNAKKK.................................................................... 182
20 -21.700[UZ] KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2  ali follow..  13  14...................................ERELRLLMLGLDNAGKTTILKKFNGEDIDTISPTLGFNIK----TLEHRGFKLNIWDVGG-------QKSLRSYWRNYFESTDGLIWVVDSADRMQDCQRELQSLLVEERAGATLLIFANKQDLPGALSSNAIREALELDSIRSHH-----------CIQGCSAVTGENLLPGIDWLLDDISSR...................................................................... 179
21 -21.400[U] KOG0072 GTP-binding ADP-ribosylation factor-like protein ARL1  ali follow..  16  15...................................SREMRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVE----QVTYKNLKFQVWDLGG-------QTSIRPYWRCYYSNTDAIIYVVDSADRIGISKDELLYMLREEEAGAILVVLANKQDMDGCMTVAEVHHALGLENLKNRT-----------QIFKTSATKGEGLDQAMDWLSNTLQSRK..................................................................... 181
22 -21.400[U] KOG0071 GTP-binding ADP-ribosylation factor Arf6 (dArf3)  ali follow..  13  19...................................NKEMRILMLGLDAAGKTTILYKLKLNQSVVTIPTVGFNVE----TVTYKNIKFNVWDVGG-------QDKIRPLWRHYFTGTKGLIFVVDSADRISEARQELHRIISDRERDCLLLVLANKQDLPGALSPAQITDVLQLDKLKDRL-----------NVQPTCALTGDGLLEGLAWLSQNAKLK...................................................................... 184
23 -21.300[U] KOG0070 GTP-binding ADP-ribosylation factor Arf1  ali follow..  13  15...................................KKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVE----TVEYKNISFTVWDVGG-------QDKIRPLWRHYFQNTQGLIFVVDSNDRVVEARDELHRMLNEDERDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRQRH-----------YIQSTCATSGEGLYEGLDWLSNNIASKA..................................................................... 181
24 -21.200[R] KOG0075 GTP-binding ADP-ribosylation factor-like protein  ali follow..  10  18...................................KEEMELTLVGLQFSGKTTFVNVISGQFAEDMIPTVGFNMR----KITRGNVTIKVWDIGG-------QPRFRSMWERYCRGVNAIVYMVDAADKLEASRNELHSLLDKPQAGIPVLVLGNKRDLPGALDETGLIERMNLSSIQDRE-----------CCYSISCKEKDNIDITLQWLIQHSKSQSR.................................................................... 186
25 -21.200[R] COG1100 GTPase SAR1 and related small G proteins  ali follow..  17  16...................................NKELRILILGLDGAGKTTILYRLQIGEVVTTKPTIGFNVE----TLSYKNLKLNVWDLGG-------QTSIRPYWRCYYADTAAVIFVVDSTDRMSTASKELHLMLQEEEQDAALLVFANKQDQPGALSASEVSKELNLVELKDRS-----------SIVASSAIKGEGITEGLDWLIDVIKEEQ..................................................................... 182
26 -21.100[R] KOG0395 Ras-related GTPase  ali follow..  15  21.......................................RMVVLGASRVGKSSIVSRFLNGR--FEDQYTPTIEDFHRKVYNIRGYQLDILDTSG-------NHPFPAMRRLSILTGDVFILVFSLDNRESFDEKRLQKQILEEAAELPMVICGNKNDHGELCRQVPTTEAELLVSGDENC-----------AYFEVSAKKNTNVDEMFYVLFSMA......................................................................... 190
27 -20.700[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  15  53...................................TKSNTVLLSGLSGSGKTVLFYQLRDGSSSMEPNEGTFVLHNENNTKKGKVKPVHLIDVPG-------HSRLISKLEEYLPRAAAVVFVVDALEFLPNIRADILTNASVIKNKTPVLLCCNKTDKVTAHTKEFIRKQMEKE.................................................................................................................. 197
