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Query: [S] COG4306 Uncharacterized protein conserved in bacteria, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGTYRAAQICTNGHVATTAADQKHELWEAFCSHSGEATILQYPKCSASIRGDDYVEGVLGFGGDYEPPTFCNNCGSRFPWAERKIAGTVELVEAGTDLTPDEVQQFRTDLTQLTKDSPKTQVTCLRFKKVMAKVRTSVASGVRDIVVDVLSEAAKKAILast
1 -59.900[S] COG4306 Uncharacterized protein conserved in bacteria  ali  100  1MGTYRAAQICTNGHVATTAADQKHELWEAFCSHSGEATILQYPKCSASIRGDDYVEGVLGFGGDYEPPTFCNNCGSRFPWAERKIAGTVELVEAGTDLTPDEVQQFRTDLTQLTKDSPKTQVTCLRFKKVMAKVRTSVASGVRDIVVDVLSEAAKKAI 158
2 -17.800[S] COG4640 Predicted membrane protein  ali follow..  13  2............................KSCPKCGQQA--------------------------QDDVQICTQCGHKFDSRQALYRKSTDEDIQTNNIKMRKMVPWAIGFFILI--LRNFNSPEAQTKILVNAIENNDKQKVATLLSKVDSEEAKVYI 115
3 -17.700[S] COG4260 Putative virion core protein (lumpy skin disease virus)  ali follow..  21  325................WTCPECNTKNTGKFCSNCGQAKPSACNECGAVVNLA------------NGVPKFCPECGKPFVAKA............................................................................ 388
4 -15.500[J] COG2888 Predicted Zn-ribbon RNA-binding protein with a function in translation  ali follow..  21  14..............PICSSCGKIIHPREKGCPNCGEVLIRRDHMCRKQ-----------------GAEYICPNCGFKGP............................................................................... 65
5 -15.300[T] COG0631 Serine/threonine protein phosphatase  ali follow..  16  1.............MLICPQCEFENPNANKFCQKCGASLSHKCSQCSTEVPVN---------------AENCHNCGAETGTVWRAIIETKDWASDVSVSTLLSANS..................................................... 78
6 -13.100[TZR] KOG1704 FOG: LIM domain  ali follow..  12  202.............HFQCAQCNDVQRANKPVCLKCFHSSSSTCTTCRLSFSSDTPHMSQGDLHWHASAECFCCVCSKNL................................................................................ 276
7 -12.100[S] COG4307 Uncharacterized protein conserved in bacteria  ali follow..  6  4..............FHCPNCGQRLAFENSACLSCGSALVQLCANCNWLVPSD-------------QLGGLCSSCVLTIERPSDTNTAGLAEFARAEGAKRRLIAELHEL---TGHQNGVITLDLAEGDDVHREQLRVEMDEPYRTLLGHFRHEIGHYY 181
8 -11.900[O] COG3058 Uncharacterized protein involved in formate dehydrogenase formation  ali follow..  11  190................CPVCGSGTTQGLRYCNLCETE-RVKCSNCEQSGKLHYWS---LDDEQAAIKAESCDDCGTYLK............................................................................... 263
9 -11.800[R] KOG4399 C2HC-type Zn-finger protein  ali follow..  12  398..........VAGYKFCEVCDRYVTERNVHCDRCQAGKWNHCEKCDKCVKPRYV---------------HCAQCAR.................................................................................. 454
10 -11.800[O] COG0068 Hydrogenase maturation factor  ali follow..  11  106...............TCPECQREDPFSRFYCTHCGPRLSVMCPECEDSYHDVEN----------HAQPVACHTCGPKAWLERADGKPVTASMFSMLDDVDAVCTLLQKGEIVAIKGDATQEAAVEKLRQRKRRYDKPFALMARD------INVIEKYC 268
11 -11.800[R] KOG3608 Zn finger proteins  ali follow..  11  205..............VACFHCGELFRTKTTLCAQCFKFFATKCTMCDMTCSSASSLTTHIRYRHLKDKPLKCSECDTRCVRESD........................................................................... 304
12 -11.600[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  12  284LSQDQLCVVCSTNPKEI-PCGH-------LCEDCAQKISVTCPVCRGSIVS........................................................................................................... 331
13 -11.400[R] KOG3362 Predicted BBOX Zn-finger protein  ali follow..  16  221.........................PARKFCAVCGIISKYCCTRCGA---------------------KYCSRCMKWLA............................................................................... 263
