| | | | | | . 10 . 20 . 30 . 40 . 50 . 60 . 70 . 80 . 90 . 100 . 110 . 120 . 130 . 140 . 150 . 160 . 170 . 180 . 190 . 200 . 210 . 220 . 230 . 240 . 250 . 260 . 270 . 280 . 290 . 300 . 310 . 320 . 330 . 340 . 350 . 360 . 370 . 380 . 390 . 400 . 410 . 420 . 430 . 440 . 450 . 460 . 470 . 480 . 490 . 500 . 510 . 520 . 530 . 540 . 550 . 560 . 570 . 580 . 590 . 600 . 610 . 620 . 630 . 640 . 650 . 660 . 670 . 680 . 690 . 700 . 710 . 720 . 730 . 740 . 750 . 760 . 770 . 780 . 790 . 800 . 810 . 820 . 830 . 840 . 850 . 860 . 870 . 880 . 890 . 900 . 910 . 920 . 930 . 940 . 950 . 960 . 970 . 980 . 990 . 1000 . 1010 . 1020 . 1030 . 1040 . 1050 . 1060 . 1070 . 1080 . 1090 . 1100 . 1110 . 1120 . 1130 . 1140 . 1150 . 1160 . 1170 . 1180 . 1190 . 1200 . 1210 . 1220 . 1230 . 1240 . 1250 . 1260 . 1270 . 1280 . 1290 . 1300 . 1310 . 1320 . 1330 . 1340 . 1350 . 1360 . 1370 . 1380 . 1390 . 1400 . 1410 . 1420 . 1430 . 1440 . 1450 . 1460 . 1470 . 1480 . 1490 . 1500 . 1510 . 1520 . 1530 . 1540 . 1550 . 1560 . 1570 . 1580 . 1590 . 1600 . 1610 . 1620 . 1630 . 1640 . 1650 . 1660 . 1670 . 1680 . 1690 . 1700 . 1710 . 1720 . 1730 . 1740 . 1750 . 1760 . 1770 . 1780 . 1790 . 1800 . 1810 . 1820 |
| # |
Score |
Template |
Links and tools | %id | First |
MQDASEPVINMPALPMNSVNEQHDRHEDLPEVGTTSVTKIINDSDNEDDENGMDLGRVASESLEGDAVVSIDINTEDSSLSPAKQENEKSPEGIEQKYQEEDLKDDKKSNETIATPVPDAASRASLEKQKSGLTNLEKSTHVVLIKCIEQLIQIKVCMKNEKMKNLMEQLKPLLQTECQFDKFLIVELFQYCFESSQDEVMNISLDTISKLASFAYFSSKDKTPASFGPPKSLLQCMVDMVCDSINDEVVDGNLQLNVVKALSAFILCSEQDSMLHGAILLNSVRKLFNVFLLGDSDTIQSVAQASLTQAVTVVYERLRASHTQSNSTSALPEEDASVTENWVHDEDEPDKKITLHSMASAGTSSLDHVKVDADDPAVTSVENSSIQDAFLVFRSMCRLAVRQTSPDKVSNIRSQAMRAKLISLHLIYRILEKNSDLFMDPTLQFRGIPALKGMTLVHASRQYICLVLSRNAVSPVPQVFEVCCDIFYLMVFSLRAHFKQEIEVFFREVYFPMLDLKNTSYNQKLHTLLIIQRICLNPRALVELYINYDCDRSSTTNVFEQLLFSISKVTTNGPSETISEDIEEILPSLESSERSSTPFLNTNSASLKSEVVQLTTFSDFQLKLKTLQCVLDILQSLSNWAESGLYLSRRGVSTDEQGFVGDYDALSRSDTPVTNPYYNGKQSFEANSHSSSSIALADPSQFESNKQRKKLLRTCINKFNYKPTRGLKMLSENEYVDINDPKAIAEFLFRADGIDKTTLGDYLGEGDEKSISVMHEFIDCLSFINLKFVDALRRLLQCFRLPGEAQKIDRIMLKFSERYMKENPSAFANADTAYILAYSIILLNTDLHSPRIKNKMTKEDFIKNNRGINDGADLDEDYLGFVYDDILKNEIAMKDDQELAAIAPLMNNFSTSSGFTTFTSNGRDLQRVACIQASEEMANKATSVLKKLLYQQKHGSQKTNVYYNATHFEHIGPMLEATWMPILAALSNPLQNSDYVNELNMCLDGFQLVVRIACLFDLDLIRDAFIKTLTNFTNLHSTSEIKLRNTMVIKTLLRIASTEGNNLKDSWKDILTIISQLERVQLIGVGVDETEVPDVINARVRRKNVNIGSSNSIRHVSGSTSRSTRTRSLSKPLSPEAVSELMSTEVVLSIDRIFTQTSSLSGSAIVSFFKALCEVSWDEITSSSDLEQPRLYSLQKLVEISYYNMQRIRVEWSSIWNVLGRFFNMVGSDENRHVAVFALDSLRQLSMHFLEIEELSLFSFQKEFLKPFEYVMASDTVVEVKELVLQCVKQMIQAKISKIKSGWKTLFGVFTFAAKARSEILISMTFDTLVNLFSEHYDTLMQQNCLIDMLISFTELCKNGTNQKISLQSLEIIREVYSSLSTMIKEGLSSKPSVNETFSKYVFPVLFAYYDIIMSAEDLEVRSRALQNLFYIFLEESDDFTEETWEVVSRKFIFPIFSIFGPEADEATVMLRDEEIRTWQSTTLVEALRSLVTLLTRRFDKLHNLLKGYLWLFSNCICRDNITLSRIGTNCMQQLLSGNAYRFEVKDWNLVADMFIELFKETTPHQLLLLETFSNGQGAPVYSENENTQLSHKRGGSLPETSRSISTSSISPEKQMEFRSMIRKCILQLLLISIVAELLDNEEVFNHIPHEHVLKITVAIYDSWQFARKFNEDKSLRITLLNVGFMKQLPNLLRQETASALLYITLLFRLLKTRDPLGKTETDQKIHKLLFPVCAEMLDMYASLVVEKHTRNHAAWQPVIATILDSILNLPLELFSENIHTLYFSCCSMIAKENLDDQLRELLKNYFNRVGHILLNLNAQQE | Last |
| 1 | -321.000 | [R] COG5307 SEC7 domain proteins |
ali |
100 | 1 | MQDASEPVINMPALPMNSVNEQHDRHEDLPEVGTTSVTKIINDSDNEDDENGMDLGRVASESLEGDAVVSIDINTEDSSLSPAKQENEKSPEGIEQKYQEEDLKDDKKSNETIATPVPDAASRASLEKQKSGLTNLEKSTHVVLIKCIEQLIQIKVCMKNEKMKNLMEQLKPLLQTECQFDKFLIVELFQYCFESSQDEVMNISLDTISKLASFAYFSSKDKTPASFGPPKSLLQCMVDMVCDSINDEVVDGNLQLNVVKALSAFILCSEQDSMLHGAILLNSVRKLFNVFLLGDSDTIQSVAQASLTQAVTVVYERLRASHTQSNSTSALPEEDASVTENWVHDEDEPDKKITLHSMASAGTSSLDHVKVDADDPAVTSVENSSIQDAFLVFRSMCRLAVRQTSPDKVSNIRSQAMRAKLISLHLIYRILEKNSDLFMDPTLQFRGIPALKGMTLVHASRQYICLVLSRNAVSPVPQVFEVCCDIFYLMVFSLRAHFKQEIEVFFREVYFPMLDLKNTSYNQKLHTLLIIQRICLNPRALVELYINYDCDRSSTTNVFEQLLFSISKVTTNGPSETISEDIEEILPSLESSERSSTPFLNTNSASLKSEVVQLTTFSDFQLKLKTLQCVLDILQSLSNWAESGLYLSRRGVSTDEQGFVGDYDALSRSDTPVTNPYYNGKQSFEANSHSSSSIALADPSQFESNKQRKKLLRTCINKFNYKPTRGLKMLSENEYVDINDPKAIAEFLFRADGIDKTTLGDYLGEGDEKSISVMHEFIDCLSFINLKFVDALRRLLQCFRLPGEAQKIDRIMLKFSERYMKENPSAFANADTAYILAYSIILLNTDLHSPRIKNKMTKEDFIKNNRGINDGADLDEDYLGFVYDDILKNEIAMKDDQELAAIAPLMNNFSTSSGFTTFTSNGRDLQRVACIQASEEMANKATSVLKKLLYQQKHGSQKTNVYYNATHFEHIGPMLEATWMPILAALSNPLQNSDYVNELNMCLDGFQLVVRIACLFDLDLIRDAFIKTLTNFTNLHSTSEIKLRNTMVIKTLLRIASTEGNNLKDSWKDILTIISQLERVQLIGVGVDETEVPDVINARVRRKNVNIGSSNSIRHVSGSTSRSTRTRSLSKPLSPEAVSELMSTEVVLSIDRIFTQTSSLSGSAIVSFFKALCEVSWDEITSSSDLEQPRLYSLQKLVEISYYNMQRIRVEWSSIWNVLGRFFNMVGSDENRHVAVFALDSLRQLSMHFLEIEELSLFSFQKEFLKPFEYVMASDTVVEVKELVLQCVKQMIQAKISKIKSGWKTLFGVFTFAAKARSEILISMTFDTLVNLFSEHYDTLMQQNCLIDMLISFTELCKNGTNQKISLQSLEIIREVYSSLSTMIKEGLSSKPSVNETFSKYVFPVLFAYYDIIMSAEDLEVRSRALQNLFYIFLEESDDFTEETWEVVSRKFIFPIFSIFGPEADEATVMLRDEEIRTWQSTTLVEALRSLVTLLTRRFDKLHNLLKGYLWLFSNCICRDNITLSRIGTNCMQQLLSGNAYRFEVKDWNLVADMFIELFKETTPHQLLLLETFSNGQGAPVYSENENTQLSHKRGGSLPETSRSISTSSISPEKQMEFRSMIRKCILQLLLISIVAELLDNEEVFNHIPHEHVLKITVAIYDSWQFARKFNEDKSLRITLLNVGFMKQLPNLLRQETASALLYITLLFRLLKTRDPLGKTETDQKIHKLLFPVCAEMLDMYASLVVEKHTRNHAAWQPVIATILDSILNLPLELFSENIHTLYFSCCSMIAKENLDDQLRELLKNYFNRVGHILLNLNAQQE |
