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Query: [M] COG3967 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein), from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAEAKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELFVDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALHSFSLTLRHHVRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLKEGKQEITNERVEGLRDATRADYDRLFEQMNTQENLast
1 -86.300[M] COG3967 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)  ali  100  1MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAEAKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELFVDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALHSFSLTLRHHVRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLKEGKQEITNERVEGLRDATRADYDRLFEQMNTQEN 252
2 -69.100[R] COG0300 Short-chain dehydrogenases of various substrate specificities  ali follow..  21  1..MRKKTIFITGASSGLGRQLAIDFSWEETVLCLFARSQERLENVQRIVVEAHIYPVDLADPQSIDRSFAEAISAVGVVDVLINNAGYGVFEPFCDSQMD--ENERMFRVNVFGLMRATAAVLPTMREQGSGHIINIASQAGKIATAKSAIYSATKHAVLGFTNSLRMELKGTGIHVSAVNPGPIQTPFFDQADKEGAYTSKMLDPEDVSEKIVQLTKKPKRELNLPWWMNIGATAYQVAPRLLELLAGKQ. 255
3 -59.500[Q] KOG1205 Predicted dehydrogenase  ali follow..  24  43EKVNGKVVIITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVVADRCPDVAVVRGDVSVIKDCKRFVQETISRFGRLDHLVNNAGIAEAKFFEDYS-EISDVLPIVNTNFWGPVYATHFAIPHL-KKTKGKIIAVASPAGWSGVPRMSIYAASKAAMINFYETLRIELHP-EVGVTIVFPGLIENGNTNPDLLAESLLQKIESAAECAKAVVNGICRGKTFVAEPSWVRVLFWLSAICPELLISKPKRN. 303
4 -59.000[Q] KOG1210 Predicted 3-ketosphinganine reductase  ali follow..  20  28LALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMVLCISVDVSDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVS--TFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFAEENRTKPLETRLCKPEQVAKQIVKDAIQGNFNSSLGSDGYMLSALTCGMAPVTSITEGLQQ 293
5 -58.700[R] COG4221 Short-chain alcohol dehydrogenase of unknown specificity  ali follow..  21  4.SLQGKIAVITGAASGIGLATTEALLEQGATVVMVDWNEKALNDLAAKLERAIPQVTNLLDADSCNAMIPEILGKVDHIDILYCNAGTYIGGDLTETTPE--AIDKMLNLNVNAVMKNVQAVVPHMSERKTGDIIVTCSIAGHFPTYWEPVYSGSKWAITSFVQGMRRQMIPHGVRVAQVSPGPVVSALLADWPEENLRKAKESDASEVADAVVYMLTRKRTVTI........................... 230
6 -58.300[I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3  ali follow..  19  44LRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIESVKIIQADFTKDDIYEHIKEKLAG---EIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLNTN----VITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRL 294
7 -56.400[Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11  ali follow..  18  49.SIAGEVAVVTGAGHGLGRAISLELAKKGCHIAVVDINVSGAEDTVKQIQDAKAYKANVTNYDDLVELNSKVVEEMGPVTVLVNNAGVMMHRNMFNPDPA--DVQLMINVNLTSHFWTKLVFLPKMKELRKGFIVTISSLAGVFPLPYSATYTTTKSGALAHMRTLRMELDQKDIHVTTVLPSFLRTNSDVTQLTHTIGVYPLFTGEEVAQRIVAGMVRGEAEITVPGMACLLYRVILILPADWQDRIIL.. 306
