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Query: [S] COG4259 Uncharacterized protein conserved in bacteria, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MMNPKTLSRLSLCAAVLALTACGGNGQKSLYYYGGYPDTVYEGLKNDDTSLGKQTEKMEKYFVEAGNKKMNAAPGAHAHLGLLLSRSGDKEGAFRQFEEEKRLFPESGVFMDFLMKTGKGGKRLast
1 -74.800[S] COG4259 Uncharacterized protein conserved in bacteria  ali  100  1MMNPKTLSRLSLCAAVLALTACGGNGQKSLYYYGGYPDTVYEGLKNDDTSLGKQTEKMEKYFVEAGNKKMNAAPGAHAHLGLLLSRSGDKEGAFRQFEEEKRLFPESGVFMDFLMKTGKGGKR 123
2 -20.600[S] COG3014 Uncharacterized protein conserved in bacteria  ali follow..  12  1...MKIFVLLMSVILGISLTGCIGYRMNTLYYEESPKKAYEYSKQFTKKKKNALLWDLQN--------------------GLSALYARDYKTSLGVLDQAEQRFDKTQSAFTRGAGYVGA... 102
3 -18.900[NU] COG3063 Tfp pilus assembly protein PilF  ali follow..  16  1.MPFKPSKRI-SLLLVLALGACSTSYRPSRAEKANQVSNIKTQL--RGQDYRQATASIEDALK------DPKNELAWLVRAEIYQYLKVNDKAQESFRQALSIKPDSAEINNNYGWFLCGR.. 117
4 -18.700[R] COG4785 Lipoprotein NlpI, contains TPR repeats  ali follow..  13  1...MKPFLRWCFVATALTLAGCSNTSWRKSEVLA-----------QPTLQQEVILARMEQILASRALTD-DERAQLLYERGVLYDSLGLRALARNDFSQALAIRPDMPEVFNYLGIYLTQAGN 111
5 -17.300[R] COG4105 DNA uptake lipoprotein  ali follow..  14  12.PQRSVLLALSLVVPSLFLSACMSSEKDIDLS---YNQGLANLNAGRLDEASKKFDAVDRQHPYSEWARK-----SMVMGAFADYRKGSYDEAISSAKRYLALYPSTD............... 122
6 -16.300[U] COG5010 Flp pilus assembly protein TadD, contains TPR repeats  ali follow..  16  18.........VAVAMVALSLSACAGQQGRKELTTGSIPKLTRPVQSMNATELAAAAERIGQAYER-----NPKDREAGLNYANLLRMTGRNEQALAVMQQVAIYHPADREVLGAYGKAQAAAGQ 126
7 -16.300[U] KOG3081 Vesicle coat complex COPI, epsilon subunit  ali follow..  7  181..........................................NLAVGGSKIQEAYLIFEDFSEK-----YPMTCLILNGKAVCCMQMGNFDEAETLLLEALNKDAKDPETLANLVVCSLHVGK 256
8 -15.800[M] KOG3364 Membrane protein involved in organellar division  ali follow..  8  43...................................FNYAWGLIKSTDVNDERLGVKILTDIYKEAESRRRE----CLYYLTIGCYKLGEYSMAKRYVDTLFEHERNNKQVGALKSMVEDKIQK 126
9 -15.700[S] KOG4555 TPR repeat-containing protein  ali follow..  15  100................................................KRDEEALDDLNKALELANDQQTRTKCHAHCQRGVLYRKLDNLEAARADFEAAAQLGSKFAREQLVEINPYAA... 171
10 -15.400[R] KOG0553 TPR repeat-containing protein  ali follow..  13  100............................EQMKVENFEAAVHFYGKAIEGNYAGAVQDCERAIC------DPAYSKAYGRMGLALSSLNKHVEAVAYYKKALELDPDNETYKSNLKIAELKLRE 208
11 -15.300[DO] KOG1173 Anaphase-promoting complex (APC), Cdc16 subunit  ali follow..  11  588................................................HKYEEALYNFQYALL------KPQSPTTYTSIGFIHALLGNLDPAIEAFHKSLALNRDCIVTSTILKSCIEDLMD 657
12 -15.000[O] KOG0548 Molecular co-chaperone STI1  ali follow..  8  1..................MAEEAKAKGNAAFSSGDFTTAINHFTEAIAHQYAEALSDAKETIK------KPYWPKGYSRLGAAHLGLNQFELAVTAYKKGLDVDPTNEALKSGLADAEASVAR 119
13 -14.900[DO] KOG1174 Anaphase-promoting complex (APC), subunit 7  ali follow..  14  456................................................QKYEDGIALLRNALANQSDCV------LHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEKEESP 524
