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Query: [J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase), from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKNQSEINIGLVGHVDHGKTTLTKALSGVWTDTHSEETKRGISIRLGYADITFRKCPQCEAPMCYTTAEICERCGTETELLRKVSFVDAPGHETLMATMLSGAALMDGAILVIAANEPCPQPQTKEHLMALDVIGVKDVIVVQNKIDIVSKERALESYREIKEFVKGTCAEDAPIIPVSAQQGANIDILIETIEERIKTPKRDVDKPARMYVARSFDINKPGADPEHLAGGVIGGSLVQGRLRVGDEIEIRPGIQVKKDGKQTWMSLHSTITGLVAGGEEMEEVGPGGLVGVGTLLDPALTKADSLSGSVAGEPGTLPPVRHSFTMETHLLERVVGTKEETKVEPIKTGEPLMINVGTTTTVGVVKSARADDADVVLKLPACAEEGQRIALSRRVGARWRLIGYGIIKLast
1 -121.000[J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali  100  1MKNQSEINIGLVGHVDHGKTTLTKALSGVWTDTHSEETKRGISIRLGYADITFRKCPQCEAPMCYTTAEICERCGTETELLRKVSFVDAPGHETLMATMLSGAALMDGAILVIAANEPCPQPQTKEHLMALDVIGVKDVIVVQNKIDIVSKERALESYREIKEFVKGTCAEDAPIIPVSAQQGANIDILIETIEERIKTPKRDVDKPARMYVARSFDINKPGADPEHLAGGVIGGSLVQGRLRVGDEIEIRPGIQVKKDGKQTWMSLHSTITGLVAGGEEMEEVGPGGLVGVGTLLDPALTKADSLSGSVAGEPGTLPPVRHSFTMETHLLERVVGTKEETKVEPIKTGEPLMINVGTTTTVGVVKSARADDADVVLKLPACAEEGQRIALSRRVGARWRLIGYGIIK 408
2 -107.000[J] KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  45  36ISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYQLDDPSCPRPDEFPTDIPGTKGNFRLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKERQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQETEVRPGIVSDSEGKLMCKSIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQILGAVGALPEIFTELEISYFLLRRLLGVRTEAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQI. 459
3 -83.400[J] COG0050 GTPases - translation elongation factors  ali follow..  28  8.RTKPHVNVGTIGHVDHGKTTLTAAITTVQIDNAPEEKARGITINTSHVEYDTPA--------------------------RHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGP-MPQTREHILLGRQVGVPYIIVFMNKCDMVDEELLELVEMEVRELLSAYDFPGDDLPVVRGSALKALEELAGYLDSYIPEPERAIDKPFLLPIEDVFSISG--------RGTVVTGRVERGIVKVGEEVEIVGIKDT----------VKSTCTGVEMFRKLLDEGRAGENVGVLLR---GIKREDIERGQVLAKPGSIKPH-TTFESEVYILSKDEGGRH----TPFFKGYRPQFYFRTTDVTGTIMPGDNINMIVTLIHPIAMDDGLRFAIR----EGGRTVGAGVV. 389
4 -81.800[J] KOG0460 Mitochondrial translation elongation factor Tu  ali follow..  25  49.RKKPHVNIGTIGHVDHGKTTLTAAITKCQIDKAPEEKARGITISSAHVEYETAN--------------------------RHYAHVDCPGHADYIKNMITGAATMDGAIIVVSATDGQ-MPQTREHLLLARQVGVKQIVVYINKVDMVEPDMIELVEMEMRELLSEYGFDGDNTPIVSGSALCALEKLMEAVDSYITLPERKTDVPFLMAIEDVFSISG--------RGTVVTGRVERGTLKKGAEIEIVGYG----------SHLKTTVTGIEMFKKQLDAAVAGDNCGLLLR---SIKREQLKRGMIVAQPGTVAPH-QKFKASFYILTKEEGGRR----TGFVDKYRPQLYSRTSDVTVELTPGDNVEMICTLIHPIVIEKGQRFTVR----EGGSTVGTALV. 434
5 -73.300[J] COG3276 Selenocysteine-specific translation elongation factor  ali follow..  28  1......MIIVTSGHVDHGKTALLKALTGTSTAHLPEEKKRGMTIDLGYAYLPLENK--------------------------VLGFIDVPGHEKFLSNMLAGLGGVHYAMLIVAADEGV-AVQTKEHLAILRQLQFHEIIVVITKADRTNSAQIESLIQTIKQDY--SFLRNANYFVTSAETGQGISELRHYLANLAE--LADTQKPFRYAIDRVFSVKGA--------GTVVTGTAFSGTVKVNDEIYLSTG-------------QKIRIKAIHAQNTSSEQGIAGQRLALNLN--ADLDRTPMKRGDWLLQNEPLPPT-DRISVQILAE------------VPLNESQPVHIYHGASRTTGKLTKNDRTLAEIILDSPLFLAFGDKLIL--RSGDTKTLIAGARV. 340
6 -61.600[R] COG5258 GTPase  ali follow..  21  103.EPPPTVTVVALGNVDAGKSTLVGVLTTGRLDRYKHEVLTGRTSAVSLRLLGFSGDKVVNHGLIDPLDEAEV----YKRSDKLVLLVDVGGHERYLRTALRGLFSPDYVMLVVAANSGV-QKMTKEHLGIAVAIGIP-VFVVVTRIDITPSEVFQKTVEEVVRILKMPGVSKAPVFYVSSVTGHGLDLLLRFLSLLPRRRRWDYGGEFLMYISDIYLVKG--------VGVVIGGLVEKGILHVGDRVWLGPYSDGK---------MQTVVKSIHFNRTPVESAKAGSFITVA------LDKVEKVEKGMVLSARPLKAV-REVTADVLVLRH---------PTVIRAGFSGVFHYKAVRTGGYIKVGDSGVVKIELSRPWHIDSG-VFVFRN-----GPTRILGRI. 508
7 -54.500[J] COG5256 Translation elongation factor EF-1alpha (GTPase)  ali follow..  22  6.SQKPHLNLITIGHVDHGKSTLVGRLHGEIPAHIIEEYRKE-AEQKGKATFEFAWVMDRFKEERERGVTIDLAHRKFETDKYYFTLIDAPGHRDFVKNMITGTSQADAAILVISAREGGVMEQTREHAFLARTLGVPQMVVAINKMDATSEKRYNEVKADAEKLLRSIGFKDISFVPISGYKGDNVPTLLQALDA-FKVPEKPINKPLRIPVEDVYSITG--------IGTVPVGRVETGVLKPGDKVIFLPADKQ------------GDVKSIEMHHEPLQQAEPGDNIGFNVR---GIAKNDIKRGDVCGHLDTPPTVVKAFTAQIIVLNH---------PSVIAPGYKPVFHVHTAQVACRIDNGDVAIVKVIPDKPLVIEKVSRFAVR----DMGQTVAAGQCI 422
