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Query: [J] COG5256 Translation elongation factor EF-1alpha (GTPase), from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKIMASQKPHLNLITIGHVDHGKSTLVGRLLYEHGEIPAHIIEEYRKEAEQKGKATFEFAWVMDRFKEERERGVTIDLAHRKFETDKYYFTLIDAPGHRDFVKNMITGTSQADAAILVISAREGEGVMEQTREHAFLARTLGVPQMVVAINKMDATSPPYSEKRYNEVKADAEKLLRSIGFKDISFVPISGYKGDNVTKPSPNMPWYKGPTLLQALDAFKVPEKPINKPLRIPVEDVYSITGIGTVPVGRVETGVLKPGDKVIFLPADKQGDVKSIEMHHEPLQQAEPGDNIGFNVRGIAKNDIKRGDVCGHLDTPPTVVKAFTAQIIVLNHPSVIAPGYKPVFHVHTAQVACRIDEIVKTLNPKDGTTLKEKPDFIKNGDVAIVKVIPDKPLVIEKVSEIPQLGRFAVRDMGQTVAAGQCIDLEKRLast
1 -124.000[J] COG5256 Translation elongation factor EF-1alpha (GTPase)  ali  100  1MKIMASQKPHLNLITIGHVDHGKSTLVGRLLYEHGEIPAHIIEEYRKEAEQKGKATFEFAWVMDRFKEERERGVTIDLAHRKFETDKYYFTLIDAPGHRDFVKNMITGTSQADAAILVISAREGEGVMEQTREHAFLARTLGVPQMVVAINKMDATSPPYSEKRYNEVKADAEKLLRSIGFKDISFVPISGYKGDNVTKPSPNMPWYKGPTLLQALDAFKVPEKPINKPLRIPVEDVYSITGIGTVPVGRVETGVLKPGDKVIFLPADKQGDVKSIEMHHEPLQQAEPGDNIGFNVRGIAKNDIKRGDVCGHLDTPPTVVKAFTAQIIVLNHPSVIAPGYKPVFHVHTAQVACRIDEIVKTLNPKDGTTLKEKPDFIKNGDVAIVKVIPDKPLVIEKVSEIPQLGRFAVRDMGQTVAAGQCIDLEKR 427
2 -118.000[J] KOG0052 Translation elongation factor EF-1 alpha/Tu  ali follow..  52  1...MGKEKVHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETAKYYITIIDAPGHRDFIKNMITGTSQADCAVLVVACGTGEFEAGQTREHALLAQTLGVKQLIVACNKMDSTEPPFSEARFTEITNEVSGFIKKIGYNAVPFVPISGFNGDNMLEVSSNMPWASGKTLLEALDSIIPPQRPTDRPLRLPLQDVYKIGGIGTVPVGRVETGIIKPGMVVTFAPQNVTTEVKSVEMHHESLPEAVPGDNVGFNVKNVSVKDIRRGSVCSDSKQPAKEARTFHAQVIIMNHPGQISNGYTPVLDCHTAHIACKFNELKEKVDRRTGKKVEDFPKFLKSGDAGIVELIPTKPLCVESFTDYAPLGRFAVRDMRQTVAVGVIKSVEKS 444
3 -104.000[P] COG2895 GTPases - Sulfate adenylate transferase subunit 1  ali follow..  30  19.MIAQQHKSLLRFLTCGSVDDGKSTLIGRLLHDTRQIYEDQLSSLHNDSKRHGTQGLDLALLVDGLQAEREQGITIDVAYRYFSTEKRKFIIADTPGHEQYTRNMATGASTCELAILLIDARKGVLD--QTRRHSFISTLLGIKHLVVAINKMDLVD--YSEETFTRIREDYLTFAGQLPGLDIRFVPLSALEGDNVASQSESMPWYSGPTLLEVLETVEIQRVVDAQPMRFPVQYVNRPNLDFRGYAGTLASGRVEVGQRVKVLPSGVESNVARIVTFDGDREEAFAGEAITLVL--TDEIDISRGDLLLAADEALPAVQSASVDVVWMA-EQPLSPGQSYDIKIAGKKTRARVDGIRYQVDINNLT--QREVENLPLNGIGLVDLTFDEPLVLDRYQQNPVTGGLIFIDSNVTVGAGMVHEPVSQ 440
4 -102.000[J] KOG0459 Polypeptide release factor 3  ali follow..  37  93.VAEANKKRHLNVVFIGHVDAGKSTIGGQILFLSGQVDDRQIQKYEKEAKDKSRESWYMAYIMDTNEEERLKGKTVEVGRAHFETESTRFTILDAPGHKSYVPNMISGASQADIGVLVISARKGEFETGQTREHVQLAKTLGVSKLIVVVNKMDDPTVNWSKERYDEIEQKMVPFLKASGYKDVVFLPISGLMGKNMDQRMGQCPWWSGPSFFEVLDSIEIPPRDPNGPFRMPIIDKFK--DMGTVVMGKVESGSIREGDSLVVMPNKEQVKVVAIYCDEDKVKRAGPGENLRVRITGIEDEDILSGFVLSSIVNPVPAVTEFVAQLQILEDNAIFTAGYKAILHIHAVVEECEIIELKSQIDLKTRKPMKKKVLFVKNGAAVVCRIQVTNSICIEKFSDFPQLGRFTLRTEGKTIAVGKVTELLSS 528
5 -101.000[J] KOG0458 Elongation factor 1 alpha  ali follow..  31  159.AFVKSALPHLSFVVLGHVDAGKSTLMGRLLYDLNIVNQSQLRKLQRESETMGKSSFKFAWIMDQTNEERERGVTVSICTSHFSTHRANFTIVDAPGHRDFVPNAIMGISQADMAILCVDCSTNAFESGQTKEHMLLASSLGIHNLIIAMNKMDNVD--WSQQRFEEIKSKLLPYLVDIGFDNINWVPISGFSGEGVYKIEYTRQWYNGPNLMSTLENAAFKGINKDDPFLFSVLEIIPTSNDLALVSGKLESGSIQPGESLTIYPSEQSCIVDKIQTNHEETDVAIKGDFVTLKLRKAYPEDIQNGDLAASVDYSIHSAQCFVLELTTFDMNRPLLPGTPFILFIGVKEQPARIKRLISFIDKGNTA-SKKKIRHLGSKQRAFVEIEVKRWIPLLTAHENDRLGRVVLRKDGRTIAAGKISEITQ. 611
6 -83.900[J] KOG0460 Mitochondrial translation elongation factor Tu  ali follow..  33  45.KVFVRKKPHVNIGTIGHVDHGKTTLTAAITKCLS---------------DLGQASFMDYSQIDKAPEEKARGITISSAHVEYETANRHYAHVDCPGHADYIKNMITGAATMDGAIIVVSATDGQM--PQTREHLLLARQVGVKQIVVYINKVDMVE----PDMIELVEMEMRELLSEYGFDGDNTPIVSGSALCALEGREPEIGLNSITKLMEAVDSYTLPERKTDVPFLMAIEDVFSISGRGTVVTGRVERGTLKKGAEIEIVGYGSKTTVTGIEMFKKQLDAAVAGDNCGLLLRSIKREQLKRGMIVAQPG-TVAPHQKFKASFYILTKRTGFVDKYRPQLYSRTSDVTVELTHPDP----------NDSDKMVMPGDNVEMICTLIHPIVIEKG------QRFTVREGGSTVGTALVTELLD. 439
