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Query: [S] COG5373 Predicted membrane protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLEAIALLAFVMALAAFLGGRRSAERLDREIESLKAEIARLAKEGMGEPGPDLATGRPSEAGVPSVAGTEATADGPWSRAREGAGTSHDESAAGRESGDGAIDGPVAPSAAAARAESLESRIGGRWPVWVGGLALALGGYFLVQYSIEAGLLSPAVRLTLAAIFGLALGVAGEVIRRRDVPAIADRFRNAMIPGVLTAAGAVTLFGVVYAAYGIYDFIGTGAAFVLLALVSLATVGLSLLHGQALAGLGLLASLLTPLFVSSGEPRPWVLFGFLAVAWLATLAASRLRRWSVVPTLANAGLGLWGLAYVALATPFEAPPVTFALLVMIAGVALIWPGRAERTAEPSGTTQIGAASEPGAWERLFTPPYLAISISAAIVATVLALLFISPAVDAARFPVSDFVVIVVALAAAGSLRPAAIYAALLAAFGAVAGTWSLTALSGVLAYLDPSFAGSPPEIVVPGRTAMLTAMTLSALFILLGGFVLARRPAGDRQFAALWAGIAAVVPNALLAMSFVMTGSFAFDLPHGLAAFAGGIFLLGLVEWLYRRSAGAGDADVDGGLPALGSFGLFVIGLHAWTDGLVTTLAIALLGAGYSFATRLRSWPVLPWVTVAGAVVILARIAWEPTIVGPGNLGTTPVFNALLPGYGIPALLLVASAYLLQAWPDLRVRNLLQALASLFVLLTLAILVRHAMNRGVLDSSVPTLGEQAIYTLLAIGASGIFMTLDGRSPSPVFRYGGMALGVLSMLSVLGAHLVGLNPYFSGELLGSLPFFDLLLIGYLLPAIGYFGLAWYARGRRPLPYVVALAVSGAILAFAWATLSVRRFWQGQNVADWKGFLQGETYTYSVVWLVLGVLLLVAGSRLDAKSIRIASAVLVFVAVLKVFLVDMSNLEGFLRALSFIGLGAVLIGIGRFYQKILSGSAGNAGEGARRALast
1 -209.000[S] COG5373 Predicted membrane protein  ali  100  1MLEAIALLAFVMALAAFLGGRRSAERLDREIESLKAEIARLAKEGMGEPGPDLATGRPSEAGVPSVAGTEATADGPWSRAREGAGTSHDESAAGRESGDGAIDGPVAPSAAAARAESLESRIGGRWPVWVGGLALALGGYFLVQYSIEAGLLSPAVRLTLAAIFGLALGVAGEVIRRRDVPAIADRFRNAMIPGVLTAAGAVTLFGVVYAAYGIYDFIGTGAAFVLLALVSLATVGLSLLHGQALAGLGLLASLLTPLFVSSGEPRPWVLFGFLAVAWLATLAASRLRRWSVVPTLANAGLGLWGLAYVALATPFEAPPVTFALLVMIAGVALIWPGRAERTAEPSGTTQIGAASEPGAWERLFTPPYLAISISAAIVATVLALLFISPAVDAARFPVSDFVVIVVALAAAGSLRPAAIYAALLAAFGAVAGTWSLTALSGVLAYLDPSFAGSPPEIVVPGRTAMLTAMTLSALFILLGGFVLARRPAGDRQFAALWAGIAAVVPNALLAMSFVMTGSFAFDLPHGLAAFAGGIFLLGLVEWLYRRSAGAGDADVDGGLPALGSFGLFVIGLHAWTDGLVTTLAIALLGAGYSFATRLRSWPVLPWVTVAGAVVILARIAWEPTIVGPGNLGTTPVFNALLPGYGIPALLLVASAYLLQAWPDLRVRNLLQALASLFVLLTLAILVRHAMNRGVLDSSVPTLGEQAIYTLLAIGASGIFMTLDGRSPSPVFRYGGMALGVLSMLSVLGAHLVGLNPYFSGELLGSLPFFDLLLIGYLLPAIGYFGLAWYARGRRPLPYVVALAVSGAILAFAWATLSVRRFWQGQNVADWKGFLQGETYTYSVVWLVLGVLLLVAGSRLDAKSIRIASAVLVFVAVLKVFLVDMSNLEGFLRALSFIGLGAVLIGIGRFYQKILSGSAGNAGEGARRA 928
2 -11.900[R] KOG4812 Golgi-associated protein/Nedd4 WW domain-binding protein  ali follow..  10  32....................SNPAPQIVQAASSAPALETDSSPPPYSSITVEVPTTSDTEVYGEFYPVPPPYSVATSLPTYDEAEKAKAAAMAAAAAETSQRIQEEECPPRDDFSDADQLRVGNDLAFFMAFIFNWLG--FCLSFCITN---TIAGRYGAICGFGLSLIKWILIVRFS-DYFTGYFNGQYWLWWIFLVLGLLLFFRGFVNVRNMSESMAAAHRTRYFFLL.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 242
