| | | | | | . 10 . 20 . 30 . 40 . 50 . 60 . 70 . 80 . 90 . 100 . 110 . 120 . 130 . 140 . 150 . 160 . 170 . 180 . 190 . 200 . 210 . 220 . 230 . 240 . 250 . 260 . 270 . 280 . 290 . 300 . 310 . 320 . 330 . 340 . 350 . 360 . 370 . 380 . 390 . 400 . 410 . 420 . 430 . 440 . 450 . 460 . 470 . 480 . 490 . 500 . 510 . 520 . 530 . 540 . 550 . 560 . 570 . 580 . 590 . 600 . 610 . 620 . 630 . 640 . 650 . 660 . 670 . 680 . 690 . 700 . 710 . 720 . 730 . 740 . 750 . 760 . 770 . 780 . 790 . 800 . 810 . 820 . 830 . 840 . 850 . 860 . 870 . 880 . 890 . 900 . 910 . 920 . 930 . 940 . 950 . 960 . 970 . 980 . 990 . 1000 . 1010 . 1020 . 1030 . 1040 . 1050 . 1060 . 1070 . 1080 . 1090 . 1100 . 1110 . 1120 . 1130 . 1140 . 1150 . 1160 . 1170 . 1180 . 1190 . 1200 . 1210 |
| # |
Score |
Template |
Links and tools | %id | First |
MSSKLVDAINEVAVSNKDKIELDGIKDDSFDGHLSITEATYDVDTFLKPSPALSKDWIRKLQKKWDREITYKGLYEYPETLARTQIRFQRHGLEGKIMGYKEVPELIEDLNSKNSSSFLRKPSSKNEFVRGSTSNIPFLADDSDVDAIAGEPSVKMALYGEDGLLQVPPGFSRGLSMTATSTTDNLNDEFDPEKWDTKKVKSSNRNFVTIHELNEHLKNVNSKHSEIDDLLPDKRSIVSLPPSTLNLHKQPDYAHVVDSSAPIENFQQLVPEMALDFPFELDNFQKEAIYHLEMGDSVFVAAHTSAGKTVVAEYAIALAQKHMTKAIYTSPIKALSNQKFRDFKHKFEDVGILTGDVQVNPEGSCLLMTTEILRSMLYRGADLIRDVEFVIFDEVHYVNDLERGVVWEEVIIMLPPHVTLILLSATVPNTKEFASWVGRTKKKNIYVISTLKRPVPLEHYLWVKQNMFKIVDQHGRFLMDGYKSANDALKKPDKPVIAKDNKNSARGRGAARGRGVQTNMMRGRGSAKSVERRDANTWVHLIGHLHKQNLLPVIVFVFSKKRCEEYVDTLTNRDLNNHQEKSEVHVVIEKAVARLKKEDRLLPQIGRMREMLSRGLAVHHGGLLPIIKEIVEILFQRGLVKVLFATETFAMGVNMPAKSVVFSGTQKHDGRNFRDLLPGEYTQCSGRAGRRGLDVTGTVIILSRSELPDTASLRHMIMGPSSKLISQFRLTYNMILNLLRVETLRIEDMIKRSFSENVNQTLVPQHEEKIKSFEEKLSALKKEMSDVDLKEIKSCLLSSESFKEYTKKMHFRAITTANGKRIFKDGRVIVFQQLDFTRTVGVLLGTSIRTNASDCTLEVAYLNPQNNLKRPSDLLAFADAFNDVYDNAIFDESNQFKYGLINLSGIERVCNTILRIDSGGIRDRRGGAFRKLSEQFASIKKFSDLLFEEVNWSKVRDFEFCEAFEKRNFLQNKLSGNPIISTPNFLTHFALAYQEYELESNIDNLSSYISDQNLELLPDYEQRIKVLQELGYIDAERTVLLKGRVACEINSTSELVLTELILENSLADFSCEETIALLSAFVFDEKTEVEPTISPHLQKGKEMILSVAEKVNQIQEHYQVLYFNEGNDFESQPRFGLMEVCYEWARGMSFNRITDLTDVLEGSIVRTIIRLDEVLRECRGAARVVGDSSMYTKMEECQNLIRRNIVFCPSLYM | Last |
| 1 | -214.000 | [L] COG4581 Superfamily II RNA helicase |
ali |
100 | 1 | MSSKLVDAINEVAVSNKDKIELDGIKDDSFDGHLSITEATYDVDTFLKPSPALSKDWIRKLQKKWDREITYKGLYEYPETLARTQIRFQRHGLEGKIMGYKEVPELIEDLNSKNSSSFLRKPSSKNEFVRGSTSNIPFLADDSDVDAIAGEPSVKMALYGEDGLLQVPPGFSRGLSMTATSTTDNLNDEFDPEKWDTKKVKSSNRNFVTIHELNEHLKNVNSKHSEIDDLLPDKRSIVSLPPSTLNLHKQPDYAHVVDSSAPIENFQQLVPEMALDFPFELDNFQKEAIYHLEMGDSVFVAAHTSAGKTVVAEYAIALAQKHMTKAIYTSPIKALSNQKFRDFKHKFEDVGILTGDVQVNPEGSCLLMTTEILRSMLYRGADLIRDVEFVIFDEVHYVNDLERGVVWEEVIIMLPPHVTLILLSATVPNTKEFASWVGRTKKKNIYVISTLKRPVPLEHYLWVKQNMFKIVDQHGRFLMDGYKSANDALKKPDKPVIAKDNKNSARGRGAARGRGVQTNMMRGRGSAKSVERRDANTWVHLIGHLHKQNLLPVIVFVFSKKRCEEYVDTLTNRDLNNHQEKSEVHVVIEKAVARLKKEDRLLPQIGRMREMLSRGLAVHHGGLLPIIKEIVEILFQRGLVKVLFATETFAMGVNMPAKSVVFSGTQKHDGRNFRDLLPGEYTQCSGRAGRRGLDVTGTVIILSRSELPDTASLRHMIMGPSSKLISQFRLTYNMILNLLRVETLRIEDMIKRSFSENVNQTLVPQHEEKIKSFEEKLSALKKEMSDVDLKEIKSCLLSSESFKEYTKKMHFRAITTANGKRIFKDGRVIVFQQLDFTRTVGVLLGTSIRTNASDCTLEVAYLNPQNNLKRPSDLLAFADAFNDVYDNAIFDESNQFKYGLINLSGIERVCNTILRIDSGGIRDRRGGAFRKLSEQFASIKKFSDLLFEEVNWSKVRDFEFCEAFEKRNFLQNKLSGNPIISTPNFLTHFALAYQEYELESNIDNLSSYISDQNLELLPDYEQRIKVLQELGYIDAERTVLLKGRVACEINSTSELVLTELILENSLADFSCEETIALLSAFVFDEKTEVEPTISPHLQKGKEMILSVAEKVNQIQEHYQVLYFNEGNDFESQPRFGLMEVCYEWARGMSFNRITDLTDVLEGSIVRTIIRLDEVLRECRGAARVVGDSSMYTKMEECQNLIRRNIVFCPSLYM |
1213 |
| 2 | -52.800 | [R] COG1202 Superfamily II helicase, archaea-specific |
ali follow.. |
23 | 197 | .....................................................................................................................................................................................................................................................................DEVDIPESFKNVLKLEGITLLPVQVLAIKNLLKGENLLVVSATASGKTLIGELAGIPKALEGKKMLFLVPLVALANQKYEDFKRRYSKLGLRVGMSRIKTDADIIVGTYEGV-DYLLRSGKKIGNVGTVVIDEIHMIDDEERGPRLDGLIARL-PKAQFIGLSATVGNPQELARSLG------MKLVLYDERPVDLERHLIIARN---------------------------------------------------------ESEKWRIIAKLCKAEVMRKSSKGFKG--QTIVFTYSRKRCHELASFLTG---------------------------------------KGLKAKPYHSGLPYKQRKITEMEFQAQMIDVVVTTAALGAGVDFPASQVIFESLAMGN----KWLSVREFHQMLGRAGRPLYHEKGKVYLIVEPG----KKYSAQMDETEDEVALKLPVIVEWSDEIEEDNVLAHACVFNRLSVIEEVNSLTLGANRSAKKVLEKLEELG................................................................................................................................................................................................................................................................................................................................................................................................................................................ |
629 |
| 3 | -46.400 | [R] COG1204 Superfamily II helicase |
ali follow.. |
18 | 1364 | .......................................................................................................................................................................................................................................................................................FFNKIQTQVFNSVKTNDSVFIGAPNGSGKTVCAELALLHHWSQEDTAVYIAPIQEIVDRRYEEWYGKFSDLGDLTGERSQDQVADLIFCTPSLSKR--WRSMRSIQKVDFYICDELQLLGG-FYGPLYEIVISRIEKNIRVVGLSVSVANARDLGEWLG-TSPQCIFNFSPKDRPNPLTIHLQ---------------------------------------------------------SFSITHFPSLMLAMSKPIYRSLKNFISQRK--STIVFTPDRKVAKQLAFDLVTF-SMADEDEYLFSLMENEAFNKVEDAA--------LQQSLKHGIAYISEITSSNDQNIVQYLYRHGLIKVLIASRDVIYSLKAKSNAVIVMGTQYYDGKEYIDYPISELLQMLGFTASIGSSELSQVILMTVTT--KKEYYKKFLNEP-LPMESHLAFVSEISTQTIE-SKQDAVDWLTWSY--YRRLVANPAYYGLQDITHESVSEFLSDLVETTMNDLSE................................................................................................................................................................................................................................................................................................................................................................................................................................... |
1833 |
| 4 | -30.300 | [R] COG1201 Lhr-like helicases |
ali follow.. |
17 | 1 | ................................................................................................................................................................................................................................................................MTFNNDFNSFHPKIQEALRTLGFRPTEPQERAFPHILDGKHTLLIAPTGSGKTESAVLPVFNAIRSGISALYITPLRALNRDMLSRIEVMGKLLDI-HGDTPQSERQDLLITTPETLQAMF-RLRKNMETVTHVVVDEIHELASSKRGA---ERLVEISGEFQRIGLSATVGNPWEIAKFLAGANRDFTVIEVALLKLLEFDVIS------------------------------------------------PQVSGEAEDREVMEIARTVGCEPEFASHLSLIRKIVEESQ--STLIFVNTRQSAEALAAGFRK---------------------------------------LGASIGVHHGSLSFEARVEAEEAFKAGALRGLICTSSMELGIDIGNVDRVVQ-------------QVSRLLQRVGRAGHRHEVSRGTVLSMEADDTAESMAITKAALEGVNSLDVVANQIAGMVMDFGEVGIEKIFRILRRAY........................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
434 |
| 5 | -28.600 | [A] KOG0953 Mitochondrial RNA helicase SUV3, DEAD-box superfamily |
ali follow.. |
15 | 138 | .....................................................................................................................................................................................................................................................................................................AKTVFPHLDCMDDLKKI---SDLRQPANWYSNARAITRKILLATEVYNKANERGTPCDLVTGEERKSLPANHVACTVEMT--------SVNTPYEVAVIDEIQQIRDPQRGWAWTRAFLGLIDEVHVCGEPGALDLLQKICETTG-----ETVEVRLYDRLTELT----------------------------------------------------------------------------ENTALGSLDNIVPGD----CIVCFSKHDIYTVSREIEARG---------------------------------------KEVAVIYGGLPPGTKLAQAAKFPANSCKVMVATDAIGMGLNLSIRRIIFYSLIKPSMNEIDTISVSSALQIAGRAGRFRTQWEHGYVTAFKSE--DLQTLQRILARTPEPIKQALHPTADQIELYAYHLPSSSLSNLMDIFVNLCTVDDSLYFMCNIEDFKFLAEMIQH............................................................................................................................................................................................................................................................................................................................................................................................................................................... |
504 |
| 6 | -25.000 | [R] KOG0354 DEAD-box like helicase |
ali follow.. |
12 | 2 | .................................................................................................................................................................................................................SDDSFSSDEDWDELDTQVVDKIENEYHNNTIGLNGYSVDEYFDANDSNRYRLQHELDESAAQQWVYPINVSFRDYQFNIVQKALF-ENVLVALPTGLGKTFIAAVVMMNYLRWKSYIVFMAPTKPLVTQQMEACYKITGQTAELSGHVPVTQSRNVFFVTPQTILNDIKHGICDRTRISCLVIDEAHRTGNYAYVEVVHL-LSLSNKNFRILALSATGNKLEAIQNVIDSLHISRIEIRTENS--IDISQYVQKKEVDFFPVDLSAEITDEPMLQKLNKGNYYRIQNAKDITSFTVVQAKQAFLAMSGQNFPANQKWDILNTFDALATFAYPLNLLLNHGIRPFYQKLVGHPKLEHLERIVTEYFEKEQTKDTRIMIFVESSAEEILRFLGKFYPNVRPAIFIGQSAVRKAAGMSQ--KLQNETVFQKGEVNTLIATSIGEEGLDIGEVDMII----CYDASA----SPIRMLQRMGRTGRK---RKGYIYMLLTRGKEEAKWERAKDAYRTLQDNIVSGRGLSLSEKSYRILPEKFRPVCDKRVIEIPKENEEVVVAPKKVQLRTKIKK.................................................................................................................................................................................................................................................................................................................................................................................................................................................. |
621 |
| 7 | -22.600 | [R] COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster |
ali follow.. |
