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Query: [I] COG3890 Phosphomevalonate kinase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSELRAFSAPGKALLAGGYLVLDTKYEAFVVGLSARMHAVAHPYGSLQGSDKFEVRVKSKQFKDGEWLYHISPKSGFIPVSIGGSKNPFIEKVIANVFSYFKPNMDDYCNRNLFVIDIFSDDAYHSQEDSVTEHRGNRRLSFHSHRIEEVPKTGLGSSAGLVTVLTTALASFFVSDLENNVDKYREVIHNLAQVAHCQAQGKIGSGFDVAAAAYGSIRYRRFPPALISNLPDIGSATYGSKLAHLVDEEDWNITIKSNHLPSGLTLWMGDIKNGSETVKLVQKVKNWYDSHMPESLKIYTELDHANSRFMDGLSKLDRLHETHDDYSDQIFESLERNDCTCQKYPEITEVRDAVATIRRSFRKITKESGADIEPPVQTSLLDDCQTLKGVLTCLIPGAGGYDAIAVITKQDVDLRAQTANDKRFSKVQWLDVTQADWGVRKEKDPETYLDKLast
1 -126.000[I] KOG4519 Phosphomevalonate kinase  ali follow..  100  1MSELRAFSAPGKALLAGGYLVLDTKYEAFVVGLSARMHAVAHPYGSLQGSDKFEVRVKSKQFKDGEWLYHISPKSGFIPVSIGGSKNPFIEKVIANVFSYFKPNMDDYCNRNLFVIDIFSDDAYHSQEDSVTEHRGNRRLSFHSHRIEEVPKTGLGSSAGLVTVLTTALASFFVSDLENNVDKYREVIHNLAQVAHCQAQGKIGSGFDVAAAAYGSIRYRRFPPALISNLPDIGSATYGSKLAHLVDEEDWNITIKSNHLPSGLTLWMGDIKNGSETVKLVQKVKNWYDSHMPESLKIYTELDHANSRFMDGLSKLDRLHETHDDYSDQIFESLERNDCTCQKYPEITEVRDAVATIRRSFRKITKESGADIEPPVQTSLLDDCQTLKGVLTCLIPGAGGYDAIAVITKQDVDLRAQTANDKRFSKVQWLDVTQADWGVRKEKDPETYLDK 451
2 -126.000[I] COG3890 Phosphomevalonate kinase  ali  100  1MSELRAFSAPGKALLAGGYLVLDTKYEAFVVGLSARMHAVAHPYGSLQGSDKFEVRVKSKQFKDGEWLYHISPKSGFIPVSIGGSKNPFIEKVIANVFSYFKPNMDDYCNRNLFVIDIFSDDAYHSQEDSVTEHRGNRRLSFHSHRIEEVPKTGLGSSAGLVTVLTTALASFFVSDLENNVDKYREVIHNLAQVAHCQAQGKIGSGFDVAAAAYGSIRYRRFPPALISNLPDIGSATYGSKLAHLVDEEDWNITIKSNHLPSGLTLWMGDIKNGSETVKLVQKVKNWYDSHMPESLKIYTELDHANSRFMDGLSKLDRLHETHDDYSDQIFESLERNDCTCQKYPEITEVRDAVATIRRSFRKITKESGADIEPPVQTSLLDDCQTLKGVLTCLIPGAGGYDAIAVITKQDVDLRAQTANDKRFSKVQWLDVTQADWGVRKEKDPETYLDK 451
3 -59.900[I] KOG1511 Mevalonate kinase MVK/ERG12  ali follow..  16  1MSKSLIVSSPGKTILFGEHAVVY-GATALAAAVSLRSYCKLQTTNNN------EIVIVMSDIGT----------ERRWNLQSLPWQHVTVENVQHPASSPNLDLLQGLGELLKNEENGLIHSAMLCTLYLFTSLSSPSQGCTLTISSQVPLGAGLGSSATISVVVATSLLLAFGNIEPPQNNKALALIEAWSFLGECCIHGT-PSGIDNAVATNGGLIAFRK------------------------ATAHQSAMKEFLKPKDTLSVMITDTKQPKSTKKLVQGVFELKERLPTVIDSIIDAIDGISKSAVLALTS------------------------ESDKNSSAKKLGEFIVLNQKLLECLG------VSHYSIDRVLQATKSIGW---TKLTGAGGGGCTITLLTPEEEEFKLCKESLLAHKNSIYDVQLGGPGVSVVTDSDSFFPQ 383
4 -40.200[I] COG1577 Mevalonate kinase  ali follow..  16  58............................................................................................................................................LAVTIQTNLPPSRGLGSSAAVAVAFVRASYDFLG------KSLTKEELIEKANWAEQIAHGK-PSGIDTQTIVSGKPVWFQK-----------------------------GHAETLKTLSLDGYMVVIDTGVKGSTRQAVEDVHKLCEDPQ--YMSHVKHIGKLVLRASDVIEH-----------------------------HNFEALADIFNECHADLKALT------VSHDKIEQLMKIGKEN-GAIAGKLTGAGRGGSMLLLA-KDLPTAKNIVKAVEKAG......................... 268
