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Query: [R] COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAATADAQLLNYVAWPQATLHGGRGGKVIGFMMPKVSGKEPIHMIYSPAHRRQSYPHCAWDFLLYVARNIASSFATVHEHGHVVGDVNQNSFMVGRDSKVVLIDSDSFQINANGTLHLCEVGVSHFTPPELQTLPSFVGFERTANHDNFGLALLIFHVLFGGRHPYSGVPLISDAGNALETDIAHFRYAYASDNQRRGLKPPPRSIPLSMLPGDVEAMFQQAFTESGVATARPTAKAWVAALDLLRQQLKKCTVSAMHVYPGHLTDCPWCALDNQGVIYFIDLGEEVITTSGDFVLAKVWAMVMASVAPPALQLPLPDHFQPTGRPLPLGLLRREYIILIEIALSALSLLLCGLQAEPRYIILVPVLAAIWIIGSLTSKVYKAEIQQRREAFNRAKMDYDHLVSQIQQLGGLEGFIAKRAMLEKMKDEILGLPEEEKRALAALHDTARERQKQKFLEGFFIDAASIPGVGPARKAALRSFGIETAADVTRRGVKQVKGFGDHLTQAVIDWKASCERRFVFRPNEAVTPAERQAVMAKMAAKRHRLESALTVGATELQRFRLHAPARTMPLMEPLRQAAEKLAQAQADLSRCLast
1 -158.000[R] COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains  ali  100  1MAATADAQLLNYVAWPQATLHGGRGGKVIGFMMPKVSGKEPIHMIYSPAHRRQSYPHCAWDFLLYVARNIASSFATVHEHGHVVGDVNQNSFMVGRDSKVVLIDSDSFQINANGTLHLCEVGVSHFTPPELQTLPSFVGFERTANHDNFGLALLIFHVLFGGRHPYSGVPLISDAGNALETDIAHFRYAYASDNQRRGLKPPPRSIPLSMLPGDVEAMFQQAFTESGVATARPTAKAWVAALDLLRQQLKKCTVSAMHVYPGHLTDCPWCALDNQGVIYFIDLGEEVITTSGDFVLAKVWAMVMASVAPPALQLPLPDHFQPTGRPLPLGLLRREYIILIEIALSALSLLLCGLQAEPRYIILVPVLAAIWIIGSLTSKVYKAEIQQRREAFNRAKMDYDHLVSQIQQLGGLEGFIAKRAMLEKMKDEILGLPEEEKRALAALHDTARERQKQKFLEGFFIDAASIPGVGPARKAALRSFGIETAADVTRRGVKQVKGFGDHLTQAVIDWKASCERRFVFRPNEAVTPAERQAVMAKMAAKRHRLESALTVGATELQRFRLHAPARTMPLMEPLRQAAEKLAQAQADLSRC 591
2 -31.600[RTKL] COG0515 Serine/threonine protein kinase  ali follow..  17  65MAELNHPNIVAIR---------GEEDGQQFLVMEYVDGADLKRYI-------QNHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKEGVVKVTDFGIAVAFAETSLTNSMLGSVHYLSPE-----QARGSKATIQSDIYAMGIMLFEMLT-GHIPYDGDSAVTIALQHFQKP------------------LPSIIEENHNVPQALENVVIRATAKKLS-DRYGSTFEMSRDLMTALSY....................................................................................................................................................................................................................................................................................................................................................... 275
3 -26.300[D] KOG0580 Serine/threonine protein kinase  ali follow..  12  129QAHLHHPNILRLYNY--------YDRRRIYLILEYAPRGELYKELQKSCTFDE-------QRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFG-WSVHAPSLRRKTMCGTLDYLPPEMIEGRMH-----NEKVDLWCIGVLCYELLV-GNPPFESA-----SHNETYRRIVKVDLKFP-----------------ASVPTGAQDLISKLLRH--NPSERLPLAQWVRA.............................................................................................................................................................................................................................................................................................................................................................. 329
4 -24.600[T] KOG0195 Integrin-linked kinase  ali follow..  10  241LRIFSHPNILPIIG---------NSPPNLVTISQFMPRSSLFSLLHGATGVV-----VDTSQAVSFALDVARGMAFLHSLEIPTYHLNSHHVMIDDDLTAR-INMGDAKFSFQEK---GRIYQPAWMSPETLQRKQAD--RNWEACDMWSFAILIWELTT-REVPFAEWSPMECGMKIALEGLR------------------------PGTSTHMAKLISICMNE--DPGKRPKFDMVVPILEKMRR........................................................................................................................................................................................................................................................................................................................................................ 448
5 -24.500[T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)  ali follow..  13  98...LNEKRILQAIDFPVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRF-------YAAQIVLAFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFAKRVKGRTWTLC--GTPEYLAPEIILSKGY-----NKAVDWWALGVLIYEMAA-GYPPFFAD-----QPIQIYEKIVSGKVKFP-----------------SHFSNELKDLLKNLLQV--DLTKR-GSTDWIAIYQK........................................................................................................................................................................................................................................................................................................................................................... 317
6 -24.400[D] KOG0615 Serine/threonine protein kinase Chk2 and related proteins  ali follow..  15  225MKKLSHPNIVA-------IYDCITVAKYSYMVIEYVGGGEFFSKLVDSKYNQMGLGESLGKYFAF---QLIDAVLYLHSVGICHRDIKPENILCSNKAELKLTDFGMAKNSVNRMKTHC--GTPSYCAPEIVANQ---GVEYTPKVDIWSLGCVLFITFS-GYPPFSE----EYTDLKMDEQVLTGRLFF--------------HEQWHRITDETQNMIQWMLT---EPLIRPSAVEWMKC.............................................................................................................................................................................................................................................................................................................................................................. 437
7 -24.300[T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)  ali follow..  12  110VLAAPNTALQKQLLRELKINRSCTSPYIVKYAMEYCGAGSLDAIY---KRVRSQGGRTGERPLGKIAFGVLSGLSYLHDRKIIHRDIKPSNILLTSKGQVKLCDFG-VSGELVNSLAGTFTGTSYYMAPERISGGSY-----TISSDIWSLGLTLME-VALNRFPFPPEGSPPPMPIELLSYIINMPPPLLPQEPGIK------------WSKSFQHFLCVCLDK--DKTRRPGPQKMLT............................................................................................................................................................................................................................................................................................................................................................... 339
8 -24.000[T] KOG0033 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily  ali follow..  14  63CRKLQHPNI-------VRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSE-------ADASHCIQQILESIAYCHSNGIVHRDLKPENLLLAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPY-----SKPVDIWACGVILY-ILLVGYPPFWDE-----DQHRLYAQIKAGAYDY-------------PSPEWDTVTPEAKSLIDSMLTV--NPKKRITADQWIC............................................................................................................................................................................................................................................................................................................................................................... 270