28 -20.400[T] KOG3886 GTP-binding protein  ali follow..  15  42.......................................KVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATILDRIHSLQIGNLVLNLWDCGG--QDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDQSCLEAILQNSPDAKIFCLVHKMDLVQ--------EDQRDLIFKEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQL......................................................................... 241
29 -20.100[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali follow..  16  15...................................KEQYSILILGLDNAGKTTFLETLKKEYSLAFKALEKITVGQNVATIPVDSKQLKFWDVGG-------QESLRSMWSEYYSLCHGIIFIVDSSDRLDECSTTLQSVVMDEEEGVPILMLANKQDRQDRMEVQDIKEVFNKIAEHISARDSR--------VLPISALTGEGVKDAIEWMIVRLERNKKS................................................................... 192
30 -19.800[R] COG2229 Predicted GTPase  ali follow..  13  2....................................RENKIIFTGPVGVGKTTAIAAISDEALMTLDRKRNTTVAMDYGAISLDDTKVHLYGTPG-------QERFNFMWEILSQGSMGLVLLLDNARTNPLKDEFFLHSFRGLLEKAPVVVGITKMDIRSQPGIDVYHKYLAKHNLN-------------VPVFEIDARKEDDVKQLVSAMLFSIDPG...................................................................... 175
31 -19.800[R] KOG1673 Ras GTPases  ali follow..  11  103.......................................KISLLGDCQTGKTTFVVKYVGDENQSFLEMTGLNLMDKTFYVQGVTISFSIWDVGG------DEKRSKDHIPIACKDAVAILFMFDLTSRSTLNSFGWYSQARKWNKTAIPILIGTKFDDFVRLPPNLQWTIVTQARAYAKVMNA--------SLFFSSATHNINVNKIFKFILARL......................................................................... 266
32 -19.600[V] KOG1707 Predicted Ras related/Rac-GTP binding protein  ali follow..  13  3..........................MGVGDSSGSPKPIRIVVVGEKGSGKSSLIMAAARNTFH--PNIPSLLPYNLPSEFFPDRIPATVIDTSS-------RPEDKGKVVKEVRQADAIVLTFAFDRPETRLSKYWLPLFRQLEVRVPIIVAGYEVDNKE---------AYNHFSIEQITSALMKQYREVETSIQWSAQRLDQAKDVLYYAQKAV......................................................................... 177
33 -19.600[R] KOG1489 Predicted GTP-binding protein (ODN superfamily)  ali follow..  13  342........................................LGLIGLPNAGKSTILNKISNAK-PKIGHWQFTTLSPTIGTVSLGFDVFTVADIPGIIQGASLDKGMGLEFLRHIERSNGWVFVLDLSNKNPLNDLQLLIETLEKVKTKNILIVCNKVDIDAEKSESFAKYLQVEKFSKSQ-----------WDCVPISALREKT..................................................................................... 499
34 -19.600[U] KOG3887 Predicted small GTPase involved in nuclear protein import  ali follow..  12  60...................................EVKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKICREDVSNSSVNFQIWDFPG----QIDFFDPTFDYEMIFRGTGALIFVIDSQDDYMEALARLHLTVTKVNTDINFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKIH----SFYLTSIYDHSIFEAFSKVVQKL......................................................................... 237
35 -19.500[J] KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  14  39...................................QATINIGTIGHVAHGKSTVVKAISGVHTVRFKN-ECYRSCGSSMPDEFLVRHVSFVDCPG-------HDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKERQAKEQYEQILA--------FVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPR.................................................................... 248
