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Query: [KB] COG5137 Histone chaperone involved in gene silencing, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSIVNILSVNVLNNPAKFSDPYKFEITFECLEPLKSDLEWKLTYVGSATSQSYDQILDTLLVGPIPIGINKFVFEADPPNIDLLPQLSDVLGVTVILLSCAYEDNEFVRVGYYVNNEMEGLNLQEMDDAEIKKVKVDISKVWRSILAEKPRVTRFNIQWDNPDFDDAPPVQPDADEEEEEEEADEMEEEFDEEGEGDEEEEEEDDGDGDGEGDGDGEGENDGKGSEEEEEEEIDIEEEEEESALANASAAEEKPEEKPETSQLast
1 -70.500[KB] COG5137 Histone chaperone involved in gene silencing  ali  100  1MSIVNILSVNVLNNPAKFSDPYKFEITFECLEPLKSDLEWKLTYVGSATSQSYDQILDTLLVGPIPIGINKFVFEADPPNIDLLPQLSDVLGVTVILLSCAYEDNEFVRVGYYVNNEMEGLNLQEMDDAEIKKVKVDISKVWRSILAEKPRVTRFNIQWDNPDFDDAPPVQPDADEEEEEEEADEMEEEFDEEGEGDEEEEEEDDGDGDGEGDGDGEGENDGKGSEEEEEEEIDIEEEEEESALANASAAEEKPEEKPETSQ 262
2 -51.600[KB] KOG3265 Histone chaperone involved in gene silencing  ali follow..  32  2ASRVNIVQVQILDNPAMFVDKFKMEITFEVFEHLPHDLEWELVYVGSGTSRDFDQVLDSALVGPIPEGRHKFVFDAEHPDISKIPV-EDIVGVSVLLLRCKYNDQEFINMGWFVANEYTDEELKENPPAKPRTVFVESNKALHLTSNEDDCSGNYKTCINNSSDSFVENLSRKIETEDLRVTTFPIRWTDEDPVAEPVDEEANKVFDEDDLMPLHDDGQDDDEEEEDDDETGPNTEEVDLNESFNERMANAHDGTEQKNGEE 292
3 -16.100[K] KOG2478 Putative RNA polymerase II regulator  ali follow..  12  385..................................................................................................................ETEEKEAGGSDEEQEKGSSSEKEGSEDEHSGSESEREEGDRDEASDKSGSGEDESSEDEARAARDKEEIFGSDADSEDDADSDDEDRGQAQGGSDNDSDSGSNGGGQRSRSHSRSASPFPSGSEHSAQEDGSEAAASDSSEADSDSD. 531
4 -13.200[R] KOG4334 Uncharacterized conserved protein, contains double-stranded RNA-binding motif and WW domain  ali follow..  8  1.................................................................................................................MEQESGGKKSNEQLLSEREAIMRQLAMLGSGPEDLDVDDEEEDEEEEVEKMEEGVEETMENASVVKETTPVKDENIVEDSNSSEELFPYLDSPPEDKIQEISANDTEIDQIDSPIRFEGVKNPAQKMDVDGEEGTSTDARPVSGSSGSS 149
5 -12.000[K] KOG2473 RNA polymerase III transcription factor (TF)IIIC subunit  ali follow..  11  403.......................................................................................................................PEPGFEDVFKSIQEEFERSEKTRIQKDALQPSQRNHQETTKDMKKCKNTNKEKDDDVNADEDSEDLDDEYEEAANDDDISISSHGYGDMENNSRTYLQGLFNRFPSSASALYGSANDDNDSDGEYPIYEQESNALDDDEEDDE 545
6 -11.700[J] COG5593 Nucleic-acid-binding protein possibly involved in ribosomal biogenesis  ali follow..  13  697...............................................................................................................FFNDKYIKGKQARKTKVDRDEEGEIDEDEVWKALVDSKPQLEMDEEESDFDSEEMDKAMTDMGSDSEQSADENDNESMASEEKPMFSDEENLSEIAHSEDEFDDTVDFFEDENDLLPFNETDDEEEIQTVDHSETHSHKKKKRKAIKDLP. 846
7 -11.200[R] KOG2295 C2H2 Zn-finger protein  ali follow..  11  337..................................................................................................................ENSAPKKELAEDSKDSDSKPEDKQLNKKKTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGPQSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEK 484
8 -11.100[S] COG5604 Uncharacterized conserved protein  ali follow..  14  27..................................................................................................................DTDKGIRQKHSKKEGKDETLKRDVEKFIQNVNSEDTPSEDDSMSMDAFLEGGFEELDSANSNDAGSSRKRKNLPNENTQDSTSESSEEEEDGLESYQKQLEGLKEKDPEFYKFLEQNDQDLLEFNAAETDAMAKEIDENERLKSSSGK 174
9 -11.100[J] KOG2256 Predicted protein involved in nuclear export of pre-ribosomes  ali follow..  14  27..................................................................................................................DTDKGIRQKHSKKEGKDETLKRDVEKFIQNVNSEDTPSEDDSMSMDAFLEGGFEELDSANSNDAGSSRKRKNLPNENTQDSTSESSEEEEDGLESYQKQLEGLKEKDPEFYKFLEQNDQDLLEFNAAETDAMAKEIDENERLKSSSGK 174