5 -39.300[R] COG2605 Predicted kinase related to galactokinase and mevalonate kinase  ali follow..  13  1...MLISRAPVRISFFGGGTFLQHGGAVLATAIDKFSYVTASPFLSHLFDYSIRVSYRK--------------------VELVKNPSEMEHVVFRECLKFCGLEKD----------------------------------IELHNVADLPAFTGLGSSSAFTVSLLQALHSFKG------EFIRPLDLAYEAIYVERHLVKDKVGCQDQLMAAMGGFNLVEFRKED-------------------------DIVVSRVTMAPERHIFIVFTGIKRRAANVVEKQLKRVGDNRE----TLKLMRAMVDKGWDILTS----------------------------NQCLSAFGELLDQAWQAKRSLDV----GISNGDIDRIYQQGRE-AGAWGGKLLGAGAGGFMLFFA--PPSVHPRLAETFKDHQV--LSVKINAPGSQI.......... 323
6 -34.900[R] COG1829 Predicted archaeal kinase (sugar kinase superfamily)  ali follow..  11  1ML--VRAFVPAHITAFFVPIIQLSGSLGAGVNLSRGTNVFISFEESLERHVHVALN-----------------------EPVKREDAKVTFHVIDKMLPQEYVGE-----------------------------------VEVWQYFDYPTGHGFGNSGGGALGTALCLAYKFR--------RTLLSAAKVAHEAEVLNRGGLG---DIVAQLAGGVEVRIKEGGPGVAIVD--------------------------NLIVEGFKVLTISLGRLSTREVLD-------------SDVVEKIKVEGQKSLENLLANP-------------------------------TLETLMREARRFAEVTG------LMDDELKEIAREVDKV-ISLPSSMIMLGK--GIFAMV--RNEEVERVKELVKDLGVPYDIAEIYWGKPTVGR........ 296
7 -30.800[G] COG0153 Galactokinase  ali follow..  13  18.PATHTIQAPGRVNLIGEHTDYNDGF-VLPCAIDYQTVISCAPRDDR------KVRVMAADYENQLDEFSLDAP---IVAHENYQWANYVRGVVKHLQL----------------------------------RNNSFGGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHL------PLDGAQIALNGQEAENQFVGCNCGIMDQLISALG-------------------------KKDHALLIDCRSLGTKAVSMPKGVAVVIINSNFKRT---LVGSEYNTRREQCETGARFFPALRDVTIEEFNAVAHELDPIVAKRVRHILTENARTVEAASALEQGDLKRMGELMAESHASMRD-----DFEITVPQIDTLVEIVKAVGDKGGVRMTGGGFGGCIVALIPEEPAVQQAVAEQYEAKT-ETFYVCKPSQGAGQ.......... 381
8 -22.500[R] COG1907 Predicted archaeal sugar kinases  ali follow..  11  1...MLRLRTPSRIHIT---GSIGRVDGGVGLALEEHIEIKAKESET-------------------------------------------------------------------FVLKGEPINRERFEIAAAKMAEYCGRGAEIEVVSDYDAHVGLGSGTQISLAVGRAFSELYG------LNLTTRQIAEIMGRGG-------TSGIGVAVFDHGGLVV------------GHSTKEKKSFLPSSASRAKPAPMIARLDFPDWNVVLAIPDLKGFFGEREVNLFQKSCPVPLEDVREI---CHLILMKMLPAVVE-----------------------------ADLDEFGKA-------LKRIQELGFKKAEVEQYGELIKGCFD--LADCIGMSSTG--PTVYAITDSNAGGIRSLRDYFAEKGYRTIVTKARNRGVEIE......... 312
9 -20.500[EH] COG1685 Archaeal shikimate kinase  ali follow..  13  1MRGSGRASSAITIV-------AFATGKGAAIGIELWTEARVRVTGDGEVRGKIV------------------------VKGEEFKDYRLVNSVISVLREVTGEPFG----------------------------------VRFEIHSDIPVGKGLKSSSAAANSLTKALVEALR------LNIDDLSIVKLGVEAAKRAGVTTGAFDDACASYFGGLCITDNYEM----------------------------EILVKREINPETVVLLIPRETVLTESL--------------KGVDFSKISPFIGEALRLAIS--------------------------------GEWKKALVINGLLYSTF----------GYDLAPMREALKLGAF--VGLCGKG--PAFFAIADEPEEIIEAWSS............................... 264
10 -19.800[E] KOG1537 Homoserine kinase  ali follow..  10  1.MQKFQIKVPASSANIG------PGFDVLGMSLEEYMTLDVEVSTESG-------------------PCVLTYEGDGKEHVSLDVQKNMITQTSLYVLRCNNISTFP-------------------------------YATKIHVINPIPLGRGMGSSGSAAIAGVMLANEIAK------LGLSKLQMMDYVLMIE-------RHPDNVMASMMGGFGSFLRELSEEEKNAFSPSADDLLKNEALTLPPKSLGTFARLPWASELKAIVVIPEFHLATSKA-----------------------------------------------RSVLPTSYGRTDVVYNLQRLALLTTALGQTPINPHLVYEVMKDKVHQPYRASLIPGLQNIPGLCGICLSGAG--PTVLALATGNFDEIHAMLSIFEKHGVRYLVLSPAFDGATVKY........ 337
