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Query: [R] COG4076 Predicted RNA methylase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRFRVTPYHGNLLGDHERLAAFREAISSRARGLTYDLGAGSGILSFFASEYADRVIAIERDPKIAACAGENLSGLDNVSVVNEDALHYEFSAADTIICEMLDTALIDEEQVPVLRRALKFLRNDGTVIPQAVFNAAEPVTVNFENIMYDENLSQPSSGPMRVYDRVEFRGNLPEIFRGSLKLQASSPFNAIRIISFTLTAPGIICGPTPMMNPPLIIPLEETGDKGEVEIKLSYRMGGGLDSVEASIILast
1 -85.800[R] COG4076 Predicted RNA methylase  ali  100  1MRFRVTPYHGNLLGDHERLAAFREAISSRARGLTYDLGAGSGILSFFASEYADRVIAIERDPKIAACAGENLSGLDNVSVVNEDALHYEFSAADTIICEMLDTALIDEEQVPVLRRALKFLRNDGTVIPQAVFNAAEPVTVNFENIMYDENLSQPSSGPMRVYDRVEFRGNLPEIFRGSLKLQASSPFNAIRIISFTLTAPGIICGPTPMMNPPLIIPLEETGDKGEVEIKLSYRMGGGLDSVEASII 248
2 -52.900[OKT] KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes  ali follow..  19  223.SYAGNDIHFLMLNDSVRTEGYRDFVYHNKGKTVLDVGCGTGILSMFCAKAGAKVYAVDNSDIIAISNAFENGLADQITFIRGKIEDISLGKVDIIISEWMGYALTFESMIDSVLVARRFLAPSGIMAPSETRLVLTATTNTEEPIDFWSDVYGFKMNGMKDFARFNMHTCKVQDVPFSLIIDNEGPLCAFTLWFDTYFTTKRTQPPTHWKQCVLLLR--FLQKGTRVEGTISFSKNKKNNDLDISV. 527
3 -39.700[D] KOG0822 Protein kinase inhibitor  ali follow..  14  369.ENLDSGVYNTFEQDQIKYDVYGEAVVGALTVVIYLLGGGRGPIGTKILKSERKLYIVEKNPNAIVTLKNVRTWKRRVTIIESDMRSLPGEQPDIIVSELLGSFGDNELSPECLDGVTGFLKPTTISIPQKYTSYVKPIMSTHIHIPYLSRAIPSHGRGEPELDEDEMNSSNERSDSIEFVMDRNADLMGFAGYFDLQLYKTVMLSIEPVSWFPAVIPLRDVGEGDRISLKIDRKVDNTGVWYEWHV. 708
4 -21.000[R] KOG2899 Predicted methyltransferase  ali follow..  22  94..............HDIRLDVLGTQPDLFRNKQLLDIGCNSGHLSIQIARKVKSLVGLDIDRGLINDAQKTVSHLKHGNYVLEDDVLLEIEQFDVILCKWIHLNFCDSGLKQAFRRMYLQLRPGGKLI........................................................................................................................ 230
5 -20.300[R] COG4106 Trans-aconitate methyltransferase  ali follow..  15  1MAWSAQQYLKFEDERTRPARDLLAQVPLERVLNGYDLGCGPGNSTELLTDRVNVITGIDSDDDMLEKAADRLP---NTNFGKADLATWKPAKADLLYANAVFQWV--PDHLAVLSQLMDQLESGGVLA........................................................................................................................ 126
6 -19.300[R] KOG2361 Predicted methyltransferase  ali follow..  18  79..................DKEWNSYFSVSGKSVILEVGCGAGIFPLIATYPDIFVYACDFSPRAVELVKAHDEYTETACDLTGDGLDKHISSVDIVTMIFVLSAVSPEKMSSVLQNIRKVLKPNGCIL........................................................................................................................ 197
7 -19.300[R] KOG1541 Predicted protein carboxyl methylase  ali follow..  12  36..................TLRALELLNLQPCSFILDIGCGSGLSGEILTQEGDVWCGLDISPSMLATGLSRELEGDLMLQDMGTGIPFRAGSFDAAISISAIQWLCNAD--TSYNDPKQRLMRFFNTL........................................................................................................................ 144
8 -18.600[J] COG2264 Ribosomal protein L11 methylase  ali follow..  16  159..............................DKTVIDFGCGSGILAIAALKLGASAVGIDIDPQAILASRNNNGVADRLQLFLSEDKPAD-LKADVVVAN-----ILAGPLKELYPVIRQLVKPNGVLGLSGI.................................................................................................................... 258
9 -18.500[A] KOG1975 mRNA cap methyltransferase  ali follow..  12  132.IANRAKRNLSPIIKLRNFNNAIKYMLIDKGDVVLELGCGKGDLRKYGAAGISQFIGIDISNASIQEAHKRYRSMRQVVLITGDCFGESLFPCDIVSTQFCLHYAFEEKARRALLNVAKSLKIGGHFF........................................................................................................................ 280
