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Query: [S] COG4485 Predicted membrane protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKSFLKTYRTYFISFIIPVVIMSGVYLSQSIYWNSDNSPLLGDGFHQYVIFDVALRNILHGNSNLFYTFTSGLGLNFYALSSYYLGSFLAPLVYFFDLTNMPDAIYLTTLLKFGLIGLSTFFSLNKLFQSIPQILKLALSTSYALMSFTVSQLEIKTWLDVFILIPLIITGLHLLITEKKLLLYFTSLSILFIQNYYFGYMTVLFLIFWYLCQISWDFKTRKSSVLDFIVISFLAGMASLIMTLPTLFDLQTHGEKLTEVTKFQTESSWYLDLFAKQFIGSFDTTKYGAIPMIFVGLFPFILTILFFTLKSIKFHVKLIYVIFFAFLIASFYIEALDLFWQGMHTPNMFLHRYAWIFSTLLIYTAAEVLKRLKELKVWNFLVSLFLVVAGFLATIYLKSHYSFLTDLNILLTLEFLVVYSLLLLAVIKKFISVNLFAILISLFILVEMSLNASSQMDGIAKEWGFASRSAYSRDIPAMESFSTYIGNQFTRTEKLQTQTGNDSMKFNYNGISQFSSVRNRSSSSTLDKLGFKSSGTNLNLRYANNSILADSLFGIQYNISDSPIDKYGFKDIYQKDNLTLYENQYSLPIAVASQSVYNDVKFNEHTLDNQASFLNQLANVNFDYFSPIPYEKTEKIENTNDLISVTSSSNEDAAIQYQIEVPENSQVYLSFINLHFSNDKQKKVDILVNGEKKTFTTDNVFSFFNLGYTKEKKTFNINVSFPGNSQVSFESPTFYRLDTKTFTEAIQKIKEQPVTVSTSKNKVFATYDVQQDTSIFFTIPYDKGWSAYQDGKKIEIKQAQTGFMKVDIPKGKGTITLSFIPNGFITGAICSFTSLLLFGIYNHRRKSSKALast
1 -179.000[S] COG4485 Predicted membrane protein  ali  100  1MKSFLKTYRTYFISFIIPVVIMSGVYLSQSIYWNSDNSPLLGDGFHQYVIFDVALRNILHGNSNLFYTFTSGLGLNFYALSSYYLGSFLAPLVYFFDLTNMPDAIYLTTLLKFGLIGLSTFFSLNKLFQSIPQILKLALSTSYALMSFTVSQLEIKTWLDVFILIPLIITGLHLLITEKKLLLYFTSLSILFIQNYYFGYMTVLFLIFWYLCQISWDFKTRKSSVLDFIVISFLAGMASLIMTLPTLFDLQTHGEKLTEVTKFQTESSWYLDLFAKQFIGSFDTTKYGAIPMIFVGLFPFILTILFFTLKSIKFHVKLIYVIFFAFLIASFYIEALDLFWQGMHTPNMFLHRYAWIFSTLLIYTAAEVLKRLKELKVWNFLVSLFLVVAGFLATIYLKSHYSFLTDLNILLTLEFLVVYSLLLLAVIKKFISVNLFAILISLFILVEMSLNASSQMDGIAKEWGFASRSAYSRDIPAMESFSTYIGNQFTRTEKLQTQTGNDSMKFNYNGISQFSSVRNRSSSSTLDKLGFKSSGTNLNLRYANNSILADSLFGIQYNISDSPIDKYGFKDIYQKDNLTLYENQYSLPIAVASQSVYNDVKFNEHTLDNQASFLNQLANVNFDYFSPIPYEKTEKIENTNDLISVTSSSNEDAAIQYQIEVPENSQVYLSFINLHFSNDKQKKVDILVNGEKKTFTTDNVFSFFNLGYTKEKKTFNINVSFPGNSQVSFESPTFYRLDTKTFTEAIQKIKEQPVTVSTSKNKVFATYDVQQDTSIFFTIPYDKGWSAYQDGKKIEIKQAQTGFMKVDIPKGKGTITLSFIPNGFITGAICSFTSLLLFGIYNHRRKSSKA 850
2 -42.400[S] COG5617 Predicted integral membrane protein  ali follow..  10  1....MKRKLYYLTLATISVIEYIPLYLAPSPPALQI------NGNGHLFKVHKLMTSGWKP-----WIEDWYAG-RFYPPLSYLTAGVLGKVLG-----SDTKGYAATLMLTSFLGALALHHYLKSTGRE-----PCISPLIFLLFPWHLTVSY------AIHLAPLFLLSLYWLREKRERYLIASALGISALTHYSILPLLIITGILILWDDL-----RTMTALGNGIKVLGAVIGLTSFWYVPFLFDKKWVE---------------FWNISENKALFKSFSLNPTLLKSPFGILLILLLLIFAIFAIKNLVDRKKVILAGLYLYLSLGFYSPTTWLYSFPLLSIVPPYRWFDLEALIIPLLIGESLKRVQRKSMVALVIIPFTVLAFMNVPKINPYPQDLIKICENI-------------------KEEPGDDWRIFVLTDVGEAINSYLPAICKKPTLNGWYHEGSPTKAGERRMIYILTYGGNLTPYLKAY----AVRFLITPKEINGYEMVLRIGKYKVYKG--------------------TSFFQPVSVIVMGKYYELPFDFVYIKDTKIISGQPNVVVLYIGQPSK-------------EEESMLWKFIKNGGTVIWVPETKGE---------------GIKAEIRAISNDELRSSLFNVSRFSPFSYNHRSWYAPVFSSNIVRPLISVGNYTLIGEVRIGNGTLYLAGGNLIFH-ALSYKSSYEISIIRALIGNMDKSTIVNYKLLERSDGRLVAEINSTERTLIRVSEAYYPYWKGYINGREVRLFRDYRGLMIFTFPRNGTLVIEFKDP--FLPLRRYSLVGWIILTAYLVIETGKT. 742