36 -19.500[U] KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily  ali follow..  12  1..........................MSAPAANGEVPTFKLVLVGDGGTGKTTFVKRHLTGEEKKYIATIGVEVHPLSFYTNFGEIKFDVWDTAG-------QEKFGGLRDGYYINAQCAIIMFDVTSRITYKNPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNL---------------QYYDISAKSNYNFEKPFLWLARKLAGNPQLEFVASPALAPPEVQVDEQLMQQYQQEMEQATALPLPDE............................. 214
37 -19.200[R] KOG0393 Ras-related small GTPase, Rho type  ali follow..  13  2....................................QAIKCVVVGDGAVGKTCLLLSYTTN--AFPGEYILTVFDTYSTNVMVDGINLSLWDTAG-------QDDYDQFRHLSFPQTDVFLFALNNPASFENVRAKWYPEVSHHCPNTPIILVGTKADLREDRDTIERLRESRLQPVSHTQGYVMAKEIKAVKYLECSALTQIGLKQVFDEAIRTG......................................................................... 176
38 -19.200[R] COG0536 Predicted GTPase  ali follow..  15  162........................................VGLVGFPSAGKSSLISVMSAAK-PKIGDYPFTTLQPNLGVVNVGHETFTMADVPGLIPGASEGKGLGLDFLRHIERTSVLVHVVDTATMDPGRDEALEAELAAYQSQRPRLVVLNKADVPEAEELAEFLKEDIEKQ-------------FGWPVFIISAVARKGLDPLKYKLLEIVQDARKKRPKEKAESV.......................................................... 355
39 -18.700[TU] KOG1954 Endocytosis/signaling protein EHD1  ali follow..  19  47...KNKEVLETVSEGLRKIYKQKLLPLEEFHDPDFDAKPMILLVGQYSTGKTTFIRYLLESDFPGIRIGPEPTTDRFIAVMHGDEESVTIVDTPGIKQRIDRGYDFTGVLEWFAERVDRIILLFDAHKLDISDEKRCIEAL--AGNEDKIRIVLNKSDMVDHQQ............................................................................................................................. 262
40 -18.200[R] KOG2485 Conserved ATP/GTP binding protein  ali follow..  17  118............RSSVMKLLDLVELKLKEV--IAREPTLLVMVVGVPNVGKSALINSIHQLKRATVGPLPGVTQDIAGFKIA-HRPSIYVLDSPGVLVPSIPD-----------IETGLKLALSGSVKDSVVGEERIAQYFL................................................................................................................................................... 244
41 -17.800[J] KOG0460 Mitochondrial translation elongation factor Tu  ali follow..  14  39.......................RTYADEKVFVRKKPHVNIGTIGHVDHGKTTLTAAITK-DKAPEEKARGITISSAHVEYETANRHYAHVDCPG-------HADYIKNMITGAATMDGAIIVVSATDGQMPQTREHL-LLARQVGVKQIVVYINKVDMVEPDMIELVEMEMR--------ELLSEYGFDGDNTPIVSGSALCALEGREPEI............................................................................. 226
42 -17.800[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  13  1..................................MKRPLIIGVGGPVGAGKTMLIERLTGYSMAAITNDIYTKEDIEEMCDKHPDLQLLFLESGGDNLSATFSPDL----------VDFSIYIIDVAQG------EKIPRKGGQGMIKSDLFIINKVDLAPYVGANVEVMKADTLKSRGNK-----------DFFVTNLKTDEGLKSVADWIEKRL......................................................................... 199
43 -17.500[J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  12  4...................................QSEINIGLVGHVDHGKTTLTKALSGTKRGISIRLTTAEICERCGTETELLRKVSFVDAPG-------HETLMATMLSGAALMDGAILVIAANEPCPQPQTKEHLMALDVIGVKDVIVVQNKIDIVSKERALESYREIKE--------FVKGTCAEDAPIIPVSAQQGANIDILIETIEERIKTPKR.................................................................... 202
