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Query: [S] COG5305 Predicted membrane protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MFSLGNSFLPVPLDQAIAPDILLQPLQPNPASGIGDVIHNLITEDNHPPLYFVLVHLWMKLFPNQGELVSLLAARSFPALLGAVSIPLTYILGRLAFRSSLVGQLAAGMMAVSPYAVYLGQEVRHYTLAMIWVIASLSCLVIATRHIQNRTLLPFWLIILWVGINALGIATHYFFTLTLCAEALVLIFLAWQQSTQAKTLVFFSPLWWRIYAVAAGTAVAGLVWLPSILENRYRSSLTAWIQVQGIGLHLINPIFQAFAAWVTMIMLLPIESSQLAVVIASGLVMLIFAIWATPILVRGFKFQLQQPQTSLATQVFIGVVLGAIALFFILTYIFGVDITRGARYNFVYFPAVIILVGASLAVYWQTSKKAVMIIWLMGFVSAVTVICNLGYQKYYRPDLLVQIIQQNSQVPVLIATTHKTLVQTGEMMGIARELKLSSSQTSTQFLLAHQETDPSTSTVSLEKTLKQLPRPFDLWLVNFHAPTAAEVKQCLADTKSLTAVDGYEYKIYHCREKSRLast
1 -181.000[S] COG5305 Predicted membrane protein  ali  100  1MFSLGNSFLPVPLDQAIAPDILLQPLQPNPASGIGDVIHNLITEDNHPPLYFVLVHLWMKLFPNQGELVSLLAARSFPALLGAVSIPLTYILGRLAFRSSLVGQLAAGMMAVSPYAVYLGQEVRHYTLAMIWVIASLSCLVIATRHIQNRTLLPFWLIILWVGINALGIATHYFFTLTLCAEALVLIFLAWQQSTQAKTLVFFSPLWWRIYAVAAGTAVAGLVWLPSILENRYRSSLTAWIQVQGIGLHLINPIFQAFAAWVTMIMLLPIESSQLAVVIASGLVMLIFAIWATPILVRGFKFQLQQPQTSLATQVFIGVVLGAIALFFILTYIFGVDITRGARYNFVYFPAVIILVGASLAVYWQTSKKAVMIIWLMGFVSAVTVICNLGYQKYYRPDLLVQIIQQNSQVPVLIATTHKTLVQTGEMMGIARELKLSSSQTSTQFLLAHQETDPSTSTVSLEKTLKQLPRPFDLWLVNFHAPTAAEVKQCLADTKSLTAVDGYEYKIYHCREKSR 515
2 -32.200[O] COG4745 Predicted membrane-bound mannosyltransferase  ali follow..  10  19VTAAALLARLWALGRVAHQDEARVADWT---LQYMDLGAWQYRPIIHGPFLPHVNGVVFDVFG-----ATDFTMRLVVAVVGGLLPLTAWLYRTRL--SDVEVGALAVLLAANPVVLYYSRFMRNDLLLAGFMFTAVGLFVRFLDTHRAR------YLYASAVPFALAFTTKENSLLYPLCWLGALALVTDDRMAVAGATDTSRLAVVRRAAARIRHRAWRAKAALAGSALTAAVIVVSFYAPKPDLYRLFEQPGRA-------------------PAVLEAATIGTYHEFADLWASTSTVAHSYVAFLSHDLSVLVACTVVSVAAVVGYLANRYATETPRPLVSFAFYWGVFSVLGYPAVVDIAAAWTAVNALVPLAIPAAVGVGAVVRYGRR-------GAAAGDTAAVRLAVTVLVVSAAGMGAVAAETTYAHPQSPSNPLVQYAQPGGTMQPTIDDIQRAATATSGPFP-WYLS..................................... 496
3 -25.600[O] COG4346 Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  11  170.............................................EHPFLGKDIIALGM-LIED-----KPFYWRIPGIIEHALIVIIVTLVAYKITKSYLASSIAATFAALDPLLFATGIVAMLDIHVAFFIALFMLFLAL-------------DRIRLSGIALGLAAATKLSGAFAFPILWFKILKEKDLKEYLISGLVLPMVSFLIPEITIIKAIGSFSWHLSFKGEHPSEAPFWMWFVSLKPFPFHFDP----------------VYAVTDPILMISMIVFVFAVPYVS----------LRRKGLSEIFWMFWSIIAFFALQYI-----------LGGKTQFIFYPPGAVALGVISYEIIKWEYFERSLRIYLNYLRSIAKPLKKVIKR.......................................................................................................................... 477