7 -76.000[J] COG0050 GTPases - translation elongation factors  ali follow..  33  4.EKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLA---------------KTYGGSARAFDQIDNAPEEKARGITINTSHVEYDTPARHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDG--PMPQTREHILLGRQVGVPYIIVFMNKCDMVD---DEELLELVEMEVRELLSAYDFPGDDLPVVRGSALKALEGEAEW--EAKIIELAGYLDSYPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIVKVGEEVEIVGIKDKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREDIERGQVLAKPGS-IKPHTTFESEVYILSRHTPFFKGYRPQFYFRTTDVTGTIELP-------------EGVEMVMPGDNINMIVTLIHPIAMDDG------LRFAIREGGRTVGAGVVAKVI.. 393
8 -69.200[J] KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  19  33.HEVISRQATINIGTIGHVAHGKSTVVKAI---SGVHTVRFKNELERNITIKLGYANAKIYQLDDPSCPRPECYRSCGSSMPDEFPVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQ-PQTSEHLAAIEIMKLKHILILQNKIDLVK----ERQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNI------------EVVCEYIVKIPVPPRDFTSEPRLIVIRSFDVNKKGGVAGGSILKGVLKVGQETEVRPGIVSSKIVSLFAEHNDLQYAAPGGLIGVGTKTLCRADRMVGQILGAVGALPEIFTELEISYFLLRRLLGVRTEGDKK----AAKVQKLSKNEVLMVNIGSLSTGGR----VSAVKADLGKIVLTNPVCTEVGEKI--ALSRRVEKHWRLIGWGQIRRGVTI 465
9 -58.100[R] COG5258 GTPase  ali follow..  24  99.VSREEPPPTVTVVALGNVDAGKSTLVGVLTTDGKGLARSYASRYKHEVLTGRTSAVSLRLLGFSGDKVVNHGLIDPLDEAEYKRSDKLVLLVDVGGHERYLRTALRGLFQPDYVMLVVAANSG--VQKMTKEHLGIAVAIGIPVFVV-VTRIDIT----PSEVFQKTVEEVVRILKMPGVSKIPYIAAKAMPAGRVAPYVSSVTGHGLDLLLRFLSLLRRRRWDYGGEFLMYISDIYLVKGVGVVIGGLVEKGILHVGDRVWLGPYSDQTVVKSIHFNRTPVESAKAGSFITVALDKVEK--VEKGMVLSA--RPLKAVREVTADVLVLRHPTVIRAGFSGVFHYKAVRTGGYIKEI--------------DKGELMVGDSGVVKIELSRPWHIDS-------GVFVFRN-GPTRILGRIIGTDGT 514
10 -54.500[J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  22  2.....KNQSEINIGLVGHVDHGKTTLTKAL---SGVWTDTHSEETKRGSIRLGYADITFRKCPQCEAPMCYTTAEICERCGTETELLRKVSFVDAPGHETLMATMLSGAALMDGAILVIAANEP-CPQPQTKEHLMALDVIGVKDVIVVQNKIDIVS----KERALESYREIKEFVKGTCAEDAPIIPVSAQQGANI------------DILIETIEEIKTPKRDVDKPARMYVARSFDINKAGGVIGGSLVQGRLRVGDEIEIRPGIQVSTITGLVAGGEEMEEVGPGGLVGVGTLALTKADSLSGSVAGEPGTLPPVRHSFTMETHLLERVEPIKTGEPLMINVGTTTTVGVVK----------------------SARADDADVVLKLPACAEEGQ------RIALSARWRLIGYGIIK..... 408
11 -44.000[J] COG3276 Selenocysteine-specific translation elongation factor  ali follow..  23  1..........MIIVTSGHVDHGKTALLKALT-------------------------------TAHLPEEKKRGMTIDLGYAYLPLENKVLGFIDVPGHEKFLSNMLAGLGGVHYAMLIVAADEG--VAVQTKEHLAILRQLQFHEIIVVITKADRTNSAQIESLIQTIKQDYSFL------RNANYFVTSAETGQGI------------SELRHYLANL-AELADTQKPFRYAIDRVFSVKGAGTVVTGTAFSGTVKVNDEIYLST-GQKIRIKAIHAQNTSSEQGIAGQRLALNLNALDRTPMKRGDWLLQNEP-LPPTDRISVQI---LAEVPLNESQPVHIYHGASRTTGKLTLL--------------QGKNAAKNDRTLAEIILDSPLFLAFGD------KLILRSGDTLIAGARVLEINSP 346
12 -34.200[M] COG0481 Membrane GTPase LepA  ali follow..  25  2.......KNIRNFSIIAHIDHGKSTLSDRLIQTCGGLSDREMEA-----------------VLDSMDLERERGITITLNYKAKDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQG--VEAQTLANCYTAIEMNLE-VVPILNKIDLPAAD------ERVAEEIEDIV---GIDAMEAVRCSAKTGVGI-----------EDVLEEIVHKIPAPEGDPNAPLQALIIDSWFDNYLGVVSLVRIKNGTLRKGDKIKVMSTGQSYNVDRLGIKQVDTTILNCGEVGWVVCAIKDILGAPVGDTLTSHNNP............................................................................................................... 280