8 -52.900[Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related dehydrogenases  ali follow..  22  6...ESPVVLITGCSQGIGHALAREFTEKGCRVVATSRSRSTMTDLEQD-SRLFVKELDVQSDQNVSKVLSEVIDKFGKIDVLVNNAGVQCVGPLAETPIS--AMENTFNTNVFGSMRMTQAVVPHMVSKKKGKIVNVGSITVMAPGPWAGVYTATKAAIHALTDTLRLELRPFGIDVINVVPGGIRTNIANSAVAFISQRMNPTPAETFARDTVAAVLKKNPWFSSGRYSTLMAVMYHMPLWLKDFFQKQV. 295
9 -52.400[Q] KOG1204 Predicted dehydrogenase  ali follow..  27  2....GKVILITGASRGIGLQLVKTVIEEDDECIVVARTEAGLQSLQREYGKFVYRVLDITDRSRMEALVEEIRQKHGKLDGIVANAGMLEPVKSISSEHDIKQWERLFDVNFFSIVSLVALCLPLLKSSPVGNIVFVSSGASVKPYNGWSAYGCSKAALNHFAMDIASEEPSDKVRAVCIAPGVVDTQMQKDIRETLGPQGSLLDPKVPAAVLAQLVLKGIPDSLNG......................... 248
10 -48.700[R] KOG0725 Reductases with broad range of substrate specificities  ali follow..  15  2.....SCALVIGATSTLGKAVVRRLAFTGYKVAAAADCPNSVGKVAEDNIDVTAFSLDVANAEHRKELITKVAEKLGGLDTLIIVPPQNEVLG---IETSGEDFDKLFANNLTTPFRLSQAAMSTLAKSQNGSIIYLTSCFGFTPSIDMGLYSVASSSVLSLTKSVAQSAAKQGVRVNSVVSGMIEGDGTGAVWDHASGEEAR-RPSDVASYVE--LASTKARYITG......................... 240
11 -48.300[IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)  ali follow..  21  3.KLTGKTALITGASQGIGEGIARVFARHGANLILLDISDEIADELGGRGHRCTAVKADVRDFASVQAAVARAKETEGRIDILVNNAGVCRLGNFLDMSEE--DRDFHIDINIKGVWNVTKAVLPEMIKRKDGRIVMMSSVTGMVADPGETAYALSKAAIVGLTKSLAVEYAQSGIRVNAICPGYVRTPMAESIARQSNPDDRLADPLEVGELAA--LASDESSYLTG......................... 244
12 -45.300[I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase  ali follow..  20  72QKVESPVVVITGASRGIGKAIALALGKAGCKVLVNARSAKEAEEVAKQIEQAITFGGDVSKATDVDAMMKTALDKWGTIDVVVNNAGITRDTLLIRMKQS--QWDEVIALNLTGVFLCTQ-----------GRIINISSVVGLIGNIGQANYAAAKGGVISFSKTAAREGASRNINVNVVCPGFIASDMTAELGEDMEKKILGTKAEEVAGLVEFLALSPAASYITGQA....................... 299
13 -44.000[QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases  ali follow..  21  26.HLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSRLETVTLDVTKMESIAAATQWVKEHVGDLWGLVNNAGILTPITLCE--LNTEDSMNMLKVNLIGVIQVTLSMLP-LVRRARGRIVNVSSILGRVA-FFVGGYCVSKYGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETY...................................... 238
14 -43.000[I] COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH)  ali follow..  15  3.FLSGKRILVTGVASSIAYGIAQAMHREGAELAFTYQNDGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGNAVTREGFKIAHDISSYSFVAMAKACRSML--NPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASAHCEAVTPIRRTVTIEDVGNSAA--LCSDLSAGISG......................... 242