14 -14.700[R] KOG1128 Uncharacterized conserved protein, contains TPR repeats  ali follow..  7  481................................................KKFEEAYKHLRRSLE------QPIQLGTWFNAGYCAWKLENFKESTQCYHRCVSLQPDHFEAWNNLSAAYIRHGQ 550
15 -14.500[S] KOG3060 Uncharacterized conserved protein  ali follow..  14  133................................................GRRLEAIKELNEYLKK-----FMSDQEAWHELCNMYLAEGEFGKAAFCMEEVLLHNPHSHLIHQRLAEIRYTMGG 202
16 -14.500[S] KOG4340 Uncharacterized conserved protein  ali follow..  15  49..........................AQALYKACLYPEATRVAFL-SEGDLPGSRSLVEQLLSGGEESGGDNETDGQVNLGCLLYKEGQYEAACSKFSATLQASGYQPDLSYNLALAYYSSRQ 166
17 -14.500[S] COG4700 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats  ali follow..  9  17AYRTGQERYWIFIIFCFPVIGCV------AYFVIVMLPETGRHGHTLLMRLQDKLNPERHLRKLTEELAIAETNQNHYALANELARLGRYHEAVPHYQQALSGIFHEAAMMLSLAQAQFAIQE 136
18 -14.400[U] KOG0547 Translocase of outer mitochondrial membrane complex, subunit TOM70/TOM72  ali follow..  7  141................................................KNFNEAIKYYQYAIE------DPNEPVFYSNISACYISTGDLEKVIEFTTKALEIKPDHSKALLRRASANESLGN 210
19 -14.400[O] COG4235 Cytochrome c biogenesis factor  ali follow..  11  71..............................................NEEEMSRLALGMRTQLQK-----NPGDIEGWIMLGRVGMALGNASIATDAYATAYRLDPKNSDAALGYAEALTRSSD 142
20 -14.300[R] KOG1129 TPR repeat-containing protein  ali follow..  12  354................................................GDLVSAARSFRIALS------DPDHSESLVNLGILKHREGKIDEARSLYSSATSKNPYMFEGNYNLGLVSFTQGK 423
21 -14.100[S] KOG2796 Uncharacterized conserved protein  ali follow..  10  239.................................................DIKTAEKYFQDVEKTQKLDGLQGKIMVLMNSAFLHLGQNNFAEAHRFFTEILRMDPRNAVANNNAAVCLLYLGK 313
22 -13.800[B] KOG1156 N-terminal acetyltransferase  ali follow..  9  19............................RCYEHKQYRNGLKFCKQNCLGKKEEAYELVRRGLRNDLKSHV-----CWHVYGLLQRSDKKYDEAIKCYRNALKWDKDNLQILRDLSLLQIQMRD 129
23 -13.800[D] KOG1126 DNA-binding cell division cycle control protein  ali follow..  12  445.................................REHSQALKCINRAIQEEYEKSKTSFRKAIR------NVRHYNAWYGLGMVYLKTGRNDQADFHFQRAAEINPNNSVLITCIGMIYERCKD 548
24 -13.800[R] COG4976 Predicted methyltransferase (contains TPR repeat)  ali follow..  16  1.............................................................MTFNQLSSGDLIADRRADYAKMLAEAGDAPGAAELMAQALELAPDWAAGWFRLADYEEKSGR 62
25 -13.700[R] COG4455 Protein of avirulence locus involved in temperature-dependent protein secretion  ali follow..  16  16..............................................QEYSIAEGIQMAEQQVRE-----NPAKALCRHSLFQLLCVAGDWSRALHQLQLCARMEANYTQEARLYRELVRCEM. 86
26 -13.600[R] KOG1125 TPR repeat-containing protein  ali follow..  21  444...........................................MSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDR 523
27 -13.600[S] KOG4648 Uncharacterized conserved protein, contains LRR repeats  ali follow..  14  113................................................ESLSQESESEEDGIH------DSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKK 182