18 | 78 | .....................................................................................................................................................................................................................................................................................PFPPHAHQARAFQRLDAPQPTLVATGTGSGKTLLNH--CAGASQAGVKAIIIYPMNALATDQASRFAKTIASVGLFVGDSTLRESPPDILLTNKMLDYLLMRPGDQ-GSLRYLVVDELHF-----DGAQGSDLACLVNQRFACVGTSATVGDLLDYAKTIFDQPFTDDAVIREDRYTVQLRSQLWLREHYLPVIHGQSVQLETDLDGIYRQFFEKGRSIVLAFPDNNEKAVSGAHQKLCPTCLKLNRQSSVQCGHCGHTEIHQLYGSQFNEH--KLITFSDSVQDAAHRASFFT-----ARTWPLMIRGQIASVLSEKESVEQVAHLALGVIWYQRQAGAVEHTGLLS--REVTEKSFYRG-INLLSATPTLEMGIDVDLSTVLLCSVPP---------AQANYLQRIGRAGRKD--GNALNITVAEGNPHD---------------QFFFEEPLEMMQGQVQAPFLNATAILERQLAAFCMDNWVKTGVPESA.......................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
1131 |
| 8 | -22.100 | [A] KOG0347 RNA helicase |
ali follow.. |
12 | 105 | .................................................................................................................................................................................EMIEGEEAEEDGEGRDDEDDEDDEETRKKKEKKAKRNKEKKKEKKKKKQKKINEAAKNQDASAAVSCDGDDTVEEQVEEEEIPPEFSAWSSMLMKSIYRLDFK-TKIQKACFVAAYQGKDVIGAAETGSGKTLA--FGLPIAADGYLRALIITPTRELALQVTEHLENAAKNLSVIVGGMFSEKQPEIVVATPGRLWELMSAGEK-LHSLSFFVLDEADRMVER--GHF-QSILDLLPVT-QTFVFSATIALSSDFRKKLKRGSSKSKQSSSGEVNSI-------------EVLSERAGMRDNVAIIDLTTTSILAPKIEES---------------------------------EEKEKDAYLYYILSVHGQGRTIVFCTSVTDLRHISGLLKILGLDVCT----------------------------------------FSEMKQRARLKSIDRFRASENGILIATDLVARGIDIKNVRTIIH----YK-------SAEVYVHRCGRTARAF--ADGCSIALIEPN--ETSKFYTLCKSFSMESVKIFPLDNSY-MPAVRKRLYLARQIYEIERKGSRENADRTWLKKHAESMELELDD.................................................................................................................................................................................................................................................................................................................................................................................................................................................. |
680 |
| 9 | -21.900 | [A] KOG0338 ATP-dependent RNA helicase |
ali follow.. |
14 | 56 | .........................................................................................................SGDEEEEGPIVLGRRQKALGKNRSADFNPDFVFTEKEGTYDGSWALADVMSQLKKKRAATTLDEKIEKVRKKRKTEDKEAKSGKLEKEKEAKEGSEPKEQEDLQENDEEGSEDEASETDYSSADENILTKADTLKVKDRKKKKKKGQEAGGFFEDASQYDLSRPLLKAITAMGFK-TPIQKACIPVGLLGKDICACAATGTGKT--AAFALPVLERPVTRVLVLVPTRELGIQVHSVTRQLAQFCNIAVGGLDVKSQPDILIATPGRLIDHLHNCPSFLSSIEVLILDEADRMLDE--YFE-KEIIRMCSHHRQTMLFSATMTDE------VKDLASVSL------KNPVRIF--------------NSNTDVAPFLRQEFIRIRPNREGDREA-----------------------------------------VAALLTRTFTDHVMLFTQTKKQAHRMHILLGLMGLQVGE----------------------------------------HGNLSQTQRLEALRRFKDEQIDILVATDVAARGLDIEGVKTVIN----FT-------TIKHYVHRVGRTARAG--RAGRSVSLVGED--ERKMLKEIVKAAKAPVKARILPQDVILKFRDKIEKMEKD--VYAVLQLEAEEKEMQQSEAQINTAKRLLEKGKEA.............................................................................................................................................................................................................................................................................................................................................................................................................................................. |
643 |
| 10 | -20.800 | [R] COG1203 Predicted helicases |
ali follow.. |
16 | 2 | ............................................................................................................................................................................................................................................................................VIKAFRKLTGHSPYEYQKEAMDNLLEGKSLIIRAPTGAGKTEASLIPFIYGLNDYPQLIYSLPTRTLVESIGERAIKYASRVAIHHGKKATSSEEDIIVTTIDTAGAYLSVPLSMPKRWALTVFDEVHTL-DPEKGLQTAAAIAMQSAKLPSIIMSATLPDVFI------------------------VKERIEKNGGKVEIMDVKNESEIKSRRNRKVELINRPDEMLTAD---------------------------------------TVLKEAENCRKLVVVV--------------------NTVERAQNL--------------------YLDLRKKIDYPIFLLHSRYLEKDRAEKEKSFEKVFGKIFISTQVIEVGMDISS-PIILSEVAPIDA----------LIQRAGRCARWGGNGEFHVFGLARDSSNPYAPYLKELIESTITEIRSKGLDWQTELQLVNNSSHFEFFMDSKFFYQRLGELARAVYEGSKAKVEQNVREIFSCDI............................................................................................................................................................................................................................................................................................................................................................................................................................................ |
437 |
| 11 | -20.700 | [A] KOG0343 RNA Helicase |
ali follow.. |
15 | 2 | ...........................................................................................................................................................................................................................AKKNRLNTTQRKTLRQKEDEYIENLKTKIDEYDPKITKAKFFKDLPISDPTLKGLRESSFILTEIQADSIPVSLQGHDVLAAAKTGSGKTLA--FLVPVTEFDGLGALIISPTRELAMQIYEVLTK---SAGLVIGGKDVKFEINILIGTPGRILQHLDQAVGLTSNLQMLVLDEADRCLDMGFKKTLDAIVSTLSPSRQTLLFSATQSQ--SVADLARLSLTDYKTVGTHDVMDGSVNKEASTPETLYIEVPLADKLD--------------------------------------------------------------LFSFIKSHLKCKMIVFLSSSKQVHFVYETFRK---------------------------------------MQPGISL-HGRQKQRARTETLDKFNRAQQVCLFATDVVARGIDFPAVDWVV----QVD-------DVDTYIHRVGRCARYG--KKGKSLIMLTPQ--EQEAFLKRLNARKIEPGQSKKKSIKPQLQSLLFKDPELKYLGQKAFISYVRSIYVQKDKQVFKFDELPTEEFAYS.............................................................................................................................................................................................................................................................................................................................................................................................................................................. |
480 |
| 12 | -20.600 | [L] COG1111 ERCC4-like helicases |
ali follow.. |
17 | 14 | .....................................................................................................................................................................................................................................................................................KIEARTYQQLLAADVIRKGNSMIVAPTALGKTVVAVLVAAERLRRGSKVLILSPSKPLAIQHEESFREFMLTCTSLTGSIKPEIKSQIISATPQTVESDILAGRYDLRDVSLIVFDECHRAVGSYSYVFLASNYIQNARHPLILGLTAS-ADEDKIKTVCENLFMNEVVVKTEGD--PDVRPYLKPIKIEWVKVRMTPELEDELLRKVLKNRLKMLKNLGVIDTISVGKKDLLKARGRVQNRIARSTSPPRACYRASCINVEHALELLETQGIRPLHQYLLLADPDFTRAMHLTRRAMMSGVEHPKLDRLMEILKRELKGDEARIIVFTQFRDTLEQNSRSGEKGLTQ--KQQRDIIFRMGNHDVLLSTSVAEEGIDIPSVDLVV----MYEPVP----SEIRMIQRRGRTGRK---RKGRMVVLITEKTRDEAYYYS-SIRKERSMKENLRGGSVNVEVNPIMEPSGEGPFIYADSRE......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
526 |
| 13 | -20.300 | [A] KOG0335 ATP-dependent RNA helicase |
ali follow.. |
17 | 294 | ........................................................................................................................................................................................................................................................................NLCQTLNNNIAKAGYT-TPVQKYSIPIILAGRDLMACAQTGSGKT--AAFLLPILAHQEPECIIVAPTRELVNQIYLEARKIYGGTQLGHSIRQIVQGCNILCATPGRLMDIIGKEKIGLKQIKYLVLDEADRMLDM--G--FGPEMKKLISCPGMLMFSATFPEEIQ------------------------LAAEFLKSNYLFVAVGQVGG-ACRDVQQTVLQVGQFSKRE-------------------------------------------KLVEILRNIGDERTMVFVETKKKADFIATFLCQEKISTTS----------------------------------------HGDREQREREQALGDFRFGKCPVLVATSVAARGLDIENVQHVIN----FDLPSTID----EYVHRIGRTGRCGNTGRAISFFDLESDNHLAQPLVKVLTDAQQDVPAWLE.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
672 |
| 14 | -20.100 | [KL] KOG1123 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 3`-5` helicase subunit SSL2 |
ali follow.. |
11 | 323 | ...............................................................................................................................................................................................................................................................................NIDLKPAAVLRPYQEKSLRKMGRARSGVIVLPCGAGKSLVGVTACC---TVRKRALVLCNSGVSVEQWKQQFKMWSTMICRFTSEAKKPMGCGILVTTYSMITHTQKRSWEA-QEWGIMVLDEVHTIP----AKMFRRVLTIVQSHCKL--LTATLLREDDKIADLNFLIGPKLYEANWLE------------------LQKKGYIARVQCAEVWCPMSPEFYREYLTTKTSKKMLL--------------------VMNPSKFRSCQFLIKYHEQRG--KTIVFSDNVFALKHYAIKMNKPFIYGPTSQNE--------------------------------------------IQILQNFKFNSKVNTIFVSKVADTSFDLPEANVLIQISSHGGSR-------RQEAQRLGRILRAKKGAIAEEYNAFFYTLVSQDTMEMSYSRKRQRFLVNQGYSYKVI-DLMYGTQEEQGQLLQLVLSASDLDCEDEKLPGEPGYRPSGSGGAVRRVGGLSSMSGGDDAIYYEHRKKNIGSVHPLFKK.............................................................................................................................................................................................................................................................................................................................................................................................................. |
795 |
| 15 | -19.500 | [A] KOG0350 DEAD-box ATP-dependent RNA helicase |
ali follow.. |
14 | 7 | ...............................................................................................................................................KSSHSKPKIEKKSKRNKRKWLNDENKTHVTASEAAIERLKKSASFSQAAQQALKQSRKEDNERDIEMQDVDAEAQPHDLLPIPQPSVEDFVDSKPHVKNITSVLPKWLAEPITVDPNTTVENISSKLVERLQKQNIT--AVQAAVLPLLSYGGDVCVSAATGSGKTLS--YVIPIVQCPRLRCVVIVPTRELTVQVAKTFEYYMSGAGLWTGQKSLRHEIDVLVSTPGRLVDHIRNDESFLQHLRYMVIDEA----DRLLDQSFQDWVDTVMMEISHPKCLQNKSNILDLDQNISPTFLPDIDTLLPYRLPSPLQKLVFSAT------------LTRDPSKIASLKLHNPRLVLVQNKDMEVDDGGEIEDDAIVFSVPPTLQEYHVSVSSEKPIL--LYHLIHSKNLTNILCFVKSNEAAARLHRLLELIH-----------------------------------ESLNQSFSC-TSSLSRDERKKIISRFATGDLNLLVCSDLMARGIDVANTQNVIN----YD-------SVRSYVHRIGRTARAG--REGFAWTLVQSH--EGHHFSKLVK-EFSHISEEFVVAYDKALEALRVEVFNSRYPQQKSF........................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