15 -41.900[R] KOG1611 Predicted short chain-type dehydrogenase  ali follow..  22  1..MSPKSVVVTGSNRGLGFGLVQQFLKDPNHVIATARDVDKATALKG--PRLHILQLSLGSDESIANFAEKVSEIVGELTLLINNAAVMLPYV-TKQKPDRKVVLDLFESNTIGPMMLTQSLVPLIIKASKAIINIASEFLGSISENTSGAYRMTKCAVNQFTKTLSIDLKDDHILTAGICPGMVQTDMSKGKGQ--------LTIEESSSQILAAFNK................................. 232
16 -39.400[Q] KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)  ali follow..  22  42VSAKGLVAVVTGSNCGIGFETVRELNLRKADVYMLCRSEEKANEAKRMLTRLHFIECDLTDFESVRRAAKETLESTDTIDILINNAGIMFQSKHEQTKDGHEK---TWQSNHLGPFLLTELFLPAVKKSSYARIINVSSRIHLKSEKMMKSYRQSKLANVMHARALTKELRKDGVTVNSLHPGVVNTELARNTILNTPGIKQITTSRDGAQTSIFLALGKKIGGISG......................... 297
17 -39.200[IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases  ali follow..  19  1MDLAGKNVVYLGGFGGIGQKCVQELLQRPIKALIFDLNANEQLLAKWKSQDVFYHKLDITQKSDIDAAYKATAERFGHFDVVVNGSGL----------MNDRLVELTIQINLLGVINSTLTALEYMDKAKGGLIVNISSVAGLQPTAIMAIYSAAKTGVTTFTRAMANPYAHSGVGFLTICPGFTDTGLLEDIGNKTTFTYDTQKAEDCARNLVSAIETSKNGTV........................... 236
18 -37.000[I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and related enzymes  ali follow..  18  318KSLCNKVVVVTGAGGGLGKSHAIWFARYGAKVVVIKDPFSVVEEINKLYGEGTAIPDSHDVVTEAPLIIQTAISKFQRVDILVNNAGILRDKSFLKMKDE--EWFAVLKVHLFSTFSLSKAVWPIFTKQKSGFIINTTSTSGIYGNFGQANYAAAKAAILGFSKTIALEGAKRGIIVNVIAPHAETAMTKTIF--SEKELSNHFDASQVSPLVV...................................... 529
19 -36.900[I] KOG1478 3-keto sterol reductase  ali follow..  21  2....RKVVLITGASSGIGLALCKRLLAEDLHLCLACRNMSKAEAVCAALAEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNSQLIWTSSRSAFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLTYG............................................................ 233
20 -26.900[I] COG4982 3-oxoacyl-[acyl-carrier protein] reductase  ali follow..  17  354GLYSSEIAVVTGASKGIAASVAARLLDGGATVIATTSKRALYRDHARYGAALWVVAANMASYSDIDALVEWIGNEAQTPTLLFPFAAPRVIGDLSEAGARS---EIEMKVLLWAVQRLIVGLSKIGTERDVASHVVLPGSPNRGMFGGDGAYGEAKSALDAVVSRWHAESWAARVSLAHALIGWTRGTGLMGHNDVEEAGVTTYSTDEMAAMLL...................................... 596
21 -24.000[S] COG3007 Uncharacterized paraquat-inducible protein B  ali follow..  11  37IANGPKRVLVIGASTGYGLAARITAAGCGADTLGVFFERPG-KFAAQKGLYAKSINGDAFSDEIKQLTIDAIKQDLGQVDQVIYSLASPRRTHPKTKPIGNAVNLRGLDTDKEVIKESIDALLDAGVLAEGAQTTAFTYLGEKITHDIYGSIGAAKKDLDQKVLAIRESLAAHGGDARVSVLKAVVTQASSAIPMMPLYLSLLFKVEGCIEQVY...................................... 310
22 -17.100[C] KOG2865 NADH:ubiquinone oxidoreductase, NDUFA9/39kDa subunit  ali follow..  15  64SSVSGIVATVFGATGFLGRYLVQQLAKMGSQVLVPFRGSEDHLKLMGDLGQVVPMKFDPRDEDSIKAVMA-------KANVVINLIGREYE----------TRNFSFEDANHHIAEKLALVC----EHGGIMRYIQVSCLGASVSSP--SRMLRAKAA--------EEAVLNALPEATIMRPATM-NPWSMFVKIGGGTTKYPVYVVDVAAAIVAALKDDGSSM--GKTYELGGPDVFTTHELAEIMYDMIR 300
