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Query: [T] COG5212 Low-affinity cAMP phosphodiesterase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MHAALEIKEAEFQTDQVVGLVENSFTLYSLGQNGGPLESCCSSHLISDGAFQEIISLDGGSHLSALVELIQSKHLSVDSWSSITKYDNYTVENESYAKAWHLSEQRIKTFLITHCHLDHIYGAVINSAMFGPQNPRTIVGLNYVIDTLKKHVFNNLLWPSLDKAGFINFQVVEPSMYTSLTTTLSILPFPVNHGSSFGQELKSSAFLFRNNLSDRYFLAFGDVEPDMVASEPLNIHIWRACSSLIAQRKLSHILIECSTPDIPDTLLFGHFCPRHLVNELCILQSLVQSYGVIMPTLTCLLTHLKSHPLQSANPADVILEQLESLSSKSSLSVTFKILQRGQFYKFLast
1 -102.000[T] COG5212 Low-affinity cAMP phosphodiesterase  ali  100  1MHAALEIKEAEFQTDQVVGLVENSFTLYSLGQNGGPLESCCSSHLISDGAFQEIISLDGGSHLSALVELIQSKHLSVDSWSSITKYDNYTVENESYAKAWHLSEQRIKTFLITHCHLDHIYGAVINSAMFGPQNPRTIVGLNYVIDTLKKHVFNNLLWPSLDKAGFINFQVVEPSMYTSLTTTLSILPFPVNHGSSFGQELKSSAFLFRNNLSDRYFLAFGDVEPDMVASEPLNIHIWRACSSLIAQRKLSHILIECSTPDIPDTLLFGHFCPRHLVNELCILQSLVQSYGVIMPTLTCLLTHLKSHPLQSANPADVILEQLESLSSKSSLSVTFKILQRGQFYKF 346
2 -55.700[R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I  ali follow..  14  1...MLLGCAMAFDSDTRSRESNRNFRVKIWGARGTLYGGNTICIEVRCG--DHVLLFDAGSGLHPAGLALRAE------------------------------GITDVNLFFSHCHYDHIVGFPYFKPFYNSSNDVAIWSGSMTTREMLKDFMSPPWFPVPLEIAKIATRDFKAGDVLDVHPGLSIRTGMLNHPGN--------AIGYRLDWEGKSLAIITDTEHEPSSIDETVLDL---------IRDVDLFLYDAMFTDEELYRGYGHSSWQQAIR-----------LAKLADAKNVGFIHHAPSRSDE--ELDDIEKQAKAEFN------GAFAAMDGQVIEI 292
3 -37.100[R] COG2248 Predicted hydrolase (metallo-beta-lactamase superfamily)  ali follow..  10  23.PQVPGSNPGRGTTRILTTFKAINMKVIPLA--SESLGVRSLALFLKIG--KVGILIDPGVALGPKRYALPPAQAEMKALS-------------LAREKIQEYAKKAQIVTISHYHYDHHTPFFEGIYESSSVEAREIYAGKLLLIKHPTENINNSQKKRAHEKEIAKDIKFADSQSFDF-GSFTIEFSPVPHGRE--GSKLGYVLMVLVDDGKKSVLHASDTQLIN-----------DKAVEWIIEKNPDILIAGGPPTYLAHVGNVKEIGMKNINRIISETN------------AKIVLDHHIIRDKGYERFFSELDERPLTFAEFLGKESAPLEAYRRELHK. 331
4 -35.700[R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III  ali follow..  10  1........................MDIQFLGTGAGQPSRNVSSLALKLDEINEVWLFDCGEG------------------------------TQNRILETTIRPRKVSKIFITHLHGDHIFGLPGFLSSRAEQTDLEIYGPQGIKSFVLTSL-----VSGSRLPYRIHFHEFDQDSLGKITDKFTVYAEELDHT------IFCVGYRVMQKRPGKIITILGDTRKTGASVR--------------LAVNADVLVHESTYGKGDEKIAHGHSTNMQAAQ-----------VAVEAGAKRLLLNHISARFLS--KDISKLKKDAATIFE------NVHVVKDLEEVEI 309
5 -25.500[R] KOG2121 Predicted metal-dependent hydrolase (beta-lactamase superfamily)  ali follow..  12  462.EKLWLSECNTVLPNCLEKIRRDDMEIVILGTGSSQPSRNVSAIFIDLF-SRGSLLLDCGEGLGQLKRRYGLD-------------------------GADEAVRKLRCIWISHIHADHHTGLARILAL-VTHEPVIVVGPRPLKRFLDAYFTQGSPMQSVFKRSDISMDNSSVLLCLKNLKKVDLISFPVVH-------PQAYGVVIKAAILGWKMVYSGDSRPCPETVE--------------ASRDATILIHEATFEDIEEALAKNHSTTKEAID-----------VGSAANVYRIVLTHFSQRYPKIPVIDESHMHNT--------------IAFDLMSINM 797