1822 |
| 2 | -93.600 | [U] KOG0931 Predicted guanine nucleotide exchange factor, contains Sec7 domain |
ali follow.. |
17 | 2 | ..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAFRDVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRG-AEAEALEQLSSSSTSTKSAKSGSEA----------------------------------------SASASKDALQAMILSLPRYHCE-------------------------------------------------NPASCKSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIP-DTPIGVAHFLLQRKGLSRQMIGEFLGNSKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVFHNPDTIFILAFAIILLNTDMYSPNIKRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSLVCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKTFCKSVGLLGMQFQLFENEYYSHGITLVTPLSGSEKKQVLHFCALGSDEMQKIAEVTELEQIRIEWELEKQQGTKTLSFKPCGAQGDPQSKQGSPTAKREAALRERPAESEVSIHNRLQTSQHNSGLGAERGAPVPPPDLQPSPPRQQTPPLPPP----------------PPTPPGTLVQCQQIVKVIVLDKCLARMEPLLSQALSCYTSSSSDSCGSTPLGGPGSPVK......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
661 |
| 3 | -79.900 | [U] KOG0932 Guanine nucleotide exchange factor EFA6 |
ali follow.. |
11 | 2 | .......................................................................................................................................................................................................................................................................................................AKVASSGAEEALATIDGAPRRNVKKSEKLLGDQLPPGTTVASSIHPHQLSRATASAGVSFPSMNRNGAAAQKLSRLPVPVSTSQIERRGSLARKTSEESSPTAIRMLKTAPIERMESTDVEESEEETVMMTTDE--------------KENQKKPNENDDEVMVVDEEQFIVVSNDMKSPNEEIVAKSLRSAMFTMPTDNHHHSYNSSPQIS-------------------TLSPHLRSNGDGPSRSPVYDDVDDDLNG-SLDAKDMSNNSHQQSFRSPE----------------------------------NYSEKDTPSKHSVVTIDGSGVSNHYDQDGMFSHVYYSTQDTTPKHGSPSLRKQIFESRTTP--------------NTAASNSSASASPSLHATSESRGATGGVSLRSAESSNLNQTAVPSTSTNSVGGEREAAQIARNLYELKNCTSTQVADRLNEQNEFSFLILVKYLELFQFSTTRIDAALREFLSRVELRGESSARERLLRVFSARYLECNPAIFDSLDEVHTLTCALLLLNSDLHGPNMGKKMTARDFITN--IAHTGCTFKREMLKTLFQSIKDNAISLQNSAKNSTANGSVASTSRRQPQQIYEVDPDSVVEYYSGFLMRKYVRETD----------------------GGKTPFGRRSWRMVYARLRGLVLYFDTDEHPKASRYASLENAVSLHHALAEPAPDYKKKSFVFRV----------------RIAHGGEILFQTSNQKEL-QEWCEKINFVAAAFSSPTLPLPVTSKPETRIPCLAPITKQLSTHEARVAELNEMIEIVSQSVSPNQPQQLITDRWVLLSFEKR----STYINVLRRSLEARKASSATTMNIMMTPTRRQQQNQKPVV....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
801 |
| 4 | -71.500 | [U] KOG0930 Guanine nucleotide exchange factor Cytohesin, contains PH and Sec7 domains |
ali follow.. |
26 | 14 | ...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQ-SSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLT--------------------------------HTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREV-EDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISA-EEKEEWMKSIKASISRDP............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. |
383 |
| 5 | -17.800 | [TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family |
ali follow.. |
7 | 515 | ...........................................................................................................................NSFCLLFDERSLFKIPYHELFCALLKNPDIISSSVKQSLLLDGFFRWSQHCSNFNKESMLSLREFIMKALASTSRCLRVVAAKVLPIFIKGPNNLDIVEFHKEAVENTAILETVILSWIS--LSRVVEEEELHFVLLEVISSVINSGIFYQISVWQLLSIASLFAQLMNISEGDFLIRTQAYTLPFLVKALIVRIAELSQSDVATLCLTNMHKILASLLTTDHPNLEESVMLLLSLATSDFEKVDLTSLLRSDPISITVELLQEKIENALRKVAMIVSQVVNDEDLSNKELLYDFFNNHILGILAEFSNILNDLKGKTSINEKIKTIVGIEKMLSLCGGAVKLGLPQILSNQNEHLRFYAIKAWFSLILATKEP---EYSSIAGLSLVILPP-PYLEPQEAELVIQIFDFISSDTHKCLQGLKW---------------IPTSLDSACFSLKAKEIFCSLQNEDFYSELQSIIKCLTNENEP----------------VCYLGLQKLELFFQAKVDELHDTL---------------------------------------------NLDISNEVLDQL-------RCLLDCCVKYASTNMQ-ISYLAAKGELGAIDPSRALKFILD---MQSQLIPAFLVTTDTKAQGALQEFLKLGGFKSASLPDLSKRVLIPFRYP--LKLMEYAHSQNAEKIFGICSKVVKDQEPCFLLPFLVILTESELEVNKVIEEFQL-NQPGPDGLNSVGQQRYTSFVDVFFKIVRKKRNWDRRSAIARKENRYMSVEDATSRESSISKVESFLSRFPSKTLGIVSLNCGFHARALFYWEQHIRNATAPYAALESDYRVLQEIYAGIDDP-IEAVSLNFHDYSDQQLLLHENSGTWDSALSCYEIIIQKDPENLLNSMLQSSLVLSLDSFIINDNHEYSKMLNLG------IEASW--------RSLSIDSLKKCLSKSNLESFEAKLGSIFYQYLRKDSFAELTERLQPLYVDAATAIANTGAHSAYDCYDILSKLHAINDFSRIAETDGIVSDNLDIVL---RRLSQVAPYGKFKHQILSTHLVGYEKFENTKKTAEIY----------LEIARISRKNGQFQRAFNAILKAMDLTIEHAQWWWHQGQHRKAISELNFSLNNNMFDLVDEHEERPKNRKETLGNPLKGKVFLKLTKWLGKAGQLGLKDLETYYHKAVEIYSECENTHYYLGHHRVLMYEEEQKLPVNEQSERFLSG-ELVTRIINEFGRSLYYGTNHIYESMPKLLTLWLDFGAEELRLSKDDGEKYFRKKSLELMNSNVCRLSMKIPQYFFLVALSQMISRVCHP---------------------NKVYKILEHIIANVVASY----ETLW-----QLMATIKSTSQKRSLRGKSILNVLHSRKLSMSSKVDIKALSQSAILITEKLIN.................................................................................................................................................................................................................................................................. |
1988 |
| 6 | -15.800 | [O] COG5021 Ubiquitin-protein ligase |
ali follow.. |
9 | 4 | .......................................................................................................................................................FTRCEKARKEKLAAGYKPLVDYLIDCDTPTFLERIEAIQE--DRSRDDL----IPILDRM---GLLLKVAEKYKYKQDPKKECEVKLVEM------EAHDVDYCLKMLKFTRRLLLN------TENRFVYSSGDVLMYLLNCPNFTIKLAVMR-----ILAILGERFVIAREKIVAHNIFGDHNLRKKTLKLALSLSSSVMDEDGEHFSLVDLYFDKKKVPQKWRK-------------------LRFTHYTSNDFKKSSQQKNNINETQTSIKKVTMTTQELCEHSLQQIFDKGMALLPAESWFDFSIKASVAKAFSDDSGENETKLNAIAFVNTIFSPPQVSSKLFELDPYAFNSLTDLILSETKIPKELRTDALFTLECISLKHVWCSDIILGGNISHGLLFQILRYIAKTLREAT-------------------DEIDEEYNVRFFYLISNLADVKPLHESLFAAGL----IPTLLEIVSPYKRTLASATHLLETFIDNSETTTEFIENDGFTMLITSVANEIDFTLAHPETWQPPKYSVVYYSISFRELAYIRSLLKLVLKLLSTDSGDRIRNLIDSPILVS-----LKKILENKLVFGLTLVQKVI-NSEPTIYPVLVYVIDNFP-PSAELLSLLPDVVSAICLEGEKGLINNLFDFLLDDHAR----ILTGGDRSTEYGTDIDEL---RHYPDLKANI----------------------VEALCNVI--RKMPSTFRNEREFLFTSPKDQKYFFHRKNEEILTDKEEHEPAYWELLDKGTMLDTFTS-VLFGMSLGNGSFSQVPQHLEARDFLAIIFMENPPYVTEVLQYLDEKYEDYAFMDVMKVLNDQLENLNDFLNSPNDRSFFLERDGENSVRSCH----SKLCRLAAILNIVTN--SYFDKRGFSLIKNLKLLFQKCALEEMYIRQHMPDSVITETMPLPIVDVSGDGPPLQIYIDDPKKGDQKGKITSVKTRNTLQMRTILY-NTAILFRCFLRLDLTTEVHIFENVVENVIEMLKATELEGHLPYILLQTIPAYIFYQKGGYLLYLHIIRDLFTRMTKNYIDESNGILTLSCLINALTFYNKSMQTETMENVQSIGKYYVS-DYNIMKALTVPIKVMALAMILDLDKSDSLFKTQSRNVPYSVFKQLLSELHWDLIFPPIKKISLFEQVGIPGDVAANYLTDTSKELDELRDTFFNDGLPSRIFTVLPFYPKLVNAFAKTLLQIFTKYDEPTEVFAGRILDRILETDLDDPATYIYQKASHLMQRFIEYLEKSLKPEHVNTPWFSKALYVYEIILAKSELPHLEELSKDVLL--FYSALATSRILIFYSRDE-GILSRLLESSFLLLTRRCFETTENVDALIRAEINRSFTARPLGGGDDAVRELTTILEEKAHVVMPSQFIDVLCETARFHEFDDQGALVDYSLKRFLGEKDKNTQASSTEKSDIYERTGIMHLLLSQLMAASEKDWLSEPANSSDLPENKKAQLLLKLLVELVSSYTFSRRNTYAERPRPRTTAINFF--LYRLLKRREVIGMLARSVIIGFLATVQDDRTTKTDVKIRKFAIEAIIKAIRNATSSSKLLESNKLDMWFRIITSMVYVQYQLCKLVIDLG---LPSVITEAMASIDLNPFSKKIFNVAVEALNTI......... |
1864 |
| 7 | -14.800 | [S] COG5543 Uncharacterized conserved protein |
ali follow.. |
8 | 12 | ..................................................................................................................................................DLESLPSQPTVSSFQQLRETFIQSKSEDWYLKNGLFFRYYSFLKSSLENATGPSQVACLDTISVWLR----DPEISKYVWDTMELKFWTNLFSLPANKISIPGLTGVAVKDVFSKSLQLYLLVCPSEDIKNDFLLDSLKHALHWDRHAKVVLVKVTGAEAVFAFQPDFFEQSLKLLKDYSYAQAISSTILTVLTLRFKSLSEETEDREEVETK---CPIILYEFYGNDRQVQAGMSSFLIPSLLGVSPGITVKFLSRLQNYPNVSKDAIKNLDLVKEHAFVKTLFKHPDIKIQLACFRLIALCPNVSSPLSFEDFDCLESNIEFSFNVLDPDSRQILLKSMQDFFIRLRASCHSRAMQFLTSFISVCKKHPTCNYQQVLVSLSFLDTLISDRDLSRLM-------IDRLKDPYDDIRNLCLKILLSYKSLPGFISDSDAYFLFNHGLELLNAVRSHECDGGAKTIYLCNHFMEKSVPGSVLANTKVILNRLKS----------------------------------------------------------------NIEHAKTSLLEAAV---NCPLQGYLIQLTY-IFQSLSPTIVKNDNESWKNIVMELI-KASETIWGLIKDVLCD-EGEGGIVSNLEDTPAQLILSSWRSLKETSSL---LTVLLTKCLSLFDEEFTPFTLNYYGELMMTWLWEIRHRGAFTS--VYPCFIEYCSFLFECNKLPDPWLHKNLSVIQEKSSFITRRSGG-----------IPLSITAILVAGKDKREQLIEQTVISLISIAKQ------PVEQKNIAGQFDLPQVHAMNTLKTIFT-------HRLSSVSVEY--EPAIALSIEGFSHPIRNCSVM----LFTALINRAFGSKKPKDAVNLGNNKGLSTKMFFS-----------KFPTLHDYL-----LRELEVSVASLSSNDQPSTGL-----------------NMFSRLQYAQPYGNENEWTGLSQFEPLIFKCTASRIC-KVREIASLSLTCLLTFIVSQLKGVAGLQQNEIHGKLLTIRAVLSFSKLTLQQVQEFYEVVPLAFINCFLEFTSSKTSFYAKKLFLEVLNSYFMSNTDSNAKRLQQLRRMTMDYCKRMLLDRKANVTNVFNTIGLPIHQQMAATIYCDAHSIGFLVSKLLHYEFYEVQLTTLRSIVDSPRK-----KIIVNNPEILQALIKLTPRNQWSQVRALALSLLSDSLNSTSYRLLGI-----------------SCSDMVSNILSNECLPIKESFIVLLGSCIKQLKTENFLEY-----KVTFAKWVEILLS---------SNEYQPFSSRKAALDSIIHFDLFNAE--EAFSFEFYILYLLLGDFLNDDDEEIRSLAANHAYQVL----------------------------------------------------------------------------------TSAQCVTEIWNLWKLRTKATFGGQHDFQHCINKRLILEDGCELASVQLDNALSRNCSL--------FERERQNLYYSDNQKLEDLLFYASYPN----------------EKLKDWATDGINAILSRFEDVSRDGPLGKTSHVHLPLDRVHSLMNRI------DGHPSFCQ.................................. |