3 -14.900[R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation  ali follow..  9  13VKSHQKDWKIPLKVLILICIAVASVSSRLFSVIRYESIIHEFD------PWFNFASKILVEQGFYWYPLGRVAGGTLYPGLMVTSGIIFKVLHLLRINVNIRDVCVLLAPAFSGITAIATYYLARELK---SDACGLLAAAFMGIAPGYTSRSV---SYDAITLLMSTFALWIKAVKSGSSFWGACTLLYFYMV--FITNMIPLHVFVLLLMGRYTS-----KLYIAYTTYYVIGTLASMQVPFVGFQPVSTSEHMSALGVFGLLQLFAFYNYVKGLV--SSKQFQILIRFALVCLVGLATVVLFALSSTGVIAPWTGRFYSLWDTNYAKIHIPIIASV----EHQPPTWSSLFFDLQFLIWLLPVGVYLCFKELRNEHVFIIIYSVLGTYFCGVMVRLVLTLTPCVCIAAAVAISTLLDTYMGPEVEEDKVSEIYSLLSRVLVISSTAYFLIMFVYHSSWVTSNAYSSPTVVLSTVLNDGSLMYIDDFREYDWLRRNTPYDTKVMSWWDYGYQIAGMADRITLV-NTWNNTHIATVGKAMSSPEEKAYPILHDVDYILIIYG............................................................................................................................................................................................................................................................................................... 608
4 -14.800[O] KOG2292 Oligosaccharyltransferase, STT3 subunit  ali follow..  9  8LNSKVAGYSSLITFAILLIAWLAGFSSRLFAVIRFESIIHEFD------PWFNYTAYMVQNGWYNFLNWWYPLGRIVYPGLMITSGGIHWLLHVLNIPVHIRDICVFLAPIFSGLTSISTYLLTKELW---SAGAGLFAASFIAIVPGYISRSV---SYDAIFALQFTYFLWVRSVKTGSVFWSAAALSYFYMVSAWGGYVFIINLIPLHVFVLLIMGRYSPRLLTSYSTFYILGLLFSMQIPFVGFQPIRTSEHMAALGVFVLLMAVATLRHLQSVLSRNEFRKLFIVGGLLVGVGVFVAVVVLTMLGVVAPWSGR-----FYSLWDTGYAKIHIPIIASVSEHQPTTWFSFFFDLHILVCAFPVGVWYCIKQINDERVFVVLYAISAVYFAGVMVRLMLTLTPVVCMLAGVAFSGLLDVFLQEDSSKRMGTAISNLKSIVILAVLMLLMMFAVHCTWVTSNAYSSPSIVLAFHNSQDGSRNILDDFREAYYWLSQNTADDARVMSWWDYGYQIAGMANRTTLV-NTWNNSHIALVGKAMSSTEEKSYEIMLDVDYVLV.................................................................................................................................................................................................................................................................................................. 611
5 -13.200[M] COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family  ali follow..  10  1....MKSVRYLIGLFAFIACYY--------LLPISTRLLWQPDETR----YAEISREMLASGDWIVPHLL---GLRYFE-AGYWINS---IGQWLFGANNF--GVRAGVIFATLLTAALVTWFTLRLWRDKR--LALLATVIYL-SLFIVYAIGTYAVLDPFIWLVAGMCSFWLAMQAQTWLLLGITCGMGVMTKGFLALAVVLSVLPWVATQ---------KRWKDLFIYGWLAVISCVLTVLPWGLAIAQREPN-----------FWHYFFWVEHIQRFALDDAQHRAPFWYYVPVIIAGLLPGALYTGWKNRKHSATVYLLSWTIMPLLF---------FSVAKGKLPTYILSCFASLAMLMAHYALLAAKNNPLAAFGVTGIIATFVVSPWGPMNTPVWQTFESYKVFCAWSIFSLWAFFGWYTLTNVEKTWPFAALCPLGLALLVGFSIPDRVMEGKHPQFFVEMTQESLQPSRYILTDSV-------------------GVAAGLAWSLQRDDIIMYRQTGELKYGLNYPDAKGRFVSGDEFANLVLSVDRDEDINSLAIPPADAIDRQERLVLIQYR.......................................................................................................................................................................................................................................................................... 