10 -18.500[I] COG3963 Phospholipid N-methyltransferase  ali follow..  16  36.............TSSITAKKMASVINPHSGLPVLELGPGTGVITKAILARGESLTAIEYSTDFYNQLLRS---YPGVNFVNGDAFDLDGQMFDSVISAVPMLNFPMAARIKLLDELLKRVPHGRPVV........................................................................................................................ 157
11 -18.000[H] KOG1270 Methyltransferases  ali follow..  14  62..............NDLRVPFIRDNLLKTLGMKILDVGCGGGLLTEPLGRLGASVIGIDPVDENIKTAQCHKSFDPRIEYRVCSLEEITAETFDAVVAEVVEHV---IDLETFLQCCCQVLKPGGSLF........................................................................................................................ 190
12 -17.800[R] KOG3010 Methyltransferase  ali follow..  14  13..............LDAR-PRYPIDWFKKIHKFAWDVGTGNGQAAIGLVEHYENVVATDINEAQLQRAIKHSRISTPTTISEDEMVDLLGGSVDLIVAHFFDLNVFYNV-------AKRVLRKEGGLI........................................................................................................................ 133
13 -17.400[R] KOG1331 Predicted methyltransferase  ali follow..  12  17..YSRLATYQQKEHKPSSPRIWPRVRQQSAGSIILDVGCGEAKY----TSQKSHVIGFDTCSEVLSSSKK-----DDIDLCLADAINIPIRDVDAILN-VIHHLATTARRRQVLQECSRCLRIGGQML........................................................................................................................ 140
14 -17.300[J] KOG3420 Predicted RNA methylase  ali follow..  17  48..............................GKKLIDIGCGCGMLMTTAATELETVLGVDIDDEALKICSRNAEVQDRCELLQADISDLPRGTFDVAVIN-FGTKNNAGIDMQFVQIGLQMVRPGGSVF........................................................................................................................ 155
15 -17.200[J] COG0030 Dimethyladenosine transferase (rRNA methylation)  ali follow..  17  30.........QHILKNPLVAQGIVDKADLKQSDTVLEVGPGTGNLTVRMLEKARKVIAVEMDPRMAAEITKRVQKEKKLQVVLGDVIKTDLPYFDVCVSNT---YQISSPLVFKLLQQRPAPRAAILMFQREFALRLVA.............................................................................................................. 159
16 -17.100[A] KOG0820 Ribosomal RNA adenine dimethylase  ali follow..  17  36.........QHILKNPLIINSIIDKAALRPTDVVLEVGPGTGNMTVKLLEKAKKVVACELDPRLVAELHKRVQVASKLQVLVGDVLKTDLPFFDTCVANL---YQISSPFVFKLLLHRPFFRCAILMFQREFALRLVA.............................................................................................................. 165
17 -17.100[R] COG3897 Predicted methyltransferase  ali follow..  16  75.............................CGKRVLDFASGSGLVAIAAAKAGAKVLAADIDPWTETAIRLNAALNGVDIGFTGLDLVGKPVDADVLLGDVFYDRAFADLLVPWF---VELTEKGMIVL........................................................................................................................ 172
18 -17.100[J] COG1889 Fibrillarin-like rRNA methylase  ali follow..  19  72.......................KLVPIKEGTHILYLGAASGTTPSHISDINGLIYSVEFSPRVFREFMEKLVDQRNVVPILGDARFPYQYAHYVKGVDVVYIDVAQAQAKILADNADYFLKPGGHVM........................................................................................................................ 182
