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Query: [U] COG3946 Type IV secretory pathway, VirJ component, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKQFKIRSVLQSIALLVLAGTAAAEPKPEKITHGRFEQIPVLRPDGEPQRVVIWFSDAGHVDQRTRQAEILRQDGAMVALVDTTHLYKVLAADSNHCTFSVGDVENLSRYLQAYYRDKTYRLPLLVGDGDGSGLVYAVAAQATENILAGVVSDGLCPVVVPTQAVCGAGVASDQHLKPAPVAAPLLVMTVSSAHCPAQLTSGFVRKVALGREIRLAASADLLPRLRAALRVLGAQKGVSLPPPPADLDGLPVVEVPSKAQKKSDTFAIFVSGDGGWAEIDKKVAGHLADADIPVVGLDSLRYFWSERTPEGFAKDLDRIARFYAHHWKRNRLLLVGFSQGADVLPAAINKLSPNTRQIIRMTALLSLGKYAHYEFHVSNWISTDDEGIPIAPDMVKLRSTRTVCIYGVDDQETLCPSLPQQNRRVALPGTHHFNGDYETVAKTILAQMEAAPLast
1 -95.600[U] COG3946 Type IV secretory pathway, VirJ component  ali  100  1MKQFKIRSVLQSIALLVLAGTAAAEPKPEKITHGRFEQIPVLRPDGEPQRVVIWFSDAGHVDQRTRQAEILRQDGAMVALVDTTHLYKVLAADSNHCTFSVGDVENLSRYLQAYYRDKTYRLPLLVGDGDGSGLVYAVAAQATENILAGVVSDGLCPVVVPTQAVCGAGVASDQHLKPAPVAAPLLVMTVSSAHCPAQLTSGFVRKVALGREIRLAASADLLPRLRAALRVLGAQKGVSLPPPPADLDGLPVVEVPSKAQKKSDTFAIFVSGDGGWAEIDKKVAGHLADADIPVVGLDSLRYFWSERTPEGFAKDLDRIARFYAHHWKRNRLLLVGFSQGADVLPAAINKLSPNTRQIIRMTALLSLGKYAHYEFHVSNWISTDDEGIPIAPDMVKLRSTRTVCIYGVDDQETLCPSLPQQNRRVALPGTHHFNGDYETVAKTILAQMEAAP 452
2 -32.200[R] KOG1552 Predicted alpha/beta hydrolase  ali follow..  12  66...............................................................................................................................................................................................................................................EAFFTRTSRGNLITCIYVRCSKNAKYTLLFSHGNAVDLGQMSSFYLTLGSQNCNIFGYDYSGYGMSGGKPSELYADIEAAWQAMRTRFNPETIILYGQSIGTVPTVDLASRHE------VGAVILHSPLMSGLRVVFRNTKRTWFFDAFPSIDKVAKV-KAPVLVIHGTDDEIGIYERCPKTVEPFWVEGAGHND-LHPHYYERLRKFLSVE. 283
3 -29.500[R] COG3571 Predicted hydrolase of the alpha/beta-hydrolase fold  ali follow..  13  5..............................................................................................................................................................................................................................................................FLFDGPGDAPVTILLAHGAGAPMDSMTAAAMALAGVGFRVARFEFGYMAARRTADGRRKTLNPEYRAAIAELGAQGTLVIGGKSMGGRVASMVADDLHAE--GKIAGLLCLG-----------YPFHPPGKPDQLRTRHLTDL-KTPALICQGTRDEFGTRDALSDRIELLWLEDGDHDADHLKTLAEAVARWADRAP 213
4 -28.500[R] COG2945 Predicted hydrolase of the alpha/beta superfamily  ali follow..  7  7.....................................................................................................................................................................................................................................................NGPAGRLEGRYQPSKEKNAPIALILHPHPQFGGTMNNLFYMFQQRGFTTLRFNFRGIGRSQGEFDHELSDAASALDWVQALHDSKTCWVAGYSFGAWIGMQLLMRRPE-----IEGFISVAPQPN-----------------TYDFSFLAPC-PSSGLIIHGDQDKVAPPKDVQATITQKTIASNHFFTGQGEELIEECSEYLDRR. 210
5 -27.600[R] KOG4391 Predicted alpha/beta hydrolase BEM46  ali follow..  14  102..................................................................................................................................................................................................................................................................SVSWDTLSCYDLDLRIPDIAHRLEMVRIMIQKKCNVFMLSYRGYGASEGYPSQIIKDAQAALDHLSGRTDTSRIVVFGRSLGGAVGAVLTKNNPDKVSALILENTFTSILDMAGVLLPFLKWFFVVRSPWKTIDAIAEI-KQPVLFLSGLQDEMVKAAARNPQCTFVEFPSGMHMDTGGEVYWKTNLQFLEKY. 324
6 -27.100[I] KOG4667 Predicted esterase  ali follow..  16  77...................................................................................................................................................................................................................................................................ETGSTDIVVLCHGFRSNKSIMNNVAAAIQKEGISAFRFDFSGNGESEGSFYYGNDDLHSVVQYFSNK-NRVVPIILGHSKGGDVVLLYASKYHD-----VRNVINLSGRYDLK-GYRVTEKSLMDRLSTDIHEACLKIDECRVLTVHGSEDEVIPVEDAKPNHKLEIVEGNHGYTEHQSQLVSTVMEFIKT.. 303
