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Query: [TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSQHAKRKAGSLDLSPRGLDDRQAFGQLLKEVLALDKEHELGRSNSLPSMTSELVEVLIEVGLLAFKHDDSKSEFISPKMLKEAHLSLQALMLILKRSPTVLREIKSSVTLLDWILPRTISLFADIRFIKLFDSLKEFHKLIYQLISEKSFLWDLYASFMRYWKYYITNVSSIVLQITNATFPYKMPSPNSQPLQSITPNYPTHREDKFDLLIINIEEACTFFFESAHFFAQCSYLKKSNFPSPPLFTAWTWIKPCFFNFVILLKRISIGDSQLFLHLHSRIVQTLCCFSLNFIYHGLPICEKSKHILMSSINLTLGSLKKTYTVANTAISLFFLSLFVLPKTVAGLFYPFGVSLLSDFKVLEQLEPDSDLKKAIILFKCRYQSSEIDQTTLRAFGEICTGKLENTLFSNSELNLFLLHYLSLDNDLSNILKVDFQNGHNICTFAKWCINNNLDEPSNLKHFREMLDYYSSHNVTISEDDLKNFSLVLCTHVAKVNEKTNSIFRTYEVHGCEVCNSFCLLFDERSLFKIPYHELFCALLKNPDIISSSVKQSLLLDGFFRWSQHCSNFNKESMLSLREFIMKALASTSRCLRVVAAKVLPIFIKGPNNLDIVEFHKESKALIFNTLKILAVENTAILETVILSWISLSRVVEEEELHFVLLEVISSVINSGIFYQGIGLSALQQIASTRHISVWQLLSPYWPTVSVAIVQGMGKKPNIASLFAQLMNISEGDFLIRTQAYTLPFLVLTKNKALIVRIAELSQSDVATLCLTNMHKILASLLTTDHPNLEESVMLLLSLATSDFEKVDLTSLLRSDPISITVELLQLYQNDVPHEKIENALRKVAMIVSQVVNDEDLSNKELLYDFFNNHILGILAEFSNILNDLKGKTSINEKIKTIVGIEKMLSLCGGAVKLGLPQILSNLQSAFQNEHLRFYAIKAWFSLILATKEPEYSSIAGLSLVILPPLFPYLEPQEAELVIQIFDFISSDTHKCLQGLKWAIPTSLDSACFSLKAKEIFCSLQNEDFYSELQSIIKCLTNENEPVCYLGLQKLELFFQAKVDELHDTLNLDISNEVLDQLLRCLLDCCVKYASTNMQISYLAAKNLGELGAIDPSRAKAQHIIKETVVLDNFENGEESLKFILDFMQSQLIPAFLVTTDTKAQGFLAYALQEFLKLGGFKSAVINKKKGLTVVTEHWMSLPDLSKRVLIPFLTSKYHLTPIPKIDIRYPIYKENVTIHTWMQLFSLKLMEYAHSQNAEKIFGICSKVVKDQEVNIPCFLLPFLVLNVILTESELEVNKVIEEFQLVINQPGPDGLNSVGQQRYTSFVDVFFKIVDYLNKWLRMRKKRNWDRRSAIARKENRYMSVEDATSRESSISKVESFLSRFPSKTLGIVSLNCGFHARALFYWEQHIRNATAPYAALESDYRVLQEIYAGIDDPDEIEAVSLNFHDYSFDQQLLLHENSGTWDSALSCYEIIIQKDPENKKAKIGLLNSMLQSGHYESLVLSLDSFIINDNHEYSKMLNLGIEASWRSLSIDSLKKCLSKSNLESFEAKLGSIFYQYLRKDSFAELTERLQPLYVDAATAIANTGAHSAYDCYDILSKLHAINDFSRIAETDGIVSDNLDIVLRRRLSQVAPYGKFKHQILSTHLVGYEKFENTKKTAEIYLEIARISRKNGQFQRAFNAILKAMDLDKPLATIEHAQWWWHQGQHRKAISELNFSLNNNMFDLVDEHEERPKNRKETLGNPLKGKVFLKLTKWLGKAGQLGLKDLETYYHKAVEIYSECENTHYYLGHHRVLMYEEEQKLPVNEQSERFLSGELVTRIINEFGRSLYYGTNHIYESMPKLLTLWLDFGAEELRLSKDDGEKYFREHIISSRKKSLELMNSNVCRLSMKIPQYFFLVALSQMISRVCHPNNKVYKILEHIIANVVASYPGETLWQLMATIKSTSQKRSLRGKSILNVLHSRKLSMSSKVDIKALSQSAILITEKLINLCNTRINSKSVLast
1 -302.000[TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family  ali  100  1MSQHAKRKAGSLDLSPRGLDDRQAFGQLLKEVLALDKEHELGRSNSLPSMTSELVEVLIEVGLLAFKHDDSKSEFISPKMLKEAHLSLQALMLILKRSPTVLREIKSSVTLLDWILPRTISLFADIRFIKLFDSLKEFHKLIYQLISEKSFLWDLYASFMRYWKYYITNVSSIVLQITNATFPYKMPSPNSQPLQSITPNYPTHREDKFDLLIINIEEACTFFFESAHFFAQCSYLKKSNFPSPPLFTAWTWIKPCFFNFVILLKRISIGDSQLFLHLHSRIVQTLCCFSLNFIYHGLPICEKSKHILMSSINLTLGSLKKTYTVANTAISLFFLSLFVLPKTVAGLFYPFGVSLLSDFKVLEQLEPDSDLKKAIILFKCRYQSSEIDQTTLRAFGEICTGKLENTLFSNSELNLFLLHYLSLDNDLSNILKVDFQNGHNICTFAKWCINNNLDEPSNLKHFREMLDYYSSHNVTISEDDLKNFSLVLCTHVAKVNEKTNSIFRTYEVHGCEVCNSFCLLFDERSLFKIPYHELFCALLKNPDIISSSVKQSLLLDGFFRWSQHCSNFNKESMLSLREFIMKALASTSRCLRVVAAKVLPIFIKGPNNLDIVEFHKESKALIFNTLKILAVENTAILETVILSWISLSRVVEEEELHFVLLEVISSVINSGIFYQGIGLSALQQIASTRHISVWQLLSPYWPTVSVAIVQGMGKKPNIASLFAQLMNISEGDFLIRTQAYTLPFLVLTKNKALIVRIAELSQSDVATLCLTNMHKILASLLTTDHPNLEESVMLLLSLATSDFEKVDLTSLLRSDPISITVELLQLYQNDVPHEKIENALRKVAMIVSQVVNDEDLSNKELLYDFFNNHILGILAEFSNILNDLKGKTSINEKIKTIVGIEKMLSLCGGAVKLGLPQILSNLQSAFQNEHLRFYAIKAWFSLILATKEPEYSSIAGLSLVILPPLFPYLEPQEAELVIQIFDFISSDTHKCLQGLKWAIPTSLDSACFSLKAKEIFCSLQNEDFYSELQSIIKCLTNENEPVCYLGLQKLELFFQAKVDELHDTLNLDISNEVLDQLLRCLLDCCVKYASTNMQISYLAAKNLGELGAIDPSRAKAQHIIKETVVLDNFENGEESLKFILDFMQSQLIPAFLVTTDTKAQGFLAYALQEFLKLGGFKSAVINKKKGLTVVTEHWMSLPDLSKRVLIPFLTSKYHLTPIPKIDIRYPIYKENVTIHTWMQLFSLKLMEYAHSQNAEKIFGICSKVVKDQEVNIPCFLLPFLVLNVILTESELEVNKVIEEFQLVINQPGPDGLNSVGQQRYTSFVDVFFKIVDYLNKWLRMRKKRNWDRRSAIARKENRYMSVEDATSRESSISKVESFLSRFPSKTLGIVSLNCGFHARALFYWEQHIRNATAPYAALESDYRVLQEIYAGIDDPDEIEAVSLNFHDYSFDQQLLLHENSGTWDSALSCYEIIIQKDPENKKAKIGLLNSMLQSGHYESLVLSLDSFIINDNHEYSKMLNLGIEASWRSLSIDSLKKCLSKSNLESFEAKLGSIFYQYLRKDSFAELTERLQPLYVDAATAIANTGAHSAYDCYDILSKLHAINDFSRIAETDGIVSDNLDIVLRRRLSQVAPYGKFKHQILSTHLVGYEKFENTKKTAEIYLEIARISRKNGQFQRAFNAILKAMDLDKPLATIEHAQWWWHQGQHRKAISELNFSLNNNMFDLVDEHEERPKNRKETLGNPLKGKVFLKLTKWLGKAGQLGLKDLETYYHKAVEIYSECENTHYYLGHHRVLMYEEEQKLPVNEQSERFLSGELVTRIINEFGRSLYYGTNHIYESMPKLLTLWLDFGAEELRLSKDDGEKYFREHIISSRKKSLELMNSNVCRLSMKIPQYFFLVALSQMISRVCHPNNKVYKILEHIIANVVASYPGETLWQLMATIKSTSQKRSLRGKSILNVLHSRKLSMSSKVDIKALSQSAILITEKLINLCNTRINSKSV 1999
2 -24.300[A] COG5181 U2 snRNP spliceosome subunit  ali follow..  457...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................KILVVIEPLLIDEDYYARAEGREIISNLA--LAHMIATMRPDIDHVDEYVRNTTARAFSVVASA-----LGVPALLPFLKAVCRSKKSWQARHTGVRIIQQIALLLGCSILPHLKNLVDCIGHGLEDEQQKVRIMTALSLSALAEAATPYG----IEAFDSVLKPLWSGVQRHRGKSLAAFLKATGFIIPLMEPEYTRRIMKILLREFNSPDEEMKKIVLKVVSQCASTDGVTPEYLRTDVLPEFFHCFWSRRMASDR--RSYKQVVETTVVLAQQVGSRQIVERVVNNFKDETAETVDKVIGSLGVSEIDERLEELLLDGVFQEQSVEEKVILTCFSTVVN-----ALGTRCKPYLPQIVSTILYRLNNKSAREQAADLVSSITIVLKACGEEA------------------LMRKLGVVLYEYLGEEYPEVLGSILGAIKAIVSVVGSSMQPPIRDLLPRLTPILRNRHVQENTIDLVGKIADRGSEYVSAREWMRICFELIDMLKAHKKSIRRAAVNTFGYISKAGPQDVLATLLNNLKVQERQNRVCTTVAIAIVAETCMPFTVVPALMADYRTPEMNVQNGVLKSLAFMFEY---------IGEQARDYVYAITPLLADAL---MDRDAVHRQTAASVIKHLSLG----------------------VGLGVEDAMIHLLNILWPNI-LEESPHVINAVREGIDGIRNCIGVGPIMHPSRKVRNTYWTSYNSAYVQSADAMVPYYPH.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 1170
3 -21.000[S] COG5543 Uncharacterized conserved protein  ali follow..  38.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EDWYLKNGLFFRYYSFLKSSENATLDGPSQVACLDTISVWLRRIFNMELKFWTNLFSLPANKISIPLTGVQVAVKDVFSKSLQYLLVCPSEDIKNDFLLDSLKHALHWDRHAKVVCTAIQLLVKVTGAEAVFAFQPDFFEQSLKLLKDYS-------------YAQAISSTILTVLTLRFKSLSEETEDREEVETK-CPIILYEFYGNDRQVQAGMSSFLIPSLL-GVSPGITVKFLSRLQNYPNVSKDARDAACLYAL-------KIAKDSKIIKNLDLVKEHAFVKTLFKHPDIKIQLACFRLIALCPNVSSPLSFFDCLESNIEFSFNVLDPDSRQILLKSMQDFFIRLRASCHSIARTMRSRHSDKVALS------GLLDRAMQFLTSFISVCKKHLYPTCNYQQ-VLVSLSFLDTLISFGLDDNVES--RDLSRLMIDRLKDPYDDIRNLCLKILLSYKSLPGFISDSDAYFL--------FNHGLELLNAVRECDGGAKTIYLCNHFMEKSVPGSVLANTKVILNRLKSNIEHAKTSLLEAAVNCPLQGYLIQLTYIFQSLSNDNESWKNIVMELIKASETIWGLIKDVLCDDSPEGNLPDGEGEGGIVSNLEDTPAQLILSSWRSLKE------TSSLLTVLLTKCLSLFDEEFTP----------FTLNYYGELMMTWLWEIRFTSVYPCFIEYCSFLFECNKH-DPWLHKNLSVIQEKSSFITRRSG-------------------IPLSITAILVAGKDKREQLIEQTVISLISIAKQPVEQKNIAGQFDLPQVHAMNTLKTI--------------------------------TEHRLSSVSVEYLEPA--IALSIEGFSHELWPRSVM-------------------------LFTAL---NRAFGSKKPKDAVNLSTKMFFSKFPTLHDYLLRELEVSVASLSSNDQPSTGLYPILNMFSRLQAQPYGNENEWTGLSQFEPLIFKCTASRICKVRE-------------------ASLSLTCLLDCSKMTTFIVSQ----------LKGVAGLQQNEIHGKLLTIRAVLS-CFFSKLTLQQVQEFYEVVPLAFINCFLEFTSSKTSFYAKKLFLEVLNSYFMSNTDSNAKRLQQLRRMTMDYCKRMLLDRKANVTNVFNTIGLPIH----QQMAATIFLENLKEFSVYCDAHSIGFLVSKLLHYEFYEVQLTTLRSIVDSPRKKIIVNNPEILQALIKLTPRNQWSQSLLSDSLNSTSYRLLGISCSDMVSNILSNECLPIKESFIVLLGSCIKQLKTENFLEYKVTFAKWVEILLSYSNEYQPFSSRKAAL-------DSIIHFDLFNAESTAEAFSFEFYILYLLLGDFLNDDDEEIRSLAANHAYQVLGT-VTEIWNLWKLRTKATFGGQHDFQHCINKRLILEDGCELASVQLDNALSRNCSLFER.............. 1407
4 -20.100[YU] KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily)  ali follow..  6......................................................................................................................................................................................................................................................................................................................................................................................................................................................................DQHELEQVIQLLQHAHSTDRDVQRNVQVQLVQL--------------------------------------NEHQKFCCYLVYILSDMKEMIDATSRSLAGLLLKNNIAKWNKYPQDVKFFVRTTCLKSIGDQEPLIRATVGIIVTTIVMEENMCD---------DLLDTLATVLMQPDELMQEGALGALQKVFEDSADRYLRPIMPKLLVFYEHHAAKMRALAMNCVNCILMVNNDPIDFAIDQFLTSLFARHNDN---QKQLCRSLTLLLD-THIEKMMPHLPNVIEYIIKKTQDEFWLSIAENSDICRTMV-LPHLDKLIPVLLSMRYSETDPALKANDEDSSVPDREEDIKPRFHKSKQHGLGGLVESDDEEDEDDD-----------DGGGDWNIRRCSAASLDVLASIFGKDLLDKLFPLLKDTLMNDNWLVKESGILALGAIAEGCMDGVVPHLGELIPFMLAMMFDKKVRSITCWTLSRYSSHIASDE-QQFFKDVLANLLRCSLDGNKKVQEAACSAFATLEEEAGEQLIPFLGEI----------------------------LDQLVKAFQCYQAKNLLILYDAIGTLANSVGD-------ALSHPVYVQMLMPPLMEKWER-LSDEDKELFPLLECISAIVSAMGQSFLPYIQPVFTRCCSLIEKCVQQNQLVANSKLVELMLFCSLDVTPDVRQSCFALLGDLTKACP---------------ERVLPQSSNFIFFLAQNLDPSKISVCNNAIWALGELALKMGPAMKQFIGPIIEPLIVVINSQQLENTAITIGRLGQCCGEELAPHFVRPCCYSLRNIKDNAEKESAFIGLCNMINMNPVG------------VLNDFIFWCDAIASWTVPTDSLRVLFAGILQSFKQQVGDFNWNNFILQLPPPLRERLSAF......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 880
5 -19.200[O] COG5021 Ubiquitin-protein ligase  ali follow..  324.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YAFNSLTDLISLSETKIPKELRTDALFTLECISLKHVWCSDIIRNQILRYIAKTLREATDEIDEEYNVRFFYLISNLADVKPLHESLFAAGLIPTLLEIVSIRNCHLLETFIDNSETTTEFIENDGFTMLITSVANEIDFTLAHPETWQPPKYSVVYYSISFRELAYIRSLLKLVLKLLIRNLIDSP-ILVSLKKILE-NKLVFGLTLITYTLDVVVINSEPTIYPVLAGLIPYVIDNFLLSLLPDVVSAICLNPEGLKQVKEKGLINNLFDFLLDTDIDELLKANIVEALCNVIRKMPSSPKDQKYFFHRKNEEILTDKEEHEPAYWELLDKGTMLDT----FTSVLFGMSLGNGSFSQVPQHSVAISNVTEVLQYLDEK-DYAFMDVMKVLNDQLENLNDFLNSPNDRSFFLERDGENSVRSCHSKLLAAILNIVTNVYIDLTTLSCKRIMQIYSYFDKRGFSLIKNLKLLEEMYIRQHMPDSVITETMPLPIVDVSGDGPPLQIYIDDPKKGDQKGKITSVKTRNTLQMRTILYT--LQSNTAILFRCFLRLSHRNMDLEHKDLTTEVHIFENVVENVIEMLKATELEGHLNFNTFVFTIPKASPNSTEILQTIPAYIFYQKGGYLLYLHIIRDLFTRMTKIKDLSSLDNINYIDESNGILTLSCLINALTFYNKSMQTETMENVQSIGKYYVSIDDDYNIMKALTVPIKVMALAMILD------LDKSDSLFKTQSRNVPYSVFKQLMLKNIFTNVNIYTKELIKKISLFEQVGIPGDVAANYLTDTGDDLPADNSIG------FSPEQWEKYKKLIGEDKSIYYPQPMQAQYYKGCSSKELDELRDTFFNDGLPSRIFTVLPFYPKLVN-KTLLQIFTKYDEPTEVFAGRILDRILETDDDPATLSSLIHLFGIFLNEKYIYQKASHLMQRFIEYLEKSLKPEHVNTPWFSKALYVYEII---LPHLEELSKDVLLRYPLLSMAKVFRIPDPMKQKLFDILIRVSDISNFYSA-LATSRILIFYSRDELYANNSGILSRLLKVIGSFQKLDKINFLESSFLLLTR-RCFETTENVDALIRAEINRSFTARPLG----GGDDAVRELTTILEEKAHVVMRSPSQFIDVLCETARFHEFDDQGALVDYSLKRFLGEKDKNTQASSTE---DIYERTGIMHLLLSQLMAASEKDWLSEPANSSDLPENKKAQLDPSPVCAYMIFLLKL-----VELVSSYNQCKFEFLTFSR----INFFLYRLLDKPVGTDHDKHEAKR------REVIGMLARSV-------------IIGF----ATVQDDRTTKTDVKLADPHMNFIRKFAIEAIIKAIRNATSSSKLHLKLDMWFRIITSMVYVDLGLPSVITEAMASIDLNYPF------------------------------------SKKIFNVAVEALNTISSTRNNFSEHFKIEDHD 1881
6 -18.600[S] KOG0212 Uncharacterized conserved protein  ali follow..  11  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MDNLLVRGLTHKLYDKRKATAYELERVVKGYLENDETEKIRAVISQLANDFVYSPARGPNATFGGLIGLAAVAIALGPKIMESILLPVLYCFNDSDSKIRYYACESMYNIGKVAKGE----VFRYFNLIFDVLCKLFADTEITVKNGAELLDRLIKDIVMQQAATYMSSAEDIKNFKE-VPVMSTEQPRMHTFSLSELVPLLSERLYVINPNTRMFLVSWIRLLDSIPDLE-----FISYLPFLLDGLMNYLSDPNESIR-IVTSNCLYDFLREIQKIAKVKYHILQRDEES-----EPDFFDSMVRRNMSDAELKEISDYVESLRDGSFILEAHIQIDYKRILEIIIDHLGSSVIQEKALKWLFEFIY-IAPKDVLLQIPKVLENLLPLMSN-DENMRQSAKDLSQNLVILVSKIMDI------------EFSGSETNNKDNSLSVDFRSLIEVLQKLLSNDNEETRLCALEWVLLLQRRTGGKLINM---------HDPIFQTLLLQL---SDPSDLVVSRTLELLAHI-------------------------AISHKSVNLVPFLKSLLQMF-AEDRKFLNSRGNLIIRQLCNYIEGERVYTSFAGILETEENL--ELASIMVEVLNNNLFTAPELYDKQSAPKLQNIFTT---YTAWCHN-AANLLSVFAEIEFNDMLIQLDKLVQLIESPVFTYM-PYLH--LMLLPQSSAFRTLRDRLQCSSTPRTNTILANERLPRSRRDDPYWTDLLERLKAVQLSHQNNYREPIRATRLALAGALPSTPTATTIST.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 773