9 -23.900[T] KOG0604 MAP kinase-activated protein kinase 2  ali follow..  11  135.....................SYNGVDCLLVVMENMKGGELFNRIQERGQKA-----FTEREAAGIVNEICSAVAHLHRMSIAHRDLKPENLLYASNAALKLTDFGFAKKESEPQGLKTACFTPYYCAPEVLGTEKY-----DKSCDLWSIGVIMY-ILLCGYPPFYSQH-GQPMSPGMKAKIKSGQYTF-------------PSPEWDCVSEAAKDLIRKLLRT--EPTERITIEQWISHYRRVPDT....................................................................................................................................................................................................................................................................................................................................................... 344
10 -23.800[KIT] KOG2345 Serine/threonine protein kinase/TGF-beta stimulated factor  ali follow..  14  100SSLFNHPNLLPLLDHAIISVKDGQEGA-AFLLFPVHLDGTLLDNF---TLMKAKKETFSTTDVLHIFRQLCDGLKHMHSLEYAHNDVKPGNVLLTRRKGAILMDFGSARPSRKQIRSRQEACSAPFRAPELWD---PSHADIDERTDIWSLGCTLYAIMY-GVSPFEYALGESGGSLQL--AIVNAQIKW------------PNTGPKASYPEALHQFVTWMLQP--QAAVRPRIDDIIIHVDKLIAKFTK.................................................................................................................................................................................................................................................................................................................................................... 347
11 -23.300[D] KOG0575 Polo-like serine/threonine protein kinase  ali follow..  134HRILHHKHVVQFYHY--------EDKENIYILLEYCSRRSMAHILKARKVLTE-------PEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGAARLEPLEHRRRTICGTPNYLSPEVLNKQGH-----GCESDIWALGCVMYTMLL-GRPPFETTNL-----KETYRCIREARYTMP-----------------SSLLAPAKHLIASMLSK--NPEDRPSLDD-------IRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTLLM-SGCSSELKNRMEYALNMLLQRCN............ 685
12 -23.000[T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase MKK7/JNKK2  ali follow..  12  151MRRSGNKEENKRILMDLDVVLKSHDCPYI-IAMELMGTCAE-------KLKKRMQGPIPERILGKMTVAIVKALYYLEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVE-LATGQFPYKNCKTDFEVLTKVLQE------------------EPPLLPGHMGFSGDFQSFVKDCLTK--DHRKRPKYNKLLE............................................................................................................................................................................................................................................................................................................................................................... 376
13 -22.800[T] KOG0193 Serine/threonine protein kinase RAF  ali follow..  15  397LRKTRHVNIL--------LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETK------FQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRSQQVEQPTGSVLWMAPEVIRMQD--NNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGR----------------GYASPDLSKLYKNCPKAMKRLVADCVKK--VKEERPLFPQILSSIELLQHSLPKINRSASE............................................................................................................................................................................................................................................................................................................................................. 622
14 -22.700[T] KOG0603 Ribosomal protein S6 kinase  ali follow..  11  83................VNLFYAFQTDTKLHIVMEYVRGGELFTHLCSRG-------HFDLEAARFVIAELVVAIDSLHQRKVIYRDLKLENILLDEEGHVKLTDFGLSKLPGELDRANSYCGTIEYMSPEVINRPEGG---YSDVVDWWSLGVISFELLT-GCSPFTVDG-AQNSSKDIAKRIMTKKVPF-----------------PKTMDVDARDFIGQLLEK--KLEKRLGYNGVDEIKNHKFMSSIDWDAAVKRTLKPVIVPRIGHDLDTQFFSAEFTSQPPLYSPAESPLNANTLFRGYSYVSPSVIFANDNVIGEELMAEDVNALLASSSFFAKYKL----DAGLLGKGAFSVVRRCERVVDGAQFAVKIVSQKFASQAQREARILEMVQGHIVQLHDVHSDPLHFYLVMEILTELLERIRKLERFTESERQLVSAVKYLHDKRIVHRDLKPENILFESIDSSARLR---LVDFGFYGLIAHNHLHSETPCFTLQYAAPEVLDWSLGVQVPFHARSRQESATEIMQRICRAEFSFTGDAWTNVSADAKNLITGLLTVDPKKRLSMQELTA............... 662
15 -22.500[T] KOG4236 Serine/threonine protein kinase PKC mu/PKD and related proteins  ali follow..  14  627LQNLHHPGIVNLECM--------ETPERVFVVMEKLHGDMLEMILSSEKSRLPE------RITKFMVTQILVALRNLHFKNIVHCDLKPENVLLEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGY-----NRSLDMWSVGVIIY-VSLSGTFPFNED-------EDINDQIQNAAFMY-------------PPNPWREISGEAIDLINNLLQV--KMRKRYSVDKWLQ............................................................................................................................................................................................................................................................................................................................................................... 833
16 -22.500[T] KOG1027 Serine/threonine protein kinase and endoribonuclease ERN1/IRE1, sensor of the unfolded protein response pathway  ali follow..  12  584....THPHVIRYFC--------ESDSQFRYLALELCIAS------LNDYVEQKEVQQNVTIALRDIMKQATDGLAHLHASKIVHRDMKPQNVLITMASQAVISDFGLCKRVQPGKNASGLAGTDGWIAPEVLISAST-----SYPVDIFSLGCIFYYVLTSGTHPFGKS-------LHRQANIVNGEYTLN-------------KLADLDDWSLADDLISSMLNV--EPLHRLTADA---VLNH-----------------------PFFWTSEKRLAYFSDVSDRVEKEEDNSPVVRRIET-----------------------------------------------------------------DARIVVCGGWREKICDALKEDLRKFRTYKS---------------FSVRDLLRAMRNKKHHYRELPEDVRQSLGDIPDQFLHYFTSRFLHVYKATEYC------SGEAVFKRYYSDDVRARMYPIVEEEERVRKKIKEEMAN--ARAPKPVEQRTPLKLDKRNIKKKSNP...................................................... 980
17 -22.500[G] KOG0599 Phosphorylase kinase gamma subunit  ali follow..  13  81........LRQVMGHPIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSE-------KKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGEKLTNLCGTPGYLAPETLKCNMFEGSPYSQEVDIWACGVIMF-TLLVGCPPFWHRKQ-----MVMLRNIMEGKYSF-------------TSPEWADISEDPKDLIRKCLV---DPSQRITVKEFFNQ.............................................................................................................................................................................................................................................................................................................................................................. 293
18 -21.800[T] KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily  ali follow..  15  160.......................EDEKAVNLVMELCAGGELFDRIIAKGHYTE-------RAAASVCRQIVNVVKICHFMGVLHRDLKPENFLLDEKALIKATDFGLSVFIEEGKVYRDIVGSAYYVAPEVLRRR------YGKEVDIWSAGIILY-ILLSGVPPFWAE-----TEKGIFDAILEGHIDF-------------ESQPWPSISSSAKDLVRRMLTA--DPKRRISAADWLREGGEASDK....................................................................................................................................................................................................................................................................................................................................................... 358