6 -22.600[J] COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing  ali follow..  12  2........................................LSVISSEIGVISK-KLIDLGALRQRNSRGNFKPHVSIRFRNNAGELRTFSIDTTRSPGKQ----PQPDAYLITHAHSDHHGKSAMLSP--------RAVCTDKTATALEIRHDR-----------KYVGSMCRLGDEIEI-EGVRVKTYPTAHTAG------AAAFYWEND-VGTRILVTGDVKNASKL------------------PPCDVLITEANYGDPEDPSCHFADDLESMKCALFE-SGPVAFGAYEFGKAQRAVELMRGFGYEGAIRMEARTRALTRSMLEDAGELAGIDSRGEDEVFV 258
7 -20.800[R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily  ali follow..  16  2......................SNIKITPLG---GVREFGKNMYLVEV--EEQIFVLDAG---------LKYAEMDQLGVDFVIPDITYLLE----------NADRVAGIFLTHGHADSIGALPYIVSEL----KVPVFGSELTIELAKINVKNYAD-----SRKFNDFHVVTEDTEIDF-GKAVISFFSTTHTIPE-------SLGIVISTNDGNIVYTGDFRFDPAVAKGYRTNMRRLAE--IGNSGVLALLSSSPNALSTMQSASEHEIYEKIYDYIDDNEGRVIIACNAGNLGRI............................................... 235
8 -20.800[R] COG1782 Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain  ali follow..  13  173...................IDEKWVRVTFLGGSREVGR---SCYLLQTPESR--ILIDCGVNVSNLSSTPYLY------------------------VPEVQPLDALDAVVITHAHLDHCGLVPLLYKFGYRG---PIYLTPPTRDLVAGREGTNPPYSS-IREALKHTITLDYGVVTDISPDVRLTFYNAGH-------LGSAIAHFHIGEGHYNIAFTGDFKFEKTRLFD---------RAATNFPRLEALVMEATYGGPNDFQPSRKEAEERLIEVINRTLDRGG---------KVLI----PTFAVGR--SQEVMIVLEEAMREKRLR-ETYVYLDGMIYEA 447
9 -20.200[A] KOG1136 Predicted cleavage and polyadenylation specificity factor (CPSF subunit)  ali follow..  16  2......................PDIKITPLGAGQDVGR---SCLLLSMGGKN--IMLDCGMHMGY--------------------NDERRFPDFSYIVPEGPITSHIDCVIISHFHLDHCGALPYMSEIVGYTGP--IYMTHPTKAIAPILLEDMR--TQMIKDCMKKVIPVTLHQSMMVDTDLEIKAYYAGH----------GAAMFWIKVGSQSVVYTGDYNMTPDRH-----------AAWIDKCRPDLLISESTYATTI------RDSKRCRERDFLKKVHECVA-----KGGKVLI----PVFALGR--AQELCILLETYWERMNLKYPIYFAL....... 269
10 -18.300[A] KOG1137 mRNA cleavage and polyadenylation factor II complex, BRR5 (CPSF subunit)  ali follow..  12  1...MASSSTSLKRREQPISRDGDQLIVTPLGAGSEVGR---SCVYMSFRGKN--ILFDCGIHPAY--------------------------GMAALPYFDEIDPSSIDVLLITHFHIDHAASLPYFLEKTTFNGR--VFMTHATKAKVSKVSVEDMLFDE-INKSMDKIEVIDFHQTVEV-NGIKFWCYTAGH----------GAAMFMVDIAGVRILYTGDYSREEDRH-----------AAELPQFSPDICIIESTSGVQL------HQSRHIREKRFTDVIHSTVA-----QGGRVLI----PAFALGR--AQELLLILDEYWANHPDLHNIPIYYAS..... 282
11 -17.700[R] KOG3798 Predicted Zn-dependent hydrolase (beta-lactamase superfamily)  ali follow..  11  61.KKVLDSTLPVHNITADDFHSESGLFATWLG----------ATVLVDLEGVK--FVTDP--------------------ADRASFTSFAGPKRYRPPPMKLEDLPDLDFAVVSHDHYDHL-DADAVKRITNLNPQIKWFVPLGLKKWMKNQ------IGADGSNTVTELNWGESSEFVKNGKTITIWCLPAQHSGQRGLSDHNHRLGWAVIGENRRFYFPGDTGFCDVEFKKIGEKL----------GPFDLAAIPIGAYEPRWFMKSHHINPDEAVEVHKLV-----------RARNSIGIHWGTYPMGTTEYYLEPRDKLKELMDARE-DTSFVTVDMGEIWEA 353