13 -33.800[T] COG1217 Predicted membrane GTPase involved in stress response  ali follow..  24  3.......ENLRNIAIIAHVDHGKTTLVDKLLKLSGTLDRKEAESER---------------VMDSNDQEKERGITILAKNTAIKWNGYNINIVDTPGHADFGGEVERVMSMVDSVLLVVDAQDG--PMPQTRFVTQKAFKAGLR-PIVVVNKIDRPGAR-----PDWVIDQIFDLFDNLGATDEQLFPISALNGIAGLDHEKMDDNMD-ALFQAIIDHVPAPVVDTEGPFQMQISQLDYNSFLGVIGIGRITRGKVKSNTPVVAISDDGSKRNGRILKQRVEVAEAEAGDIVCV----SGMEELFISDTLCDPQNVEALPP.......................................................................................................... 299
14 -32.800[J] KOG0462 Elongation factor-type GTP-binding protein  ali follow..  21  40.......DKIRNFGIVAHVDHGKSTLADRLLEMCGAVPPGQKQ------------------MLDKLQVERERGITVKAQTAALRHRGYLLNLIDTPGHVDFSAEVSRSLAVCDGILLLVAANQG--VQAQTIANFWLAFEKNIQ-IIPVINKIDLPGAD------KSVETQLKNLF--------------EFNPEECLHISAKSGLNVDKVLEAIIDRVPAPTAIIDAPFRSMIFDSYFDHFRGAIAHIMVKEGSVKKGDKIQSYQNEKVYDVSEVMVKCTELRAGQVGYLVCN-MRTVNEAVV--GETLFAETTSRDSVKTFGVKPTVYAGLFPVETSDYESLKQAVERLCLNDPSVTVIPDSSKALGLGWRIGFLGVLHMEVFGARLSQEYDASVILCQPSV....................... 403
15 -26.900[J] COG4108 Peptide chain release factor RF-3  ali follow..  19  7.PYFGEVSKRRTFAIISHPDAGKTTITEKVLLFGRAI--QVAGTVKGRGSNQHA-------KSDWMEMEKERGISVTTSVMQFPYGDCLVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDAAKG--VEDRTRKLMEVTRLRDTPIVTF-MNKLDREIRDPME-LMDEVENELKIACSPILFLQGELTPVTALGNFGVDHMLDGLQWAPSPMPRQAAERVVEASEEKFTGFVFKIQANMDPKHRDRIAFVRIVSGTYKQGMKMNHVRLGKQVNISDAVTDRARAEEAFAGDIIGL----HNHGTIQIGDTFTQGET................................................................................................................ 386
16 -26.500[J] KOG0469 Elongation factor 2  ali follow..  20  11.ALMDRKRNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGSKAGETR---------------FTDTRKDEQERCITIKSTAISLKYNGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSG--VCVQTETVLRQAIAERIKPVLF-MNKMDRALLELQFQTFQRIVENINVIIATYGDDD-NVGFGSGLHGWAFTLKQFAEMYAGGDTMLQMIFHLPSPVTPNGPLMMYISKMVPTSDKGRFYAFGRVFSGKVATGMKARIQGPNYEKTIQRTILFIEPIEDIPSGNIAG--LVGVDQYLVKGGTITTYKDAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIFE-ESGEHIIAGAGELHEEDHACIPLKKSDPVV................................. 571
17 -24.900[J] KOG0468 U5 snRNP-specific protein  ali follow..  22  122ADLMDTPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQLR--------------YTDTLFTEQERGCSIKATPVTLKQKSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAAEG--VMLNTERLLKHAVQERQAITVC-INKIDRLILELKLP--QDAYFKLKHIVEEVN....................................................................................................................................................................................................................................................... 288
18 -23.000[J] COG0480 Translation elongation factors (GTPases)  ali follow..  19  1MARINPLEKVRNIGIAAHIDAGKTTTTERILFYSGII--HKIGEVHEGTA-----------VTDWMDQERERGITITAAAISTSWKDYQINIIDTPGHVDFTIEVERSMRVLDGVIAVFCSVGG--VQPQSETVWRQADRYKVPRIAF-INKMDRTGANFYR-VHEQMRDRLNDFKGIVDLVRKRAYMYNNDQGTDIEETDEAVAETDDDLMSKYFDGEPLTEEEIRSALRKGTIAKIMADPYGRLTFVRVYSGVLKKGSYVLNATKNKKERISRLVLDRQDVEELRAGDLGAA----LGLKDTLTGDTITDEGAPVILESLFIPEPVISVAVEPKTKNDMDKLSKALQSLSEEDPTFRVNVDPETNQTV......................................................... 446
19 -18.500[J] KOG0465 Mitochondrial elongation factor  ali follow..  18  63..DIGRCNKLRNIGISAHIDSGKTTFTERVLYYTKRI--KAIHEVRGRDN--------VGAKMDSMDLEREKGITIQSAATYCEGKNYHFNLIDTPGHIDFTIEVERALRVLDGAVLVVCAVSG--VQSQTVTVDRQMRRYNVPRVTF-INKMDRMGSDPFR-AIEQLNSKLSSLSGVVDLINRVAIYNKGDNGEIIEKGPETLADVDDEMAEMFLEEKEPTTQQIKDAIRTPV--KLEEGKYGQLTYVRVYQGRLRKGNYITNVKTGKKVKVARLVREMEDVDEVGSGE-----ICATFGIDCASGDTFTDGSVQYSMSS--------MYVPDAVVSLSITPNSKDASNFSKALNRFQKE-DPTFRVKFDPESKETIISGMGELHLEIYVERMRREYNVDCVTGKPQVSYRESITIPADFDYTHKK 561