8 -50.700[P] COG2895 GTPases - Sulfate adenylate transferase subunit 1  ali follow..  20  23.QHKSLLRFLTCGSVDDGKSTLIGRLLALLVDGLQAEREQGITIDVAYRYFS--------------------------TEKRKFIIADTPGHEQYTRNMATGASTCELAILLIDARKGV-LDQTRRHSFISTLLGIKHLVVAINKMDLVDEETFTRIREDYLTFAGQLPGLDIRFVPLSALEGDNVPTLLEVLET-VEIQRVVDAQPMRFPVQYVNRPNL--------DFRGYAGTLASGRVEVGQRVKVLPSGVE------------SNVARIVTFDGDREEAFAGEAITLVLT-----DEIDISRGDLLLAADEALPAVQSASVDVVWMAE----------QPLSPGQSYDIKIAGKKTRARVDLNGIGLVDLTFDEPLVLDRYQGLIFIDRLSN--VTVGAGMVH 435
9 -48.900[J] KOG0052 Translation elongation factor EF-1 alpha/Tu  ali follow..  22  3.KEKVHINIVVIGHVDSGKSTTTGHLCGGIDKRTIEKFEKE-AQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETAKYYITIIDAPGHRDFIKNMITGTSQADCAVLVVACGTGEFEAQTREHALLAQTLGVKQLIVACNKMDSTEEARFTEITNEVSGFIKKIGYNPKAVVPISGFNGDNMKTLLEALDS-IIPPQRPTDRPLRLPLQDVYKIGG--------IGTVPVGRVETGIIKPGMVVTFAPQNVT------------TEVKSVEMHHESLPEAVPGDNVGFNVK---NVSVKDIRRGSVCSDSKQDPKEARTFHAQVIIMNH---------PGQISNGYTPVLDCHTAHIACKFNSGDAGIVELIPTKPLCVESFTRFAVR----DMRQTVAVGVIK 439
10 -44.900[J] KOG0459 Polypeptide release factor 3  ali follow..  21  97.NKKRHLNVVFIGHVDAGKSTIGGQISGQVDDRQIQKYEKE-AKDKSRESWYMAYIMDTNEEERLKGKTVEVGRAHFETESTRFTILDAPGHKSYVPNMISGASQADIGVLVISARKGE--GQTREHVQLAKTLGVSKLIVVVNKMDDPSKERYDEIEQKMVPFLKASGYKDVVFLPISGLMGKNMPSFFEVLDS-IEIPPRDPNGPFRMPIIDKFK-----------MGTVVMGKVESGSIREGDSLVVMPNKEQ------------VKVVAIYCDEDKVKRAGPGENLRVRIT---GIEDEDILSGFVLSSIVNPVPAVTEFVAQLQILE--------LDNAIFTAGYKAILHIHAVVEECEIINGAAVVCRIQVTNSICIEKFSRFTLR----TEGKTIAVGKVT 523
11 -44.600[J] KOG0458 Elongation factor 1 alpha  ali follow..  19  163.SALPHLSFVVLGHVDAGKSTLMGRLLNIVNQSQLRKLQRE-SETMGKSSFKFAWIMDQTNEERERGVTVSICTSHFSTHRANFTIVDAPGHRDFVPNAIMGISQADMAILCVDCSTNA--GQTKEHMLLASSLGIHNLIIAMNKMDNVDQQRFEEIKSKLLPYLVDIGFFEDNIVPISGFSGEGVPNLMSTLENA-ENEGINKDDPFLFSVLEIIPSKKTSND-----LALVSGKLESGSIQPGESLTIYPSEQSCIVDKIQ----VGSQQGQSTNHEETDVAIKGDFVTLKLR---KAYPEDIQNGDLAASVDYSSHSAQCFVLELTTFD---------MNRPLLPGTPFILFIGVKEQPARIKSKQRAFVEIELKRWIPLLTAHRVVLR----KDGRTIAAGKIS 607
12 -30.400[M] COG0481 Membrane GTPase LepA  ali follow..  21  6.......NFSIIAHIDHGKSTLSDRLCGG-LDSMDLERERGITI---------------------KAQSVTLNYKAKDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQG-VEAQTLANCYTAIEMNLE-VVPILNKIDLPAAD-PERVAEEIEDIVG---IDAMEAVRCSAKTGVGIEDVLEEIVHKIPAPEGDPNAPLQALIIDS--------WFDNYLGVVSLVRIKNGTLRKGDKIKV-----MSTGQSYNVDRLGIFTPKQVDTTILNCGEVGWVVCAIK-------DILGAPVGDTLTSHNN............................................................................................ 279
13 -28.000[J] KOG0462 Elongation factor-type GTP-binding protein  ali follow..  20  37FTPDKIRNFGIVAHVDHGKSTLADRLCGA-LDKLQVERERGITVKAQTAALRHRG--------------------------YLLNLIDTPGHVDFSAEVSRSLAVCDGILLLVAANQGV-QAQTIANFWLAFEKNIQ-IIPVINKIDLPGAD-IKSVETQLKNLFE---FNPEECLHISAKSGLNVDKVLEAIIDRVPAPTAIIDAPFRSMIFDS--------YFDHFRGAIAHIMVKEGSVKKGDKIQSYQNEKVYDVSEVG------VMRPEMVKCTELRAGQVGYLVCNMRTV------NEAVVGETLFAETTIKGVKPTVYAGLFPVETSDYESLKQAVERLCLNDPSVTVIPDSSKALGLGWRIGFLGVLHME-----------VFGARLSQEYDA....... 394
14 -27.100[T] COG1217 Predicted membrane GTPase involved in stress response  ali follow..  24  7.......NIAIIAHVDHGKTTLVDKLSGT-MDSNDQEKERGITILAKNTAIKWNG--------------------------YNINIVDTPGHADFGGEVERVMSMVDSVLLVVDAQDGP-MPQTRFVTQKAFKAGLR-PIVVVNKIDRPGAR-PDWVIDQIFDLFDNLGATDFPIVYASALNGDNMDALFQAIIDHVPAPVVDTEGPFQMQISQL--------DYNSFLGVIGIGRITRGKVKSNTPVV-----AISDDGSKRNGRILKIMGHHGLQRVEVAEAEAGDIVCV-------SGMEELFISDTLCDPQN............................................................................................ 293
15 -25.500[J] KOG0469 Elongation factor 2  ali follow..  16  21.......NMSVIAHVDHGKSTLTDSLAGI-TDTRKDEQERCITIKSTAISLELEKKDLEFVKGENQFETVEVDGKKEKYNGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGV-CVQTETVLRQAIAERIKP-VLFMNKMDRALLE-LQLGAEELFQTFQRIVEN-PLMKVFMRKWLPAGDTMLQMIAFHLPSPVTAQKYRMEMLYEGPHDDE---VPTSDKGRFYAFGRVFSGKVATGMKARIQGPNYVPGKKEDLYEKTIQRTILMMGRFEPIEDIPSGNIAGLV-----GVDQYLVKGGTITTYKDA-AKNPADLPKLVEGLKRLAKSDPMVQCIFEESGEHIIAGAGELHLEICLKDLEEDHIPLKKSDPVVS......................... 572
16 -24.000[J] COG4108 Peptide chain release factor RF-3  ali follow..  13  17.......TFAIISHPDAGKTTITEKVLHAKSDWMEMEKERGISVTTSVMQFPYGD--------------------------CLVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDAAKGV-EDRTRKLMEVTRLRDTPI-VTFMNKLDREIREELELVLGASHEFDRELFLQGTPVFFGTALGNFGVDHMLDGLTQWAPSPMPRQAAERVVEASEEFVFKIQANMDPKHRDRIAFVRIVSGTYKQGMKMN--------HVRLGKQVNISDAVTFMAGDRARAEEAFAGDIIGL-------HNHGTIQIGDTFTQGETIPNFAPELFRRIRLRDPLKQKQLLKGLVQLSEEGAVQVFRPLQNNDLIVGAVGVLQFDVVVSR............................. 454