12 -16.900[L] KOG1361 Predicted hydrolase involved in interstrand cross-link repair  ali follow..  11  165......................................................................................................CVQGCSAYFLTHFHADHYIGLT------KAWSHGPIYCSSLTSRLLRLSL----------SVNPSSIHPLELDVEYTI-NGIKVTLIEANH---------AALIHFRLL-DGTCYLHTGDFRASKQMQT----------HPLLFNQRVHVLYLDTTYCNPRYKFPSKEDVLSYVVRITKDFLRKQPKTLIVVGSYSI---------------KECVYLAIAK-----ALGVKIFANASRRRI.. 353
13 -15.000[R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold  ali follow..  13  80.KDRNPVSPIPVYVIDWNKINSENDSLTWFG----------SAFLLNVDNKQ--LLIDPGPVVSPVSFVGRNRYEYSEDIMLHLIDE----------------MPPIDAVLITHDHYDH---LDYRSIVKLNNKVSHFFVPLGCSAHLIR------------GIPEEKITELNWWEETEY-QGLTVALTPSRHSSGRNPFNIDTTLGWVILGNKTRVYTSGDSGYGPHFKQ-------------DKYGPFDITLIEGQYDRNWPDL---HMVPEQAIQANLDV-----------GGKTMMLMHWGAFTLANHAWNEPIERALKEAKIR---EVNIIAPMIGETVLL 359
14 -14.900[S] KOG4736 Uncharacterized conserved protein  ali follow..  13  252TTTPKVNSWAKLWTSTAEPKSYVNVTVLQAGLRDGQVEAVGAITLVNDN--GYIVLIDTGASSDT--------------------------RLLHSLAKESVTLDQIDSVVITHASPGHMGNMNFF---------------AQKPILYHSMEYIGRHVTP---------TELKERPYRKLSGNVEVWKTP-GHTQH------DLSVLVHNVAGYGTMAIVGDLIPSEHLLSEKRDVMIEEWDNAIKRQNANLIV------CMADWIVPGHGQPFRVLPNYRQKAGCTRLLAQRHLLNQAFLSFFR---LHGDVLSFIISLPFHFCLQNFPLRKTVCTMYDCSRFK. 535
15 -14.800[R] COG0491 Zn-dependent hydrolases, including glyoxylases  ali follow..  11  2.......................EILGFAAGP-------KTNCYVV--RGENEVAIIDPGMH-----------------------------AHDDLVEYITTNNLSVDKIVLTHGHIDHTRDAGVVAKRF----NAPVYIHPDDAFFLEVYKGSGTKTAMLFDADNMVSPDPESLRDLVDGETITLAGEEFTLKHAPGHSPGCTLIVG------KEYCFSGDV---TDFEWSDADAMNESLRTAVLPLDDALQILP------------GHGPTTTMRAERTG................................................................ 206
16 -14.500[R] KOG0813 Glyoxylase  ali follow..  11  5...............PAVTRLTSSVIRILGCNPSAMTLQGTNTYLL--GSGSRRILIDTGD-------------------------EDVPQYIAHLGDVLQQEKASIDTILLTHWHHDHVGGV----KSIVGTKLAEKDCRVFKFGRTDAPDVCPE------IPTDIKLHPLAHNQEFTTEGANVRVVHTPGHTTDHVVLAM-----------NEGTLFSGDC-----ILGEGTAVFEDLFEYMKSLEKILDIKPQRIFP--------GH---NVIEEPIGKIEYYINHRNQREQQILQFFVQRPNENLQAMDVVKVVYKETPEAAAYNVNHHLSKLEKEGK.... 272
17 -14.400[A] KOG1135 mRNA cleavage and polyadenylation factor II complex, subunit CFT2 (CPSF subunit)  ali follow..  1....................MTSIIKLKVFS---GAKDEGPLCYLLQ---DGDYILLDCGWDER----------------------------GLQYFEELKPFIPKISAVLISHPDPLHLGGLPYLVSKC--GLTAPVYATVPVYKMGQMFIYDEHYTLDDVDTAFEKVEQVKYNQTVVLKGGVHFTALPAGHM--------GGSIWRICRVTGEDIVYCVDFNHKKER----------NGCSFDNFNRPHLLITGAHHISLPQMRRKDRDE-TKILRTVRQKGDCMIVIDTAGRVLELAHL............................................ 248