3 -11.600[S] COG3147 Uncharacterized protein conserved in bacteria  ali follow..  9  14...VLVALGVIVLPGLLDGQKKHYQDEFAAIDMMPAATQALPTQPPEGAAEEVRAGDAAAPSLDPSRMASNNVELDPIPVETPKPKPVEKPKPQPKPQQPVVAASTPTPAPQPVADDKPAPTGKAYVVQLGALKLRSAGVYTSPSTPVQGKI---TRILV-----------GPDASKDKMKGSLGE-----LKQISGLSGVVMGY................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 221
4 -11.300[A] KOG2412 Nuclear-export-signal (NES)-containing protein/polyadenylated-RNA export factor  ali follow..  12  182..................ELLRQKKDEEERKRKEAEAKLAQQKQEEERKKIEEQNEKERQLKKEHEAKLLQQKDKLGKAVTNFDKISKMFWHYKDKIAQIKQDIVLPIKKADVNVRNLLSRHKRKINPKFGQLTYHWILNFIAKAVVHQA---PLGKLTLYLLLQELFMA--QNMGWKRNNENKWEDNTSYDERM---GGILSLFAIITRL--LARICNNTHFVILGSWWDAAAVQFLQAYGQASKLLILIGEELTSRMAEKKYVGAARLRILL.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 522
5 -10.600[S] COG4872 Predicted membrane protein  ali follow..  15  1..............................................................................................................................MATLGGLLLGAAVIMLVAANWQE--MPRLMRIGVIFVLIWASYLGGAWRQAR---------GDKVFPAALYVLGAASFGAGIALVGQMYHISGDVYSAALYWTLGVLASAFLLRAQALAAFGAGVACFYLSTFVFADSNLSGADISYGPLLLLAGVAAALFTRSRHAAHFLALFSIGWCLLLYAGQENKTVLLLMIVIGIGLILADGL.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 200
6 -10.600[G] COG5309 Exo-beta-1,3-glucanase  ali follow..  10  1MRFSNFLTVSALLTGALGAPAVRHKHEKRDVVTATVHAQVTVVVSGNSGETIVPVNENAVVATTSSTAVASQATTSTLEPTTSANVVTSQQQTSTLQSSEAASTVGSSTSSSPSSSSSTSSSASSSASSSISASGAKGITY-IRYGVDCSNVLQAKTSSQKLFLGITVSVGNELVNGGSATTTQVGEYVSTAKSALTSAGYTGSVVSVYMAVNAHAYFDENTA-AGPWVLEQIERVYTACGGKKDVVITETG----P--VPSKANQEAAISSIKSSCGSSAYLFTAFDLWK............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 372
7 -10.500[S] KOG4829 Uncharacterized conserved protein  ali follow..  7  77..................AEEQVATSGSDESLPQKPQKRKQVQDANETKKLKRSKTQENNSDEDDDVDSQPTAAQLKEAARPENAYAVVTVRQKKKQKHQQRLEAQKSQSSNKDAKVNKEYLRQDW-------------ISIQQTAFDVEKLDDEWPTALEYLASS---AARSKISQLAEEVIQKLDKEGEKLEDEAERRKLIESTQYRRARDLLQSFD..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 277