1502 |
| 8 | -14.500 | [DK] COG5103 Cell division control protein, negative regulator of transcription |
ali follow.. |
9 | 2 | ......................................................................................................KSQEQQTPETREKSSSTSESGHPISLDSKTPPPNDSKIESIVKAQILFLLSTLREDQYDTKLEQIRQLINKNAPRVYH---HFLRRLIQGNSYRIFGTGKSSDGLATYKLLLDELKSLTKSWVMAKRFSDAISGSDSEVFEDFDIEAFLDHFQFSPLRTNLLIGLTTSVKPTLAKKALKNTFQSLLNQLSDPTQSIDKNDLDLLREGLFTTDYDRIPLIKVPKFDAIIEKKLANSRPLTALFGPMKASKATLKSMKEAILKKYPPGTATETDVAYLINSLVAIHDYGAWDTVLMGKAIVSSFEN-DNPKFMITGTPSLVLFFTIFTNAYKLRQTNFTLDFLWVLWRNPLPQLSIISHIILELVQILLRLLSEVVTFLNFLDEELLLLGTLQLPLAWNPVQESLAFQWCSDFFSNFKEHKTNPQFLFAFLRSLWLKDSSSVNQVVEFIIENDFTSHIGNEIAALAAARKALSFQDWLDKKMLEFEDADGLNVFLVEVLDFLMSRAALQKNESEQKEESVVLSIDTVNVLLTTLMDNVSISEEVSEHIKDVQILCLQVYPRLFSLGHDRDSIVIATNTTNSFSPDVESEVES-------QALYERRISIGKIVLTLQNFKKSENP-QHSLFDE------------RFFPDYPLEALALTAVLFGS-------IQFELL-----SFVPLGVALRYVYQALLMPTDSK----------------------------MFRFGMQALV------QFQEKLPKINYCNLILGIPSLQLVRPDIYDSIREMIASNENTEVEKDKLDSFSALANPASPKAPEYTFVSVCDNILFAINNLSQLNFNEKLKDVKDNLTQRVSREANFLSLYGKFLEELKSSDLYKIVFRDTLQAILDIMNLSPSEKTNLKNLGSWLGSITLL-----------ITTLQVSFKDLLLEGIDSGRIDRVLPFVCKVLESSSVIFKNPWMGILKLLVELYQFADFRLNLKFEIELLLNNLNVKMDNIEPSEMYRNHLVQKADLEKELPEDVLNAEFPDGTDVITQYIVAASSQITVTDAVAQVQQSVLEIISAVVRRSVGIAAITTKSLLQKDFAAES-------NPSRLLLAARQMAKTLAGNLAMVTCRE---LQMLMINNFRTIALQDVENVHAAVAQAIDELVSQNLFVASSVIESVASETAIAEIDAEIEHMIVERVRHRK---VLKLSSELTPQQFQLYENFDRLSLSTIMSNNSFTSLNGLRTDSADSTDALNSNLNNTVENEANQTALNYARNLLIIIGQLFQLAAQMPYTSMQ--HELVNQFLTGVASINHPIADHVFLLCAQECCRILLTDSKSPFILEVFSAILEYICQTKTAINVSLYWNFSNDLEKLNLPIILSLIRFGILTS-----GEVDYHVARGVR------EQGSGPVTDFAIELLRTAVGGENPMALPGNFVNSITSLYEISESFSGETKQAYEQLVETMNKSVSPASEILSDLDNKQQLNDQIIIVFVSWVHLLRNSATNDETKAAFVYQLQFFRCNLEAVLVAFLEAASVNAPDYFNVDAYASLLVNVVKYTEGSTEGTVSSKSVLFRKIIALIMAEFVHQKTFFRLFSSILSE------DDAKDVLESCFVDIYSVILECFLAIQPRSFPAFTFAWLSLI-YLLPKVLLVNNDK-----DLFSEILMSFLKLDLKDDIDKAQFKLLYNGFLRIILVL..... |
1821 |
| 9 | -13.000 | [A] COG5181 U2 snRNP spliceosome subunit |
ali follow.. |
8 | 2 | ......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................STVEDVEIERLRAERELLRRQKEAAKNSSTNG-------------SVNIEGTQDSNDLQYNAHLFKEYIDVRNDIS--------DEDDYKRTNDVNDSYRLVRQYEAP------KELLNEYADE----SYDPMQERQSKKQIQ------ESDYQKQRYDRQLTVDAFQPDGTQSNGRS----------YAEVMRQVELEKEERRVHMELNQRRREGTLKEVEEEESISDKKRELELNNTQKPKRSRWDQAPPSVTQVSTTKRRSRWDKAPENFTISEHVIENGISEDLINKEVNVVEEKLRPPVRLLTEEELNELLPIPGVGDLAFFKQEDVKYFGKLLKVEDEAKLTIAELRKILRLLLKVKNGTPPMRKSALRQLTDQAR-QILPLLMERTLEDQERHLLVKVIDRILYKLDDLVRPFTHKILVVIEPLLIDEDYYARAEGREIISNLAKASGLAHMIATMRPASALGVPALLPFLKAVCRSK-----KSWQARHTGVRIIQQIALLLGCSILPHLKNLVDCIGHGLED----EQQKVRIMTALSLSALAEAATPYGIEAFDSVLKPLWSGV-----QRHRGKSLAAFLKATGFIIPLMEPEYAS--RRIMKILLREFNSPDEEMKKIVLKVVSQCASTDGVT--PEYLRTDVLPEFFHCFWSR-RMASDRRSYKQVVETTVVLAQQVGSRQ----------------IVERVVNNF-KDESEPYRKMTAETVDKVIGSLGVSEIDERLEELLLDGVLFAFQE---------------------SVEEKVILTCFSTVVNALGTRCKPYLPQIVSTILYRLNNKSANVREQAADLVSSITIVLKACGEEALMRKLGVVLYEYLGEEYPEVLGSILGAIKAIVSVVGMSSMQPPIRDLLPRLTPILRNRHEK-------------------VQENTIDLVGKIA--DRGSEYVSAREWMRICFELIDMLK-----AHKKSIRRAA-----VNTFGYIS--KAIGPQDVLATLLNNLKVQERQNRVCTTVAIAIVAETC-FTVVPALMADYRTPEMNVQNG----VLKSLAFMFEYIGEQARDYVYAITPLLADAL--MDRDAVHRQTAASVIKHLSLGC........ |
1083 |
| 10 | -12.900 | [K] COG5221 Dopey and related predicted leucine zipper transcription factors |
ali follow.. |