23 -16.500[MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases  ali follow..  14  31LANLPPLVTVFGGSGFVGRHVVRMLAKRGYRIRVAVRRPDLAGFLQPNVGQISFAQANLRYRDSIIKAVE-------DADHVVNCVGILAE----------SGRNTFDAVQEFGAKAIAEAA-----RDTGATLTHISAIGADANSQ--TGYGRTKGR--------EAAIHSVLPGAVILRPSII................................................................... 186
24 -16.400[M] COG1089 GDP-D-mannose dehydratase  ali follow..  15  2....TKVALITGVTGQDGSYLAEFLLDKGYEVHGIKRNTERIDHIYQD-PNFHLHYGDLTDSSNLTRILKEV-----QPDEVYNLAAMS------HVAVSFESPEYTADVDAIGTLRLLEA-IRFLGLENKTRFYQASTSELYTPFYPRSPYAVAKLYAYWITVNYR---ESYGIYA-------CNGILFNHESPRRGETF---VTRKITRGLANIAQGLESCLYLG......................... 219
25 -16.300[R] COG2910 Putative NADH-flavin reductase  ali follow..  15  4.......IALIGASGNAGSRILKELSDRGHQVTAIARNPEKI----AALPNVVAKKGDVFDQAALSELLK-------GHDAVISSVHFTASD--------------------------PATLIEAVRASGVQRYLVVGGAGSLEIAPGQRVVDLPKAEATKGAEFLDKLKQEKQLDWTFLSPSAEFVPGERTGKFRIGKDNSRISFEDYAIALADEIEKPQ............................... 193
26 -15.500[R] KOG4288 Predicted oxidoreductase  ali follow..  16  1MK-----IVVLGGSGFLGHNICKLAIAKGYEVVSVSRRGAGGLHNKEPMDDVEWETLDAKDPNSLLPVLR-------DASAVVNSVGILMENNYKKILQNPRGPVSHLAINRDLAIETAKIA----AKANVPVYCYVSAHAA--APGLDPRYIKTKREAEREISKI------SNLRSIFLRPGFMNRATSGALNFLGTASAEPLPSEEVALAALEAISDPS............................... 254
27 -14.800[IE] KOG1430 C-3 sterol dehydrogenase/3-beta-hydroxysteroid dehydrogenase and related dehydrogenases  ali follow..  14  3.NKSGEVLLVTGGSGFLGQHLIKQLLERKEELGIKEIRSLDIVPYKNNIGHRTYVADIGGDLKALSPIFN-------GVDGVFHCAASVKIEYPPN-------YEELERVNVNG----TLAVVDLCIQNNVKRLVYTSCTSVCDNQFLIPGYASSKLRAENISNGAPLHNQKEYLATSAMRAPLT................................................................... 211
28 -13.700[M] KOG1371 UDP-glucose 4-epimerase/UDP-sulfoquinovose synthase  ali follow..  13  90REEGVTHVLVTGGAGYIGSHAALRLLRDSYRVTIVDGAVKTLQQLFPQTGRLQFIYADLGDPLAVEKIFSE------AFDAVMHFAA------VAYVGESTLYPLKYYHNITSNTLGV----LEAMARHKVKKLIYSSTCATYTPQVPINPYGKAKKMAEDM---ILDFSKNSDMAVMIL........................................................................ 269
29 -13.600[Q] COG3321 Polyketide synthase modules and related proteins  ali follow..  16 1761...RDGSYIITGGLGGLGLFFASKLAEAGCRIVLTARSRQTIERLCAAGADIVVECGNIAEPYTADRLVNAATATGLPLRGVLHSAAVVEDATLTNITDE--LIDRDWSPKVYGSWNLHCA----TIGQPLDWFCLFSSGAALLGSPGQGAYAAANSWV----DLFAHWRRAQGLPVSAIAWGAWGEV--GRATFLAEGGEIMITPDEGAYAFEMLVRYDRPYSGY.......................... 1978
30 -13.500[S] KOG2733 Uncharacterized membrane protein  ali follow..  15  1MSGDRLDVIIFGASGFTGKYTVFEAVTRGLRWGIAGRNREKLEAVLKEMGQVPIFIADVNDQASLLEMAKKC-------RIVVNTAG---YRFHGENVVKCCIESGTHHVDVSGEPQYMETMQLRYDQLAREKGVYVVSACGFDSIPAMGVVFVEKNF.............................................................................................. 160