19 -17.000[R] KOG1271 Methyltransferases  ali follow..  15  51.....................LNEEKIDKEASRVLDLGCGNGMFLVGLANEGGDLTGVDYSPKAVELAQNIAEDNKSITYKVADLTQPQNEQFDVVHDKGTYDAVSKEKRALYLDTVEKLLRTADSLF........................................................................................................................ 168
20 -16.700[R] COG4123 Predicted O-methyltransferase  ali follow..  23  35..............DSVLLSRFPRF---PKKGLIVDFCAGNGAVGLFASRTQAQILSVEIQERLADMAERSNGLEEQMQVICDDLKNIQGSKVDMILCN-LARHEITTNLEEICRSAQSILKSNGRL......................................................................................................................... 170
21 -16.700[IR] KOG1269 SAM-dependent methyltransferases  ali follow..  11  94FHFSRFYKGEAFAQSIAREHYLAYRMGIKPGSRVLDVGCGVGGPAREITETGCNLVGLNNNDYQISRCNNYANLDKKQVFVKGDFMHMPFETFDYVYA--IEATVHAPSLEGVYGEIFRVLKPGGVFG........................................................................................................................ 226
22 -16.700[H] COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase  ali follow..  21  33..............NPLRVNWIDERA-GLAGKKVLDIGCGGGILSEAMAQRGASVTGIDMGEAPLAVARLHQLESGAVDYRQITAEQMMPGQFDVVTCEMLEHV---PDPASVIRACHRLVKPGGQVFLSTIN................................................................................................................... 152
23 -16.500[J] COG2263 Predicted RNA methylase  ali follow..  26  45............................DLDESVQDLGCGTGILAIGAKLLGAKVVGYDTDPKALEVARKNAERLGEVEFVCSDIKKVS-GHVKTTLMN..................................................................................................................................................... 116
24 -16.100[S] COG1255 Uncharacterized protein conserved in archaea  ali follow..  14  14..............................KGKVIEVGIGFYTIAKRLKELGFDVLAIDINKDAVVNAKN-----SGLNAEVDDIFNPNIMGAKAIYS-------PTPEMMNYILKISKAVKVPAYIV........................................................................................................................ 105
25 -16.000[H] COG2242 Precorrin-6B methylase 2  ali follow..  21  53...........LSKREVRLLII-SALQLKEESIIWDIGAGTGTIPVELALLRSRIVAVERDEEVAGLIRRNCEGVTNVTVHEGSAPDC-IAHPTHICIE-------GRPIKQILQETWAHLAPGGRLVATANNL.................................................................................................................. 175
26 -16.000[R] KOG4300 Predicted methyltransferase  ali follow..  13  303................SDYKMKLFDNLVGKAEKVLEIGIGTGPFKYYTDIPNVSVIGIDPNAKMESYARKSATEAGEFTFVHALGESIPLESVDAVVGTLVLCSV--TDVTQTLKEIKRILRPGGIYI........................................................................................................................ 419
27 -15.700[R] COG2521 Predicted archaeal methyltransferase  ali follow..  20  100LMIDGITMHSVLENPLLLTSR------ERAWGRVFECCTGLGYTAIEALKKGAHVITVEVDPHVLTLASLNPYSSPAVDVILGDVQTVRDSSIDFIIHDPPRLSHATQRLYALYREFYRILKRGGGVF........................................................................................................................ 234
28 -15.600[A] KOG3045 Predicted RNA methylase involved in rRNA processing  ali follow..  15  204.....................IKTIKKIPKTAIIGDFGCGEGKL---AQSVPNKVYSMDLVA-------------ARSDIIACNITDTPLQTLDVAVY----LSLMGTDLNEFFLEANRVLKLHGTVY........................................................................................................................ 293