602 |
| 16 | -19.300 | [LK] COG1197 Transcription-repair coupling factor (superfamily II helicase) |
ali follow.. |
17 | 576 | .............................................................................................................................................................................................................................................................QREAKKGFAFKYDREEFQQFSATFPFEETYDQEMAINAVISDMC-LVCGDVGFGKTEVAMRAAFLAVMNHKQVAVLVPTTLLAQQHYENFKDRFANLNLAEGKVDI------LIGTHKLIQSDV-----KFNDLGLLIIDEEHRF-----GVGQKEKIKQLRANIDILTLTATIPRTLNMA--MNGIRDLSIISTPPARR-LSIKTFVRQNDD-------------------------------------------------------------------------LVVREAILREI---VYYLHNDASIENTAEKLTAL----------------------------VPEAR---------VIVGHGQMRERELERVMSDFYHQRYNVLVCSTIIETGIDVPANTIIIERADHFG---------AQLHQLRGRVGRSHHQAYAYLLTPPPKMMTKDAERRLDALENLDNLGAGFILATHDL-ELLGNEQS---ELLDAAVKALKEGREPSLEELTQQQADIEL-RVPALLPDDYLGDVNMRLSFYKRIAAAESK..................................................................................................................................................................................................................................................................................................................................................................................................................... |
1038 |
| 17 | -19.200 | [A] KOG0337 ATP-dependent RNA helicase |
ali follow.. |
14 | 8 | ...........................................................................................................................................................................LHELRRQNEDLRRRADSFQREKEEMLRRIDRLEQMVLVQESEADLDFGEDRKKQADEIPGFPSLDNDAGTSDRGADILKSKSKKNKSGGFQSMGLGFELIKGITKRGYK-TPIQRKTIPLILEGRDVVAMAKTGSGKT--ACFLIPLEPTKGARALILSPTRELAVQTYKFIKELGRFMELVLGGDSMDSQPDVIVATPGRFLHLCVEMDLKLNSIEYVVFDEADRLFEM--GFG-NETLHRLPSSRQTVMFSATLPK--LLVEFARAGLNDPVLIRLDVESKLPLALKFLY------------------------------------------------------------------RPDDRYTALVVLLKYVIPVQ---TVVFAGTQHHVELISYILTEAGISNAS----------------------------------------YSSLDPAARKINTAKFVNKKVSVLIVTDVAARGIDIPSLDFVVN----LH-------KPKLFVHRVGRCARAG--RTGTAYSIVSTD--DTAHLLDLHLFLNRPFNIHDSSALGTIPQ-------DLLEEEHLTVTDIKKSHHIAGVLRTSENAYKKYLSSR................................................................................................................................................................................................................................................................................................................................................................................................................................................ |
510 |
| 18 | -19.200 | [A] KOG0348 ATP-dependent RNA helicase |
ali follow.. |
16 | 38 | ..........................................................................................................................................................................................................................................................................TKLSDQLKERMGFEPTLVQAQAIPVILSGRDVLVNAPTGTGKTIA--YLAPLDRSHGTFALVIVPTRELCLQVYETLEKLLHVPGYVMGGEKLRKGISILIATPGRLLDHLKNTASFHKNLRWVIFDEADSILELGYGKEIEQIIKLLGSG-QNLLLSATLNDK------VNDLAKLSL------DDPVMI------------------GLDNTKLQQNLSIESPAAPDSDAEDMVIHVNKSANPLSEDYGIPSQLVQRYLRVPCGARLVALLSVLNLFEREASQKVVVFFSTRDAVDFHYSLLSEFQWPPNSETEEEGT-----------------------KELFLKCKTFHGSMEQEDRRSAFGTFKTEKQAVLLSTDVAARGLDFPKVRCII----QYD-------EATEYVHRVGRTARIG--EKGEALLFLQPI--EIDYLKELK-------KHGASLTEYPLMKVLDKFPIPGNMPRIKKVLSLESHPWVISLQRALESLTYAEPKMKSLAKNAFVSWVRGYAAHKGELKSI........................................................................................................................................................................................................................................................................................................................................................................................................................ |
546 |
| 19 | -19.100 | [LK] COG1200 RecG-like helicase |
ali follow.. |
19 | 255 | ..........................................................................................................................................................................................................................................................................TDLKQRFLATLPFQPTNAQKRVVSDIEQDLI-LVQGDVGSGKTLVAALAALTAIDNGKQVALMAPTEILAEQHANNFRRWFKEVGWLAGKVK-TGAVQMVVGTHALFQEEV-----EFSDLALVIIDEQHRFGVHQRLMLREK---FYPH---QLIMTAT---------------------------PIPRTLAMTVYADL-----------------------------------------------------------------------TSIIDEL-PPGRTPITTVVVSEERRAEIVMRVKNACVNEKRQAYWVCTLIDES------EVLEAQAAEAIWEDLTK-IGLVHGRMKPQEKQDVMMRFKNAELDLLVATTVIEVGVDVPASLMIIENAERLG---------SQLHQLRGRVGR---CTASFCVLMYKPPLGKVSQKRLQVLRDS---QDGFVIS---------------KDLEIRGPGEVLGTKQTGIAELRVANLMRDRKMIPTV.............................................................................................................................................................................................................................................................................................................................................................................................................................................. |
661 |
| 20 | -19.000 | [KL] COG1061 DNA or RNA helicases of superfamily II |
ali follow.. |
16 | 70 | ...............................................................................................................................................................................................................................................................................DLVPSLEMEPYPHQSEALAAWKLAGR-VVVLPTAAGKTYLAQLAMQ---ATPRTTLIVVPTLDLMHQWYAHLVAAFPDVGLLGGG---SRDKSPVLVAT--YDSAAIHAEALGNQYALIVFDECHHLP----TDFSKVIAEYAIAPYRL--LSATPERTDGKHADLNILIGQEVYRKRAED----LAGKALAEHEIVQIKVKLSQQERERYNNLIQIRNDRQSKVSLGSIQGWQMFVQMSARSQSGRRAMLAHREAKEIALGTDSKLRILANLLAKHYPERVLIFTADNATVYKISQDLLIPAITHQTPVKERHEILTK--------------------------------------------FREGEYNTLVASHVLNEGVDVPAAIAIILSGTG---------STREYIQRLGRILRKGNIQNKQAILY-RGEDKKANLQVVYGSGKGTTAKAAEQIEINYVVDNSSANNQGNATNGTPQPSPKRRRNNTKKTED............................................................................................................................................................................................................................................................................................................................................................................................................................................................. |
517 |
| 21 | -18.900 | [L] COG0514 Superfamily II DNA helicase |
ali follow.. |
18 | 33 | ......................................................................................................................................................................................................................................................................................FGYQQFQQEVIEAALAGRDSLVIMPTGGGKSLC--YQIPALVLEGVTLV-ISPLISLMKDQVDQLKANGVAAECVNSTLAREELIAIYNRMHAGQLKLLYVSPERVLPLAMIAVDEAHCISQ------WGHQLKQRFPNVPVMALTATADDATR-HDIMQRLQLNEPHQYLGSFDRPNIRYML----------------------------------------------------------------------VEKHKPVSQVIRYLETQRGQCGIIYCGSRKKVEMLTEKLCG-----------------------------------------NHIRAYHAGMDADERAWVQEAFQRDDLQIVVATVAFGMGINKPVRFVVHFDIPR---------NIESYYQETGRAGRDGLPAEAMMLY----DPADMNWLRRMLDEKPDGAQKQVESHLTAMGAFAEAQTCRRQVLLN--FGE......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
403 |
| 22 | -18.900 | [A] KOG0342 ATP-dependent RNA helicase pitchoune |
ali follow.. |
17 | 1 | ..........................................................................................................................................................................MAKSELKRKKHQSGNEEVKEKRQKPLKNDKKIAEELPQDEDDYEQEEENEDADQNTSVESESEELDNENEDERVQKSVNLNASSTSDIEKFSDLQLSENIQKAIKEMGFEMTEIQKRSIPPLLAGRDVLGAAKTGSGKTLA--FLIPTKPRNGTGVIIISPTRELALQIFGVAKE---TFGIVIGGANRRAEANLLVATPGRLLDHLQNTKGFFRNLRSLVIDEADRILEIGFEDEMRQIMKILPSE-QTLLFSATQTTVEDLAR---SLKPGPLYVNVDSGKPTSTVEGL---EQGYVVVDSDKRFL--------------------------------------------------------------LFSFLKRNLKKKVIVFMSSCASVKYMAELLNYIDLPVLD----------------------------------------HGKQKQQRRTNTFFEFCNAEKGILLCTNVAARGLDIPAVDWIV----QYD-------DPRDYIHRVGRTARGT-KGTGKSLMFLAPS--ELGFLRYLKTAKVSEFPANKVANVQSQLEKLVSKNYYLQQSAKDGYRSYLQAYASYSLKSIFDINKLDLAKVAKS.............................................................................................................................................................................................................................................................................................................................................................................................................................................. |
523 |
| 23 | -18.800 | [V] COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases |
ali follow.. |
12 | 449 | ..........................................................................................................................................................................................................................................................................NQWFADNPGMSELGLRYYQEDAVRAVEKAQEILLAMATGTGKTRTAIAMMFRLIQSQKRILFLVDRRSLGEQALGAFEDTRINIKGLTDK-FPEDSTKIHVATVQSLVKRTLQSDEPMARYDCIVVDEAHELQFRSQLDYYRRILDHFDA---KIALTAT-PALHTVQIF-------------------PVYRYTYRTAQIITRNAQEGVYLSKGEQVERISPQGEVINDTLEDDQDFEVAD----------------NRGLVIPAFNRAVCNELTNYLDPTGSQKTLVFCVTNAHADMVVEELRAAFKKKYPQLE------HDAIIKITGDADKDAR-----------------------QTMITRFNKERLPNIVVTVDLLTTGVDIPSCNIVFLRKVR---------SRILYEQMKGR-ATRLCPEVNKTSFKIFDCVDIYSTLESVDTMRPVVVRPKVELQ-TLVNEITDSETYKITEADGRSFAEHSHEQLVAKLQRIIGLATFNRDRSET............................................................................................................................................................................................................................................................................................................................................................................................................................................... |