4 -23.900[M] COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family  ali follow..  12  10LFAFIACYYLLPISTRWQPDETRYAEISREMLASGDWIVPHLLGLRYPIAGYWINSIGQWLFG-----ANNFGVRAGVIFATLLTAALVTWFTLRLWRDKRLALLATVIYLSLFIVYAIGTYAVLDPFIAFWLVAGMCSFWLAMQAQTWKGK--SAGFLLLGITCGMGVMTKGFLALAVPVLSVLPWVATQKRWKDLFIYG---------WLAVISCVLTVLPWGLAIAQREPN-------------------WHYFFWVEHIQRFALDDAQHRAPFWYYVPVIIAGSLPWLG--LPGALYTGWKNRKHSATVYLLSWTI--MPLLFFSVA-------GKLPTYILSCFASLAMLMAHYALLAAKNNPLALRINGWINIAFGVTGI................................................................................................................................. 357
5 -19.400[O] KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase  ali follow..  14  71FTALALFTRMYKIGNHVVWDEAH-------GKFGSYYLRHEFYHDVHPPLGKMLVGLSGYLAGYNGSYLDYVKMRLFNASFSALCVPLAYFTAKAIGFSLPTVWLMTVLVLFENSYSTLGRFILLDSMLLFFTVASFFSFVMFHNQRSKPFSRKWWKWLLITISLGCTISVKMVGLFIITMVGIYTVIDLWTADKSMSWKTYINHWLARIFGLIIVPFCIFLLCFKIHFDLLSHSG....................................................................................................................................................................................................................................................................................... 315
6 -19.200[O] COG1928 Dolichyl-phosphate-mannose--protein O-mannosyl transferase  ali follow..  16  64FTVLGMFTRMYKIGNHVVWDEAH-------GKFGSYYLRHEFYHDVHPPLGKMLVGLSGYLAGYNGDYIDYVKMRLFQAMFSSLCVPLAYFTGRAIGFSRLSVWLFTILVIFENSYATLGKFILLDSMLLFFTVSSYFCLAKFHTMRKSPFSARWWLWLCLTLNLGCAISVKMVGLFIISVVGIYTILWNLLSDRSVSWKVYVNHWLARIFGLIIIPVCVFLLCFKIHFDLLSNSG....................................................................................................................................................................................................................................................................................... 309
7 -16.200[O] KOG2292 Oligosaccharyltransferase, STT3 subunit  ali follow..  10  27AWLAGFSSRLFAVIRFESIDPWFNYRATA-QNGWYNFLNWFDERAWYP-LMITSGGIHWLLHVLNIPVHIRDICVFLAPIFSGLTSISTYLLTKELW-SAGAGLFAASFIAIVPGYISRSV-YDNEGIAIFALQFTYFLWVRSVKTGSVFWS------AAAALSYFYMVSAWGGYVFIINLIPLHVFVLLIMGRYSPRLLTSYSTFYILGLLFSMQIHMAALGVFVLLMAVATLRHLQSVLSRNEFRKLFIVGGLLVGVGVFVAVVVLTMLGVVAPWSGRFYSLWDTGYAKIHIPIIASVSEHQPTTWFSFFFDLHILVCAFPVGVWFVVLYAI---AGVMVRLMLTLTPVVCMLAGVAFS.......................................................................................................................................................... 424
8 -14.900[R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation  ali follow..  9  32IAVASVSSRLFSVIRY--FDPWFNFRASKIEQGFYNFLNWFDERSWYP-LMVTSGIIFKVLHLLRINVNIRDVCVLLAPAFSGITAIATYYLARELK-SDACGLLAAAFMGIAPGYTSRS--YDNEAIAITLLMSTFALWIKAVKSGSSFWGA----CTGLLYFYMVTAWGGYVFITNMIPLHVFVLLLMGRYTSKLYIAYTTYYVIGTLASMQVALGVFGLLQLFAFYNYVKGL-----VSSKQFQILIRFALVCLVGLATVVLFALSSTGVIAPWTGRFYSLWDTNYAKIHIPIIASVSEHQPPTWSSLFFDLQFLIWLLPVGVYFIIIYSV---CGVMVRLVLTLTPCVCIAAAVAISTLLDTYMGPEVEEDKVSEEAASAKSKNKKGIFSILSFFTSGSKNIGIYSLLSRVLVISSTAYFLIMFVYHSSWVTSNAYSSPTVVLSTVIDDFREAYDWLRRNTPYDTKVMSWW........................................ 551