19 -21.600[T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase MKK3/MKK6  ali follow..  11  100IRATVNSQEQKRLLMDLDINMRTVDCFYT-ICMELMDTSLDKFY----RKVLDKNMTIPEDILGEIAVSIVRALEHLHSKSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL-NQKGYNVKSDVWSLGITMIE-MAILRFPYESWGTPFQQLKQVVEE-------------------PSPQLPADRFSPEFVDFTAQCLRK--NPAERMSYLELME............................................................................................................................................................................................................................................................................................................................................................... 326
20 -21.600[T] KOG0578 p21-activated serine/threonine protein kinase  ali follow..  12  298QMNLQQQPKKELIINEILVMRENKNPNIVNYVMEYLAGGSLTDVVTETCMDEGQ--------IAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY-----GPKVDIWSLGIMAIEMV--GEPPYLNENPLRA-----------------------ATNGTPELQNPERLSAVFRDFLNRCLEM--DVDRRGSAKELLQ............................................................................................................................................................................................................................................................................................................................................................... 515
21 -21.600[T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family  ali follow..  15  47MVKMEPDDDVSTLQKEILILKTCRHANIVAYCMEFCGAGSLQDIYQVTGSLSE-------LQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGSAQIGATLARRLSFIGTPYWMAPEVAAVALKGG--YNELCDIWSLGITAIE-LAELQPPLFDVHPLRV---------------------TKSGYQPPRLKEKGKWSAAFHNFIKVTLTKS--PKKRPSATKMLS............................................................................................................................................................................................................................................................................................................................................................... 270
22 -21.300[T] KOG0986 G protein-coupled receptor kinase  ali follow..  13  231..ALNEKQILEKVNSQVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG-----FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-----GLSPDYWGLGCLIYEMIE-GQSPFRGRKE-KVKREEVDRRVLETEEVYS-----------------HKFSEEAKSICKMLLTK--DAKQRLGCQNFKRLEAGMLD........................................................................................................................................................................................................................................................................................................................................................ 462
23 -21.300[T] KOG3653 Transforming growth factor beta/activin receptor subfamily of serine/threonine kinases  ali follow..  11  249VPLMEHDNIARFIV--GDERVTADGRMEYLLVMEYYPNGSLCKYLSLHT--------SDWVSSCRLAHSVTRGLAYLHTEAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRSEVGTIRYMAPEVLEGAVNLRDCESKQVDMYALGLIYWEIFMR-QMAFQTEVGNHPTFEDMQVLVSR---------EKQRPKFPEAWKENSLAVRSLKETIEDCW--DQDAEARLTAQCAEERMAELMMIWER.................................................................................................................................................................................................................................................................................................................................................... 510
24 -21.100[T] KOG2052 Activin A type IB receptor, serine/threonine protein kinase  ali follow..  11  310TILLRHENILGFIG---SDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNA--------LSHNDMVWICLSIANGLVHLHTEAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGNNPKVGTKRYMAPEVLDESDLECFEALRRTDIYAFGLVLWEVCRR-KVPFYDVVPMDPSFEDMRKVVCI-----------DNYRPSPNRWSSDSLMTGMSKLMKECWHQ--NPDVRLPALRIKKTIHKLASADEKIRLDFDE............................................................................................................................................................................................................................................................................................................................................. 567
25 -21.100[T] KOG0607 MAP kinase-interacting kinase and related serine/threonine protein kinases  ali follow..  14  256....DHPNI-------VQLLDWFEDETNFYLVMEKMRGGPLLQHILQRKYFTE-------EEARRVTKDISLALKFMHDRGIAHRDVKPENVLCNHVSPVKLCDLDPLSQVASEPDLASPVGSAEFMAPEVVDAYVGDSLKYDKKCDTWSLGVILYIMLA-GYAPFQGMCDDEDCQQDLFHRIQDGYYEF-------------PEEEWGMISEEAKDLVSNLLKR--DPVDRLVTVSFAN............................................................................................................................................................................................................................................................................................................................................................... 491
26 -20.700[R] KOG0589 Serine/threonine protein kinase  ali follow..  13  55ISKMRHPFIVEYK----------EKACYVCIVIGYCEGGDMAQAI-----KKSNGVHFQEEKLCKWLVQLLMGLEYLHSNHILHRDVKCSNIFLTKEQDIRLGDFGLAKILTSDDLTSSVVGTPSYMCPELLADIPY-----GSKSDIWSLGCCIYEMAYL-KPAFKAF-----DMQALINKINKTIVS-------------------AKYSGPFRGLVKSMLRK--NPEVRPSASDLLR............................................................................................................................................................................................................................................................................................................................................................... 254
27 -20.600[R] KOG0605 NDR and related serine/threonine kinases  ali follow..  11  229LTTTRSE-------WLVKLLYAFQDLQSLYLAMEFVPGGDFRTLLINTRCLKSGHARF-------YISEMFCAVNALHDLGYTHRDLKPENFLIDAKGHIKLTDFGLAA-EKEINYANSMVGSPDYMALEVLEGKKY-----DFTVDYWSLGCMLFESLV-GYTPFSGSSTNETYDNLRRWK--------------QTLRRPRQSDGRAAFSDRTWDLITRLIA---DPINRLRSFE.................................................................................................................................................................................................................................................................................................................................................................. 469