28 -13.200[DO] KOG1155 Anaphase-promoting complex (APC), Cdc23 subunit  ali follow..  11  387................................................KNTPAAIDAYRRAVD------NPTDYRAWYGLGQAYEMMGMPFYALHYFRKSIFFLPNDSRLWIAMAKCYQTEQ. 455
29 -12.800[T] KOG4162 Predicted calmodulin-binding protein  ali follow..  12  761................................................EQWFDAKQCFLNAVA------NPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGD 830
30 -12.700[R] COG5633 Predicted periplasmic lipoprotein  ali follow..  8  1...MRKGCFGLVSLALLLLVGCRSHPEIPVNDEQS-SSLLAAGISAEKPVLSTSDIQPSASSTLYNERQEPVTVHYRFYW---YDARGLEMHPLERPRS-VTIPAHSAVTLYGSANFLGAHK. 118
31 -12.500[OT] KOG1308 Hsp70-interacting protein Hip/Transient component of progesterone receptor complexes and an Hsp70-binding protein  ali follow..  11  126..............................................NDGELQKAIDLFTDAIK------NPRLAILYAKRASVFVKLQKPNAAIQDCDRAIEINPDSAQPYKWRGKAHRLLGH 197
32 -12.500[U] KOG4056 Translocase of outer mitochondrial membrane complex, subunit TOM20  ali follow..  11  1.MVGRNSAIAAGVCGALFIGYCIYFDRKRRSD--NFKNRLRERRKKQKLAKERAGLSKLPDLKDAEAVQK------EIQLGEELLAQGEYEKGVDHLTNAIAVCGQPQQLLQVLQQTLPPP.. 117
33 -12.200[R] KOG1124 FOG: TPR repeat  ali follow..  15  154...........................................................AAAARAQERPLAVNLDLSLYKAKVLARNFRYKDAEKILEKCIAYWPEDGRPYVALGKILSKQSK 217
34 -12.100[R] COG3218 ABC-type uncharacterized transport system, auxiliary component  ali follow..  9  5INGQKRRALFLAPLFAALMAGCAGAPNNDTFDLSVSSAAVTQGPSLKSRQLLIADPTALKALDSEN----------------IVVRLSGSE--VQYLGNSQWSDRLPRMVQSKLVEAFEDTG. 108
35 -12.000[R] COG5645 Predicted periplasmic lipoprotein  ali follow..  20  25IMIRNVLLAFMICSGMALLGGCSSVMSHTGGKEGTYPGTRASA................................................................................ 67
36 -11.800[Z] KOG1840 Kinesin light chain  ali follow..  16  500.................................................KYMESYNTFKSAISKLRATGKKQSTFFLNQMGLACIQLDAIEEAVELFEEAKCIHPETLGLYSNLAGAYDAIGR 584
37 -11.600[O] KOG0543 FKBP-type peptidyl-prolyl cis-trans isomerase  ali follow..  15  244.......................KEQGSVYFKEGKYKQALLQSQKAQAQAFSAAIESCNKALELDSNNEK-----GPFRRGEAHLAVNDFELAWADFQKVLQLYPNNKAARAQLAVCQQRIHR 354
38 -11.500[O] KOG4642 Chaperone-dependent E3 ubiquitin protein ligase (contains TPR repeats)  ali follow..  10  1...........................................MKGKEEKEGGARLGAGGGSPEKSPSAQE-----LKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQQ 75
39 -11.300[R] COG3107 Putative lipoprotein  ali follow..  12  6FSRLKAARCLPVVLAALIFAGCGTHTPDQ----------------STAYMQGTAQADSAFYLQQMQQSSDDTRINWQLLAIRALVKEGKTGQAVELFNQLPQELNDAQRREKTLLAV...... 106
40 -11.200[O] KOG0550 Molecular chaperone (DnaJ superfamily)  ali follow..  8  37................................................KKYAEAIKAYTEAIDLGSDSALAI---YYSNRAATYMQIGEFELALCDAKQSDRIKPDVPKTQSRIRQAYEGLSI 108