9 -14.400[S] COG4713 Predicted membrane protein  ali follow..  9  115..............................................YSDIVYIPQSIGINL--RASALYMMYFGRIANLICWTIIVFFSVKLIPF-------KKNLMAFLALTPMNLYQAASLSADAMTNSMAFLSIALVLRYAFGEEEAKLTKRQIVTMIIAFTLLAFSKRIYFVMCIL---FFIIPIKKFNSKKDYIGTFVIMLGACLMSLVTVSVISKILAIKVSAGSYTPGQMEFVLSHPITYIHILLRTFHYAISFIGVFGWLDTRLPLNLYLFYGVALVLIALF----------HTLIEKNKDRIIMFIVFIINVGLIMSALYVSWTKAANIIEGGRY---FIPIIPLLGCFIGVKANKSRNVYSKVVLAISTFTILTYSVLQLLLRFYGIRIL................................................................................................................... 456
10 -14.400[MU] KOG2515 Mannosyltransferase  ali follow..  10  17TFSILAVLRLTSADEVYNYWEPLHYLLYGYGLQTWEYSPEYAIRSWFYIALHAVPGFLARGLGLSRLHV-FYFIRGVLACFSAFCETNLILAVARNF-NRAVALHLTSVLFVNSGMWSASTSFLPSSFAMNMVTLALSAQLSPPSTKRTVK--------VVSFITIGAVIGWPFSAALSIPFILLELVDLKGRFRHLFCRWFKAIFVALLITGICITV-IQFVAWNIVKYNVLAKDGRGP-------------IYGTEPWWYYFANLSLQHNIVLWFAMACGPLVLLAA-----------FTNWINLDSFLDLSSVISPFYIWLFIFIIQPH---KEE----RFMYPIYPVLCLAAAIGLDMSLKLMIQILCVYAIIGCLSIARILAIQNYNAPMIIYPAISFLETDNNVTTNVCV................................................................................................... 424
11 -13.900[S] COG5542 Predicted integral membrane protein  ali follow..  10  113................................................SLWPKIISFLAFRSKDV--VLLGIVSCFASIFFHAIACYALYLLTKSIFSNQKMTAYTVIFYCFSPSGIYMSV---GYTLFAAFSFLGLLLFIK-------------KQQYPAAFLWSLATLIRSNGIFWCIFFGMPAIGTLKISLERLQLTFMQVSQLVGYGTKCLIILVPFF-----YNQYLGFKLFCPGVAWCNKSLPLIYPAVQEKYWNVGFLRYWTLNNIPNFLFALLSIIPILFALFY---------------SGSTLHSFRSIKSHLVLSALYLYIGCFHMHTQVLNRMSSALPLLYWSM--AHATLYAKSRNLKAFGHCILFVWIVYTVIQAGLYGSFLPP...................................................................................................................... 425
12 -13.300[MO] KOG1771 GPI-alpha-mannosyltransferase III (GPI10/PIG-B) involved in glycosylphosphatidylinositol anchor biosynthesis  ali follow..  9  5FWLAILVFRWWNAKTFFQPDEFYQSLEVAHHFIFRY-WTSAIRSALHPLIFAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRY-GSKTANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSRKKAYSSLLGFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIF-----------------------------------VLCVSLFLVNIIADRILYGRFVFPIISFFQFNVTSGLYLSQALPLICGGFLPFVLLTMDLQTAGTILCVFFPYSLIGHKEL----RFVYPISPILLTLAGKFFSSFSSWKRAAALVITFLCRFHQFGVMEVMPLIHSLAEKNQTGLILAPCHTTPWQSHIHSPFAE............................................................................................ 419