7 -18.300[A] KOG0495 HAT repeat protein  ali follow..  1.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MSNITAAVIANRNKKHFLGVPAPLGYVAGVGR-GAIGPAR-PATKRKKKDEEEEEDEDLNDSNYDEFSGYSGSLFSKDPYDKDDEEADAIYDSIDKRMDEKRKEYRDRRLREDLERYRQERPKIQQQFSDLKRSL---------------------ASVTSEEWS-----TIPEVGDSRNRKQRNPRAEKFTPLPD-------------SLISRNLGGESSSTLDPSSGLASMVPGVATPGMLTPTGDLDLRKIGQARNTLMNVKLSQVSDSVTGQTVVDPKGYLTDLQSMIPTYGGDINDIKKARLLLKSVRSARLEEVTGKVQMARNLIMRGCEMNIQSED--------LWLEAARLQPPDTAKAVIAQAARHIPTS-IKAADLESETKAKRRVFRKALEHIPNSVRLWKAAVEILLSRAVECCNTSVLNKARENIPTDRQIWTTAA-KLEEANGNIHMVEKIIDRSLTSLTVNGVEINRDQWFQEAIEAEKSGAVNCCQSIVKAVIGIGRKQTWIDDAEFCAKENAFECARAVYAHALQIFPSKKSIW-LRAAYFEKNHGTRESLEALLQRAVAHCPKSEIL---WLMGAKSKWMAGDVPAARGILSLAFQANSEDIWLAAVKLESENSEYERARRLLAKARGRLEWALEKFDEALRLLEEAVEVFPDFPKLWMMKGQIEEQQR--RTDDAAATYTLGLKKCPTSIPLWILSANLEERILERGRLRNPKVAVRVELRAGLKEIASTMMARAL--------QECPNAGELWAEASVDALKKCEHDPHVLLAVSKLFWSEHKFSKCRDWFNRTVKIDPDLG-WAYFYKFELLHGTEAQQ-----QEVLDRCISAEPTHGSWCRVSKNIQNWQFKTPEVLRAVVRELS...................................... 910
8 -17.900[YU] KOG1241 Karyopherin (importin) beta 1  ali follow..  2...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TSDIAMQLIAILEKTVS-----PDKNELLSAKNFLEQAAAS-------NLPEFLKALSEILVNTANSARMAAGLQLK--------------------------NHLTSKDEKVSQQYQDRWHQF----PSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIELPINRWPMLIQTLVNKVVSEGSSEMHRESALEAIGYICQDIRFGVMENQSNDVLTAIIHGMRKVATTALHNSLEFTKSNFEKDMIMEVVCEATQCQDSQICVAALQCLVKIMTLY-----YQYMEPYMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQERVSKHYARGALQFLTPVLVEKLTKQDECDDEDTAKAASVCLMVLATCCEDEI---VPHVLPFIKENIESPNFRDAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRIC---------------------------DIIPEAAINETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEAAVTNDGETPETYALSYIITQLLETTDRSDGAQANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMET--------QINNHSDRHQFNDLQSLLCATLQSVLRKVH-----------EQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAQFAKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYS-------------NEIMTVLINNLT--EPTIHRTVKPQVLSAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYINELRESILEAYTGIIQGLKGQTAHTDVMHMEPHLMHIIFIKRIAQEGDVSDSMLASAAGFIGDLCTSFGP--RLYPLLDDAIITQFLAEGKRSKAQRTKMLCTWAVKEIKKINTQVIT..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 883
9 -17.700[R] COG5307 SEC7 domain proteins  ali follow..  124..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ASLEKQKSGLTNLEKSTHVVLIKCIEQLIQIKVCMKNEKMKNLMEQLKPLLQTECQFDKFLIVELFQYCFESSQDEVMNISLDTISKLASFAYFSSKDKTPAS------------FGPPKSLLQCMVDMVCDNDEVVDGNLQLNVVKALSAFILCSEQDSM---------------LHGAILLN-------------------SVRKLFNVFLLGDSDTIQSVAQASLTQAV----TVVYERLRASHTQSNSTSALPEEDASVTENWVHDEDEPDKKITLHSMASAGTSSLDHVKVDADDPAVTSVENSSI--------QDAFLVFRSMCRLAVRQTSPDKVSNIRSQAMRAKLISLHLIYRILEKNSDLFMDPTLQFRGIPALKGMTLVHASRQYICLVLSRNAVS-----PVPQVFEVCCDIFYLMVFSLRAHEIEVFFREVYFPMLD--KNTSYNQKLHTLLIIQRICLNPRALVELYIN-LFSISKVTTNGPSETISEDIEEILPSLESSERSSTPFLNTNSALKLKTLQCVLDILQSLSNWAESGLSSSIALADPSQF-KLLRTCINKFNYKPTRLKMLSEN--EYVDINDPKAI---------------------AEFLFR-IDKTTLGDYLGEGDEKSIS----VMHEFIDCLSFINL----------------KFVDALRRLLQCF---------------RLP----------------AQKIDRIMLKFSERYMKENPSAFANAD---TAYILAYSI---ILLNTDLHSPRIKNKMTK--DFIKNNRGINDGADLDEDYLGFVYDDI---------LKNEIAMKDDQELAAIAPLMNNFSTSSGFTTFTSNGRDLQRVACIQASEEMANKATSVLKKLLYQQKHGSQKTNVYYNATHFEHIGPMLEATWMP--LAALSNPLQNSD-YVNELNMCLDGFQLVVRIACLFDLDLIRDA------FIKTLTNF----TNLHSTSEIKLRNTMVIKTLLRIALKDSWQLERVQLIGVGVDETEVPDVINARVRRKNVNIGSSNSIRHVSGSTSRSTRTRSLSKPLSPEAVSELMSTEVVLSIDRIFTQTSSLSGSAIVSFFKAL-SWDEITSSSDLEQPRLYSLQKLVEISYYNMQRIRVEWFNMVGSDENRHVAVFALDSLRQLSMH-----FLEIEELSLFSFQKEFLKPFEYVMASDTVVEVKELVLQCVKQMIQAKISKIKSGWKTLFGVFTFAAKARSEILISMTFDTLVNLFSEHYDTLMQQNCLIDMLISFTELCKNGTNQKISLQSEIIREVYSSLSTMIKEGLSSKPSVNETFSKYVFPVLFAYYDIIMSAEDLEVR-------SRALQNLFYIFLEESDDFTEETWEVVSRKFIFPIFSI-STTLVEALRSLVTLLTRR--HNLLLFSNCICRDNITLSRIGTNCMQQLLSGNAYRFEVKDWNLVADMFIELFKETTP........... 1564
10 -17.700[U] COG5215 Karyopherin (importin) beta  ali follow..  6......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FAQLLENSILSPDQNIRLTSETQLKKLSND-------NFLQFAGLSSQVLIDENTKGRILAALTLKNELVSKDSVKTQQFAQRKNQIKTNALTALVSIEPRIANAAAQLIAAIADIEPHGAWPELMKIMVDNTGAEQPNVKRASLLALGYMCESADPQSQALVSSSNNILIAIVQGAQSTETSK---------------------------VRLAALNALADSLIFIKNNMER-ERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMS-----LYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEE--EIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLQNEDPEDDDWNVSMSAGACLQLFAQNCNHILEPVLEFVEQNITADNNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDP---------------------------QQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEATPSPIY-----NFYPALVDGLIGAANR-IDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDE-VADMLMGLFFRLLEKKDSAFIEDDVFYAISALAASLG-------------------KGFEKYLETFSPYLLKALNQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLNPNARRELKPAVLSVFGDIASNIGADFIPYL-------------NDIMALCVAAQNTKPENGTLEALDKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQ--DWVIDY--IKRTRSGQLFSQATKDTARWAREQQKRQL-------SL.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 861
11 -17.000[A] KOG2047 mRNA splicing factor  ali follow..  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAISKDLYPSQEDLLYEEELLRNQFSLKLWWR--YLIAKAESPFKKRFIIYERALKALPGSY----KLWYAYLRERLDIVRNLPVTHPQYDSLNNTFE-------------------RGLVTMHKMPRIWVMYLQTLTVQQLITRTRRT------------------FDRALCALPVTQHDRI------WEPYLVFVSQNGIPIETSLRVYRRYLMYFIEFLVKSERWQESAERLASVLNDDKFYSIKGKTKHKLWLNVDAIIRGGIRKFTDEGMLWTSLADYYIRKNLLEKARDIYEEGMMKVVT---------VRDFSVI--FDVYSRFEESTVAKKMEMMSSSDEEDENEENGVEDDEEDVRLNFNLSVKELQRKILNGFWLNDDNDVDLR-LARLEELMNRRPALANSVLEQWHRRVKIFEGNAAKQILTYTEAVRTVDPMKAVGKPHTLWVAFAKLYENHKDLVNTRVIFDKAVQVHLASVWCEWAEMELRHKNFKGALELMRRATAVPTVEVRRRVAADGNEPVQMK----LHRSLRLWSFYVDEESLGTLESTRAVYEKILDLRIATPQIIMNYAFLLEEN-------------------KYFEDAFKVYERGVKI-------KYPHVKDIWVTY---------------LTKFVKRYGKTKLERARELFEHAVSMAPSDAVRTLYLQYAK---EEDYGLAKRAMKVYEEATKKVPEGQMYEIY-ISRAAEIFGVPRTREIYEQAIESGLPHKDVKIM---IDRARALYKYSSQFADPRSDPE.. 734
12 -16.900[R] COG5219 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  31.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DESSSNFSTIYEPPDLSGLDAEMIVIVKNLQKRDIVTKCRALQDLIQWNDPSQFDNEQFLNALAVLFPRLSIEVERHVRLKIFVFMSVLSSALQKKLAPWLKFYITPWVMGF--DSDRAVSVSAKDSFKNLL---------------SEEKWPHVWLKFG-----------STIAPIVTDVFLHEDKESLTDLRFFSNKSSCLLTLSFLFKQTADLENLETDKKIDKQLYENLSTLFK--SDEFWSLVSSPQDGVTVSLSDLLLIILKYDKPFVTQYKEKYFKRVSRMISRLT-SLTCVPMLRLLSNMISKRPLSKLFSNLITSLLNLFKSIGAMQLVPSIESVDELCFLSTEVYDCLLNFLSFVYTDSSDPQFTRYFKGEFVLRCSTSDFDHCLQSVFDKNSDFASLWNEVLFGFFNDESMDIETIPTGNEVMSILGPCLSFLMKLSTHKNERIACLSASQLITVCHIFSDTTELFQKYLVNDLPSSILKLGPQSPAFTLLRDILSEPWENVANQFTVSFDELENIRVLNSLPSLFADGKLRGKISLVKTLVEYYDTAVFAIMQDMIRACIGSK--------------ILVPEETIKNILFTTLEYFLTNDWVDNHLIILCASLHSLKAHLPTIFDENKSLYSLLPVILFSKPEDDGHVAAHFESIFSLLKEKALEDSGFSLKLCSEVQEWSLNKVLN-GSINEKLAADKCVLVFNSFGKLPSNFFTFPASFWDAKISSCIPFFSNKLFIDVGTQFVHIFHASLYTLYYVETTGCDGIFVESFECYFKGEVVKFAENTTSFSIFAAQGLTDFLIVVSNLLEMDE-KHVDVVLGKLGLSSSKSPIFVSSILEGLKPL---FKAVNDLTGKLHSANEVSKSLLILNAATT-NITNW--CSESGIKSLELLPVCCFLRFMYYFLPTVF-SLSGSYWNSIFDYIKYAMKMSVVDAPIVKSFELFALRLYNALSKNYEMN----SDIKDCIVESNE------SMNYLLLKRFLFTHESTLRNSVTARMCNQYVKLLENCPGKVVRSFQYQEPSLCNSNDLQMESV-----------CMKFLREKLSHELKELTVYYMVESDYEPDVSLCPELLSLAIYLLVWD-YHFEETTYNIKLSIINQLHAMD-------LLRPLLNTLVEILNLSYDRPMDYSSATDRIRCLAIHIYYQCL--------RHLSSSVRSYW----------SEVKNRAFTSTVESFTGYNVSPL--LISASLDDVERSI-----GDVNVKVNRNTREISFIYNEMAIKIPSVYPLQNVWIL-----ASQSILSSQNGSITDALLVLKKNISMHFE--SVLSVERTLPNKRCGTCRHKSSNSSR 1599
13 -16.700[DK] COG5103 Cell division control protein, negative regulator of transcription  ali follow..  365....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LSIISHIILSPTSMFDIREFNVNPVVSV------DSLKDYSEELVNYAKIYEKSNLNCIELVQILLRLLSEVVTYETSLFLNFLDEKVSAELLLLGTLQ-LPLAWNPVQESLAFQWCSDFFSNFKEHKF--VFVRIERTNPQFLFAFLRSLWLKDSSSV-NQVVEFIIENDFTSHIGNINRFALEIAALAAARKALSFQDWLDKKMLEFLVEVLDFLMSRAALQKNESEQKEESVVLDTVNVLLTTLMDNISEEVSEHIKDVQILCLQPDVESEV----ESYFQALYERRIS--IGKIVLTLQNFKKSENPRDLDLFACLQHSLFDEYRFFPDYPLEALALTAVL------SLIQFELLSFVPLGVALRYVYQALLMPTDSFGMQALVQFQEKLPKYINYCNLILGIPSLQLVRPDIYDSIREMIASNENTEVE-ESVCDNILFAINNLSQLNFNEKLKDVKDNLTPAYLP------FSHYIVTQRV------SREANFLSLYGKFLEEL------------------KSSDLYKIVFRDTLQAILDIMNNNAETLSPSEKTN--------KNLGSWL-----SITLLRNKPITTLQVSFKDLLLEGIDSGRIDRVLPFVC-KVLEKASSSVI------LMGILKLLVELYQFADFRLNLKFEIELLLNNLN--SEMYRNHLVQKADLEKELPEDVLNAEFPDGTDVITQY-LIIQQSVLEIISAVVRRSVGIAAITTKSLLQKDFAAESNPSRLLAARQMAKTLAGNLAMVTCREPLQ--------MLMINNFRTIALQDVENVHAAVAQAIDELVSQNLFVASSVIESVASETAIAEIDAEIEHMIVERVRHRKTTPNLPFVDP-QFQLYENFDRLSLSTIMSNNSFTSLNGLRTDSADSTALNYARNLLIIIGQLFQLAAQMPYTSMQEVPADHELHELVNQFLTGVASINHPIADCAQECCRILLTDSKSPFILEVFSAILEYICQASTKTAINVSLYWNFSNDLEKLN---PIILSLIRFGILTSGEVDYHVARGVRSEQGSGPVTDFAIELLRTAVGGENPMALPGNSESFSGETKQAYEQLVETMNKSVSPASEILSDQIIIVFVSWVHLLRNSATNDETKAAFVYQLHK--QGILSEPELCIQFFRCNLEAVLVAFLEAASVNAPDYFDAYASLLVNVVKYTEGSTEGTVSSKSVLFR--------KIIALIIGVFAELHNSVHQKTFFRLFSSILSELDDAKDVLESCFVDIYSVILRSFPAFTFWLLPKVLLVNNDKINDLFSEILMSFLKDLKDDIDKAQFKLLYNGFLRIILVLLH........... 1823
14 -16.600[B] KOG1156 N-terminal acetyltransferase  ali follow..  10  17...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ILRCYEHKQYRNGLKFCKQILSNPKFAEHG--ETLAMKGLTLNCLGKKEEAYELVRRGLRNDLKSHVLLQRSDKKYDEAIKCYRNALKWDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPAQRASWIGYAI-AYHLLEDYEMAAKILEQTSPDKVDYEYSELLLVLREAGLYREALEHLCTYEKQICDKLAVCRLEDAADVYRGLQERNRLKIYEEAWTKYPRGIEELVVGYETSLKSCRLF-QPSIALEYINTAI----ESTPTLIELFLVKAKIYKHAGNIKEAARWMDEAQALDTADRFIKCAKYMLKANLIKEAEEMCSKFTREGTSAVENLNEMQCM-------QTECAQAYKAMNKF---------GEALKKCHEIERHFIEITDDQFDFHTYC-----------------------MRKITLRSYVDLLKLQHPFYFKAARIAIEIYLKLDKELKKLRNKQRRAQKKAQIEEEKKNAEKEKQQRNQKKKKD-PLEEAIKFLTPLKNEIYFRKEKFLLMLQSVAFAIDSSHPHECMIRLFNTAVCESKDLSDTVRTVLKQEMNRLFGATNPKNFETFLKRNSDSLPHRLSAAK........ 770
15 -15.800[K] COG5221 Dopey and related predicted leucine zipper transcription factors  ali follow..  9...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TIDSNNKQLDSKQKKFRANVERALERFDSVTEWADYIASLGTLLKALQSWSPKFQNVRYQVSRRLTSSLSPA---VHQKTLEVYTYIFEH----GLETLATECNIWIPGILPLMTYASMSVRSHLIELYDNLPQTTLRLLIRPLISSLLPGIDDESNDFLPLTLKLIETLQENLDDDSL-----FWQTLFLVMTANKGRRLGGLTWLTRKFP-KRKEEAFKVLLPAAKDLVTPEPGLLIRCLVGCLEDENDILIKRSVLDLLLQRLRLDSPVLNVLITS---EDKKLLIMSCCRTTLSKDM-SLNRRIWNWLLGPTAGGMLNNN-----GGNSMEYTTSVKSANEESNVYFTKYGLSAL--LEGLSDLLSEEESVLTAFRISMAVMDRWEIGSLVIPELFIPLLYSSEKFKQNEQIMKTA--IWGKLFQELDEEIIVRHLPLILLTLLALPSNDKDFDNSLYNKLLNYI-EVSCEELLAKIRGFYTNVSNPSSILEKENIAERLPPFTTEDLTFLIADLIQKWDLENINESSKLFIAIFEKIPES-EELKGRSHISWSDKKITQSIFEAIPRLCESNNDAKSEEIVGI------------VEIFGNYLYSRMEFIESMKLLKVVMMAVWKSLVKNLKTLNRFIPSKFIESALVYTFV------EEEDISERLSVLDLLWTQLDSDSNLIRRPLELILGELFDDQN--------PFYLTVSKWILSILNRLFYILTDNILKVNRLEKERLDERDDLDMLTYEF--MLAYVLKTNNGRTRKVFSTELTSIKSSTIWKNEDNIKSNTHAKSIRSALILLDILLDGTEQNFKDIVIFLLQMSSKYIAEEGIEPELIAVSLLDIVSKVLRLSHDNGIKLDIFDDNAAHLKYIDFLVTSVSNMKSPLIVTAYVKLLSESIVYFENS-PLSASLVQCVQRLFLLEKREGGYYQPIALLLGGLEELLEISHGYLVTEEREGYFSGSNLKGDFIQSVVSNVFSSDSSNEESKIQGEISCCLDI--WYWAHNISCKSNDDSFKFRSKKLLETLFLLEPLELLENLISIRSDNTTVTLVHVLDGNKPAI-HLLYGVIIRYNRTASVKFSNRDGSRSSTTKLTKGEPSMLKRLSGESIIAFLFNYVDSVE-NSAMEEFYGDFLLFFREVATNYNLYSDVS-LKLVALISGKVSKTQFGEQKRVRREISDVFFKYLPNAFINFTNLYRGHPQIGGDKFNTTLATIVNQCLTPYIKPKSEKTIPELAAVVSHLGSKVKSWRLLIAEL--FQNDKKLSVIGSDQT------------EKIIYEWSIYPENKSKILNDLLLEIGS------KRSSVTPTLITFNLGSDSEVEYKCQNLLKISYLL-------PNDAYLLHFSSLISCIFH-KGSCWILLRVLLLRFSESH--NDYWSMI-----------YCLQTNLQEFYESLQIQSEVD---QTILQVCKTLDLLLLL.......... 1589