10 -10.900[S] COG5291 Predicted membrane protein  ali follow..  12  123.................................LGTSFSATITYIWTKRNP--RAIVQIFGFISFPAFYLPFILPGFMLLSRRSISIDDVLGIVVGHLFHYFKGRDILSTPCWVKKLFNEHPSSCCKARKGITIREGRERHERNMGYSNASTTSGDSMASLTDMADTKSSTENSAVTEESQCCAESFKDSSVVSSQKSMAVSTVVGSSTEAKNNYLDFTEALCDKEVVAEQNPESQSNEEWDEKWGDSDNESECS....... 348
11 -10.300[S] COG4392 Predicted membrane protein  ali follow..  13  1MVWAVIFGMGAIVFLNRY-----LFLEPRLPIRLGSNLRQFLGFAVPG-------MLTAICGPIVFMPEGRIDLGYDNP---------YLVSGAVTVALVLYTRNTLASM........................................................................................................................................................ 89
12 -10.200[S] KOG4610 Uncharacterized conserved protein  ali follow..  8  368..................................................................................................................KDYAEQEAVYSKKKKDKKDKKKRKRKDTGYSTASSQNLYSTKASGTDKDTRRKDKKGKKSKRTCSSSPSDCDLAKKQKRKNADKNDKKKSRKIEAVVEESSSSSSSSSDSSNSTLPSYEVIDEKKARRRKHRGSSSDTSSGDSSSSSS 515
13 -9.880[KU] KOG2773 Apoptosis antagonizing transcription factor/protein transport protein  ali follow..  9  26..................................................................................................................SDSAEDSDFDVATGPRLVDFEEEEYDLPDARSTDFRKRNVKLLSEQSDRYKGKISSRKELDDDEDKDDEQEVSYEESDEDDENLTNFKQKLNAGGAEDSEEETAAGHSESGEESEEIESNLTDFKKKFEAGDFKYDDDEEEDDDSEEE 173
14 -9.770[J] KOG0650 WD40 repeat nucleolar protein Bop1, involved in ribosome biogenesis  ali follow..  10  10..................................................................................................................RGKDSEPTNEVVASSEASENEEEEEDLLQAVKDPGEDSTDDEGIDQEYHSDSSEELQFESDEEGNYLGRKQSSSAEEDEESSDEEDNEEEESTDGEEVEDEEKDSKSKQTDDKPSGSGAASKKALTAELPKRDSSKPEYQDSDTSDEE 157
15 -9.690[R] KOG4264 Nucleo-cytoplasmic protein MLN51  ali follow..  12  31..................................................................................................................RGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSAEESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKN 178
16 -9.690[S] KOG4852 Uncharacterized conserved protein  ali follow..  17  162............................................................................................................................................................................DEDDSDGPPADDEDDSNDEDNWRNDYPDEESYDEDSDNGDPYGISEPDHWHAGEEAYSDESFHRRLQNMDLNDERYEAFYEGDETDEDAD 251
17 -9.460[R] KOG1400 Predicted ATP-dependent protease PIL, contains LON domain  ali follow..  11  1.................................................................................................................................................MDEEENSEINSVQARDEDVQLEDQQSQGLQDRQVDVIEQAWNNAMPDEPSPPAEDAFQDPLATDGEGGDALEAMVENVLQDDTASEGSHPSSDMSLESPGSEDDSDLESLPHWMIPQ 117
18 -9.440[K] KOG2393 Transcription initiation factor IIF, large subunit (RAP74)  ali follow..  12  230..................................................................................................................DEEEGNVSDRGDEDEEEEASRKSRLGLNRKSNDDDDEEGPRGGDLDMDDDDIEKGDDWEHEEIFTDDDEAVGNDPEEREDLLAPEIPAPPEIKQDEDDEENEEEEGGLSKSGKELKKLLGKANGLDESDEDDDDDSDDEEETNYGTVT 377
19 -9.090[A] KOG2242 Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain  ali follow..  9  2...............................................................................DVRRLKVNEDTRGLKTELAE---------RLQAALEAEEPDDERELDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPGGYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFE 185
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 1 9   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;