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Query: [O] COG4346 Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVKEAKLNDYMGDEVWYVSSTRNILHLLGINVSYVENGSVGVNVFLKEPLYVGKVRVKFLGITLEKPVREAPQIPEFAEKLGVTVEYYPFNYTRNESQWEDLKLRIWEVAERNSFVEYYSYSNFPGVFYRIPVENYKNFTEELREIGNITIIPGYKYPDEENIHKYLNTEHPFLGKDIIALGMLIEDKPFYWRIPGIIEHALIVIIVTLVAYKITKSYLASSIAATFAALDPLLFATGIVAMLDIHVAFFIALFMLFLALDRIRLSGIALGLAAATKLSGAFAFPILWFKILKEKDLKEYLISGLVLPMVSFLIPEITIIKAIGFIPWLEEFIASFSWHLSFKGEHPSEAPFWMWFVSLKPFPFHFDPDVYAVTDPILMISMIVFVFAVPYVSLRRKGLSEIFWMFWSIIAFFALQYILGGKTQFIFYATPLIPPGAVALGVISYEIIKWEYFERSLRIYLNYLRSIAKPLKKVIKRLast
1 -132.000[O] COG4346 Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase  ali  100  1MVKEAKLNDYMGDEVWYVSSTRNILHLLGINVSYVENGSVGVNVFLKEPLYVGKVRVKFLGITLEKPVREAPQIPEFAEKLGVTVEYYPFNYTRNESQWEDLKLRIWEVAERNSFVEYYSYSNFPGVFYRIPVENYKNFTEELREIGNITIIPGYKYPDEENIHKYLNTEHPFLGKDIIALGMLIEDKPFYWRIPGIIEHALIVIIVTLVAYKITKSYLASSIAATFAALDPLLFATGIVAMLDIHVAFFIALFMLFLALDRIRLSGIALGLAAATKLSGAFAFPILWFKILKEKDLKEYLISGLVLPMVSFLIPEITIIKAIGFIPWLEEFIASFSWHLSFKGEHPSEAPFWMWFVSLKPFPFHFDPDVYAVTDPILMISMIVFVFAVPYVSLRRKGLSEIFWMFWSIIAFFALQYILGGKTQFIFYATPLIPPGAVALGVISYEIIKWEYFERSLRIYLNYLRSIAKPLKKVIKR 477
2 -50.600[O] KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase  ali follow..  12  66...........................................................................................VMPVIFTALALFTRMYKIGINNHVVWDEAHFGKFGSYYL--------------------------------RHEFYHDVHPPLGKMLVGLSGYLAGDYVKMRLFNASFSALCVPLAYFTAKAIGFSLPTVWLMTVLVLFENSYSTLGRFILLDSMLLFFTVASFFSFVM-WLLITGISLGCTISVKMVGLFIITMVGIYTVIDLWTNHWLARIFGLIIVPFCIFLLCFKIHFDLLS-LAMMATNNALVPDPDKFDYLASSAWQWPTLNVGLRLCGNPKYFLLGTPASTWASSVAVLAFMATVVNWNVFLMGGFYPLLAWGLHYMPFVIMSRVTYVHHYLPALYFALIILAYCFDAGLQKWSRSKCGRGFMALVIGCFWYFSPISF. 732
3 -49.700[O] COG1928 Dolichyl-phosphate-mannose--protein O-mannosyl transferase  ali follow..  12  3...................................YRVATGYSEKSTDDDLIWRTPIVKEELEDADNFLKDDAELYDKVKNESAVSHLDTIVMPIIFTVLGMFTRMYKIGRNNHVVWDEAHFGKFGSYYL--------------------------------RHEFYHDVHPPLGKMLVGLSGYLAGDYVKMRLFQAMFSSLCVPLAYFTGRAIGFSRLSVWLFTILVIFENSYATLGKFILLDSMLLFFTVSSYFCLAKFWLCLTGLNLGCAISVKMVGLFIISVVGIYTISENHWLARIFGLIIIPVCVFLLCFKIHFDLLSFRNFMQLNSAMMATNNALEKFDGIASSAWQWPTLNVGVRLCESIKYFLLGSPASVWPSSIAVCALIIHVIERDVFVMAAFYPLLAWLLHYMPFVVMSRVVYAHHYLPTLYFALMILSYYFDMITKRWATRNTGKVYGSIVIAGFFYFSPFSF. 726
4 -36.700[M] COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family  ali follow..  13  12.................................................................................................................AFIACYYLLPISTRLLWQPDETRYAEISREMLASGDWIVP--------HLLGLRYFEKPIAGYWINSIGQLFGANNFGVRAGVIFATLLTAALVTWFTLRLWRDKRLALLATVIYLSLFIVYAIGTYAVLDPFIAFWLVAGMCSFWSAGFLLLGITCGMGVMTKGFLALAVPVLSVLPWVATQKRWKDLFIYGWLAVISCVLTVLPWGLAIAQREPNFWHYFFWVEHIQRFALDDAQH-------RAPFWYYVPVIIAGS--P--------LGLLPGALYTGWKNRKHSATVYLLSWTIMPLLFFSVAKGKLPTYILSCFASLAMLMAHYALLAAKNNPLALRINGWINIAFGVTGIIATFV.. 362
