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Query: [R] COG4032 Predicted thiamine-pyrophosphate-binding protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MYVVNPEEKVIEIMKQTGIDLAATLPCDRIKNLLPLVSENFPEIKLTREENGVGICAGIYLAGGKPMMLIQSTGLGNMINALESLNVTCKIPLPILASWRGVYKEGIEAQVPLGAHLPSILEGAGLTYTIIGETEKLPLLENVILDAFENSRPHIALVSPKVWEASECCAWQAAGMPIKPEIMERTCRFSLTSGTLKPFMLLast
1 -77.000[R] COG4032 Predicted thiamine-pyrophosphate-binding protein  ali  100  1MYVVNPEEKVIEIMKQTGIDLAATLPCDRIKNLLPLVSENFPEIKLTREENGVGICAGIYLAGGKPMMLIQSTGLGNMINALESLNVTCKIPLPILASWRGVYKEGIEAQVPLGAHLPSILEGAGLTYTIIGETEKLPLLENVILDAFENSRPHIALVSPKVWEASECCAWQAAGMPIKPEIMERTCRFSLTSGTLKPFML 201
2 -35.700[EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]  ali follow..  15  34DTTLTTAQLMVQCLENEGVEYIFGLPGEENIRFVDALDSTIRFIVVRHEQGASFMADIYGRVTGKAGVCISTLGPG-AINLLLGTADAFSTPLVAISAQ--VSLNRIYKETHQVVDLLNMFKPVTKWAEMIIGSAAIPEMMREAFEKAQTSRPVYLCVPEDVESISGLTGLRPDEADSMPGSAQITRAAQVLQEATKPIIL 240
3 -34.200[EH] KOG1185 Thiamine pyrophosphate-requiring enzyme  ali follow..  10  69GSNMDGASITAAALKSQGVEYMFGVVGFPVIEVGMAAAHGIKYIGCRNEQAAAYAAQAMGYLTGKPVALLVVSGPG-ILHAIGGLANATCWPVVCIGGT--ADVDLENRGAFQEWSQQESVRNSCKHVSRPTSLHTIPAIEKAVRCAMYGRGAVYVDLPGNLVLTSTEEEVPLPAPVSIPPIAEIEKAIDTLKSAKKPLVI 277
4 -34.200[EH] KOG4166 Thiamine pyrophosphate-requiring enzyme  ali follow..  13  84FVGKTGGEIFHDMMLKHNVKHVFGYPGGAILPVFDAISPHFEFILPRHEQAAGHAAQAYSRVTKKPGVVLVTSGPG-ATNVITPIADALGTPLVVFSGQ--VATSAIGSDAFQEADMVGISRSCTKWNVMVKDVADLPRRIDEAFEIATSGRPVLVDLPKDVTASVLKEPKEVLEEGSKNVTAKIDRVANLLKLAKKPVIF 301
5 -34.100[R] COG3960 Glyoxylate carboligase  ali follow..  11  1MAKMRAVDAAMYVLEKEGITTAFGVPGAAINPFYSAMHGGIRHILARHVEGASHMAEGYTRATGNIGVCLGTSGPA-GTDMITALYSASSIPILCITGQ--APRARLHKEDFQAVDIEAIAKPVSKMAVTVREAALVPRVLQQAFHLMRSGRPVLVDLPFDVQVAEIEFDPDMPVYKPAASRMQIEKAVEMLIQAERPVIV 209
6 -33.700[GHR] COG3961 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes  ali follow..  12  1MSEITLGKYLFERLSQVNCNTVFGLPGDFNLSLLDKLYEGMRWAGNANELNAAYAADGYARIKGMSCIIT-TFGVGEL-SALNGIAGSYHVGVLHVVGVPSISSQAKQLLLHHTTVFHRMSANISETTAMITDIANAPAIDRCIRTTYTTQRPVYLGLPANLVDLNVPAKLLETPIDLSLKPNDVRTVVELIKDAKNPVIL 217