17 -23.300[J] KOG0468 U5 snRNP-specific protein  ali follow..  17  133.......NVALVGHLHHGKTTFVDCLILRYTDTLFTEQERGCSIK---------------------ATPVTLVLQDVKQKSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAAEGV-MLNTERLLKHAVQERQAI-TVCINKIDRLVDTTLSDTLAELNVRVSKEEMKSNIRPLLRLVCNRFMSGFVDMCVEHIKSPLENQYGTLMVHSSKMYPN-------DDCTFFQVLARIVSGTLHAGQEVRVLGENYTLQDEEDSRILQVGRLWVFESRYVELNRVPAGNWVLI-EGIDQCIVKTSTIVDINIIKIAVEPVNPSELPKMLDGLRKVNKSYPLLSTRVEESGEHVILGTGELYLDCVMHDLRKMYIDIKVADPVVA......................... 664
18 -22.800[J] KOG1145 Mitochondrial translation initiation factor 2 (IF-2; GTPase)  ali follow..  25  182.......VVTIMGHVDHGKTTLLDKFRKT---QVAAVETGGITQHIGAFLVSLPSG-------------------------EKITFLDTPGHAAFSAMRARGAQVTDIVVLVVAADDGV-MKQTVESIQHAKDAQVP-IILAVNKCDKAEAD-PEKVKKELLAVVCEDYGGDVQAVPVSALTGDNLMALAEATVALAEMLEADPNGPVEGTVIES--------FTDKGRGLVTTAIIQRGTLRKGSVLVA---------------KCWAKVRLMDENGKTIDEAYPSMPVGI.................................................................................................................... 418
19 -22.400[E] COG4917 Ethanolamine utilization protein  ali follow..  23  4........IAFVGSVGAGKTTLFNALQG---NYTLARKTQAVEF-------------------------------------NDKGDIDTPGHPRWYHALITTLQDVDMLIYVHGAND----PESRLPAGLLDIGVSKRQIAVISKTDMPDAD-----VAATRKLLLETGFEE-PMFELNSHDPQSVQQLVDYLASLTKQEE............................................................................................................................................................................................................... 150
20 -19.900[R] KOG2486 Predicted GTPase  ali follow..  17  138........FALVGRSNVGKSSLLNSLVR-RKRLALTSKKPGKTQCINHFRIN-----------------------------DKWYLVDLPGYNKFTKDYFLNRSTLVSVFLLVDASIP-VKPIDLEYASWLGQNQVP-MTLIFTKCDKRKKKKNEANIKEFQDLIQGFFETTPPWIMTSSVTNQGRDEILLHMAQLRNYWLKH............................................................................................................................................................................................................. 318
21 -19.500[J] COG0480 Translation elongation factors (GTPases)  ali follow..  15  12.......NIGIAAHIDAGKTTTTERILTAVTDWMDQERERGITITAAAISTSWKD--------------------------YQINIIDTPGHVDFTIEVERSMRVLDGVIAVFCSVGGV-QPQSETVWRQADRYKVPR-IAFINKMDRTGANFYRVHEEEIRSALRKGTIAGVPVLCGSAFKNKGVQLMLDAVVDYLPAPTEVPPIQGTLPNGDAIERRADDNEMADPYGRLTFVRVYSGVLKKGSYV---------NATKNKKERISRLVLMKADDRQDVEELRAGDLGAA-------LGLKDTLTGDTITDEGAPVILESVISVAVEPKTKNDMDKLSKALQSLSEEDPTFRVNVDPETNQTVIAGMGELHLEILVDRMLREFKVEANVGAPQVAYRETI...... 483
22 -18.700[R] COG0218 Predicted GTPase  ali follow..  18  28........IALAGRSNVGKSSFINTMLN-RKNLARTSGKPGKTQLLNFFNID-----------------------------DKMRFVDVPGYGCMIEEYLTTRENLRAVVSLVDLRHD-PSADDVQMYEFLKYYEIP-VIIVATKADKIPRGKWNKHESAIKKKLN--FDPSDDFILFSSVSKAGMDEAWDAILEKL................................................................................................................................................................................................................... 195
23 -17.900[J] COG0532 Translation initiation factor 2 (IF-2; GTPase)  ali follow..  20  447.......VVTIMGHVDHGKTTLLDRFRES---RVTEGEAGGITQHIGAYQIKANG--------------------------KKITFLDTPGHEAFTSMRARGASVTDITILVVAADDGV-MPQTIEAINHSKAAGVP-IIVAINKIDKPGAN------QRVTQELTEHGV-GSEFVEISAKFNQNLDELLDTVAEVQELKADPTVRAIGTVVE---------ARLDQGKGAIATLLVQQGTLHVQDPIEAGPSTPIELTGLSDVPQAGDHFAVFEDEKAARAAGKEGQTKSVNI-----IIKADV-QGSAEALAASLQKIEVE-GVKVDIVHSAVGAISESDISLAAASNAIIIGFNVRPTGLAREQAAQEEVDIRLHSIIYKVIEEVETAMRGMLDP-EIIGEAIVR 857
24 -17.500[R] COG3596 Predicted GTPase  ali follow..  12  36...HYEPVIGIMGKTGAGKSSLCNALFA---------GEVSPVSDV-------------------AACTRDPLRFRLQIGEHFMTIVDLPGDTEYAALYREQLPRLDLILWLIKADDRALATDEHFYRQVIGEAYRHKMLFVISQSDKAEPTSGGNILSTEQKLLHELFQPVHPVCAVSVRLQWGLRVMAERMIKCLPREPS.............................................................................................................................................................................................................. 221
25 -17.500[R] COG1084 Predicted GTPase  ali follow..  20  159..DLDAFTVVIAGFPNVGKSTLLRTLTGAEPE------------------------------ADYPFTTKGIQIGHLERKWKRIQVIDTPGNNIELQAMVALENIADVIMFIFDASETCGYTLESQYSLYLGIRSVIPVVTVFNKMDLAENVKYLEEYINMVE----------DPLKVSAFEGRGVSKIIKKLEGLYEKETREAH........................................................................................................................................................................................................... 333
