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Query: [Z] COG5023 Tubulin, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MREIIHISTGQCGNQIGAAFWETICGEHGLDFNGTYHGHDDIQKERLNVYFNEASSGKWVPRSINVDLEPGTIDAVRNSAIGNLFRPDNYIFGQSSAGNVWAKGHYTEGAELVDSVMDVIRREAEGCDSLQGFQITHSLGGGTGSGMGTLLISKIREEFPDRMMATFSVLPSPKTSDTVVEPYNATLSVHQLVEHSDETFCIDNEALYDICQRTLKLNQPSYGDLNNLVSSVMSGVTTSLRYPGQLNSDLRKLAVNLVPFPRLHFFMVGYAPLTAIGSQSFRSLTVPELTQQMFDAKNMMAAADPRNGRYLTVAAFFRGKVSVKEVEDEMHKVQSKNSDYFVEWIPNNVQTAVCSVAPQGLDMAATFIANSTSIQELFKRVGDQFSAMFKRKAFLHWYTSEGMDELEFSEAESNMNDLVSEYQQYQEATVEDDEEVDENGDFGAPQNQDEPITENFELast
1 -123.000[Z] COG5023 Tubulin  ali  100  1MREIIHISTGQCGNQIGAAFWETICGEHGLDFNGTYHGHDDIQKERLNVYFNEASSGKWVPRSINVDLEPGTIDAVRNSAIGNLFRPDNYIFGQSSAGNVWAKGHYTEGAELVDSVMDVIRREAEGCDSLQGFQITHSLGGGTGSGMGTLLISKIREEFPDRMMATFSVLPSPKTSDTVVEPYNATLSVHQLVEHSDETFCIDNEALYDICQRTLKLNQPSYGDLNNLVSSVMSGVTTSLRYPGQLNSDLRKLAVNLVPFPRLHFFMVGYAPLTAIGSQSFRSLTVPELTQQMFDAKNMMAAADPRNGRYLTVAAFFRGKVSVKEVEDEMHKVQSKNSDYFVEWIPNNVQTAVCSVAPQGLDMAATFIANSTSIQELFKRVGDQFSAMFKRKAFLHWYTSEGMDELEFSEAESNMNDLVSEYQQYQEATVEDDEEVDENGDFGAPQNQDEPITENFE 457
2 -119.000[Z] KOG1375 Beta tubulin  ali follow..  73  1MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYVPRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTRRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEMYEDDEEESEAQGPK....... 450
3 -115.000[Z] KOG1376 Alpha tubulin  ali follow..  39  1MREIISIHIGQAGIQVGNSCWELYCLEHGIQPDGMMDTTVGVAHDAFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTVGKEIVDLCLDRVRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTIYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVLLDNEAIYDICRRSLDIERPTYTNLNRLISQIISSLTTSLRFDGAINVDITEFQTNLVPYPRIHFMLSSYAPVISAAKAYHEQLSVPEITNAVFEPASMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVGTIKTKRTVQFVDWCPTGFKCGINYQDLAKVQRAVCMISNNTAVAEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAEGGDDEEDEGED.................. 449
4 -109.000[Z] KOG1374 Gamma tubulin  ali follow..  32  3.SEIITLQLGQCGNQIGFEFWKRLCLEHGISPDGVLEDFATDGQDRKDVFFYQADDNHYIPRAVLIDLEPRVINNIMTSPYSKLYNQENVFLSKHGGAGNNWASGFSQGEKVQEEVFDILDREADGSDSLEGFVLCHSIAGGTGSGMGSYVLERLSERFPKKLIQTYSVFPNQEISDVVVQPYNSILTLKRLTKCADSVVVLDNTALNRIATERLHIQTPTFTQINNLVSTIMSLSTTTLRYPSYMNNNLIGLTASLIPTPQLHFLMTGYTPLMSDCETKTSKTTVLDVMRRLLQPKNMMVSAKQSRQCFVSILNIIQGEVDPSQVHKSLQRIRERKLANFIPWGPASIQVALPRSSPYAHKVSGLMMANHTGISSLFKRALAQYDKLRKRNAFLDNFRRESMFQDDLTEARDTVDCLVQEYEAATQIDYPQWSPAVEASKAG.............. 457
5 -49.200[Z] KOG2530 Members of tubulin/FtsZ family  ali follow..  15  1MREIVTIQVGEFANFVGSHFWNFQDELLGLASDPESDPIFRNHNLDMDVLYRSGETQQYTPRLVSVNLKGALGTMSSRGTLKSHYHPQSLLWMDSQAFNNYGIGKDVSEASRGEEICDRLRFFVEECDHIQGIKFLVDDSGGFS-AVAADFLENMADEYTNVPVLLYSVRTPMSSKKTVSNKLHDAISFSRLSSFCKLFTPIGPSLTGSKASKFLNLGDEKPYRSSAVYAAALHSSTIPFRMQPTSSDDVNTLVQLLTGRGRQNIVAILDSAMPAPTLAGKQLENTLLTSLQALTPEVTEDVEDNQAVESMCILGALRSEDKEALVSEVKNAVDASYEQATTKGKPLFCNLSVSRCPLVHSIPVATRWRSSSAILPFLETRMGNLEKLGIQWGAMGSDVAWGFGREELQEMRENLSKMVSELNPQFFESSDSD........................ 562