5 -34.100[O] COG4745 Predicted membrane-bound mannosyltransferase  ali follow..  10  14...........................................................................................AAVVAVTAAALLARLWALGWRVA------------------DEARVADWTLQYMDLGAW--------------QYRPIIHGPFLPHVNGVVFVFGATDFTMRLVVAVVGGLLPLTAWLYRTRLSDV--EVGALAVLLAANPVVLYYSRFMRNDLLLAGFMFTAVGLFVRRYLYASAVPFALAFTTKENSLLYPLCWLGALALVTDDRWRAKAALAGSALTAAVIVVSFYAPKPDLYRLFEQPGRAPAVLEAATIGTYHEFADLWASTSTAFLSHDLSVLVACGTVVS----VAAVVGYLANRYATETPRPLVSFAFYWGVFSVLGYPAVVDIAAAWTAVNALVPLAIPAAVGVGAVVRYGRRGAAAGDTAAVRLAVTVLVVSAA.. 401
6 -25.500[S] COG5305 Predicted membrane protein  ali follow..  11  46.........................................................................................................................................................................NHPPLYFVLVHLWMLFPNSLLAARSFPALLGAVSIPLTYILGRLAFRSSLVGQLAAGMMAVSPYAVYLGQEVRHYTLAMIWVIASLSCLVIWLIILWVGINALGIATHYFFTLTLCAEALVLIFLAWQQSTQAKTLVFFSPLWWRIYAVAAGTAV----------AGLVWLPSILENRYRSSLTAWIQVQGIGLHLINP-IESSQLAVVIASGLVMLIFAIWATLQQPQTSLATQVFIGVVLGAIALFFRGARYNFVYF-----PAVIILVGASLAVYWQTSKKAVMIIWLMGFVSAVTVICNLGYQK 393
7 -25.200[S] COG5650 Predicted integral membrane protein  ali follow..  13  127........................................................................................................................................................................MEYPVLGGIFQWICGIITRFTLPESGLYFIVTALALAFFWVLVIRMMVELTGNRVWDTVLVAASPLVAVHAFTNWDTPAIAAVIGAMLAVKRGNPLVAGVLIGAGTAFKLWPLYLLGAYLVLAVKNKNLKPFITMAAAAAVTWLVVNVPVMIAY-------KAWNEFLRLNRERGAEW--------YQVIDRNLPINLNDPVLLNVLSFGLFGASCVAILILGLKVQRTPR------VAELAFLIVAAFLLFNKVWSPQYSLWLVPLAVLAF..................................... 392
8 -20.100[S] COG5542 Predicted integral membrane protein  ali follow..  8  90.........................................................................................................................................................WDAIYFVDMAVNGSLFEQ-SLWPKIISFLAFRSKDVVLLGIVSCFASAIACYALYLLTKSIFSNQKMTAYTVIFYCFSPSGIYMS-VGYTESLFAAFSFLGLLLFIKKQQYPAAFLWSLATLIRSNGIFWCIFFGMPAIGTLKISLERLQLTFMQVSQLVGYGTKCLIILVPFFYNQYLGFKLFCPGVAWCNKSLPLIY--WNVGFLRYWTLNNIPNFLFALLSII---PILFALFYSISGSTLHSFRSIKSHLVLSALYLYIGCFHMHTQVLNRMSSALPLLYWSMAHATLYAKSRNLKAFGHCILFVWIAGLYGSFLP.... 424