937 |
| 24 | -18.700 | [A] KOG0333 U5 snRNP-like RNA helicase subunit |
ali follow.. |
17 | 307 | ........................................................................................................................................................................................................................................................................GFPDEVYQAVKEIGYL-TPIQRQAIPIGLQNRDVIGVAETGSGKTAA--FLLPLLVDLGPYAIIMAPTRELAQQIEEETNKFGKLLGIVIGGASREDQVEVVIATPGRLLDVLENRYLLLNQCTYVILDEADRMLDMGFEPDVQKVLEYMPDT-QTVMFTATMS--------------SAIERLARQYLRRPAVVHIGSAGKPTERVEQVVYMVPEDRKRK------------------------------------------------------KLVEVLESQFQPPIIIFVNQKKGADMLSKGLTKLGFKPTV----------------------------------------HGGKGQDQREYALQALKEGTSDILVATDVAGRGIDVKDVSLVLN----YDMAKSIE----DYTHRIGRTGRAGKHGKAITFLTPDDTAVYFDLKQVLVESPVSSCPPELA.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
705 |
| 25 | -18.400 | [L] COG4098 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) |
ali follow.. |
17 | 86 | ...............................................................................................................................................................................................................................................................................QDVLKWRGQLTPFQEKVSEGLDKQKPTLVHAVTGAGKTEMIYQVVAKVINAGGAVCLASPRIDVCLELYKRLQQDFSGIALLHGESEPYFRTPLVVATTQLLKFY--------QAFDLLIVDEVDAFPYVDNPMLYHAVKNSVKENGLRIFLTATSTN-----ELDKKVRLGELKRLNLPRRPLIIPKPIWLSD------------------------------------------------------------NRYLDKNRLSPKLKSYIEKQRKTA--PLLIFASEIKKGEQLAEILQEQ-------------FPNEKIGFVSSVTED--------------------------RLEQVQAFRDGELTILISTTILERGVTFPCVDVFV-------EANHRLFTKSSLIQIGGRVGRSMDRPTGDLLFFHDGLNASIKKAIKEIQ............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
424 |
| 26 | -18.400 | [A] KOG0336 ATP-dependent RNA helicase |
ali follow.. |
13 | 61 | ..............................................................................................GVVIGYSGSKIKDLQHSTNTKIQIINGESEAKVRIFGNREMKAKAKAAIETLIRKQESYNSESSVDNAASQTPIGRNLGRNDIVGEAEPLSNWDRIRAAVVECEKRKWADLPPVKKNFYIESKATSCMSEMQVINWRKENFNITCDDLKSGEKRL----PKPTCRFKDAFQQYPDLLKSIIRVGIV-TPIQSQAWPIILQGIDLIVVAQTGTGKTLLDSQPISREQRNGPGMLVLTPTRELALHVEAE-CSKYSYKGLIYGGRDISKGVDIIIATPGRLNDLQMNNSVNLRSITYLVIDEADKMLDMEFEPQIRKILLDVRPDRQTVMTSATWP--------------DTVRQLALS----------YLKDPMIVYVGNLNLVAVNTVKQNIIVTTEKEKRAL----------------------------------------TQEFVENMSPNDK--VIMFVSQKHIADDLSSDFNIQGISAES----------------------------------------HGNSEQSDQERAVEDFKSGNIKILITTDIVSRGLDLNDVTHVYN----YDFPRNID----VYVHRVGYIGRTG--KTGTSVLITQRDSKMAGELIKILDRANQSVPEDLV.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
598 |
| 27 | -18.400 | [A] KOG0331 ATP-dependent RNA helicase |
ali follow.. |
16 | 100 | ........................................................................................................................................................................................................................................................................NFPANVMDVIARQNFT-TAIQAQGWPVALSGLDMVGVAQTGSGKTLS--YLLFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLIYGGADLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWP--------------KEVRQLAED----------FLKDYIHINIGALELSANHNILQIVDVCHDVEKDEK----------------------------------------LIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMG----------------------------------------HGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVIN----YDYPNSSE----DYIHRIGRTARST--KTGTAYFFTPNNIKQVSDLISVLREANQAINPKLL.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
472 |
| 28 | -18.100 | [A] KOG0345 ATP-dependent RNA helicase |
ali follow.. |
17 | 22 | ........................................................................................................................................................................................................................................................................PLSGDIIEALNQSDFECTPVQAATIPLLCSYKDVAVDAATGSGKTLA--FVVPLPKPHQVMGVIISPTRELSTQIYNVAQPFVSNSVLLVGGREVKADCNVLIGTPGRLSDIMERMEILFRNLEILILDEADRLLEMGFQRQVNYIISRLPKQRRTGLFSATQTEG------VEELAKAGL------RNPVRVE----------------------------------------------RAKSKSESSQQLTNSKTPSGLHLEYMECEADKKSSQLVDLLIKNSDKKLIVFFMTCASVDYWGLVLSKIPALKSISLIPI-----------------------------------HGDMKQNARDKALASFTKASSGALLCTDVAARGLDIPGIDYVV----QYD-------DPNMFNHRAGRTARLG--RQGRAIVFLLPK--EEAYVEFMRIRRVPLEERKCSEDASDVIPIIRSAAMKDRAVMEKAFVSFVRAYKEHHCSFIFRWKDLEIGKLAMG.............................................................................................................................................................................................................................................................................................................................................................................................................................................. |
463 |
| 29 | -17.900 | [A] KOG0332 ATP-dependent RNA helicase |
ali follow.. |
14 | 130 | ...................................................................................................................................................................................PRPRDTPPQYGGHQAAQQFVKPDSKYKFTKPATEEAHEQVPVPADIALLNKFIQKEVKMMKDVVVDVQRQDPKSPLYSISSFRELRLKPEVLKALDTMNFQ-TRIQETALPLLEPPSNLIAQAQSGTGKT--AAFVLTMLCRMCPQCICLAPTLELAKQKMGKFIDNLKIHYAIKGGNGRKLTEQIVIGTPGITRDYLQKYKCIPSKIRCLVLDEADVMIYTDISTTIYNMVEDASDSVQSMLFSATYDE--PVINFATKIIKNAIVVMLKREEQA-IKQFYVQ--------------------------------------------------------------------ACRDSKYAAIVNLYSGLAVASSVIFCHTKASVMWLYENMRARGHQVDV----------------------------------------HGDMTVVERADTIIHFKRGDFKVLITTNVFARGIDVAQVSVVINEGTPMVVDGFTQPDCETYLHRIGRTGRFGKTGIAINLIDSEDSMNMINVLENHFQMKIARMD........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ |
600 |
| 30 | -17.900 | [A] KOG0340 ATP-dependent RNA helicase |
ali follow.. |
15 | 2 | ..........................................................................................................................................................................................................EEPTPEEEGGITIMSKSRKNPKTVVNIQSQKLDSDQNTPQFEKFTNPNPSSDTTSATNFEGLGLAEWAVETCKELGMR-TPVQTHCVPKILAGRDVLGLAQTGSGKT--AAFALPILHRYGVFALVVTPTRELAFQLAEQFKALGSCLNLIVGGMDMLTQTHIVITTPGRIKVLLENNPDVFSRTKFLVLDEADRVLDVGFQDELRTIFQCLPKSRQTLLFSATMT--------------SNLQALLEHSSNKAYFYEAYEGLKTVDTLTQQFIFEDKDAKELY---------------------------------------------------LVHILSQMEDKGIRSAMIFVSTCRTCQRLSLMLDELEVENIA----------------------------------------HSLNSQSMRLSALSKFKSGKVPILLATDVASRGLDIPTVDLVIN----YD-------DPRDYVHRVGRTARAG--RGGLAVSIITET--DVKLIHKIEEEVGKKMEP....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
427 |
| 31 | -17.800 | [A] KOG0326 ATP-dependent RNA helicase |
ali follow.. |
14 | 1 | ..............................................................................................................................................................................MGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQSMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWE-SPIQEESIPIALSGRDILARAKNGTGKS--GAYLIPLLERDNIQAMVIVPTRELALQICIQVSKHMGGAKVMAGGTNLRDDVHVVIATPGRILDLIKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPL--SVQKFMNSHLQKPYEINLMEELTLKVTQYYAY---------------------------------------------------------------------TERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFY----------------------------------------HAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVIN----FD-------LAETYLHRIGRSGRFG--HLGLAILITYDDRFNLKSIEEQLGTEIKPIPSN...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
452 |
| 32 | -17.400 | [L] COG1198 Primosomal protein N` (replication factor Y) - superfamily II helicase |
ali follow.. |
17 | 259 | .....................................................................................................................................................................................................................................................................................PLELNPEQRQARDAVVSSPPFLLQGITGSGKTEVYLQIIQGALDKGKTAILLVPEISLTPQMTERFIARFGDVAILHSGLS-RGDAQVVVGA----RSAIFA----LKNLGVMIIDEEHYKQDSNRYHAREVAILRAQYNQATLVLGSATPSLESRA----RAGKGVYQHLRLTQRTIP-----------VQVIDFRDYIGQNETSNFTPPLLEAIQDRLVKKE--------------------------------------QVVLMLNRRGYSSFVMTVDTCPNCD--------ISLTLHMDTKTMNCHYCGFSKDIPQVCPNCKS----RSIRYYGTGTQKAELFPQARQALLDQFGRGEADILLGTQMIAKGLDFPNVTLV---LNADTALNLPDFRSSELTQVAGRSGRA--EKAGQVLI--QSYNPQHYAIRFAKDQDAYEMGIRRQLGYPPYYFTIGITLSHKKEEEVFKRAYEVMNILRSGLSETSPIL........................................................................................................................................................................................................................................................................................................................................................................................................................................................ |
739 |
| 33 | -17.200 | [LKJ] COG0513 Superfamily II DNA and RNA helicases |
ali follow.. |