16 -15.800[OZ] COG5234 Beta-tubulin folding cofactor D  ali follow..  18...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ITSRLSQILDDVLDDRSSSHSVEKLKDVAVKY------------LQFCQFQPTLLDKLLSKYVPNLASYLLKVKNIGKCNSITVILYQFKAVRVLFPVGVQYI-KELYTLLNESSNNTWHFHYIVLLWLSQALNTSLDDSLDVKKTIYTIAIKYLEN-SGIDKEASCLVLSRLFSRDDHHCESSWFKRSIFYKIGCLFSLSSFLKICPRNDVAFQFLNVAREDLVGQENSALRKLLCKCYTRLNPDSFFQLPDDSNEEVHIYLEVIVDFLLSSV---SDIDSFVRWSAAKGLAKI-----SRLPWNLAEQ---------------------VIDAIIELMTSITSPLVWHGAILFFAKLAG----------------------GLIKYSKCLHILPLIEVGLSYEVRYGTRVTGQSIRDASCYFVW-------------------------SFYHCYSKSAIEGLQTNLILCLLQTVLFDNEINVRRAATAALFEVIGRHASIPD---------SLISHINYVS-----------------------TDISNCYGDLCMKVAHFPQFRSCVFQRLF-----------TNLQHWDVKVQQLSAFIKYPKELSIYLPPILDYLSVGNYTIGLASIIGGFLSISFPFDINRIHDLLSHKNLLSLKKFSRQQQTKIILGILKGIQQIFA-AFFSEAFSVIIAAIDLQEETIIKDISDAY------SVLVKFDDMEETLEVLLDYIRKCSTSKEARIVYIILQNLPNISFRYQKKICKLLLDIYPQLHSIDYQAPVANALQNIIPFTYEKTESIEEFVKELLQVCSNLTDTRGDV--IRKPAMKAIS----------SLLVKDSSGKKLSEDIVWCCISYIIRQTFDKIDSLRGL--------AYQALEQIRVHYLIRRCEALTNIINRISFRNNPNMDGEVLNELNISLLEIPNLRLQAFYGITVFTADGFGS-VKCFEFYLSYVYQL---------EDSFKKSNSRYGKRDLLQLYIDILSDEIARFYFPIMKSFTSLLAYGCFTDFQNV----------------KGMSKAIFIVQRRALTCKSPGGLSAILELYRTLFLSKNELLHALKYTANLLLNPIEKDTLLYAKSIGLLTFLP--NELNQKLLTLDWFVPVSQNATFVKQLRNIIQKQIDKLIA........... 1105
17 -15.300[U] KOG0547 Translocase of outer mitochondrial membrane complex, subunit TOM70/TOM72  ali follow..  5................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SLLRFITKNKVAILATVSAGTAAVGAYVYYQQIKQQQQQQLKGTKDNRRQSEAFAGQNEDEADLDDGSVVSGSNKRKKKKNKRKRNNKAKSGEYPSLPNGEPDIAQLKGLSPSQRQAYAVQLKNRGNHFFTAKNFNEAIKYYQYAIELDPNEPVFYSNISACYISTGDLEKVIEFTTKALEIKPDHSKALLRRA-SANESLGNFTDMFDLSVLSLNGDFDGASIEPMLERNLNKQAMKVLNENLSKDEGRGSQVSNTSLASFFGIFDSHLEVSSVNTYALLSDALQRLYSATDEGYLVANDLLTKSTDMYHSLLSANTVDDPL---RENAALALCYTGIFHFLKNNLLDAQVLLQESINLHPTNSYIFLALTLADKENSQEFFKFFQKAVD--------------LNPEYPPTYYHRGQMYFILQDY---------KNAKEDFQKAQSLNPENVYPYIQLACLLYKQFNETKLKFPTLPEVPTFFAEILTTAIKQYDIAKRLE--------EVQEKIHVGIGPLIGKATILARQ--SSQDPTQLDEEKFNAAIKLLTKACELDPRSE--QAKIGL-AQLKLQMEKIDEAIELFEDSAILARTMDEKLQATTFAEAAKIQKR---------LRADPIISAKMELTLARYRAKGML................. 639
18 -15.200[T] COG5635 Predicted NTPase (NACHT family)  ali follow..  118............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LFLDSLDEGLLNVKSLAIGLVDEFKKPKYRSHINRLHLRLTALKALWEESNFAIYELA-IDVINAVEAEGFSSDDFL----KAINQRDIVPLAIKPISLGFLLNTYRRHNSQ---------PE-------------------QKRYESYLEGCKCLC-------EEVSKCRHALKETGNLDIDQRLIVAARIAAVTIFANRFAVWIDVEQGQVPAEDVPRQKLCFGYEESNGREFEITQEVIQEVLDTGLFHRMGWAHQTYAEFFAAWYLTQRNIDLSKIKTLLYSSADSTPKLIPQLHETA---------------VW---LASMRDNVFQEIIKTDPDVLLQTDIPTDSELRATIVANLLMQYEEEKDRGFCNVRNYAKLKHSGLAEQLKVYICDSSKKEDTRRIAIDIAIECNSQPISIRVNAARAISSI-QSTRLKLKSLALNVLPEDEQDELKAYALKALWPRQLTAEEL----------FQALTPSKRINLLGMHRYFLESELVPQLDSEDLV---ALDWLKTQGVRCFGHPFEELGDAILLKAWEHVNVPGVLEGFTQVALLQWKEHQKLISHSPSLQAQFQESLLGNNQKR-------------------YALIENLVESIAEKDEDEDFYFLTPIISSND-------VDWMLEKLQDSNHEKIQRAWAKIIEEVFD-----RRDTKQISEIIKATQNNSILSDVFSYYFTPIELDSEEVTQLRDHYLKMKNSWNKPDLLDPPPK------ERVIDCLEQLESGDLSAWWRLNREMTLLPQSKRYGEQATKKRIIQGAIQYIQQQTNIGCKALQLILTEAPRTLDNFSTDIWKRWTPIILSVPNSFIDS-NPRKNCRKLVSLSYHHSP-DEFLTTLLKLIDKENQDNNIFVIDRLEMCWDEKLENNLTEKVKDSQLKP---VFRKLLEKLIEQGA----VQAKDIALSTIRNYTNSEFDSERQKALFAIKALDSWNVIWEKITADVQFGREAFELAASCNLSGIKFDLTEKQIADLYAWLVWQYPHYEDPDHRNEVMAYIVSPRDNIAFFRNNSLSQ---------------LRDKGTIE-ACAELERLIQEL------------PHLPWLKETLTYAQQNMRRETWRP----FKPDKLL-------------------------EFLIIPEPSNLDLSNQ---------------LSTIDKRTEKMEDEPKIINNISDSTINAPVGTSGVTSNNVTCSSPEKQKRFNWEGIIGVIATVVGIFFNGIFNDVLDSLNGSSKIEQQAM---------------PKN................................................................... 1319
19 -15.100[T] KOG4162 Predicted calmodulin-binding protein  ali follow..  11................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TKVEALIESCRSEGK--HRVIELTDELKTECLANFLVGEARLESYLEENALASDSNF--GRAKSGLAEAR-RFLHLALGESGQKAGIALDAYLLLAKL-------------------------ACGEYEQSLDNFVKAELNTLAEKELTLRSLKISYAIKGLCQQTTKPSSKFKKAEKDTEMISCFERASDLGLLYLQEYDLVSGSSGSSNNSTAGSTLNVNASTVQP---SSSSFAISSTIPASGPSGL--------EMNRRMGAILETALQRAPIVLIKTEKLQEAVERYRIMLNAIETRATQSLRLTLARQLAEVLLR---------GVSGTIYSPPFTGKSGGGTLRGGSSKKLWKPRKYAARQQFNPR-----QQEEVILLLLIAEALAVRDTVLSQSPEFRQARQHAMGNVTAVYDLLT---------------------LATVRWGLVQLLNESFEKALKFSFGEQHVWRQYGLSLMAAEKHSHALRVLQESMKLTPSDPLPCLLASRLCYESLETVKQGLDYAQ------------QALKREVKG-SRSQLFVGIGHQQLAIQSNLKSERDACHKLA---------LDALERAVQFDGNDHLAEYY-----LSLQYALLGQLAEALVHIRFALAL---RMEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLVKAHLQLHLEDAETALGTVQHMLAKHSDTKSGVHLAHSSQMSDKDSNSVYAASLAAVSRVEQALSEASSLSSFTQRPGPRRPWMLQIEIWLLLADVYLRI-------------------DQPNEALNCIHEASQIY--------PLSHQIMFMRGQ------------------VHVYLEQWFDAKQCFLNAVAANPNHT-LRALGEAHLVLGE-----PRLAEKMLKDAAKLDPSCPIWFALGKVMEILGDFHASADCFATSLQLEPSCPVLPFTSIPLVFE..................... 861
20 -14.800[YU] KOG2022 Nuclear transport receptor LGL2 (importin beta superfamily)  ali follow..  10  5.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EIAHAKKLVYDLYSGSLSPSAIAATEKELQKA---------QRSQQGWNIGLFMLQSKDVYEQFFGALTLQMKINTQLETLSDKDLVQLFVQLLQKLLWDDGLPALVERKVICTLASLTIKYELEKKEEASLKVIYCLFCNKLEFFNNAASVLNNLFPPASSRNAQLTASYINELLLELSFSIYTKENEDALFNNVFRPCSNIIVS-----VLVFIFTNYSLDLSKEKNVAALEEALNCMIAISS------YLAKASVSVQSVLPAFTECMDLTVNCIALDEVSEKAMNCLADLLANYSNFITQPTIERLWTILTGPWGETHLQQELEDPDSGEENDYS-FLNIVIGFAEAMLPQIIDHIQEEKSIRL--LYILASLLS---------------YAIVEEKVSWRTLEFWTTLIEDFSMSKFKQIAFSVVEKAWWKMLLPSPEQWNSWPSSSRDSFNSYRRDLGDLLESSYSIFGERLYAMYITTIENFFSDGTGS------------QSLEVSFYCLCCILEYDTND---------SDTLDAWLTRLFETSFAIKAS-AFQNPQLLKTCSQLLSSCSC--------------------LQNHPQYLNISLPVLFDAL-----HISETSIQMTVSRSIHTLCTTC---------------------------ASHLLTEIDG--------------------------FMAVVEELTPKYVPSVLEKIYSSVGYVTQR---------IE----------DIELRISYLMRLLNCILAQLQPSLYPNLEIFENVLKSCL-QSVAGVALSQSPIGESPIIDVEQSTQETTFWQQSCIAEFQAKLISFLTHSESMALQYSVVGLI--CKIMIAGLNEVEPSPFS------PIVTTIQYFCDRFTEFPAAVLLT-LTCPYGQTDIIDKVLIDMCSSIQNSVVIINEESFMNNIDITVELYHFFSII--------LQKHPSFLETMYPDFTQLILNRAINLL------------KPERLLESAAGQFIISFITSEKSDLLNTHTDFVNAIRSPLIAKILLGFGGNASRS-----SLPLLSDLGKLKAQNFSATRACLTQSLEEEGFPSRNVSNEIKRRFLTDLL---ARIKDKVKQFWI----LCKGLESTPYGNSSW............................................................................................................................................................................................................................................................................................................................. 988
21 -14.700[S] KOG4340 Uncharacterized conserved protein  ali follow..  29............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EAVQLLGQLHPELEQAQALYKACLYPEATRVAFLLLDNPAYH----SRVLRLQAAIKYSEGDLPGSRSLVEQLLSGEGGEESGGLYKEGQYEAACSKFSATLQASGYQPDLSYNLALAYYSSRQYASALKHIAEIIERGIRQHPELGVGMTTEGFDVRSVGNTLVLHQTALVEAFNLKAA----IEYQLRNYEVAQETLTDMPPRAEEELDPVTLHN-----------QALMNMDA---------------------------RPTEGFEKLQFLL----QQNPFPPETFGNLLLLYCKYEYFDLAADVLAENAHLTYKFLTPYLDALITCQTAPEEAFIKLDGLAGMLTEQLRRLTKQVQEARHNRDDEAIYIPVLMAQAKIYWNLENY--PMVEKVFRKSVEFCNDHDVWKLNVAGFYEPIVKKHYDNILNVSAIVLANLCVSYIMTSQNEEAEELSYDDPNRKMYHLCIVNLVIGTLYCAKGN---------------EFGISRVIKSLEPYNKKLGTDTWYYAKRCFLSLLENMSKHMIVIHDSVIQECV-QFLGHC---------------ELYGTNIPAVIEQPLEEERMHVGKNTVTDESRQLKALIYEIIGWN...... 627
22 -14.200[DO] KOG1174 Anaphase-promoting complex (APC), subunit 7  ali follow..  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MNVIDHVRDMAAAGLHSNVRLLSSLLLTMSNNNPELFSPPQKYQL-----------LVYHADSLFHDKEYRNAVSKYTMALQPQSQCLPSEIEVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINLYKKAGRERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASM---TMNVIQTVPNLDWLSVWIKAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGLYFRAGDNKNSVLKFEQAQM-----LDLYLIKGMDVYGYLLAREGRLEDVENLGC--------------------------------------RLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNQALLLKGAALRNMGRVQEAIIHFREAIR--------------LAPCRLDCYEGLIECYLASNSI---------REAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEK------------------AKTLLDKALTQR--------PDYIKAVVKKAELLSREQK------------------YEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLD-----PNDQ----SLEGMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQWF.......... 562
23 -14.100[R] KOG1124 FOG: TPR repeat  ali follow..  18................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NTSSFSLSFLTPQIPENLCKSPTKIHIGTHGISGQSFLSHPTFSSKNTYLYAVVDRS-SANGEGEESNTEEGVLVVRRPLLENSDKESSEEEGKKYPARIDAGLSSSSAAAAARAQERPLAVNLDLKVLARNFRYKDAEKILEKCIAYWPEDGRPYVALGKILSKQSKLAEARILYEKGCQSTQGENSYIWQCWAVLENRLGNVRRARELFDAATVAD------KHVAAWHGWANLEIKQGNISKARNLLAKGLKFCGRNE--YIYQTLALLEAAGRYEQARYLFKQATICNSRSCASWLAWAQLEIQQER---AARKLFEKAVQASPKNRFAWHVWGVFEAGVGNVERGRKLLKIGHALNPRDPVLSLGLLEYKHSSANLARALLRRASELDPRH---------------------QPVWIAWGWMEWKEG--NTTTARELYQRALSIDANTESASRCLQAW----------------GVLEQRAGNLSAARRLFRSSLNIN--------SQSYVTWMTWAQLEEDQGDTERAEEIRNLYFQQRTEVVDDASWVTGFL-------------------------DIIDPALDTVKRLLNFGQNND----TTLRNMNRTKDSQSNQQPESSAGREDIETGSGFNLDVFLRSKLSLDPLKLDV.......... 634
24 -14.000[A] COG5178 U5 snRNP spliceosome subunit  ali follow..  462...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QPVKVRVSYQKLLKSHVMNKLHMAHPKSHTNRSLLRQNTKFFQSTSIDWVAGLQVCRQGYNMLQLLIHRKGLTYLHLDYNCNLKPTKTLTTKERKKSRREILRLTKLIVDSHVQYRLGNIDAYQLADGLHYIFNHVGQKYRLMRQIRACKDFKHLIYYRFNTGPVGKGPGCGFWAPS-LRGIVPLLERWLGNLLARQFEGRHSTGVAKQITKQRVDSHQDLELRAAVMNDILDMIKSKTILQHLSEAWRCWKANIKVPGLPAPIENMILRYVKSKADWWTSVAHFNRERIRRGATVDKTVAKKNLGRLTRLWLKAEQERQHNYLKTADEAVAIYTTFVHWLESSYKHDTKLLVLALERLKE-LNQSQREELALVEQDNPHEMLSQIKRRLLT-----MRTFKEVGIEFMDMYSHLIPV------------SVDPMEKICDAYLDQYLWFEADRRHLFPSWVKPSDSEPPPLLVYKWCQGINNLTDVWETSNGECNVLMETRLSKVFEKVDLTLLNRLMSASYASAKNNVVLSYKDMLVRGLQFSSFIWQFYGLVLDLLGPADAPNDFLHFKDQATETSHPIRLYTRYIDKVYIMFRFTDEESRDLIQRFLNENPDPTNSNVVNYSKGKSKDNPNLLFSMTGFEVRILPKIRQNEEFSLKDGVWNLTDNRTKQRTAQAFIRVDGINQFGNRIRQILMSSGSTTANKWNTALIALMTYYREA-----STPELLDLLVKCESKIQT---KISLNSKMPSRFPPAVFYSPKELGGLG-MLSMGHVLIPQSDLRWSKQTDTGITHFRSGMTTNGEHLIPNLYRYIQPWESEFID--SQRVWAEYAMKRQEALQQNRREDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTE--FKQYQLLKNNPF-NNYRVDV-IQALGGVEGILEFKATGFPSWEGLFWEKASGFEESMKFKKLTNAQRSGLNQIPNRRFTL---WINRANV--KIPTLKISLIQIFRSH--------------LWQKIHESVVWDLCQVLDQELESLQIETVQKETIHPRKSYKMNSSCADILLLAAYKWNVSRPSLLNDNRDVLDNTTTNKYWIDVQLRFGDYDSHDIERYTRAKFLDYSTDAQS---MKPLIQQSMNKIMKANPALYVLRERILQLYASEPQEQYLSSSNYAELFSNQIQLFVDDTNV-TIHKTFEGNLTTKPIFIFNPRTGQLFLKVIHTSEEVAALIRSLLEVHLLDFPNITI---LQLPFQAIIKLDKINDLILRATEPQMVLFNLYDDWLQSVSSYTAFSRLILILRALNVNTEKT 1974
25 -14.000[DO] KOG1155 Anaphase-promoting complex (APC), Cdc23 subunit  ali follow..  10  5.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ECCRNEIRAAIRQLSDRCLYSAAKWAGEQLVG-IEQDPSNFTPANTRFQRGSSSIRRRFSTNESISTPLPSVGFSQAATPLPEEDEAILLAKSYFDCREYRRALRYYALYLAGEKRKEEEMIELEGPLGKSDAINRELVSLERDLSALRRTGAIDS-VVLKEKGNESLARASLVESVNSYPWNWSAWSELQSLCTSIEILNSLNLFLGNAYQELRMHTESLAKY--------------EYLQGIFSFSNY--IQAQTAKAQYSLREFDQVEIMFEELLR-----NDPYRVEDMDLYSNVLYAKEACAALSYLAHKVFLTDKYRPESCCIIGNYYSLKGQHEKAVMYFRRAL----KLNKKYLSAWTLMGHEYVEMKNTPAAIDAYRRAVDINPTRAWYGLGQAYEMMGMPFYALHYFRKSIF----------------------LPNDSRLWIAMAKCYQTEQLYMLEEAIKCYKRAVNCTDTEGIALNQLAKLHQKL-------------------GRNEEAAYYFEKDLERMDAEGLEG-PNMFEALVFLATHFKNHKKFEEAEVYCTRLLDYSGPEKEKAKSLLRGIRMDLEHFPI....................................................................................................... 579