44 -17.100[J] COG0050 GTPases - translation elongation factors  ali follow..  14  1..........................MSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITT-DNAPEEKARGITINTSHVEYDTPARHYAHVDCPG-------HADYVKNMITGAAQMDGAILVVAATDGPMPQTREHI-LLGRQVGVPYIIVFMNKCDMVDDEELLELVEMEVRE-------LLSAYDFPGDDLPVVRGSALKALEGEAEWEAK........................................................................... 188
45 -17.100[P] COG2895 GTPases - Sulfate adenylate transferase subunit 1  ali follow..  13  1...........MNTALAQQIANEGGVEAWMIAQQHKSLLRFLTCGSVDDGKSTLIGRLLHDTRQIYEDQQGITIDVAYRYFSTEKRKFIIADTPG-------HEQYTRNMATGASTCELAILLIDARKGVLDQTRR--SFISTLLGIKHLVVAINKMDLVDYSEETFTRIREDYLTFAGQLP-----GNLDIRFVPLSALEGDNVASQSESM............................................................................. 220
46 -16.800[J] KOG1145 Mitochondrial translation initiation factor 2 (IF-2; GTPase)  ali follow..  17  144.KAGMKLKWSKLKQDKVRKNKDAVRRPQADPALLTPRSPVVTIMGHVDHGKTTLLDKFRKTQVA-AVETGGITQHIGAFLVSLSGEKITFLDTPG-------HAAFSAMRARGAQVTDIVVLVVAADDGVMKQTVESIQH--AKDAQVPIILAVNKCDKAEA-------DPEKVKKELLAYDVVCEDYGGDVQAVPVSALTGDNLMALAEATV............................................................................ 339
47 -16.700[M] COG0481 Membrane GTPase LepA  ali follow..  13  6.......................................NFSIIAHIDHGKSTLSDRLIQTCGGLLERERGITIKAQSVTLNYETYQLNFIDTPG-------HVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAIEMNL--EVVPILNKIDLPAADPERVAEEIEDIVGIDAM------------EAVRCSAKTGVGIEDVLEEIVHKIP........................................................................ 181
48 -16.500[T] KOG4252 GTP-binding protein  ali follow..  11  11.......................................KMVVVGNGAVGKSSMIQRYCKGITKDYKKTIGVDFLERQIQVNDEDVRLMLWDTAG-------QEEFDAITKAYYRGAQACVLVFSTTDRGSFEASSWREKVVAEVGDIPTVLVQNKIDLLDDSCIKNEEAEALAKRLR--------------RFYRTSVKEDLNVNEVFKYLAEKYLQKLKQQIAE............................................................... 179
49 -16.500[J] KOG0462 Elongation factor-type GTP-binding protein  ali follow..  16  44.......................................NFGIVAHVDHGKSTLADRLLEMDKLQVERERGITVKAQTAALRHRGYLLNLIDTPG-------HVDFSAEVSRSLAVCDGILLLVAANQGVQAQTIANFWLAFEKNI--QIIPVINKIDLPGADIKSVETQLKNLFEFNPE------------ECLHISAKSGLNVDKVLEAIIDRVP........................................................................ 212
50 -16.200[J] KOG0052 Translation elongation factor EF-1 alpha/Tu  ali follow..  13  5...................................KVHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTRGITIDIALWKFETAKYYITIIDAPG-------HRDFIKNMITGTSQADCAVLVVACGTGEFEAGISKNGQTREHAL-KQLIVACNKMDSTEPP------SEARFTEITNEVSGFIKKIPKAVPFVPISGFNGDNMLEVSSNM............................................................................. 208
51 -16.100[U] KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases  ali follow..  12  22.......................................KLVLLGESAVGKSSLVLRFVKGQHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAG-------QERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALNKADLANKRAVDFQEAQSYADDNSLL-------------FMETSAKTSMNVNEIFMAIAKKLPKNEPQ................................................................... 187