41 -10.800[S] COG3898 Uncharacterized membrane-bound protein  ali follow..  10  1.MIRLLAFLIVVFALGLGFAWLADRPGDMVVTFNGYQVSLMVAA-----WLIRSLWNSPYTISRYFRVRRRDRGYQALSTGMIAAGAGDGALARKKTKEAAKLIRSDQEPLIHLLEAQASLLE 133
42 -10.700[R] KOG4234 TPR repeat-containing protein  ali follow..  9  109.......................KAEGNKLFVNGLYEEALSKYAFALELVQELPESIELRSI-------------CYLNRGVCFLKLGKCEETIKECTKALELNPTYNKALVRRAEAHEKLEH 195
43 -10.700[T] KOG1130 Predicted G-alpha GTPase interaction protein, contains GoLoco domain  ali follow..  19  1.........................................................MREDHSFHVRYRMEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDSAIYSQLGNAYFYLHD 70
44 -10.600[S] KOG4507 Uncharacterized conserved protein, contains TPR repeats  ali follow..  8  280..........................................................DAAVVVHAALDDSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQARPGFEQAIKRK......... 335
45 -10.600[V] KOG0624 dsRNA-activated protein kinase inhibitor P58, contains TPR and DnaJ domains  ali follow..  5  305................................................GHISEAIAECNEILND-----DPSDADILCERAEAHILDEDYDSAIEDYQKATEVNPDHREAKEGLEHAKRLKTQ 374
46 -10.400[G] COG2956 Predicted N-acetylglucosaminyl transferase  ali follow..  11  152.............................................QATSEWQKAIDVAERLVKLGKDKQRVEIAHFYCELALQHMASDDLDRAMTLLKKGAAADKNSARVSIMMGRVFMAKGE 229
47 -10.200[S] COG1729 Uncharacterized protein conserved in bacteria  ali follow..  19  250...................................YRNSYQFILSG---DYGTAEQGFRDHISR----RDAKAADAHYWLGESLLGQQKYRDAAEVFLAASKDYPKAKKAPDMLLK....... 325
48 -9.760[S] COG1747 Uncharacterized N-terminal domain of the transcription elongation factor GreA  ali follow..  3  166.................................RQNAAIKEVWTKLVALIPDDVEFFYREQKKISEKLGEGRGSVLMQDVYVYYKENEDWTTCINILKHILEHDEKDVWARKEIIENFRCKYR 255
49 -9.640[H] COG3071 Uncharacterized enzyme of heme biosynthesis  ali follow..  14  296....................................ERLALLIPRLKAGNPEPLEKSLRQQIKQ-----HGATPLLNSTLGQLMLKHGEWEKASEAFKAALAQRPDGYDYAW-LADALDKLHR 376
50 -9.420[M] COG3017 Outer membrane lipoprotein involved in outer membrane biogenesis  ali follow..  14  1MTLPDFRLIRLLPLASLVLTACTLPGHKGPRQHQQEVRHLNQYQTRGAFAYISDDQKVYARFFWQQTGQDRYRLLLTNPLGELELNAQPGNVQLVDNKGQRYTADDAEEMIGKLT........ 126
51 -9.370[M] COG3056 Uncharacterized lipoprotein  ali follow..  19  33PNMFK--KILFPLVALFMLAGCAKPPTT............................................................................................... 58
52 -9.330[O] KOG0551 Hsp90 co-chaperone CNS1 (contains TPR repeats)  ali follow..  8  83.......................KDEGNDYFKEKDYKKAVISYTEG-----------------KKKCADPDLNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIRGALCHLELKH 166
53 -9.260[MP] COG3015 Uncharacterized lipoprotein NlpE involved in copper resistance  ali follow..  12  1MVK-KAIVTAMAVISLFTLMGCNNRAEVDTLS------------PAQAAELKPMPQSWRGVLPCAD-------EGIETSL--FLEKDGTWVMNERYLGAREEPSSFASY.............. 88
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.