14 -11.400[J] KOG2613 NMD protein affecting ribosome stability and mRNA decay  ali follow..  12  10.....................QHQNAATLLCCNCGTPIDGSCYDC-------KLTVDITQGIPREANISFCRNCERFLQPPGQWIRAELESRELLAICLRRKVRLVDASFIWTEPHSRRIRIKLTVQGEAMTNTIIQQTFEVEYIVIAMQCPDCARS. 149
15 -11.300[S] KOG4367 Predicted Zn-finger protein  ali follow..  9  156....DRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFY---CDPCRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPV---LEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLLIDALNRRKAQLL 335
16 -11.200[J] COG1499 NMD protein affecting ribosome stability and mRNA decay  ali follow..  9  2.....................AGRDVAKIPCPFCGRLVDRLCEDCYVERHP---------VKVKETRVLRCRYCGA--RWIREGRGGVEELAAKVLSDKASVSGAIERIEASQSYDGLTARVVV-KGSPHPSIEPRLFTYVLTFEYVYDICNSCREM. 135
17 -11.100[O] KOG0006 E3 ubiquitin-protein ligase (Parkin protein)  ali follow..  14  299....MGGVLCPR-GGNGLGCGF------AFCRECKKKTTKPCPRCHVPVEKNG--CMHMKCPQPQCRLEWCWNCGCEWN............................................................................... 426
18 -11.100[R] COG1040 Predicted amidophosphoribosyltransferases  ali follow..  10  18...............RCVLCHGSSGVSDGICAGCRDDLADAANSCPLCFMH-------------VQGGAVCGGC-PAFDRMWASLHYEPPVSNMIHALKHLADLSMVQPLADLMMQNPPDRLADECFDFVL........................... 127
19 -11.000[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  12  23.....ECAVCYS--TTIPSCGH------KFCFIC-VSNNGDCPICRGPIDSQ.......................................................................................................... 70
20 -11.000[S] KOG2990 C2C2-type Zn-finger protein  ali follow..  6  53.............NIWCDGCKNHIGMGVRY-KKVGNRFRMKCHLCVNYIE-----------QTDPANCDYVIVSGAQRKEERWDMADNEQVLTTEHEKKQKLETDAMFRLEHGEADRSTLKKALPTLSHIQEAQSAWKDDFALNSMLRRRFREKKK.. 195
21 -10.900[K] KOG2845 Activating signal cointegrator 1  ali follow..  9  166...........PGRHPC-DCLGQKHKLINNCLICGRIV---CEQEGSG----------------------CLFCGTLVRDSNKSQKLLKKLMSGVENSGKVDISTKDLLPHQELRIKSGLEKAIKHKDKLLEDRTSIRRTQVIDDESDYFASDSNQWL 298
22 -10.800[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  4  324.........CIECKC-CNICGTSENDDQ-FCDDCDRGYHMYCLT--SEPPEGSWSCHLC---------LDLLKEKASIYQNQNSS......................................................................... 391
23 -10.800[S] KOG2989 Uncharacterized conserved protein  ali follow..  9  48.............SMRCLECNEYIPKSRKF-ELLKERLTISCPRCANSIA-----------RTDPGNSDYVMEVGGVRNYVPQKPNDDLNAKTAVESIDETLQRLVREKEMEQNEKMGIKEQADDKMDLLEKRLAKIQQEQEDDEELENLRKKNLE.. 192
24 -10.800[O] KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase  ali follow..  14  82.........CRQQGHIVQDC-PEAKDNVSICFRCGSK-FAKCFICHE--NGHLSGQCEQNPKGLYPKGGCCKFCSSV................................................................................. 159
25 -10.800[S] KOG2660 Locus-specific chromosome binding proteins  ali follow..  13  11...........RACLSCSICDNILRDATTISEKC-EDEIETCPVCNIDL............................................................................................................. 53
26 -10.400[O] KOG1813 Predicted E3 ubiquitin ligase  ali follow..  19  279........ICRE---VVTKCKHY------FCEHC--TKNKKCFVCNQPTMG........................................................................................................... 320
27 -10.400[OU] COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger  ali follow..  20  58....EAAPKCNNGHLKCPHCGATDDPKAIQCSKCDEV-KVQCTLCKSKKHSKER--EKAKPKVLPFHTIYCYNCGGK................................................................................. 170