52 -16.100[R] KOG0394 Ras-related GTPase  ali follow..  11  10.......................................KVIILGDSGVGKTSLMNQYVNKKSNQYKATIGADFLTKEVQFEDRLFTLQIWDTAG-------QERFQSLGVAFYRGADCCVLVYDVNSMKSFENLNNWREEFLIQASPSFVLIGNKVDV----------DDGNSRVVSEKKAKAWCASKGNIPYFETSAKVGTNVEEAFQCIAKDALKSGEE................................................................... 182
53 -16.100[J] COG5256 Translation elongation factor EF-1alpha (GTPase)  ali follow..  12  8...................................KPHLNLITIGHVDHGKSTLVGRLLYEHGEIPAHIRGVTIDLAHRKFETDKYYFTLIDAPG-------HRDFVKNMITGTSQADAAILVISAREGEGVMEQTREHAFLARTLGPQMVVAINKMDATSPPYSEKRYNEVKAD----AEKLLRSIGFKDISFVPISGYKGDNVTKPSPNM............................................................................. 204
54 -16.100[J] COG3276 Selenocysteine-specific translation elongation factor  ali follow..  13  1......................................MIIVTSGHVDHGKTALLKALTGTSTAHLPEEKGMTIDLGYAYLPLENKVLGFIDVPG-------HEKFLSNMLAGLGGVHYAMLIVAADEGVAVQTKEHLA-ILRQLQFHEIIVVITKADRTNS----------AQIESLIQTIKQDYSFLRNANYFVTSAETGQGISELRHYLANLAELADTQ................................................................... 168
55 -16.100[J] KOG0469 Elongation factor 2  ali follow..  15  1...............MVNFTVDEIRALMDRKRNIRN----MSVIAHVDHGKSTLTDSLVSKAGIIAGSKAGETRDTRKDEQE-NGFLINLIDSPG-------HVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERI--KPVLFMNKMDRA................................................................................................................................. 175
56 -15.900[U] KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily  ali follow..  9  11.......................................KLVFLGDQSVGKTSIITRFMYDKDTTYQATIGIDFLSKTMYLEDRTVRLQLWDTAG-------QERFRSLIPSYIRDSSVAVVVYDVANRLSFLNTSKWIEEVRNERAGDVIIVLNKTDLVEKRQVSIEEGDSKGREYGVM-------------FIETSAKAGFNIKPLFRKIAAALPGMESYSNTKN.............................................................. 181
57 -15.900[J] COG0012 Predicted GTPase, probable translation factor  ali follow..  11  1......................................MEIGVVGKPNVGKSTFFSAATLVD-VEIANYPFTTIDANVGVTYA--IPVKMIDVAGLVPGAHEGRGLGNKFLDDLRMASALIHVVDVEREIDYWIYGILSKGWDKFAKKPMIIAANKADAASEEQINRLIKEGEKRG---------------YIVVPTSAAAELTLRKAAKAFIDYIPGSSEFKILKDMN---------ERQKKALLMIKEKVLDRFGSTGVQEVINKAVFELLNLIPVYPVQD...... 327
58 -15.700[R] KOG0088 GTPase Rab21, small G protein superfamily  ali follow..  13  1..........................MLETNVDQKSFKFKIVLLGEGCVGKSSLVLRFVENKSCKHLSTIQASFQNKTVNVEDCQADLHIWDTAG-------QEKYHALGPIYYRGSNGVLLVFDITDRKSFEKVKNWVLEIKTCLGNTAEILINKIDLEEERQVTRQDAEAYAESEGAL-------------YMETSAQDNVGISDAFESLTAKMIEHSRT................................................................... 179
59 -15.700[R] KOG0083 GTPase Rab26/Rab37, small G protein superfamily  ali follow..  12  470.......................................KVIMLGDSGVGKTSLLIRFRDGRYVPSYFLSTVGIDFRNKVVVVDGTRVKL-DTAG-------QERFRSVTHAYYRDAHALLLLYDVTNKTTYDNIRAWLGEIREYAQEDVVIVLNKADCSGSERQ---VKREDGERLGREHNVP---------FMETSAKTGLNVELSFTAVARQLKSRGYEHGDD............................................................... 641
