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Query: [O] COG4934 Predicted protease, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKIALSAAIVLVMLFSAVYVAFNSNAGQTNQNSLNSLFSQPLVKSNDNIAKTVEKAGFKPYVPVNGSMEMNVIIGIIPNNLNELENYATEISMPGSPLYRHWLTTQQINSMFGNYQGVETVSSYFSKLGFSVQVKTPFAVAISGNASMMESVFHTTIYYFTNKNGQVLFSNLNSIELPGSVARYVLSVDGLSNFQMTTNPVYPTLSDYTSSGLIKNFEPLSSGTQSYLNHSDVVGFYAKKYAWVQLPLTNGPYPGSNVTGYTPPFQALFPSDLPWIYNIAPGLNGTSSTPGANGTGTTIAIVMGTGYINATLAYPAWNYNDMLKYGKEVFDNPSQILSRVTYLNAPGITHSPPPDPSPSFYVPYTDGYLGEFTLDTQYSATVAPDAHLDIMAIPSLSTVALDNAYITLYELPNTPQVITNSWSGSEDSWWNMYGPYWQSADLMNLLFELLSMKGSTIVAATGDSGGYDGYTNMISGEFPGTSPWVTGVGGDQVTMFNNTGVEFPVTGNYSRFNVTFGTANYSSLPPYYWSNLRLNIVNIGLKHNNGFTQTYWDNNQYVVVNGAPEVISTGAGSAALSIFFKQPWWQHGYSVPNTGRMSEVEVSAEAGFNQTELVDGMWGSWFFGGTSEATPTTAGMIADVISYLNATIHVNYLGDINPLLYEIGNEYMQNPGKMPDPYFTVSNGTNSLSALMVNDSYTLDGPQNYPSNYYTTDNGYSMLTGWGTINVGNFKIDLEQFLTQPFNVTEDNSTGTGTPFYGNFTESTYITMGQPAGLQYGTQYLFNVSGSVSGLTNIPKNLNLTFITSNGEYNLNNSNKPGNMHFAYNAGLLKIYSDTFNTTGFLEVNGTFDHRLAYSFTWIGSKQIANATNNISVEKNMSVSIAYPYLMAGFPAFAYTGLFNGTAGYFATYVPPIEPNMQIVNVTYKGKPVYNALVLLTYKNASNEIKNLTFLRQYAISYSFTNLNGSAYLDTWNVAVDTKAYVYVVYSGMVKESNFTLTPQSTSSILFNNSLESILLPYYNLLPVFQGQYLPFTVNQENAEVALYVPGSLNFYGPSTPTTVIPSTITNTNAKGFVNFKIPNWLPPGSLLYLGITNSSQPVYSAANGLILDHNVSYLPVYVAGSGPSVMLASNALTNIFGVPVVTPTTSFEAVYTDSLSPYGGYVNYMWYSVDGMTPISFGQDGYAVAAASQTQIFGLNSSIPSGLNTLYVYFNDTLGLTYETSMEFYFNASIPTPSLMLSSPSYYEHGNFSVSYKDNLNPNLTILNELYISYNGNIIASEPITTSSGVLQINGNDLPYGILNLTFTIETANGQTNETSITVMNLPADEYYPTVNIIAPVTGSSQTGSLNITFTYTGFDDTVILYVNGSSGNVITANVTGKNLYTITEGKGSSSLPAGNYTVTVLVISKDGQVAKQSANFDLKAPVVPPVQSSIIIEYLVIGIVGGLIVGSLAVVAVMRRHLast
1 -372.000[O] COG4934 Predicted protease  ali  100  1MKIALSAAIVLVMLFSAVYVAFNSNAGQTNQNSLNSLFSQPLVKSNDNIAKTVEKAGFKPYVPVNGSMEMNVIIGIIPNNLNELENYATEISMPGSPLYRHWLTTQQINSMFGNYQGVETVSSYFSKLGFSVQVKTPFAVAISGNASMMESVFHTTIYYFTNKNGQVLFSNLNSIELPGSVARYVLSVDGLSNFQMTTNPVYPTLSDYTSSGLIKNFEPLSSGTQSYLNHSDVVGFYAKKYAWVQLPLTNGPYPGSNVTGYTPPFQALFPSDLPWIYNIAPGLNGTSSTPGANGTGTTIAIVMGTGYINATLAYPAWNYNDMLKYGKEVFDNPSQILSRVTYLNAPGITHSPPPDPSPSFYVPYTDGYLGEFTLDTQYSATVAPDAHLDIMAIPSLSTVALDNAYITLYELPNTPQVITNSWSGSEDSWWNMYGPYWQSADLMNLLFELLSMKGSTIVAATGDSGGYDGYTNMISGEFPGTSPWVTGVGGDQVTMFNNTGVEFPVTGNYSRFNVTFGTANYSSLPPYYWSNLRLNIVNIGLKHNNGFTQTYWDNNQYVVVNGAPEVISTGAGSAALSIFFKQPWWQHGYSVPNTGRMSEVEVSAEAGFNQTELVDGMWGSWFFGGTSEATPTTAGMIADVISYLNATIHVNYLGDINPLLYEIGNEYMQNPGKMPDPYFTVSNGTNSLSALMVNDSYTLDGPQNYPSNYYTTDNGYSMLTGWGTINVGNFKIDLEQFLTQPFNVTEDNSTGTGTPFYGNFTESTYITMGQPAGLQYGTQYLFNVSGSVSGLTNIPKNLNLTFITSNGEYNLNNSNKPGNMHFAYNAGLLKIYSDTFNTTGFLEVNGTFDHRLAYSFTWIGSKQIANATNNISVEKNMSVSIAYPYLMAGFPAFAYTGLFNGTAGYFATYVPPIEPNMQIVNVTYKGKPVYNALVLLTYKNASNEIKNLTFLRQYAISYSFTNLNGSAYLDTWNVAVDTKAYVYVVYSGMVKESNFTLTPQSTSSILFNNSLESILLPYYNLLPVFQGQYLPFTVNQENAEVALYVPGSLNFYGPSTPTTVIPSTITNTNAKGFVNFKIPNWLPPGSLLYLGITNSSQPVYSAANGLILDHNVSYLPVYVAGSGPSVMLASNALTNIFGVPVVTPTTSFEAVYTDSLSPYGGYVNYMWYSVDGMTPISFGQDGYAVAAASQTQIFGLNSSIPSGLNTLYVYFNDTLGLTYETSMEFYFNASIPTPSLMLSSPSYYEHGNFSVSYKDNLNPNLTILNELYISYNGNIIASEPITTSSGVLQINGNDLPYGILNLTFTIETANGQTNETSITVMNLPADEYYPTVNIIAPVTGSSQTGSLNITFTYTGFDDTVILYVNGSSGNVITANVTGKNLYTITEGKGSSSLPAGNYTVTVLVISKDGQVAKQSANFDLKAPVVPPVQSSIIIEYLVIGIVGGLIVGSLAVVAVMRRH 1459
2 -25.600[O] COG1404 Subtilisin-like serine proteases  ali follow..  14  34...................LILEKALDRFTIRFVTDFPVQQLSQISWGIWHSSITQAQLELYQVAPNQIEEAIAQARANQNVAFASHAYTVKDNPGTFV---YLSDQITIQFAPKLDAVKITLIASQFNLVEDKP-PNAFVFLVSKQATENPVKIANQLQSIPE---------LAAEPNVLIQTETHYKPSDNLYPQQWYLNHNGGNELVASS----------------------------------------------------------AVEQAWDI-----------TRGVRSVVVAVVDDS-----------LNHPDFQG-----------SGKIVAPRDLRENDFLPLPSEKERSHGTACAGIALAEENGA--IVGVAPGCALMPIRTTGFLDDESIEQIFNWAMEKG-ASVISCSWGASAVYFPLSLRQRAAITRAATR----RNGKGCVVLFAAGNANRPVSGGVTDWLNGFGVHPDVMTIAAST------------------------------------------------------------SMSKKAAYSNWGLNISLCAPSNNASPGMSFPEKGFLYTQPSIKTNLSGLGMLTTDIVGAAGYDPGNFTSNFGGTSSATPVVAGVAALVLS-------------VNPDL----------------TAQQVKR----LETTADKIVDPDPDPQLGLSEGKYDENGYSQWFGYGKVNAARAVQVAFQQRTTLSDASKQVKLSNSN................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 589
3 -15.800[O] KOG3525 Subtilisin-like proprotein convertase  ali follow..  11  1MRISIGRIAWQILAVLIAVAFTIEHDSICDE---------------------------------------------SIGACGEPIHTVIRLAK-------------------RDDELARRIA---ADHDMHV----------------KGDPFLDTHYFLYHSETTRTRRHKRAIVERLDSHPAVEWVEEQRPKKRVKRDYILLDNDVHHSNPFRRSVLNRDGTRRAQRQQPQSPREIPSLPFPDPLYKDQ-------------GGAVGGYDM----NVRQAWL-----QGYAGRNVSVSILD-DGIQ--------RDHPDLAANYDPLAS------------DINDHDDDPTPQNNGDNKHGTRCAGEVAALAGNNQCGGVAFKAKIGGVRMLDGAVSDSVEA-ASLSLNQDHIDIYSASWGPEDDGKTFDGPGPLAREAFYRGIKNGRGGKGNIFVWASGNGGSRQDSCS----DGYTTSVYTLSISSAT--------------------------------------------------------------------------------YDNHRPWYLEECPSSIATTYSSADFRQPAIVTVDVPGG---------TDKHTGTSASAPLAAGIIALALE-------------ANPEL----------------TWRDM---QHLVLRTANWKPLENNPGWSRNGVGRMVSNKF----GYGLIDGGALVNMWKTVPEQHICTYEYRLANPNPRPIVGRFQLNFTLDVNGCESGTPVLYLEHVQVHATVRYLKRGDLKLTLFSPSGTRS......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 565