26 -16.900[J] KOG0465 Mitochondrial elongation factor  ali follow..  17  72.......NIGISAHIDSGKTTFTERVVGAKMDSMDLEREKGITIQSAATYCS-----------------------DKEGKNYHFNLIDTPGHIDFTIEVERALRVLDGAVLVVCAVSGV-QSQTVTVDRQMRRYNVPR-VTFINKMDVVDRQLLIETLADVDDEMAEMFLEETPVLMGSALANTGIQPVLDAIVDYLPNPSEVLNTALDVSNNEAKVNLVPAVQEEGKYGQLTYVRVYQGRLRKGNYI---------NVKTGKKVKVARLVRMHSSEMEDVDEVGSGEICATFQKEDPTVKFDPESKETIISGMGEL-----HLEIYVERMRREYNVDCVTGKPQVSYRESITIPADFDYTHKKQSGGAGQYGRVIGTLSPVDDITKGNIFETA-------IVGGRI. 597
27 -16.000[R] COG2229 Predicted GTPase  ali follow..  19  1MRENKIIFTGPVG----GKTTAIAAITDASASDMTLDRKRNTTVAMDYGAISLDEDT-------------------------KVHLYGTPGQERFNFMWEILSQGSMGLVLLLDNARTNPLKDLEFFLHSFGLLEKAPVVVGITKMDIRSQPGIDVYHKYLAKH------LNVPVFEIDARKEDDVKQLVSAMLFSID.................................................................................................................................................................................................................. 173
28 -15.100[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali follow..  17  12WNKKEQYSILILGLDNAGKTTFLETLKKEYSLAFKALEKIQPTVGQNVATIPVDS-------------------------KQILKFWDVGGQESLRSMWSEYYSLCHGIIFIVDSSDRERLDECSTTLQSVEEIEGVPILMLANKQDRQDRMEVQDIKEVFNKIAEHISARDSRVLPISALTGEGVKDAIEWMIVRLERNKKSRPPIYK....................................................................................................................................................................................................... 198
29 -14.800[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  16  170.......TVLICGYPNVGKSSFMNKVTRADV-DVQPYAFTTKSLFVGHTDYK----------------------------YLRYQVIDTPG-EMCSITALAHLRAAVLFFLDISGSCGYTIAQQAALFHSIKLFMNKPLVIVCNKTDLMPMENISEEDRKLIEEMKSEAMEEQVLLKMSTLTDEGVMSVKNAACERL................................................................................................................................................................................................................... 349
30 -14.500[P] COG0370 Fe2+ transport system protein B  ali follow..  16  1...MSQNTYCILGNPNTGKTSLFNALTGS---YEYVGNWSGVTVEKKVGTLR----------------------------SKTGKLIDLPGDETVVTRFLLE-EKFDCMLNIVDSSQ------ERNLNLTVQLLEYGPVVMGLNMIDVAAGRGIHLNIQNLAKKL------RIPILPVVARSGKGTEDILSTLSEKHVAPAIPLVLQYGEPAEKAIK............................................................................................................................................................................................... 181
31 -13.300[R] COG1159 GTPase  ali follow..  22  11........IAIVGRPNVGKSTLLNKLLGQKISITSRKAQTTRHRIVGIH----------------------------TEGPYQAIYVDTPGNRLMNKAASSSIGDVELVIFVVEGTR--WTPDDEMVLNKLRDGKAP-VILAVNKVDNVQEKVDLLPHLQFLA----SQMNFLDIVPISAETGMNVDTIAGIVRKHLP.................................................................................................................................................................................................................. 174
32 -13.200[R] KOG0075 GTP-binding ADP-ribosylation factor-like protein  ali follow..  16  15IFWKEEMELTLVGLQFSGKTTFVNVIA-------SGQFAEDMIPTVGFNMRKI------------------------TRGNVTIKVWDIGGQPRFRSMWERYCRGVNAIVYMVDAADLDKLEASRNELHSLPQLAGIPVLVLGNKRDLPGALDETGLIERMN--LSSIQDREICCYSISCKEKDNIDITLQWLIQHSKSQSR.............................................................................................................................................................................................................. 186
33 -12.700[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  16  50FRRTKSNTVLLSGLSGSGKTVLFYQLR---DGSSHQGAVTSMEPNEG-------------------TFVLHNENNTKKGKVKPVHLIDVPGHSRLISKLEEYLPRAAAVVFVVDALE---IRAASEYLDILTNASVIKVLLCCNKTDKVTAHTKEFIRKQMEKEIDKSHCHNKVTVAEASGLTGETDQVQEFIREHVK.................................................................................................................................................................................................................. 259