7 -24.100[R] KOG4840 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)  ali follow..  11  30..................................................................................................................................................................................................................................................................TSNVTRSLLLFVGGLGDTVPYVQELVNPLDEIGWSIVQVQTQSSYIGWGTGSRDDEDLHKAVDYFLHDFSTRKIVLMGHSTGSQNVLYYLTQ--SILPNYLIAGIAQAPVSDREFSSDLSADDFAKTFGNLKEISGSTA-HSQLILLMSERDEESIRPTTSNSSLSGIIPGATHNPEALKWLINQLITALRSF. 313
8 -23.100[R] COG1647 Esterase/lipase  ali follow..  11  12....................................................................................................................................................................................................................................................................EKGKRAVLLLHGFTGSSADVRILGRFLQENNYTCYAPQYRGHGVSPDGPNDWWEDVLAAYDHLKSL-GYTEIAVAGLSLGGLFSLKLGFSRP------LKGIIAMSTAEMVAYKDAPMNTIAKLKDEINGVVSEIDMIYAPIMVVQGEKDDMVDVSGASTKKELHWFKESGHLDKERKDVNQAILTFLDS.. 243
9 -22.400[R] COG3150 Predicted esterase  ali follow..  9  2........................................................................................................................................................................................................................................................................STLLYLHGFNSSPRSAKLLKNWLAEHHPDVEMIIPQLPPYPSDAAEL--------LESIVLEHGGDSLGIVGSSLGGYYATWLSQCFMLP-------AVVVNPAVRPFELLQQYVLESRHIYDLKVMQIDPLEAPDLIWLLQQTGDEVLDYRQAVASCRQTVIEGGNHAFTGFEDYFNPIVDFLGL.. 190
10 -21.700[R] KOG1454 Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily)  ali follow..  12  76...................................................................................................................................................................................................................................................................QLHDKSPVVLLHCFDSSCLEWRRTYPLLEQACLETWAIDVLGWGFSDLEKLPPCDSKRHHLFELWKTYIKRPMILVGPSLGATVAVDFTATYP----EAVDKLVLINANAYSEGTGRLKELPFMISGGYNVASHIKHI-DHKTLVVCSENDQIVSNQLSVANAVLREVPDSGHL-ENPKHIVKLISDFASG.. 326
11 -21.700[R] COG4757 Predicted alpha/beta hydrolase  ali follow..  12  4.............................................................................................................................................................................................................................................DAFPVSLAAADGYVLGGCRYPADTALKGRLVVAGATAVPQGFYRRFAQFAGTRGFETLTFDYRGIGQSRPPSDWARLDLAAAVDTMAD--GAVPLYVVGHSYGGHAFGLLPNHRKVAGFCVFGTWNAVLPVLTWWKGYCPWKMLGLGEDAMRGIEQAYADVRTPIVAVNALDDLWAPPASRDAFMQGYRNAPGHMFRQAGEPLWERMLGWFSS.. 282
12 -21.600[I] COG2267 Lysophospholipase  ali follow..  13  27.................................................................................................................................................................................................................................................................ALQPGAKKVIVLFHRGHEHSGRLQHLVDELAMPDTAFYAWDARGHGKSSGP-ARSVRDVDEFVRFAASDVGLEEVVVIAQSVGAVLVATWIHDYAPAIRGLVLASPAFKVKLYVPLARPALALWHRLRGLFFINSYVAAAITLPTQLLISGDDYVVHRQPQIPLKELHLLPGFYHGEENRALAFEK......... 274
13 -21.000[R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)  ali follow..  16  23......................................................................................................................................................................................................................................................................AGQPIVLIHGFPLNGDSWEKQVLVLLNAGYRVITYDRRGFGASSQPSDTFAADLHTLMTKL----DLQNTVLVGFSMGTGEVTRYLGKYGSE---RVQKAVLMAPVPPFLLKTNKGTLDCVPSWLTDFRDDLPRI-DVPTLIIHGDADRILPLESTAANSQLEIIPGGPHA-THADQVNPLLLNFLQ... 276