7 -33.300[EH] KOG1184 Thiamine pyrophosphate-requiring enzyme  ali follow..  12  42YCDATLGRHLARRLVQAGVTDVFSVPGDFNLTLLDHLEPDLNLIGCCNELNAGYAADGYARSRGV-GACVVTFTVGGL-SVLNAIAGAYNLPLICIVGGPNSNDYGTNRILHHTSQELRCFQTVTCYQAVVNNLDDAHEIDKAISTALKESKPVYISVSCNLAAIPHHTSLAPRLSNKMGLEAAVEATLEFLNKAVKPVMV 259
8 -28.200[E] COG3962 Acetolactate synthase  ali follow..  8  3TIRLTAAQAMVRYLAAQMNEHVWAIFGGNVAGIGEALRDELPTYRGQNEQSMAHAAIAYSKQLRRRRAMAVTSGPG-AANMVTAAALAHRLPVLLIPGDVFANRQQLEDFGDGTMTVNDCFRPVSRYFDRIMRPEQLLTLPRAMRTMTDPADPVTLAFCQDVQAEAYDYPVSFFEKRIEPDVVEFEEALAALKAAKNPVIV 232
9 -24.300[H] COG1165 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase  ali follow..  12  1MSVRRWAAVILEALTRHGVRHICIAPGSRSTPLTLAAAENFIHHTHFDERGLGHLALGLAKVSKQPVAVIVTSGTA-VANLYPALIEAGGEKLILLTADR--PPELIDCGANQAIRQPGMFASHPTHSISLPRPTQDIPARWLVSTIDHHAGGVHINCPFAQQRLGDWWQDDKPWLREAPRLESEKQRDWFFWRQKRGVVV 225
10 -20.400[C] COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits  ali follow..  13  15..FLLGNEAIARGAIEAGIDVFAAYPGTPSSEIADTLSDDFYMEYSANEKVAFEVAVGASLAGKRAMATMKHVGVNVAADPLFSFAYV-GARGGFVLVTADDPSMHSSQNEQDNRWYLPVVEPSSV-------QEAKDYAKLCFDLSEKFGLPMILRSYTRLSHASGVVELGK............................ 191
11 -16.500[C] COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit  ali follow..  16  4MKTMDGNTAAAHISYA-FTDVAAIYPITPSSPMAEHVDEKVKIMEMQSEAGAAGAVHGSLQAGALTTTYTASQGLLLMIPNM-YKIAGELLPGVFHVSARALATHSLNIYGDHQ----DVMAARQTGCALLSVQEVMDLSAVAHLVAIKGRVPFINFFDGFRTSHEIQ................................. 180
12 -10.200[C] KOG1182 Branched chain alpha-keto acid dehydrogenase complex, alpha subunit  ali follow..  9  174.AALSPDDVVLPQYREPGVLLWRGFTLEEFAN-IHYGSNRLNYFTIS--ATQLPQAAGVGYSDKKNACTVTFIGDGGTSEG-LNFAAVMEAPVVFICRNNGWAISTHISEQFRSDGIVVKGQAYGIRSIRVDGNDALSAVRSAREMAVTEQRPVLI--------EMMTYRVGHHSTSDDSTKYRAADEIQYWKMSRNPV.. 389
13 -9.510[HI] COG1154 Deoxyxylulose-5-phosphate synthase  ali follow..  13  317.GLPGYSKIFGDWLCETA-SKLMAITGSGMVEFSRKFPDRYFDVAIA-EQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVIHDVAIQKLPVMFAIDRAGIVGADGQTH--QGAFDLSYLRC--IPDMVIMTPSDENECRQMLFTGYHNDGPTAVRYPRG----------NAQGVALTPLEKLPIGKGLVKRHGEKLAIL 509
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Harder T, Kolodny R, Sitbon E, Li Z, Godzik A. Using an alignment of fragment strings for comparing protein structures. Bioinformatics. 2007 Jan 15;23(2):e219-24.