4 -14.000[S] COG1470 Predicted membrane protein  ali follow..  16  498...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LSRPFTIVIENLGKSDDEYKLEIRGIPENWNAFFTESAEGNIEVTKVKVKSGETKTVYLKVYPSLNAMPGTY-NATITVISSSGIKKEIPVKIKLIGSYNMNVNLLNYRLTITAGEEKTAMMDIFNFGNAPLTNLKITVKG-PSQIPSLSPKGRERVTITVKPEGTPAGDYRVQITV-KADQAEWQDTLRVV-------------VRQRSTSTYIGVLIL-SFALVLMMRRI 725
5 -12.900[O] KOG1153 Subtilisin-related protease/Vacuolar protease B  ali follow..  11  203....................................................................................................................................................................................................................................................................................................AGKGVTSYVLDTG---------------------------------DTEHEDFEGRAEWGAVIPANDEASDLNGHGTHCAGIIGSKHFGVAKNTKIVAVKVLRSNGEGTVSDVIKGIEKEFKGSTANLSLGSSKS-------------LAMEMAVNAAVDSGVHFAIAAGNEDEDACLSS------PAGAEKSITVGAST----------------------------------------------------------------------FSDDRAFFSNWGTCVDVFA------------------PGINIMST------IGSRNATLSLSGTSMASPHVAGILSYFLSLQPAPDSEFFNDAPSPQVLKFSTQGVLGDIGDDTPNKLIYNGGGK.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 472
6 -9.470[Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins  ali follow..  418...............................................................ERPELPLDRQSLVSGNHQKRLRRCLHDFTSPQAIAVDRSLSYAELDWR------ADRLASGLVAAGIGRGKR----IRLERSVELVVAILAV-------RTGAAYV----DPRYPADRIEFIAADADLALILVTTENDISTIGQNFRCMTPGMVE--------------------------------------NLAGGAVPTPVTSGADLA-IY-----------TSGSTGRPKGVAIEHRNAVAFMQWCMHAFTKDQLSGVLAST-----------------------------------------SICFDLEIFATLAAGGRIFMVDDLFAAGEPLPRELVARIYANDQVECLYNLYGPSEDTTYSTVAPVPPSGEWFTRAYVELFLSGSGLMYQTGDDG---------GLDYMGRADRQLKLNGFRIEPGE---------------------AVLLQQEGVHEAVAGLWRDAANHPRLAMWIAGDPALEITKLVATLRQRLPEHFIPVLATRLDALPRLPNGK----LDRSALPDPAAYGERATETAIRRNDNFFSLGGDSILA---IQLVSQARQK-GLKMTPRDV-FLHPTLASLAEVTHVESTVTVGT------------GHADDEATLGAIQHWLLDQDLPDLAHWNQGLILRSLDPDRLEKAISRLLEE............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 1084
7 -9.030[K] KOG1857 Transcription accessory protein TEX, contains S1 domain  ali follow..  158......................................NDIVASSSHNKSSTGRSSFWERRKVWNIDELLAETESIQPQAARNIVKLFEDENTPFICRYRRHIAPDRLRDIRN-RKRAENIIGKLQREN-IMTPEIREELMCAKSNEELEFLYA-----YKPASKGTLAERAKALGLQVYADCLLYGSAPKVNLSEIVDRRNEALATEALVMSGICIHNISKNTNVLEEIRRLQNVHRVFLKCSKTKEAKSSKSSSSSKASSSKGSNQNADKKLDSSKFENYFNFQGDVKTIKPY-QMLAINEKHKWLSVKIETNDYLKRDLMRYITDQYMNQGLQYPL---------------------------REVFTKSLEECYAKKLQPLMQIRAALKEKGTKAAIDVFAKNLISPLKGERILGIDPGFINGCK-------------------------LALISETADMSNKRAAEQKLVQLLSDHNCKIIGLGNGTACRET-----------------------------------------------------HWLTGMFHAGVLDSRIIRYSIVNENGASIYSC-SNVAAKEFPKMDTNERSAVSI--------------------ARRLNDPL-SEYVKIEPRHLG----------VGMYQHDVPEKILTAS---NDVVSECV---SYV--------------------------GVDLIAGLSEKKAEKIIEHRTQ................