31 -13.300[M] COG1088 dTDP-D-glucose 4,6-dehydratase  ali follow..  14  2.....RKILITGGAGFIGSALVRYIINETSDAVVVAGNLMSLAPVAQS-ERFAFEKVDICDRAELARVFTE------QPDCVMHLAA-------SHVDRSIDGPAAFIETNIVGTYTLLEAARAY-DKKSAFRFHHISTDEVYTPYAPSSPYSASKASSDHLVRAWLRTYG-----------PTLITNCSNNYGPYH-------FPEKLIPLMILNALAGKPLPVYG......................... 218
32 -13.300[S] COG3268 Uncharacterized conserved protein  ali follow..  13  1MSPDKREIVLYGATGFSGKLTAEHLALSTARIALAGRSSERLRNVRALLQDWPLIVADASQPSTLEAMAGRA-------QVVLTTVG---YTRYGLPLVAACARTGTDYADLTGELMFCRNSIDLHHKQAAATGARIILACGFDSVP-------SDLNVYQLYRRVIEDRTGELCDT........................................................................... 169
33 -13.300[G] KOG1203 Predicted dehydrogenase  ali follow..  17  121...TSGIILVAGATGGVGRRIVDILRKRGLPVKALVRNEEKARKMLGP--EIDLIVADITKENTL------VPEKFKGVRKVINAVS..................................................................................................................................................................... 196
34 -13.300[MG] COG0451 Nucleoside-diphosphate-sugar epimerases  ali follow..  15  3.......YLVTGTAGFIGFYVAKRLLDAGHFVTGFDGKEKRHAILARS-NGFRAEIGMLEDTDALKRAAEAA-----EPEIIIHLAAQ------AGVRYSLENPRAYIDSNLIGSFNM----LELARSLKVKHLMLASTSSIYKADEPMTLYAATKKSMELMAHSYAHKLPTTAFRFFTVYGP-------------------WGRPDMAPIKFVDAVSNGQPIDIYG......................... 210
35 -12.800[V] KOG1502 Flavonol reductase/cinnamoyl-CoA reductase  ali follow..  12  6...EGKVVCVTGASGYIASWLVKFLLSRGYTVKASVRDPSDPKKTQHLVSRLHLFKADLLEQGSFDSAID-------GCHGVFHTAS---------FNDAKDPQAELIDPAVKGTLNVLNSCA---KASSVKRVVVTSSMAAVG--ASKMWYVLSKTLA---EDAAWKLAKEKGLDIVTINPAMV-LNLINGAKTFPNLSFGWVNVKDVANAHIQAFEVPSA.............................. 247
36 -12.500[G] KOG0747 Putative NAD+-dependent epimerases  ali follow..  15  3.SYTPKNILITGAAGFIASHVANRLIRSDYKIVVLDKNLKNLNPSKHS-PNFKFVKGDIASADLVNHLLIT------GIDTIMHFAA-------THVDNSFGNSFEFTKNNIYGTHVLLEACIRRFIHVSTDEVYGETDEDALVQLLPTNPYSATKAGAEMLVMAYGRSY---GLPVITTRGNNVYGP--------------NQFPEKLIPKFILLAMRGQVLPIHGDGSNVRSYL................ 226
37 -12.100[M] COG1087 UDP-glucose 4-epimerase  ali follow..  18  2......TILVTGGAGYIGSHTCVQLIEAGHEVVVVDNFDNSHPEALHRIRAPRREPGDIRDRALMEQMIKR------KCTAVIHFAG------LKAVGESSEKPLLYYDCNVLGTLRL----LQAMEATGVKKLVFSSSATVYQPLSATNPYGRTKLVIEDMLRDLYNSDNSWAIAIL.......................................................................... 174
38 -11.400[E] COG1748 Saccharopine dehydrogenase and related proteins  ali follow..  12  1MK---KNVLIIGAGG-VAQVVAHKCAQNSGDIHIASRTVDKCRKIVESVRELEAHALDALDVEATKALIVST-----GSQIVINVGSAFVNMSVLRACMD-----------------------------TGVAYMDTAIHEEPNKICETPPWYGNY------EWKRAAECKEKGITAILFDPGVVNA................................................................. 158