28 -10.400[R] KOG3002 Zn finger protein  ali follow..  12  71.........CPNGHTLCSSCKLRVQNT---CPTCRYELEVPCRYCQDIFPYYSK----------LKHEQHCRSC.................................................................................... 145
29 -10.400[S] COG3880 Uncharacterized protein with conserved CXXC pairs  ali follow..  7  1..............MICQECHERPATEVHICEQCAKENISACPKCGMTFQ-----------QFRKIGRFGCSEC-------KTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFENAAHVRDQIRLLEQSLKST.. 178
30 -10.400[O] KOG2813 Predicted molecular chaperone, contains DnaJ domain  ali follow..  5  215.........CNNQMMKCSTCYAHKDGSDTICTNCNGKGKLPCPTCQSR----------------------CQTCSTGSLLTSSIAVVKWKTLSKRKVSATRGAGSVPEEVFDRAEGVQLCNTQAYQCTPAYFADSYFLNRFSSEVISLRAEVPPTANV 361
31 -10.200[K] KOG2907 RNA polymerase I transcription factor TFIIS, subunit A12.2/RPA12  ali follow..  14  1MSVVGSLIFCLD----CGDLLENPNAVLG-CSQCKATIKEKCPQCGNE---EMNYHTLQLRSADEGATVFCTSCGYKFRTNN............................................................................ 125
32 -10.200[DR] KOG4739 Uncharacterized protein involved in synaptonemal complex formation  ali follow..  9  4..............IQCNHCGIKPNQTKLYLTACGHVF---CQNC-----------------TKAAFNSQCYLCKKPLKVDEINKNLRPDLMELFKDPRQLASDLVNELKQVVAFQAKQREIYVKCKNAEAKKDTERFAEARSKH............. 114
33 -10.200[DKL] COG5220 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3  ali follow..  6  1MDDEGARK-----DEKCPLCQADRYLNPNMNPECYHKM---CESCVDRI-------------TTGPAQCPTPGCNKILRKAKFREQTFEDAQIEREVDVRKRISRIFNKGQQEFDSLQAYNDYLEEVEILTFNLIYKIDVEETEEKVKQYEKQNRDSI 143
34 -10.100[R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers  ali follow..  19  256........ICKK---IATTCGHH------FCEQC--RKTPTCIQCGADTKG........................................................................................................... 297
35 -10.100[T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa)  ali follow..  13  777.........CL---TRCDHCKQVVE-TEHLLTECDKKGFGKCYRCSEAVFKEEIKHKDCNPAKPEKLANRCPLCHENFSPGEEA.......................................................................... 858
36 -10.000[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  8  186..KVDMVTLC----SVCQRGHSPLSNRIVFCDGCNSPYHQLCPPIDDAT-------------VQDVDAEFCMKC-QPLETGMTAQDLGLSESDKKMYLSSLPTPHLADLILFCEKSYPSLPIYNPRTRELLGEI........................ 308
37 -9.930[K] COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains  ali follow..  14  1.......................................MHCPFCAAV-DTKVIDSRLVSDGSQVRRRRQCLDCNERFTTFEVAELVLPRVIKSDEVREPFNEEKLRRGMLKALEKRPVSSDDVETAISHIKSRATGEREVPTKMVGNLVMEALKRL. 119
38 -9.890[DV] KOG4537 Zn-ribbon-containing protein implicated in mitosis  ali follow..  10  36..................................GQTMLDECPTCSGIL-------------EDRALVRRCVTCELFREKSSVIVGEVSLQDEDLNEAVNNKIPTPAAPVNKPAKKAVLQKSAPAKKKEAVPAAAEPSSSDTIESATTAVLQKLEWA. 147
39 -9.860[K] KOG2462 C2H2-type Zn-finger protein  ali follow..  14  151...............HCPYCEKVYVSMPAYCQFCGKRFSRKCGVCEKAFADKSNLRAHIQTHSNTKPHT-CARCGKAFALKS............................................................................ 245
40 -9.840[T] KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins  ali follow..  12  458..AVEKKAYCEPCYIQCNVCSKPIMEGKAYCVMCHRSLAPRCSVCKEPIPGQEETVRIVALDRDFHVHCYCEDCGGLLSEGD............................................................................ 580