34 -12.600[T] KOG3886 GTP-binding protein  ali follow..  11  40..KKKVLLMGKSG----GKTSMRSIIF----ANYIARDTRRLGATILDRIHSLQINSSLSTYSLVDSVGNTKTFDVEHSHVRVLNLWDCGGQDTFMENYFTSQRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQL................................................................................................................................................................................................................... 241
35 -11.900[R] COG1160 Predicted GTPases  ali follow..  18  211.EQDKNIKIAIVGRPNVGKSTLTNRILG---------EDRVVVFDM-------------------PGTTRDSIYIPMERDGQQYTLIDTAGEKFSVIKTLQAIQDANVVLLTIDARENI----SDQDLSLLGFI--RSLVIVVNKWDGLDQDVKDRVKSELDRRLD--FIDFARVHFISALHGSGVGNLFDSIKEAYACATQKMT........................................................................................................................................................................................................... 393
36 -11.800[R] KOG0074 GTP-binding ADP-ribosylation factor-like protein ARL3  ali follow..  20  14..PDQEVRILLLGLDNAGKTTLLKQL--------ASEDISHITPTQGF------------------------NIKSVQSQGFKLNVWDIGGQRKIRPYWKNYFENTDILIYVIDSADRKRFEETGQELAELEKLSCVPVLIFANKQDLLTAAPASEIAEGLN--LHTIRDRVWQIQSCSALTGEGVQDGMNWVCKNVNAKKK.............................................................................................................................................................................................................. 182
37 -11.500[UZ] KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2  ali follow..  19  11KQKERELRLLMLGLDNAGKTTILKKF--------NGEDIDTISPTLGFNIKTL------------------------EHRGFKLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSADRQRMQDCQRELQSLERLAGATLLIFANKQDLPGALSSNAIREALE--LDSIRSHHWCIQGCSAVTGENLLPGIDWLLDDISSRIFTAD........................................................................................................................................................................................................... 184
38 -11.500[V] KOG1707 Predicted Ras related/Rac-GTP binding protein  ali follow..  13  9SGSPKPIRIVVVGEKGSGKSSLIMAAARNTFHPNIPSLLPYTNLPS-----------------------------EFFPDRIPATVIDTSSRPEDKGKVVKEVRQADAIVLTFAFDR----PETLDRLSKYWLPLFRQIIVAGYEVDNKEAYNHFSIEQITSALMKQY-REVETSIQWSAQRLDQAKDVLYYAQKAVIDPNNVLKPRCIAALKRIFLL---DEELNELQKKCFDTPLVPCEIK..................................................................................................................................................................... 238
39 -11.300[U] KOG0072 GTP-binding ADP-ribosylation factor-like protein ARL1  ali follow..  16  12LLGSREMRILILGLDGAGKTTILY--------RLQVGEVVTTIPTIGF------------------------NVEQVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAIIYVVDSADRDRIGISKDELLYMEELAGAILVVLANKQDMDGCMTVAEVHHALG--LENLKNRTFQIFKTSATKGEGLDQAMDWLSNTLQSRK............................................................................................................................................................................................................... 181
40 -11.200[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  13  2...KRPLIIGVGGPVGAGKTMLIERLTKEDARILLNT---SVLPADRIAGVETGGCPHTAIREDASMNFAAIEEMCDKHPDLQLLFLESGGDNLSATFSPDLV---DFSIYIIDVAQGEKIPRKGGQGMIKS-------LFIINKVDLAPYVGANV---EVMKADTLKSRGNKDFFVTNLKTDEGLKSVADWIEKRLQLALLE............................................................................................................................................................................................................. 205
41 -11.100[U] KOG0071 GTP-binding ADP-ribosylation factor Arf6 (dArf3)  ali follow..  14  16LFSNKEMRILMLGLDAAGKTTILY--------KLKLNQSVVTIPTVGF------------------------NVETVTYKNIKFNVWDVGGQDKIRPLWRHYFTGTKGLIFVVDSADSNRISEARQELHRIREMRDCLLLVLANKQDLPGALSPAQITDVLQ--LDKLKDRLWNVQPTCALTGDGLLEGLAWLSQNAK.................................................................................................................................................................................................................. 182
42 -11.100[U] KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1  ali follow..  17  18...QKEAKILFLGLDNAGKTTLLHMLKDERLVQHQP--------------------------------TQHPTSEELSIGKIKFKAFDLGGHQIARRVWKDYYAKVDAVVYLVDAYDKERFAESKRELDALEALATVPFLILGNKIDIPYAASEDELRYHLKVTLGDSGVRPLEVFMCSIVRKMGYGEGFKWLSQYIN.................................................................................................................................................................................................................. 193
