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Query: [K] COG4189 Predicted transcriptional regulator, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAPNFLLVDAEKEFDVLKAAASLIRVQILKLLHEANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRKARKGSQKICFATCDELIVSFRKPETPAASNYIAVAMPLGLYTQSSVTAPCGICSPEGIIGLLDVPDTFMDPDRMKTALLWLTSGFVEYQFPNNAKIQGRNVEEIEFSMEVSSEVPGTHSNWPSDITLSVNGKEIGVWTSPGDFGDKRGVFTPDWWKLSGSQYGMLKTWRITPQGTYVDGTRISDVTLADIDLASHRSIRLRIEVKADAKHPGGLNIFGRGFGNYDQDIVLRLRTAVLast
1 -131.000[K] COG4189 Predicted transcriptional regulator  ali  100  1MAPNFLLVDAEKEFDVLKAAASLIRVQILKLLHEANGLNVNEIAQRLALPQSTVSAGVAVLEEAGLLRTETRKARKGSQKICFATCDELIVSFRKPETPAASNYIAVAMPLGLYTQSSVTAPCGICSPEGIIGLLDVPDTFMDPDRMKTALLWLTSGFVEYQFPNNAKIQGRNVEEIEFSMEVSSEVPGTHSNWPSDITLSVNGKEIGVWTSPGDFGDKRGVFTPDWWKLSGSQYGMLKTWRITPQGTYVDGTRISDVTLADIDLASHRSIRLRIEVKADAKHPGGLNIFGRGFGNYDQDIVLRLRTAV 309
2 -38.200[S] COG4860 Uncharacterized protein conserved in archaea  ali follow..  11  2VSRIKVVNDPGELVSIFHAADSEVKRKLLLDLST-GWITLPVIEQKYG---KEGRRALLYLDKIKMIETQWITGQNGPEKAYHTYYTNVQINIMGSLSELADIIYAATLSDEQLSEYEDKIKAMMKNGEGVFLGDVSDSLGISQTLIRG---------IVKRSSI-LEIRGYKIELVS................................................................................................................................... 165
3 -23.800[K] COG1777 Predicted transcriptional regulators  ali follow..  16  3..........DDIDNFIAAIENSTRREIIRMLTQFERSYALELSRSIGLSQQAILKQLEMLERANLVTSIGFVPSS......................................................................................................................................................................................................................................... 68
4 -20.400[K] COG4190 Predicted transcriptional regulator  ali follow..  17  60.............YDDLMDTLTPRVLELIEAIRQEEPASINETARVVDRDVKNVHEELSRLAHLGIIFFEEDGQRK......................................................................................................................................................................................................................................... 122
5 -17.700[K] COG1497 Predicted transcriptional regulator  ali follow..  12  1.............MKALRKKGELTRFQILSEIAMRQYVRQKDIADKLGVTVQAVSENIKSLIAEGLVESG-------SGRSHYKITRRGAEKIKEAAMDLRRYADEVLESMSFYRSVWPAIAWEDLQEGDKVE------------------LFMEDGILYARRRRNGEAYAEVLHPAR------------------------RGEDVALSELGGTIPLQRGKVTPGISEGGSRNADLERLRELSRGHDRTGIMGTVSRAAANKLNLQVDFEFATPHAALAAAKRG-VLAVGKMSRSITEKLEEGVEYSV 256
6 -16.400[K] COG2345 Predicted transcriptional regulator  ali follow..  19  7.............GNDAHTGDGDTRRKILLILLERAPVIASDIAEQLQLSTVGVRRHLDNLVEENLAEAANPRQNPYEP...................................................................................................................................................................................................................................... 72
7 -16.000[S] COG3398 Uncharacterized protein conserved in archaea  ali follow..  8  99...........RITERADVFENSNRARIYEYIKTRPGAYLSEIIEKAGIDRGAARYHIKILKAHHKIEAYRESGKTRYFQNNSTYGEEEKKVVSALQNATNQRIISEIQNGKCNTNLALAREIGVSRAT.................................................................................................................................................................................... 216
8 -15.700[K] COG5625 Predicted transcription regulator containing HTH domain  ali follow..  16  1MKQEEMLKKLEDLLKAIGLKKNEIRI-YRLLVEKRRGMRIREIQRELGISERSVRTHVLNLYRRGLLKRELVQSGWLGYIYTPVSPLEILQKIKEHLMKSIEELERDLKNQTR.................................................................................................................................................................................................... 112
9 -15.000[K] COG0640 Predicted transcriptional regulators  ali follow..  22  1.......................................MNEITMQTQADQPKVSSNLAILSEARLVDSIQM-GREKIYRIAPEKFEDMVDWLDSIL.................................................................................................................................................................................................................... 57
10 -13.200[K] COG3355 Predicted transcriptional regulator  ali follow..  23  26.....................SKSDVEVLHILLQNGKMTTDDLSQKLNVTKASISKALNNLLDKGLIQREKAPAEKEERKG.................................................................................................................................................................................................................................... 85
11 -13.200[S] COG4519 Uncharacterized protein conserved in bacteria  ali follow..  13  1................MELSPVFARLYLALLVESLERPNVPKLIEKTGWPRRTIQDVIKAMPGIGIELNFVQDGRR......................................................................................................................................................................................................................................... 61