26 -13.900[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  1..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MNFLRGVMGGQSAGPQHTEAETIQKLCDRVASSTLDDRRNAVRALKSLSK----KYRLEVGIQAMEHLIHVLQT-DRSDSEIIGYALDILYNIISNEEEEEVEENVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQII---------------LVSPMGVSRLMDLLADSREV-------------IRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIISEEGNSDGGIVVE--------------------DCLILLQNLLKNNNSNQNFFKEGSYIQRMKPWFEVGDENSGWSAQKVTNLHLMLQLVRVLVSPTNPPGATSSCQKAMFQCGLLQQLCTIL-MATGVPADILTETINTVSEVIRGCQVNQDY-------FASVNAPSNPPRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVSTL-----------LPSTIDATGNSVSAGQLLCGGLFSTDSLSNWCAAVALAHALQENATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGSKIQTRVGLLMLLCTWLSNCPI--------------AVTHFLHNSANVPFLTGQIAEN-----LGEEEQLVQGLCALLLGISIYFND-------------------NSLESYMKEKLKQLIEKRIGKEN---------------------------FIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLV----KELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTA------VTQQVSQIQQHKDQYNLLKIQ-LGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDS--------MIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSV--EITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKEL-----------KNEIKALSEERTAIKEQL-DSSNSTIAILQTEKDKLELEITDSKEQDDLLVLLADQDQKI-LSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPG...................................................................................................................................................................................................................................................................................................................................................... 956
27 -13.800[G] COG3459 Cellobiose phosphorylase  ali follow..  29...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FFERHRENEKEILRVYRTTAVDAEN-ITPAAEWLLDYVIEEAIQEVRRDFPRKFYRQLPTMTVGRVMALGWLYVAHTHSTVSRENMTALVDGYQTSQTLQIGELIRFVLIENLRRISIRVERSRRMRQKANEVVDEIIRLNDAEASAALLKQVDSLVDDPTFATQFLYRLRNGSQTSGFEERLHAAGTDAENVMMSEHNRLASGNVTMGNIVKSLREIDDTE---------WSVWFEEVS------HIDKVLRE--TDYEILDFGSRNTYRNTIELLARRSP------------RTEVEVARAAVEMARSDLPAGADENHRVNVGSVLVGQR----RFELEKALGYRPLASQHIVRSMRKFNWLAIAAPLITAVAMLAVGWFLAKAGMPWYVVTAFLLMFALPASEGATGLFNTFFVKPFRLVGYEFKNGIPEDARTLVAVPCMLTSRDSVDEMMRNIEVHYLIYFSLVSDWRDAPYEQSDEDLEILDYAKRELAA-----LNSRYAFDGKTR------LLHRRRIYNSWM-------------ERKRGKLHELNMLLRGDKDTT---VPADVKYVMTLDADTRLMRDAVTKLVGKMHHPINRPKIDPVSGRVVE-----YGLL----------QPRVTPSLTTGKDASVFQRVFSINRGIDPYVFTVSDVYQDLEGTFTGKGLYDVDAFEAAL---------KGRIEENSILSHDLLEGSFARCALVTDVELVEDFPTRYEVEVSRQHRWARGDWQLL-----IIDRARGVTAIGRWKMVDNLRRLTPIAWFFASILGWYFMDPLGALIWQILLIFSLFVAPTLSLLSGLVPRSTDIVPQAHFHTIWSEIRATNAQVALRIVF------IADAACMMTDAIVRSLYRLLVSHKLMLEWRTAASMQSSAQGSIVDYYRQMW----------APVVAMLGLLFAALPGDNAFTLLWVLSPAVAWYVSQSAETEDR--LFVSEHVSFELRKIARRTWR----EAFVTPQENHLPPDNFQETPEPIVASRTSPTNIGVYLLSVIS------ARQFGWISFADTLERIENTIQTVEKMEKHRGHLYNWYHT--------------------DTLQTLGPRYVSAVDSGN------AGHLIAV-AHLQGNLDGIGDVAGILRETLKALPDNRKTLRPLHRRLEERIIGF--SNALASVKREHEFASIRVINLAVLIQKLATNVDHEVKSAQSAEVTRWAQLLVESCEAHISDSLASLRDRSRNLAFSMDFTFLYRKDRRLLSSLFAIAKGDLPTEH. 1289
28 -13.600[YU] COG5101 Importin beta-related nuclear transport receptor  ali follow..  1...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MEGILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEIL------------TKFQDNPDAWQKADQILQFSTNPQSKFI---------------ALSILDKLITRKWKLLPNDHRIGIRNFVV------------GMIISMCQDDEVFKTQKNLINKSDLTLVQILKQEWPQNWPEFIPELIGSSSSSVNVC-----------------ENNMIVLKLLSEEVFDFSAEQMTQAKALHLK----------NSMSKEFEQIFKLCFQVLEQSSLIVATLESLLRYLHWIPYRYITNILELLSTKFMT-----SPDTRAITLKCLTEVSNLKIPQDNDLIKRQTVLFFQNTLQQIATSVMPV------TADLKATYANANGNDQSFLQDLAMFLTTYLARNRALLES---DESLRELLLNAHQYLIQLS---KIEERELFKTTLD-------------------------------------YWHNLVADLFYEVQRLPATEMSPLIQLSVGSQAISTGSGALNPEYMKRFPLKKHIYEEICSQLRLVIIENMVRPEEVLVVENDEGEIVREFVKESDTIQLYKSEREVLVYLTHLNVIDTEEIMISKLARHNINTLSWAIGSISGTMSEDTEKRFVVTVIKDLLDLTVKKRGKDNK-------AVVASDIMYVVGQYPRFLKAHWNFLRTVILKLFEFMHETHEG-----QDMACDTFIKIVQKCKYHFVIQQPRESEPFIQTI--------------------IRDIQKTTADLQP----------------QQVHTFYKACG-------------------------IISEERSVAERNRLLSDLMQLPNMA--------------------WDTIVEQSTANPTLLLDSETVKIIANIIK---NVAVCTSMGADFYPQLGHIYYNMLQLYRAVSSMISA-----AAEGLIATKTPKVRGLRTIKKEILKLVETYISKARNLDDVVKVLVEPL---NAVLEDYMNNVPDARDAEVLNCMTTVVEKVG---------------------HMIPQGVILILQSVFECTLDMINKDFTEYPEHRVEKLLKVINEKSFAAFLELPPAAFKLFVDAICWAFKHNNR--DVEVNGLQIALDLVKNIERMGNVPFANEFHKNYFFIFVSETFFVLTDSDHKSGFSKQALLLMKLISLVYDNKISVPLYQEAEVPQGTSNQVYLS-QYLANMLSNAFPHLTSEQ-IASFLSALTKQYKDLVVFKGTLRDFLVQI---------------VGGDPTDYLFAEDKENALMEQNRLEREKAAKIGGLLKPSE................... 1081
29 -13.400[D] KOG1915 Cell cycle control protein (crooked neck)  ali follow..  8...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DRNLGYMTRKDAELKLPRMTQVKNKTPAPIQITAEQILREA-RERQEAEFRP-----------QTITDSAELSDYRLRRRKEFEDQIRRARLNTQVWVKYADFEMKNKSVNEARNVWDRAVSLLPRVDQLWYKF-IHMEEKLGNIAGARQILERWIHCSPDQQAWLCFIKFELKNEIECARSIYERFVLCHPKVSAYIRYAKFEMKHGQVELAMKVFERAKKELADDEEAEILFVAFAEFEEQYKFALDQIPKIGKRRCQYEDEVRKNPLNYDSWFDFVRLEETVGNKDRIREIYERAVANVPPYLWINYAFFA-VTEDVESTRDVYRACLKLIPHSKFSFAKIWLLAAQHEIRQLNLTGARQILGNFKKELQLRNIDRCRKLYERYLEWSPGNCYAWRKYAEFEMSL-------------------AETERTRAIFELAISQPALDMPEL------LWKTYID------------------FEISEGELERTRALYERLLDRTKHCKVWVDFAKFEASAAEHKED-IKRAREIFDRANTYNKDSTLLEDWLNMETGFGK-LGDVRVVQSKLPKKVKKRKLSEDGCTEYEEYTDYSLKILEAAHKWKKQKVK 652
30 -13.400[DO] KOG1173 Anaphase-promoting complex (APC), Cdc16 subunit  ali follow..  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MPGDTENTSTDTTNEHID---------LALYRQLVKQFIDMRRYSTALFWAEKVAVLGGLEPR----------------DIYYQAQCMYLLGEYHRAAHTIQHHKLEKNSAAKEFTEAANVIQNVEVEVMTTSLINQPVDASSGCYLESN-KVYEALDNRGMAMDFYVQALHKSIYCFEALEALVQ-MLMAWEEFELMHHLP-LAQQSSEADAKFILKLYES--RLKKYYELISARNAEENPDILQFIKEFTARVQQSGSSDTQMPKVSAVKVPLTPSQFMSPAQKVLEDLK-APTFSLQTSLSKASSLIDASHRSMFDSSSRRRSR-----HDTDTLIPIAECL----DRVQRSTDLMAAEAEKCFYDCDYKQCLKILNELLKVDPNTALTIQIACLVENGDFNRLFYVAHKLVDRYPDKAISWYAVGDMIGKSDPARRYLSKATALDRLYGPAANENEHEQAMAAYFKATQLMRGCHLPLLYIGVECGLT-------------------KNLELAEKFFLQAMNIA--------PLDVYVLHELGVIKYEYEFFDGAATIFQCTVDIVKQRAKSNNEEISSRWEPL-----FINLGHSLRKVHKYEEAL-----YNFQYALLLKPQSPTYTSIGFIHALLGNLDPAIEAFHKSLALNRDCIVTSTILKSCIEDLMDDSATIDEI.......... 665
31 -13.300[YU] KOG1992 Nuclear export receptor CSE1/CAS (importin beta superfamily)  ali follow..  10  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVLLTLLEKSDNVIKVCASVTFKNYIKRNWRIVEDE-EADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGREDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKS--NELWTEIKLVL-------DAFALPLTNLFKATIELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFWEGNMENNFHTLLTLDNKLLQTDICDNAALYAQKYDE-EFQRYLPRFVTAIWNLLVTTGQEVKYDLLVSNAIQFLASVCERPHYKNLFEDQNTLTSICEKVIVPNMEFRAADEEDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNPHKDAAIYLVTSLASKAQANELVNLTEFFVNHILPDLKSANVNEFPVLKADGIKYI---------------------------MIFRNQVPKEHLLVSIPLLINHLQAGSIVVHTYAAHALERLFTMRGPNNATLFTAAEIAPFVEILLTNLFKALTLPGSSENEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQKLLAVSKNPSKPHFNHYMFEAICLSIRITCKA---NPAAVVNFEEALFLVFTEILQNDVQEFIPYVFQVMSLLLETHKNDIPSSYMALFPHLLQPVLWERTGNIPALVRLQAFLERGSNTIASA-AADKIPGLLGVFQKLIASKANDQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQNSKTTKFIKSNLYCIKYGALALQEIFDLEKIIIPEIQKVSGNVEKKIC------------------AVGITNLLTECPPMMDTEYTKLWTPLLQSLIGLFELPEDDTIPDEEHFIDIE--QLAFAGKKEHDPVGQMVNNPKI--LAQSLHMLST----ACPGRVPSMVSTSLNAEA---LQYLQGYLQAASVTLL................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 971
32 -13.200[O] KOG0548 Molecular co-chaperone STI1  ali follow..  8..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KGNAAFSSGDFTTAINHFTEAIALAPTNH----VLFSNRSAAHASLHQYA--EALSDAKETIKLKRLGAAHLGLNQFELAVTAYKKGLDVDPTNEALKSGLADAEASVARSRAAPNPFGDAFQGPEMWTKLTSD--------------------------------PSTRGFLQQPDFVNMMQEIQKNPSSL--NLYLKDQRVMQSLGVLLNVKFRPPPPQGDEAEVPESDMGQSSSNEPEVEKKREPEPEPEPEVTEEKEK----KERKEKAKKEKELGNAAYKKKDFETAIQHYSTAIEIDDESYLTNRAAVYLEMGKYNECIEDCNKAVERGRELRSDYKMVARALTRKGTALTKMAKCSKDYEPAIEAFQKADAERAKKEWEQKQYFDPKLGDEEREKGNDFFKE-------------------QKYPEAIKHYTEAIKRNPNDSYTKLGAM----LKDAEKCIELDPTFSKGYSRKAAVQFFLKEYDNAMETYQAGLEHDPSNQ-LDGVKRCVQQINKANRGDLT------EELKERQAKG-----MQDPEIQNILTDPVMRQVLSDLQENPSAAQKHMQNPMVMNKIQKLISAGI............ 568
33 -13.100[Z] COG5245 Dynein, heavy chain  ali follow..  233..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LKQTLAIDRDIKNGSFLDEVEFWSNFYEVLKSLIEQTQSQEFQVCLSVLTN-AKRFHNLTNLLNEGSLSDKFKLADKYNQFLSSIPIDEVRQASNLEDLQELFPVLASSLKKFRYSGYPVQRFV-VLMDKISQEVMDAILSNLSDLFQLEYGSFLGLYEKSAGMIEEWDDIVQDVNLLIREDLRKRAPQELLIQKLTFTSASVKATLDRKRFFSLAETIKSISPSTYHEEIQRLYHPFEQIHDISVNFRLKSEFSKNMLDLEKKLQNTLASFMDSDHCPTEKLSYLVKFKPLM---------ELCPRIKVKVLENQQILLLEIKKDIRQLETGLELLPKILHVEALNNIPPISARRIDNIVQYLEALFGSNWNDTLEGRSISTSIVQLRKETNPHDVLHWLGNFPEKATANLLTTPILKLIRNNEDDYELKVNFDFALAAAYSELRSLTYMA--SHIVRIARTYMYLYPRAINLVELIQTFFSLSKSLS--YTFYTNIFLKRNVQTVWLLLQQSSEMSCSVHSLARLEKSIDGILSDYQILKNSEPQFAKEFSGLKSFDGTADDLHEVEEIISNIQAIFENLNLIISIILEKVRLNLKKMHFPKHVLKLSFNEGRITSSPSLAAMKRSLLKDIEALLNKVVLINFLHDPDHPLSTTLTFNSLVIKLKDDIQNCIEQ-KEWQKMEFLWLKGLLDSQSKFDLIISRNNFSKNLVLHTEDAQRHIRSKMVSKHLLTIYERDARKLHEDMNRDREAVEDMDINFTSLKNITVIIEAVNVNKRHLTERDIQIKLLGSVMRALTKLKVRFPSHFVYIDQLDNDFSSLRQSLSYVEQELQKHRVVIAKSLEEGVENINNLSQSLNES-EFFNESITKLKKKMHSVAAAAKMLLIVLNDQLTHVVEEVKTYDLV--WRSIKNLWRVDVLLLQSDLANFLRRADELPRAVKQFEMYKSLFSQVNMLTSVNKILVELKDGAL-KPRHWNMIFRDIGKRQIQKNLLDKLEFSLKDVMVLNLTLNEILLTKIIERAQKEFVEKSLNRIKKFWKEA-GLKLVREWDVLEQACKEDLEELVSDLESKLTKLSEIQVNLYGILGIQNFLPLETSKFKSLTSEYKMITTRAFQLDTTKSSLSTFLERQRRQFPRFYFDLLKIIGSGKHHDQVSKFMKKMFGSIESIIFLEDFITGVRSVEGENEKIELKDSIQAQEWLNILDTEIKLSVFTQFRDCLGQLKDGTDIEVVVSKY-AQVMWTELVEKCLQTNQFSKYWKEVDMKIKGLLDKLNKSSDNVKKKIEALLVEYLNVIGQLKNCSTKEEAR-AKVQKFYQKNDTLDDLNSVFISQSGY--KFEYIGIPERLI--YTPLLLIGFATLTDSLHQKYGGCFFQNLGRVVVVFNCDDSFDYQVLSRLLVGITQIGA----------CFDEFNRLDEKVLSAVSANIQ.... 1866
34 -13.100[R] COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster  ali follow..  4...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SVVSRQVADSVAAFLRAAFPLNSPLFNGENNDNVSMLEQFLAQPETLLKGPYLSAQLPFRKSDLPLNFFPNLTLPFPPHAHQARAFQRLGSDAPQPTLVATG----TGSGKTECFMFPLLNHCAGASQAGVKAIIIYPMNALATDQASRFAKTIASDPQTVGLFVGDSEIEPSKKMSAEKVITC-------KHTLRESPPDILLT-NYKMLDYL--LMRPGDQPLWRYNQPGSLRYLVVDE------------LHTFDGAQGSDLACLVR--------RLKHHIGVDNQRFACVGTSATVG------------DELGQLLDYAKT-IFDQPFTDDAVIREDRYTAAEYLQNYA-QSYATPVAYLNGQIPLWFPDSDLQLPDDLESDDGREKRIALGSLLRRHSVMHVLLHDLRECLENLQVMLAESADHARRVLQSILALIAQARLEVPET----------EHDRQKRLQAKKARPVLPFVQLRSQLWLR------------EMRRLVASVAKTPRLVFADDVAVEDREHYLPVI-------------------HCRDC-HATSLRHGQSVQLETDLDGIYRQFFEKGRS--------------IVLAFPDNNEKAVSGAHQKLCPTCLKLNRQSSVQCGHCGHTELLQVLIPDMLKERK------DELEFANECPYCNSKQGISILGSRAASLSAVMIHQLYGSQFNEHKKLIFS------VQDAAHRASFFIRGQIASVLSEKETLPLDAFAARVCQQTRERSPDDAHFAANVIAPNMQWL-----------YQTLKNEGKLAENSDLPELVSLRLDWEVYSEFTLRARIGRTLEATGYAVAGVDKDRFNPAITALHQQLCEELGDEMSGVSVEQVAHLALGVIWYQRQAGAVMHPAFESYRRDGTTFMMTQKERTSRYMPSIGPKTRKPAYASFEKINGFHRLIGAKSNPSWYQHWINRTLSNGNNLFISSVAETVLRRLFTALKIAGVVKDFDTKGREAWGLVPSALVVSRDVVAPADQGWQWRNAPCLSLRCEGRYQEVDNTATWRWENMDIARVQGAEHTGLLSREDREVTEKSFYRNLLSATPTLEMGIDVGDLSTVLLC--SVPPAQANYLQRIGRAGRKDGFFEEPLEMM--QGQVQAPGVFLNATAIL----ERQLAAFCMDNWVKTGVPESAICKNVKQMLDELEFGRKSGFPYNLL--RYIEQHHAEIAAQFTAIFPDLAAETRQQLLSYLQGAPGQRSLVQR----------------------IEEALKLLVEDRKSLRSRIDKLKRSIDKLENAPRDQNFDSDMRELTSERQALMALVNQINNKQTLNFLTDLPNYAFPEAGITLRSVLWRRKEGGEAEYERPASTALAELPLNNFVEIEQIDLKVSEPEN.................................................. 1348