60 -15.700[R] KOG0079 GTP-binding protein H-ray, small G protein superfamily  ali follow..  9  12.......................................KLLIIGDSGVGKSSLLLRFADNTSENYITTIGVDFKIRTMDINGQRVKLQIWDTAG-------QERFRTITSTYYRGTHGVVVVYDVTNGESFGNKRWLQEIENNCDSVQKVLVGNKCEENERRVVLESDARNYAQSMN--------------SFFETSAKEDKNVEPMFTCITSLVLTA...................................................................... 173
61 -15.600[R] KOG2203 GTP-binding protein  ali follow..  16  42.......................................VVAIMGPQSSGKSTLLNHLFKTSFREMDAFAGTTKGIWMARCVGIEPFTIAMDLEGTDGRERGEDDTTQSALFAIAVADIVLINMWCHDREQAANKPLLKTVFQSPRKTTLLFVIRDKTKTPIELLERALREDIQKIWDSVRKPEAHKNTPLNEFFNVGVVPASGFSFSSQQIWKVIKENRDLPAHKVMVATVRCEEIANEKLRDLATNESWLELHEAAEGGLVPGFGKKLSSILEKYFSEYDA...... 341
62 -15.500[J] COG4108 Peptide chain release factor RF-3  ali follow..  8  17.......................................TFAIISHPDAGKTTITEKVLGSNQHAKSD-RGISVTTSVMQFPYGDCLVNLLDTPG-------HEDFSEDTYRTLTAVDSCLMVIDAAKGVEDRTRKLMEVT--RLRDTPIVTFMNKLDR-------------EIRDPMELMDEVENELKIACSPITWPIGCGKEFKGVYHIHRDETILYTSGQGHTIQEERIIKGLDNPELDQAVGADLAAQL.................................... 229
63 -15.500[R] COG1161 Predicted GTPases  ali follow..  19  159...............TSAQNKDDVAELMEAIEYY-RRGRDVYVVGVTNVGKSTLINAIIKSDVITTSRFPGTTLDKIEIPL---DEDSALIDTPGIIHRGQIAHYLEPEDLKYVSPRKEI......................................................................................................................................................................... 264
64 -15.500[DZU] KOG2655 Septin family protein (P-loop GTPase)  ali follow..  18  18...............FANLPNQVHRKSVKK-------EFTLMVVGESGLGKSTLVNSLFLTDLYPERIIPDAIEEASTVEIEERGVKLTVVDTPGFGDAIDNSRDESGLNRRNIVDNRIFYFISPFGHGLKPLDVEFMKKLHSK----NIVPVIAKADCLTKKE............................................................................................................................. 189
65 -15.400[T] COG1217 Predicted membrane GTPase involved in stress response  ali follow..  14  1.................................MIENLRNIAIIAHVDHGKTTLVDKLLKLDSNDQEKERGITILAKNTAIKWNGYNINIVDTPG-------HADFGGEVERVMSMVDSVLLVVDAQDGPMPQTRFVTQKAFKAGL--RPIVVVNKIDR.................................................................................................................................. 132
66 -15.400[DZ] COG5019 Septin family protein  ali follow..  16  78...............FASLPNQWHRRCVRQ-------NFNVLVLGESGSGKSTLVNTLLNRDVEPTVMINSSAVEIVENGISLQ---LNVIDTPGFGDFIDELEKHNPRSTIQDPRVHACIFFIQPTHAISAMELRVMLALHEK----NIIPIIAKADTLTDDE............................................................................................................................. 252
67 -15.300[J] KOG0468 U5 snRNP-specific protein  ali follow..  14  133.......................................NVALVGHLHHGKTTFVDCLIEQERGCSIKATPVT--LVLQDVKQKSYLLNIFDTPG-------HVNFSDEATAAMRMSDGVVLFIDAAEGVMLNTERLLKHAVQERQ--AITVCINKIDRL................................................................................................................................. 265
