current user: public

If you have questions about the server, please let us know.

Query: [I] COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350    .  360    .  370    .  380    .  390    .  400    .  410    .  420    .  430    .  440    .  450    .  460    .  470    .  480    .  490    .  500    .  510    .  520    .  530    .  540    .  550    .  560    .  570    .
# Score Template Links and tools%idFirst MKKVLIANRGEIAVRIIRACRDYGLQSVAVYADPDQDALFVRLADEAYALEGVRPAETYLDISKLIAIAKRAGADAVHPGYGFLSERAEFAQAVIDAGLIWIGPDPDVIEALGDKVMARRIATGVGAPLVAGSDGPVSSAAEVTAFAEQHGLPVAIKAAHGGGGRGLKVAWKMEEIAELYESAVREATVAFGRGECFLERFLDRPRHIEAQVIADKHGNVLVLGTRDCSLQRRNQKLIEEAPAPFLSDEQRQKIHDAAKAICAAAGYSGAGTVEFLLGVDGTISFLEVNTRLQVEHPVTEETTGIDLVIEQFRIAEGHKLRVLETPEPRGHSMEFRINAEDPGRGFLPTPGLISVFDAPSGPGIRMDSGVISGSSIPGVFDSLMAKLIVTGVDRDQVLRRARRALREFRIEGIATVLPFHRAAIETEDFIGTDGFKVHTRWIETDFAAMPDAMERPAPADDPSITRTYLEIDGKRVSVGLPSILLSSLGTVSGGNASAPSAAVEKKEGEMTAPVSGTLQSFKVKDGETVSEGDLLAVMEAMKMETQIVATRAGKVRLIVKEGDYLQAGATLIDIAGLast
1 -142.000[I] COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit  ali  100  1MKKVLIANRGEIAVRIIRACRDYGLQSVAVYADPDQDALFVRLADEAYALEGVRPAETYLDISKLIAIAKRAGADAVHPGYGFLSERAEFAQAVIDAGLIWIGPDPDVIEALGDKVMARRIATGVGAPLVAGSDGPVSSAAEVTAFAEQHGLPVAIKAAHGGGGRGLKVAWKMEEIAELYESAVREATVAFGRGECFLERFLDRPRHIEAQVIADKHGNVLVLGTRDCSLQRRNQKLIEEAPAPFLSDEQRQKIHDAAKAICAAAGYSGAGTVEFLLGVDGTISFLEVNTRLQVEHPVTEETTGIDLVIEQFRIAEGHKLRVLETPEPRGHSMEFRINAEDPGRGFLPTPGLISVFDAPSGPGIRMDSGVISGSSIPGVFDSLMAKLIVTGVDRDQVLRRARRALREFRIEGIATVLPFHRAAIETEDFIGTDGFKVHTRWIETDFAAMPDAMERPAPADDPSITRTYLEIDGKRVSVGLPSILLSSLGTVSGGNASAPSAAVEKKEGEMTAPVSGTLQSFKVKDGETVSEGDLLAVMEAMKMETQIVATRAGKVRLIVKEGDYLQAGATLIDIAG 576
2 -114.000[IE] KOG0238 3-Methylcrotonyl-CoA carboxylase, biotin-containing subunit/Propionyl-CoA carboxylase, alpha chain/Acetyl-CoA carboxylase, biotin carboxylase subunit  ali follow..  37  49FDKILIANRGEIACRVIKTARAMGIKTVAVHSDVDSNSLHVKMADEAVCVGEAPTAKSYLRADRILQAVEDTGAQAVHPGYGFLSENTKFAAELEKAGAKFIGPNSKAILDMGDKIHSKKIATAARVSMIPGYDGEIADEDMCVKVSRDIGYPVMIKASAGGGGKGMRVAWNDKQAREGYRLSKQEAASSFGDDRMLVEKFIDNPRHIEMQVLCDKHGNALWLNERECSIQRRNQKVIEEAPSSFVPPEMRRKMGEQAVQLAKAVGYDSAGTVEFLVDSQRNFYFLEMNTRLQVEHPITECITGIDIVQQMLRVSYGHPLPITQQVPLNGWAFESRVYAEDPYKGFLPSVGRLSRYVEPKHDGVRCDSGIREGSEISIYYDPLICKLVTHGDNREQALNRMQEALDNYVIRGVTHNIPLLRDIVQEKRFRTGD---ITTKYLPEVYPEGFQGTSLSPKEQDVVIAFASALNARKLARANQFLNQNKQPEQAVKYLQYMKEKAKVDLSTVVLSPMPGAIKNVNVKPGDMVSEGQELVVMEAMKMQNSLHAGKTGRVKVNVKVGATVDEGEVLVELE. 724