29 -15.300[R] COG4798 Predicted methyltransferase  ali follow..  15  93.............RDAARRGEILAMAELKPGDTVVDYIMGGGYFTRIISGAQGVVYAYQPAEFIRFAARYGESLKANSKPLDGPITALDLPNVDAVITDMHLKPFPTDTAAKANAEIFKSLKPGGVFL........................................................................................................................ 223
30 -15.100[J] COG2813 16S RNA G1207 methylase RsmC  ali follow..  19  227..................ARFFMQHLPENLEGEIVDLGCGNGVIGLTLLDKNAKVVFVDESPMAVASSRLNVETNDRCEFMINNASGVEPFRFNAVLCN-QQHALTDNVAWEMFHHARRCLKINGELY........................................................................................................................ 347
31 -14.800[J] KOG3191 Predicted N6-DNA-methyltransferase  ali follow..  21  39..........FLLIDAIEKDI--KEIRSRDPKLVLEIGCGSGVVSTFVNQGNVTSVATDLNPHALDVTLETAKLNDKIDVVRTDLFA-LLGKVDVLLFNYAGGRTGRSTLDRLLPRVPELLSPRGVFY........................................................................................................................ 178
32 -14.700[O] COG2518 Protein-L-isoaspartate carboxylmethyltransferase  ali follow..  23  56........GGQNMLPPRVEARVLQELAVRKHEDVLEVGAGSGYMAALLAHRGRHVTTVDIAPELVAFARDNLARNTNVDVVQGDAGQWGNSLYDVIC--------VSGSVPAVPESLLAQLKVGGRLS........................................................................................................................ 170
33 -14.500[QR] COG0500 SAM-dependent methyltransferases  ali follow..  12  84.EYAYFSSFATSWVSHAKCDEITERLELNDNSFVVEIASNDGYLLQHFLPKNIPILGIEPAANVARTAIAKGVPTLVDFFGSRLALEMIGEKADLIIGNNVLAQV--PDLNDFVRGMQLLLKPEGLLRWNSRISSI................................................................................................................ 220
34 -14.200[R] COG4976 Predicted methyltransferase (contains TPR repeat)  ali follow..  17  133..................AAVIGRVNGGGRFRHVTDLGCGTGLFGERIRDRADFLEGFDLSANMLAKAEARLAQADLSLAPEDSGVFGALEQADLVSA--ADVLMYLGNLEGVFVIADRLLAPGGLFA........................................................................................................................ 247
35 -14.100[J] KOG2915 tRNA(1-methyladenosine) methyltransferase, subunit GCD14  ali follow..  19  225........RGTAITFPKDINMILSMMDINPGDTVLEAGSGSGGMSLFLSKAQGRVISFEVRKDHHDLAKKNYK-PDNVDFIHKDISGIKSLTFDAVALDMLN---------VTLPVFYPHLKHGGVCAVNITQV.................................................................................................................. 366
36 -14.000[V] COG3510 Cephalosporin hydroxylase  ali follow..  9  61...........CWKSVSDMWNYQEILSELQPSLVIEFGTRYGGSAVYFANIPFKVLTVDNSHKALDPRARR---EPDVLFVESSSTDPAIPGKIFAILD-------MNHVLAEMKLLRPLLSAGDYLV........................................................................................................................ 188
37 -13.900[L] COG0742 N6-adenine-specific methylase  ali follow..  20  36.............TDRVRETLFNWLAPVIVDAQCLDCFAGSGALGLEALSRYAGATLIEMDRAVSQQLIKNLATAGNARVVNSNAMSFKGTPHNIVFVDPPFRRGLLEETINLLE-DNGWLADETLIY........................................................................................................................ 155