13 -12.500[G] KOG4123 Putative alpha 1,2 mannosyltransferase  ali follow..  10  23FAAVRLLLVFVPQLGYVHPDEFFQSVEVMTGDHFREFNNSLPVRSIVLPFALLRIPWSWWQLELLGTYAYVVFPRLIYTLISFSNDYCLFRICRLYGLRFEIRLL---AMGSSWILLVFGTRTFSNSLEMAMCSWLLCLVVRIWKLKNSLPAHNLQHLMAMSTICVAGVFNRPTFLLFGAPMVFFWLLRGMGTRSITFRDFNLRIALFCLCALPALVLFIFC--LTLGELHMMHLSIDNFVFTPWNFIKAQTASHGVHPCYVHLMVNMPM--------LFNVLALASLGAFAQLLLRFFRAEYQVLPRFQSIVSLMSGAIFVPLFFLSLINH-------QEPRFLLPVTFPLILLHAPKLITGFSAKYPFVALTLFFGFIHQAGVYPLAAD--------ISHVIATKPAATHVHLITSHIYSLPLHLIN...................................................................................... 515
14 -12.200[S] COG5617 Predicted integral membrane protein  ali follow..  11  66..............................................YPPLSYLTAGVLGKVLGS-----DTKGYAATLMLTSFLGALALHHYLKST---GREPCISPLIFLLFPWHLTYIEGNFPRANAIHLAPLFLLSLYWLREKRERY-------LIASALGISIVALTHYSILPLLIITGILILWDDLRTMTALG------NGIKVLGAVIGLTSFWYVPFLFDKFWNISENKALFKSFSLNPTLLKSPFGILLILLLLIFAIFAIKNLVDRKKVILAGLYLYLS------------------------LGFYSPTTWLYSFPLLSIVP-----------YRWFDLEALIIPLLIGESLKRVQRKSMVALVIIPFTVLAFMNVPKI.............................................................................................................................. 359
15 -11.200[MU] KOG2516 Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family)  ali follow..  9  87................................................PTSIDVQLVVRGIVGLTNGLSFIYLKNCLQDMFDEITEKKKEENEKDIYIYDSAGTWFLLFLIGSFHLMFYSTRTLPNFVMTLPLTNVALGWVLLGRYNA-----------AIFLSALVAIVFRLEVSALSAGIALFSVI-----FKKISLFDAIKFGIFGLGLGSAISITVCLPEVDGFLFNVVAGYASKWGVEP---------------VTAYFTHYLRMMFMPPTVLLLNYFGY---------------------KLAPAKLKIVSLASLFHIIVLSFQPH---KEW----RFIIYAVPSIMLLGATGAAHLWENMKVPLSIMTSFFISMAFLYISRMNYPGGEALTSFNDMIVEKNITNATV-----HISIPPCMTGVTLFGELNYGVYGINYDKTENTTLLQEMWPSFDFLITHEPTASQ.......................................... 468
16 -11.000[S] COG4485 Predicted membrane protein  ali follow..  7  83..................................................YYLGLAPLVYFFDLTNMPDAIYLTTLLKFGLIGLST-FFSLNKLFQSIPQILKLALSTSYALMSFTVSQLEIK-TWLDVFILIPLIITGLHLLITEKKL---------LLYFTSLSILFIQNYYFGYMTVL-FLIFWYLCQISWDFKTRKSSVLDFIVISFLAGMASLIMTLPTLFDLQTHGEKLTEV------TKFQTESSWYLDLFAKQFIGSFDTTKYGAIPMIFVGLFPFILTILFFTLKSIKFHVKLIY-------VIFFAFLIASFYIEALDLFWQGMHTPNMFLHRYAWIFSTLLIYTAAEVLKRLKELKVWNFLVSLFLVVAGFLATI................................................................................................................................. 395
17 -10.300[S] COG5427 Uncharacterized membrane protein  ali follow..  13  100AFVFLIVVRAWADGQPAGGEQFLDF----------GLLQALDRAGQLPP-YYYGGQLMASIGAHLTDTAPRFAYEPALAGVYAMGCTAAYGLASTIAAGNGAGVLGAFAFGFAPLFAYLNGDLHAHMVSVPVLFVAVAVGVAYYRTPARRRRRWALLWGGFPVAGAAILTVNTWSLPTVFGVAALAVALADPAPATLLPVQRVLLAVGVAAVGGVLAVVIAWPFVQNVLLAGASNQHLAVLPVPSQAGALVFVHGLFLAAFGAYFVAGAAVAVAVAVGPVVGGVGITAVVLVGPVLGAAWWLRRRNAAGVECVLVAAGAGLVVLVEYVYL-----ADAASYERFNFKVYAQVWALWSVAVSERRASTGGLGAVFVVGLVVAASVYLDALEYAGNAHPGAAARWLGDRRRGTRIVAAPYTWQNPAASLSGAGWAWEQRVDDIGVVY----ETTDAASRAAILEK-------DVTYVWVGPVERARYEIPDLSADPGIEPVHRTPAVTIYRVTDDE. 783