3 -114.000[I] COG0439 Biotin carboxylase  ali follow..  42  2FKKILIANRGEIALRVIRTAREMGIQTVVVYSTADEKSLPVLLADESVCVGPPASNQSYLNIPNILSAALMTGAEAIHPGYGFMAENPDFAEMCREHGIVFIGPTPESMRALGSKAGGREIAAQSNVPTVPGTGV-LESVDAALLAAKQIGYPVLLKASAGGGGRGQKVIRTQEELQKGFNQAQEEARLYFGDPAIIMEKFLEEFRHIEVQVMGDGQGHVIHIGERDCSIQRRNQKLIEEAPST-LPESLRQEILAAGVRLAQFVNYAGAGTLEFIMDRDGNYYFMEMNTRIQVEHCVSEMISSLDLVRLQIEIAAGLGLNIQQDVKLHGHAIECRINAEDPDKDFRPAAGKIDDAHFAGGAGVRVDTHVYSGYSIPPHYDSLIGKLIVWHEDRDKAVSRMKRALEETVIQGPKTTIPLYIKIMDNPFYKRGAVMT............................................................................................................................................ 436
4 -108.000[C] COG1038 Pyruvate carboxylase  ali follow..  37  24ISKILVANRSEIAIRVFRAANELGIKTVAIWAEEDKLSLHRFKADESYQVGRGPPIESYLSIEEVIRVAKLSGADAIHPGYGLLSESPEFVEACNKAGITFIGPTPDTMRQLGNKVAARNLAISVDVPVVPATNPLPDDIAEVERMAEEIGYPVMLKASWGGGGRGMRAIRKKEDLAREVTEAKREAKAAFGKDEVYLEKLVERARHVESQILGDTHGNVVHLFERDCSIQRRNQKVVERAPAPYLSEAQRQELAAYSLKIAAATNYIGAGTVEYLMDADGKFYFIEVNPRIQVEHTVTEVVTGIDIVKAQIHILEGAAIGTQEDIRLNGHALQCRITTEDPEHNFIPDYGRITAYRSASGFGIRLDGGTYTGAVITRYYDPLLVKVTAWAPEPDEAISRMDRALREFRIRGVATNLTFLEAIIGHDSFRNNT---YTTRFIDSTPELFAQVKRQDRATKLLTYLADVTVNGHPETKGRAKPADKAAKPIVPYIDAPTPRGANGVGYKNYPDNVVKYFVRQAARGGDLFRVFDCLNWVENMRVSMDAIAEENKLCETICYTGDLLNSARPKYDLK. 718
5 -53.700[EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)  ali follow..  14  562IRIGQGVEFDYATVHSVKAIQAAGYEAIIMNSNPETVSTDFSVSDKLYF-----EPLTFEDVMNVIDLEQPKGVIVQFGGQTAIN----LAEPLAKAGVTILGTQVADLDRAEDRDLFEQALKELDIPQPPGQT--ATNEEEAALAARKIGFPVLVRPSYVLGGRAMEIVENEEDLRSYM----RTAVKASPDHPVLVDSYIVGQECEVDAISDGKNVLIPGIMEHIERAGVHSGDSMAVYPPQTLSQKVQETIADYTKRLAIGLHCLGMMNIQFVIK-DEKVYVIEVNPRASRTVPFLSKVTNIPMAQVATKLILGQSLSELGYQNGLYPEST-RVHIKAPVFSFTKLAKVDSLLGPEMGSDATLEKALYKAFEASYHLPTFGNVVFTIADDAKEEALNLARRFQNYGILATEGTAAFFAS.......................................................................................................................................................... 976
6 -40.900[F] COG0027 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)  ali follow..  20  13.TKVMMLGSGELGKEVVIELQRLGVEVIAVDRYANAPAQQV--AHRAYTI-------SMLDGEALKALVEKEKPDYIVPEVEAIATAT--LVELEQAGFT-VIPTAKATQLTMNREGIRRAAEELGLPTSNYQF--VDNFDDFKRAVEKIGIPCVVKPIMSSSGHGQSILKSVEQIPSAWEYAQQGGRA--GAGRVIVEGFVKFDYEITLLTVRHVHGTSFLAPIGHIQIDGDYRESW--QPQA-MSAVALEKAQAIAEKITGALGGRGIFGVEMFVCGDE-VIFNEVSPRPHDTGMVTLISQELSEFALHARAILGLPIP---DITLISPSASKAIVVEGKSTQ--VVFGQLAEVLAEPHTNLRL------GKGEVDGHRRM-GVILARDISVEKALEKARRAYDKLEIA..................................................................................................................................................................... 392