9 -19.200[O] KOG2292 Oligosaccharyltransferase, STT3 subunit  ali follow..  13  80............................................................................................................................................................................PLGRTSGGIHWLLHVLNIPCVFLAPIFSGLTSISTYLLTKELW-SAGAGLFAASFIAIVPGYISRSVAGSYDGIAIFALQFTYFLWVRFWSAAAALSYFYMVSA-WGGYVFIINLFVLLIMGRYSPRLLTSYSTFYILGLLFSMQIHMAALGVFVLLMAVATLRHLQSVLSRNEFRKLFIVGGLLVG--FYSLWDTGYAKIHIPIILHILVCAFPVGVWYCIKQINDERVFVVLYAISAV----YFAGVMVRLMLT---LTPVVCMLAGVAFSGLLD............................ 428
10 -18.700[MU] KOG2516 Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family)  ali follow..  6  95.............................................................................................................................................................................VVRGIVGLTNGLSFIYLKNCLQDMFDEITEKKKEENEDKDIYIYDSAGTWFLLFLIGSFHLMFYSTRTLPNFVMTLPLTNVALGWVGRYNAAIFLSALVAIVFRLEVSALSAGIALFSVIFKKISLFDAIKFGIFGLGLGSAISITVDSYFWQEWCLPEVDGFLFNVVAGYASKWGVEPVTA---------YFTHYL-----RMMFMPPTVLLLNYFGYKLAPAKLK----IVSLASLFHIIVLSFQPHKEWRF-IIYAVPSIMLLGATGAAHLWENMKVKKITNVLCLAILPLSIMTSFFIS. 380
11 -18.100[R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation  ali follow..  9  85............................................................................................................................................................................PLGRMVTSGIIFKVLHLLRINLLAPAFSGITAIATYYLARELK-SDACGLLAAAFMGIAPGYTSRSVAGSYDAIAITLLMSTFALWIKAWGACTGLLYFYMVTA-WGGMIPLHVFVLLLMGRYTSKLYIAYTTYYVIGTLASMQVPFVGFQPVSTSEHMSALGVFGLLQLFAFYNYVKGLVSYAKIHIPIIASVSEHQPPTWSSLFFDLQFLIWLLPVGVYLCFKELRNEHVFIIIYSVLGT--YFCGVMVRLVLT---LTPCVCIAAAVAISTLLD............................ 433
12 -16.900[MU] KOG2515 Mannosyltransferase  ali follow..  8  71.........................................................................................................................................................................FYIALHAVPGFLARGLGLSRYFIRGVLACFSAFCETNLILAVARNFNRA-VALHLTSVLFVNSGMWSASTSFLPSSFAMNMVTLALSAQLRTVKVVSFITIGAVIGWPFSAALSIPFILLELVDLKGRFRHLFCRWFKAIFLLITGICITVDSLFYHRIQFVAWNIVKYNVLAKDGR-YGTEPWWY--------YFANLSLQHNIVLWFAMACGPLVLLAAFTNWINLDSFLDLSSVISPFYIWLFIFIIQPHKEERF-MYPIYPVLCLAAAIGLDMSLKLMIQILSSINETVRSKFPVRFVVLCV.. 381
13 -16.200[S] COG4713 Predicted membrane protein  ali follow..  12  114.........................................................................................................................................................................IYSDIVYIPQSIGINLAK--YFGRIANLICWTIIVFFSVKLIPF-------KKNLMAFLALTPMNLYQAASLSADAMTNSMAFLSIALVLRRQIVTMIIAFTLLAFSKRIYFVMCILFFIIPIKKFNSKKDYIGTFVIMLGACLMSLVTVSVISKILAIKVSAGSYTPGQMEFVLSHPITYIHILLRTFHFKMSFYAISFIGVFG-PLNLYLFYGVALVLIALFEHTLIEKNKIINVGLIMSALYVSWTPKAANIIE-YFIPIIPLLGCFIGVKANKS---RNVYSKVVLAISTFTILTYSVLQLLLR 449