20 -18.000[E] COG4917 Ethanolamine utilization protein  ali follow..  22  3...........RIAFVGSVGAGKTTLFNALQGNYTLARKTQ------------------------------------------AVEFNDKGDIDTPGHPRWYHALITTLQDVDMLIYVHGAND-----PESRLPAGLLDIGVSKRQIAVISKTDMPDAD---------VAATRKLLLETGFEE-PMFELNSHDPQSVQQ------------LVDYLASLTKQEEAGEKT...................................................................................................................................................................................................... 155
21 -17.900[J] KOG1145 Mitochondrial translation initiation factor 2 (IF-2; GTPase)  ali follow..  23  183............VTIMGHVDHGKTTLL------------DKFRKTQVAAVETG-------------------GITQHIGAFLVSLPSEKITFLDTPGHAAFSAMRARGAQVTDIVVLVVAADDG--VMKQTVESIQHAKDAQVP-IILAVNKCDKAEADPEKVKKELLAYDV--VCEDYG-GDVQAVPVSALTGDNLMA------------LAEATAEMLELKADPNGPVEGTVIESFTDKGRGLVTTAIIQRGTLRKGSVLVA--GKCWAKVRLM-FDENGKTIDEAYPSMPVGITGWRDL--SAGEEILEVESEPRAREVVDWR..................................................................................................... 447
22 -16.100[R] COG3596 Predicted GTPase  ali follow..  12  36.......HYEPVIGIMGKTGAGKSSLCNALFAGEVSPVSDV------------------------------AACTRDPLRFRLQIGEHFMTIVDLPGDTEYAALYREQLPRLDLILWLIKADDRALATDEHFYRQVIGEAYR-HKMLFVISQSDKAEPTSGGNILSTEQKQKICLLHELFQPVHPVCAVSVRLQWGLRVMAERM............................................................................................................................................................................................................................... 212
23 -15.700[R] KOG2486 Predicted GTPase  ali follow..  16  137...........EFALVGRSNVGKSSLLNSLVRRKRLA-----------------------------LTSKKPGKTQCI---NHFRINDKWYLVDLPGYNKFTKDYFLNRSTLVSVFLLVDASIP--VKPIDLEYASWLGQNQVP-MTLIFTKCDKRKKK-GGKKPEANIKEFQDLIQGFFETTPPWIMTSSVTNQGRDE------------ILLHMAQL................................................................................................................................................................................................................ 311
24 -15.300[R] COG1084 Predicted GTPase  ali follow..  20  154.NMPTVDLDAFTVVIAGFPNVGKSTLLRTLTGAEPEVAD---------------------------------FTTKGIQIGHLERKWKRIQVIDTPGLLDELQAMVALENIADVIMFIFDASETCGYTLESQYSLYLIRSVFDIPVVTVFNKMDLAENVKYLEEYINMVEDP--------------LKVSAFEGRGVSKIIKKL............................................................................................................................................................................................................................... 321
25 -15.100[J] COG0532 Translation initiation factor 2 (IF-2; GTPase)  ali follow..  20  448............VTIMGHVDHGKTTLL------------DRFRESRVTEGEAG-------------------GITQHIGAYQIKANGKKITFLDTPGHEAFTSMRARGASVTDITILVVAADDG--VMPQTIEAINHSKAAGVP-IIVAINKIDKPGAN------QRVTQELTEH----PENGSEFVEISAKFNQNLDE------------LLDTVAEVQELKADPTVRAIGTVVEARLDQGKGAIATLLVQQGTLHVQDPIVV--GNTYGRVRTM-TNDLGRRIKEAGPSTPIELTGLSDV--QAGDHFAVFEDEKAARAAGEERAKRAQLIKRQNTRRVNLDNLFDTLKEGQTKSVNIIIKADVQGSAEALAASLQKIEVEGVKVDI-----------HSAVGAISESDISLAAASNAII..... 799