9 | 2 | .............................................................................................................................................................................................................................................................................................................................................................................SLPLKPLTIDSNNKQLDSKQKKFRANVERALERF-------------DSVTEWADYIALGTLLKALQSWSPKFQNVRYYVPSPY---------QVSRRLTSSLSPALPAG---VHQKTLEVYTYIFEHILETLATECNIWIPGILPLM---TYASMSVRSHLIELYDNYI--RPLISSLLPGID---DESNDFLPLTLKLIETLQENLDDDS--------------------------------QTLFLVMTANKGRRLGGLTWLTRKFPSLNAVPHLVNKIKMEAEENPSETETNDSHLDRKKRKEEAFKVLLPAAKDLVTPERCLVGCLEDENDILIKRSVLDLLLQRLRLDSPVLNVLITSEDKKLLIMS----CCRTTLSKDMSLNRRIWNWLLGPTAGGMFRISMAVMDRWEIGSLVIPELFIPLLYSSEKFKQNEQIMKTARTF-----------FDNTETNIIWGKLFQELED-------IKNLKILDFVLTNFNIGNDEEIIVRHLNKLLNYIPERALLPLSHSKLKHDDEVSCEELLAKIRGFYTNVSNPSSILEKENIAERLPPFTTEDLTFLIADLIQKKLLSSLWDLENINESSKLFIAIF--EKIPESEELKGRSHISWSDKKITQSIFEAIPRLCESNNDAKSEEIVGIVEIFGNYLYSRMEFIESMKLLKVVMMAV----------WKSLVKNLKTLNRFSALVYTFVEEEDISERLSVLDL---TQLDSDSNLIRRPLELILGELFDDQNPFYLTVSKWILSILNSGSASRLFQMLAYVLKTNNGRTRKVFSTELTSIKSSTIWKNEDVSTYKSLLLVTLMRFLNIKSNTHAKSIRSALILLDILLDGTEQNFKDIVIF-LLQMSSKYIAEEGIEPELIAVSLLDIVSKVLRLSHDNGIKLYIDFLVTSVSNMKSPLIVTAYVKLLSESIVYFENSIFRMILPLSASLVQCVQRLFLLEKREGGYYQPIALLLGGLE------------ELLEISHGYLVTEEREGYFSGSNLKGDFIQSVVSNVFSSDSSNEESKIQGERDVILQSFRQVI-----------------SCCLDIWYWAHNISCKSNDDSSLDATNHNSYKFKFRSKKLLETLFLELLENLISIRSDIPHLLYGVIIRYNRTASVKFSNRLFNYVDSVENSAMEEFYGDFLLFFREVATNYNLYSDVSLSILKLVALISGKVSKTQFGEQKRVRREISDVFFKYLPNAFINFTNLYRGHPDSFKDLEF-VVWRVQYIVNDQIGGDKFNTTLATIVNQCLTPYIKPKSEKTIPGYVLELAAVVSHLGSKVKSWRLLIGSDQTWEKIIWSIYPENKSKILNDLLLEIGSKRSSVTPTLITFNLGSDSEVEYKCQNLLK-ISYLLMVS----PNDAYLLHFSSLISCIFHYLVSKDLKGSCWILLRVLLLRFSESHF....... |
1543 |
| 11 | -11.700 | [YU] KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily) |
ali follow.. |
8 | 6 | ................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DQHELEQVIQLLQHAHSTDQRNVQVQLVQLNEHQ-KFCCYLVYILSDMKEMIDATSRS-LAGLLL---------------KNNIRAKWNKYPQDVKFFVRTTCLKSIGDQ--EPLIRATVG--IIVTTIVMEENMCDWP-DLLDTLATVLMQPDELMQE-----------------GALGALQKVFEDSADRYESEFLRPIMP----KLLVFYEHHAAKMRALAMNCVNCILMVNNDPIDFAIDQFLTSLFARHND-NDEEVQKQLCRSLTLLLD-----THIEKMMPHLPNVIEYIIKKTQDHNESIALEACEFWLSIA-ENSDICRTMVLPHLDKLIPVLLGSMRYSETDPALKANDEDSSVPDREEDIKPRFHKSKQHGLGGLVESDDEEDEDDDDDGGGD---NIRRCSAASLDVLASIFGKDLLDKLFPLLKDTLMND---NWLVKESGILALGAIAEGCMDGV-------VPHLGELIPFMLAMMFDKKPLVRSITCWTLSRYSSHIASDENFRQQFFKD--VLANLLRCSLDGNKKVQEAACSAFATLEEEAGEQLIPFLGEILDQLVKAFQCYQAKNLLILYDAIGTLANSVGDALSHPVYVQMLMPPLMEWERLSDEDKELFPLLECISAIVSAMGQSFLPYIQPVFTR----------CCSLIEKCVQQNQQHIMAPDQVEAPETDFIIVALDLLSGL-AESLPEHMDPLVANSKLVELMLFCSLDVTPDVR------QSCFALLGDLTKACPERVLPQSSNFIFFLAQNLDPSKISVCNNAIWALGELALKMGPAMKQ---------IGPIIEPLIVVINSQQNMQRT---------------------------------------------------LLENTAITIGRLGQCC-------GEELAPHISRFVRPCCYSLRNIKDNAEKESAFIG-----LCNMINMNPVGVLNDFIFWCDAIAS------TVPTDSLRVLFAGILQSFKQ---QVGDFNWNNFILQLPPPLRERLSAFYQI.................................................... |
883 |
| 12 | -11.200 | [YU] KOG1993 Nuclear transport receptor KAP120 (importin beta superfamily) |
ali follow.. |
8 | 1 | .................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MQVDPVVYQLQSQDPIAVKDAEGHLNNWK-KEPGFFGKLYSIFLDKQNDMSLRWIAIIQLRIDIIWRKNTKMSLLPEERDFIRCNALLGSIKSENLLSIQNALVVSRIARL--------DYPTEWFHDLLGKLQQ------SLGTGDYDVALRLLITLHHIIKAMAGNRLLRSRQIFYKLAPELLTILQPILHSSLSSWMMILESSKEIKDSTLLSYMQ-TLKACRRLVVFGFQNPSESEFSERMLAFCAVHQRKLLSMLGTMRSPIVVGECLEMAFAHAFLFNKPFFDFSFYSPCLTKFPATID----------------YISLHYDFLGQISSHLSSYKEKFEESSKNFEKLVIMSLRVFILVIQEFCNTKSSHPETAQVLYNSFLVDNRINNLLDLLITKLLILKEEDFEEWTDSPQQWVLEQSTQDVEFN-VRPCAEKLLKCFFDAYGDIIV---SPFKDMIYSVFECPKTLTQAVQQDTLISSFGVGYTQLKSIFPFAKW-LQEAAVPNMASINDIGISRVYRRRIAIFLSQWIEDSSSEQLLEYKLYCSFLNLTDPCNDAVVILTTIDAFKTVLDDNFSENSFLSIKENLFVHVLSLFKAFESVDARTSILSLLGTLLARAGEHVAPMEST--------------IASLLSQLWDGWKKEPLLRARVLAVMHQFVNAIKAKSF-----EFSTFLYTVIEYCVNPESPE------------HVIFEADAMELWSTF-LMYIQKLPETFTLLIPHLLYHLSQATSTL-PFVLMIVSSYQLLDNTVLMKDYSFTIFEKLNDLLDDVKNE-----------------------------------------------------TLQALCKTVCLLIETTPMDMIYESLLNSSL----LSRLLLSIATN------------------------------DKHPQVLIEYLLVVSRISLREPEL---KVCQTKNINIAMLIGNWILLNDHINHSKDRK-------LNTLALSSLLRTNHPDVLAVLDSIMNLWFSVL................................ |
891 |
| 13 | -11.100 | [U] COG5215 Karyopherin (importin) beta |
ali follow.. |