14 -20.500[I] KOG1455 Lysophospholipase  ali follow..  14  74........................................................................................................................................................................................................................................................TLFTQSWTPVDSAKNRGLVVLLHGLNEHR--YSDFAKQLNVNGFKVYGIDWIGHGGSDGLHAYVPSLDYAVADLVIAENPGLPCFCIGHSTGGAIILKAM--LDAKIEARVSGIVLTSPAVGVQPTYPIFGVIAPFLSFLIPRYQLSAAKKVPFLVMHGTADTQKLYNEASSSDKSIKLDGLLHFEPERETIAGVILDWLNR.. 331
15 -20.500[I] KOG4178 Soluble epoxide hydrolase  ali follow..  8  60.............................KVNGINMHVAEKPGSGSGEDPIILFLH--GFPETWRHQMVALSSLGYRTIAPDLRGYGDTEAPEKVEDYTLLKRGRSVVALIVAVTG--GDKAVSVVGHDWGAMIAWQLCQYRP-EKVKALVNMSFQKAGEIETEFKKLGTENVLKEFLTYKTPGPLNLPKDKYFKRSENAASALPLWLTQEDLDYYVTKYENKGFTGPINYYRNIDRNWELTAPWTGAKIRVPVKFIGNGAIRPPVILFLHGFPELWYTWRHQMVALSSLGYRTIAPDLRGYGDTDAPESHVVGDLIGLIDAVVG--DREKVFVVGHDWGAIIAWHLCLFRP----DRVKALVNMS...................................................................................... 502
16 -20.000[R] COG1073 Hydrolases of the alpha/beta superfamily  ali follow..  12  87..............................................................................................................................................................................................................................................................LPKNRGGDRLPAIVIGGPFGAVKEQSSGYAQTMAERGFVTLAFDPSYTGESGGQPRNVTEDFSAAVDFISLL-NRERIGVIGICGWGGMALNAVAV------KRVKAVVTSTMYRAVNSGNAWTMTTPLSFMNMPILTYIKEISPRPILLIHGERASETAYAAAAEPKELLIVPGASHVDRLDRIPFDRIAGFFDE.. 365
17 -19.000[R] COG0400 Predicted esterase  ali follow..  13  1...........................................................................................................................................................................................................................................................MKHIFRKGADPNAPTLLLLHGTGGNEHDLVPLAEMISP-GSSILGVRFRRIAEGVFDEEDLVIRTKELHEFLDDA-NRNRLVAIGYSNGANIAASLLYHYE----QPLMGAILFKAMVPLR------------------NRTVPDLQQMPIFIGAGKYDPLIPQTETKELINTLTNAGGHQLTEEVERAKEWFNEQFLEA. 204
18 -19.000[E] KOG4627 Kynurenine formamidase  ali follow..  17  63.......................................................................................................................................................................................................................................................GRQLVDVFYSEKTTNQAPLFVFVHG-GYWQEMDMSIVGPLVRRGYRVAVMDYN----PQVTLEQLMTQFTHFLNWITEMTKVSSLTFAGHSAGAHLLAQILMRITAQRSKMVWALIFLCGVYDLR-SVNPKNILGLNERNIESVSPMLWEYSTKIYVVAAEHDSTTVLRKKGYKASFTLFKGYDHFDIDDSDVSRFLRNIEIE.. 300
19 -18.200[R] KOG4409 Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily)  ali follow..  13  144.......................................................................................................................................................................................................................................................STITVNCESEQPIVKAKYPIVLIHGFGAGVALWGSAIKRLAQF-QTVHAFDLPGFGRSSRDPETAETEMIDSIEQWRDKMNLEKMNLVGHSFGGYLATSYALKYP----KRVENLILADPWGFNEMDPEFAQKLTSGWAKQPMSKRFHELDTVPVTFIHGERSTRRLFGELEHVESHIMDSAGHHVYADDDKFVQLVIGSLKDG. 424
20 -18.100[R] KOG2564 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold  ali follow..  13  52...........................................................................................................................................................................................................................................................FRIYRTKQPEKPGPVLLLLHGGGYSALTWAHFCSEVTSMHCQCLCIDMRGHGDSKVDDEDLAKDIGDLILKLYPE-EVPQLFVVGHSMGGAIAVHFAHMALVPNLIGIT-VIDVVEGTAMEALASMQSFLRSRPKYFQSIPNAIESEKYWVGWFSGLSDRTLTVGQMQGRFQMQVLARGHAVHEDRHEVAEVISGYLIR.. 385