18 -14.200[R] COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II  ali follow..  11  1...................MGRMVVKVTIVGYRKGLIGYHGFSALVES--NGYKVLVDTGTDGKVLLNNMH---------------------------ELGIDANDIDVLFITHGHYDHTGGLKEFLKE--RSEPIEVYAHPGIFDALKPRKRDIGIPFQRKELEELGARFNLSPEPLEFLPGFISSG-EIKRVTWDRAVGYFPDGRKDPVRDDMALIVEGSKG---------------------------VVISGCGHSSKIAALIGGHLKKELLDDVVTNM--------KELGVNALYPGHC-----TGIEEFSYLWSKLD----------NVEGIYVGKEIKI 272
19 -12.400[C] COG0426 Uncharacterized flavoproteins  ali follow..  12  1MVSMSTTGNAHTENVQHRLTVETV-NTTAIRCLGLQNGTTYNSYLIR---GEQTVLVDTSHQLETLKGLI--------------------------------NPKAIDYIIVSHTEPDHSGLVEDVLQLA---PRATVLASKIALQFLEGLVHDPF-----------SKRIVKSGDRIDIGKGIEFVSAPNLHWPDTIFSYDR----------KTEVIYTCDA-DEDLEAIEADFRFYYDCLMGPNARSLLNAMKRMGDLGKIKIIANGHLLYHHLDVLTECYQSWSQRQAKSETTVGLF-------YVADYGYSNLLVQAIGEGIQKTGVAVEMIDLST...... 308
20 -12.100[R] KOG0814 Glyoxylase  ali follow..  15  17VSNIRYLSSFGTMSLPERQPFSPDFFFRQLFDG----ESSTYSYLLADLKNGQAVIIDPVL------------------------------QAKRDAQLVKDLGFELKYAINTHMHADHITGSGWLRKL---------TGCQSVIAAASGAKAD---------------RHLNEGDRIDF-GTHVIDALATPHTNG------CMTYVI----KDQGCVFTGDT---TDFQEGCPRNLYENVHSKIFTLPENFRIYP------------AH............................................................................ 212
21 -11.300[R] COG2333 Predicted hydrolase (metallo-beta-lactamase superfamily)  ali follow..  12  79....................SKPTWQVDTLDVGQG------LATLIVK--NGKGILYDTGSSWRGGS-----------------------MAELEILPYLQREGIVLEKLILSHDDNDHAGGASTILKAY-PNVELITPSRKNYGENYRTFCTAGRDW----HWQGLHFQILSPHNVVTRADN-------------------SHSCVILVDDGKNSVLLTGDAEAKDVLQVGHHGSKTSTSEYLLSQVRPDVAIISSGRWNP-----WKFPHYSVMER.................................................................... 288
22 -9.240[Q] COG2015 Alkyl sulfatase and related hydrolases  ali follow..  91.GLDYDSIHPSLQRQAQLNMHHGLYKVT--RIYQVRGYDLANITFVK--GDTGWIVFDPLTVPATAKAALD-------------------------FVNQELGERPVKAVVYSHAHADHFGGVGIVSQEQVDRGEVPIIAPKGFLNHAVAEN-TTYQYGNVLPKGATGQVDAAIGKNVAQGEVSLIAPTKVISEQTETVVIDGVTMEFQNTPGTESALWMAEN---GGLHNVYTLRGAEVRDAKAWSKYINESI---MYAKEADVMFASHTWPRWGNDNINHFLRKQRDMYGYIHDQAL-------RLANHGVTINEIQDEFH....................... 396
23 -9.130[A] KOG1138 Predicted cleavage and polyadenylation specificity factor (CPSF subunit)  ali follow..  25.................................WSNLPNFVPSRDHDPQMDG--ELKDCCGRVF-------------------------STPEFNLPMDKMLDFSEVDVILISN-YLNML-ALPYITENTGFKGK--VYATEPTLQ-IGRFFLEELV--KDVQGSLSKVTIMGYDEKLDILGAFIATPVSSGYCLG--------SSNWVLSTAHEKICYVSGSSTLTTHPRPINQS---------ALKHADVLIMTGLTQAPTVNRNNGSLIPCYPSGVVYDLFECLTQNLENAGLNNVPMFFISPVADSSLAYSNILAEWLSSAKQNK................. 329

FFAS is supported by the NIH grant R01-GM087218-01
1 3 9 8 0 4   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Jaroszewski L, Bierzynski A, Godzik A. Multiple model approach--dealing with alignment ambiguities in protein modeling. Pac Symp Biocomput. 1997;:328-39.