28 -20.600[D] KOG0601 Cyclin-dependent kinase WEE1  ali follow..  16  305....FHENIVGYYSW--------FENEQLYIQLELCDHSLS-------ALPKKSSLKVSEREILVIMHQIAKALHFVHEKGIAHLDVKPDNIYIK-NGVCKLGDFGCATRLDKSL--PVEEGDARYMPQEILNE----DYEHLDKVDIFSLGVTVYELIKGSPLTESR---------NQSLNIKEGKLP-----------------LLPGHSLQLQQLLKTMMDR--DPKRRPSARELLDMFDRIRG........................................................................................................................................................................................................................................................................................................................................................ 500
29 -20.600[T] KOG4257 Focal adhesion tyrosine kinase FAK, contains FERM domain  ali follow..  11  323MRQFDHPHIVKLIG-PVWIIME-TLGELRSFL-------------------QVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGK-KWMAPESINFRRF-----TSASDVWMFGVCMWEILMHGVKPFQGV-----KNNDVIGRIENGE----------RLPMPPN------CPPTLYSLMTKCWAY--DPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRSQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLIGNQHIYQPVGKPDPAAPPKKNLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPM-------VKEVGLALRTLLAT---ETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMT---------SLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRP.................. 878
30 -20.500[T] KOG4250 TANK binding protein kinase TBK1  ali follow..  72....GASNIVQYFSNHTKMAPGSVTSETISFAMEYASSSLEAEMR-----RPKNHRGLSSNALIDLVVDCSMALSALREHNIAHRDIKHMNILLRSTHLFKLCDMGCSKSLSENSSMRTLVGTPNLLHPFLAHNWKTKSAYTSEQCDLWALGCTLYFCAT-GKFPFEHERNNKSLYHKAVVALTQ---------------------------PDAIAMVLVQKGR--DPGRRTDIFEFVSTMTCLLRSFFHEPSIEYYAKVADAMR----SISKCLGYPEGTDILLLSNTSTHYLDSKQKSVDGLPDDLYLVVPQTSHVDMRKILARNIEFHEFDDMTDRKLSEIRIKKCYEGLSMLTEIDEYLALFDRVSTILSTQFSLLVQELSQFERVQTASRFAVYVDMASVPLMLFDEANPETKMISDQCIQQAKRAREELERHAKVSMDIEAAKQLSKDAEDLRLEDMDLPGICEEIESYVFY---------DKQAILSTQKYSQELVELCLKRRNNIMEQIFNSPDRINKSKLNKAM--NLAASLSQLRSNYRKLQDMISECVDLLEKPFQEMKDTVNRYLQAQGCSRNTMQK. 682
31 -20.300[T] KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases  ali follow..  14  194LKKCVHPNVVRLR------VIDDPSSTKVYLVLEYMSGGEVPWTDCDS-------PVLSISEARQYFRDVVLGLEYLHYQGIIHRDIKPANLLLNSSNCVKISDFGVSYIEDNDVELAKTVGTPAFFAPELCWTDLDRPRPKIEAIDVWALGVTLFCLLF-GRCPFNASME-----YELFDKIVNERLNI---------------PSTPDIGEEGRDLLKRLLCK--DPEQRITLVEWTLD.............................................................................................................................................................................................................................................................................................................................................................. 411
32 -20.200[T] KOG1151 Tousled-like protein kinase  ali follow..  495HKELDHPRIVKLYDY-------SLDTDSFCTVLEYCEGNDLDFYLKQHKLMSE-------KEARSIIMQIVNALKYLNEPPIIHYDLKPGNILLTACGEIKITDFGLSKIMDDDSLTSQGAGTYWYLPPECFVVGK-EPPKISNKVDVWSVGVIFYQCLY-GRKPFGHN---QSQQDILQENTILKATEVQF-------------PPKPVVTPEAKAFIRRCLA---RKRDRIDVQQYLL............................................................................................................................................................................................................................................................................................................................................................... 719
33 -20.100[T] KOG0614 cGMP-dependent protein kinase  ali follow..  13  473...FAERNIMMETSTDVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARF-------YVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGH-----DQAADYWALGIYICELML-GRPPFQAS-----DPMKTYTLILKGVDALEIPNRR--------------IGKTATALVKKLCRD--NPGER-MGFDWEGLRSR........................................................................................................................................................................................................................................................................................................................................................... 697
34 -20.100[T] KOG0690 Serine/threonine protein kinase  ali follow..  12  238..TLTENRVLQRCKHPTELKYSFQTNDRLCFVMEFAIGGDLYYHL--NREVQMNKEGFSEPRARFYGSEIVLALGYLHANSIVYRDLKLENLLLDKDGHIKIADFGLCKEESFGDKTSTFCGTPEYLAPEVLDDHDY-----GRCVDWWGVGVVMYEMMC-GRLPFYSK-----DHNKLFELIMAGDLRFP-----------------SKLSQEARTLLTGLLVK--DPTQRLGGGDWEATYRK........................................................................................................................................................................................................................................................................................................................................................... 466
35 -19.400[T] KOG0194 Protein tyrosine kinase  ali follow..  12  221MTLLEHKNIVALYG-PIMLVIE-PGGDLRKYL--------------------QRTPNVPSKQIIKFAMEIASGMKHLSSKNVIHRDLAARNCLITKELNVKISDFGLSVNESETKMKSLKKAPIRWLSPETFSKGLF-----NEKTDVWSYGVLLTELMTCAHDPLWPK-----NLKQVQKWIKESE----------HPHKIE-----DGDPSELKEIVDACCAK--IPSVRINFREVKNRLAMLQQK....................................................................................................................................................................................................................................................................................................................................................... 428
36 -19.400[T] KOG1187 Serine/threonine protein kinase  ali follow..  14  129LGVVEHPNLVKLIGY---CAEDDERGIQRLLVYEYVQNRSVQDHLSNRFIV----TPLPWSTRLKIAQDTARGLAYLHEFQIIFRDFKSSNILLDENWNAKLSDFGLARMSDGITHVSTVVGTIGYAAPEYIQTGHL-----TAKSDVWSYGIFLYELIT-------GRRPFDRNRPRNEQNILEWIRPHLSDIKKFKMIIDP-RLEGNYYLKSALKLAAVANR-MVKAKARPTMSQVSEMLERIVE........................................................................................................................................................................................................................................................................................................................................................ 361
37 -19.200[T] KOG0197 Tyrosine kinases  ali follow..  16  288MKALQHERLVRLYA-PIYIVTE-ARGCLLDFL------------------KTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPKWTAPEAIHFGVF-----TIKADVWSFGVLLMEVVTYGRVPYPGM-----SNPEVIRNLERGY----------RMPRPDT------CPPELRGVIAECWRS--RPEERPTFEFLQSVLEDFYTA....................................................................................................................................................................................................................................................................................................................................................... 496