7 | 1 | .................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MSTAEFAQLLENSILSPDQNTQLKKLSNDNFLQFAGLSSQVLIDENT--GRILAALTL---------KNELVSKDSVKTQQFAQR-TQVSPEAKNQIKTNALT---ALVSIE-------------------------------------PRIANAAAQLIAAIADIELPHG---------------------AWPELMKIMVDNTGAEQPENVKRASLLALGYMCESAD---VSSSNNILIAIVQGAQSTETSKAVRLAALNALADSLIFIKNN--EREGERNYLMQVVCEA-----------------------------------------------------QAEDIEVQAAAFGC-----LCKIMSLYYTFMKPYMEQALYALTIATMKSPN-----DKVASMTVEFWSTICEEEIDIAYEL-AQFPQSPLQSYQNEDPEDDDWNVSMSAGACLQLFAQNCGNHILE-------PVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRT--HQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDH--PKVATNCSWTIINLVEQLAE----------ATPSPIYNFYPALVDGLIGAANRDNEFNARASAFSALTTMVEYATDTVAE------TSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMGLFFRLLEKKDSAIEDDVFYAISALAASLGKGFEK---------LETFSPYLLKAL-----------NQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNGADFIPYLNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQ-----DWVIDYIKRTRSGQLFS------------------QATKDTARWAREQQKRQLS........... |
860 |
| 14 | -11.000 | [OZ] COG5234 Beta-tubulin folding cofactor D |
ali follow.. |
10 | 31 | ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DDRSSSHSVEKLKDVAVKYLQFCQFQPT----------LLDK-----LSKYV-------PNLASYLLKVKNIGKCNSITVIL--YQFCKIRGYKAVRVL-----FPVGVQYIKELYTLLNEHYI--TPFPLNSLDDSLDVKKTIYTIAIKYLENSGIDKEASCLVLSRLFSRDDGLDLLLGFLHHCESSWFKRSFLKICPRNDCLQTVDVAFQFLNVAREDLVGQENSALRKLLCKCYTRLGIVLLPVNSSPNWKYSISNPDSFFQLPDDSNEEVHIYLEVIVDFLLSSVS-----DIDSFVRWSAAKGLAKIISRLPWNLAEQVIDAIIELMTENMFLNPIENTVNISITSP---------------LVWHGAILFFAKLAGAGLIKYSCLHILPLIEVGLSYEVRYGTRVTGQSIRDASCYFVWSFYHCYSKSAIEGLQTNLILCLLQTVLFDN---NVRRAATAALFEVINCYGDLCMKVAHFPQFRSCVFQRLFTNLQQLSAFSLRQLSIKYPKELSIYLPPILDYLSVGNADFIFGYTIGLASIIGGFLSISFPFDINRIHDLLSHKNLLSLKKFSRQQQTKIILGILKGIQQIFAN-RAFFSEAFSVIIAAIDLQEETIIKDISDAYSVLVKFDDM--------EETLEVLLDYIRKCSTSKEARIVYIILQNLPNISFRYQKK------------------ICKLLLDIYPQLHSIDYQAPVANALQNIIPFTYEK------TESIEEFVKELLQVCSNYLT-----DTRGDVGSWIRKPAMKAISSLLVKDSSGKKLSEDIVWCCISYIIRQTFDKIDSLRGLAYQALEQIRVHYLIRRCEALTNIINRISFRNNPNMDGEVLNELNISLLEIPNLRLQAFYGITVFTADGFGSDLAVKCFEFYLSYVYQLEDSFKKSNSRYGKRDLLQLYIDILSSEDEIARFYFP-IMKSFTSLLAYGCFTDFQNVKGMSKAIFIVQRRALTCKSPGG-----LSAILELYRTLFLSKNELLRHHALKYTANLLLYQAADTL--LYAKSIGLLTFLPN-------ELNQKLLTLDWFVPVSQNATFVKQLRNIIQKQ............................. |
1099 |
| 15 | -10.900 | [U] KOG2081 Nuclear transport regulator |
ali follow.. |
10 | 1 | .........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MDTYSVD--VVYQAISALFQG---PKEQEKANKWLQDF------------QKSIYSWTIADELLHQKRDLH--TMRNKIQNS------------SELPPHTHESLRDSLITHIGQIDEQTDNVIV--------------------------------TQLSLAVADLA----------------------------LLMASWREPINDLLVTLAP--HQCAIWPLLEVLKV---------LPEEIDSRYLRLGANRREEVHKQLDASAECVLKFLCMCLQREDLDQQRVWNAALRTYSAWLVIHAFPVSHVYNNALTQLAFRLLSLPETSGKLHDNATECVCALLSCINTRQDGASDPESSFEAQLFGAVCMLETPYHLSVAHEDTNYCRIFTSLCDAFFYDLLADAQKPHYSLKGLDLVLLCVGHFDYEVAEITFHLWYKLSEDLFQRNEDKLTVLFRPHIERLISALFRHSQMESDHDGL-ENNNFFDFRRKVSDLIKDVAFIVGSGACFKQMFHILQAPETTWESTMQNVAKNILPDENEVIPKVVEAILNMSEQTHIAVRYT-----AILLIGELCD-ENHPESLEAVLNFLLYALQQKNGLAPAAAIALTSICSACRQKMVCHISGLVEIARSLDSFQINNDVAIGLLKGISLILTRLPREQLQPALREIVGFQLQPLAQLVDSTGSTPQKGERVYWIDRACAIIRHTNPDVPDNVEHPTVAILNDAWQLISRVMDKSDLRIMERTCRLIRYGIRMVRKQ------------AMMLVEPLIKQMVVLYSVQHHSC-----------------------------------------------------FLYVGSILVDEFAKSSECIGGLLEMLQAFIEPTFGLLQMENGLKNNPDTLLQSSLITPI--CSLDHREANSSVMKFFINLLVSNNHSRNTECRPLVVELASQHGGALVMNLIASVFQLHSYMLVDVAEVLHELLEALPKKNSGGYVTATQQQLDEFSSTVLRADTTKAISQALKTFTRLF............ |
913 |
| 16 | -10.700 | [YU] KOG1241 Karyopherin (importin) beta 1 |
ali follow.. |
8 | 1 | .................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MTSDIAMQL--------IAILEKTVS----PDKNELLSAKNFLEQAAASNLPEFLKALSEILVN-----------TANSAVARMAAGLQL---------KNHLTSKDEKVSQQYQDRWHQFPSEIRELIKNNILA---ALGTENTRPSCAAQCVAYVAVIELP--------------INRWPMLIQTLVNKVVSEGSSEMHRESALEAIGYICQDIRFGVMENQSNDVLTAIIHGMRKVEPSNHVRLAATTALHNSLETKSNFEKDMERNFIMEVVCEAT----QCQDSQICVAALQCLVKIMTLYYQYMEPYMAQALFPITLA--------------------------AMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGR---------APQRVSKHYARGALQFLTPVLVEKLTKQDECDDEDTWSPAKAASVCLMVL------ATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVL----NGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAANETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEAAVTNDGETPETYALSPY----------------FEYIITQLLETTDRSDGA---------------------------QANLRCAAYQALMDMIKNSPLDCYLVVQRTT--LVILERLNQVMQMETQINNHSDRHQFNDLQSLLCATLQSVLRKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAQFAK---------MPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNE-------------------------------IMTVLINNLTEPTIHRTVKPQVLSAFGDIALSI-HFLPYLSMVLDMLRVASNLQTDANNFDMNEYINELRESILEAYTGII--QGLKGVDQTAHTDVMHMEPHLMHIISFIKRIAQEGDVSDSMLAS--AAGFIGDLCTSFGPRLYPLLDD--AIITQFLAKRSKAQRTKMLCTWAVKEIKKI......... |
877 |