43 -11.100[U] KOG0070 GTP-binding ADP-ribosylation factor Arf1  ali follow..  16  12LFAKKEMRILMVGLDAAGKTTILY--------KLKLGEIVTTIPTIGF------------------------NVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRDRVVEARDELHRMDELRDAVLLVFANKQDLPNAMNAAEITDKLG--LHSLRQRHWYIQSTCATSGEGLYEGLDWLSNNIA.................................................................................................................................................................................................................. 178
44 -10.800[R] COG1100 GTPase SAR1 and related small G proteins  ali follow..  18  14.GSNKELRILILGLDGAGKTTILYRL--------QIGEVVTTKPTIGF------------------------NVETLSYKNLKLNVWDLGGQTSIRPYWRCYYADTAAVIFVVDSTDKDRMSTASKELHLMEELQDAALLVFANKQDQPGALSASEVSKELN--LVELKDRSWSIVASSAIKGEGITEGLDWLIDVIK.................................................................................................................................................................................................................. 179
45 -10.800[O] KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis  ali follow..  11  72..SRRHMKVAFFGRTSSGKSSVINAMLWDKV-EGTDGDKAYLMTEGSDEKKSVKT-HMDKDLKAGCLVRVFWPKAKCALLRDDLVLVDSPGLDSWIDKFCLDA---DVFVLVANSESTLMNTEKHFFHKVNEWLSKPNIFILNNRWDASASEPEYMEDVRRQHMERNALEAQNRIFFVSAKEV................................................................................................................................................................................................................................. 288
46 -10.600[R] KOG0395 Ras-related GTPase  ali follow..  17  21....RMVVLGASR----GKSSIVGRFEDQYTPTIEDFHRKVYNIR---------------------------------GDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDN----RESFDEVKRLQILEVKSMVICGNKNDHGELCR-QVPTTEAELLVSGDE--NCAYFEVSAKKNTNVDEMFYVLFSMAKLPHEM............................................................................................................................................................................................................. 196
47 -10.200[U] KOG3887 Predicted small GTPase involved in nuclear protein import  ali follow..  13  57FSTEVKPRILLMGLRRSGKSSIQKVV-----HKMSPNETLFLESTNKICREDV-----------------------SNSSFVNFQIWDFPGQIDFFDPTFD-FRGTGALIFVIDSQDDYMEALARLHLTVTRAYKVNNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAG-SFYLTSIYDHSIFEAFSKVVQKL................................................................................................................................................................................................................... 237
48 -10.200[R] KOG0394 Ras-related GTPase  ali follow..  17  10....KVIILGDSG----GKTSLMNQYV---NKKFSNQYKATIGADFLTKEVQFED------------------------RLFTLQIWDTAGQERFQSLGVAFYRGADCCVLVYDVNSMKSFENLNNWREEFLIQASPSFVLIGNKVDVDDGNSRVVSEKKAKAWCASK--GNIPYFETSAKVGTNVEEAFQCIAKDA................................................................................................................................................................................................................... 176
49 -10.100[R] KOG2485 Conserved ATP/GTP binding protein  ali follow..  21  30.........................................................................................PGHAAATRAIRNRLKLSDLVIEVRDAR----IPLSSANEDLQSQMSAKRRIIALNKKDLANPNVLNVIRFFKWT--RHFESSKQDCIAINAHSRSSVMKLLDLVELKLKEVIAREPTLLVMVV---------------------------GVPNVGKSALI--------------NSIHQIAAARFPVQERLKRATVGPLPGV-TQDIAGFKIAHRPSIYVLDSPGVLVPSIPDIETGLKLA............................................................................. 224
50 -10.100[R] KOG1673 Ras GTPases  ali follow..  15  102......LKISLLGDCQTGKTTFVVKYVGDENQSFLE------MTGLNLMDKTF----------------------YVQGVTISFSIWDVGGDEKRSKDHIPIAKDAVAILFMFDLTSRSTLNSVFGWYSQARKWNKTAIPILITKFDDFVRLPPNLQWTIVTQARAYAKVMNASLFFSSATHNINVNKIFKFILARL................................................................................................................................................................................................................... 266