38 -13.900[J] COG2519 tRNA(1-methyladenosine) methyltransferase and related methyltransferases  ali follow..  21  72........RGPQIVHPKDAALIVAYAGISPGDFIVEAGVGSGALTLFLANIEGRVVSYEIREDFAKLAWENIGFDDRVTIKLKDIYEIEEENVDHVILDLPQ---------RVVEHAAKALKPGGFFV........................................................................................................................ 191
39 -13.800[J] COG2890 Methylase of polypeptide chain release factors  ali follow..  19  125..................IQNRFEPWLTEEPTRIMDLCTGSGCIAIACANAEAEVDAIDISVDALNVAEQNHGLEQQVFPIRSDLRDLPQEQYDLIVTDSLPSEFRHEPELGILANAPLYLKENGILV........................................................................................................................ 263
40 -13.700[M] COG2230 Cyclopropane fatty acid synthase and related methyltransferases  ali follow..  9  156KQYSCAYFDPP--AQLAKKRHIAAKMLVKEGDKVLDIGCGWGGMGLYLARLKANVTGVTLSEEQHAIANQRAGLADRAKFELTDYRNIN-DKFDRLVSVGMFEHVGVGHFAEYFQHVARLMKPDGVFLLHAIGRS................................................................................................................. 297
41 -13.300[R] COG2520 Predicted methyltransferase  ali follow..  18  102MDIRKVFFNPRLYWERARVASKVLP-----GESVLIPFAGVGPFVLPSAGKGAAVCAIEINPDACACLKENNRLEGQVTVIQGDAEYILSHPDSLTNEGFEVPENGFDRAIHFLGEVSGNVRKEGKI......................................................................................................................... 234
42 -13.000[R] KOG2920 Predicted methyltransferase  ali follow..  18  187.............................AGKKVLDLGCGSGLLGITAFKGGSKIHFQDYNSMVIDEVTLPNTQLYKCRFFSGESSEKLFVKYDLILSETIYNPDYYSNLHQTF---LRLLSKNGRVL........................................................................................................................ 320
43 -12.800[R] COG2933 Predicted SAM-dependent methyltransferase  ali follow..  15  210............................ANGMWAVDLGACPGGWTYQLVKRNMWVYSVDNGPMAQSLMDT-----GQVTWLREDGFKFRPSNISWMVCDM---VEKPAKVAALMAQWLVNGWCRETIF........................................................................................................................ 303
44 -12.600[A] KOG2793 Putative N2,N2-dimethylguanosine tRNA methyltransferase  ali follow..  14  69.............................RRRRGIELGTGCGVAGMAFYLLGLTEIVLTDIAPVMPALKHNLKRNKTALGKSLKTSIVY-PPFDLVIADVVYIEESVGQLVTAM---ELLVADDGAVL........................................................................................................................ 175
45 -12.400[H] COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis  ali follow..  18  35.KYDVMNDLMSFGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAKFSRMTGKVILADINDSMLKMGREKIGVIGNVEYVQANAEALPFPTFDCIT---ISFGLRNTEKEKALRSMFRVLKPGGRLL........................................................................................................................ 167
46 -12.300[R] KOG2940 Predicted methyltransferase  ali follow..  11  75........KNDSFVDAVADNLLDRLEDCKKSPTAFCLGGSLGAVKRLLRGRGEKLIMMDTSYDMIKSCRDAQDNSIETSYFVGDEEFLPVSSVDLIISSLG------NDLPGSMIQCKLALKPDGLFL........................................................................................................................ 201
47 -12.300[H] KOG1540 Ubiquinone biosynthesis methyltransferase COQ5  ali follow..  13  71..FSSVANRYDLMNDFINKLDAGKRPNSTTPLNFIDVAGGSGDIAFGLLDHESTMDIVDINPDMLKEGEKRAFKDPRVRFLVSNGEKLEEIDSDSKDIYTVSFGIRNTDIQKGLNTAYRVLKPGGIFY........................................................................................................................ 224