14 -16.200[G] KOG3893 Mannosyltransferase  ali follow..  6  491........................................................................................................................................................................YRYTPMLAILLLPTQYGFPS----KYLFSISDLIAGWLMIKLLSRRISYKRSLIYSSFWI-LNPFVAIISTRGNCEAILGILSIALLYLIEKKSVWLASLILGFSVHFKIYPFMYGIAFLVYFSKPKKGSTFMEKFLLKIVVGSLFMFTICNLLMYYLYGSPFLEHTYLYHFGRTDHRHNFSLHH----------LNLYYESSFGAKASSLFAFLPQLSLCMLIPLVFGKKN-----LPGTLFAQTFAFVTFNKVCTSQYFMWYLVFLPLVL..................................... 751
15 -15.800[S] COG3463 Predicted membrane protein  ali follow..  11  72.........................................................................................................................................................................VHFQPILLLLLPVYAIMPSPVVLLLIQAIFLALSATLALLIACEELNHREAILVASLYIFNSSL----LGIALFESLAVPLFFIAYMLLKRGKMKLFYLTSVLILLTKEDSFLGVVSLSLWKILMDGLNPESFRKNRGLILLSIASMMYGIIVIKVVIPHLGMGYIYESLYSEFELTRRKL--------------------------------LYFIVFNASFGFLTFLSSKGLVSVALPWLESMLSSRDTQTMIGFHYPYMLLPLSYLVAIEGFKKSKKVAVSLIVAGILTSMATIPITFK...... 341
16 -15.200[S] COG5617 Predicted integral membrane protein  ali follow..  9  66..........................................................................................................................................................................YPPLSYLTAGVLGKVLGSDTGYAATLMLTSFLGALALHHYLKSTGRE---PCISPLIFLLFPWHLSYIEGNFPRANAIHLAPLFLLSLYWRYLIASALGISIVALTHYSILPLLIITGILILWDDLRTMTALGNGIKVLGAVIGLTSFWYVPFLFDKKWVEFWNISENKALFKSFSLNPTL---------------------LKSPFGILLILLLLIFAIFAIKNLVDRKKVILAGLYLYLSLGTTWLYSFPLLSIVPPYRWFDLEALIIPLLIGESLKRVQRKSMVALVIIPFTVLAFMNVPKINP 361
17 -15.000[R] KOG2647 Predicted Dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  12  78.........................................................................................................................................................WDSVYFLRITECGYEYEQ-PLLPFFISLLSRTVFAPLV--TVSNLAFIFAAIYLFRVSVIILKDTEASFRASIIFCFNPASIFYS-SIYSESLYALFSIGGVYHLLSGTSNVGVLWFALSGCARSNGILNAGYICFQTMHRAYEALYQKRRAYLAMQVFIAGFLRCICICLPFVAFQAYGYYNICHGHTRDEVR------PWCKGRIPLLYNFIQKILVS-----------------------------------DRGVGFLKYFQFKQL----NFLLASPILSLAVCSIMSYMKS............................ 344
18 -14.900[MO] KOG1771 GPI-alpha-mannosyltransferase III (GPI10/PIG-B) involved in glycosylphosphatidylinositol anchor biosynthesis  ali follow..  8  87................................................................................................................................................................................................KLLQGTFAAILDYGTYKFALVRYGSK-TANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYSSLLGFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSFVLCVSLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYL--------------SQALPLICGGFLPFVLLTMDL------------QTAGTILCVFFPYSLIGHKELRF-VYPISPILLTLAGKFFSSFSSWKRAARFFFLIG-LGHALVITFLCRFHQ 378