41 -9.800[K] COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB  ali follow..  8  1MVENQKKK--IEEIERCPECGSDYEHGELVCGECGAVIEDSYIDQGPEWRAFDSEQNESRARAGSPMTFTIHDKGLSTDISWKNKDSYGRSIPTRNRAQLYRLRKWQKRIKVSNAAERNLSQALQELERMAFNLS--IPNDVRETAAVIYRKAVKQNM 160
42 -9.720[R] KOG1819 FYVE finger-containing proteins  ali follow..  11  571...............QCTACS------MPFCRNCGRIF---CHKCSCN----------------DRKPVVSSPQSNLSLLTRQDQFSCNLLHQSHHIHHLFNRSLVPHTYP............................................... 658
43 -9.710[O] KOG1814 Predicted E3 ubiquitin ligase  ali follow..  14  257YENDSNIIFCPQKLAICQKCDFA------FCSFCQAT-GQRCPTCDRVVERID-----CCHMNCLCGTHFCFLCGAYLMEQN............................................................................ 404
44 -9.660[K] KOG2857 Predicted MYND Zn-finger protein/hormone receptor interactor  ali follow..  9  3........................PRATQTCEICEKVVSKKCPSCLV---------------------PYCSGCFKIHKVCNLINNAETPCAKPSDPSSTEEKPV..................................................... 64
45 -9.610[S] COG4530 Uncharacterized protein conserved in bacteria  ali follow..  11  4...............................PELGTK--RIDPETGRKF---------------NRDPIVSPYTGKSYPLSFFEETSVAKVLEKEEEEDVKEVDTENTEVELVSLEEADDEASGGD................................ 84
46 -9.610[R] COG1779 C4-type Zn-finger protein  ali follow..  12  4...................................QDMKIDCPVCGGEMTAVTRVEKIPYFGEIMESVLICERCNYRSTDIICLEQKEPSRYIIEAGADTLNARVVKSQSATIVEPGPRSAGYISNIEGVVERFEAALKTALNLFEDDESKKKASKIL 136
47 -9.590[O] KOG0712 Molecular chaperone (DnaJ superfamily)  ali follow..  12  126.....TTKLALQKKVICPKCSGRKEGSVKSCASCNGSMQMTCPDCN-------------GAGETIRDEDRCKECGAKVISQRKILT........................................................................ 211
48 -9.590[S] COG3877 Uncharacterized protein conserved in bacteria  ali follow..  14  5..............................CPVCGKEMIVTCKRDEVTVRGRFRASPFDFLDKDENLKEIERYTGQGYFALRGKLEKILEKMN----LQPLGEMKEEISEEDLFKQVKEGKIGVEEALEILKKRKKGGESDV................ 127
49 -9.580[K] KOG1597 Transcription initiation factor TFIIB  ali follow..  10  2..........................SDAFCSDCKRHTDTVCSECGLVLESHSIDETSEWRTFANESGD--VRVGGPTNPLLADGGLTTVISKPNGSSGDFLSSSLGRWQNRGSNPDRGLIVAFKTIATMADRLG------LVATIKDRANEIYKRVE 137
50 -9.460[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali follow..  12  842...........KNILKCGVCFDRPKEYHLFCQQC-EIRHRKCPGCGTAFGQN.......................................................................................................... 892
51 -9.430[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  9  1..............MPCESCGVE--RRKRACFDCKRYY---CANCIAS--------------------RRCKRC--------------------------------SVFAQRPLSRTDLLKLKPKDLIFYLQSKHISTEGCLEK-LVGLVLTHV.... 88
52 -9.420[R] COG1645 Uncharacterized Zn-finger containing protein  ali follow..  13  30..................................GGTMLAECKVCGAPK-------------FRYQGTVICPICDVREEGEETPAPEPAAEVQVPEARSSPERDRPSPEQDRSSPERGRVPAERDR................................ 109
53 -9.370[J] COG0143 Methionyl-tRNA synthetase  ali follow..  13  112......TRLKENGFI------KNRTISQLYDPEKGM-VKGTCPKCKSPDQYGDN----------------CEVCGATYSPTELIEPKSVVSGATPVMRDSEDLPSFSEMLQAWTRSGALQEQVANKMQEWFES......................... 225
54 -9.360[R] KOG2858 Uncharacterized conserved protein  ali follow..  13  2...........................AVLCGVCGIKEFKKCPRCLV---------------------QTCSEC----------SKKHKTRDNCSGQTHDPKEYISSEALKQADDDKHERNAYVQRDYNYLTQLKRMVHVQKMD.............. 89