68 -15.300[E] COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family  ali follow..  15  37....................QALSTQLLDAIMPYCGNTLRLGVTGTPGAGKSTFLEAFGGLKVAVIAGASQRARELML-LCEAAGYDVVIVETVGVGQSE-----------EVARMVDCFISLQIAGGG------DDLQGIKKGLMEVADLIVINKDDG----DNHTNVAIARHMYESALHILRRKYDEWQPRVLTCSALEKRGIDEIWHAIIDFK----TALTASGRLQQVRQQQSVEWLRKQTEEEVLNHLFANEDFDRYYRQTLLAVKNNTLSPRTGLRQLSEFIQ 326
69 -15.200[R] KOG1491 Predicted GTP-binding protein (ODN superfamily)  ali follow..  17  1..................MPPKKQVEEKKVLLGRPGNNLKAGIVGLANVGKSTFFQAITRCPLGNPANYPFATIDPEEARVIVPSAHLTVYDIAGLTKGASAGEGLGNAFLSHIRSVDSIYQVVRCFDDAEIIHVE-LEIINQELRLKDIEFAQKALEGAEKIAKRGGQSLEVKQ.................................................................................................................. 182
70 -15.000[R] KOG0080 GTPase Rab18, small G protein superfamily  ali follow..  13  10.......................................KILIIGESGVGKSSLLLRFTDDTDPELAATIGVDFKVKTISVDGNKAKLAIWDTAG-------QERFRTLTPSYYRGAQGVILVYDVTRRDTFVKDNWLNELETYCTRNDIVNMLNKIDKENREVDRNEGLKFARKH---------------MLFIEASAKTCDGVQCAFEELVEKIIQTPG.................................................................... 174
71 -15.000[U] KOG0095 GTPase Rab30, small G protein superfamily  ali follow..  12  11.......................................KIVLIGNAGVGKTCLVRRFTQGLPPGQGATIGVGFMIKTVEINGEKVKLQIWDTAG-------QERFRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYASNKVITVLNKIDLAERREVSQQRAEEFSEAQD--------------YYLETSAKESDNVEKLFLDLACRLISEARQ................................................................... 176
72 -14.900[R] COG5258 GTPase  ali follow..  13  95.........................LLRAVSREEPPPTVTVVALGNVDAGKSTLVGVLTTGR---LDDGKGLARSYAAEVYKRSDKLVLLVDVGG-------HERYLRTALRGLSQPDYVMLVVAANSGVQKMTKEHLGIAVA--IGIPVFVVVTRIDITPSEVFQKTVEEVVRDTNDVVLAAKAMPAGRVAPVFYVSSVTGHGLDLLLRFL............................................................................. 324
73 -14.800[U] KOG0093 GTPase Rab3, small G protein superfamily  ali follow..  9  24.......................................KILIIGNSSVGKTSFLFRYADDSTPAFVSTVGIDFKVKTIYRNDKRIKLQIWDTAG-------QERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVLLNKCDMEDERVVSSERGRQLADHLG--------------EFFEASAKDNINVKQTFERLVDVICEKMSESLDT............................................................... 193
74 -14.800[TU] KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins  ali follow..  9  11.......................................KLLLIGDSGVGKSCLLLRFSEDSTPSFITTIGIDFKIRTIELDGKRIKLQIWDTAG-------QERFRTITTAYYRGAMGILLLYDVTDKKSFDNVRTWFSNVEQHASENVYKILNKCDCEDQRQVSFEQGQALADELG--------------KFLEASAKTNVNVDEAFFTLAREIKKQKIDAENE............................................................... 180
75 -14.700[TU] KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins  ali follow..  10  10.......................................KLLLIGDSGVGKSCLLLRFADDSLDSYISTIGVDFKIRTVEQDGKTIKLQIWDTAG-------QERFRTITSSYYRGAHGIIVTYDVTDLESFNNVKQWLNEIDRYASENVNKLLNKCDLTSQKVVSTETAKAFADELG--------------PFLETSAKNATNVEEAFMAMTAAIKTRMAS................................................................... 175
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.