6 -11.900[D] COG0206 Cell division GTPase  ali follow..  18  13..QIKVIGCGGGGNNAVNRMILEGLKN---------------------------------VEFIAINTDKQALALSQA--------SQKIQIGDKLTKGLGAGANPEIGQKAAEESKDEISQAIKGADMV---FITAGMGGGTGTGAAPVVAEIAKSM-----ILTVGVVTKPFPFEGRKRMLHAESGIKTLKERVDTLVTIPNERLLAIVDKKTTLVE-AFKSADDVLRQGVQGISDLITIPGLVNLDFADVRTVM........................................................................................................................................................................................................ 218
7 -6.230[IOT] KOG2088 Predicted lipase/calmodulin-binding heat-shock protein  ali follow..  11  84................................................KKDYDQTEGRVTPYMIYLDHENGDVVLAIRGLNL-LLDNKLGQTKFDGGYVH--NGLLKAAMWVFEEEHVVLRELLEANPSYSLTFVGHSLGAGVVSLLVLFVIQNRVR--ERKRIRCFAIAPPRCMSLHLAVTYADVIN----------SVVLQDDFL--------RTTTALENVFKSIICLPCLLCLTCLKDTFTFEERKLKDARRLYAPGRLYHIVVRKPLRLGRYPPVVRTAVPVDVLSCNATADHAIIWIERESQRALDKIVRQKSIVEDHDEEYRAAIMKAASLNIPMSPSPSYGTFHDTEEGESSAGSGMEGSPSGWSFKGMRRKWDQFIDCHFPVNDNSEHMIFKNQESQALLCGQET........................................... 445
8 -5.190[R] COG5628 Predicted acetyltransferase  ali follow..  9  1...................................................................................................................MLNKVGTHYKIDWNMGEFFIIARF---QNKGVGRQVAKQIWQMHKRLWEVAVI-----PENKPALNDFKAF............................................................................................................................................................................................................................................................................... 63
9 -5.040[L] COG1484 DNA replication protein  ali follow..  12  96.............................................................................................................KDAFECTKEYVADYEQIKDCRKNSIALL---GQPGSG--THLLTAAANELMRTCYVPVIYFPFVEGFTDLKNDFALLEAKLNRMKQADVLFIDDLEQMYSVLNYRYLNHKPILLSSELTIEGL................................................................................................................................................................................................................................. 229
10 -4.840[S] COG1739 Uncharacterized conserved protein  ali follow..  10  17....................................................KDKGSRFIAFAYPIRTLADVLDPLKEEHHKARHWCYAYRLGVDGMQFRANDDGEPSGSA--RPILGQIDSV----GITDVLVVVVRYFGGTLLGVPG-LIHAYKEATAQALAVAEVVEKNIEKTVWLKCEYPFLNEAIRIAKQYQADIL--ERDLQLDCRLTVSLSLVNYEACVAAWKNTRQI.............................................................................................................................................................................................................................. 194
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;