38 -19.100[T] KOG1345 Serine/threonine kinase  ali follow..  13  75LHLGVHRHIVTTY----DVAFETA--GFYVFTQEYAPLGDLTSNVTDSGVGEVY--------SKRVAKQLASAIDYMHSKDIVHRDIKLDNVLIYRSDRIKLCDFG---SFPTGSTVERRNEWLPYSPPEVLEIKPEGSYKADPSHDVWQFGIVIFVCLT-GCLPWQKAASDDPRQGGLMMMPLRRTPRL------------------KLLTSNAQRMFKRFFA---ISNRPKSLADVTKFLDD........................................................................................................................................................................................................................................................................................................................................................... 291
39 -18.900[T] KOG0592 3-phosphoinositide-dependent protein kinase (PDK1)  ali follow..  10  187................FKLFFTFQDEASLYFLLEYAPHGDFLGLI-------KKYGSLNETCARYYASQIIDAVDSLHNIGIIHRDIKPENILLDKNMKVKLTDFGTAKILPEYAKSKSFVGTAEYVSPELLNDNYT-----DSRCDIWAFGCILYQMLA-GKPPFKAA-----NEYLTFQKVMKIQYAFT-----------------AGFPQIVKDLVKKLLVR--DPNDRLTIKQFEDGIQPYKINAEAMKPLQKVSESDTTVKMA--AATSQEHSVISMTAATAAFNKDYTSQPKLGSKSSTSVRSASNNTDREVIQKKVSKNRASVSSPSISTTSRGKDNRSRSSDAFWSRYLQNMDERVLLMKEVALSTRNLEDSPVGLENVALDYKNPLDIEPPTDSAGKFYKKMFLITNLGRALVFVKRRSLSMWEEQEFELQFELELNDVEKIRFISDQVLEIDGSRTIFIGCKERAVLMKLWKLIHNGMTAKPKVVSPKSDHKMFDKFILQKRQNTKKKNQAPPVPQSNRLINGLPDRCILKTPEEGALHTKRPTSLQTRSSSNYSKLLARSTQMRKNMTRTDE........ 765
40 -18.900[R] KOG0597 Serine-threonine protein kinase FUSED  ali follow..  11  55QARLKHPHVIEMI----ESFESKTD---LFVVTEFALM-DLHRYLSYNGAMGE-------EPARRVTGHLVSALYYLHSNRILHRDLKPQNVLLDKNMHAKLCDFGARNMTLGTHVLTSIKGTPLYMAPELLAEQPY-----DHHADMWSLGCIAYESMA-GQPPFCASSI-----LHLVKMIKHEDVKWP-----------------STLTSECRSFLQGLLEK--DPGLRISWTQFVEG.............................................................................................................................................................................................................................................................................................................................................................. 256
41 -18.800[T] KOG0696 Serine/threonine protein kinase  ali follow..  15  401...............PTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-------FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENWDGVTTKTFCGTPDYIAPEIIAYQPY-----GKSVDWWAFGVLLYEMLA-GQAPFEGE-----DEDELFQSIMEHNVAYP-----------------KSMSKEAVAICKGLMTK--HPGKRLGCGDWEKLERK........................................................................................................................................................................................................................................................................................................................................................... 611
42 -18.800[T] KOG1024 Receptor-like protein tyrosine kinase RYK/derailed  ali follow..  13  392LYEASHPNVLSVLG-----ISIEDYATPFVLYAATGSVRNLKSFLQDPSYAR----SVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGE-KWLSLEALQKSHY-----NEGSDVWSFGVLMWEMCTLGKLPYAEI-----DPYEMEHYLKDGY----------RLAQPFN------CPDELFTIMAYCWAS--MPAERPSFSQLQICLSEFHTQITR.................................................................................................................................................................................................................................................................................................................................................... 608
43 -18.600[TDK] KOG0668 Casein kinase II, alpha subunit  ali follow..  13  67VVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVLVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELL----VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQ-LKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLR---DHQQRLTAKE.................................................................................................................................................................................................................................................................................................................................................................. 318
44 -18.600[T] KOG0583 Serine/threonine protein kinase  ali follow..  14  86LKLLRHPHIIKLY----DVITTPTD---IVMVIEYAGG-ELFDYIVEKKRMTE-------DEGRRFFQQIICAIEYCHRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAG----PEVDVWSCGIVLYVMLV-GRLPFDDEFI-----PNLFKKVNSCVYVMP-----------------DFLSPGAQSLIRRMIV---DPMQRITIQEWFNV.............................................................................................................................................................................................................................................................................................................................................................. 287
45 -18.300[R] KOG0610 Putative serine/threonine protein kinase  ali follow..  593LKMLDHP-------FLPTLYAHFTSDNLSCLVMECCPGGDLHVLRQKQPGRW-----FPEPAARFYVAEVLLALEYLHMLGVIYRDLKPENILVRDDGHIMVTDFDQLVAEPTDARSNSFVGTHEYLAPEIIKGEGH-----GAAVDWWTFGIFLYELLY-GKTPFKGA-----TNEETIANVVLQSLKFPDNPN---------------VSFQAKDLIRGLLVK--EPENRLGTEKGAAEIKR........................................................................................................................................................................................................................................................................................................................................................... 874
46 -18.300[T] KOG0694 Serine/threonine protein kinase  ali follow..  17  467...............PTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRF-------YAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGLNGVTTTTFCGTPDYIAPEILQELEY-----GPSVDWWALGVLMYEMMA-GQPPFEAD-----NEDDLFESILHDDVLYP-----------------VWLSKEAVSILKAFMTK--NPHKRLGCVASQNGEDAIKQH....................................................................................................................................................................................................................................................................................................................................................... 665
47 -18.300[T] KOG1094 Discoidin domain receptor DDR1  ali follow..  15  629MSRLKDPNIIHLLS-PLCMITE-ENGDLNQFLSRHEP----------PNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVRWMSWESILLGKF-----TTASDVWAFGVTLWETFFCQEQPYSQLS---------DEQVIENTGEFFRDQGRQTYLPQP-----AICPDSVYKLMLSCWRR--DTKNRPSFQEIHLLLLQQGDE....................................................................................................................................................................................................................................................................................................................................................... 855
