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Query: [S] COG4861 Uncharacterized protein conserved in bacteria, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDQIGADLAEAVERHLTEYGVRVLGGLSALNSAHPESLDLEIDAHPLTITALYLPHLSATAALQAWDTAGAGSPLLVVGPRLHPSSAETLRARGLWYIDGAGNAYLRHQGGLLIDVRGRRSAVSAQPGTLGDGLHSDGPRNPFTPKRAQVVCVLLDAPQLVDAPLRAIAASAGVSVGMAKETMDTLRTTGFFEHLGSRRRLVRTDELLDLWAAAYPGGLGRANKLLVASGDIHTWSAPDGLAVAVSGEQALPDEIRNPESLMLYVDTPAPGLPADLLIHNRWHRDPHGSIVIRKLFWRNLPDEQPGLAPTALIYADLLASREPRQVEVAHLMRRQDERLARLLast
1 -108.000[S] COG4861 Uncharacterized protein conserved in bacteria  ali  100  1MDQIGADLAEAVERHLTEYGVRVLGGLSALNSAHPESLDLEIDAHPLTITALYLPHLSATAALQAWDTAGAGSPLLVVGPRLHPSSAETLRARGLWYIDGAGNAYLRHQGGLLIDVRGRRSAVSAQPGTLGDGLHSDGPRNPFTPKRAQVVCVLLDAPQLVDAPLRAIAASAGVSVGMAKETMDTLRTTGFFEHLGSRRRLVRTDELLDLWAAAYPGGLGRANKLLVASGDIHTWSAPDGLAVAVSGEQALPDEIRNPESLMLYVDTPAPGLPADLLIHNRWHRDPHGSIVIRKLFWRNLPDEQPGLAPTALIYADLLASREPRQVEVAHLMRRQDERLARL 342
2 -14.200[S] COG5482 Uncharacterized conserved protein  ali follow..  13  1...METSLYLPVKGFLEKAGYTVKGEVGGCD-----LVGLSDDDPSVVVICELKLSFNLELILQAVDRAAIADEVWIAARVADKRYRDLCRRLGI------GMLGISDTGDVSILVGSVTPMPRTNPKRRSRLMREHQRRTAYRQQALGCAVALVSGPLRVRQIRSSVPDAGKILLANVYGWFERLDRGVYGLTEAGQEALQRWPQPAT..................................................................................................................................... 218
3 -13.100[S] COG3398 Uncharacterized protein conserved in archaea  ali follow..  10  99.........................................................RITERADVFENSNRARIYEYIKTRPGAYLSEIIEKAGIDRGAARYHIKILKAHHKIEAYRESGKTRYFQNNSTYGEEEKKVVSALQNATNQRIISEIQNGKCN---TNLALAREIGVSRATISWYVKNLKETGLIDETRSGRSIISYEPLIEKYG.................................................................................................................................. 255
4 -12.500[K] COG5625 Predicted transcription regulator containing HTH domain  ali follow..  12  19..............................................................................................................................................LKKNEIRIYRLLVEKRR--GMRIREIQRELGISERSVRTHVLNLYRRGLLKRELVQYTPVSPLEILQKIKEHLMKSIEE......................................................................................................................... 102
5 -12.400[K] COG3355 Predicted transcriptional regulator  ali follow..  11  25..............................................................................................................................................LSKSDVEVLHILLQNGKM---TTDDLSQKLNVTKASISKALNNLLDKGLIQREKA................................................................................................................................................. 76
6 -12.100[K] COG4190 Predicted transcriptional regulator  ali follow..  10  40...................................................................................................................IAALEQGDAMDSTPTLSFTSYDDLMDTLTPRVLELIEAIRQEEPA---SINETARVVDRDVKNVHEELSRLAHLGIIFFEEDGQR.............................................................................................................................................. 121
7 -11.300[S] COG4519 Uncharacterized protein conserved in bacteria  ali follow..  10  4...............................................................................................................................................SPVFARRLYLALLVESLERPNVPKLIEKTGWPRRTIQDVIKAMPGIGIELNFVQD................................................................................................................................................ 58
8 -11.100[K] COG1510 Predicted transcriptional regulators  ali follow..  8  1.................................................................................MKKTALDIIEHAEEHLIEKIAE---------NMHTFG------------------------MPSTVGRVLGIIYMNRK--PMTLSELSEATGMSKTRMSQVVREMIDANIAEK.................................................................................................................................................... 78
9 -11.100[KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon  ali follow..  15  1..............................................................................................................................................MKMKTLFLLIKLAKMGKEITVTMRELSRELDVSPQTVLRWLEELKEQGYIHKRESRK............................................................................................................................................... 60