19 -14.800[G] KOG4123 Putative alpha 1,2 mannosyltransferase  ali follow..  9  38........................................................................................................................................................................YVHP------VMTGDHFREHTRTWRLIYTLISFSNDYCLFRICRLYGLRFEIRLL---AMGSSWILLVFGTRTFSNSLEMAMCSWLLCLV-LQHLMAMSTICVAGVFNRPTFLLFGAPMVFFWLLRGMGTRSFRDFNLRIALFCLCALPALVLFIFCDSLYYQHLTLGELHMMHLSIDNFVFTPWNFIKGVHPCYVHLMVNM-----PMLFNVLALASLGAFAQLLLRPRFQSIVSLMSGAIFVPLFFLSLINHQEPRF-LLPVTFPLILLHAPKLITGFSAKASGPYLLKIWYVSNVALTLFFGFIHQ 476
20 -14.600[GE] KOG2575 Glucosyltransferase - Alg6p  ali follow..  10  91..........................................................................................................................................................WYRNGTYNDLTYWGLDYPPL-SYIHGIFLRFFNPES-MRWTVLSSDAFIFFPAALFFVLVYHRNRTRGGKSEVAWHIAMILLNPCLILIDCISLGLTVGAIAAVLCESEVLTCVLFSLALSHKQMSAYFAPAFFSHLLGKCLRRKSPILSVIKLGIAVIVTFVIFWWPYSLDDFLMVLSRLAPFERGI--YEDYVANFWCTTSILIKWKNLFTTQSLKSISLAATILASLPSMVQQIL--SPSNEGFLYGLLNSSMAFYLFSFQVHEKSIL----MPFLSATLLAL--------------KLPDHFSHLTYYALFSMFPLLCR 419
21 -13.000[R] KOG2552 Major facilitator superfamily permease - Cdc91p  ali follow..  13  79..........................................................................................................................................................................GSPLLLSILGPLTVQSDKFVVAGSKGNRVIICADLLSALLLRAIGQKLPCGDIAALVYLWNPFTILSCVGLSTSPIENLAVIVSLYGAVTRRVPLAAFGLIMATHLSLYSAPLVFPLIFLLGYGLSWRTVLHFVFWVLVWSSYVLVLCSLSLKQYGGLEEMFKRTYGFILRIEDLSPNIGVFW----------YFFAEAFEFSRNYLLIIFNLYILLTSISLMFRLKHRPCFLAFAYLAFTSILKSYPSVGDAALYLSLWALFVIGFSLLSPVMHNFWIWRGTGNANFYFGNAMGFVEKSVNAMLNH 460
22 -12.300[G] KOG2762 Mannosyltransferase  ali follow..  9  101.........................................................................................................................................................................VYPAGHVLIYKMMYWLTEGMDHVERGQVFFRYLYLLTLALQMACYYLLHLPPWCVVLACLSKRLHSIYVLRLFNDCFTTLFMVVTVLGAIKSLALVISATYSMAVSIKMNALLYFPAMMISLFILNDANVILTLLDLVAMIAWQVAVAVPFLRSFPQQYLHCAFNFGRKFM------------YQWSINWQ----MMDEEAFNDKRFHLALLISHLIALTTLFVTRVLNANPAKTIPFVLIASNFIGVLFSRSLHYQFLYHWTLPILI........................................ 386