51 -9.800[U] KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily  ali follow..  15  14....KLVLVGDGG----GKTTFVKRHL---TGEFEKKYIATIGVEVHPLSFYTNFGE-------------------------KFDVWDTAGQEKFGGLRDGYYINAQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCNKVDVKERKVKAKTITFHRK-------KNLQYYDISAKSNYNFEKPFLWLARKL................................................................................................................................................................................................................... 170
52 -9.780[R] KOG1489 Predicted GTP-binding protein (ODN superfamily)  ali follow..  20  334FELKSIADLGLIGLPNAGKSTILNKISNAKP-KIGHWQFTTLSPTIGTVSLG--------------------------FGQDVFTVADIPG-------IIQGASGMGLEFLVLDLSNKNPLNDLIEEVGTLEKVKTKNILIVCNKVDIDAKSESFAKYLQVEKFSKS---QEWDCVPISALREKT............................................................................................................................................................................................................................... 499
53 -9.710[R] KOG0091 GTPase Rab39, small G protein superfamily  ali follow..  17  11....RLILIGDST----GKSSLLKFFT---DGKFAELSDPTVGVDFFARLIEMKDGTQ------------------------KLQLWDTAGQERFRSITKSYYRNSVGVLLVYDISNHASFEHIPLWMMEAQRHIEPHRPVFACKLDLINAGGHREVTTEEAQKFAKQ--HGLHFVETSARSGANVEEAFRMVTQEV................................................................................................................................................................................................................... 175
54 -9.580[U] KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases  ali follow..  15  22....KLVLLGESA----GKSSLVLRFV---KGQFHEFQESTIGAAFLTQTVCLDD------------------------TTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALNKADLANKRAVD--FQEAQSYADDN---SLLFMETSAKTSMNVNEIFMAIAKKL................................................................................................................................................................................................................... 181
55 -9.400[F] COG1428 Deoxynucleoside kinases  ali follow..  14  1MEGVGNKVIVLAGMIGAGKSSYTELIANE-EMFYDDPKRWAFALQIYFLNTRFRSIKAALTDQNNRSIYEDALFTQINFEEGNISEPEMDTYLDLLDNMMEELAYMDLLIYLRGSEQTFDNPGLLDYYKHLSYDKSDTLVINIDEVDINKPSDAKYVMQLIHEKLK.................................................................................................................................................................................................................................................. 213
56 -9.350[U] KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily  ali follow..  20  11....KLVFLGDQS----GKTSIITRFM---YDKFDTTYQATIGIDFLSKTMYLED------------------------RTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDVANRLSFLNTSKWIEEVRNERAGDVIIVLNKTDLVEKRQVS--IEEGDSKGREY---GVMFIETSAKAGFNIKPLFRKIAAAL................................................................................................................................................................................................................... 170
57 -9.340[U] KOG0086 GTPase Rab4, small G protein superfamily  ali follow..  18  10....KFLVIGSAG----GKSCLLHQFI---ENKFKQDSNHTIGVEFGSRVVNVGG------------------------KTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLASPNIVVILNKKDLDPEREVT--FLEASRFAQEN---ELMFLETSALTGENVEEAFLKCARTI................................................................................................................................................................................................................... 169
58 -9.310[F] COG0572 Uridine kinase  ali follow..  13  4.KAHQCVIIGIAGASASGKSLIASTLYRELREQVGDQHIGVIPEDGYYKDQSHLSMEERVKTNYDHPSAMDHNLLLEHLQALKAG-VELPLYSYTEHTRKKETVHLEPKVIILEGILLLTDIRLRQEMNFSIFVDTPLDICLMRRMDSVMAQYQKTVRPMFLQFIEPSKQYADIIVPRGGKNRIAIDILKAKISQFFE.................................................................................................................................................................................................................. 213
59 -9.250[R] COG2262 GTPases  ali follow..  19  193.IKADVPTVSLVGYTNAGKSTLFNRITEARV----AADQLFATLDPTLRRIDVADVGETVLAD-------------------TVGFIHLPHD-AAFKATLQETRQATLLLHVIDAADVRVQENIEAVNTVLEEIDAHETLLVMNKIDMLEDFEPRIDRDEENK---------PIRVWLSAQTGAGIPQLFQALTERL................................................................................................................................................................................................................... 361