| 17 | -9.960 | [R] COG5219 Uncharacterized conserved protein, contains RING Zn-finger |
ali follow.. |
9 | 2 | ............................................................................................KKKSTDLYGRKNPGMQSMSGSFSSLQIALDESSSNFSTIYEPPDLSGLDAEMIVIVKNLQKRDIVTKCRALQD-LIQWNDPSQFDNEQFLNALAVLFPRLSIEVERHVRLKIFVFMSVLSS-----------ALQKKLAPWLKFYITPWVMGFFD--SDRAVSVSAKDSFKNLLSEEKWPHVWLGSTIAPIVTDVF--SLTDLRFFSNEEAESKVTRVKSSCLLTLSFLFKQTADLENLETDKKIDKQTFKSSLYENLSTLFKSDEFWSLVSSPQDGVTVSLSDLLLIILKYDKPFVTQYKEKYFKRVSRMISRLTSLTCVPM--------LRLLSNMISNFPNEVHQFANDSKRPLSKLFSNLITK-NSGFYTSLLNLFKSIGAMQLVPSIESVDELCDAFLETANQEYDCLLNFLSFVYTDSSDPQIKDRDRLRTIFTRYFKGEFVLRCSTSDFDHCLQSVFDKNSDFASLWNEVLFGFFNDESMDIETIPFDSLSRNLSLTVQTVLY--------LKNRNFQTGNEVMSILGPCLSFLMKLSTHKNERIACLSASQLITVCHIFSDTTLIKPVKELFQKYLVNDLPSSILKLGPQSPAFTLDILLLLKDYADLSEPWENVANQFTVSFDELENIRVLNSLPSLFADGKLRGKISLVKTLVEYYDTAVFAQNPGNDWDMIRACIGSKEVPEETIKNILFTTLEYFLTNDWVDNHLIILCASLHSLKAHLPTIFDENKSLYSLLPVILFSKPEDDGHVAAHFESIFSLLKEK--ALEDSGFSLKLCSEVQEWSLNKVLNGSINEKLAADKCVLVFNSFGKLPSNFFTFPASFWDAKISSCIPFFSNKLFIDQDFILGFLDLVASEPINVDMTDVGTQFVHIFHAS--QNGIQSIIDVPIRDAGIFVESFECYFKGEVVKFMR-DIDGKMPVLFKRFKNLSSAENTTSFSIFAAQGLTDFLIVVSNLLEMDEKHVDVVLGKLGLSSSKSPI-----------FVSSILEGLKPLEVDSEIIQRIRFKAVNDLTGKLHSANEVSKSLLILNAATTQQI-----TEKPLLPITRCRLFLENITNWCSESGIKSLELL--VCCFLRFMYYFLPTVFSLSGSYWNSIFDYIKYAMKMSVVDAPIVKALRLYNALSKNYEMNSDIKDCIVESNESMNYLLLKRFLFTHESTLRNSVTARMCNQYLVKLLENCPGK-FQYQEFFPSLCNSNDLQMESVCMKFLREKLSHELKELT------------VYYMVESDYEPDVSLCPELLSLAIDFPGDPFVMVSKMEKYEHALRVYLWDLIFYHF-----EETTYNIKLSIINQLHA----------MDLLRPLLN-TLVEILNLSYDRPINVDKYPKIDYNLMDYSSATDRIRCLAIHIYYQCLRHLSSSWSEVKN------RAFTSTVESFTGYNVSPLLI----------------------------------SASLDDVERSIESEDFQSVGDVNVKVNRNTREISFIYNVDEHKLEMAIKIPSVYPLQNVQVEGIERVGVNERQWRSLASQSILSITDALL-KKNISMHFEGVEECAICYSVLSVERTLPNK-RHKFHA-----SCLYKWFKSSNSSR-------------PLCRSSFTF.................................................................................. |
1609 |
| 18 | -9.840 | [YU] COG5101 Importin beta-related nuclear transport receptor |
ali follow.. |
9 | 1 | ......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MEGILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNPDAQKADQILQFIADKLITRKWKLLPNDHRIGIRNFVVGMIISMCQDDELINKSTLVQILK--------QEWPPEFIPELIGSSSSSV-LLSEE--------------------VFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCFQVLEQGSSSSLIVATLESLL-------LHWIPYLELLSTKF--MTSPDTRAITLKCLTEVSN-ATYANANGNDQSFLQDLAMFALLESDESLRELLLNAHQYLIQLSKIEERELFK-WHNLVADLFYEVQRLPATEMSPLIQLSVGSQAISTGSGALNPEYMKRFENMVRPEEVLVVENDEGEIVREFVKESDTIQLYKSEREVLVYLTHLNVIDTEEIMISKLARQIDGSEWSWHNINTLSWAIGSISGTMSEDTEKRFV--VTVIKDLLDLTVKRGKDNKAVVASDIMYVVGQYPRFLKAHWNFLRTVILKLFMHETHEGVQDMACDTFIKIVQKCKYHFVIQQPRESEPFIQTIIRDIQKTTADLQPQQVHTFYKACGIIISEERSVAERNRLLSDLMQLPNMAWDTIVEQSTATPKVRGLRTIKKEILKLVETYISKARNLDDVVKVLVEPLLNAVLEDYMNNVPDARDAEVLNCMTTVVEKVGHMIPQGV-ILILQSVFECTLDMINKDFTE-------------YPEHRVEFYKLLKVINEKSFAAFPAAFKLFVDAICWAFKHNNRDVEVNGLQIALDLVKNIERMGNVPFANEFHKNYFFIFVSETFFVLTDSDHKSGFSKQALLLMKLISLVYDNKISVPLYQEAEVPQGTSNQVYLSQYLANMLSNAFPHLTSEQIASFLSALTKQYKDLVVFKGTLRDFLVQIKEVGAEDKENALMEQNRLEREKAAKIGGLLKPS.............................................................................................................................. |
1080 |
| 19 | -9.780 | [BD] COG5098 Chromosome condensation complex Condensin, subunit D2 |
ali follow.. |
10 | 6 | ...............................................................................................................................................LSEYLTKFQTTDRESRLQDPSRELNVIIDQLAVSPEDASPDSLEALIDLCHDFPHQLSYLISSSLSNLSK-ANLSSNVNFTEIGGLIPQLIQVLLTFLQDELHKVSSQSTNLLESITKLLEINLSKIFQTTPEKDLFIGLFTRPLFVLLEIEPVTKVSSLKMFIQRILAMCVKNHGQSSSIQSSLMTNLTYFLHLSVFNAELLKLLNDEYNYPQLTED------------------------------ILKEISTRVFNAKDTTGPKAISNFLIKLSELSPGIMLRQMNL----------------------------------VITLLNNSSITLRCSVVEACGNIVPQTMEHYKQQIAVLIELLEERFQDSNP-----RTKAIQGCSKICDLSSKFNKSK----------AKFTSLAVRSLQDRS-----------------------SLVRRNSVKLLSKLLLKHPFKAIHGSQLRLSEWEEYLKGSESQLNSTLKKVESQETLNDTIERSLIEEEVEQDEGQCRTELEGSFNKSAELSRIENEVENINATNTSVLMKLKLMIVYYKDAIS-FIKEIHKSIELISN--LLFSKNRNEV--------------------------LESMDFLVLADAFDIELSEFGIKKMLH--GTNDEGTSIVHLIECYKQLFLTAPDSC-NMQEKAAHIAKNLINL---SIGASIADLASLEQLLGM---MYEQKLIDQHVINILWAIYNSASKASMQKEQNVNNRDSEKGFSKEQIHGSIIILG-----MLSLADNEIALKGLESLLNIGLGAVGLKDLT-ERMVPKRSTIITKAINQELEDVAVKKLYAIIINYTKDNEYYPMCE-----QALSALFTISSKPDILATDLIR---------------EKTMMTFGKPEEEDSILSLEQSSRVVSLSQL--LFIVGQVAIKTLVYLEKCEAEFKKRKIEAETRNGKVKNQGADVTNTTQDNGGDKELEMIGGTNEDDFTDAIQFVKENELLFGEKSILGKFCPIVEVSNSSRFSDPMLQRTATLCLEKLMCLSSKYCEK----------SLPLLITVMEKSPDPTIRSNAVLGLGDMAVCFNNLVD-----------TDYLYRRLHDENLMVQRTCLMTVTFLILAGQVKVKG-----LGEMAKCLDNPDQGISDMCRLFFTELASK....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