26 -15.000[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  16  46SIRLFRRTKSNTVLLSGLSGSGKTVLFYQLRD--GSSHQGAVTSMEPNEGT----------------------FVLHNENNTKKGKVKPVHLIDVPGHSRLISKLEEYLPRAAAVVFVVDALEFLPNIRAASEYDILTNASVIKNVLLCCNKTDKVTAHTKEFIRKQMEKEIDKL............................................................................................................................................................................................................................................................ 201
27 -12.900[R] COG1159 GTPase  ali follow..  16  11............IAIVGRPNVGKSTLLNKLLGQKISITSRKAQTTR----------------------HRIVGI--------HTEGPYQAIYVDTPGNRLMNKAASSSIGDVELVIFVVEGTRWTPDDEMVLNKLRDGK----APVILAVNKVDNVQEK------VDLLPHLQFLASQMNFLDI--VPISAETGMNVDTIAGIVHHFPEDYITDRSQRFMASEIIREKLMRFLGAELPYSVTVEIERFVTNERGGYDINGLILVEREGQKKKIKTIGIEARKDMQEMFEAPVHLEL................................................................................................................................... 277
28 -12.800[R] COG1160 Predicted GTPases  ali follow..  13  6............VALVGRPNVGKSTLFNRLTRTRDALVADF------------------------------PGLTRDRKYGHAHIAGYDFIVIDTGGEEKMAEQSLLAIDEADIVLFLVDARAG--LTAADIGIANYLRQRQNKITVVVANKTDGIDADSHCAEFYQL-----------GLGEI--EQIAASQGRGVADENDRTSEEEQDEWEQEFDFDSEEDTALIDDALDEELEEEQDKNIKIAIVGRPNVGKSTLTNRILGEDRVVVFDMPGTTRDSIYIPMERDGQQYTL----IDTAGVRKRGKVHLAVEKFSVIKTLQA-LLTIDARENISDQDLSLLGFILNAGRSLVI-VVNKWDGLDQDVKDRVKSELDRRFIDFARVHFISALHGSGVGNLFDSIKEAYACATQKMTTSLLTRILQM 403
29 -12.100[U] KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1  ali follow..  15  11LASLGLWQKEAKILFLGLDNAGKTTLLHML----------------------------------KDERLVQHQPTQHPTSEELSIGKIKFKAFDLGGHQIARRVWKDYYAKVDAVVYLVDAYDKERFAESKRELDALLSDEALATFLILGNKIDIPYAASEDELRYHLTGKGKVTLGDSGVRPLEVFMCSIVRKMGY---GEGFKW............................................................................................................................................................................................................................. 187
30 -12.100[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  13  165......DPNTRTVLICGYPNVGKSSFMNKV-----------------TRADVDVQPYAFT--------------TKSLFVGHTDYKYLRYQVIDTPGILD---TALAHLRAAVLFFLDISGSCGYTIAQQAALFHSIKSLFMNKPLVIVCNKTDLMPMENISEEDRKLIEEMKSEAMKTAMEEQVLLKMSTLTDEGVMSVKNAA............................................................................................................................................................................................................................... 345
31 -12.000[R] KOG0075 GTP-binding ADP-ribosylation factor-like protein  ali follow..  20  18.......KEEMELTLVGLQFSGKTTFVNVI--ASGQFAEDMIP-------------------------------TVGFNMRKITRGNVTIKVWDIGGQPRFRSMWERYCRGVNAIVYMVDAADLDKLEASRNELHSLLDKPQLAGVLVLGNKRDLPGALDETGLIERMN------LSSIQDREICCYSISCKEKDNI---DITLQW............................................................................................................................................................................................................................. 176
32 -12.000[R] COG2229 Predicted GTPase  ali follow..  16  2........RENKIIFTGPVGVGKTTAIAAI-------------------SDEALVQTDASASDMTLDRKRNTTVAMDYGAISLD-EDTKVHLYGTPGQERFNFMWEILSQGSMGLVLLLDNARTNPLKDLEFFLHSFRGLLEKAPVVVGITKMDIRSQPGIDVYHKYLAKH----------LNVPVFEIDARKEDDVKQ.................................................................................................................................................................................................................................... 163