7 -37.600[F] COG0026 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)  ali follow..  19  12.LTIGIIGGGQLGRMLAMAAARLNHRTIVLEPQADCPAAQV--CNDQIVA-------EYDDEKALAELASRCDV------VTYEFENVPVAAAEKLSASVPVYPPAQALSASQDRLTEKRFLNGCGIPTADFRA--VDSQDELEAALTAFGGKGVLKTRRMGDGKGQRLFRGGENL--------TGAFAALGGVPLILESFVAFEREISIIAARFQDGTVTCY-DPAENVHLNGILHTSTVPAA-LSDAAKAVAVQSAEKLLAALEYVGVIGIEFFVLPDGSLVANEMAPRVHNTGHWTEAACAISQFEQHIRAVSDLAPG---STDRHSDCVMTNLIGDD........................................................................................................................................................................................................................................... 322
8 -33.800[F] KOG2835 Phosphoribosylamidoimidazole-succinocarboxamide synthase  ali follow..  13  4.RTVGILGGGQLGRMIVEAANRLNIK-TVILDAENSPAKQISNSNDHV-------NGSFSNPLDIEKLAEK--CDVLTIEIEHVDVPT-LKNLQVKHPKLKIYPSPETIRLIQDKYIQKEHLIKNGIAVTQSVPVEQASETSLLNVGRDLGFPFVLKSRTLADGRGNFVVKNKEMIPEALE--------VLKDRPLYAEKWAPFTKELAVMIVRSVNGLVFSY-PIVETIHKDNICDLCYAPAR-VPDSVQLKAKLLAENAIKSFPGCGIFGVEMFYLETGELLINEIAPRPHNSGHYTIDACVTSQFEAHLRSILDLPMPKNFFSTITTNAIMLNVLGDKHTKDKELE-TCERALATPGGKESRPNRKVGHINIIASSMAECEQRLNYITGRTDIPIKISVAQKLDLEIMGSDSDLPVMSAACAVLKDFGVPFEVTIVSAHRTPHRMSAYAISASKRGIKTIIA-----------------------------------------GAGGAAHLPGMVAAMTPLPGVPVKGSC----LDGVDSLHSIVQMPRGVPVATVAINNSTNAALLAVRLLG 531
9 -22.700[R] COG2232 Predicted ATP-dependent carboligase related to biotin carboxylase  ali follow..  14  5.EEILVI--GVNTRPVVESAFRLGYRVYSAGYYCTADFK--HYTERRCIL-------RERSGESCGRFHENFSQEKLLEAASDFIERADLTGAPPLPGEKVLGN--SRVDHVEDKYRLYRRI-RNSYPTPETH--LISDPAEAMEIVAAGEKKYIAKPVSGAGGFGVTEFREGDG-------------------EFLLQEYIEG-VPVSASVLSTGEDAITVLTSRQIIDRGVPGFEGQFVYAGNMTPGPSGEIEDLASDLILDLSLRGSNGVDLIMRDSE-LYVIEVNPRIQGTFECAEASLGINMVDAHIRACMGELIEKPDPVSYAVKRI------------YAPARCRVGEIKTMGVHDL------VPGTIIEE--GEPLLTVLASHNSMEAAENLASNICSRVKKE..................................................................................................................................................................... 363
