current user: public

If you have questions about the server, please let us know.

Query: [E] COG4448 L-asparaginase II, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350
# Score Template Links and tools%idFirst MHRKISCGINDIKSEFFEAERMNNSVTVEVTRGNLVESRHQGLAVVVDGDGGVLFSAGDIERGIFPRSACKAMQALPLVESGATDAYGFGNRELALACSSHSGEDAHAELAAAMLAKAGRDVDTLECGAHWSSDQKTIIHQARTLEKPTALHNNCSGKHSGFICACCHTGTDPKGYVGYDHPLQRQIRATMESLTGAALGHDNCGVDGCSIPTYAVPLKGLAHGFAKMATGRGLEAERAKASRRLIEACMAEPFYVAGTGRACTKLMQIAPGKIFAKTGAEGVFIAALPNQGIAMAVKCEDGTTRAAEAMVTALLARYFDDGSAEQQALKGMANRQMRNWNGIHVGDISVIGLLast
1 -121.000[E] COG4448 L-asparaginase II  ali  100  1MHRKISCGINDIKSEFFEAERMNNSVTVEVTRGNLVESRHQGLAVVVDGDGGVLFSAGDIERGIFPRSACKAMQALPLVESGATDAYGFGNRELALACSSHSGEDAHAELAAAMLAKAGRDVDTLECGAHWSSDQKTIIHQARTLEKPTALHNNCSGKHSGFICACCHTGTDPKGYVGYDHPLQRQIRATMESLTGAALGHDNCGVDGCSIPTYAVPLKGLAHGFAKMATGRGLEAERAKASRRLIEACMAEPFYVAGTGRACTKLMQIAPGKIFAKTGAEGVFIAALPNQGIAMAVKCEDGTTRAAEAMVTALLARYFDDGSAEQQALKGMANRQMRNWNGIHVGDISVIGL 353
2 -6.660[O] COG3531 Predicted protein-disulfide isomerase  ali follow..  14  89...................................................................DSEPPITAALAAQAIGGRGLDM--HRVQRAHYEEGRRIADAPVLRELAVDLGLPADVFDAECARQSGALTQQHIAASQGYPTFVLEDGEGRMDVV---------DAGAWLGRPEAWAQALAQHLAAAAGVHEAAPACGPDSCALP............................................................................................................................................. 238
3 -6.430[E] COG2066 Glutaminase  ali follow..  15  51...........................................IAVFTNQGEV-ITAGDAQEGFSIQSISKVLSTLAMGLYQPDELWSRVGKE--------SGQAFNSLIQLEMEQGIPRNP--INAGAIVVCDMLQSRLSAPRQRLLEFVRQLSGEPQIAY-MMHSDRNAAIAYLMRSFGNFHNEVIPVLHNYFHA-----------CALKMSCVELAKTFSYLAN-VSVVTGETVITPTQSKQTNALLATCGLYDGAGEFAYRV------GMPGKSGVGGGIIAVVPGE-MTIAV--QSGNSLAGTRALELLAQRIGR................................. 313
4 -5.710[S] COG5483 Uncharacterized conserved protein  ali follow..  12  107.........................................................................................EKHTSVLMCREENWRHCHRQFLADFLVERGRRVLHIRSRGALEEHVKTSCYGAFRLPPVELVKRVYQDFGHLCQTGPVYLFGGALEGSTADIDVVIYGVGEAQFIPAPRADLFHFHVTYNGV----------------LICGKPLVIPFEQSLLNELAETEERVFL----------YLNSRDPVVVCKAAKELAFAAA--------AVLCGPGAAT----AVKKCLKNYGVKPPDGFKRCLTPPSLSELRKYREVVEKLASF.. 339
5 -5.360[G] COG2376 Dihydroxyacetone kinase  ali follow..  15  51...........................VSLVSGG--EPTHAGFV----GEGALDAIAGAIFASPSTKQIYSAIKAVE------------SPKGTLIIVKNYTGDIIHFGLAAERAKAAGMKVELVAVGDDVSVGKKKGSLVGRRGLGATVLVHKIAG-------AAASHGLELAEVAE------------VAQSVVDNSVTIAASLDHCTVPEAILGENEYEIGMGIHNESGTYKSSPLPSISELVSQMLPL--MVNNMGGMSNYAAEVISEQLIDKYQIVGAFITALNGPGFGITLMNASKAGGDI.............................................. 331
6 -5.360[G] KOG2426 Dihydroxyacetone kinase/glycerone kinase  ali follow..  15  51...........................VSLVSGG--EPTHAGFV----GEGALDAIAGAIFASPSTKQIYSAIKAVE------------SPKGTLIIVKNYTGDIIHFGLAAERAKAAGMKVELVAVGDDVSVGKKKGSLVGRRGLGATVLVHKIAG-------AAASHGLELAEVAE------------VAQSVVDNSVTIAASLDHCTVPEAILGENEYEIGMGIHNESGTYKSSPLPSISELVSQMLPL--MVNNMGGMSNYAAEVISEQLIDKYQIVGAFITALNGPGFGITLMNASKAGGDI.............................................. 331
7 -5.180[S] COG4273 Uncharacterized conserved protein  ali follow..  17  33..........................................................................................................................................................CSGASVGKIGHEVGVLLTKAGEAARLCCTTAVAAGSEMHLDIGRRARRVIVIDGCPMKCATKVIQKAGFGIAKQPTLDISEEDVLKVALAIAEKVGI...................................................................................................... 141
8 -5.000[R] KOG2316 Predicted ATPase (PP-loop superfamily)  ali follow..  10  9...........................................................................................................................................................GGKDSCYMMQCIAAGHQIVALANLRPAENQVGSDELDSYMTVGHHAIDLYAEAMALPLYRRTIRGRSLD-TRQVYTKCEGDEVEDLYELLKLVKEKEEVEGISVGAILSDYQRIRVENVCKRLNLQPLAYLWQRNQEDLLREMISSNIQAMIIKVAALGLDP-GKTLDQMEPYLIELSKKYGVHVCGE--GEYETFTL 210
9 -4.980[E] KOG2786 Putative glutamate/ornithine acetyltransferase  ali follow..  12  80...........................VQVSRQTLNGCGGKDIHCVVFNSGCANAVTGEGGLMDAQLITAEADNLTRPHWT-SWTENSEEFPSSLVMSTGVIGQRLKLDKIQSAVEDLGSTHEYWMRAAEAICTTDTFPKLVSRELSIAGKVYRIAGKGAGMINLATLLGLFVTDAPISVDAVRSILRHAINNSFNS------ISIDGDTSTNDTIAF--LANGAAGGSEITKSSPAYKEIRDAVTDIAQQLAKLVVRDGEGATKFVTVQVRGARSEKDAALVASTISNSALVKTAFFGEDAN---------RILCAVG.................................. 363
10 -4.920[D] KOG0642 Cell-cycle nuclear protein, contains WD-40 repeats  ali follow..  462.......................................HFDGILAFHPIEPVLITASDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNID-------PSVLRGPLLGHTDAVWGLAYSAAHQ---RLLSCSADGWNTTE-LSVFNDIKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQ-------INRVISHPTSITAHEDRHIKFYDNNTGKLIHSMVAEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVA.................... 759

FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 6 1 8   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster

Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24