48 -12.100[R] COG1568 Predicted methyltransferases  ali follow..  10  132.............ETTVARVILMHTRGDLENKEIFVLGDDDLTVALMLSGLPKRIAVLDIDERLIKFIEKVADELNDIEIFTFDLRKPLPDKFDTFITD--------KAIRAFVGRGIATLKGPRCAG........................................................................................................................ 250
49 -12.100[R] KOG2904 Predicted methyltransferase  ali follow..  18  174..........GVLIPRPETELIVDMVEELVTRIWADLGTGSGAIAIGIAKVRGRVIATDLSPVAIAVAGHNYSLEGMIEVREGSWFE-LEGKLVGLVSNLQAEVGRHEPKLALCHGASRMLQPGGFFV........................................................................................................................ 331
50 -12.000[R] KOG1227 Putative methyltransferase  ali follow..  14  168YDATKRVFENSKKAEMKRISKWSCQ-----GQTIVDMYASLGYYTLTFLVSCKQVVAIDWNDEILESLIRSNNVDDRLLVIHGDCRRVCPDTADRVYLGLL------PSCRAHWLAACKALKPEGGIV........................................................................................................................ 290
51 -11.800[Q] KOG1663 O-methyltransferase  ali follow..  9  73...........MTTSADEGQFLNMLIKLVNAKNTMEIGVYTGYSLLATALADGKILAMDVNRENYELGLEKAGVAHKIDFREGPALPVNHGTYDFIFVD-------KDNYINYHKRLIDLVKIGGVIGYDNT.................................................................................................................... 203
52 -11.800[L] KOG2671 Putative RNA methylase  ali follow..  18  203..............DAEMAFLMANQAKATSGKLVYDPFVGTGSILVSAARFGAMTMGADIDIRVVRDGRGPDGLPMPVALLRMDNNVPPWEIFDAIICD------LVECVHDLLHLAARMLVMKGRLVP....................................................................................................................... 372
53 -11.700[E] KOG2352 Predicted spermine/spermidine synthase  ali follow..  16  9.SFTDPAYWKNFFAKRKSPNSLSNVIDKKPKDTFLQLGCGNSELATQLYDNGHCIHSIDVEPSVIATQIRKNKERLGMTFETGDAANLSMEAHTIVIDKTLDALLPPSAVTKMFEEVHRVLASGGRYI........................................................................................................................ 155
54 -11.700[R] KOG2497 Predicted methyltransferase  ali follow..  15  170.............................ANKACFEVGSGVGMVGICLAHVKAKVILTDGDLLTLSNMKLNLERNTRVKCTTASESELSQYRPDIVLADVIYDPSCLPHLLRVL---VALLKNPP........................................................................................................................... 286
55 -11.700[J] COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase  ali follow..  20  171FRYRQIEGGFTQPNAAVCQKMLEWACGEGLGGDLLELYCGNGNFTLPLSEKFERVLATEISKTSVGAAQWNANGIGNIKIARLSAEEFTEAAFSTIFVD------IDEETLKLVSQFDNII............................................................................................................................... 314
56 -11.600[A] KOG0821 Predicted ribosomal RNA adenine dimethylase  ali follow..  14  32......QLSQNFLLDLRLTDKIVRKAGNLTNAYVYEVGPGPGGIT-ILNADVAELLVVEKDTRFIPGLQMLSDAAGKLRIVHGDVLTFKVEKA........................................................................................................................................................... 120