11 -19.600[E] COG0083 Homoserine kinase  ali follow..  11  2...SVVVYAPASIGNVS------VGFDVLGAAVSPIDGTLLGD---------------RVKVEAGAEAFTLKTAGRFVDKLPANPQENIVYDCWQVFARELEKKSVV------------------------------LKPLTMTLEKNMPIGSGLGSSACSIVAALDALNQFHA------SPLDETELLALMGEMEGKISGSIHYD-NVAPCYLGGVQ---------------------------LMLEELGIISQSVPSFDDWYWVMAYPGIKVSTAEARAILPAQYRRQDIVAHG------RYLAGFIHACHT-----------------------------QQPELAAKMIKD------VIAEPYREKL--PGFAKARNYAASA-GALATGISGSG--PTLFSVC-KEQAVAERVARWLEQNEGFVHICRLDKQGSKVTGSE...... 317
12 -19.300[Q] COG4542 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase  ali follow..  11  42.VHSSDALCCGELLQ-DSHFL-------VTMPIALFARAHFIPIAGTR------------------------------SVTVYPSHKVKAKRLAENLVTALSATG-----------------------------------GVLLLQSELPEGKGLASSSADLVATARSIACCFR------RRVRTSLIEKLMAEIEPS-----------DGVMYPGVVAYQQRACRL---------------------------LSFLGQMPPLAIVGIDEGGTVETVDYDQRRGEISTNQRAEYQELLNRARIAIPW------------------------------------GDAATIGKIATSSALLHQER-------TPKKHLNSMLKACEAT-SALGVIVAHSGT--IGILLDRMAADFPRKLRSVLAR........................... 315
13 -14.600[I] COG3407 Mevalonate pyrophosphate decarboxylase  ali follow..  10  29.GEIHYGSGYPITGLIGDESLKIANFPSISLNTDVSEAYSAFMISKDNGNDTAVVE------------------------ENSPNITKKAMTAINVFKNLYDIKGS----------------------------------FYLRIKRKYAGAKGLGESAAVAAAASRSLVSALFEKEALKDSNFISIVARL------------ASG-SGSKSVAGPLSLWLTAP----------------------AVSHEGSFSLNLRKEIDDIFLCAVPIRDSVSTAEAHNTVIKSPFYQQWSRLQFDAVYSIISR-----------------------------------GGYSAQIIENATTNTYLMHSVLISTGKLLWNQDTLRAMGIVEDMIGRLIGFSIDTG-----VLVMADREDLIKEFKER---YNGECIDASVPNGAPDIPESAERYFAK 358
14 -12.000[I] KOG2833 Mevalonate pyrophosphate decarboxylase  ali follow..  9  6WVFMVTAQTPTNIAVIGDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMWLNG---------------------KEISLSGSRYQNCLREIRGRAGDVED------------------MEKGIKIRKKDWEKLNLHIASHNNFPTAAGLASSAAGFACLVFSLAKLMNV------DEDPSHLSAIA---------RQGSG-SACRSLFGGFVKWTMGSKEDGSDSVAVQLADEKHWDD---------------------LVIIIAVETSSTSGMRESV----ETSLLLQHRAKEVVPKRILQMEEAIKN-----------------------------RDFASFTQLTCTDSNQFHAVCLDTSPPIFNDTSHRIISLVEKWGTPQVAYTFDAGPN---AVLIARNRKVAVQLLQGLLYY.......................... 329
15 -10.900[I] COG1947 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase  ali follow..  8  2...RTQWPSPAKLNLFGYHTL-----QTLFQFLDYGDTISIELRDDGDIRLLTPVEGVE-------------------------HEDNLIVRAARLLMKTAADSG----------------------------RLPTGSGANISIDKRLPMXGGLGGGSSNAATVLVALNHLWQC------GLSMDELAEMGLTL----------GADVPVFVRGHAAFAE------------------------------GEILTPVDPPE-KWYLVAHPGVSIPTPVIFKDPELPRNTPKRSIETLLKCE----------------------------------------FSNDCEVIARKR--------------------REVDAVLSWLLEYA---PSRLTGTGA--CVFAEFDTESEARQVLEQ............................... 260
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.