21 -17.600[R] KOG2382 Predicted alpha/beta hydrolase  ali follow..  11  17.....................................................................................................................................................................................................................................................STSSMMLANLTFGNMRSKGTPLILVPGLFGTKENWIQVGKDLSQRGCMVFAVENRNHGSFSKAASEMADDLVGFIDWVRKITGEDKVNLHGHSMGGKAVTQLA--TTPEYSSRIKSLIVEDMSDMNKSRSEVMAELGEKVSKVLLYQFVRG--DGPTLFQRAPGAHKNRVEKMFPMVQFAETAWSNHWADDPKFFVDSICEFLEEP. 288
22 -17.200[R] COG4188 Predicted dienelactone hydrolase  ali follow..  11  58..............................................................................................................................................................................................................................................................RPQRWKEGKTPVLVFSHGLASRPEDFDNAAEKMASYGFVVALPQHPGSDILQAQA-DRPKDISYVIDELERRLNLTQVGVGGHSFGGYGALAVAGATIDWDFPRVVAVLAANPVNSAIF----------------GVSGLHKV-TVPVLLLGGSYDPATPFVLASRDKYLTLMEGQAHVD.................. 286
23 -16.500[Q] COG3458 Acetyl esterase (deacetylase)  ali follow..  9  73.............................................................................................................................................................................................................................................................LLVPKLEEEKLPCVVQYIGYNGGRGFPHDWL-FWPSMGYICFVMDTRGQGSGWLKGDRVFTDAVRAVEAAASF-DQERIVIAGGSQGGGIALAVSA-----LSKKAKALLCDVPFLCLKTHRDKEEIVFRTLSYFDGVNFAARA-KIPALFSVGLMDNIAAYNYYAGPKEIRIYPYNNH-SFQAVEQVKFLKKLFEKG. 325
24 -15.700[R] COG4814 Uncharacterized protein with an alpha/beta hydrolase fold  ali follow..  13  31.................................................................................................................................................................................................................................................................PKAANDAIPTIFIHGYRGTDRSLHGMIRRFDQKY-PLINIV---FEDNRATLPQQSMWTKKIMSYLQKNYDIKKFNAIGHSMGGGAWVSYLASYEKNKSPQVNKIVFLAVPFYPEEYVNGDQQVDIKNANNVHAKFAQKMDNTEIMIIGGNSDGEVKLNSVLYGQKLFAHQKTHSSMHESTVVDKYVGQFL.... 269
25 -15.500[R] COG0429 Predicted hydrolase of the alpha/beta-hydrolase fold  ali follow..  13  53....................................................................................................................................................................................................................................................PDGDFVDLAWSEAPAQAQHKPRLVVFHGLEGSLNSPHGLVEAAQKRGWLGVVMHFRGCSGEPNRMHRITEDASWFLRWLQREFGHAPTAAVGYSLGGNMLACLLAKEGNDLPVDAAVIVLKSVRRIREFDDLITARIHGYADAIDYYRQCSAMPAKPTLIIHAKDDPFMDHQVIPKPESQLTEHGGHTLLHPQMWLESRIPDWLTTY. 334
26 -15.300[R] KOG3043 Predicted hydrolase related to dienelactone hydrolase  ali follow..  10  30...........................................................................................................................................................................................................................................................LDTYAAGSTSPKEKVIVILTDVYGNKFNNLLTADKFASAGYMVFVPDI-----QRHSPEVTKKIVDGFMKLLKLEYDPKFIGVVGYCFGAKFAVQHISGDGGLANAAAIA-----------------------PSFVSIEEIEAIDSKKPILISAAEEDHIFPANLRHLTEEKLKDNHAHGFAARGDISIPAVKYAKEKV. 232
27 -14.700[I] KOG2112 Lysophospholipase  ali follow..  12  1...................................................................................................................................................................................................................................................MAAASGSVLQRCIVSPAGRHSASLIFLHGSGDSGQGLRMWIKQVLNQDLTF--FDRFKITNDCPEHLESIDVMCQVLTDLIDE-KKNRILIGGFSMGGCMAMHLAYRNHQDVAGVFALSSFLNKASAVYQALQ------------------SNGVLPELFQCHGTADELVLHSWAEETNSMLKSLGYHELSTELDILKLWILTKL.... 229