1081 |
| 20 | -9.760 | [YU] KOG2022 Nuclear transport receptor LGL2 (importin beta superfamily) |
ali follow.. |
8 | 1 | .........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MDGNEIA--HAKKLVYDLYSGSLSPSAIAATEKELQKA------------QRSQQGWNIGLF--MLQSKDVYEQFFGALTLQMKINT-----QLETLSDKDLVQLFVQLLQRKVICEEASLKVIYCLFCNKLEFFNADMNAASVLNNLFPPASSRNAQLTASYINELLLELSFSIYTKENEDALFNNVFRPC--SNIIVSVLVFIFTNYSLDLSKEKNVAALEEALNCMIAISSYLAKASVSQSVLPAFTEC--MDLTVNCIALDEVSEKAMNCLADLLANYSNFITQP-ERLWTILTGPWGETHLQQELEDPDS--------------------------------------GEENDYSFLNIVIGFAEAMLPQIIDHIQEEKSIRLLYILASLLSFPGYAIVEEKVSWRTLEF-----------------------WTTLIEDFSMSKAATDPSKDEIFKQIAFSVVEKAWWKMLLPSPE-SRDSFNSYRRDLGDSSYSIFGERLYAMYITTIENFFSDGTGSPQSLLCCILEYDTNDSDTLDAWLTRLFETSFAIKASAFQNPQLLKTCSQLLSSCSCFLQNHPQYLNIS-LFDALHISETSIQMTVSRSIHTLCTTCASHLLTEIDGFMAVVEEVYVPSVLEKIYSSVGYVTQR-----DIELRISYLMRLLNCILAQLQP---------SLYPNLEIFENVLKSCLQSVAGVALS--SCIAEFQAKLISFLTHSESMQYSDVVGLICKIMIAGLNEVEPSPFSLPIVTTIQYFCDRFTEFPAAVLLTLGSAILTCPYGQTDIIDK--------------------------------------VLIDMCSSIQNSVVIINEESFMNNIDITVELYHFFSIILQKHPSETMYPDFTQLILNRAIN-----LGKPERLLESAAGQFIISFITSEKSDLLNTHTDFVNAIRSPLIAKILL---GFGGNASRSSLPLLSDILGKLKAQVSNEIKRRFLTDL---------------LKARIKDKVKQFWILC............ |
975 |
| 21 | -9.680 | [K] KOG3779 Homeobox transcription factor prospero |
ali follow.. |
15 | 585 | .................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LKKAKLMFFYTR----SSNMLKTYFSDVKFNRCITSQLIKWF-SNFR---EFYYIQ--MEKYARQAINDG---VTSTEELSI--YRALNMHYNKANDEVPERITLREFFN---AIIAGKDVDPSWKKAIYKVICKLDSEVPE............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
723 |
| 22 | -9.590 | [Z] COG5022 Myosin heavy chain |
ali follow.. |
12 | 84 | .......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LNEPSVLDALSTRYNQ--SGIVLIAVNPFQRLPNLYTHEIVRA-DPAEDSYKCMNQEHKNQTIIGE--GAGKTVSARYIMRYFASVQ-QLTAVENEINPIMEAF---GNSKTSSRF--KYIQILFDGNATIIGAKIQTYLLERSRLVFQPNYHSSEQLEKWKLVEYLKQGNGVNDKEEIDNDTCECIFSLLAA--LHIGNIEVKHSRNDAYIDSKNENLINATSLLGVDPSSLVKWLTKRKIKMASEGILKPLNEFQAVVARDS----------VAKFLYASLFDWLVATINKALMYSADKSNQTA-IYGFE-------HFKKN-----------SFEQFCINYANEKLQQEFYRHVFKLEQEEYAAEGLNWSYILGILSLLDEECRMPTNSDENWVSKLNDAFSKPEFKNSYQKSRFGNKEFTIKHYALDVVYCAEGFIDKNR-----------DTISDELLELFTNSDVPFVKDLVLFRLEQTAPPADTKKIK-------------TKPKSNTLGSMFKSSLVSLMSTINETNAHYI............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ |
662 |
| 23 | -9.550 | [T] COG5422 RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases |
ali follow.. |
8 | 291 | .PPPGLSSMDSNGSSIENNFLYTKRRANTSDSFDSVLSDSSTTPTISSSVQVNSLAFITSSLSAITKEPEAPETEYNPHGVFTLLTECYSSTCSRNRLCYSISCPRRLEQQARLHLKVQPVLSGGSTSITDKQEEDHRLWSENVPKQVVDQIDVREWKRQEIIFEVIYTERDFVRDLEYIR-DFWIKPLSVIPENNRQQFIRCVFHNIMQIHAVN--SRLSNALNRTQTLQPVVNTIGDLFLDPFIKYGANQAIAKFEFEREKS-----------TNRNFANYVHEV---------ERLRESRKLELNGYLTKPTTRLARYP--------------------------------------------------------------------LLLSGVLK------TDKDNPDTENIPR-----VIEMIREFLTKLNYETGKTENRLS----------LLQLNEQL----CSPADRAKLTLFDPSRLLIFKVKLKASSYSNNDIHMFLLDNFLLLCKIKIQMKRRVH-------KLHLRP------------------------LELLSISYIEDSPSRGSLPRRPSSALLTNPISITKSNPPPVKAYGLQLVFIGARGFSISLYLNTLIARDQWKQHIEKQQDIIRKRHLVFESRGICCQSWFTGNKLLCAVAYDAGRSSRKSNNGSCLEPIFKLQLPNISQLDVIEEHNVLLLLAEKILYELP---LDALDSVEQINSKSLRRVTGFVKTGFCMQRILV--AVKSTVNTTLRIYEADRALKNKKPFGNQATLKIF-TEVQMPMEALSVHDIISRFLEKREDIRPIAMFRLRGEFLLCYSDFAFFVNTNGWKSRQSWMINDFIE-IRNAETAE------LVQI---IMGQNIKLLTDGRGLISEGG..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... |
1124 |
| 24 | -9.000 | [LA] KOG2044 5`-3` exonuclease HKE1/RAT1 |
ali follow.. |
12 | 87 | ...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DHLFTLVRPRKILYLAID--GVAPRAKMNQQRSRRFRAAKDAAEAEA--EKAETCDSNVIGPFMAILSVA----LQYYIQS-RLNHNPGWRYVKVILSDSNVPGEGE--HKIMSYI--RLQRNLPGFDPNTHCLYGLDADLIMLSLATHEVHLREVITLREYLQYERIIDDGNDF--NLLMHVYRKEDSGEVLLDAVNEDKIFQKRTRIKQSMDNNEEMKQRSRRDPSEVPPEPIDDKIKLGEPGYKERYYAEKFSTTNPEETEQIKQDMVLKYVEGLCWAPFASDLK--LPDLEITFFIGEPFKPFDQLMGTASSNALPGEYRKLMTD--PSSPILKFYPADFE-----------LDMNGK--RFAWQGIA-KLPFIEEKLLLAA................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. |
590 |