8 -10.400[R] KOG2295 C2H2 Zn-finger protein  ali follow..  11  423..................GPQSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVGKDKVVETETIDLDKVKDGQPRALHRTSSIFLRNLAPSITRSEIEAVGYLRVAIADPLVERRWYRRGWIDVNIKEICWGLNNQRLAIVNRDLSRRVRPANGITAHKQVVRSDIKLC--AKIALNLDEKFRLWA-NGSGSTYGFNSQNPVLQNITDYLIEEASAEEEELLGLTGENKDTEGEPIE-RLVLYLRIV........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 719
9 -10.200[P] KOG1418 Tandem pore domain K+ channel  ali follow..  11  62..................QTSQAMKLLEKYIRKKYRHSVIFSQDSADIEQSSTPVGHTQSACQFSRNLTPEQRNGFYSTPLGPAPSEYHFPPGSPQFRESTIREEFKQQYRETWGHWFVRVGKFLYIQYMLLALMILGGYIFLEYDQQQLDLEVEKQVRLSESTLLA-----KYLKQWNCGQSNENRCLELITKAFIERSIKVERDIRGEGWR-YGNLACKTNLGRVATIIYGLIGIPL----MLFVLKIFGEHSIKWA-ITTFPVKWALFIVFFFMVVCSLIVSFWEKWDFLTAFYFFFVSLSTIGFGDVIPEHPRTACGNGLLEIKICYISVM................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 429
10 -9.870[T] KOG4566 Cytokine-inducible SH2 protein  ali follow..  11  283........................QSVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWY---GPITKLANGSFLVRDSSDDR-----------YLLSLSFRSHGKTLHTRIEHSNGR---------SFYEQPDVEGHTSIVDLIEHS--GSATYPVRLTNPVSRFMQVRSLQY---LCRFVIIQKLPLP-----------KMKDYL.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 530
11 -9.710[O] KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase  ali follow..  11  2.........................................................SSSSSTGYSKNNAAHIKQENTLRQRESSSISVSEELSSADERDAEDFSKEKPAAQSSLLRLESVVMPVIFTALALFTVVWDEAHFGKFGLRHEFYPPLGKMLVGLSGYLA----GSWDFLLEIYPDYLDYVKMRLFNASFSALCVPLAYFTAKAIGFSLPTVWLMTVLVLFENSYSTLGRFILLDSMLLFFTVASFFSFVMFHNQRSKPFSRKWWKWLLITGISLGCTISVKMVGLFIITMVGIYTVIDLWTFLADKSMSWKTYINHWLARIFGLIIVPFC.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 298
12 -9.650[N] COG3144 Flagellar hook-length control protein  ali follow..  9  442....................DIAALAPQTVAVNPMLNPAATVNPELAASSAMLAALGGRALAGSDERRAVSESGQEDLAQQIAAAAGQGTAQNQALNRAESQLVQTNATPVPLNKEMAADQLAERMMM-LGRMHIRMTVHFTAREALEQTM--PRLREMLA---GVQLTSVQQQSAGQQQRYTGQEQSGF--LNVATKRDGISYYA.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 674
13 -9.630[S] KOG2236 Uncharacterized conserved protein  ali follow..  8  1MSDDLFSKALENPDQDLNVELPKDDVDLGLLGDGGNERKTDEPVADAERSTGLGSGSSESESDSGSDSDSDSGSSGSEDDSADQDVEGEDEGGDAIENEDEDEDPSPSGPILSKNEILEETVEKTIITPIGVLKSAFENNIIIH-VLKEGIFCLEDRTLIGMLFG---------LQNPFYRIKLPDSKKNLFDELKVRLGEKAFIVTPDAHWIDTF------------LKRNKGTDASNGYDEELP.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 248