33 -11.900[R] COG0218 Predicted GTPase  ali follow..  12  27...........EIALAGRSNVGKSSFINTML---------NRKNLARTSGKPGKTQLLNFFNIDD-----------------------KMRFVDVPGYGCMIEEYLTTRENLRAVVSLVDLRHDPSADDVQMYEFLKYYEI---PVIIVATKADKIPRGKWNKHESAIKKKLNF-------PSDDFILFSSVSKAGMDE.................................................................................................................................................................................................................................... 186
34 -11.700[UZ] KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2  ali follow..  18  7LKKMKQKERELRLLMLGLDNAGKTTILKKF----------------------------------NGEDIDTISPTLGFNIKTLEHRGFKLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSADRQRMQDCQRELQSLLVEERLAGLLIFANKQDLPGALSSNAIREALE------LDSIRSHHWCIQGCSAVTGENL---LPGIDW............................................................................................................................................................................................................................. 171
35 -11.700[R] COG1100 GTPase SAR1 and related small G proteins  ali follow..  16  9FDKLWGSNKELRILILGLDGAGKTTILYRL----------------------------------QIGEVVTTKPTIGFNVETLSYKNLKLNVWDLGGQTSIRPYWRCYYADTAAVIFVVDSTDKDRMSTASKELHLMLQEEELQDLLVFANKQDQPGALSASEVSKELN------LVELKDRSWSIVASSAIKGEGI---TEGLDW............................................................................................................................................................................................................................. 173
36 -11.700[U] KOG0070 GTP-binding ADP-ribosylation factor Arf1  ali follow..  16  8LFSRLFAKKEMRILMVGLDAAGKTTILYKL----------------------------------KLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRDRVVEARDELHRMLNEDELRDLLVFANKQDLPNAMNAAEITDKLG------LHSLRQRHWYIQSTCATSGEGL---YEGLDW............................................................................................................................................................................................................................. 172
37 -11.600[R] KOG0074 GTP-binding ADP-ribosylation factor-like protein ARL3  ali follow..  17  8RKLKSAPDQEVRILLLGLDNAGKTTLLKQL----------------------------------ASEDISHITPTQGFNIKSVQSQGFKLNVWDIGGQRKIRPYWKNYFENTDILIYVIDSADRKRFEETGQELAELLEEEKLSCVLIFANKQDLLTAAPASEIAEGLN------LHTIRDRVWQIQSCSALTGEGV---QDGMNW............................................................................................................................................................................................................................. 172
38 -11.600[U] KOG0071 GTP-binding ADP-ribosylation factor Arf6 (dArf3)  ali follow..  13  18......SNKEMRILMLGLDAAGKTTILYKL----------------------------------KLNQSVVTIPTVGFNVETVTYKNIKFNVWDVGGQDKIRPLWRHYFTGTKGLIFVVDSADSNRISEARQELHRIISDREMRDLLVLANKQDLPGALSPAQITDVLQ------LDKLKDRLWNVQPTCALTGDGL---LEGLAW............................................................................................................................................................................................................................. 176
39 -11.600[U] KOG0072 GTP-binding ADP-ribosylation factor-like protein ARL1  ali follow..  18  14......GSREMRILILGLDGAGKTTILYRL----------------------------------QVGEVVTTIPTIGFNVEQVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAIIYVVDSADRDRIGISKDELLYMLREEELAGLVVLANKQDMDGCMTVAEVHHALG------LENLKNRTFQIFKTSATKGEGL---DQAMDW............................................................................................................................................................................................................................. 172