48 -18.200[D] KOG0591 NIMA (never in mitosis)-related G2-specific serine/threonine protein kinase  ali follow..  14  55LRNLKHPNIVQYC---------NRSAQVINLYMEYCGHGDLANLIQRYKEEKKRFTE---QEVLKFFTQLLLALYRCHKQSVLHRDIKPANIFLDENNSVKLGDFGLSKLDNTRVFTQSYVGTPYYMSPEIIRSSPY-----SAKSDVWALGCVIFEICML-THPFEGR-----SYLELQRNICQGNLS-------------------HHYSDDVFLLIRHCLEV--NSDLRPTTYQLLRSLSDIRSKLES.................................................................................................................................................................................................................................................................................................................................................... 290
49 -18.200[RT] KOG0598 Ribosomal protein S6 kinase and related proteins  ali follow..  13  363...............PVGLKFSFQTASDLYLITDYMSGGELFWHLQHEGRFPEQRAKF-------YIAELVLALEHLHKHDIIYRDLKPENILLDADGHIALCDFGLSKANSANATTNTFCGTTEYLAPEVL----LEDKGYTKQVDFWSLGVLVFEMCC-GWSPFYAP-----DVQQMYRNIAFGKVRF----------------PKGVLSSEGRSFVRGLLNR--NPNHRLGAVNWDLLSKK........................................................................................................................................................................................................................................................................................................................................................... 574
50 -18.200[G] KOG0658 Glycogen synthase kinase-3  ali follow..  14  128MQMLDHPNAVAL----KHSFFSRTDNEELNLVLEFVP--ETVNRVARSYSRTNQ--LMPLIYVKLYTYQICRALAYIHNSGLCHRDIKPQNLLVNPHHQLKICDFGSAKVLVKGEPNVSYICSRYYRAPELI----FGASEYTTAIDIWSTGCVMAELLL-GQPLFPGESGVDQ-GTPTREEIKCMNPNYTEFKFPQIKPHPWHKVFQKRLPPEAVDLLCRFFQ---SPNLRCTALE.................................................................................................................................................................................................................................................................................................................................................................. 360
51 -18.100[T] KOG0574 STE20-like serine/threonine kinase MST  ali follow..  12  91IKKVPVDTDLQEIIKEISIMQQCKSKYVVKYVMEYCGAGSISDIMRARRKPLSE------QEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGY-----DTKADIWSLGITAIE-MAEGRPPYSDIHPMRA-----------------------PTKPPPTFKKPEEWSSEFNDFIRSCLIK--KPEERKTALRLCE............................................................................................................................................................................................................................................................................................................................................................... 310
52 -17.900[T] KOG0665 Jun-N-terminal kinase (JNK)  ali follow..  10  77MKCVNHKNIIGLVFTPQKSLEEFQD---VYIVMELMD--ANLCQVIQM--------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY-----KENVDLWSVGCIMGEMVC-HKILFPGRDYIDTPCPEFMKKLQPTVRTYVENRPKYAGYSPADSEHNKLKASQARDLLSKMLV---DASKRISVDE.................................................................................................................................................................................................................................................................................................................................................................. 314
53 -17.900[OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy  ali follow..  11  61LSTIDHPNIIRFY----EAI---ETGDRIFLVLEYCSGGDLAGYINRHGKVPE-------AVAKHFMRQLALGLQVLQEKHFIHRDLKPQNLLLSSKEVLKIGDFGFARSLTPESMAETFCGSPLYMAPEIIRNQKY-----DAKADLWSAGAILFQLVT-GKPPFDGNNHIQ-----FHNIVRDTELKFPEDTRN-------------EIHPDCVDLCRSLLRR--NPIERLTFREFLRE.............................................................................................................................................................................................................................................................................................................................................................. 270
54 -17.800[T] KOG4721 Serine/threonine protein kinase, contains leucine zipper domain  ali follow..  13  208LRKLKHPNIIAFK----GVCTQAPC---YCIIMEYCAHGQLYEVLRAGR-------KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV-----SEKVDIWSFGVVLWELLT-GEIPYKD--------------VDSSAIIWGVGSNSLHLPVP------STCPDGFKILMKQTWQS--KPRNRPSFRQTLMHLDIASADVLATPQETYFK---------------------------------------------------------------------------------------------------------------------SQAEWREEVKKHFEKIKSEGTCIHRLDEELRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKRE......................................................................................................................................... 504
55 -17.600[D] KOG0590 Checkpoint kinase and related serine/threonine protein kinases  ali follow..  10  500..KKPAPNILNVF----DILEDSSS---FIEVMEFCPAGDLYGMLVGKSKLKGRLHPLEADCFMK---QLLHGVKFMHDHGIAHCDLKPENILFYPHGLLKICDFGTSSVERRVHAQKGIIGSEPYVAPEEFVDGEYYD---PRLIDCWSCGVVYITMIL-GHYLWKV--------ASREKDMSYDEFYKEMQRKNQFRVFEELKHVNSELATNRKIALYRIFQ---EPRKRISVGKWMKSTN--------C................................................................................................................................................................................................................................................................................................................................................... 728
56 -17.400[T] KOG0201 Serine/threonine protein kinase  ali follow..  14  60LSELKQSDVENIIKYHGSYLVGTN----LWIIMDYCHGGSVRTLM--------EAGPISEPCISLILRETLQALKFIHHAGIIHRDIKAANILVSMSGNVKLCDFGAAELNINRRKRITFIGTPYWMAPEVIR----DGQEYNVMADIWSLGITAYE-IATGSPPHAKEDPFRAVYLIAHTA-----------------------------PPRLNGNFSALLKE-DVPQRRLDSSELLK............................................................................................................................................................................................................................................................................................................................................................... 260