10 -19.700[R] COG3919 Predicted ATP-grasp enzyme  ali follow..  17  4.PGVVIIGGAHGTLALARSLGVLNVPVYYL-THDSPLPGWSRFVRETIRW-AGPHDDGAMAFLREMAEKPGLKGCLLVP---LVSQHRE------SALYKIILPEWTNLQWLCEKPLLYKRAAELGVS-IPRT--ALTSAADIDGL--DVMFPVILKPHMGGGNTSIARADDREELKAAFVDASGEI----GPDNVVVQELIPGGESQFSYAALWLNGEPIAEFT--------ARRARQYPVSTRVEVVDNRQAIEAARKILKSAGHSGLVEVEFKLDGDGALKLLDVNPRPWSWFGLC-SAAGINLGGLLWRVANDMPTG............................................................................................................................................................................................................................................................... 316
11 -19.600[R] COG1821 Predicted ATP-utilizing enzyme (ATP-grasp superfamily)  ali follow..  11  2..KLFLFEFATCGERIEDSTAVEGLAMFSAFDGFKNYYEITGFVRPEFSCLFTLPVDS---MDSMEKYLEKSDAFLI---APEDDFLLYTLTKKAEKYCENLGSSSRAIAVTSDKWELYKKL-RGEVQVPQ-------------TSLRPLDCKFIIKPRTACAGEGIGFSDEVPD-------------------GHIAQEFIEG-INLSVSLAVGEDVKCLSVNEQIINNFRYAGAVVPAR----ISDEVKREVVEEAVRAVECVGLNGYVGVDIVYS--DQPYVIEINARLTTPVVAFSRAYGASVADLLAGGEVKHVRR............................................................................................................................................................................................................................................................... 277
12 -18.800[R] COG1759 ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)  ali follow..  13  17.DKITIGVIGS-ALDIADGAKEEGLPTLVV-MRKTRDGLVKGFIDEVIVLD---------KFAQIIEIQEELRKRVIFVPNRSFVVYTGIDRVENEFLVPMFGTRSLRTEERSEEKSYYWLLEKAKLPY--------PEPVSPEEIDDVGLVIVKLPHAKKRLERGFFTAASYKEFKEKSEKLIRLGVITREDAKARIERYIIGPVF-NFDFFYSPIDGEIEL----LGIDWRFETSLDGH-SSTLRESLLEKVFDMAEKYVEATGIIGPFTLQTAVDKDLNFYIYDVAPRTGGGTNIH-MAMGHPYGNSLWRMSTGRRIALEIKRAIELDELEKIVT.............................................................................................................................................................................................................................................. 380
13 -17.600[M] COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes  ali follow..  19  2..KIAVLYGGEVSLSIMEALKANGHEVIGIDFHPDQVRDLVDLDVDLVFI-------------------------GLHGRLG---EDGKVQALLDLLNIPYVGTGVQGSALAMDKAKAKLFFEKAGIRVAEEVV---SFTYDANAFNFTGTYPVVVKPNQEGSTIGLTVAETEEELLQGIEEAFRH------DDTILIEEFIAG-TEVTVAVLGNKGEERS-----DYESKYAPGMSEHIVPAR-ISEEHTAYVQQAAVRAHQALGCDVYSRVDFIVPNDGDPVILKVNT------PDAAKGVGMEMIQTFVNLS..................................................................................................................................................................................................................................................................... 302