10 -10.900[K] COG4742 Predicted transcriptional regulator  ali follow..  16  12...............................................................................................................................................SQKRRDLLLLLGEEPR----TMEDIKVLLDVSPTAILPQIKRLTDSNLVIQKNGSYELTDMGEQV...................................................................................................................................... 72
11 -10.800[S] COG2512 Uncharacterized membrane-associated protein/domain  ali follow..  13  220....................................................................................................................AVSLTEPIIEPAGNPDIETAALNRIPLSPELCEVLDIIRGHKGRI--TQKDLRSKLDYSEVKVSLMLSELEKRGLIRKLRNGRE.............................................................................................................................................. 301
12 -10.500[K] COG1959 Predicted transcriptional regulator  ali follow..  14  4............................................................................................................................................TSFTDYGLRALIYMASLPEGRMTSISEVTDVYGVSRNHMVKIINQLSRAGYVTAKNGGIRLGKPASAIR..................................................................................................................................... 75
13 -10.400[K] COG4738 Predicted transcriptional regulator  ali follow..  13  34..............................................................................................................................................INRPVALTLACLSKGDEI---SSQRIEMVSGLRQPEVSIAMRYLRENEWVDMREEK................................................................................................................................................ 86
14 -9.830[S] COG3388 Uncharacterized protein conserved in archaea  ali follow..  12  18................................................................................................................................................KRHISVINVLLREQPI---GIIKLSQETGIPEHKIRYSLRILEQENIISPSREGAILTP........................................................................................................................................... 73
15 -9.710[K] COG1846 Transcriptional regulators  ali follow..  17  40..............................................................................................................................................LTPSEIHTIDAIGTDEGL---LMKELAERLGVTKGAVSQLVDRLEAKALVRRTAH................................................................................................................................................. 91
16 -9.220[K] COG1378 Predicted transcriptional regulators  ali follow..  18  35..............................................................................................................................................FRDYEARVYATLA---TRGEATASEIHRVSGVPRNKVYEVLRSLEDRGMIETIKSSFRAIDPESVLEEYKEQLVSAVDT......................................................................................................................... 113
17 -9.210[T] COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases  ali follow..  10  158...............................................................................................................................................RTAIERAAYLIAFLYRKIPVTQQHVADTLGLSIVHTNKTLRKLVDRGLIRWIDKGCLVLDEAGLSH..................................................................................................................................... 235
18 -9.100[K] COG1777 Predicted transcriptional regulators  ali follow..  10  10............................................................................................................................................AAIENSTRREIIRMLTQFE--RSYALELSRSIGLSQQAILKQLEMLERANLVTSIGFVPS.............................................................................................................................................. 67
19 -9.100[K] COG1725 Predicted transcriptional regulators  ali follow..  9  6........................................................................................................................................HADKPIYSQISDWMKKQMITKGEDKLPSVREMGVKLAVNPNTVSRAYQELERAGYIAKRGMGSFVTSDKALFDQ.................................................................................................................................... 83
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Jaroszewski L, Li W, Godzik A. Comparison of sequence profiles. Strategies for structural predictions using sequence information. Protein Sci. 2000 Feb;9(2):232-41.