39 -11.400[R] COG1090 Predicted nucleoside-diphosphate sugar epimerase  ali follow..  11  33.....MKIILTGATGFVGCSLVPLLHQQGHELTLLVRSVSKAQRLPGSFPQLKAIAYEATKSGDWQKVVD-------GQDAVINLAGEPISERWTE-----AYKAEIFDSRKLGTEKLVEAI----KADRKPQVMISGSAIGYYGTSETATFTESSKPGDDFLENAAHQVEQLGVRLVVFRIGIV................................................................... 206
40 -11.000[GO] KOG1431 GDP-L-fucose synthetase  ali follow..  12  5..QGSMRILVTGGSGLVGKAIQKVVADGAGLPGEDWVFVSSKD-------------ADLTDTAQTRALFEKV-----QPTHVIHLAA-----MVGGLFRNIKYNLDFWRKNVHMNDNV----LHSAFEVGARKVVSCLSTCIFPPHNSNFGYSYAKRMIDVQNRAYFQQY---GCTFTAVIP----TNVFGPHDNFNIEDGHVLPG--LIHKVHLAKSSGSALTVWG......................... 209
41 -10.600[GM] KOG1429 dTDP-glucose 4-6-dehydratase/UDP-glucuronic acid decarboxylase  ali follow..  16  26FFQSNMRILVTGGAGFIGSHLVDKLMQEKNEVIVADNSKDNLKKWIGHPR------FELIRHDVTEPLFV-------EVDQIYHLACPASPIFYKYNPVK------TIKTNVIGTLNMLG-----LAKRVGARILLTSTSEVY-PIGVRSCYDEGKRVAETLMFDYHRQIEIRIARIFNTYGPRMNID------------------GRVVSNFIAQALRGEALTVQK......................... 234
42 -10.400[MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases  ali follow..  14  279..ITEKSVMVTGAGGSIGSELCRQILAQKKTLVLFELNEYNLYTIDQELQKIVAALGSVQRENRVKKLMQA------QVETVYHAAAYKHVPLVEDNVIE-------IRNNVFGTLACANAAIEAGVKN----FTLISTDKAVRPT---NIMGASKRMAELVLQALADKNSTTIFTMVSVVPPVTVTH--------PDIIRYFMLIPEAAQLVIQALDMGEPVKIVDLAKRMIHLM................ 528
43 -9.800[E] COG0169 Shikimate 5-dehydrogenase  ali follow..  10  119VLLKGATILLIGA-GGAARGVLKPLLDQQASITVTNRTFAKAEQLAELVAAYGEVK------------AQAFEQLKQSYDVIINSTSASLDGELPAIDPVIFSSRSVCYDMMYGKGY--TVFNQWARQHGCAQAIDGLGMLVGQAAESFMLWRGLRPGTKQILRELRKNLEGA............................................................................... 277
44 -9.560[I] KOG1221 Acyl-CoA reductase  ali follow..  16  19..YANKTILITGATGFMGKVLVEKLLRS-NVIYLLIRTKVRKEQYFKCVDKVRVVKGDLLSANDTNTLAS-------NVEVVFHCAANVRFD---------QPLRPMVMMNVVGTLKVLRLAMSQLQ-----ALVHVSTSYCQCNESVLEAYPAP---TYAYSKALSEDLYNNKLPIIITRPSIVTAAIHE............................................................. 249
45 -9.500[Q] KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes  ali follow..  14  643...NGQYFLLTGATGYFGRRFLEYLVKLNISVVCLVRESSRLISLVPSLENIIVWAAHVEEIR--DAKWEFLVEN---VSRIYHMAAEVHW---------MKSYQELRPANVLGTKTVLE-----LSVMGPKALYFISGGGQQTQSAKASGYALSK-----VAELLCRKISDLGHPLIYVVATALRMGIWPQSDESQSLVFHISTTDALCMTLTQILEKEADAY............................ 883
46 -9.200[M] COG1091 dTDP-4-dehydrorhamnose reductase  ali follow..  13  3.......LAVTGRNGQVVSALQALA-GADLEIVTLGRPE-----------------LDLVRPENVLQALREAKP-----DVVVSAAA------YTAVDKAESEPDIAFAVNRDGAKAVAQAA-----KELGVPVIHLSTDYVFDGSKATAIYGRSKLK.............................................................................................. 130
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.