35 -13.100[LA] KOG2044 5`-3` exonuclease HKE1/RAT1  ali follow..  5................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AFYRWLADRYPKSISDVVEEEPTDGGRGDLIPVNPNGFEFDNLYLDM-IIHPCFHPEGKPAPATYDDVFKSMFEYIDHLFTLVRPR------KILYLAIDGVAPRAKMNQQRSRRFRAAKDAAEAEAEEERLRKDFEMEGQILSA--ETCDSNVITPGTPFMAILSVALQYY--------QSRLNHNPGWRYVKVILSDSNVPG--EG----------EHKIMSY----------------IRLQRNLPGFDPNTRHCLYGLDADLIML----SLATHEV------------------HFSILREVITYPGQQE---------KCFVCGQTGHFASDCPGKSGSNNAAADIPIHKKKYQFLNIWVLREYLQYELAIPDPPFMINFERIIDDFVFLCFFVGNDFLPHMPTLEIREGAINLL---HVYRKEFTAMGGYLTDSGEVLLD-----------------RVEHFIQAVAVNEDKIFQKRTRIKQSMDNNEEMKQRSRRDPSEVPPEPIDDKIKLGEPGYKE--------------------------------RYYAEKFSTTNPEETE---------QIKQDMVLKYVEGLCWVCRYYYQGVCS----WF----------------PYHYAPFASDLKNLPDLEITFFIGEPFKPFDQLMGTLPAASSNA----GEYRKLMTDPSSPILKFYPKRFAWQGIAKLPFIEEKLLAATRKLEETLTVEEQQRNSVMLDLLYVHPAHPLGQRILQYYHFYQHMPPH 638
36 -13.000[BD] COG5218 Chromosome condensation complex Condensin, subunit G  ali follow..  75................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IDIVQPILKHILRGLDAKDKTVRYRCCQIIARVVNCVKEIDDDLYNTLKEKLLSRVLDRESIVRLEAVVALSRLQEDTGDEE-----NDVRNILLFLLQ--NDPSSEVRRSVLLNIE---------VSNSTLPFILERARDVDAANRKCVYARVLPKI-----------------------------------------GDFRYLSIKKRVRILKWGLNDRDESVEKAAADMLAYQWIENADNNLLELLERLDVSNNSDVAVLAIKKFFDVRVDSLSQLEFP---TAESSLLARTFNEICIEKNYTDLLDKMPEVVQ---------------------------LTYYIERQYVSLRDKSSYDESCFIIEQLLYIGLSQDMVDEIGRRKLLKSLTNSLSTMALPDSLISLHIELLRKLSENDFCSLLVEIITEVFEQGHSQNQTEEQGNSNAPELNKNDYEGE-----------------EITVSQKSPSPSLPPNELNEPEPDDMDGYKEAFNELRCLSYVQCLFENITSSLNE-------NLYMVDMLKTLI--IPAVRSHDLPIREKGLECLSLVCLLNAD------------------------------LAFENVPLYLHCYEKGSVVLKCTAIRTLTDMLIQHGKAKFTEYEDAISSILFEALGEFENAELQTLGAE------------------------------IAKLLHYRDELFLKPLIIQYFEPNTVDNHALRQVL---YFFPVYAFGAHENQWRIATIFCDALLSLLEIYRDLDEDDVQLSIGHIAQQMLDWTD-------------NEKLYERKTQTGDDYIALNHNVHLHLANMIFESL---PNASEGKERKFMISLLGKLKI-------PTDLPSSDYQRTKRKLETYESHGFTMDSTSLSILAKFERMLLQNEEARSKFEETEEERLMENAEENEHAGAEAISGEIIPDTVEANMEDEEEVYVKQEED...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 874
37 -12.800[BD] COG5098 Chromosome condensation complex Condensin, subunit D2  ali follow..  3..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GFSLSYPRLQDPSRELNVIIDQLAVSPEQIDPDSLEALIDLC-----------------PHLTPKLQTQLSYLISSSLSNLSKDIKANLSSNVNFTEIGGLIPQWKRHLE-------------EYGYLIQVLLTFLQDELHKVSSQSTNLNRSAKNSKNDSANV---------CNQMENLLESITKLLE--------INLSKIFQTTPEKDLFIGLFTRPLFVLLEIEPVTVSSLKMFIQRILAMCVKNHGQSSSIQSSLMTNLTYFLHLSVNAELLKLLNDEYNYPQLTEDILKEISTVFNAKDTTGPKAISNFLIKLSELSPGIMLRQ-----MNLVITLL-------NNSSITLRCSVVEACGNI-------VAELAQDPQTM-----EHYKQQIAVLIELLEERF------------QDSNPYVRTKAIQ-------------------------------GCSKICDLS-----------------------KSKAKFTSLAVRSLQDRSS---------LVRRNSVKLLSKLLPFKLRLSEWEEYLKGSESQLNSTLKKVESQETLNDTIERSLIEEEVEQDEGQCRTELEGSFNKSAELSRIENEVENINATNTSVLMKLKLMIVYYKDAISFIKEIHKSI---FSKNRNEVLESMDFLVLADA-MKGTNDEGTSISVHLIECYKQL---TAPDSCNMQEKAAHIAKNLINLSIGASIAD-LASLEQLLGMMYEQKLIDQHVINILWAIYNSASKASMQKEQNVNNRDSEKGFSKEQIHGSI--------------------------IILGMLSLADNEIALKGLESLLNIGLGAVGLKDLTLCRYSCLALERMVPKRSTIITKAINQELEDVAVKKLYAIIINYTKDNEYYPMCEQALSALFTISSKPDILATDLIR-----EKTMMTFGKPEEEDSILSLEQSSRVVSLSQLLFIVGQ--KTLVYLEKCEAEFKKRKIEAETRNGKVKNQGADVTNTTQDNGGDKE-LEMIGGTNEDDFTDAIQFVKENELLFGEKSI-LGKFCPIVEEIVSNSSRFSDP------MLQRTATLCLEKLMCLSSKYCEKSLPLLITV------------EKSPDPTIRSNAVLGLGDMAVCFNNLVDENTDYL-----LMTVTFLILALDNPDQGISDMCRLFFTELASK--YNGFIDIFSNLSSDDLDKERHQKQLNEKLVGRLRKCETQKQWDDIA---ALLEQGFKVVSAKE...... 1176
38 -12.700[R] KOG1128 Uncharacterized conserved protein, contains TPR repeats  ali follow..  37................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LITSEYQDNIWEFVESLVTHVLASNNTSSFISEELARQKLSCGLNIPNAVSKSLWALHLAHEHVEKLKDLSDIPPIGYRVILEFYLVWQQLLIDPEE--------TIRTEIEPIMEKL-RVLIAEENDAFTSEDRCQIQLEMAVRFQFYEYDKADNLIKSASEECQLNMDLSGMMGKRTRFQQRDIAQLVLDPSTTGTPLPPDSDIPQSLDMNDDTLLEQVAITRTLNACQLSCLL-RHESATHRHDVLVHERCSPVLDTVIAARRYWSIQAAAL--------------LARAELERGRVRQVDRSCTQSELVVVDDPVLIKDRLLRTSYILASGLGILNSLGCTSEALLILEK--LEMWDGVIDCYKQLGQMDKAETLIRRLI----EQKPNDSMLHVYLGDITRNLEYFTKA----IELSDDRNARAHRSLGHLLLMDKKFEEAYKHLRRSLE----------------------QPIQLGTWFNAGYCAWKLEN---KESTQCYHRCVSLQPDHFEAWNNLSAAYPKAWKLLQEALKYNYEHPNVWENYFSQAIQAYHRLLDMNKRGADDEVLELIAQTLLRREAEISMDESEDKAQNEAENRKEKEEMIKLLARISANHQTSPKTLRVYALLKKPSVLSSETRTEFEKYVRETAVRLAEDRLELA----FIASDTSVKEASAKVRLSLRGILTRLDKDSGSRVSGDETEKLQEIVEVAVAI.......... 787
39 -12.600[R] COG0457 FOG: TPR repeat  ali follow..  280....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IGKLPEKDALDLLKQCGITEEDIQNVLIESSEGVPYYLELSIDIYRKI-----KKKKQPTPENFAKVPEGIFCRFVKYLDREEKETLKVLSVPRYWNRELFKILVEKF--NTGYPATSFSELHSFSFMDVDDKGKCSMHQLMRKSLKDYQDQDLKDIDIKEITPEHEIALTEAFYEAEDLLKWFISVSDPFNRAAFWQLITPMYEEMLQ-------------------------ILEAKHGPEHKDIVTTLNILDVLYYKMGEYKKALQFSERALAIGETILGVQHPDV----------ATSLDNLAGLYESMGN--------YKQALQLSERALEIYEKVLG---------PQHRDVAITLDNLAGLYESMGEYEKALIFYQRTIEIKEKVLGPQHAVLYRQMGEYEKALQLSQRALEIYEKVLGPQHPDIATTLNN------IALLYDSMGDY---------QKTLPLYQRALEINEK-------FGPQYLGIATTLNNLAGFYRRVGD-----YEKALSLSQRSLEIDEKVLGSQHPDVARTLNSLALIYENIGDYEKALAFYQRSLDIREKVLGPQHPDVGRTLNNL------ARLYEIMGDHEKALTLYQRTIEIKEKALGPQHPDTILNNLAGLHYRIG--EYKKALPLYQRALDIVEKKLGQNQ-PNSVVIKNNYNRLLSKMSENE...... 912
40 -12.500[U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4, beta subunit  ali follow..  12  18...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LKAELNNEKKEKRKEAVKKVIAAMTV----------KDVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAK-SQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIR--------------------------------VDKITEYLCEPLRKCLKDEDPYV--------RKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTAL------------------------------------NECTEWGQIFILDCLSNY--------NPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFLELLP-------------------KDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVIQTKVNYVVQEAIVVIRDIFRKYPNDEPDARAAMIWIVGEYA---------ERIDNADELLESFLEGFHDESTQVQLLLTAIVKLFLKKPSETQE-----LVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEVV.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 541
41 -12.400[D] COG3096 Uncharacterized protein involved in chromosome partitioning  ali follow..  170........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SITDYHSLMFDLGIIARRLRSASDR-SKFYRLIEASLYGGISSAITRSLRDYLLPENSGVRKAFQDMNRMTLEAIRVTQSDRDLFKHLISEATNYVAADYMRHANERRVHLDKALEFRRELHTSRQQLAAEQYKHVDMARELAEHNGAEGDLEADYQAASDHLNLVQTALRQQEKIERYEADLDELQIRLEEQNEVVAEAIERQQENEA---------RAEAAELEVDELKSQLADYQQALDVQQTNQAIAALNRAAAEWLETFQAKELEA------EKMLSLEQKMSMAQTAHSQFEQAYQLVVAINGPLAR-------------EAWDVARELLREGVDQRHLAEQVLRMRLSELEQRLREQQEAERLLADFCKRQGKNFDIDELEALHQELEARIASLSDSVSNAREERMALRQEQEQLQSRIQSLMQRAPVWLAAQNSLN--QLSEQCGEEFTSSQDVTEYLQQLLEREREAIV---RDEVGARKNAVDEEIERLSQPGGSEDQRLNA----LAERFGGVLLSEIYD-----VSLEDAPYFSALYGPSRHAIVVPDLSQVTEHLEEDLYLIEGDPQSFDDSVFSVDELEKAVVVKIA-----DRQWRYSRFPEVPLFGRAARESRIESLHAEREVLSERFATLSFDVQKTPEAEIRQLNSRRVELERALSNHENDNQQQRIQFEQAKEGVTALNRILPRLADDSLADRVDE------IRERLDEAQEAARF----------VQQFGNQLAKLEPIVSVLQQFEQLKEDYAYSQQMQRDARQQAFALTEVVQRRA----SYSDSAEMLSGNSD------LNEKLRERLEEAERTRAREALRGHAAQLYNQVLASLKSSYDTKKELLNDLQ--RELQDIDSGAEERARIRRDELHAQLSNNRSRRNQLEK--ALTFCEAEMDNLTRKLRKLERDYFEMREQVVTAKAGWCAVMRMVKDNGVERRLHRRELAYLSADDDKALGALRLAVADNEHLRDVLRMSEDPKIELSRLTEELTSREQKLAISSRSVANIIRKTIQREQNRIRMLNQGLQNVSFTHAMLLDVLSEQHEQHQDLFNSNRLTFSEALAKLYQRLNPQIDMGQRTPQTIGEELLDYYLEMEVEVNRGSDGWLRAESGALSTGEAIGTGMSILVMVVQSWEDESRRL-RLLFLDEAARLDARSATLFELCERLQMQLIIAAPENISPEKGTTYKLVRKVFQNTEHVHVVGLRGFAPQLPETL............................. 1475
42 -12.400[S] KOG1949 Uncharacterized conserved protein  ali follow..  1............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MLLECF--ININYIKKEEGRRF--LSCLFNWNIN--FIKMIHGTIKNQLQGLQKSLMVYIAEIYFRAWKKASGKILEAIENDCIQDFMFHGIHLPRRSPVHSKVREVLSYFHHQKKVRQGVEEM----------------LYRLYKPILWRGLKARNSEVRSNAALLFVEAFPIRDPEMDSKIQKQFEELYSLLEDPMVRSTGILGVCKITEMMPPTILIDLLKKVTGELAF--DTSSADVRCSVFKCLPMIL------------------------------DNKLSHPLLEQLLPALRYSLHDNSEKVRVAFVDMLLKIKAVRAAKFWKICP-------MEHILVRL-------ETDSRPVSRRLVSLI------------LPVNQPEEVWCERCVTLVQMNHAAARRFYQYAHEHTACTNIAKLIHVIRHCLNACIQRAVREPPEDEEEEDGREKENV-KTLSVNDVACMAGLLEIIVILWKSIDRSMENN--EAKLYTINKFASVLPEYLKVFKDDRCKIPLFMLMSFMPASAVP-----FSCGVISTLRSREEGAVDKSYCTLLDCLCS------------------GQVGHILELVDNWLPTEHAQAKSNTASKGRVQIHDTRPVKP--------------------------------ELALVYIEYLLTHPKNRECLLSAPRKKLNHLLKALETSKAD--LESLLQTPGGKPRGFSEAAA----RAFGLHRLSIHLQHKFCSEGKVYLSMLEDT---SKILSFIQDQEEDYLKLHRVIYQQIIQTYLTVCK----DVVMVGLGDHQFQMQLLQRSLGIMQTVKGFFYVSLLLDILKEITGSSLIQKTDSDEEVAMLLDTVQKVFQLECIARSFRKQPEEGLRVSDVEELTPPEHLSDLPPFSRC---LIGIIIKSSNVVRSFLDELKACVASNDIETAAVHIILV---------INAGK---KSSKVREVAATVHRKLKTF---------MEITLEEDSIERFLYESSSRTLGELLNS................................................................................................................................................................................................................................................. 888
43 -12.300[D] COG5657 CAS/CSE protein involved in chromosome segregation  ali follow..  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MDDIPTLLARTLNPTTSKSAEEALKVW--------ELQDSSFALKLLNIVAEDT-NIKLAASLYFKNYIKKHWDSEEGA-DEVAELIKREIINLMLKSTTIIQVQLGEVIGYIANFDFPDRWDTLLPDLISKLSAVDMNTNIAVLSTAHAIFKRWRPLFRS--DALFLEIKYVL-------DRFCEPFLALFVQTNNLLRNGPQDAESLNSLFQVILLECKLFYDLNCQDIPEFFEDHMSTAFLNYFTYTNPSLEGDICEIVELYTLRYE--EVFTMLYDFVNVTWTLLTTLTPDEKYDGLVGKAMAFLTSVIRIRKHAEFFQQDQVLQQFIELVVLPNICLRESDEEDLEGSNSDSRARSAIVLVRGLLDHFDQKITSVVSTHINANLQQFSTNPKKYVALQLFSAIAIKGQSTRLGDVVAFFENNIKPDLLQPAGVIHPMVLAEDIKYV---------------------------FTFRNQLNSQQLIDIFPTILRFLEMPSFVVYTYAAIALDQLLTVRHNH-VHIFTSLLIAPHILPALNQLFLIVESASTPQKLAENYLMKAVMRI----------------------IIMSQEAILPAASLLLQHLTKITEEVSKNPSNPKFNHYLFESIGAL-------------RSLSKSGPQTVSQLENALLPVFQNVLIEDVTEFIPYVLQL----------LSQLVEASGNEPLPDFVVNLIQPCLSPALWDSKGNIPALVRLLRAMIFRGPQIFISNKFVEPVLGIFQKLISSKVNDHF------GFDLLDRVFTVFN-------------------------------------NILAPYINHIFFLLLSRKNSRTERFVLRCTIF-----------------FFFVASEQTGTCGPDNLIQGVDAVQSGVFGQLMTSI--LPQAQKLALPLDRKIS---------LGLLR-LLTCDLVLAPDAIYENLIIPLLTCILKLFEMPIEQA-QTDADEELFMDEIDADSMSFQASFSRLATTGGKRVDPFPQITDLKQYCATEMNLANRNMGGRLSQIISTHLPGDGQSVLQSYGYV................................................................................................................................................................................................................................................................................................................................................................................................... 966
44 -12.300[U] COG5240 Vesicle coat complex COPI, gamma subunit  ali follow..  11  22....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TVTQDARAFNSSSISPRKSRRLLSKIAYLIYTGEHFQEKQATELFFGITKLFQHKDPSLRQFVYIIIKELSVV---------AEDVIMITSSIMKDTATGRETIYRPN--AIRSLIRVIDANTVPAIERILTTGIVDPISAVASAALVSAYHLYPVAK----DIVSRWNNEVQDAVTSH-----ASSPFFTSTLGYTPNASISQYHALGLLYRIRRHDSIAMNKLLQLLVSNLGTVSNSHAFVMLIRYISSLMDQNTQFRDQMVPF---------LHGWLKSKGDMVNLEVARNM-KNISDDDLQPVVSVLKIFLSSHRSATRFSAIRTLNELAMTR--HLVHSCNLNIESLITDVNRSIATYAITTLLKTGN--DESVDRLMKQIVTFMSDI--SDNFKIIVVDAIRSLCLKFPRK-----QDSMLTFLSNILCDEGGEFKRAAVDAISDMIKYIPESKERALAELCEFIEDCEYPKIAVRIEEGPKASEPTRFIRYIYNRIMLENAIVRSAAVSALTKFGLNAE------------DKFVQRSVKVILTRCL--EDADDEVRDRAAFSVKAL............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 557