23 -12.000[S] COG4906 Predicted membrane protein  ali follow..  10  246...........................................................................................................................................................................GPVYSLILNMWIV-----PIFKIIYPLVFSLVPVILLKAYERLLGNKIWAELSVLFFMFFFQFFVSNMALARMMIVEVYLALLAYATIRKINPLFLILFLASLASHYGTAYLTMFALLTLPLIRVLENEQRISNKLIAVFWVVTLLWYAYVGGGFQFNNLVIIGYQTLLMLKDLFNPQYSQGLELIVAKMTFMREIAKLINLFAQGLISIGVLTVLNRLIRGRKVKHLEFYALFFAYDIAGIVVPYFSNR--LYHLTQFFIAPYLLISVKRIMNNLSKNRHTLPLKNSVEIAGVFLVVYFI..... 551
24 -11.700[S] COG3815 Predicted membrane protein  ali follow..  14  51..........................................................................................................................................................................HQMPQRSFFIFGHKM---AVCARCFGIYTGVLVGMIIYPFIKKLDDFKIPNKWYLIIALI----------MAVDGTTQLIGLRESFNELR---FITGFIAGFTV-----VFYILPIF.............................................................................................................................................................................................. 147
25 -10.800[K] KOG2576 Glucosyltransferase - Alg8p  ali follow..  8  54....................................................................................................................................................................SEWTLDYPPF-ECVLSWIAYFFGFDK-QRGSVIVLELVLLFALREYVLSSNVKDIDIFLSPGLLIIDHIHFQYNGFLF-------LLLWSIVLAKPEKMLLSAAIFSALICFKHIFLYVAPAYFVYLLFTPNFRPQFLNILKLGSTVISIFLLAFGPWIYMKQIPQLLSRLFPFSRGLCHAYWAPNFWALYSFVDRVAFAVLPRFGYALNQGTFYICLGLQITVLIKLFIKPTWRVFVGAVTLCGWISFLFGWHVHEKAIL----MVILPFSILSL-----------IDRRYLEAFRPLAVSGYLSLLPLLFT 404
26 -9.720[OKIT] KOG2642 Alpha-1,2 glucosyltransferase/transcriptional activator  ali follow..  11  74...........................................................................................................................................................................PP-ALYVISMPLCFFAIPAFCRFRRMFVRVRIPTLKIYLKNTD--LQQDVWLTASIVGMLPILISSSILFYTDLLSLTSVIWGFSI---GNPIASAFLFLISILTRQTNIIWAAIYAFSVIASRIDKSRSKMENLKIIISTAFSLWPFITLAIG------FAMFIYFNDFQIVLGDAKAHQPK--FHVAQFFYMV----------FCAAHTWTQIIPNLLSHLRHLTDMKSLVLQAVVAVLVYYPYLLADNRHFTFYIW-LAPLYVFSLRFMTTSTPSVHIFHKILFIIASLLVLVPAHLFE.... 380
27 -9.040[S] COG4485 Predicted membrane protein  ali follow..  9  73.............................................................................................................................................................................LGLNFYALSSYYLGSFLAP-TTLLKFGLIGLSTFFSLNKLFQSPQILKLALSTSYALMSFTVSQLEIKTLDVFILILIITGL-LITEKKLLLYFTSLSILFIQNYYFGYMTVLFLIFWYLFKTRKSSVLDFIVISFLAGMASLIM---------TLPTLFDLQTHGEKLTEVTKFQTESSWYLDLFAKQFIGSFDTTKYGAIPMIFVGLFPFILTILFFTLKSIKFHVKLIYVIFFAFLIASFYIEALDLFWQGMHTPIFSTLLIYTAAEVLKRLKELKVWNFLVSLFLVVAGFLATIY..... 396
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.