57 -17.400[T] KOG0582 Ste20-like serine/threonine protein kinase  ali follow..  17  66MSLINHPNVLQAHC---SFTTGHQ----LWVVMPYMAGGSCLHII-----KSSYPDGFEEPVIATLLRETLKALVYLHAHGHIHRDVKAGNILLDSNGAVKLADFGSACMFDTGDRQRTFVGTPCWMAPEVMQQLH-----YDFKADVWSFGITALE-LAHGHAPFSKYPPMKVLLMTLQNA-----------------PPGLDYERDKRFSKAFKEMVGTCLVK--DPKKRPTSEKLLK............................................................................................................................................................................................................................................................................................................................................................... 273
58 -17.100[T] KOG0661 MAPK related serine/threonine protein kinase  ali follow..  10  54LKKLNHANVIKL----KEVIRENDH---LYFIFEYMK--ENLYQLMKDRNK-----LFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVL----LRSSVYSSPIDVWAVGSIMAELYML--RPFPGTSEVDEGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLN---DPKKRPTASQ---ALKH........................................................................................................................................................................................................................................................................................................................................................... 281
59 -16.900[R] KOG0593 Predicted protein kinase KKIAMRE  ali follow..  10  55LKQLKHPNLVNL----IEVFRRKRK---MHLVFEYCDHTLL-------NELERNPNGMDSDSIVGRLRSVADRSRLAPKNQCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDT----QYGSSVDIWAIGCVFAELLTG--QPWPGKSDVDGKLIPRHQSIFKSNGFFHGISIPEPEDMETLEEKFSDVHPVALNFMKGCLK---NPDDRLTCSQ.................................................................................................................................................................................................................................................................................................................................................................. 285
60 -16.900[R] KOG0586 Serine/threonine protein kinase  ali follow..  15  107MKILNHPNIVKLF----EVI---ETEKTLYLIMEYASGGEVFDYLVAHGKMKEKEARSKFRQGCQMFTFIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG----PEVDVWSLGVILY-TLVSGSLPFDGQNL-----KELRERVLRGKYRIPF-----------------YMSTDCENLLKRFLV---NPIKRGTLEQWINA.............................................................................................................................................................................................................................................................................................................................................................. 332
61 -16.900[UT] KOG0662 Cyclin-dependent kinase CDK5  ali follow..  37.LDEDDEGVPSSALREICLLKELKHKNIV--LIDVLHSDKKLTLVFEKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARFGIPVKCYSAEVVTLWYRPPDVLFGAK----LYTTSIDMWSAGCILAELADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHPSFPAITSWSQLVPRLNSKGRDLLQKLLI---RPNQRISAEA.................................................................................................................................................................................................................................................................................................................................................................. 279
62 -16.900[T] KOG0198 MEKK and related serine/threonine protein kinases  ali follow..  14  339..GIQAQECIQQLEGEIALLSQLQHQNIVRYRLELVTQGSVQKLYER---------QLSYTVVSLYTRQILAGLNYLHDKGFVHRDIKCANMLVDANGTVKLADFG-LAEASKFNDIMSCKGTLFWMAPEVINRKDSDG--NGSPADIWSLGCTVLEMCT-GQIPYS--------------DLKPIQAAFKIGRGTLPDVP-------DTLSLDARHFILTCLKV--NPEERPTAAELLH............................................................................................................................................................................................................................................................................................................................................................... 553
63 -16.800[R] KOG3087 Serine/threonine protein kinase  ali follow..  11  104..............................IWLEFLGEDLPGGHGFSNNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGTPHLIDFGLGSVSNLVED----KGVDLYVLERAILSTHS-----KHAEKYNAWIMEGFEEVYREQGAKGAKKLKEV--KRFEEVRLRGRK................................................................................................................................................................................................................................................................................................................................................................................................................... 256
64 -16.700[T] KOG0192 Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs  ali follow..  11  698MLRLRHPNVVLFM----GAVTRPPN---FSILTEFLPRGSLYRLLHRPNH------QLDEKRRMRMALDVAKGMNYLHTSHVVHRDLKSPNLLVDKNWVVKVCDFGLSRMKHHTYLSSKSTGTPEWMAPEVLRNEPA-----NEKCDVYSFGVILWELAT-SRVPWKGLNPMQVVGAVGFQNRR------------------------DDIDLTVAQIIRECWQT.............................................................................................................................................................................................................................................................................................................................................................................. 886
65 -16.500[T] COG3642 Mn2+-dependent serine/threonine protein kinase  ali follow..  13  55..............................LKMQFIEGVPIKYLITP-----------------ELSEKVGELVGRLHSSGIVHGDLTTSNLLLAGER-LYLIDFGLAYFDKSLEARGVHVLFQTFESTH-----RGHETLVKAFEKGYGSTFIDSKDVL............................................................................................................................................................................................................................................................................................................................................................................................................................................... 163
66 -16.400[T] KOG1989 ARK protein kinase family  ali follow..  13  101....GHKNIVEFVD--SYTNCLGNGIWECMLLTEYHQK----NVLQLMNERISQNQYLTNDEILSIFTDLCEAVSFIHNRPIIHRDLKVENVLISSHKHYVLCDFGSATTQILSVEKYERNTTMCYRSPEMID---YSGLEIGLKSDIWALGVLLYRLCF-FCVPFEESPL----------AIQSVNYQFPSVPN---------------IPDEIKVLIYMLLDI--DVNRRPSIYQTSVLAFEANH........................................................................................................................................................................................................................................................................................................................................................ 320