20 | 8 | ........................................................................................................................................................................................................................................................................GLSPKVIAAVEAAGYT-TPIQAGAIPPALERKDVLGIAQTGTGKT--ASFVLPMARARMPRTLILEPTRELAAQVEENFVKYGINHRLLIGGVSFEEQADVLIATPGRMLDHFERGKLLLTGVEILVIDEADRMLDM--GFI-ERICKLIPFTRQTLFFSATMP--------------PEITKLTEQFLHSPVRIEVAKASSTAKTVTQRLVKSGKKDWDKRAVLRD--------------------------------------------------LIQSEGDSLKNAIIFCNRKKDVSELFRSLTRHEFDAGA----------------------------------------HGDMDQRARMAMLSSFKDGKLRLLVASDVAARGLDIPDVSHVFN----FD-------HAEDYVHRIGRTGRAG--RSGKAFTIVTSS--DTKYLAAIESMIGEKIEWH...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
373 |
| 34 | -17.200 | [A] KOG0339 ATP-dependent RNA helicase |
ali follow.. |
19 | 271 | ........................................................................................................................................................................................................................................................................SFDKLLMEAIRKSEYE-TPIQAMAIPSALSGRDVLGIAKTGSGKTAA--YLWDLKAGEGPVAVIVVPTRELAIQVFQEAKKFCKVYNIAYGGGSKWEQAEMVVCTPGRIIDLVKMGATNFLRTTFLVFDEADRMFDM--G--FEAQVKSISDHVQCLMFSATFK--------------QKVERLARDALVDPVR-----------IVQGEVGEANADIEQKVFVMQNQDVK------------------------------------------LHWLIRNLVEFA--KVLIFVTKKLDSEDVAKKLKMKDFDIVL----------------------------------------HGDMLQAERNENLLKFRKK-SQILVATDVAARGLDISEIRTVIN----FDMARDID----THVHRIGRTGRAG--HKGTAYLVTEKDIEMVGHLVKNLESVSQEVPKPLM.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
641 |
| 35 | -16.800 | [A] KOG0330 ATP-dependent RNA helicase |
ali follow.. |
17 | 2 | ......................................................................................................................................................................................................................APSEKKLTEDKKNSSLNKKIETSNSSSEKSSENNNGDSQNNEAPKTFKELGVIDELCEACEKLGFK-TPIQQEAIPVVLNKRDVIGLAQTGSGKT--AAFALPVIQESPFFAVVLAPTRELAYQISEQFEAIGGSIGVIVGGMDMVTQPHVLVCTPGRLMDHLENTKGFLKNLKYLIMDEADRLLDMDFGPIIDKILKIIPHERRTLLFSATMT--------------SKVEKLQRASLHQPVRVAVSSKFSTVDTLIQRYLFFPFKHKDTY------------------------------------------------------LVYLVNELAGNSIIIFARTVNDTQRLAILLRTLGFSAIP----------------------------------------HGQLSQSNRLGALNKFKSGARSTLVATDVAARGLDIPLVDVVIN----YD-------DSKAYIHRVGRTARAG--RAGKSIALVTQY--DLEPFLRIEATIGKKMQE....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
410 |
| 36 | -16.700 | [L] COG1643 HrpA-like helicases |
ali follow.. |
12 | 52 | .............................................................................................................................................................................................................................................................KEIEQAAAQVALREAARPSITYPQNLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELQEPGGCIGSDHVSSNTMVKLMTDGILLAEI-QQDRLLMQYDTLIIDEAHERSDFLLGYL--KELLPRRPDLKVIITSATI-DPERFSRHFNNA------IIEVSGRTYPVE--------RYRPIVEEADDTERDQLQAI----------------------------------------------------FDAVDELGRESPGDILIFMSGEREIRDTADALNKLNLRHTE-------------------------------------------VLPLYARL-NRVFQSH--RIVLATNVAETSLTVPARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVS---EGICIRLYSED----DFLSRPEFTDPEILRT------NLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGA-----------------ADEQQTAYKLTPLGRQLSQLPVDPRLARMVLEAQKH--------------------------------------------------------------------------VREAMIITSALSIQDPRERPVDKQQASDEKHRRFHDKESD---------------LAFVNLWNYLGEQQKALSSNQFRRCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHVALLT-GLLSHIGMKDADKQEYTGARNARELVETSRLWGRIAARIEPEWVEPVAQHLIKRSYSEPHWERAQGAVMATEKVTVYGLPIVAARK-----------------------VNYSQIDPALCRELFIRHALVEGDW-KLRAEVEELEHKSRRRDILVDDDTLFEFYDQ---RISHDVISARHF.. |
813 |
| 37 | -16.500 | [A] KOG0341 DEAD-box protein abstrakt |
ali follow.. |
17 | 152 | ........................................................................................................................................................................................................................................................................KFPRPVLDTLKEKGIV-TPIQVQGLPVILAGRDMIGIAFTGSGKTLVEEMMMPIAAGEGPIGLIVCPSRELARQTYEVVEQCIGGIDMRSQLEVVKRGVHIVVATPGRLKDMLAKKKMSLDACRYLTLDEADRLVDLGFEDDIREVFDHFKSQRQTLLFSATMP--------------TKIQIFARSALVKPVT-----------VNVGRAGAANLDVIQEVEYVKQEAK-------------------------------------------IVYLLECLQKTS--PVLIFCENKADVDDIHEYLLLKGVEAVA----------------------------------------HGGKDQEDREYAISSFKAGKKDVLVATDVASKGLDFPDIQHVIN----YDMPAEIE----NYVHRIGRTGRCGKTGIATTFINKNQSETTLLDLKHLLQEAKQRIPPVLA.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
529 |
| 38 | -16.400 | [A] KOG0344 ATP-dependent RNA helicase |
ali follow.. |
20 | 63 | ........................................................................................................................................................................................................................................................................KINSRLLQNILDAGFQ-TPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQGFRALIISPTRELASQIHRELIKISEGTGFIHKAAKSSKKFDILVTTPNRLIYLLKQDPPGLASVEWLVVDESDKLFEDGKTGFRDQLASIFSHKVRRAMFSATFAYDVE--QWCKLNLDNVISVSIGARNSA-------VEQELLFVGSETGKLL-------------------------------------------------------------AMRELVKKGFNPPVLVFVQSIERAKELFHELIYEGINVDV----------------------------------------HAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVIN----YD-------SSVEYIHRIGRTGRAG--NKGKAIFFTEDDKPLLRSVANVIQQAGCPVPEYIK.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
435 |
| 39 | -16.300 | [A] KOG0329 ATP-dependent RNA helicase |
ali follow.. |
15 | 2 | .......................................................................................................................................................................................................................AENDVDNELLDYEDDEVETAAGGDGAEAPAKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFE-SEVQHECIPQAILGMDVLCQAKSGMGKT--AVFVLATLQQGQVSVLVMCHTRELAFQEYERFSKYMPNVKVAVGGLSIKKDPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQ------QEIFRMTPHEKQVMMFSATLSK--EIRPVCRKFMQDPMEIFVDDETKLTLHGL----QQYYVKLKDNEKNRK-------------------------------------------------------------LFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIA----------------------------------------HRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFN----YD-------DSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNISELPDEIDIS.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. |
421 |
| 40 | -16.100 | [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family |
ali follow.. |
15 | 693 | ...............................................................................................................................................................................................................................................................................DVPQQIQATLRSYQTEGVHWLKMHLNGILADDMGLGKTLIIAVTQSKLEKGSGCSLIVCPTSLVYNEEFRKFNPEF-RTLVIDGVPSQRRKQ--VAITS----NLLQKDVELYKSFRFVVLDEAHHIKNRTTRNA--KSVKMIQSDHRLI-LTGT-----------------------------PIENSL---EELWSLFD----FLMPGLLSSYDRFVGKYIRTGNYMGNKADN-----------------------------------MVALKKK-VSP---FILRRKDLPPVSEILYHCHLTESQKESYAASAKQELSRLVKQEGFERIHIHVLATLTRKQICCHDSAKYDMLMDLLSSLVDSGHKTVVFSQYTKMLGIDLESRGIPFVYL---DGST-NQFNEDPSLLISLKAGGTGLNLVGADTVIHYDMWWNPAV-------ENQATDRVHRIGQSRSVSSYKL----TLNTIEEKILTLQ--------NRKKSLVKKVINSDDEVVSKLTWEEVLELLQI............................................................................................................................................................................................................................................................................................................................................................................................................................... |
1166 |
| 41 | -15.900 | [A] KOG0923 mRNA splicing factor ATP-dependent RNA helicase |
ali follow.. |
18 | 252 | ......................................................................................................................................................................................................................................................................................LPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTVPQYLVEAGFTKDKKMICTQPRRVAAMSVAARVAEEMGKLGNEVGEDCTSDRTILKYMTDGTLREFL--SEPDLASYSVMIIDEAH--TDILFGLV--KDIARFRPELKLLISSATL-DAEKFSAFFD-----DAPIFRIPGRRYPVD--------IFYTKAPEADYIDACCVSVLQIHATQPLGD--------------------------------------------------------ILVF------------------LTGQDEIETCQEVLHDRVKRLGSKIRELI-------------------VIPVYANL-AKIFEPNARKVILATNIAETSLTIDAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTA---PGKCFRLYTAW----AYKHELEDNTVPEIQRI-----NLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYAL........................................................................................................................................................................................................................................................................................................................................................................................................................................................ |
652 |
| 42 | -15.900 | [A] KOG0349 Putative DEAD-box RNA helicase DDX1 |
ali follow.. |