40 -11.500[T] KOG3886 GTP-binding protein  ali follow..  10  32.WVLPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATILDRIHSLQINSSLSTYSLVDSVGNTKTFDVEHSHVRF-LGNLVLNLWDCGGQDTFMENYFTSQRDVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECS------RTSIWDETLYKAWSSI-----YQLIPNVQQLEMNLRNFAEIIEADEVLLFERAT......................................................................................................................................................................................... 271
41 -11.500[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali follow..  16  8LYNNWNKKEQYSILILGLDNAGKTTFLETLKKEYSLAFKALEKIQP----------------------------TVGQNVATIPVDSQILKFWDVGGQESLRSMWSEYYSLCHGIIFIVDSSDRERLDECSTTLQSVVMDEEIEGILMLANKQDRQDR-----EVQDIKEVFNKIAEHISARDSRVLPISALTGEGV---KDAIEW............................................................................................................................................................................................................................. 181
42 -11.000[F] COG1618 Predicted nucleotide kinase  ali follow..  16  1MRIEGKEKTMLRIAVTGSPGVGKSTVVAKTAEKLAEKPGFKIGGIRTAEIRKEGHREGFSIR------DLATGKTGILSHVKGSGPRLGKYHVNLDDLERIGANAVRNALACD--LVVID-EIGPMELISQSFVSAVEEVLESDKPVLAVFRKGFEVLTVDKGNRDELPEKITNRFLR......................................................................................................................................................................................................................................................... 181
43 -10.700[R] KOG1533 Predicted GTPase  ali follow..  14  25.NLGSTHWTMYGVLVIGAPGAGKSTFCAGLTDIFSQTKRPNLDPANDTMAYAPDVNITEMITVNDVMDRLGLG-NCNWLLQKIEANHKKYLIIDCPGSEGELWKVIRFLEKSGVRLCALHLADSLYCSDPSKFISVALSTLATMPQVNCLSKADLFSEDGTYDKYRKLNEAICGVISD--FDLVSFVPLAVENKESMMK------------VIQMVDAA................................................................................................................................................................................................................ 280
44 -10.600[U] KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily  ali follow..  20  4.PAANGEVPTFKLVLVGDGGTGKTTFVKR-------------------------------HLTGEFEKKYIATIGVEVHPLSFYTNFGKFDVWDTAGQEKFGGLRDGYYINAQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKE--------RKVKAKTITFHRKKN---LQYYDISAKSNYNFEK.................................................................................................................................................................................................................................... 161
45 -10.600[O] KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis  ali follow..  15  72......SRRHMKVAFFGRTSSGKSSVINAMLWDTNCFGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKAKCARDDLVLVDSPGLDSWIDKFC---LDADVFVLVANSES---TLMNTEKHFFVNEWLSKPNIFILNNRWDASASEVRRQHMERCLHFLVEELKVAN-AQNRIFFVSAKEV......................................................................................................................................................................................................................................... 288
46 -10.500[U] KOG3887 Predicted small GTPase involved in nuclear protein import  ali follow..  14  58.....STEVKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLES------------------------------TNKICREDVSSSFVNFQIWDFPGQIDFFDPTFD--RGTGALIFVIDSQDDYMEALARLHLTVTRAY----NFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKIHLS-LTSIYDHSIFEAFSKV-----QKLIPQLPTLE............................................................................................................................................................................................................... 245