45 -12.200[S] KOG4814 Uncharacterized conserved protein  ali follow..  3............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FKEVVENLVTNDNSPNIPEAIDRLFSDIA-----------NINRESMAEITDIQIEEMAVNLWNWALTI-VNEEQKIRLHYVACKLLSMCEASFASEQSIQ-RLIMMNMRIGKEWL--------------DAGNFLIADECFQAAVASLEQLYVKLIQRSSPEADLTMEKI-TVESDHFRVLSYQAESAVAQGDFQRASMCVLQCKDMLMRLPQMTSSLHHLCYN-FG-VETQKNNKYEESSF-SQSYDIGKMDKKSTGPEMLAKVL-RLLATNYLDWDDTKYYDKALNAVNLANKEHLSSPGLFLKMKILLKGETSNEELLEAVMEILH-------------------------------------------LDMPLDFCLNIAKLLMDHERESVGFHFLTIIHERF---KSSENIGKVLILHTDMLLQRKEELLAKEKIEEIFLAHQTGRQL-------------------------------------TAESMNWLHNILWR-----QAASSFEVQNYTDALQWYYYSLRSTDEMDLDFTKLQRNMACCYLNLQQLD----------------------------KAKEAVAEAERHDPRNVFTQFYIFKIAVIEGNSERALQAIITLENILTDEESEDNDLVAERG------MLLSLAAQFALENGQQIVAEKALEYLAQHEDQEQVLTAVKCLLRFLLPKIAEMPESEDKK-----------KEMDRLLTCLNRAFVKLSQPFGEEALSLESRANEAQ----FRKTAWNLAVQCDKDPVMMREFFILSYKMSQFCPSDQVILIARKT-AVAVDLEQGRKASTAFEQTMFLSRALEEIQTCNDIHNFLKQTGTFSNDS-------CEKLLLLYEF-EVRAKLNDPLLESFLESVWELPHLETKTFETIAIIA-----------EKPAHYPLIALKALKKALLLYKKEEPIDISQYSKCMHNLVNLSVPDGASNVELCPLEEVWGYFEDALSHISRT-MEILWLMVKSWNT-SAEKWCGLALRFLNHLTSFKESYETQMNMLYSQLVEAL-EHGYW-----SKSD....................................................... 917
46 -12.000[R] KOG1129 TPR repeat-containing protein  ali follow..  2.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QCLSDSTYVDELENEDMGLAETFLDQNVIAPNARPGTSFARPKTSAKGVNPILRPTTNAGRPLS-QSSFKSGSMDQAVRTARTAKTARAVSSTSNMRLGTASMAAGADGEFVNLARLNIDKYAADPQVNRQLFEYVFYYLNDIRVAHQIAGTAEDYYWKNQLAKCYL------RLGMLQDATKQLQSSLEQKKLIETFALLSKAYNRVDQPAALKTYSAGLEVFPENVTMLTG-----MARVQEALGEYDESVKLYKRVLDA---ESNNIEAIACVATTYYYGGKPELAMRYYRRILQMGVPELFLNIGLCCMAAQQFDFALSSILRAQS--------------------MTDDVAADVWYNIGQILVDIG--DLVSAARSFRIALSHDPDHSESLVNLGILKHRE-------------------GKIDEARSLYSSATSKN--------PYMFEGNYNLGLVSFTQGK---------------HECRELIEKALAAFPEHEHCKKILNHLKPLYESI............................................................................................ 458
47 -12.000[R] KOG2220 Predicted signal transduction protein  ali follow..  11.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KPSEVDVIKPLNNLIQSTY--GASEEEKGKYGEAVNEFQRNTAIWKFFEKYEASLEIVYA-YYDQICALETKISVSELQIPFKWKDAFDKGSIFGGKISLTHTSLLYEKVCVL------------------FNIAALQSNIAANQSLDSDDGLKLTIKLLQQIFQYLK--GATPAAVPSEPTPDLSQDTLTVLQALMVAQAQEVFILKAIKDNLKDQIIAKLCCQAEES--YADVLRAMQKESVRSLWEKEWIPTIAGKQAG----FHALTQLLVCRAAKKIGEEIARLRNAFKAAQTRSGNETYLDEYFSRAKRNLTESTKDNYNEIIPELSTLTSPGELHRALTASDMRRNEIVNVEIMKLREATQTLNAVLASLNL--AAVETADGNSGLPPSLKEKANEVRQKGGIENVQTMLKDLPEL---------------LNRNREILDETERLLDEERDSDNQLRAQFKDRWTRISSDKLTEMFRTNAKKYREVITNAIEAD-----KVVRQKFEANQKGIQLLSLPPDQIQQSLPSASGSVDPNCSSVQR-------------------LKKLMDDVETIKAEREAIESELKGATFNMKDEFLIALQKDGAIDEPALSLARIGQV---------LNPLQQQVRESVERQQSLVSEI---------QSAHGAFVSETGSCGSSRDTLYQELATAFDSYIELSGNLQEGTKFYNDLTQLLVVFQNKISDFVFARKT 700
48 -11.900[D] KOG1126 DNA-binding cell division cycle control protein  ali follow..  19.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DNSIFYSERLHAIEDSLLAYSHFLNLDYNIVYDLLD--------RVISHVPCTYLFARTSLILGR-QGISAVEACRSNWRSIQPNINYKKAGFLKKATDCFVEAVSINPYNFSAFQNLTAIGVPLDANNVFVIPPYLTAMKGFEKSQTNATASVPEP-------SFLKKSKESSSSSNKFSVSESIANSYSNSSISAFTKWFDRVDASELPGSEKERHQSLKLAFNDAQKADSNNRDTSLKSHFVEPRTQALRPGARLTYKLREARSSKRGESTPQSFREEDNNLMELLK--LFGKGVYLLAQYKLREALNCFQSLPIEQQNTPFVKLGITYFELVDYEKSEEVFQKLRD----------------------SPSRVKDMEVFSTALWHLQKS--VPLSYLAHETLETNPYSPESWCILANCFSLQ-------------------REHSQALKCINRAIQLD--------PTFEYAYTLQGHEHSANEE------------------YEKSKTSFRKAIRVNVRH--WYGLGMVYLKTGRNDQADFH-----FQRAAEINPNNSLITCIGMIYER-CKDYKKALDFYD.......................................... 557
49 -11.900[DO] KOG4322 Anaphase-promoting complex (APC), subunit 5  ali follow..  11  26................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IKDWVTPVLLNEMSRTGEGAVSLME------------RRRLNQLLLPLLQGPDIT--LSKLYKLIEESCPQLANSVQIRI--KLMAEGELKDMEQFFDDLSDSFSGTEPEVHKTS--AYSKLSFSQVFKLYTALQQYFQNGEKKTVELSQQASLLKNDETKALTPASLQKELNNLLKFNPDFAEAHYLSNNLRVQDVFSSTHYFDRLILTGAESKSNGEEGYGRLAALHCRFGHYQQA--------ELALQEAIRIAQESNDLQHCLSWLYVLGQKRSDSYVLLEHSVKKAVHFGL-KTANKLMDALKDSD---RSTMALQQAQMLLSMNSLEAVNAGVQQNNTESFAVALCHLAELHAEQGCFAAASEVLKHLKERFPPNSQHAQDGKYHLADSLVTGITALNSIEGVYRK-------------AVVLQAQNQMSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIALPMLLQALALSKEETVLNLAFAQLILGIPEQALSLLHMAIEPI---------------LADGAILDKGRAMFLVAK--QPKKAEALEAAIENLNEAKNYFAKVDDVVYFQARLYHTLGKTQERNRCAMLFRQ............................................................................................................................................................................................. 739
50 -11.900[R] COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain  ali follow..  165......................................................................................................................................................................................................................................................................................................................................................................................................................................................................KKFLITQIAAKLGQIIRIHLSDSTDPKMLIGTYTSPKPGEFEWQPGVLTQAVITGKWILFTNIEHAPSEVLSVLLPLLEKRQLVIPSRGETIYAKGSFQMFATSSMWQILDLTYQPDECVEVVSTLYPVLSIICPTLYSVYKDIFDLFSQRSFLATSKIYRRLCLRDFYKFIKRVAFLYHKFMIPSDHVVISQAFIPSRDGFDLVVRNVAIELNIPPEKALQLRYSIPVFQNLEHNINIGRCSLKKLSTIRSCSTNSYAFTSSSLGLLEQLA---------AGVQTNEPLLLVTGKTTTIQLLAGLLGQKVTVI-QTESSDMLGGYKPINASTLGLPLHERFIDIFEQTFSSKKNAKFISMASTSARRKTCLKIWKEACKLSKTVLDGQQPLPNPQKRQKRLSNQVELRNQWAKFEKEVEDFEKVLTGGSNGFMFSFVEGALVKAVRSGHWVLLDEINLASLETLEPIGQLLSSYE---TPHKNFRLFGCMNPSTDVGELEPSFRSRFTEIYVHSPDQNLDDLLSIIQKYIGSLCIGNEHVIREVAEL-YQVAKSLSLDGSLVDGAGQRPHYTVRTLSRTLSYVTEIAPIYGLRRS--LYEGFCMSFLTLLDHTSESLLYNHVVRFTLG--ELNRDQQNAILKQIPKVPDHSSYIAFCHYWLRRGSFPVEEQEHYIITPFVQKNLLNIARPILIQGPTSSGKTSMIEYVAKKTGHKFVRINNHEHTDLQEYIGTYVTDDNGSLSFREGVLVEALRNGYWIVLDELNLAPTD----------------VLEALNRLLDDNRELFIPETQVLVKHPEFMLFATQNP--------AGRKHLSRAFRNRFLEIFDDIPENELETILHKRCKIAPSYAAKIVQVFRE----------------LSLRRQTTRIFEQKNSFATLRDLFRWAFREA-----------VGYQQLAENGYMLLAERARDQKDKLAVQEVIEKVMKVKIDTDGIYNLDSMEIFQDMSLKEGPLSKVVWTRPMIRLFCLVWRCLLAKEPV---LLVGDTGCGK-TTVCQILAECLHKELHIINAHQDTENGDI--IGAQRPVRN--RSAVNYSLHSQLCEKFIDDLIEKFEKLSSSEKNDNLSNLIERQIIKYRSLFEWHDGALVT--AMKQLDEISLADDSVLERLNSVLELSRTLTLVEHSNAAVSLTAKDGFFATMNPGGDYGKKELSPALRNRDTEDILKIVEGKLHNNKIELARPLVEYAKWHANEYLYTDVISIRD---------VLSAVEFINACEILDLNLVLFNAVSMVFIDALGSFTTFSLSNNLASLHAERQR--KFSDSSFFIGD-----FGIPLGDSVESDSTYSLHTDTTLMNASKVLRALQVLKPILLESLITALARETGHQLVRINLSDQTDLMDLFGSDVPVEGGEGGQFAWRDAPFLAAMRNGHWV-----LLDELNLASQSVLEGLNACLDKVFKAHPNFRVFAAQN--QHQGGGRKGLPRSFINRFSVVYVEALKEKDMIEIAACNEDWRLKIIKF.......... 1735
51 -11.900[U] KOG1062 Vesicle coat complex AP-1, gamma subunit  ali follow..  11  4.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FSSGTRLRDMIRAIRACKTAAEER-CADIRALINEDDPHDRHRNLAKLMFIHMLGYPTH-----------QMECLKLIASPGFPEKRIGYLGLMLLLD-ERQEVLMLVTNSLKQDLNHSNQYVVGLALCALGNICS----------AEMARDLAPEVERLIQFRDPNIRKKAALC---STRIIRKV-----PDLA----ENFVNAAASLLKEKHHGVLITGVQ-LCYELCTINDEALEYFRTKCTEGLIKTLRDITNSAYQPEYDVALHIRLLRLLRDADASDLMTDILAQVATKTESNKNAGNAVLYECVETIMAIE--SLRVLAINILGRFLSNRDNNIRYVALNMLMKAITFDDQAVQRHRVTILECVKD--PDASIRKRALELVTLLVN-------ENNVTQLTKELIDYLEISDEDFKEDLSAKICFIVEKFSPEKLWYIDQM--------------------------------LKVLCEAGKFVKDDVWHALIVVISNAS---------ELHGYTVRALYKSV-----LTYSEQETLVRVAVWCIGEYGMLGIEDPITVTESDAVDVIEDAITRHNSDSTTKAMALVALLKLSSRFPSISER------IKDIIVKQKGSLLLEMQQRAIE-----YNSIVDRHKNIRSSLVDR.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 589
52 -11.800[U] COG5308 Nuclear pore complex subunit  ali follow..  94................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ASEFVQDLSFRDRNTPILDNPDYYSKGL-FQRQQVTNIPDEVLSQVSNIFLELNYCWITSDNKLILWNINNILKVKLVKPSPNTFVSSVENL--------------LIVATLFDI---YILTISFNDRTHELNIFNTGLKVNVTGFNVSNIISYERTGQIFFTGA--VNVWELQYNCSENLFNSKSNKICLTKSNLANLLPTKLIPSIPGGKLIQKVLEGDAEEETISQLEVDQSRGVLHTLSTKS------------VRSYLITSNGLVGPVLIDAAHIRRGMNAL----------------------GVKNSPLLSNRAFKIAKIVSISMCENNDLFLAVITTVRLYFKGSISRRSIGSLKEQNKSFIIGHHPLNTHDTGPLSTQKASSTYINTTCASTIISPGIYFTCVRKRANSGELSKGITNKALLENKEEHKLYVSAPDYGILKNYGKYVENTALL--EIKEIVPLTRSFNYTSTPQGYANVFASQYSAEPLKVA--VLTSN----ALEIYCYRTPD--------EVFESLIENPLPFIHSYGLSEACSTALYLACKFNKSEHIKSSALAFFSAGIPGVVEIKPKSSRESGSVPPISQNLFDKSGECDGIVLSPR---GSALLITRWEERVFVFKRASKTEKMDAFGISITRPQVEYYLSSISVLADFFNIHRPSFVSFVPPKGSNAITASDAESIAMNALILLINSIKDALSLINVFYED--------IDAFKSLLNTLMGAGGVYDSKTREYFFDLKFHDLFTPNAKTKQLIKEILIEVVNA-RAGEHLEAAQKFEMIDSKISRNHLDTAIDLYERCAE-CELRRVVDIMVKLNYQPKTVGFLLRFADKIDKGNQAQEY--SRGCNTADPRKVFYDKRINVYTLIFEI-----VKSVDDYTSIEQSPSIANISIFSPASSLKKRVYSVIMNSNNRFFHYC---------WLVANKRQDYLLRLDSQF---VLPYLKERAEKSLEISNLLWFEEHFLEAADVLYALASS------------DFDLKLSERIECLARANGLCDSSTSFDQKPALVQLSENIHELFD-----------IASIQDDLLNLVRNETRIDEDYRKQLTLKLSDLFNDCADPLDYYEIKLFKDEKVIQGEWNRLLDSMKNAPSPDVGSVGQESFLSSISNTLIRIGKTTRDTDVVFPVHFLMNKILESFIDKSSAADG----VCSMFLLAGVSH-LKLYYILSRIIENSEGNVELAKKEMVWLIKDGSIAPEQIKKLEKYDPNTDPVQDYVKDRHHG....... 1389
53 -11.700[U] KOG2081 Nuclear transport regulator  ali follow..  6.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VDVVYQAISALFQGNNPKEQEKANKWLQDFQK------SIYSWTIADELLHQKRDLHANYFAAQTMRNKIQELPPHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAVADLALLMAS--REPINDL-----------LVTLAPHQCAIWPLLEVLKVLPEEIDSRYLRLGANRREEVHKQLDAS----------------AECVLKFLCMCLQREDLDQQRVWNAALRTYSA----------------------VIHAFPVSHVYNNALTQLAFRLLSLPETSGKLHDNATECVCALLSCINTRQDGASDPESS------------FEAQLFGAVCMLETPYHLSVAHEDTDKTINYCRIFTSLCDAFFYDLLADAQKPHYLKGLDLVLLCVGHFDYEVAEITFHLKLSEDLFQRNEDKLTVLFRPHIERL-------------------ISALFRHSQM----------------------SDHDGLIEENNNFFDFRRKVSDLIKDV-AFIVGSGAC--------FKQMFHILQAPETTWESTEAALFIMQNVAKNILPDENIPKVVEAILNMSEQTHIAVRYTA----LLIGELCDWIENHPESLEAVLNFL--LYALQQKNGLAPAAAIALTSICSACRQKMVCHISGLVEIAR-SLDSFQINNDVAIGLLKGISLILTRLPREQLQPALREIVGFQLQPLAQLVDSTGSTPQKGERTDPVYW--IDRACAIIRHTNPDVPD----------------NVEHPTVAILNDAWQLI---SRVMDKYQSDLRIMERTCRLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQHHSCFLYVG--------------------------------------------------SILVDEFAKSSECIGGLLEMLQAFIEPTFGLLQMENGL--KNNPDTLLQSSLITPIFQCALIACSLDHREANSSVMKFFINLLVWGRSNNHSRNT---------------ECRPLVVELASQHGGAL--------VMNLIQASVFQHSYMLVDVAEVLHELKQVVGNERM-ALEALPKKNSGGYVTATQQQLDEFSSTVLRADTTKAISQALKTFTRLFR............... 914
54 -11.600[S] KOG4648 Uncharacterized conserved protein, contains LRR repeats  ali follow..  10  1................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MTSANKAIELQLQVKQNAEELQ----------DFMRDLENWEKDIKQKDMELRRQNGVPEENLPPIRNGNFRKKKKGKAKE----------SSKKTREENTKNRIKSYDYEAWAK-----DVDRILDELDKDDSTHESLS--QESESEEDGIHVDSQ-NKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGA-ARFALQKLEEAKKDYER---------------VLELEPNNFEATNELRKISQAL---------ASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGI----AADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSKAFARRGTARTFLGKLNEAKQDFETVLL---------------EPGNKQAVTELSKIKKELIEKGHWDDVFLDSTQRQNVVKPIDNPPHPGSTKPETGNLIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKNSSQDVLFPTSDTPRAKVLKIEEVSDTSSLQPQASLKQDVCQSYSEKMPQLKSSPDMLYQYLKQIEPSLYPDVFNQIVKILHD-PLLIFEILQRL----LKRFDMAVMFM--------SETEKKIARALFNHIDKSGLKDSSVEELKK......................... 661