60 -9.250[R] KOG1533 Predicted GTPase  ali follow..  14  37......LVIGAPG---AGKSTFCAGLT----DIFSQTKRPFLTINLDPANDTMAYAPDVNITEMITVNDVMDRLGKIEANHKKYLIIDCPGSEGELWKVIRFLEKSGVRLCALHLADSLYCSDPSKFISVALSMEMPQ-VNCLSKADLFSEDGTYDLEFFSHLPDVNRLLDLVSFVPLAVENKESMMKVIQMVDAAN................................................................................................................................................................................................................... 281
61 -9.230[U] KOG0097 GTPase Rab14, small G protein superfamily  ali follow..  20  13....KYIIIGDMG----GKSCLLHQFT---EKKFMADCPHTIGVEFGTRIIEVSG------------------------QKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILNKADLEAQRDVT--YEEAKQFAEEN---GLLFLEASAKTGENVEDAFLEAAKKI................................................................................................................................................................................................................... 172
62 -9.220[T] KOG4252 GTP-binding protein  ali follow..  13  11....KMVVVGNGA----GKSSMIQRYC---KGIFTKDYKKTIGVDFLERQIQVND------------------------EDVRLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRGSFEAVSSWREKVVAEVGDIPTVLVNKIDLLDDSCIK--NEEAEALAKRL---RLRFYRTSVKEDLNVNEVFKYLAEKY................................................................................................................................................................................................................... 169
63 -9.200[R] KOG0088 GTPase Rab21, small G protein superfamily  ali follow..  15  14....KIVLLGEGC----GKSSLVLRFV---ENKFSCKHLSTIQASFQNKTVNVED------------------------CQADLHIWDTAGQEKYHALGPIYYRGSNGVLLVFDITDRKSFEKVKNWVLEIKTCLGNTAEILINKIDLEEERQVT--RQDAEAYAESE---GALYMETSAQDNVGISDAFESLTAKM................................................................................................................................................................................................................... 173
64 -9.170[U] KOG0095 GTPase Rab30, small G protein superfamily  ali follow..  20  11....KIVLIGNAG----GKTCLVRRFT---QGLFPPGQGATIGVGFMIKTVEING------------------------EKVKLQIWDTAGQERFRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYASNKVITVLNKIDLAERREVS--QQRAEEFSEAQ---DMYYLETSAKESDNVEKLFLDLACRL................................................................................................................................................................................................................... 170
65 -9.140[U] KOG0081 GTPase Rab27, small G protein superfamily  ali follow..  15  11....KFLALGDSG----GKTSVLYQYT---DGKFNSKFITTVGIDFREKRVVYRASGPDGATGRGQRI--------------HLQLWDTAGQERFRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYCENPDIVNKSDLEDQRVVK--EEEAIALAEKY---GIPYFETSAANGTNISQAIEMLLDLI................................................................................................................................................................................................................... 181
66 -9.090[U] KOG0087 GTPase Rab11/YPT3, small G protein superfamily  ali follow..  19  12....KTVLIGDSG----GKSNLLMRFT---RNEFNIESKSTIGVEFATRNIVLDN------------------------KKIKAQIWDTAGQERYRAITSAYYRGAVGALIVYDITKQSSFDNVGRWLKELREHADSNIVIMLNKTDLLHLRAVS--TEEAQAFAAE---NNLSFIETSAMDASNVEEAFQTVLTEI................................................................................................................................................................................................................... 171
67 -9.060[U] KOG0098 GTPase Rab2, small G protein superfamily  ali follow..  18  8....KYIIIGDTG----GKSCLLLQFT---DKRFQPVHDLTIGVEFGARMVTIDG------------------------KQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTSWLEDARQHSNSNMVIMLNKSDLEARREVK--REEGEAFAREH---GLVFMETSAKTAANVEEAFIDTAKEI................................................................................................................................................................................................................... 167

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Jaroszewski L, Bierzynski A, Godzik A. Multiple model approach--dealing with alignment ambiguities in protein modeling. Pac Symp Biocomput. 1997;:328-39.