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Query: [R] COG3687 Predicted metal-dependent hydrolase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRCCAMALLMPPVASRPTRARRRIRHGEADIVGCRGAVNVEVHSAPGWRAGSSPLGYAQLYLPTRDVYWGDMSGIYVNAVATFSEGAAMVSVDDRATGPHSSESRAADHERLVLEPRDVEFDWTNLPFHYVPNEPMATHVLNVLHMLLPAGEEFFVRVFKKTLPLIKDDQLRLDVQGFIGQEAMHSQAHSGVVDHFDAQGVDVTAFTNQIRWLFEKLLGESPRRSPRRQYSWLLEQVSFIAAIEHYTAVMGEWILNSPQLDAVGADPVMLDMLRWHGAEEVEHKAVAFDTMKHLRAGYWRQVRAQLTVTPVMLLLWIRGVRFMYSVDPYLPPGTKPRWRDYFKAARRGLVPGLPRLLRVVGHYYKPGFHPSQLGGLGAAVDYLAVSPAARASHLast
1 -154.000[R] COG3687 Predicted metal-dependent hydrolase  ali  100  1MRCCAMALLMPPVASRPTRARRRIRHGEADIVGCRGAVNVEVHSAPGWRAGSSPLGYAQLYLPTRDVYWGDMSGIYVNAVATFSEGAAMVSVDDRATGPHSSESRAADHERLVLEPRDVEFDWTNLPFHYVPNEPMATHVLNVLHMLLPAGEEFFVRVFKKTLPLIKDDQLRLDVQGFIGQEAMHSQAHSGVVDHFDAQGVDVTAFTNQIRWLFEKLLGESPRRSPRRQYSWLLEQVSFIAAIEHYTAVMGEWILNSPQLDAVGADPVMLDMLRWHGAEEVEHKAVAFDTMKHLRAGYWRQVRAQLTVTPVMLLLWIRGVRFMYSVDPYLPPGTKPRWRDYFKAARRGLVPGLPRLLRVVGHYYKPGFHPSQLGGLGAAVDYLAVSPAARASH 393
2 -13.400[S] COG1633 Uncharacterized conserved protein  ali follow..  9  29.......................................................................................................................................................EKEAREFYLQQAGLMENPKFKELYEELAAEEMKHLGYLENYRDKKELP----EISTEVPSGQSFSPEFDASRTKVGEITLGDAGILLAAMRHERKSEDFYSEMAKRVE------DETQKKFFEMLSRYERGHYEVIDSYLEYI................................................................................................... 161
3 -10.800[F] KOG1567 Ribonucleotide reductase, beta subunit  ali follow..  14  1........................................................................MGDPERPEAAGLDQDERSSSDTNESEIKSNEEPLLRKSSRRFVIFPIQYPDQAQASFWTAEEVDLSKDLPHWNKLKADEKYFISHILARFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADALRWIADRKSTFGERVVAFAAVEGVFFSGSFAAI---WLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQYL................................................................................................... 242
4 -9.620[S] COG2833 Uncharacterized protein conserved in bacteria  ali follow..  9  13......................................................................GNAIRAISACDLDEKVRLARETASRWFARALSVRSPLDPPLPERPGRPEKPELRMLKKRSLNTEHGRIALMHALAHIELNAIDLALDIVARFAVKPIPRSFFDGWMKVADDEARHFTL---LRNRLKSLGADYGDMPAHDGLWQSAHQTRND----------EARLAVVPLILEARGLDVTPSLLEK---MIETGDHETAAILNIIYNDEKTHVAVGAKWFRFF................................................................................................... 224
5 -9.250[R] COG2406 Protein distantly related to bacterial ferritins  ali follow..  12  14..................................................................................................................................VDVDKLLELLIKNAAAELTTYYYYT--ILRANLIGLEGETIKEIAEVARIEDRNHF---EALVPRIYELGGKLPDCMKEFHDLSA-------PPARLPDKPTVQEILRVLVAAERCAVKGYTEICN----MTAGKDHRTYELSLAILNEEIEHESWFSEFLGEGPSGHFMR............................................................................................ 169
6 -9.080[S] COG4902 Uncharacterized protein conserved in archaea  ali follow..  12  43....................................................................................................................................YAPLSDEEANSLLYMIEE-EKLARDVYLKLYNETGLIIFDR----IAQSEQRHMDA---VLMLIEKYNLTAPDTLNEIGVFENEELQNLYNELVEMGSQSVVDALKVGALIEEIDIKDLEEWLSKVD------NEDIKVVFENLMDGSKNHLRAFTKVLADNYGIEY.............................................................................................. 195
7 -9.050[F] COG0208 Ribonucleotide reductase, beta subunit  ali follow..  11  2............................................................................LRQEAKRMKATMAYSTFTQKKNDQLKEPMFLGQPVNVARYDQQKYEIKQLSFFWRPEEVDVSSDRIDYGKLPDHEKHIFISNLKALLPLVSLPELETWIETWSFSETIHSRSYTHIIRNIVNDPAVVEHIIKRAKDIAHYYDDLIELTNDYHLKKKLYLCLMSVNALEAIRFYVSFACS---AFAERELMEGNAKIIKLIARDEALHLTGTQHMLNLL................................................................................................... 265
8 -8.650[P] COG3546 Mn-containing catalase  ali follow..  11  8........LQYTVVSEPNPGLANL------LLEQFGGPQGELAAACRYFTQGLSDDDAGRRIATEELSHLEIIGSLVGMLNKGAKGELAEGTENEAELYRSLTQNGNDSHITSLLYGGGPALTNSGGVPWTAAYIDTIGEVTADLRSNIAAEARAKIIYERLINLTDDPGVKDTLSFLMTREVAHQLSFEKALYSIRNN.................................................................................................................................................................................................. 198
9 -8.440[S] COG3461 Uncharacterized conserved protein  ali follow..  9  1......................................................................................................................MADQYHEPVSELTGKDRDFVRALNSLK-----EEIEAVAWYHQRVVTTKDETVRKILEHNRDEEMEHAAM---LLEWLRRNMPGWDEALRTYLFTDKPITEIEEETSGGSENTGGDLGIR........................................................................................................................................................... 112
10 -7.570[P] COG2193 Bacterioferritin (cytochrome b1)  ali follow..  13  4....................................................................................................................................DTKVIERLNEALFLELGAVNQYWLHYR--LLNDWGFTKLAKKERAESIEEMQHA---DKIIDRIIFLE-----------------HPNLQTLAPLRIGQNVKEVLEADLAGEYDARTSYKKSRD---ICSEAGDYVSMKLFEALLIDEEGHIDFLETQLELL................................................................................................... 141
FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 4 6 8   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.