55 -11.600[Z] COG5022 Myosin heavy chain  ali follow..  84..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LNEPSVLDALSTRYNQLQIYTYSGIVLIAVNPFQRLPNLHEIVRAYSEKSRDELDPHLYA------------------------IAEDSYKCMNQEHKNQTI--IISGESGAGKTVSARYIMRYFASVQALIQSTDSNFHEAPQLTAVENEILAIMEAFGNSKTSRNDNSSRFGKYIQIL-FDGNATIIGAKIQTYLLEIFYQILAGSSSEQLEKWKLQEFNYLIEGVNDKEEFKATVDALKTV------IDNDTCECIFSLLAALLHIGNIEVKHSRNDAYIDSKNENLINATSLL-----GVDPSSLVKWLTKRKIKMASEGILKPLN--EFQAVVARDSVAKFLYASLFDWLVATINKALMYSADKSNQTAKSF----------IGVLD-----------EHFKKNSFE------QFCINYANEKLQQEFYRHVFKLEQE--EYAAEGL-----------------------WSYIDYQDNQQCISMIESRLGILSLLDEECRMPTNSD--------ENWVSKLNDAFSKPEFKNSY-------QKSRFGNKEFTIKHYALDVVYCAEDKNRDTISDELLELFTNSDTAPPADTKKIKTKPKSNTLGSMFSSLVSLMSTINETNAHYIRCIKPNEEKEAWKFDNQMVVSQL-RACGVLETI----ISCAGFPSRTFDEFVSRYYMLVPSAVRTTESLTFSKAILEKIFFR----SGVTPLLESARDKALKHAAHLLYEAFAVNYYRTRFLLSRKRVRSFQAVAHGFLEYELLSSNIIKLQSLWRTALKRKEFIQTKNSILKVQSIIR-----LLRQTLEEKTKHDATLIIQSLWLTFKAHKHYKELQYYAVRIQSLWRMKLAK---RQLTELKIESTKASHLKQVSYRLESRLFEISKQLDNSEQENNKFRERIAELESHLSNYAEAKLAQERELEQTRVLISDQSQDGELKELLEEKENALIMMEEEMRQVNDANTELLRVNATLKSQLKNYDMIIVEQTSQLKEKNRIIASLTKATKILNSASSAKLLFCQESVALVERYCVHTLEYVFQKTSSANERPDIGFWVANTHALLFVYTKQQAFKHSSAFTLLSTESHESVQTIFEMIESHLSKIFFEWVRQVNNFLK--ITGTNTDAGDENRKLRIKFFEKPKYKITDVIHVLNKVHDSCQAYIYNALIRSIYRFIN------VEAFNSLFIDERGSWKSYNYHVLKDWCLESGVPEAYLQLEELLQTSKILQFVKDDPNYVARVRDFYALNLQIKTLLHRYDYAD.. 1411
56 -11.600[YU] KOG1993 Nuclear transport receptor KAP120 (importin beta superfamily)  ali follow..  10  4..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DPVVYQLQRAVS----------------QDPIAVKDAEGHLNNWKKEPGFFGKLYSIFLD-KQNDMSLRWIAIIQLRNSIDIIRKNTKMSLLPEERDFIRCNALLGSI-------KSENLLSIQNALVVSRIARLDPTEWP---------------------------LFHDLLGKLQQSLGTGDYDVALRLLITLHHIIK-----AMAGNRLLRSRQIFYKLAPELLTILQPILHS--------------------------SLSSWMMILESSKEIKDSTLLSYMQISR------YTLKACRRLVVFGFQNPSESELAFCAVHQRKLLSMLGTMLQSSRSPIVVG-------ECLEMAFAHAFLFNKPFFDFSFYSPCLTKFPATIDYISLHYDFLGQISSHLSSYKEKFEESSKNFEKLVIMSLRVFILVIQEFCNTKSSHPETAQ---VLYNSFLVDNRINNLLDLLITKLLI---LKEEDFEEWTDSPQQWQSTQDVEFNVRPCAEKLLKCFFDAYGDIIVSPFKDMIYSVFECPKTLTQAVQQDTLISS---TQLKSIF------PFAKWLQEAAVPNMASINDIGISRVYREQLLEVIYKLYCSFLNLTDPCNDAVVILTTIDAFKTVLDDWNFSENSFLS--------------IKENLFVHVLSLFKAFESVDARTSILSLLGTLLARAGEHVAPMESTI-----------ASLLSQLWDGWKKERVLAVMHQFVN-------------AIKAKSFEFSTFLYTVIEYCVNPESPEHVIFEADAMELWSTFLMYIQKLPETFTLLIPHLLYHLSQATSTLPF-----------VLMIVSSYQLLMKDYSFTIFEKLNDLLD--------------------------DVKNETLQALCKTVCLLIETTPMDMI-SLLSRLLLSIATNDKHVLIEYLLVVSRISLREPELILKVCQTKNINHSKDRKLNTLALSSLLRTNHPDVL--AVLDSIMNLWFSVLSEVEE........... 896
57 -11.500[R] COG1204 Superfamily II helicase  ali follow..  10  554......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LCILNELQKHLREDLSFNLQNFKIVYIAPLKALVQ-YNIRVAELTGDSQLTKQQ-ISETQIIVTTPEKWDIITRKANDLSYVNLVRLVIIDEVHLLHDERGPVLESIVARIFRHQEETLEQVR---ATLPNYTDVASFLHVDPKKGLFYFDSTYRPCLKQEFIGITEKTPFKRMQTTNEACYEKVMQHAGKNQVLIFVHSRKETAKTARFIRDKALEEETSDENLKDLLPYGFAIMRREDRQTSEDLFADGTIQVLVSTATLAWGVNLPAHTVIIKGTQVY----SPEKGIWTELSPQDVLQMLGRAGRPQFDTYGAHSELQYYLSLESQFMRRLADCLNAEVSLGTVRSIELRSPALGPEYDDDKYLVQKRADLLHSAQTTSFIELFRVFSFSVREEEKVELAKLLPAAKINALLQSYVADMVYVTQSAGRIMRAIFEISLRRGWSSVATLSLDTCKMIEKRL--WPTMSRRVEKKEFPWQRYFDLDPAELGELVGVPKEGRRVYNMVQSFPRLSVEAHVQPITR-GDRLLHYEQFFLLKKYKDDEHIVNFPSFISLYPNFKFFNKIQTQVFNSVYKT-NDSVFIGAPNGSGKTVCA---------------ELALLHHWSQEDYGTAVIAPIQEIVDRREEWYGKFSDLGDGK--------VLVKLTGERSQDLKLIQVADLIFCTPSQWD--------------------SLSKRWRSMRSIQKVDFYICDELQLLGGFYGPLYEIVIS----RIRYMAVQLEKNIRVVGLSVSV----ANARDLGE-WLGTSPQCLMLAMSKPIYRSLKNFISQRKSTIVFTPDR----KVAKQLAFDLVTFSMAD--EDEYLFSLMENEAFNKVEDAALQQSLKHGIAYISEITSSNDQNIVQYLYRHIVMGTQYYDGKEHRYIDYPISELLQMLGFTASIGSSELSQVILMTVKKEYYKKFLN--ESHLQVWLHDAFVSWLTWSYMYRRLVANPAYYGLQDITHESVSEFLSDL---VETTMNDLSEARLITCVALNLAMIASHYGITYITMQTFALSLSERTKMKGLLEIVTSAAEYEQLPIRKYEDLAAHFSRFELPPGLVIDQKFILTRVHNLLGACVDTL......... 1966
58 -11.500[V] KOG0624 dsRNA-activated protein kinase inhibitor P58, contains TPR and DnaJ domains  ali follow..  10  33...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GSQFLARAQFADALTQYHAAIE------------------------DPKSYQ---------AIYRRATTYLAMGRGKAAIVDLERVLELKPDFYGARIQRGNILLKQGELEAAEADFNIVLNHDSSNNDVQEKTAIKSAYAGGDCATVEEYINHIQVWDASLYRMRA-KCLEERGELKKAIHDMRIV------KLSTDSTDTMFETSKLLYTVESLNVIRECLKLNPDHKSKKLRKVVKSLESMKKKVENSDACLEEGQKTMKFDPTPSVQLNVFRITNRCQREAGHISEAIAECNEILNDDPSDILCERAEAHILDEDYDSAIEDYQKATEVNPDHREAKEGLEHAKRLKTQAGKRDYYKIL-ITKAYRKLAQKWHPDNFSDEEEKKKAEKKFIDIAAAKEVLQDEEKRRQFDQGVDPLDPE............................................................................................................................................................................................. 453
59 -11.400[Z] KOG1840 Kinesin light chain  ali follow..  10  77.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DEVAKPEEFDVKSNSSNLDLEVMPRDMEKQTGKKNVTKSNVGVGGMRKKKVGGTKLQNGNEEPSSENVELARFLLNQARNLVSSGDSTHKALE------THRAAKLFEASAENGKPC--EWIMCLHVTAAVHCKLKEYNEAIPVLQRSKFAGLMQLGDTYAMVGQLESSISCYTEGLNNDPRVGETCRYLAEALVQALRFDEAQQVCETALSIHRESGLPGSIAEAADRRLMG-------------------------------ETKGDHENALEHLVLASMAMAANGQESEVAFVDTSIGDSYL------------------------SLSRFDEAICAYQKSLTALKTAKG--ENHPAVGSVYIRLADLYNRTGKVREAKSYCENALRIYESSGLTDISVICESMNEVEQAITLLQKALKIYADSPGQKIMIAGIEAQ-------MGVLYYMMGKY---------MESYNTFKSAISKLRA-KKQSTFFGIALNQMGLACIQLDAIEE------------AVELFEEAKCILEQECGPYHPETLGLYSNLAGAYDAIGRLDDAIKLLGHVVGVREEKLGTANPVTEDEKRRL------AQLLKEAGNVTGRKAKSLKTLIDSDLTSSSAL...................................................................... 649
60 -11.400[O] KOG0550 Molecular chaperone (DnaJ superfamily)  ali follow..  1................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MTEVETTMNAGTESQQEPAELAE-KQKAIGNAFYKEKKYAEAIKAYTEAIDLGSDSALAYSNRAATYMQIGEFELALCDAKQSDRIKPDVPKTQSRIR-QAYEGLSILNEAEVYLKNKQAGLALNALDRLQRRIDSTTQQNDMDRAQKIAHDVL--RLNPKNVEALVLRGKVMYYSKAITHFQEALKLDPDCTTRKLENTKNQGNDLFRQGNYQDAYEKYSEALQIDPDNKETVAKLYMNRATVLLRLKRPEEALSDSDNALAIDSSKGLKVRAKAHEALEKWEEAVRDVQSAIE--------------LDASDANLRQELRRLQLELKK---------SKRKDHYKILGVSKEAT-KKAYRKLAYHPDKNAGNLEAEARFKEVGEAYTILSDPESRRRFDSGVDLEPGM..................................................................................................................................................................... 420
61 -11.400[K] COG2909 ATP-dependent transcriptional regulator  ali follow..  3............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IPSKLSRPVRLQNTVVRDR-------LLVKLSSAANYRLTLINC--KTTLIAQWAADQSNLGWYSL----SDNQSERFATYLIAAIEALSQKHQYANLSALFSQLFIELSNWDGPLYLVIDDYHLITNDAIHEAMRFFLRHQPENLTLI---------LSRTLPSLGIANLRVRDQLLELGMQQLAFNHHE----------AQQFFECRLSSPLEQGDSSRLCDEVEGWVTALQLIALSSRQPNSSAQKSAKRLAGLNASHLSDYLVDEVL-------------DQVDSKARAFL------------------RCSVLRSMNDALIVRLTGEDNGQQLLEELERQGL---FIHRMDDSAEWFATFLRQRCQWELALELPELHHAAAEGWMALG------YPAEAIHHALAAGDVGMLRDILLQHAWSLFHHSE---------------------LALLEQCLTALPYPLLVQNPELALLQA-------LAQSQHRYSEVNTLLEQAELAMQERKIPVDEILRAEFGALRAQVAINAG---KPDEAEKLATDALKYLPMAHYY------SRIVATSVTGEVHHCKGELARALPMMQQTEQMARRHEAYHYALWEILIAQGFLQAAYETQEKAFELIREQHLEQLPMHEFLLRIRSQ-------------------------VLWSWSRLDEAEEAARKG----VEILANYQPQQQLQCLAMLAKCSLAR---------------------------GDLDNANVYIQRCEALQHGSQYHLDWITNADKPRVIHWQMTGDKVAAASWLRQTEKPGMADNWRNIARVQIILGRFDEAEVVLDELNEN---------------ARRLRLTSDLNRNLLLSNTLYWQTE--RKGEAQKALIESLTLANR------FISHFVIE-------------------GEAMAQQLRQLIQL-NALPELEQHRAQRILKDINQHHRHKFAHFDEIFVDKLLTHPQVPELIRTSPLTQ-------------------QVLGLIYSSNDQIANEL--VAATTIKTHIRN-LYQKLGVAHRQEAVQQAQRLLQMM.......................................... 900
62 -11.300[U] KOG2376 Signal recognition particle, subunit Srp72  ali follow..  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAPKSKENPKTSTPAIEDLFTSLHKHIKDTKYEEAVKVADQVLSIVPTDEDAIRCKVVALIKDDKFDDYLIKDVKINGALSVINSFPIDLGFHKAYRENKLDEALVCLKGLERESKTLLLEAQI--LNCLGKVDACVDVYQKLASQVLESLKIRPTTTYQLAYNTACSLIENSNYVDAEQL-----------LLTAMRIGQETLTEGD---------YSDDYIETQLAPISVQLAYVQQVLGQTQESKSSYVDIIKRNLADESLALAVALKGSKDISDGLRKFDLLKDKDSQNFQLSQELDAKLSHKHKEAIYANRVLLLL-------HANKMDQARELCATLPGMFPESVIPTLLQAAVL-ELLGQCAENFPEKSKLVLLARAQIAASASHPHVAAESLSKALRERAGDVLDSAIRWWSDSMTDSNMLRILMPVAAAFKLRHGQEEEASRLYEEIVKNHNS----DALVGLVTTLARVNVEKAEAYEKQLKPL----PER--W-LPRRERSSYRPKRKDKRAAQIRGSQGALTKVKQEE............................ 619
63 -11.300[L] COG1330 Exonuclease V gamma subunit  ali follow..  1........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MFTVYHSNQLDLLKALTTALIEREPLDNPFQQEVVLVQSPGMAQWLQMQLAQIAANIVFPLPATFIWDMFTRVLPKESAFSKEAMTWKLMWLL--------DLLENPLFSPMKRYLSDDGDRRKIHQLAARVADLFDQYEWLESWERGQLIEGLDDAQQWQAVELTRYTRQLEQPEWHRANLYQRFIHQLLKSDVCPQGLPKRVFICGISALPPIY--------QALQALGKHIDIHLMFTNP---GDIQDYTFLAKLQSRKRRHYRESIELSLFRHPQQAEQLFNTDGEQNLSLLASWGRLGR----------------DHMYLLSQIDEIQEVHAFVDIEPDNLLHGIQHDMLELEDHAVIGTTPETLARSDQKRRLDLDDRSLSFHVCHSPQREVEVLQDHLLGL-MVVDIDSYTPYIQAAFGNAPSERYLPFAISDRKASQAHPALHAFITLLDLPQSRFTAEQVLLEVPALATKFG---------ITEDGLRRLRQWVGESGIRWGLDDDNVR--LLGYAMDSTAGDWQGILPYDESSGLAAELAGQLADMLMHLSQWRQQLGQPREPICRQLLDTFFDQDNDTEAALVLIEQQWQKVIGYGIAAQYPDVVPLNLLRDELAARLDNLAGPINFCTLMPMRSIPKVVCL-FDLMAKKVRRGDRSRRDDDRYLFLEALLSAQQQLYRSIQDNSKRYPS----VLVSELIEYVAQEKLSADDSAQRVTQHLLCWHARMPF-ELQSYAAEWLPSAESKGHAHPNFNQPLQAEPLAEITLDELVRFYRHPVRAFFQ........... 851
64 -11.200[U] KOG1058 Vesicle coat complex COPI, beta subunit  ali follow..  1..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MSSGEQPCYTLIHVPSDAELPSEAQLKEKFEKGGDKERIEALKKLIYMILNGEKTSQSMLMYVI-------RFCLPSNEHTLKKVLLIFWECVPKTDSNGKLLHEMILVCDALQHPNEFVRGSTLRFLCKLRE-------ELLEPLMPAIRACL--------------------HRHSYVRRNAVCAIFTIY----------------KNFEFLIPDAPELVTEYLEQEQDASCKRNAFMMLLHVDQARALDYLSGCIDQ---------------------------------------------GSFGDILQLVIVELIYKV--------CHNNPNEASRFIRCVYNLLQSSSPAVRYEAAGTLVTLSNV--------------------------------------------PAAVKAAASAYIDLIVKESDNNVKLIV-----------LDRLVALRGSSSNEKILQGLVMDILRVLSSPGLEVRKKTLSLALDLVSS-----------RNVEDMVMFLKKEINKTATESNDENGKYRQELVKTLHAATIVP-EFLSDTNEKASSYVLQFVREAVHKLPNLKNAILGALREGIPFIQSPTIFMSALWILATY-------CEADGALDVLKLVKNSLGELPLVDSELSGQEEQKPEEQQPEQQQKQKPKVTADGT---------TQTALSSTVTTSKKNEKPPLRRFLLDGEFFLGASLATVLTFTELNGAASERANRFRAECMLILSSIIHLAKSGLCIVHQQVNEDDLDRMGATIKILAQGIPGLDEQYGDDCKKSLELMLGAKSISRLDVTTEKMASTTAA------GYRSKDFVEIDKTINFTQLSARSNQQGENLFDLSLSQALGTAPKAQKFDFSSSKLGKVIQLAGFSDPIYAEAYVNVNQYDIVLDVLIVNQTSD------------TLQNVSLELATVGDLKLVDKPTPVTLAP------------DFSNIKATVKVASTENGVIFSTISYDVTGSTSDRNCVYLQDIKIDIMDYIGNVTDTEFRTMWSDF-------------------------EWENKVNVMTPIRDLRDFLNHLSTSMKVLTGDAAIEGDCGFLAANLCAHSGEDALANVSVEKALPMDDSSPIVGHIRI---RAKSQGMCLTLGDKLSSAMRSRRDGQPIAAPSA....................................................................................................................................................................................................................................................................... 971