67 -16.200[T] KOG0660 Mitogen-activated protein kinase  ali follow..  92LLRFRHENVIGI----RDILRASTLEAMVYIVQDLME--TDLYKLLKSQ-------QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPTGFLTEYVATRWYRAPEIM----LNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLT---NPNKRITVEE.................................................................................................................................................................................................................................................................................................................................................................. 323
68 -16.100[R] KOG0611 Predicted serine/threonine protein kinase  ali follow..  16  127MSALNHPNIIQIY----EVF---ENKDKIILVMEYSSGGELYDYVSRCGSLPE-------AEARRIFRQITSAVLYCHKHRVAHRDLKLENILLDQNNNAKIADFGLSNYFADKNLLTTFCGSPLYASPEIINGTPYKG----PEVDCWSLGILLY-TLVYGSMPFDGRDF-----NRMVRQIKRGAY----------------------EPSTASMLIRNMLR---NPERRATIFDWLNL.............................................................................................................................................................................................................................................................................................................................................................. 328
69 -15.900[TU] KOG1026 Nerve growth factor receptor TRKA and related tyrosine kinases  ali follow..  16  592LTNLQHEHIVKFY--PLIMVFE-KHGDLNKFLRAHGPDAVLMAEGNPPT-------ELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFDYYRVGGHTML--------RWMPPE-----SIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQL-----SNNEVIECITQGR----------VLQRPRT------CPQEVYELMLGCWQR--EPHMRKNIKGIHTLLQNLAKA....................................................................................................................................................................................................................................................................................................................................................... 813
70 -15.900[DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, kinase subunit CDK7  ali follow..  11  64LKELNHPHIVEL----IDAFPHDGS---LHLVFEYMQ--TDLEAVIRDRNI-----FLSPGDIKSYMLMTLKGLAYCHKKWVLHRDMKPNNLLIGENGLLKLADFGLARFGSPNRRFTHQVFATWYRAPELLFGSR----QYGAGVDVWAAGCIFAELLL--RRPLPGSTEIDQLGKTPVPSQWSDMIYLPDYMEFSYTPAPPLRTIFPMASDDALDLLAKMFI---DPRQRITIQQ.................................................................................................................................................................................................................................................................................................................................................................. 286
71 -15.600[D] KOG0588 Serine/threonine protein kinase  ali follow..  16  69MKLIDHPHVLGLS----DVY---ENKKYLYLILEHVSGGELFDYLVKKGRLTP-------KEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDG----RKADVWSCGVILYALLV-GALPFDDDNL-----RQLLEKVKRGVFHIP-----------------HFVPPDCQSLLRGMIE---NPDRRLTLAEWVTA.............................................................................................................................................................................................................................................................................................................................................................. 271
72 -15.300[T] KOG4717 Serine/threonine protein kinase  ali follow..  12  67MKLVQHPNIVRLY----EVI---DTQTKLYLILELGDEGDMFDYIMKHEEGLNE------DLPKKYFAQIVHAISYCHKLHVVHRDLKPENVVFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA----PAVDIWSLGVILF-MLVCGQPPFQEAND-----SETLTMIMDCKYTVP-----------------SHVSKECKDLITRMLQ---DPKRRASLEEWLQG.............................................................................................................................................................................................................................................................................................................................................................. 271
73 -15.300[R] KOG0594 Protein kinase PCTAIRE and related kinases  ali follow..  55LKELKHPNIVRL----LDVVHNERK---LYLVFEFLS--QDLKKYMDSTPGSE----LPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARFGVPLRTYTHEVVTLWYRAPEILLGSK----FYTTAVDIWSIGCIFAEMVT-RKALFPGDSEIDQLFRIFRMLGTPSEDTWPYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQ---DPSQRITAKT.................................................................................................................................................................................................................................................................................................................................................................. 279
74 -15.200[K] KOG0666 Cyclin C-dependent kinase CDK8  ali follow..  10  70LRELKHPNVISL----QKVFLSHADRKVW-LLFDYAEDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGRVKIADMGFARLFNSPADLDPVVVTFWYRAPELLLGAR----HYTKAIDIWAIGCIFAELLT--SEPFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKCSLIKYMEKHKVKPDSKAFHLLQKLLT---DPIKRITSEQ.................................................................................................................................................................................................................................................................................................................................................................. 328
75 -14.900[L] KOG1167 Serine/threonine protein kinase of the CDC7 subfamily involved in DNA synthesis, repair and recombination  ali follow..  16  89LKHLIPTSHPIRIAAELQCLTV-RKNDHVVIAMPYLEHESFLDIL----------NSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRLKKYALVDFGLAQ-LSRRQQVAPRAGTPGFRAPEVL----TKCPNQTTAIDMWSAGVIFLSLLS-GRYPFYKASDDLTALAQIMT.......................................................................................................................................................................................................................................................................................................................................................................................................................... 429

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Rychlewski L, Zhang B, Godzik A. Fold predictions for bacterial genomes. J Struct Biol. 2001 May-Jun;134(2-3):219-31. Review.