548
6 -11.800[S] COG5427 Uncharacterized membrane protein  ali follow..  8  83VEIPRKPLLEVVGVFTVAFVFLIVVRAWAGVQPAGGEQFL--D--------FGLLQALDRAGQLPPRDWFAGERVVYY-YGGQLMASIGAHLTDTAPRFAYEPALAGVYAMGCTAAYGLASTIAAGNGGESRPVGVPTAIGGFPLFAYLNGDLH-------MVSVPVLFVAVAVGVA--LWGGFPVAGAAILTVNTWSLPTVFGVAALAVALADPAPATQSVQRVLLAVGVAAVGGVLAVVIAWPFVQNVLLAGASNQHL--------------------AVLPVPSQAGALVFVHGLFLAAFGAYFVSRVATSVAGWVVAAAAAGAAVAVAVAVGPVV-----------VGITAVVLVGPVLGAAWWLRRRNAAGVECVLVAAGAGLVVLVEYVYLADAASYERFNTVF-ALWSVAGGVALAGVSERRASTGGLGAVFVVGLVVAASVYGGLAVTTHAANADDAS-GNAHPGEAAAARWLGDRRRGTRIVAAPGVDPYTWQNPAASLSGVPTVAGWAHAANYHSQAAWEQRVDDIGVVYETTDAASRAAILYDVTYVVGPVERARYEIEPVHRTPAVTIYR............................................................................................................................................................................................................................................................................ 778
7 -11.100[S] COG3463 Predicted membrane protein  ali follow..  12  1MKS--LIDKKLLVIIFIAYTFIIFKTCLVLYENFSYKSL---D--------LGIFSQSL---------YSTLNGKFMYNTVPNHFAVHFQILLLLLPVYAIMPSPVVLLLIQAIFLALSATLALLIACEELNHREAILVASLYIFN--SLLGIALFEFHPVSLAVPLFFIAY--LLKRGKMKLFYLTSVLILLTKEDSF-LGVVSLSLWKILM-----DGLNPESFRKNRGLILLSIASMMYGIIVIKVVIPHLGMGYIYESLYSEFELTRRKL----------------------LYFIVFNASFGFLTFLSSKGLVSVALPWLESMLSSRDTQTMIGFH-----------YPYMLLPLSYLVAIEGFKKSKKVAVSLIVAGILTSMATIPITFK...................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 341
8 -11.000[S] COG5305 Predicted membrane protein  ali follow..  7  51..................................................................................YFVL--VHLWMKLFPNQGELVSLLAARSFPALLGAVSILTYILGRLAFRSSLVGQLAAGMMAVSPYAVYLGQEVHYTLAMIWVIASLSCLVIATRHIQNILWVGINALGIATHYFFTLTLCAALVLIFLAWQQSTQAKTLVFFSPLWWRIYAVAAGTAVAGLVWLPSILENRYRSSLTGIGLHLINPIFQAFAAWVTMIMLLPIESSQLAVVIASGLVMLIFAIWATPILVRGFKFQLATQVFIGVVLGAIALFFILTYIFGVDITRGARYNFVYFPAVIILVGASLAVYWQTSKKAVMIIWLMGFVSAVTVI....................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 386