14 -15.600[F] COG0151 Phosphoribosylamine-glycine ligase  ali follow..  15  2..NILIIGNGALAWKVAQS------LADKVFVAPGNAGTALEHKVENVNISAT-------DIPALVKFAQDKQIGLTIVG-------IGVVDAFREAGLKIFGPAKAAAQLEGSKAFTKDFLARHKIPT--AEYQNFTEVEPALTYLREKGTPIVVKADGLAAGKGVIVAMTLQEAEDAVRDMLSGNAFGEAGSRVVIEEFLDG-EEASFIVMVDGKNVEPMASSQD------HKRVGENSPAPVITPEIHSRIMKEVIYAAEGNVYTGFLYAGLMIMPNGQPKVIEFNCRFDPETQPIMLRLKSDLVELCLKACDGK----EVISQWDLRASLGIVLAAEGYPKDYRKGDEISGLPKSAVKNEKVLAGVAEQEGKLVTNGGRVLCVTALGESVFEAQQKALKLAEQIQWSGRFYRRDIGYRAVERE..................................................................................................................................................... 426
15 -15.200[F] KOG0237 Glycinamide ribonucleotide synthetase (GARS)/Aminoimidazole ribonucleotide synthetase (AIRS)  ali follow..  13  5..IALLIGNGGREHTIAWKLCESPLISKVYVAPGNGGTASNGAESKMENVN------GVCDFEQLVKFALDKDVNLVIPG-------EGIEGHFRRVGIPCFGPSALAARMEGSKVFSKDFMHRNNIPT--AVYKSFSNYDHAKSFLDTCTFDVVIKADGLAAGKGVIIPKTKKEAFEALESIMLNEEFGSAGKNVVIEELLEGE---ELSILTFSDGYTCRS----LPPAQDHKRAFDGAPTPVASPKLLETVQSTIIQRHEGYPLVGILFTGLMLTPSG--RVLEYNVRFDPETQAVLPLLESDLAEIILACVNHR----AIDIVISRKFSCAVVCVAGGYPGPYNKGDIITFDALKDKNTRIFHAGTSIRDGNVVTNGGRVLAVEATGDSVEAAVRLAYEGVKTVHFDKM................................................................................................................................................................... 416
16 -12.000[I] COG0511 Biotin carboxyl carrier protein  ali follow..  24  92..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GSQPGAKIIDQKLAEVASPMVGTFYRAFVEVGDRIRQGQTVCIIEAMKLMNEIEADVSGQVEILVQNGEPVEYNQPLMRIK. 180
17 -10.400[HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)  ali follow..  15  24MRIAFFVNSIE-TGLLAMAALNRGHDVVYL----TPGDFTLRSDDTLAVHATVIRKGKYKKPEAFHAALQDEEIDAL-PSLDQVHAGILFGRLAEQRGVVVLN-DPEGLALAQNKLYFQSFP-EIVRPTT------SRNVEEIRAFADTHPKGVIVKPLQGSGGKNVFKIGSSKETNLNQIFEAVSL-----EGYLIAQAYLPAAKEGDVRFF---NGRPLMRDGQYAALRRRSNIHANGTAEAVKVTDEIVELAEMMRPKLVEDGMFLVG-LDIVGD-----KILEVNVFSPGGLSNILELTNVDFSDTIIE....................................................................................................................................................................................................................................................................... 347

FFAS is supported by the NIH grant R01-GM087218-01
1 4 1 5 6 8   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster

Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Jaroszewski L, Godzik A. Sequence clustering strategies improve remote homology recognitions while reducing search times. Protein Eng. 2002 Aug;15(8):643-9.