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Query: [K] COG5111 DNA-directed RNA polymerase III, subunit C34, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MADQLRTLPKNAKVIYEHCLKQIPNSLSQQDLVEAIGASISVNDLSSALNILLSRRLLDPLRQGNVLVYRAVRLDEAKTVSTMEGDEQIVYSFIKNSGNEGIWRKTLTLRTNLHVSVVDRCLKSLESKNLVKSIKSVKNPTRKIYMLYDLVPSTELTGGPWFTDQELDVEFIENLKKVIYRYVHSKSFPPKKAAMGPDLVWGPEYNGYPTALQIHNWLRSTNITKVDLSLANVISLVDVLIYDGKVEKRSDGASYRAIRVNNENIDAFTESPCGNCPVSDICDANSRVNPITCEYLDKWLNLast
1 -111.000[K] COG5111 DNA-directed RNA polymerase III, subunit C34  ali  100  1MADQLRTLPKNAKVIYEHCLKQIPNSLSQQDLVEAIGASISVNDLSSALNILLSRRLLDPLRQGNVLVYRAVRLDEAKTVSTMEGDEQIVYSFIKNSGNEGIWRKTLTLRTNLHVSVVDRCLKSLESKNLVKSIKSVKNPTRKIYMLYDLVPSTELTGGPWFTDQELDVEFIENLKKVIYRYVHSKSFPPKKAAMGPDLVWGPEYNGYPTALQIHNWLRSTNITKVDLSLANVISLVDVLIYDGKVEKRSDGASYRAIRVNNENIDAFTESPCGNCPVSDICDANSRVNPITCEYLDKWLN 301
2 -95.200[K] KOG3233 RNA polymerase III, subunit C34  ali follow..  28  8VQPPDADPVEIENRIIELCHQF-PHGITDQVIQNEM-PHIEAQQRAVAINRLLSMGQLDLLRSNTGLLYRIKDSQNAGKMKGSDNQEKLVYQIIEDAGNKGIWSRDIRYKSNLPLTEINKILKNLESKKLIKAVKSVAASKKKVYMLYNLQPDRSVTGGAWYSDQDFESEFVEVLNQQCFKFLQSKAETARES---KQNPMIQRNSSFASSHEVWKYICELGISKVELSMEDIETILNTLIYDGKVEMTIIAAKLYRAVNPIIPPTGLVRAPCGLCPVFDDCHEGGEISPSNCIYMTEWLE 315
3 -13.600[S] COG3398 Uncharacterized protein conserved in archaea  ali follow..  15  109........NSNRARIYEYIKTRP--GAYLSEIIEKA--GIDRGAARYHIKILKAHHKIEAYRESGKTRYFQNNSTYGEEEKKVNATNQRIISEIQN--GKCNTNLALAREIGVSRATISWYVKNLKETGLIDETRS---GRSIIYSINP........................................................................................................................................................ 245
4 -12.800[S] KOG4608 Uncharacterized conserved protein  ali follow..  10  1MSVDDDEILKVFDIVMKKIRHLENSDLHFERIHVNLAKKERFFDDVQSDEKLAEICDFLSQNCREISNSPRATLDEWIQTGGKFEIQRAVCHVIKATRQVGITLGELCGKVKIAKEQIAEILADLSGAAQIDEKRWVMPEYEACWMV---IGDKKWCPRPWIAEGCISLPVVRWMAESALVLIVSKL---------------------IQLKDVITTYEFA------VQPIAIREIVRKEKSAKKSPKI.................................................... 238
5 -11.500[S] COG2512 Uncharacterized membrane-associated protein/domain  ali follow..  14  236........................................................................IETAALNRIPLSPELCEVLDIIRGHKGR-ITQKDLRSKLDYSEVKVSLMLSELEKRGLIRKLR--NGRENILVLVDEEH...................................................................................................................................................... 311
6 -9.520[K] COG3355 Predicted transcriptional regulator  ali follow..  14  24.................................................................................GLSKSDVEVLHILLQNG--KMTTDDLSQKLNVTKASISKALNNLLDKGLIQREKAPAEKEERKGRPNYWVEKERLYRKLEADLEKLAGTVKEALQKHTALEI...................................................................................................................... 125
7 -9.440[K] COG5625 Predicted transcription regulator containing HTH domain  ali follow..  10  18.................................................................................GLKKNEIRIYRLLVEKRRG-MRIREIQRELGISERSVRTHVLNLYRRGLLKRELVQSGWLGYIYTPVSPLEILQKIKEHLMKSIEELERDLKNQTRS........................................................................................................................... 113
8 -9.420[K] COG2345 Predicted transcriptional regulator  ali follow..  10  4........................................................................VVKGNDAHTGDGDTRRKILLILLERA--PVIASDIAEQLQLSTVGVRRHLDNLVEENLAEAANPRQNPYEP--------KMRGRPAKTYRLTDKGRSIFGHEYDSLAAAALATLREVGGDDAVRQFARKRIETIVEGITPAD------VTDQSIEDTAKSLVEAFSRHGYAATVDATRNG----------------LQLCQHHCPISTVATE----FPELCEAEHQAVS 196
9 -9.080[K] COG1846 Transcriptional regulators  ali follow..  16  39.................................................................................ALTPSEIHTIDAIGT--DEGLLMKELAERLGVTKGAVSQLVDRLEAKALVRRTAH--PKVSRGIQVVLTDKGREAYRAHADMHAAFYEELQQSFTKEEIAIFEQ.................................................................................................................... 138
10 -9.000[K] COG1695 Predicted transcriptional regulators  ali follow..  9  1..................................................................................MDRYAIKALVLLSKKPRTL--SKEISTGVQVSHGTLMPMIRKLLQERYID---FETRGREKVYHLTE-------RGSRFVESLG---KIEEDVKQNLISRTMGDAFFYLNLLSKNDTSEAIKSAIQILLPAIIAQVEYAFRMLMEGHREEVEGVARDL............................................................. 146
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. Discovering new genes with advanced homology detection. Trends Biotechnol. 2002 Aug;20(8):315-6.