55 -9.330[R] KOG3183 Predicted Zn-finger protein  ali follow..  11  9LGKHCSVDYCKQ--FTCDRCL------QVYCLDC-DVTVVICPLCAKGVRKKKCPVPRCRELLTFSNTIKCRDCSIDH................................................................................ 125
56 -9.330[R] KOG0490 Transcription factor, contains HOX domain  ali follow..  14  29.........C----VQCCECKTNSREGKLYCKN--RRFGTKCAGCAQGISPSDLVRKARSKVFHLNCFT-CMVCNKQLSTGEE........................................................................... 104
57 -9.290[D] KOG3056 Protein required for S-phase initiation or completion  ali follow..  13  475..............VICQVCKYTAFSASDRCKEQKHPLKVQCKDCGNRT-----------TTVFKLPKQSCKNCKGSRWQRTAMIREKKILTGRETLSVRGDEETFMGCLAG.............................................. 569
58 -9.290[TZ] KOG1044 Actin-binding LIM Zn-finger protein Limatin involved in axon guidance  ali follow..  12  29.........C----FACTICKRPFPPGDRVCAGCGRDIKNKCKSCGKVLTGEYISKDYCEKDYQGLFGVKCEACHQFIT............................................................................... 141
59 -9.230[S] COG5349 Uncharacterized protein conserved in bacteria  ali follow..  15  2......................ADASYPNAPTPIRAGLKCCCPRCGEG------------FQGFLKLAPACDQCGLDYGFADP........................................................................... 52
60 -9.220[B] KOG0457 Histone acetyltransferase complex SAGA/ADA, subunit ADA2  ali follow..  7  8.....................SNDPSDKPPCRGCSSYLMEKCAECGPP--------------------FLCLQCGFEYKKHQSDHTYEIMTSDFPVLDPSWTAQEEMALLEAV------MDCGFGNWQDVANQMCTKTKEECEKHYMKHFINN..... 121
61 -9.210[K] KOG2461 Transcription factor BLIMP-1/PRDI-BF1, contains C2H2-type Zn-finger and SET domains  ali follow..  4  565...............RCDICDKRFSSTSNLCDVCDAKFTQSCGTCGKKYISPSTTCKEEDMKDSMDIKGEIDEGSMSGSGYGN........................................................................... 676
62 -9.200[KL] COG5151 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1  ali follow..  9  306....RGGFHCPRCKAECPSCSLSANPKSTHCFACQLPFPKACPSCKN------HFCLDCDVFAHEQL-HECYGCQCSGN............................................................................... 421
63 -9.200[KL] KOG2807 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1  ali follow..  9  306....RGGFHCPRCKAECPSCSLSANPKSTHCFACQLPFPKACPSCKN------HFCLDCDVFAHEQL-HECYGCQCSGN............................................................................... 421
64 -9.090[O] KOG0826 Predicted E3 ubiquitin ligase involved in peroxisome organization  ali follow..  15  243...............ECPVCLLSSVSGYVFCWKC-MKEHGTCPVTHYPISLDD......................................................................................................... 290
65 -9.090[K] KOG2393 Transcription initiation factor IIF, large subunit (RAP74)  ali follow..  23  11..............................CVGCGSQSDLYGSSCRH--------------------MTLCLKCGRTMAQNKSKCHECGTVVT................................................................. 53
66 -9.060[C] KOG3256 NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit  ali follow..  10  112........................PSGEERCIACKL-CEAICPAQAITIEAEERADGSRRTTRYDIDMTKCIYCGF-----QEACPVDAIVEGPNFEFSTETHEELLYNKEKLLCNGDKWESEIASNLQA............................ 212
67 -9.060[K] COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS  ali follow..  15  1..............MFCPKCGSTPVNGRYVCPSCGLDSDAICPRCHHK---GARYVLKQTRSADEPETKFCEECGYR................................................................................. 96
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 1 0 5   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;