28 -14.700[R] KOG1838 Alpha/beta hydrolase  ali follow..  18  143..................................................................................................................................................................................................................................................................PGTDRTPIAIIVPGLTSDSSAAKHIAFRLAKEGWNVVVQNHRGLGGISLTSDCVTEDLRKVIAHIHSQFPEAPLFAVGTSIGANVLVKYLGEDGPNT-PLIGATAVCSPWDLLICDRFINRKLVQKVYDRMLTIGLQGYVAVPLLCISALDDPVCTREAIPWDE-ATTTHGGHGLTASSMWWTRVVHEYFEVL. 409
29 -14.600[Q] COG0412 Dienelactone hydrolase and related enzymes  ali follow..  13  39................................................................................................................................................................................................................................ASTIVQTPDDAIVAGFTSIPSQGDNMPAYHARPKQSDGPLPVVIVVQEIFGVHEHIRDICRRLALEGYLAIAPELYF---AKVPDSQVLADLDHVASWASRN-DVHRLMITGFCWGGRITWLYAAHNPQ------AAVAWYGKLTGDK----------SLNSPKQPVDIATDL-NAPVLGLYGGLDNSIPQESVETMRQALRAANGHAFNADYRP--QRMLEWFKQ.. 286
30 -14.400[O] KOG2100 Dipeptidyl aminopeptidase  ali follow..  9  297.......TYTLSIWNKKTEQSRQLDVQLKDSLSYHYLLAVKWLEINGTEQLVSVWTNRYQNEVALTICDWDTAICRLEFEYDTLFFLLPHDKRDNAFQQVASRLSHGQLRTPKFLNLGEYDVTSINGINKETRTIFFHAAA-PKPSHRSLFSYSLADE-SRNSAYCISCSIKNCTWAQAQMDDQMKTAIVSCKGPAAPHTAIVNLTRMDSDKKTEHANLLYDKTYQNRVEEAGLPVIIKETIKISDDFDALIKLSIPKDIYNRDPLIVHVYGGPNDQNTKEATQVVASASQAAILRIDGRGSGGRGWKYRSAVEDQIKAIKVVLRLYDARRVAVFGWSYGGFMTLSMVNEAPEQF---FKCAVSVAPVTNFAYYDATYTERYMGDAPLEVTKKLDNFKSTRLLLMHGLLDDNVHFQNSAILIDELQNRGAHSLSSRTSHVVGKMTHFLRQ.. 793
31 -14.100[E] KOG2551 Phospholipase/carboxyhydrolase  ali follow..  13  1.............................................................................................................................................................................................................................................................MAPEIHLKPKNPRILCLHGFRTSGRILQAGIGKWPDTDLDLDFLDAP-EWYQANKGFKEYRNFEECLAYIEDYMIKN---LLGFSQGAFLTAAIPGMQEQGSAPKVKFLVIISGAKIPGLMFG---------EPKAAVNAFSSPVRCPSLHFIGERDEGEVLVESFVEPVVIHHSGGHIIDTKAEETMLSFFQSIRQM. 222
32 -14.000[R] COG1075 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold  ali follow..  14  62.................................................................................................................................................................................................................................................................DSYAATKYPIIFEPGFGGVIDYFYRIPEDLRAHGANVYLSTSSAFQ-RPDGPNGRGEQLLAYVKAVLAITGAEKVNLIGYSQGGLTVRYVAAVAPS----LVASVTTMGT..................................................................................... 172
33 -13.900[Q] COG3208 Predicted thioesterase involved in non-ribosomal peptide biosynthesis  ali follow..  10  5..................................................................................................................................................................................................................................................................APMTLRPRLICLPPAGAGPSLFRSWVQNSES-IFDVVPVALPG--REAHFTKPLPRDIQSLADHVTNEIIQAPYALFGYSMGAVVAYELLRHLSLRRLPLPDAFYILGPDEILRDREAMALFEPVLRNDFRICETYEFTPTFPVHVFVADADHLVSWKAAGADITMHGIEGSHMLPQAFAHFIGKLGQLWQTD. 242
34 -13.700[I] KOG3847 Phospholipase A2 (platelet-activating factor acetylhydrolase in humans)  ali follow..  12  98...............................................................................................................................................................................................................................................................QLSTKSDKWPVLVFSHGLGGSRTFYSTYCTSLASHGYVVAAVEHRQFKIRNEQVGKRAEECAKAVKILEQKLLTTTASIIGHSFGGATSIASSSS-------------------------DFQKAIVLDGWMYPLDQNQQEQAKQPIMFLNVGDEVMRKILPNNEGNILLTLSGAVHQSTDFPFVFPNWLAKQFGV. 332