9 -10.800[O] COG4745 Predicted membrane-bound mannosyltransferase  ali follow..  6  1MRRSRDDSSPRVAAAVVAVTAAALLA---RLWALGWRVAHQDEARVADWTL------QYMDLGAWQYR-------IIHGPFLPHVNGVVFDVF------------DFTMRLVVAVVGGLLPLTAWLYRTRLSDVEVGALAVLLAANPVVLYYSRFMRNDLLLAGFMFTVGLFVRFLDTHRARYLYVPFALAFTTKENSLLYPLCWLGALALVTDDRMAVAGATDTSRLAGSALTAAVIVVSFYAPKPDLYRLFEQPGRAPAVLEAATIGTYHEFADLWASTSTVAHSYVAFLSHCGTVVSVAAVVGYLANRYATETPRPLVSFAFYWGVFSVL--------GYPAVVDIAAAWTAVNALVLAIPAAVGVGAVVRYGRRGA-----------------------------------------------AAGDTAAVRLAVTVLVVSAAGMGAVAAETTYAHPQSPSNPLVQYAQPGGTMQPTIDDIQ------RAATATSGLDVLYYGDSNFPWYLSQVGANATTVQTAAEVPDTPPPVVISVVSEEDDFAALLA-AADNSQYERHTYPRYLTDGHNTLVIYVDTTAVP...................................................................................................................................................................................................................................................................... 567
10 -10.500[M] COG4932 Predicted outer membrane protein  ali follow..  6 1185........................................................................................................................................................................................................................................................................................................................................................................................................................................................................EAAKVSKTNTAKTGTVMLTKKDSATNAELADATFELRNEDETLVRENLVTDDNGEISVADLAPGDLIETKAPTGYQLDATPVNFTIDFNQSEVEKLADATFELRNESDTLVRENLVTDDNGEISVADETKAPAGYQLDATPVNFTIDFNQSEAAKVSKINTAKTGTVVLTKKDSATNAELADATFELRNESDTLVRENLVTDDNGEISVADLAPGDYKLIETKAPTGYQLDATPVNFT--------------IDFNQSEAAKVTKTNKKKIGTIIVNFIDVDGNQLNDKEVHTGNVGEEYSVKAKEIVGHTLVKDKKGMYKETSQEITFVYEKKAMPITVEPTEPS--KLPSTGDEFPYTMLF------TGLFVSVAGVFFL------RKPKQ. 1620
11 -10.400[MU] KOG2515 Mannosyltransferase  ali follow..  9  1MPSKAPRKSLSVSFVWTFSILAVLRLTSASFRVIDD------D---EVYNYWEPLHYLLYGYGLQTWEYSPEYA--IRSWFYIALHAVPGFLARGLGLSRLHVFYFIRGVLAC-FSAFCETNLILAVARNFNRAVALHLTSVLFVNSGMWSASTSF--LPSSFAMNMVTLALSAQLSPPRTVKVVSFITIGAVIGWPFSAALSIPFILLELVDLKGRFRHLFCRWFKAIFVALLITGICITVQFVAWNIVKYNVLAKDGRGPDIYGTEPWWYYFANLSLQH----------NIVLWFAMACGPLVLLAAFTNWINLDSFLDLSSVISPFYIWLFIFIIQPH---------ERFMYPIYPVLCLAAAIGLDMSLKLMIQILSSINETVRSKFPVRFVV-----------LCVYAIIGCLSIARILAIQNYNAPMIIYPAI........................................................................................................................................................................................................................................................................................................................................................................................................................... 409