12 | 234 | ............................................................................................................................................................................................................................................................................................KNAELKFNFGEEEFKFPPKDGFVALSKAPDGYIVKSQNAPKALIVEPSRELAEQNIKQFKKYIDNPKLIIGGVALENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQRLQVIVCSATLHSF-DVKKLSEKIMHFPTWVDLKGEDSVP--------------------------DTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQFS------------------------------CVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDE--------KQNYVHRIGRVGRAE--RMGLAISLVATE--KEKVWYHVCSSRGKGCYNT-TIWYN--MQLLS----EIEEHLNCTISQVEPDIKVPVDEFD----KVTYGQKRAAGGGSYKGHVDILAPTVQELAALEKEAQTSFLHLGYLPNQL...................................................................................................................................................................................................................................................................................................................................................................................................... |
736 |
| 43 | -15.400 | [J] KOG0327 Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases |
ali follow.. |
18 | 38 | ........................................................................................................................................................................................................................................................................NLSESLLRGIYAYGFE-SAIQQRAILPCIKGYDVIAQAQSGTGKT--ATFAISILQQKATQALVLAPTRELAQQIQKVVMALGDYMGACIGGTNVRAEPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPS--DVLEVTKKFMRDPIRILVKKEELT-IRQFYIN--------------------------------------------------------------------EREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSA----------------------------------------HGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVIN----YD-------NRENYIHRIGRGGRFG--RKGVAINMVTEE--DKRTLRDIETFYNTSIEEMPLNVADLI.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. |
406 |
| 44 | -15.200 | [J] KOG0328 Predicted ATP-dependent RNA helicase FAL1, involved in rRNA maturation, DEAD-box superfamily |
ali follow.. |
18 | 32 | ........................................................................................................................................................................................................................................................................NLKEELLRGIYAYGFE-SAIQQRSITPIVKGRDVIAQAQSGTGKT--ATFSISILQSRETQVLCLSPTRELAVQIQKVILALGDMMNVCIGGTNLGEDQHIVSGTPGRVFDMIKRRVLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPH--EILEMTSKFMTDPIRILVKRDELT-IKQFFVA--------------------------------------------------------------------EREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSS----------------------------------------HGDMPQKERDEIMKEFRAGQSRVLITTDVWARGIDVQQVSLVIN----YD-------NRELYIHRIGRSGRFG--RKGVAINFVKSD--DIRILRDIEQYYSTQIDEMPMNVADLI.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. |
399 |
| 45 | -15.200 | [A] KOG0346 RNA helicase |
ali follow.. |
13 | 20 | ........................................................................................................................................................................................................................................................................NLDPRLQRAIHKCEFE-TSVQSETIPLALEGKDLVAQARTGSGKT--AAYLIPIENQRGIFALLLVPTRELAQQVYNVLEK-ATNSSDTVQRPLLLDLPDIVIATPSRCVVHVASGVLPLDKLKFLVIDEADLMLSFGYNEDMKTLSRSLPRGTQSFLMSATLSK--NIASLQKLVCRNPFILVKDKEASGKLTQYVV---------------------------------------------------------------------KCSEQDKFLLAYILLKLRLIKILIFVNEINRCYRLKLFLEQFGLKS---------------------------------------LVLNSELPVNSRLHILEQYNKGLYQIIIATDESGMMGEIEELENNVD------VEEEVISTDQPTLDKMKDQENRGLDFENVACVL-NFDMPSNTKSYIHRIGRTARAGKP-----GTAMSFVVPKSEVGKHKPTSLESCKKDESVLRRLEKKQISLQPYSFD.................................................................................................................................................................................................................................................................................................................................................................................................................................................. |
470 |
| 46 | -15.200 | [S] COG3421 Uncharacterized protein conserved in bacteria |
ali follow.. |
10 | 1 | ..................................................................................................................................................................................................................................MNSINQQKIKRRKKMANNKTLFDWVEDRKSTLEEIEQTDFFALPEFVERNLKYPFFEWQKSALENFNRPTHLLFNMATGAGKTMMMAALILYYFEKGRHFLFFVNQNNIVDKTENNFIDPAHAKFLFTEKILQGDGIEIKFTSIQKLYNDIHTERENQTTLAVMLGDEAHHLNAEIERKGWEHMVLELLLNKNLLEFTATLPENAD---------------VQQKYADKIITKFGL------------KEFLQKGYTKEINLVSSTLNKKERVLHALLFAWYRHQIALKYGIANFKPRSKTIDESKADYSAFLNWAENVQADDF--------------EFLDTFSGSLNNSDNANEQGKTRTEQALKFMQDNKFGFAHLANWVK--HNVIITNSE------EKLLNNL-ADNPIRAIFTVDRLTEGWDVLLFDIVRLYEGQNGGGSNKKSGKTSEKQLIGR-GVR------------EGKQPNKRKFDNDMQHELRILEELFYYTHDEQSRYIS----ELKNELRKDGYLPEKDDDKVLATFKLKSEFADNKDFRE............................................................................................................................................................................................................................................................................................................................................................................................................................................... |
595 |
| 47 | -15.100 | [R] COG4889 Predicted helicase |
ali follow.. |
14 | 173 | .....................................................................................................................................................................................................................................................................................PYSPRPHQQTAIEKATHDRGKLIMA-CGTGKTFTALRLSEEVARLNARILFLVPSISLLSQTLKEWTAQKTM--AVCSDSKVSKAAE-VPVSTD-IAEKLYQSLPAVHAFDLVICDEAH--DPSNFTRIHDASYIKAAKR---LYMTAT-PRLFD-----GKAADHSAEVSSMDDEAIPEFHRLGFGEAV-------EKGLLTDYKVVVMTVDEQVAASALTVLGSTPGEELTLDMTSAIIGAWNGLAKRSGKEQD-----TKTGFSSSDAAMERAVAFARDIKTSQQIAESFPRV--------------VNAYTTELEVKNDDVDEHNLNLSV-----CQHVDGSMNA-NSRLTWL-QSMETKILTNARCLSEGVDVPADSVIFFNPRN---------SMVDVVQSVGRVMRKSPGKNYGYIILPVAVPPGVAPSAALND------SRRFKVVWQ-VLNALRAHDDRFNAMVNS............................................................................................................................................................................................................................................................................................................................................................................................................................................................................. |
654 |
| 48 | -14.600 | [KL] KOG0387 Transcription-coupled repair protein CSB/RAD26 (contains SNF2 family DNA-dependent ATPase domain) |
ali follow.. |
12 | 276 | .......................................................................................................................................................................................................................................................................................HLFRYQVTCVQWLCQEAGGIIGDEMGLGKT-IQIVSFLSSLHHSGKFLIVCPATLMKQWV-NEFHTWWAPLRVVVATGSGQRRGHILITTYAGLRI----YGDLILPREWCVLDEGHKIRNPDSEIS--ISCKQIRTVNRII-LSGT-----------------------------PIQNNL---TELWNLFD----FVFPGRLGTLPVFQNQFALPINIGGYANASNVQVQTA-------------------------YKCACMLRDL-ISP---YLLRRMKLDVAADLPKKSEQVLFCKLTPLQRKAYQDFLQGSDMQKILNGKRQMLYGIDRKICNHKSGKLKVIRALLTLWKKQGHRTLLFSQTRQMLDI-KDLPDVHYCRM---DGSALRQDLVDNFNKLTTRVGGLGVNLTGARVILFDPDWNPSTDAQ--ARERAWRLGQKKDVV---VYRLMTAGTIEEKIYHRQIFKQFLTNKILKDPKQRRFFKMTDLHDL................................................................................................................................................................................................................................................................................................................................................................................................................................................. |
791 |
| 49 | -14.500 | [A] KOG0925 mRNA splicing factor ATP-dependent RNA helicase |
ali follow.. |
15 | 75 | ......................................................................................................................................................................................................................................................................................LPVYQQREEFLKIYHENQIIVFVGETGSGKTTIPQFVLYDELPHLTNIACTQPRRVAAMSVAKRVADEMDDLGEEVGEDCSGPNTLLKYMTDGMLLREAMT-DHMLSRYSCIILDEAH--TDILMGLM--KRLATRRPDLKIIVMSATL-DAKKFQKYFF-----DAPLLAVPGRTYPVE--------IYYTQEPERDYLEAALRTVLQIHVEEGPGD--------------------------------------------------------ILVFLTGEEEIEDACRKITLEADDLVREGAAGPLKVYPLYGSLPPNQQQ------------------------IFEPTPEDTKSGYGRKVVISTNIAETSLTIDSKQKIYNPRIRVESLLVSPISKASAQQRAGRAGRTR---PGKCFRLYTEE----AFRKELIEQTYPEILRS-----NLSSTVLELKKLGIDDLVHFDYMDPPAPETMMRALEELNYL........................................................................................................................................................................................................................................................................................................................................................................................................................................................ |
483 |
| 50 | -14.300 | [KL] COG4646 DNA methylase |
ali follow.. |