12 -12.700[S] COG3388 Uncharacterized protein conserved in archaea  ali follow..  14  1MKEYSIFREIINDMDTLK-----RHISVINVLLREQPIGIIKLSQETGIPEHKIRYSLRILEQENIIS................................................................................................................................................................................................................................................. 63
13 -11.900[K] COG4738 Predicted transcriptional regulator  ali follow..  12  19......GEVEYEMVELLRRLNNRPVALTLACLSKGDEISSQRIEMVSGLRQPEVSIAMRYLRENEWVDMREEKGRPVKLYKLTVQMETIIDTIEENVIAESKTILQNIERLKSLS.................................................................................................................................................................................................. 133
14 -11.900[S] COG3373 Uncharacterized protein conserved in archaea  ali follow..  23  8..............NILRSLNSELRRKVLFYLLSIYPSYLSEISRAVKSDPSNVKGCLESLIGLGLVIVEQSKNGFKYFKI.................................................................................................................................................................................................................................... 87
15 -11.700[K] COG1510 Predicted transcriptional regulators  ali follow..  11  1MKKTALDIIEHAEEHLIEKIAPSTVGRVLGIIMNRKPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVR---KDLYDVEQDYYQTFISLFAANWTKVVS........................................................................................................................................................................................................... 112
16 -11.600[K] COG4742 Predicted transcriptional regulator  ali follow..  11  2...........QSELIDVVFRSQKRRDLLLLLGE-EPRTMEDIKVLLDVSPTAILPQIKRLTDSNLVI---QKNGSYELTDMGEQVFKKARALVDVLTLVEKDNYWIEHDLGGIPQYLLDKIGEIKDCNLVKADPSQIFEPNTELLEYFASSRYLMVFSSFYRPEFLPLYSKLGRLSEVSLIFTESVEKFLYNYEKKIRRLATMDNTELCVCKDGV............................................................................................. 204
17 -11.200[K] COG1675 Transcription initiation factor IIE, alpha subunit  ali follow..  12  1MKAETTTGVEELLNELVGRAAGE-VGLILFSLGIEGEFTDDQLSLELGIEINEIRKALFALYEIGLADYVRRRDDETGWMEYYWRIN--YDKALDVLKRELEKTAKKLREKIEAETSTIYYICPNMCVK--VSYNDAMELNFTCPRCGAML-------DYLDCSKAIEKIEEEVRRIEEILESLDKNSG........................................................................................................................ 177
18 -10.700[S] COG4344 Uncharacterized protein conserved in archaea  ali follow..  22  2.........SEYEKEIDELINDYDMLRVLKHFTIAHVDYAKNITRYTEIPQMRVREYLKRLKDLGLLD................................................................................................................................................................................................................................................. 60
19 -10.600[KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon  ali follow..  16  2.....................KMKTLFLLIKLAKMGTVTMRELSRELDVSPQTVLRWLEELKEQGYIHKRESRKGT......................................................................................................................................................................................................................................... 62
20 -10.200[K] COG1846 Transcriptional regulators  ali follow..  21  41.....................TPSEIHTIDAIGTDEGLLMKELAERLGVTKGAVSQLVDRLEAKALVRRTAHPKVSRGIQVV................................................................................................................................................................................................................................... 101
21 -10.000[K] COG1654 Biotin operon repressor  ali follow..  14  5......................TVPLTLISLLADGEFHSGEQLGERLGMSRAAINKHIQTLRDWGVVFTVPGKGYSLPEPIQLLDADRIHSQL........................................................................................................................................................................................................................ 76
22 -9.000[K] COG3432 Predicted transcriptional regulator  ali follow..  13  35.......................GTMEIMFDILREPKCGITRVIYGAGINYVVAQKYLDQLVKVGALNIKTENDRK......................................................................................................................................................................................................................................... 89
FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 8 6 2   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Rychlewski L, Zhang B, Godzik A. Fold prediction by a hierarchy of sequence, threading, and modeling methods. Protein Sci. 1998 Jun;7(6):1431-40.