57 -11.400[R] KOG3115 Methyltransferase-like protein  ali follow..  17  74.......................FDVESNKKVEIVDIGCGYGTVALGPQFPDTLVLGMEIRMQVSDYLKEKIQALKNISVLRMNCQKFQLSKMFFCFPD-----IITSTLASEY---AYFIRPHGTL......................................................................................................................... 204
58 -11.200[R] COG0220 Predicted S-adenosylmethionine-dependent methyltransferase  ali follow..  16  20...........VVENPADFKGRWSERFGNDHPIHIEVGCGKGITGMAALHPEINYIAIDMQLSVLSYALDKAIEADNVQMMLVDGAALEIDQVYLNFSDPWPKGRHEKRRLSFLATYEKILRPEGEI......................................................................................................................... 149
59 -11.200[R] COG4122 Predicted O-methyltransferase  ali follow..  13  41..........RMQIAPEQGQFMALLVQLLGAKKTLEVGVFTGYSSLIVALAEGKLVACDINEEFTAIAQQKAGVDHKIDLYLAPALETEAETFDFAFID-------KSNYDNYYERSLQLIRSGGVIAIDNV.................................................................................................................... 171
60 -11.200[O] KOG1661 Protein-L-isoaspartate(D-aspartate) O-methyltransferase  ali follow..  19  38........RGDYYLEGYRDNAYKEALKLQPGLSFLNLGSGTGYLSTMVGLPFGINHGIELHSDVVEYAKEKLESFCEPAFVVGNCLQIASDSHDRIYCG-AGVQKDHENYM------KILLKVGGILVPIEDQL.................................................................................................................. 195
61 -11.200[G] KOG2798 Putative trehalase  ali follow..  15  144...KAQSTLKLIARDLEREQSYKPIIDELKDIKILVPGAGLGRLTYELACLGYSCEGNEFSYFMLIASNFVLNLKGHFEIAAGDFLEVTPNAYNCVATCFF------NNVIDFIRTIYKILVPGGIWVP....................................................................................................................... 330
62 -11.000[A] KOG2651 rRNA adenine N-6-methyltransferase  ali follow..  21  151.......MNMKKSHEVQAMSELISSIADYYGKQVIDLGSGKGYLSFLSLKYGLKVYGIDSSNTNTHGAEERNRKLKK........................................................................................................................................................................... 222
63 -10.800[L] COG1041 Predicted DNA modification methylase  ali follow..  15  178...........................TKATREVLDPFMGTGGMLIEAGLIGLKVYGLDIREDMVEGAKINLEYYRDYVVKVGDATKIEEKTFEAVATD------RNELYKRSLESIHSVLEGRLAIA........................................................................................................................ 290
64 -10.700[R] KOG2730 Methylase  ali follow..  11  363IIMDREGWFS--VTPEAIAEHIADRVVRNNVSVVVDAFTGVGGNAIQFALRGAHVIAIDMDPVRLKCARENAGVENYIDFICADFFDVAATKVDAVFLS---ATGCCPNGIDIFDVSLKICPNIAYFLPRNTKVSQLV----------------------------ELATKAKSRMEIEQ-SALNSKIKTITVYYGKLAYREELSNSSKT...................................... 566
65 -10.300[J] KOG2539 Mitochondrial/chloroplast ribosome small subunit component  ali follow..  13  186.NYAEI---TRTLEEFNTIPDFQP-------ETVLDFGSGAGA-GFWAIQN-KEITMVDLSDAMMKFSMDSLRNEQSSE-FRRHLIPSLNTTYDVVLAHRVRFLILIES-FGGLLEARDFLLTQGTLV........................................................................................................................ 344
66 -10.300[DR] KOG1099 SAM-dependent methyltransferase/cell division protein FtsJ  ali follow..  17  12.......YYRKAKEEGWRARSAFKLLQIDEEKRVVDLCAAPGSWSQVLSRQLPLIVAIDLQPMAIEGVIQVQGDITNARTAEVVIRHFDGCKADLVVCDGMDEFVQSQLILAGLTIVTHILKEGGKFI........................................................................................................................ 164