35 -13.300[S] COG2830 Uncharacterized protein conserved in bacteria  ali follow..  7  7...................................................................................................................................................................................................................................................................DYQGEHLILYFAGWGTPPDAVNHLILPENHD---LICYDYQD------------------LNLDFDLSAYRHIRLVAWSMGVWVAERVLQGIRLKSATAVNGTGIFKGTLENLTENTRLKFERRICGDKASFERYQLFPAHWANAWVSSRDKIFTPANQALRCAVQEIEGEHYVFSRFTHWSALW........ 213
36 -13.200[I] COG0657 Esterase/lipase  ali follow..  15  63................................................................................................................................................................................................................................................................SPRFLMVGHAVLYAHGGFGSPMASRALCASLADEGAKFYIPAYQ---APEHPFPAALENMYDAYVALIDQKKPEDIIFSGDGAGAGLMLALTHYLKQKGLVCPRALALISPWVDLTFRYCALQYTYADNFRNSLVSPLGNFGDFPPVFVQGETDACALAQILEGAGVQVTLPGMWHLFQSMESVSPCAHIAVARM. 291
37 -13.000[Q] COG3319 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases  ali follow..  16  2...................................................................................................................................................................................................................................................................AGGSRPPLFLVHPLGGHVLCYLPLVRAL-PPDQPVYALQAAGTGQGSTPLAVLEDIAASYLAAIRRVQPEGPYYLGGWSFGGFVAYEMARQLRALDPQAVAQLIVLSLEQKLDHIVERAIEAGVLPAGTPLIGYRPEVSDQDMTLLRADGPLPLALKPTSGRLDVIDVPGDHL-EPYVETVAAEIAALLEPSP 282
38 -12.900[R] COG4099 Predicted peptidase  ali follow..  10  1MLTRRKFLMMSAGAGLLLSVPMLARTGVQPAQ--AATAITQVFGDGIRLTAVAVEYPTE--------AEGLNPADFHVEGRTVTGVWTSTSTNPADIA------------------------------PSGRYMIIALSPDDKNATLAEQVQPNSKNNSNKSANGRGGPGNAGDIPAYDTVYRTAQATVLRLPSVHTASGDTLPASEKALTTQYVENLIVDDFQQLEFYDEKTGKKLKYNLFIPKDYSPDKDYSPDKNYSPDKAPLVLFMHDAGGLGAIAWASPEDQAQRPCFVLAPQYEIIADDDSKTSDMLDTTIDLINVLSEQYDKSRIYATGQSGGCMMTIAMNIKYP----DFFAASFLVAGQWDP--------------------ALVKPLAQQKLWILVSQDDN-KAWPGQNAIIDVLEKEGVQISRAIWDGTWN.......... 395
39 -12.700[R] COG3545 Predicted esterase of the alpha/beta hydrolase fold  ali follow..  12  2....................................................................................................................................................................................................................................................................KVSETHILIVPGYTN--SGPNHWQTRWERKLSTARRVEQAE--WSKPVREDWVARMIEEVNAA-----EKPVVIVAHSLGVATAIHALPHCT----RQIAGAFLVAPPDVANPKIR-------PKHLMTFGPYPRDPLPFPSVMVASRNDSFGSYEHAGDGSLLVDAGDAGHINGPWPEGSMVFAQFLSRL. 182
40 -12.500[S] COG4782 Uncharacterized protein conserved in bacteria  ali follow..  12  182..................................................................................................................................................................................................................................................................SKSPDRSVLVFVHGNNRFEDSVYRFAQIVHDSGIKSAPVSLLAYGYDRESTNYTRNALESLFQYLAEDGEVKEVSILAHSMGNWLTLEALRQMNDGLPAKFKNVMLAAPDVDVDV---------------SQIEDMGSQHP-RFTLFVSRDDRALAFSRAENEITVIDLTKHHGKFAESPEVVRLIGARISE.. 401
41 -12.200[Q] COG3509 Poly(3-hydroxybutyrate) depolymerase  ali follow..  11  48.............................................................................................................................................................................................................................................................LYKPVGLPSSAPLVVMLHGGFGSAKQAERSYELADSEKFLVAYPDGYHRAWNANPAREGVDDVRAVVADIANNVDPARVYVTGMSNGAIMSYTLACNT-----SIFAAIGVVS----------------------TQLDPCQSPRPVSVIHIHGTADPLVRYHADNRRVVLLTVDDAGH-----SFATQTLWRFFAAHF 279