65 -11.100[TW] KOG1048 Neural adherens junction protein Plakophilin and related Armadillo repeat proteins  ali follow..  352....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TLERAVSMLEADHMPPSRISAAATFIQHECFQKSEARKRVNQL-ILKLLQLLKVQNEDVQRAVCGALRNLVFEDNDNKLEVAELNGVPRLLQVLK--QTRDLETKKQITDHTVNLRSRNGWPGAVATLGGQGGRITRSGVRDQPDQHGLLWNLSSNDKLK--------------------------------------NLMITEALLTLTENIIIPFSGWPEGDYPKANGLLDFDIFYNVTGCL-----MSSAGADGRKAMRRCDGLID-----SLVHYVRGTIAD----------DDKATENCVCILHNLSYQLEAELPEKYSQNIYIQNRNIQTKSIGCFGSRSRKVKEQYQDVPMPEEKSNPKGVEWLWH------SIVIRMYLSLIAKS-VRNYTQEASLGALQNLTAGSGPMPTSVAQTVVLQHTRKMLHVGDPSVKKTAISLLRNLSRNLSL-------------------------QNEIAKETLPDLVSIIPDT-TDLLIETTASACYTLNNIIQNSYQNARDLLNTGG--------IQKIMAISAGDAYASNKASKAASVLLYSLQFKKTDFVNSRTAKAYHSLKD........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 881
66 -11.000[LDA] COG5049 5`-3` exonuclease  ali follow..  5................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KFFRWMSE------------------------------------YP-LCSQLIENDRIPEFDNLYLDMNGILHNCTHKNDDHSSPPLPEEMYIAIFNYIEHLFEKIKPKKLLYMAVDGCAPRAKMNQQRSRRFRTAKDAHDARLK--EQFDSNCITPGTTFMERVSRQLYYF-----------------------IHKKVTNDSQWQNIEVIFSGHDCEHKIMEY----RTQKAQPSYN------PNTRHCLYGLDADLIMLGSHDPHFCLLREEVTFGPASRNRSKELA-HQKFYLLHLSLLREYLECRSTFTFKYDLEKILLAFFVGNDFLPHLPGLH-INEGALALMFSIYKKVMPSAGGYINE---MARLELILLELENFEKEIFKAEVSETKNNGNSDKPSFDFLKYITESTNDIKAMTGEQKNYFLQIKKFLSSREPFIDFSANISSVDQRFLRRLCNDLHLSFSKIIKVDGTHLLRITFRDLEFNDEDEDEIEQDEIERVLQKYDNIPLLNEEQALKEKNVEKDFIQWKDDY-------------------YRSKV------------GFSYYDEEALKAMAERYVEGLQWVLFYYYRGCQS----WY-----------------YHFAPKISDVLKGLDVKIDFKMGTPFRPFEQLMAVLPARSQAL----PCFRDLMVNSESPIIDFYPKTASWEAVVIIPFIDETRLIDALASKDKFLTEEERKRNSFNAPTVF....................... 664
67 -11.000[S] COG5283 Phage-related tail protein  ali follow..  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MADIMVDSVTTGIDLNETKEAINRLKSAVKDS---TREWQINEAQAKSAGDAVSASKYRYEGLSEAMEKQKAYIANLSEGMKTINRNTDAGEKA---------------------YQKYNAQLTTAERSLASMTGQLNRAKSAYEYQQTGIEDLNKSLSANDK--------------LMQSQIDLYEKTRN---KMGAAKAEVSGLSTSYAKQTEIYRAQVT--ELKRLEAAEGTSSETLVKQKTRVNEAASSLMNYRNKLLEANLAVTKMQPFNSESLIGKGLNTV--YQTTEKATDVMAAGYQKVKSAAYQSAFGIAAIGAAAVKGAQMASELQ-------NQYKTTFNLLVTGGEQAKEAQENVNKMQEGSELSVKYGKTQKEIADGYQELIKRGYTSSQALAALPTMLQASVASGDDF--NSTAALESFGMRSNDVAGMTKNTKEAVNQMAYAADMTATDFQNMGVAMEYVGA-------SAHQSKLSLSETASAIGILSNNGLEADKAGTGLRKVIVSLQSPSKDAAEA-------------------LSGIGLSTKDFVDQNGNMKSM--LLNQHTEKLSSFQKGQIFHAAILSENVKQLGELDDKVKKSADG--------YVVNLANKNMQSTQNELKQFKAAGEAVLIMIGQRFLPVLSDAATS--------MAKAFNSKEGKQGLEEIAKWIAEIFQKLVDTVKFIGTH.......... 645
68 -11.000[U] KOG1078 Vesicle coat complex COPI, gamma subunit  ali follow..  10  1..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAQPLVKKDDDHDDELEYSPFMGIEKGAVLQEARVFNDPQVDPRRCSQVILLYLLNQGESFTKVEATEVFFSVTKLFQSKDTGLRRMVYLIIKELSPSSD----EVII-----VTSSLMKDMNSRANAIRVLCRIIDGTLLTQIERYLKQAIPVVLLKTNPEIVKRWSNEV----QEGIQSRSALVQFHLLHQIRQNDRLAVSKLVGSLTRGSVRSPLAQCL---IQRPFYEFLESCLRHKAEMVILEAARAITELDGVTSR--------------------ELTPAITVLQLFLSSPRPVLRFAAVRTLNKVAMTHPMAVTNCNIDMESLISD--QNRSIATLAITT---LLKTGNESSVERLMKQ----ITNFMSDIADEFKIVVVDAIRSLCVKFPLKYRSLMTFLSNI--------------REEGGFEYKRAIVDSIVTIIRDIPDAKESGLLHLCEFIEDCEFTYLSTFLGIEGP-NTSDPSKYIRYIYNRVHLENATVRAAAVSTLAKFGFMVESLKPR---------------------------ITVLLKRCIYDSDDEVRDR-ATLYLSEPS........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 524
69 -11.000[S] COG3523 Uncharacterized protein conserved in bacteria  ali follow..  1...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MQKFLSLLFS-----RALAVVGVLVLALL-------FVGPLVS------LRPLASVGSRVVTIALLL------LVLWLVNWSMSIIGISVLCLAIGFVTPLLALGDVHPFAPLWVRLTLIGFI------------------------------------ALYGLYRLWRALRMDEQLLRRF-----LHPRGEEVPVAGEIKADLRTVNHIVTQAIRQLRQLRVDMPGWRKIFEGKRFLYELPWFM-VVGSP----DGKTTALLNTGLQFP-FTNEAVGEWQGFLGLLRKHRPGAPLNGVILTLVADLTAQSPAERLAACAALRARLAELRETLGIRFPVYLVVTKMDLLPGFSEYFRTLTSHLACAQELARLTLRLDEEYDLKSRQRLYTFPREFAALGEPLLEAIESKFDATQLNNTLRGVFTSAAQAQADAVADQLSIWQRFVRAIKTARGESSASLPHALPDGNRSY--------FLHDLLTQFIFREAHLVEPNLQWAHLLVLVLAFLLWQGMQTSQQTNGDYLNEISARATRLDGDVKAYVPALLDSARELSAWPELDPDAPLYSVPPVTDSVASLYNRLLDQLLLPPLVKRMEYVLADAIARQDSKAAYDALRIYLL--LNLDKDHEDKYNAAEIQSWVINDLGNSDSVAGFGGRAAVLTHIEALFDG------------------------SRVVHSPYEKDEALIRQARAFLDGHTST---------RIYARALAAMESEAPQEFTLVRAVGADAGTVFVRSNGAPLDRGVPGIFTRLFDKRLPEFVAAATANDGW------------------------------MGRESTPKKLTDSLRSQIPGQEQSVAR-EVRRLYLARRWQDFLDSIHSINSAGEE--------GSSGLAYDLQVLRTLASPDSPLMRLGKAVVEQT---------------TLVPPPDPQARQKQLAQRASGNAGKVVQTAKLFQDIHPEERLEKTLVDDRFAALREVIAGRTDGGQSGGGTMQIASLLTMLNEYYTQLTIADSALAAGTLPARITAADKLQLEAAKLPAPLKNILLDLTKQGTRKINAGTGDV---LNTQMEAMMGDDCRDAIDGRYDSPQEVSAEDFNRIFALDAFWSKQLAPLADTASDPWRYKPTEGNLQGPDLTPFQQAKQIRSVFFNSEGGKKFSWSMQISVVDMDPAIMELVIDIDGQVLRYAHGPDRPLK------------VTW-----------PRNGSMAEITASPRIRQDTSTLLTGGPWALFHLLDAGMVQETAVRGRQLRRVVLEITAGRDFNPVSRELLQNFSCPARAL............ 1289
70 -11.000[T] KOG1130 Predicted G-alpha GTPase interaction protein, contains GoLoco domain  ali follow..  10  6.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SFHVRYRMEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYA--KALEYHHHDLTLARTINTLKVLGNFDEAIVCCQRHLDIS-RELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDV-EEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLL------GNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYFLGEFETASEYYKKTLL-LARQLKDRLGNTYTLLQDYEKAIDYHLKHLAILNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKH---------LEISREVGDKSGELTARLNLSDLLGLSYSTNNSIMSENTEIDSSLNGVLPKLGRRHSMENMELMKL--TPEKVQNWNSEILAKQKPLIAGKKYKTNSSTKVLQDASNSIDHRIPNSQRGDEGFFDLLSRFQSNRMDDQRCCLQEKNC--TTSSTPPKMMLKTSSVPVVSPNTDEFLDLLASSQSRRLDDQRASFSNLPG-DFFDILVKCQGRLDDQRCAPPPATTK------PTVPDEDFFSLILRSQGK---RMDEQRVLLQRDQNRDT----DFGLKDFL-QNNALLEFKNSG.......... 671
71 -11.000[S] COG3513 Uncharacterized protein conserved in bacteria  ali follow..  137...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HLREELVNSSEKADLRLVYLALAHIIKYRGNFLIEGALDTQNTSVDGIYKQFIQTYNQVFASGIEDGSLKKLEDNKDVAKILVEKVTRKEKLERILKLYPGEKSAGMFAQFISLIVGSKGNFQKPFDLIEKSDIECAKDSYEEDLESLLALIGDEYAELFVAAKNAYSAVV----------------LSSIITVAETETNAKLSASMIERFDT-HEEDLGELKAFIKLHLPKHYEEIFSNTEKHGYAGYIDGKTKQADFYKYMKMTLENIEGADYFIAKIEKENFLRKQRTLEELEAILHQQAKY-----------PFLKENYDKIKSLVTFRIP------------VGPLANGQSEFAWLTRKADGEIRPWNIEEKVDFGKSAVDFIEKMTNKTYLPKENVLPKHSLCYVYNELVRYIN-KTSYFSGQEKEQIFNDLFKQKRKVKKKDLELFLRNMSHVESPTIEGLEDSFNSSYSTYHD-----------------LLKVGIKQEILDNPVNTEMLENIVKILT---VFEDKRMIKEQLQQFSDVLDGVVLKKLERRHYTGWGRLSAKLLMGIRDKQSH-ILDYLMNDDGLNRNLMQLINDSNLSFKSIIEKEQVTTADKDIQSIVADLAGSPAIK-KGILQSLKIVDELVSVMGYPPQTI--VVEMARENQTTGKGKNNSRPRYKSLEKAIKEFGSQILKEHPTDNQELRNNRLYLYYLQNGKDMYTGQDLDIHNLSNYD-----IDHIVPQSFITDNSIDNLVLTSS------AGNREKGDDVPPLEIVRKRKVFWEKLYQGNLMSK--RKFDYLTKAERGGLTEADKARFIH--------RQLVETRQITKNVANILHQRFNYEKDDHGNTMKQVR----IVTLKSALVSQFRKQFQLYK--------VRDVNDYHHAHDAYLNGVVANTLLKVYPQLEPEFVYGDYHQFTNIMLFFAQKDRIIDENGEILWDKKYLDTVKKVMSYRQMNIVKKTEIQKGEFSKATIKPKGNSSKLILDSPNMAYAVVIEYAKG--KNKLVFEKKIIRVTIMERKAFEKDEKAFLEEQGYRQPKVLAKLPKYTLYECEEGRRRMLASANEAQKGNQQVLPNHLVTLLHHAANCEVSDGKLDYIESNREMFAELLAHVSEFAKRYTLAEANLFEQNKEGDIKAIAQSFVDLMAFNAMGAPASFKFFETTIERKRYNNLKELLNSTIIYQSITLYESRKRLDD........ 1334
72 -10.900[L] COG1643 HrpA-like helicases  ali follow..  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MTEQSTLTLQVLQQRLDALMLRDKQRFARRLHGVKKVKNPDA-AIFQTMAKEIEQAAAQVALREAARPSITYPQNLPVSQKKQDILEAIRDHQVVI---VAGETGSGKTTQLPKICMELGRGIK--------------GLIGHTQPRRLAARTVANRIAE--RFSDHVSSNTMVKLMTDGILLAEIQ--QDRLLMQYDTLIIDE----------AHERSLNIDFLLGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIESGRTYRDQLQAIFDAVDELGRESPGD-IFMSGEREIRDTADALNK-VLP--LYARLSNSEQNRVFQSHSGRRIVLATNVAETS---------LTVPGIKYVID-ISRYSYRTKVQRLP-------------------------------IEPISQASANQRKGRCGRVSEGILYSEDDFLSRPELRTNLASVILQMTALFPFVEAPDKQDGVRLLEELGAITAD------EQQTAYKLTPLGRQLSQLPVDPRLARMVLEA-QKHGCVREAMIITSALSIQDPRERPVDKQQASDEKHRVNLWNYLGEQQKALSSNQFRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAE-YREIHVALLT--LLSHIGMKDA-------------------------DKQEYTGARNARFSIFPGSGLFKK-WTMVAELVETSRLWGRIAARI--VEPVAQHLIKRSYSEPHWER---AQGAVMATEKVTVYGLPIVAARKVNYSQIDPALCRELFIRHALVEGDWQTRHAFFRENL--KLRAEVEELEHKSRRR--TLFEFYDQRISHDVISARHFDSWWKKISRETPDLLNFEKSMLEGAEKISKLDYPNFWHQ-LSYQFEPGADADGVTVHIPLPLLNQVDESGFE-RRELVIALIKSLPKPVRRNFVPAFLGRVTPLELPLLDALERELRRMTDQVPEHLKITFRVVNDKNKKLQEGRSLAELKNALKGKVQETLSAVADDGIEQ..................... 1014
73 -10.900[S] COG5369 Uncharacterized conserved protein  ali follow..  11.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SFFKENPKIFKDEHELLRYIVPFKNVIGRPDRKEYAIRNGAPKLLLNLFSLESMNEKYQVFVVLNSLMSEDQDPFVQFLRHEDLLSVMQMISKRDSTPYGMLNITLKVFNTMLSYVTQLHSDSIINQMFDLYTLPLKEQPSLDVLRISNLSSKHRLILYNSKVGDSPRFCSALFQITNRATQLLGTLNAYLKQHVKSYKQREKTRLESNGHVSPRDMDLDEIENVFEGNKDKVALEYITQLFCLVRQFDPCIRLLSISCLVTLYKAGILSKNQTKEIQMIVTPILIRLF-----FESREAKQIAPRILAIIINENEIMQKTAVNAGFIDAAKYLLEYATKEEENEINFLSDELQSSAACECLLSLSRSVYILRTGLADVSEPLIKLLSD--PDTRVKSTATSAICNLVLKFSPLREKFLTTNFIDTLISNISTKDSSLRKKTVWVLRHVVFGDDETIQLEPLK-----------------------------ASKLVELCNDEDLGVQEQMLQVLRNFTCQKEESVDFLLKMVPMELLAKILLEKL-------ESKNPILIEPSIYILVHIAASDGELRDSILRQTKLLLLVKEIMLQEAQRLKPEQMSTNVYEEDTYEPNSEILLAGIWLCINILQNLGFGECLQMLQNHSSP------DVRERVKDALMYINVTD................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 729
74 -10.900[R] KOG1293 Proteins containing armadillo/beta-catenin-like repeat  ali follow..  11.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SFFKENPKIFKDEHELLRYIVPFKNVIGRPDRKEYAIRNGAPKLLLNLFSLESMNEKYQVFVVLNSLMSEDQDPFVQFLRHEDLLSVMQMISKRDSTPYGMLNITLKVFNTMLSYVTQLHSDSIINQMFDLYTLPLKEQPSLDVLRISNLSSKHRLILYNSKVGDSPRFCSALFQITNRATQLLGTLNAYLKQHVKSYKQREKTRLESNGHVSPRDMDLDEIENVFEGNKDKVALEYITQLFCLVRQFDPCIRLLSISCLVTLYKAGILSKNQTKEIQMIVTPILIRLF-----FESREAKQIAPRILAIIINENEIMQKTAVNAGFIDAAKYLLEYATKEEENEINFLSDELQSSAACECLLSLSRSVYILRTGLADVSEPLIKLLSD--PDTRVKSTATSAICNLVLKFSPLREKFLTTNFIDTLISNISTKDSSLRKKTVWVLRHVVFGDDETIQLEPLK-----------------------------ASKLVELCNDEDLGVQEQMLQVLRNFTCQKEESVDFLLKMVPMELLAKILLEKL-------ESKNPILIEPSIYILVHIAASDGELRDSILRQTKLLLLVKEIMLQEAQRLKPEQMSTNVYEEDTYEPNSEILLAGIWLCINILQNLGFGECLQMLQNHSSP------DVRERVKDALMYINVTD................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 729
75 -10.900[S] KOG4507 Uncharacterized conserved protein, contains TPR repeats  ali follow..  1..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAAAVGVRG-----RYELPPCSGPGWL------------LSLSALLSVAARGAFATTH-------------------------------------W-VVTEDGK--IQQQVDSPMNLKH----PHDLVILMRQEATVNYLKELEKQLVAQKIHIEENDLYDGTYITLESKDISPEDYI-PDCTKILELPCSIHAFQHLRGVQERVLSAPLLPKEDPIFTYLSKRLGRSIDDIGHLIHEGLQKNTSSWVLYNMASFYWRIKNEPYQVVECAMRALHFSSRHNKDIALVNLANVLHRAHFSADAAVVVHAALDDSDFF------------TSYYTLGN---------------------IYAMLGEYNHSVLCYDHALQARPGFEQAIKRKVLCQQKLEQ-------LEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRLVNQVRYHRGDIFENVDYVQFGEDSSTSSMMSVNFDVQSNQSDINDSVKYLVKELEVRMDLKAKMPDDHARKILLSRINNYTIPEEEPNAPIWLILNEAGRAVGNSTFAIACLQRALNLAPLQPLVNLANLLIHYGLHLDATKLLLQALA--------------INSSEPLTFLSLGNAYLALKNI---------SGALEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGNCHEKTLDNSRDKQKYFDNSQSLDAAEEEPSERGTEEDPVFSVENSGRDSDALRLESTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDGV-SCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKTPGKKVETGQIENGYQANLEITGPKVAS-KT 952

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lesley SA, Kuhn P, Godzik A., Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J, Taylor SS, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11664-9. Epub 2002 Aug 22.