18 -10.200[S] KOG4587 Predicted membrane protein  ali follow..  11  119.VILAFLYRPFRAFAKSANWQIELCWQVNR----GELRPVESCEGIGNPHYFYITGVF---------------------IVAGTVASSIFYLGVLVSDSIFGGFLSVLCFAFNHTRVQWTPPLREFAFPFII--GHIAILTFVIKYKKSGHS----MILLLTSMAVPALLFWQFTQFAFFTQICSIFLAFSLDLIPFSTAKTVIHSHIISFLIGFLLLFGNEMMITALYFPSILALGMIIYISPLLSNLKFRPAYVLFLAIIFASITLGLDDAHIFDILRSKFTSFANFHTRLYTCSAEFDFIQYSTIEKLCGTLLIPLALISLVTFVFILYNVVQLCCSTVRLKLFMTPHLCIVAALFANSKLLGGDRISKTIRVSALVGVIAILFYRGIPNIRQQLNVKGEYSNPDQEMLFIQHNTKQDAVFAGTMPVMANVKLTTLRPHPHY-----------------EHVGIRERTLKVYSMFSKKPIAEVHKIM-----KEMGVNYFVFQLMNCSNDER 626
19 -10.100[S] COG3463 Predicted membrane protein  ali follow..  9  83................................................PVYAIM--------------PSPVVLLLIQAIFLALSATLALLIACEELNHREAILVASLYIFNSSLLGIALFEFHPVSLAVPLFFIAYMLLKR-------------GKMKLFYLTSVLILLTKEDSFLGVVSLSLWKILMDGLNPESFRK-----------NRGLILLSIASMMYGIIVIKVVIPHLGMG--------YIYESLYSEFELTRRKLLYFIVFNASFGFLTFLSSKGLVSVALPWLESMLSSRDTQT----------------------------------MIGFHYPYMLLPLSYLVAIEGFKKSKKVAVSLIVAGILTSMATIPITFK---KPIPGKDASWEAITIVKTLEGPIYTQPE-----FYPHLSTRIDVYVYPKGIKPRVILVNLNT............................................................... 412
20 -9.830[R] KOG2647 Predicted Dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  9  17LIKYAIFSRLLVLFLTILWRSLLQPYDTSAANAASRSLENSVVWDS--PLLPFFISLLSRTVFAGLRAVMVLSGFTVSNLAFIFAAIYLFRVSVIILKDTEASFRASIIFCFNPASIFYSS---IYSLYALFSIGGVYHLLS-------------GTSNVGVLWFALSGCARSNGILNAGYICFQTMHRAYEALYQKRRAYLAMQVFIAGFLRCICICLPFVAFQAYGYYNITRDEVRPWCKGRIPLLYNFIQKILVSDRGVGFLKYFQFKQLPNFLLASPILSLAVCSIMKPSSKKDVTGTKVAPEKSGYLSADVFPFIVHLSFMVTTAFFIMHVQVAT--RF-LSASPPLYWFASSLIGSPKHSKWGYLIWSYCAALLGTLLFSNFYPF............................................................................................................................ 491
21 -9.800[O] KOG0828 Predicted E3 ubiquitin ligase  ali follow..  10  369...............................................................................................LLYSPDCGVRLGLHNVKGTRYELKIMSIRKHLLFGIALFAAQIYLLHHTNTPSMVNKISFYCFSMINLVDGSLATLYFVAASVVPELYLPLVISA--------------------FSCFILASIFEIRYLISIYASQVNEQNVGIINLLRGNTSLYGRFFFMLIIFTFLILSSTSWPRQLRMVFEYILIFILNSYWIPQIFRNAVK---GIPSRRERARSSIGGNRSQNKMPLLWSFVIGTTIIR------SLPVVYVFTYSSNVFRHHKDVHFVVFLSLWLLFQISILYSQDVLGSRWFLPKHTIPDGYSYFKPLSNEYISEHGGGTAEHTVDCAICMSD-----------VPIYIEEIPETHKVDQHSYMVTP-LENWM--------NYKLQCPV-----------------CRSP.. 754
FFAS is supported by the NIH grant R01-GM087218-01
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Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.