15 | 488 | ......................................................................................................................................................................................................................................................................................FVLYGHQKRGIWRIISAGSTYLAHAVGAGKTMT---MAASIMEQRRLGLVAKAMQVVPGQAAREFLALYPTARILTATIGVPAAFEQQMIHDELLEALSTRKDDLLTGVDQIIVDEAQEFRKLSFATNMSTLLYVKSRFIELVLASGTITNTHEFDAWASTFGDTTTELELQPSRKYKPVSRFASFVNVPELIAMFRSFADVVMPADLREVKVPAISTGRRQIVTSKPTQAFKHYQMVLAERIKAIEEREGPPQPGDDILLSVITDGRHAAIDLRLV---ADNKLNNLISNAFNIDGKSFELTGAAQMIFSDLGTISVEKTRGFSAYRWIRDLIRLGVPASQDFKKSEAKQRLFGDVRAGSVRFLISSETMGTGVNAQLRLKALHHLD----------LPSQIEQREGRIVRQGLDATMWQNNERKARFIAAALSGDTSIRRLEDLGEGQANQFAMAKDQRLMQKAGLEADIAR--DQHAVRRQIRDAERYVESATRRIAEIGQ............................................................................................................................................................................................................................................................................................................................................................................................................................................... |
1148 |
| 51 | -14.200 | [B] KOG0389 SNF2 family DNA-dependent ATPase |
ali follow.. |
12 | 288 | .......................................................................................................................................................................................................................................................................................QLADYQIIGLNWLKQEMNGILADEMGLGKTIQVIAFLAYLKENGLS-LIVVPSSTLDN--EAEISRWCPELVVEKGSQDERTGFDVLLTTYHIVGS--PEERKMFRVCKLVIFDEAHMLKNMTTGTPLQNNLLELISLLCFVMPKFFAKSIEDIKSLFAKFQETQIQRAKRIMKPFVLRR--LKKDVLKNLPKKLSLVEKVPMSSQQKIYYHELVDYYSNNKGEVCSS--------------------------SERAGIAIMMEMRRIANHP---LLMRHYFTDANLRGFSKRLANASSFKKTNEQYIFEELAVMSDFQYQMMNKHEFYDVKIPDNLICDSGKFLYLDTLLPKLKAEGHRVLLFSQFTMMLDI-LRIRKFGFCRL---DGANVRQDLITDFNGLSTKAGGVGINTAADTCVIHDIDFNPYNDKQ--AEDRCHRMGQQRPVT---IYRLISESTIE-EGILMAAEEKLKLEKDITSNEKGEVHEQRCVVKLLTTALGLDKDQEEQLNNSLNNSIASPAK..................................................................................................................................................................................................................................................................................................................................................................................................................... |
844 |
| 52 | -13.500 | [A] KOG0922 DEAH-box RNA helicase |
ali follow.. |
13 | 2 | ..................................................................................................................................................................................................................................................AQGELKSFVQNSRPNPKSPTVSPFSMRQKIAEHRRSLPIASVEKRLVEEVQKNDILIIVGETGSGKTTLPQFLYNAGFCREGKMIITQPRRIAAVTVAKRVAEECEQLGQKVGDDTTSGSTRLKYMTDGLLLREALL-DPHLSRYSVIIVDEAH--TDVLLALL--KKIQRTRSQPVSEKTEFGN-VASQVQTTTR---DANGPQQNGVLKGYQGRK-----LSPLKLIIMSASLDARVFSEYFGGAK--------------------------HVQGRQFPVDILYTVHPESDYVDATLVTIFQEKPGDILVF------------------LTGQDEIESVERLVQERLQNIPEDKRKLL-------------------PLAIFSAL-MKVFATGFRKVILATNIAETSITIPVKARSYDPSKGMESLDVVPASKAQTLQRSGRAGREG---PGKSFRLYPER-----EFEKLEDSTKPEIKRC-----NLSNIILQLKALGIDDIVGFDFIDKPSRGAIIKALAELHSL........................................................................................................................................................................................................................................................................................................................................................................................................................................................ |
474 |
| 53 | -11.600 | [A] KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1) |
ali follow.. |
13 | 408 | .......................................................................................................................................................................................................................................................................................QLNSSQSNAVSHVLQRPLSLIQGPPGTGKTTSATIVYHLSKIHKDRILVCAP----SNVAVDHLAAKLSSVSNLALHNLVGRGAKGILNKADVVCCTCVGAGDKRTKFRTVLIDESTQASEP-------ECLIPIVKGAQVILLGPVILERKAADAGLKQSLGHVPIRLEVQYRMNPLSEF------------PSNMFYEGSLQNGVTIEQRTVPNSKFPWPIRG-----------------------------------------------IPMMF-WANYGREEISA--NGTSFLNRIEAMNCERIITKLFRDGVKPEQ--------------GVITPYEGQRAYILQYMQMNGSLD-VEV--SVDAFQ-G--REKDYIILSCVRANEQQAIGFLRDPRRLNVG-RA-KYGLVILGNPRSLARNTL---NHLLIHFREKGCLVEGTLDNLQLCTVQLVRPQPRKTERPMNAQFNVESEMGDFPKFQDFDAQSMVSFSG.................................................................................................................................................................................................................................................................................................................................................................................................................................................. |
890 |
| 54 | -11.500 | [L] COG1110 Reverse gyrase |
ali follow.. |
11 | 59 | ...........................................................................................................................................................................................................................................................DWEDLYRLNKEVSEVEDLFKRATGFRFWSA---QRTWVKRILRGKSFSIIAPTGMGKSTFGAFISIYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVYHGNLK-DGDFDILVTSS----QFLATRFDELKRFDLIFVDDVDAFLKASKNI--DRSLLLLQEVINLIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNI-VDTYIIPERSIEEEVENLLRKLGKGGLIFVPIDKGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPHLIRFAVFAFSMDLEQPTIYRVLGLEFLPQEKREEGEKLYARLRRLIRNIPQY--ELMKIEEALAEGIELEG--FKQAVEFLREVLRDEEVIRRISENPFLSLKEVEGKLYIEIPDVR-------------TYIQASGRTSRAGGITKGLSVIIVDDQ--------KVFNGLIRQMR------RFVEFEIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTE.......................................................................................................................................................................................................................................................................................................................................................................................... |
696 |
| 55 | -11.000 | [D] COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins |
ali follow.. |
14 | 227 | ...........................................................................................................................................................................KEKKAAKRSRNEDPAQEENDQPLEIVDFSQRVSHEAKNDATVKQQVKPAKQEDQVSKEAPEEDKLASQGQEGEEMPTVSLATAVTPNDDYQLPTIELLKLPNNPNQSMEKRLLHKNAEKLRKTLESFGVKAKVHLGPA-VTKYEVNPHV------VKVSRIVNLAD----DLALALAAKDIIPGKSAIGIEVP-IVTLREVLDSPQAKADRN-RDIS-VFAP--HLLTGSGKSVCINGIITSIPHEVKLMMID---PKMVELNVYNGIPHLLTPVVTEPKKASQALKKVVAEMERRYDLFSHSGTRNIEGYNEMITRQNEKEDAKQPT---------------------------------------------------LPYIVVI---------VDELADLMMVASGD-------VEDSIARLAQ--------------MARAAGIH---ILATQRPSVDVI--TGVIKA-----------NIPSR-IAFGVSSQTDSRTILDTGGAE--KLLGRGDMLYLPMGATKPTRVQGAFLSDEEVETIVSASVSMLQRRFRIGYTRAARLI--DEMEARGIVGPY--EGSKPREVLVQAQDDEASSH...................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
789 |
| 56 | -10.800 | [TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family |
ali follow.. |
8 | 1023 | ........................................................................................................................................................................................................................................................................DFYSELQSIIKCLTNENEPVCYLGLQKLEL----FFQAKVDELHDTLNLDISNEVLDQLLRCLLDCCVKY-TNMQISYLAAKLGELGAID-NGEESLKFILDFMQSQLIPAFLVTTDTKAQGFLAYALQEF---GLTVVTEHWMS----LPDLSKRVFLTSKYKENVTIHTWMEYAHSQNAEKIFGICSKVNIPCFLLPFLVLNVILTESELEVNKVIEEFQLVINQPGPDGLNSVGQQRRMRKKRNWDRRSAIARKENRYMSVEDATSRESSISKVESFLSR---FPSKTLGIVSLNCGFHARALFYWEQAPYAALESDYRVLQEIYAGIDDPDEAVSLNFHDYSFDQQLLLHENSGTWDSALSCYEIIIQKGLLNSMLQSGHYESLVLS------LDSFIINDNHEYSKMLN---IEASWRSLS---DSLKKCLSKSNLESFEAKLGSIFYQDSFAELTERLQPLYVDAATAIANTGAHS---AYDCYDILSKLHAINDFSRIAETDGIVSDNLDIV--RRRLSQVAPYGKFKHQILSTHLVGYEKFENTKKTAEIYLEIARISRKNGQFQRAFNAILKAMDLDKPLATIEHAQWW----------------------------HQGQHRKAISELNFSLNNNMFDLVDEHEERPKNRKETLGNPLKGKVFLKLTK-------GKAGQLGLKDLETYYHKAVEIYSECENTHYYLGHHRVLMYEEEQKLPVNEQSINEFGRSLYYGTNHIYESMPKLLTLLDFGAEELRLSKDDGEKYFREHIISSRKKSLELMNVCRLSMKIPQYFFLVALSQMI------------SRVCHPNNKVYKILEHI-------------------------IANVVASY----PGETLWQLMATIKSTSQKRSLRGKSILNVLHSRKLSMSSKVDIKALSQSAILITEKLINLCN... |
1991 |
| 57 | -10.700 | [O] KOG0731 AAA+-type ATPase containing the peptidase M41 domain |
ali follow.. |
14 | 320 | ....................................................................................................................................................................................................................................................................KDVAGCDEAKQEIMEFVHFLKNPKKYEDLAKIPKG--ALLVGPPGTGKTLLAKATAGES---------GVPFLSISGSDFMEM------VGV--GPSRV--------------RHLFQEARQAAPSI--IFIDEIDAIGNDERESTLNQLLVEMDTTAGVVVLAGT--NRPDILD-------------KALLRPGRFDRQITID-----KPDIKGRDQIFKIYLKKIKLDHEPSYYSQRLAALTPGFAGA-----------------------------DIANVCNEAALIAA----------RHEGATVTMAHFESAIDR--VIGGLEKKNRVISKLERRT-------------VAYHESG-----HAVVGWFLEHALLKVTIVPRGTAALAQYVPNENLLMTKEQ--------LFDMTCMTLGGRAA-------------------EQVLIGKISTGAQNDLEKVTKMTYAQVVGLLSFPPRDDGYDFSKPYSNKTGAI----IDEEVRDWVAKAYERTVELVEEHKVKVAEIAELLLEKEVLHQDDLLKILGER............................................................................................................................................................................................................................................................................................................................................................................................................ |
758 |
| 58 | -10.400 | [Z] COG5022 Myosin heavy chain |
ali follow.. |