42 -11.600[IO] KOG2541 Palmitoyl protein thioesterase  ali follow..  14  13...........................................................................................................................................................................................................................................................VVAFLAKVDISVSVPFIMLHGIASQCSDDTNANFTQLLTNLSGSPGFCLEIGNGVINSLPLTQQAEIACENVKEMKESQGYNIVGRSQGNLVARGLIEFCDGG--PPVFNYISLAGPHAGISSLPRSKYLPKLNNEIPNQRNQTYKDRFNLVLVKFQDDEVITLKTLDDAGKVKSVPGGH-VRMAEEDVVKYVVPYLQNQP 293
43 -11.300[E] COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases  ali follow..  8  174......................YPGGEVLLEKGGVNYNIVDFDFAPDDNTIVYAVSTDMKKPFIHKLVLWDLASGREKTLIEGLTIAAVAFDPRGRYIAVKAN--------DRKRGLFSHYKIFVYDLNSEEFVCLTCDLDLNTLNTGHLYYGVHNAGRMVVMKSRPLGEAEAVLDPSSATVDDFSISRGGDTIAYVKMGPTSPPDIYIYRDDNEYRLTDHNAWFAESRSLAEPVRLQVQSPLGGSIDAWILLPPDAGECSGCLPWILYIHGGTSYGYAFIHEFQMLASQGFAVIYSNPRGYSEEFADLRG-YSELMKVVDEALSDFPPQRGGVTGGSYGGYMTNVIVTK-TRRFKAAVTQRSCISFYGESDIGWYFAPELISAQEPWRDLEKYVDFSPTPLLIIHSTEDFRCPLSGAIQETRLLVFPGENH--KRRVARLRAIASWFKE.. 651
44 -11.000[R] KOG4372 Predicted alpha/beta hydrolase  ali follow..  10  2...........................................EAGRSADEVLY-----------------HNQSSVKLG-ELERYVITYELYQGDSIPADITLDSLWVKIKNTTKL-SYKPAYLLG--------FILYCDVRAKDYESSYKIICSADKPVFQSNLQAQQKFIAELSLHHIKPRYVIVDIVSQILFNKETKVTFEIVVGNSKASLKRKIRCNDSLPDKACNILHTGLSVHRLTTADIWKVP----RPIDMSQKSHLVILTHGFQSNVSADMEYLMEEIYK---VIKGYMKNACETEKGIKFLGVGLANYIIDELYDDSVGKISFIGHSLGGLTQTFAICYIKTKYPEPINFISLASP..................................................................................... 309
45 -10.800[I] COG3243 Poly(3-hydroxyalkanoate) synthetase  ali follow..  10  276.....................................................................................................................................................................................................................................................KSPLCEIIHYAPTTEKVFKPPLLIVPP----LNPQKSFVGWCLEQGHSVFMVSWINPDAGLANDDYINEGIDFALDTIEERTGEKQINAIGYCVGGTLLSSALALHAQQGNERIRSATLLA--AQTDFIHAGDLKVFIDEGQLAALDKHMGDITIPVYDLATRDDHIAPAKSFGGTVEFVLGASGH..................... 559
46 -10.700[I] KOG2369 Lecithin:cholesterol acyltransferase (LCAT)/Acyl-ceramide synthase  ali follow..  14  16................................................................................................................................................................................................................................................................NAGEVADRDPVLLVSGIGGSIYHFHDMIEMLVGCGYKGYGYDFR----QSNRIDLLILGLKKKLETAYKRSGGRKVTIISHSMGGLMVSCFMYLHPELVECP-EMMANPDFKWKKQPEIRVFAILDWAAKTREILNKAQLPDGVSFYNIYGVSDGTVPAESAAKAVASVGVSGSHRGLLRDERVFELIQQWLGVEP 376
47 -10.600[I] COG3675 Predicted lipase  ali follow..  9  18.....................................ELEFRSENDEPDGLLVTITNQSAPSNTYTQTT---SSGKWRASVSQASLLTEVEKYASRKEGQESPVKKRAAAELDAADKDTKQ--TTIG--AGFRLSHNVIIDTDEFNLVNSYTFALLSKLAYFNRDDGKTIDNQGAISTVISQLKRKERPTYSGDLQAKWLLEEIPYSKALSAQYYAEDDVGSEGYIIFNDELAIIGVRGTEPYFQSKKPPVDNTKFKIIKAASGMAAVIADKIESATDSPGMKDLIITDLDAAQIAPEEFGGTYVHRGFYQYTMALLSLMEKDLGLHKIKKFYCCGHSLGGAGALLISALIKDSYHPPVLRL-----------------------------------------YTYGMP-------------------GTRSFVERYQNILHRHVDLVPQIP 431
48 -10.300[S] COG4947 Uncharacterized protein conserved in bacteria  ali follow..  11  33....................................................................................................................................................................................................................................................................HAGRPVVVFPTSQGRFYQGVGALAEFIDTGRIQLFTVDGIDSESHEAYFRYVREEALPEILSAANGGRKLKPLFSGCSMGGYHSSNFVFRFPELASGVISLSGVYSARDFFGKVLDGDIFYNSPLDYLPGIVDLARLKALRLIFCCGQGAWEERMKSIPAWVDYWGGDVSHDWPWWHKQLVYFFGRWLDD.. 260