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 729
8 -8.670[R] COG3889 Predicted solute binding protein  ali follow..  10  514.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TIPKNAIVYNSTLKKWVPQHAGEKAKVRVTYTCKFGKWHDGTPMTMEDIKAAIAFSY-DEAMGASTRTLEQTLGFVFVNPTTYIVYSNITDDQIAGNNAWWATVPWYLRHAMEELVANPQKYGVTNNYTFTQAEGPRDHVEDLKKVIEKLIEEKDVPWYLQGEITPDEAVKAYKSLHAYDSNGPFYLDKYDPDKMLMVFKRFSGNPARLVPKGAEVPARVMAGKPLTVKVMLTADRGYVTVSINGNEVYSGEAKLTTAGTFELNVPGDTKGWSTGKYTAIIRGGLSKEVTSFTKTFVVIKPTTTSPQQTTTSTPQQTSGICGPAILVGLAVLPLLRDN 931
9 -8.640[S] COG4885 Uncharacterized protein conserved in archaea  ali follow..  10  61.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VEEFAIKAKIYDIQTDLLLNELEETFKSPESRFTAELTIPFEKTRDYKIVLYLQVGDRIYDSYRLTLRNLRNLVS--SLVDSDFLLTSVKNGSVGFVARFYDYDVVARIKVSNVLVGESWKNVTLQKGKTNIVSAEFEVPDDYNYVVKLDVWRNGKLVKSWADVLNLATKKLSKGEVEKEVDFEAEKFVTAALMALAGVALWRKAR 300
10 -8.340[E] COG2902 NAD-specific glutamate dehydrogenase  ali follow..  10  597......................................................................DMELSVAAGTTLDLPHYGPKLEEAFLAAFSGKVDNDNFNRLILACG-LRAYARYLRQTGYSQEHISETLYKYPDISRNIFALFKAGFD----PSIEEKKRVKKLAEIHKAIEAALSGVPNLDEDRTLRRYVNAIDATLRTNYFQKNADGTPRDLLAFK---------------------------------------FDPKHLDGLPDPRPFREIFVYGTEVEGVHLRFGKVARGGLRWSD------RGQDYRTEVLGLVKAQQVKNAVIVPVGAKGGFFPKNLPAGGSRDEVFNAGREARTLLSI-VDDAIVPPADTLFVVAADKGTATFSDTANGLAHEAG-AFASGGSAGYDHKKMGITARGAWETVKRH---FREMDTTPFTVAGVSGDVFGNG-------MLLSEKIRLIAAFDHRDIFIDPDPDTDKSFA------------KRLFELPRSSWQDYDRSTLSAGAM---------------------------------------------------IISRSEKSVTLTPEAVAAI------------GLDKSTP------EIMTAILKAPTDLLWFGGIGTYIKAAVETNAEVGDRANDPIR-IGEGANLGITQKGRIAY--------------ALAG-DNSAGVNSSDVEVNIKIALA................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 1165

FFAS is supported by the NIH grant R01-GM087218-01
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Comments and questions to: webmaster

Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lesley SA, Kuhn P, Godzik A., Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J, Taylor SS, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11664-9. Epub 2002 Aug 22.