47 -10.200[R] KOG1489 Predicted GTP-binding protein (ODN superfamily)  ali follow..  17  337.......KSIADLGLIGLPNAGKSTILNKISNAKPKIGHWQFTTLSP-----------------------------TIGTVSLGFGQDVFTVADIPG-------IIQGASRSNGWVFVLDLSNKN-DLQLLIEEVGTLEKVKTKNILIVCNKVDIDA---EKSESFAKYLQVEKFSKS---QEWDCVPISALREKT....................................................................................................................................................................................................................................... 499
48 -10.100[P] COG0370 Fe2+ transport system protein B  ali follow..  15  2........SQNTYCILGNPNTGKTSLFNALTGSYEYVGN--------------------------------SGVTVEKKVGTLR--SKTGKLIDLPGDETVVTRFLLE-EKFDCMLNIVDSS-------QIERNLNLTVQL--APVVMGLNMIDVAAGRGIHLNIQNLAKKL----------RIPILPVVARSGKGTEDILSTL............................................................................................................................................................................................................................... 157
49 -9.920[R] KOG1673 Ras GTPases  ali follow..  16  93.SSSDSDLVSLKISLLGDCQTGKTTFVVKYVGDENQSFLEMT------------------------------GLNLMDKTFYVQGVTISFSIWDVGGDEKRSKDHIPIACKDAVAILFMFDLTSRSTLNSVFGWYSQARKWNKTAIPILITKFDDF-VRLPPNLQWTIVTQARAYAKVMN---ASLFFSSATHNINVNK.................................................................................................................................................................................................................................... 257
50 -9.550[K] KOG1534 Putative transcription factor FET5  ali follow..  14  4..........VAAFVCGVASSGKSTFCGALMSYMKSVGRSNLDPAAENFEWEPTVDIRDLISIDDVMEELDYGENLDWLNEEIGDYDEDYLIFDMPGQIELIRHLQVTLNFRPCAVYLLESDRTKFFAGVLSAMSAMVM-MEVPHINL-LSKMDLLKDNNNITKFHELNRCIVQLIDD--FNMVNFLPLESGNEESVSR------------VLSYIDDA................................................................................................................................................................................................................ 252
51 -9.520[R] KOG0395 Ras-related GTPase  ali follow..  20  15.....PAKNSYRMVVLGASRVGKSSIVSRF------LNGRFEDQYTP-----------------TIEDFHRKVYNIR-------GDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVKSCLKMVICGNKNDHGELC------RQVPTTEAELLVSGDE-NCAYFEVSAKKNTNVDE.................................................................................................................................................................................................................................... 181
52 -9.140[TU] KOG1954 Endocytosis/signaling protein EHD1  ali follow..  18  95............ILLVGQYSTGKTTFIRYLL-----------SDFPGIRIGPEPTTDRFIAVMHGDEEGSIPGNALVVALSGFGNA-ESVTIVDTPG--DFTGVLEWFAERVDRIILLFDAHK----LDISDEFKRCIEAL--DKIRIVLNKSDMVDHQQLMRVYGALMWSLGKVFKT......................................................................................................................................................................................................................................................... 280

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Harder T, Godzik A. JAFA: a protein function annotation meta-server. Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W379-81.