12 -9.310[S] COG5650 Predicted integral membrane protein  ali follow..  7  50............VLITTSLVFLAMGFLTKA--SRGTDGVVSLNWSGS-----QYTSACYNDIVPLYGGRGIDAPGFPYRYMEY---PVLGGIFQWICGTLPESGLYFIVTALALAFFWVLVIRMMVELTGNRVWDTVLVAASPLVAVHAFTNW------DTPAIA-AVIGAM--AVKRGNPLVAGVLIGAGTAFKLW---LYLLGAYLVLAVK--------NKNLKPFITMAAAAAVTWLVVNVPVMIAYPKAWNEFLRLNRERGAEWTTIYQVIDRNLPINLNDPVLLNVLSFGLFGASCVAILILGLKVQRTPRVAELAFLIVAAFLLF-----NKVWS--------PQYSLWLVPLAVLAFP----------QWKVLFPWMVTDAMVWPILMWHMLGTDNKGLPHEMLDLIVISRDAFIVVM......................................................................................................................................................................................................................................................................................................................................................................................................................................... 443
13 -9.160[S] COG4713 Predicted membrane protein  ali follow..  11  1MNKRVVKVEYIFMAFALFFGVLFAVINAPFQDP---------DEPIHFYRAYQISTNKIKYYLNLPLNKNKVAFNDFRSATIYYIPQSIGINLAKIFRASALYMMYFGRIANLICWTIIVFFSVKLIPFKKNLMAFLALMNLYQAASLSA---------DAMTNMAFLSIAL-RYAFGEEE-IVTMIIAFTLLAFSKRIYFVMCILFFIIPIKKFNSKKDYIGTFVIMLGACLMSLVTVSVISKILAIKVSAGSYTPGQMEFVLSHPITYIHILLRTFIGVFGWLDTRLPLNLYLFYGVALVLIALFEHTLIEKNKDRIIMFIVFIINVGLIMSALYVSWTAANIIEGIQGRYFIPIIPLLGCFIGVKANKSRNVYSKVVLAISTFTILTYSVLQLL..................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 447
14 -9.060[MO] KOG1771 GPI-alpha-mannosyltransferase III (GPI10/PIG-B) involved in glycosylphosphatidylinositol anchor biosynthesis  ali follow..  9  4..........WFWLAILVFRWWNALWVKTFFQP---------D---EFYQSLEVAHHFIFRYGFLTWEWTSAI-----SALHPLIFAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVSIMNAYVGVRTFSNSLETT-LTSIGFYYFSQRKKAYSSLLGFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPRFRFLYALGYGRLFGIFVLCVSLFLVNIIA--------DRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPFVLLTMDLQTAGTILCVFFPYSLI--------H---------LRFVYPISPILLTLAGKFFSSFSSWKRAARFFFLIGLGHALVITFL...................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 373
15 -9.040[O] COG4346 Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  9  174........................................................................LGKDIIALGMLIEDKPFYW-------RIPGIIEHALIVIIVTLVAYKIT---------KSYLASSIAATFAALDPLLFATGIVAM-LDIHVAF-FIALFM--FLALDRIRLSGIALGLAAATKLSGAFAFPILWFKILK------EKDLKEYLISGLVLPMVSFLIPEITWLEEFIASFSWHLSFKGEHPSEAPFWMWFVSLKPFPFHFDPDVYAVTDPILMISMIVFVFAVPYVSLRRKGLSEIFWMFWSIIAFFALQYILGGKTQFIFYATP---------LIPPGAVALGVISYEIIKWEYFERSLRIYLNYLRSIAKPLK...................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 472
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;