67 -10.200[E] COG0421 Spermidine synthase  ali follow..  17  74........YQEMI-------AHLALNSHPNPKKVLVIGGGDGLREVVKHECVEEAILCDIDEDVIKVSKQYLPEHPKVKVHIGDGFKFYQNTFDVIITDSSDPDGPAEALFPYFQLLSDALRGGGVITTQAECMWIHL.............................................................................................................. 209
68 -10.200[M] COG0357 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division  ali follow..  9  59.......................VVAPYLQGERFIDVGTGPGLIPLSIVRPEAHFTLLDSLGKRVRFLRQVQHE-ENIEPVQSRVEEFPSPPFDGVISRAFA------SLNDMVSWCHHLPGEQGRFY........................................................................................................................ 162
69 -9.910[R] COG1092 Predicted SAM-dependent methyltransferases  ali follow..  12  224...........FYLDQRDSRFQSMKYVK--EKEVLNCFSYTGGFGLYALKGGARVINADVSQPALDTAKFNAELNKRAVFLNADVFKLQGTRFDVVVMDPPKFAESKAQLDGACMLAMQILNPGGTLLTYSCSGLMD............................................................................................................... 367
70 -9.890[R] COG4262 Predicted spermidine synthase with an N-terminal membrane domain  ali follow..  21  273.......YHEALV--------LPALESVRGARRVLVLGGGDGLAQILKYPQVEHVTLVDLDPRMTSLFSHAEALVARVTVVNADAGQWAADMFDVAIVDFPDPSNFSIGKLPFYRLLSRHVADTGLVVIQATSPYFAP.............................................................................................................. 412
71 -9.540[E] KOG1562 Spermidine synthase  ali follow..  20  69..FESTTYGNVLVLDGIVQATYQEMLAHPDPKRVLIIGGGDGLREVLKHESVEKVTMCEIDEMVIDVAKKFLPGHPKLDLFCGDGFEFHKNEFDVIITDSSDESLFGQSYYELL---RDALKEDGILSSQGECPWLDM.............................................................................................................. 229
72 -9.540[R] KOG3178 Hydroxyindole-O-methyltransferase and related SAM-dependent methyltransferases  ali follow..  20  175......KLFEYIQADERFGKVFNRAMLESSTKTLVDVGGGLGNTLGLITSKYPHLIGINFD---LAPVLANAHSYPGVNHVAGDMFI-KIPKGDAIFMKWILHDWTDEQCVAILKNCWKSLEENGKLI........................................................................................................................ 308
73 -9.300[S] KOG1045 Uncharacterized conserved protein HEN1/CORYMBOSA2  ali follow..  16  714...............KQRVEYALKHIRESSASTLVDFGCGSGSLLDSLLDYPQTIIGVDISPKGLARAAKMLHVKKSATLYDGSILEFDSRDVDIGTCLEVIEHMEEDQACEFGEKVLSLFHPKLLIV........................................................................................................................ 839
74 -9.210[J] COG0293 23S rRNA methylase  ali follow..  13  15......KWYKLAKEQGYRSRAAFKLVQLNQKKVIIDLCAAPGGWLQVASKPGSLIVGVDLAPI-IPNCHTFVEDITSDKCRSQLRGYLKTWKADVVLHDGQDAYGQAQLVLMSMKLACEFLVAGGTFV........................................................................................................................ 156
75 -9.210[AR] KOG1098 Putative SAM-dependent rRNA methyltransferase SPB1  ali follow..  13  15......KWYKLAKEQGYRSRAAFKLVQLNQKKVIIDLCAAPGGWLQVASKPGSLIVGVDLAPI-IPNCHTFVEDITSDKCRSQLRGYLKTWKADVVLHDGQDAYGQAQLVLMSMKLACEFLVAGGTFV........................................................................................................................ 156
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;