49 -10.200[I] KOG2624 Triglyceride lipase-cholesterol esterase  ali follow..  12  134...............................................................................................................................................................................................................................................EAIRVITSDGYVLVLERIP-RRDARKAVFLQHGSMGWVGVVGSPAFAAYDQGSSLKFWRYSINEHGTEDIPAMIEKIQPNIDEEINQEEPYKLCAICHSLGGAALMYVITRKIKEKPHRLSRLILLSPAGFHEDTRFFRMLLNKLARDFHNYPALGGLVQTLMSYVVGGDSSNWV-VSFRVAQHLAQIKHTGKFRMDYGSRSANMEVYGSPEP 407
50 -10.000[P] COG2382 Enterochelin esterase and related enzymes  ali follow..  10  159..............................................................................................................................................................................................................................................................TTGDATAEERPLAVLLDGEF------WPVLTSLTHRQAVYVLIDAHELPCNADFWLAVQQELLPLVKIAPFSDRADRTVVAGQSFGGLSALYAGLHWPERFGCVLS--------QSGSYWWPHRGGQQEGVLLEKLKAGEVSAEGLRIVLEAGIREPMAQLHPIKESIFWRQVDGGHDALCWRGGLMQGLIDLWQPLF 370
51 -9.780[R] COG2936 Predicted acyl esterases  ali follow..  14  19.................................................................................................................................................................................................................................................IVMPDGCRLSARVWMPEDAGNDPVPVILYRKRDGTIFRDQLTHPYFAGHGYASIRVDMRGNGDSEGLSEQELQDACDVIAWAVAQWCNGNVGMMGISWGGFNCLQVAAKQPPALKAVISLCSTVDRYADDIHYKGGCLLIENFGKRGSICEDFSAV-KAAVLSIGGWHDISNLVSNIEAPVKGIVGPWIHKYPHYWDRWLKGTETGVEDDP 310
52 -9.780[I] KOG4569 Predicted lipase  ali follow..  14  85...................................................................................................................................................................................................................................................................AKDLNAIIIAFRGTQE-----HSIQNWVSDLFWKQLDLNHHGFYSAYHNTTLRPAVLDAITRVKKVYGANINIIVTGHSMGGAMASFCGLDLVVNEGEENVQVMTFGQPRVGNAAF---------------ASYYSLLVPNTFRITHDRD----MVPHLPPYYYHFPQKTYHHFPTEV............... 247
53 -9.720[OR] KOG2183 Prolylcarboxypeptidase (angiotensinase C)  ali follow..  7  1MASHFCLLLIFTFFTLVFPSNGSSFADLPKFSQRYLINSDHWLGASALGPIFLYCGNEGDIETNSGFIWDIAPKGALLVFPEHRYYGESMPYGS-TTEQALADFAVFVTDLKRNLSAEA-CPVVLFGGSYGGSNNCVFVFVVIDATVLAAWMRLKYPHI-------ASSAPILQFEDVVPPETFYDIASNDFKRESSSCFNTIKDSWDAIIAEGQKENGLLQLTKTFHFCRVLNSTDDLSDWLDSAYSYLAMVDYPYPADFMMPLPGHPIREVCRKIDGAGSNASILDRIYAGISVYYNYTGNVDCFKLDDDPHG--------LDGWNWQACTEMVMPMSS-------NQENSMFPGYGFNYSSYKEECWNTFRVNPRPKWVTTEFGGHDIATTLKSFGSNIIFSNGLLDGGSVLKNLSDTIVALVTKEGHHLDKWLVDQREAEIRLIQG.. 509
54 -9.580[IOT] KOG2088 Predicted lipase/calmodulin-binding heat-shock protein  ali follow..  14  102...................................................................................................................................................................................................................................................................DHENGDVVLAIRGLNLAKECDYAVLGGYVHNGL--------------KAAMWVFEEEHVVLRELLEANPSYSLTFVGHSLGAGVVSLLVLFVIQNRVRRIRCFAIAPPR-SLHLAVTYADVINSVVLQDDFLPRTT......................................................... 243
55 -9.500[R] COG4287 PhoPQ-activated pathogenicity-related protein  ali follow..  10  116.............................................................................................................................................................................................................................................................DIYIPETAKEHHALVVVNNGINYDFPQETLASISRDTNTIVISVSWALFMEAPEQRKLMVTAISQAMRLAKKQWNINSFIITGISKRGWTTWLSAI-----ADPDVEAIVPFAID-GGNWPITFYPYYQQGIDEKIKSPAFTQLRAIPKYIINASGDDRFYYSKLPGVKSLRIVPNMNH-QFAEGSLVPFINRFQSKKT 395
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;