13 | 144 | ......................................................................................................................................................................................................................................................................................YAIAEDSYKCMNQEHKNQTIIISGESGAGKTYIMRYFASVQALIQNEILATNPIEAFGNSKFGKYIQLFDGNATIIG-AKIQTERSRLVFQPNQERNQILAGSSSEQLEKWKL-QEFNYLKQGN---------------------CSTIEGVNDKEEFKATVDALKTVGIDNDTC---LAALLHIGNIEVKHSRNDAYIDSKNENINATSLLGVDPSSLVKWLTKRKIKMASEGILKPLNEFQAVVARDSVAKFLYASLFDWLVATINKAGVLDIYGFHFKKNSFEQFC-------INYANEK--LQQEFYRHVFKLEQEEYAAEGLQQCISMIESRLGIHYALDVTISDELLELFTNSDFVKDLVPADTKKIKTKPKSNTLLMSTINETNAHYIRCIKPNE-LRACGKISCAGFPSR-YMLVPSAVRTTESLTFSKAILEKHAD-PTKYQIGKTKIF-TPLLESARDKALLYEAFAVNYYRTRFLLSRKRVRSFQAVAHGF................................................................................................................................................................................................................................................................................................................................................................................................................................................. |
806 |
| 59 | -10.300 | [A] KOG1804 RNA helicase |
ali follow.. |
13 | 309 | .......................................................................................................................................................................................................................................................................................VLNENQKLAVKRILSGDCYILFGPPGTGKTVTIIEAVLQVHFADSRILVCAP----SNSAADLVCLRLHESKVLQPATMVRVNAT-IIITTCSSSGLFYQIGVRVGHFTHVFVDEAGQASEP-------ECLIPLDISGQIVLLGPVIKSAMAYGSFLERLMSRPAYKLVKNYRSHELPSRLFYHRELEVCADPTVVTSLLGWEKL-------------------------------------------------------------PKKGFPLIFHGVRGSE----AREGKSPSWFNPAEAVQVLRYCCL-----------------LAHSISSQVSASDIGVIPYRKQVEKILRNVDLMDIKVGSVEEFQG--QEYLVIIISTVREDDRYFLGFLSNSKRFNVA-RP-KALLIVLGNPHVLVRDPC.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
722 |
| 60 | -10.200 | [O] KOG2004 Mitochondrial ATP-dependent protease PIM1/LON |
ali follow.. |
12 | 386 | ...................................................................................................................................................................................NEQLKVIKKELGIEKDEKTTIIEKIDERIKTLAVPEYALKVINEEKTKLQFLDPHSSEFSVTRNYLEWLTSVPWGLTSPENRRLSVAKKALDE------YGMKDVKERIMEFIAGGKILCFHGPPGVGKTSIAK-SIATALN---REYFRFSVGGMTDVEIKGHRRTY--VGAMPGKMTENP----LVLIDEVIGGAGFHGDPASALLELL---------DPEQNANFNDHFLDVPVDLSRVLFICTIPDRMEMIDVSGYLAEEKVEIAHQHLIPQLRKDTSLATEQLELIKHYCRESGVRNLQQHIERIFRKAALQIAEQQNEDEEPAEKATTAITENSEAEPITSTSSADCLKSSAEQIVVCTENLQKFVGRPKFTSDRMYEVTPPGVIMGLAWTAGGSALYIETVLKRPVDLTNDKDGSIETTGNLGDVMKESVHIHHEGATP--KD------SAG---VTLVSSLLSLALDRPVVDMAMTGEISLTG---KVLPVGGIREKVIAARRVGAKR----VFLPNENRRDFDDLPEFMK---SELDIRFVSHYDELYEHL.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
969 |
| 61 | -10.100 | [O] KOG0734 AAA+-type ATPase containing the peptidase M41 domain |
ali follow.. |
15 | 282 | ....................................................................................................................................................................................................................................................................EHVKGVEEAKQELQEVVEFLKNPQKFTILGKLPKG--ILLVGPPGTGKTLLARAVAGEA---------DVPFYYASGSEFDEM------VGV--GASRI--------------RNLFREAKANAPCV--IFIDELDSVGHPYSRQTINQLLAEMDPNEGVIIIGAT--NFPEALD-------------NALIRPGRFDMQVTVP-----RPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGA-------------------------------ELENLVNQAALKAA----------VDGKEMVTMKELEFSKDK--ILMGPERRSVEIDNKNKTI-------------TAYHESG-----HAIIAYYTKDAINKATIMPRGPTLGHVLPENDRWNETRAQ--------LLAQMDVSMGGRVAEEGTDH--------------------ITTGASSDFDNATKIAKRMVTETQSAIEQEIRILLRDSYER--AKHILKTHAKEHKNLAEALLTYET............................................................................................................................................................................................................................................................................................................................................................................................................................................... |
698 |
| 62 | -10.000 | [V] COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases |
ali follow.. |
10 | 261 | ...........................................................................................................................................................................................................................................................................................YQIQATREIVQKEGGYIWHTTGSGKTVTSFKVAQLLASAPRNVLFIVDRIDLIDQ----TLENFKSFAYAHFKNRIRKGSSQILLISKAVKKGLENDDWNV-----IIMDEAH----SASGESVKLIKKALKKTTWFGFTGTPNFYSDEINDVKTTREISTHDIFGKRLHTYTIKDAIGDGNVLGFDVTYFKPHWVVEHPQEDFSEKDYEKEVYQSDVYRQEVVKDILDN---------------------TKTSSGALIAGKREE-FQAMFAVSGKQAAVNYYNIFKSK-----GSHLNVAMTFSRDESNEHGTKEQNEALKIAIKDYTEKFNVPSIL-----KRPYNQGKEKDRLDLVIVSDQLLTGFDSKFINVIY--MDK--------LKEGMLIQAISRTNR---KPHGKVR------------------------------FYRQGDEMRE----FVENALR-IYTRGGNDTLQEAEEETKNQLPKDLENDDI............................................................................................................................................................................................................................................................................................................................................................................................................................................... |
728 |
| 63 | -9.570 | [Q] COG3321 Polyketide synthase modules and related proteins |
ali follow.. |
11 | 157 | .................................................................................................................................................................................................................................................................................SGRISHTLG-LHGPAMTFDTACSSGLMAVHLACRSLHDGESDLALA---GGCAVLLEPHASVAASAQGMLSKSFAACAMVLGNTATNQDGGTETLMMAVYQAALAVAGVEPETIGVV---EAH-IGDPIEGSA--TASAGTVGLIKAILSNGLVPPLLHFDRLSDDLTEIETGLVPQEVTPWPVSSFGMSGTNVHVIVEE---------------------APSEACAPDVPETSPGTGDATVGRQLFMLSSTSIAALRETARQLATWVEEHQDSVVLSDLAYTLARGRAHRPVRTA-----VVAADLPELVEGLCEIADGDALYDAVVGHGDRGPVWVFSGQGSQWASM-PVFAATIEAITAPETVTSVFAVQV-TYGVR-PG-AVIGHSM----GESAAAVVAGDAARVICRRSKNRVAGSGAMGSVELPAKQVNSELMSVVASPQSTVIGGATETVRDLIAQWEQRDVMAREVVDVASHSSQVDPILDDLAAALADIAPMTPKVPYYSATLFDPRELPVCNGAYWVDNLRNTVQ................................................................................................................................................................................................................................................................................................................................................................................................................... |
787 |
| 64 | -9.330 | [U] COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase) |
ali follow.. |
12 | 11 | ......................................................................................................................................................................................................................SSNERKVKTLATRVAKINAYEAEYAALSDEALKGKTAEFKARLEKGETLDDI--AVVREASKRVLGMRHFDVQMVGGMVLHFSGISEMRTGEGKTLVATLPTYLNALEGKGVHVITVNDYLARRDADWMGQVYNFLGLSYGVIVNGLSSDITYGTNDYLRNLVYSVDEMVRGHNFAIVDEV----DS----------ILIDEARTPLIISGPTEDRSSFYKTIDVILDKSMFDHDEKQKQVILKDYIVKGGEVVLIDEFTGRMMSEGLHQAIEAKEGADIQPENQTLASVTIQNYFRLYKKLSGMTGTASTEAQE--RTEREKNEAILKQIADCH-QPILVGTVSIEKSEELSKLLSTFSFEKDGKKVK----IPHQVLNARFHEQEAVIVADAGVPGAVTIATNMAGLGGSIDMRLFNWRQQQRGMGLEITVEDEAEERARLETEIADKKAQALAAGGLFVLGTE--QLRGRTGRQGDPGRSKFFLSCEDDLLAGERLDAIM--RTFGVQEGEAITHKWLNNAIATAQKRVEQ------RNYEIRKNLLKYDDVVNDQRKAV.................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
671 |
| 65 | -9.240 | [L] KOG1514 Origin recognition complex, subunit 1, and related proteins |
ali follow.. |
10 | 308 | .................................................................................................................................................................................GDEDSDQEWNGRKEEEIDYSDEEIEFDDEESVRGVSKSKRGGANSRKGRFFGLEKVGMKRIPEHVRCHKQSELEKAKATLLLATRPKSLPCRSKEMEEITAFIKGSISDDQ----CLGRCMYIHGVPGTGKTISVLSVMK-NLKAEVEAGSVSPYCFINGLKLASPENIYSVI--LSGHRVGWKKAL---QSLNERFAEGKKIGKENEKPCILLIDELDVLVTRNQSVLYN--ILDWPPNSKLVVLG--IANTMDLPE---KLLPR----ISSRMGIQRLCFGPYNHRQLQEIISTRLEGINAFEKTAIEFASRKVAAISGD-----------------------------------------------------------ARRALERRAAEVADYRLKKSNISAKSQL-----------------------------VIMAD------VEVAIQEMFQAPHIQVM--------SVSKLSRIFLTAMVHELYKTGMAETSFDRVSSICLTNGEAFPGWDILLKIGCDLGECRIVLCEPGEKHRLQKL--QLNFPSDDVAFALK-DNKDLPWLAN.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................. |
769 |
| 66 | -9.170 | [V] COG3587 Restriction endonuclease |
ali follow.. |
12 | 2 | ..................................................................................................................................................................................................................................................................................SGFNYEKNPHQMRAVSAVDDQNILDISMETGTGKTYTYTQTMFELHRW-FKFIVVVPTLSIKAGTQQFLAEHFEQD-----KAENKKEIHVLLINAGMVNSSSMNDTDALAAVRFMIVDEPHKFPTRDSAKTWGNIKRLKP--QYILRYGATLTAVDAFNDGL--VKGVRVFQEEMQGGMDAAVKLVSSDGKEAKFELNEKDKKQTFKLAKGEDLAQIHPAISDLKIDKMNKTVVVLSNGLELKTGAVINPYSYSQTVQDAMMQRAVAEHFKLERAL-TLFFI-------DDIAGYRSGNELSGSLKDKFESWIRAEAARRLKTESDPFYRDYLQKTLDDVSACHGG----ILHDKEKLLSLDNPRRFIFSKWTLREGWDNP-NVFQICKLRSSGSTTSK-------LQEVGRGLRLPVNELMLNYFVDSSEKDFVKQLVGEINDNSFQEEISKKFTEELKQKILQKYPDIKPLVLVNQLFLDGIIDDNENFAEDGYDKLKA..................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
632 |