14 -9.580[T] KOG3535 Adaptor protein Disabled  ali follow..  9  1..............................MEMKTGRSCAPKGADHDFTLLSHSIPHHHLTILFGLTFVPKSFVILLVFFYCSLETMAQKSDISVETANATSGKPNPPSPKSRLAMLKRTKKASNASSDPFRFQ---GISYKGKL------------------IGEQDVMCAEAMRTAKSIIKAAGAHKTRITLQINIDGIKVL-GAVLHNFPVSRI-SDARAFGLVY--KFYGIKTAQAADQAVLAIR---MFQVVFEMKKKQIE...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 236
15 -9.300[D] COG3087 Cell division protein  ali follow..  12  143....................EQTPEQRQQTLQRQRQAQQLAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASSQQPYQDLLQTPAHTTAQSKPQQAAPVARAADAPKPTAEKKDERRWMVQCGSFRLAFEG---FDSKITTN--NGWNRVVI-----------GPVKGKENADSTLNRLKMAGHTNCIAAGG........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 319
16 -9.280[R] KOG0835 Cyclin L  ali follow..  11  1.....................................MASGPHSTATAAAAASSAAPSAGGSSSGTTTTTTTTTGGILIGDRLYSEVSLTIDHSLIPEERLSPTPSMQDGLDLPSETDLRILGCELIQAAGIVAMATGQVLFHRFFYSKSFVKHSFEIVAMACINLAVINVFHHLRQLRGKRTPSDQNYINTKNQVIKAERRVL---------------KELGFCVHVIIVMYLQVLECERNQTLVQTAMNDSLRTNVFVRFQPETIACACIYLAA-RALQIPLPTRPHW.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 267
17 -9.250[M] COG0810 Periplasmic protein TonB, links inner and outer membranes  ali follow..  9  16...GLSLAFHALLLITTDEAQVFAMPAGNPTQSVSINMVSMPKVAPAQPEQTQTEQSKPESVKPTPVQEVVKTPPAKPKVKPHKPKPQTVKKPVPAEQVPSKSVAKPQPEKVERTAETAQKPAPTPNQQPSQPTAASQGI---RY--------PRIARKRGI--GTVMYEI--WLDAQGNQIKQ---------QLLSSSGTEALDQSALEAIKQWKFSP------------------HILDGVPVAH------IHIPIRFKLEG........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 249
18 -9.230[T] KOG2290 Rhomboid family proteins  ali follow..  11  468.........LIHLGAKFSPCMRQDPQVHSFIRSARERCVQTSEEECSSTLAVWVKWPIHPSAPELAGHKRQFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKNSAGNHTNHPHMDCVITGR--SQVHCMDDVCGLLLWLSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHR----------IAIIYLLSGVTGNLASAIFAEVGPAGSQFGILACLFVELFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLS------------FAFLPYISFGKFDLYRKRCQIIIFQVVFLGLLAGLVVLFYVYPVRCEWCEFLTCI........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 838
19 -9.210[N] COG3351 Putative archaeal flagellar protein D/E  ali follow..  12  186..................ELAEKVEELEAEAAKPEEEVVVEVPEEEEKVEVVEEEVPPEEEEVVTPEVEVVEEEKKEEVEEEKEKEEVGKMSEKMKIPEDIASILFEEEPKKARLEEIPEDVVSIMIAWLGFLIDRVGI--VLEFYYEIGWISEKVLNQLRFARGTRPHHRDPEWKPAEKLTVQDHLISLLFIERLRGLRI---------TRDVLDKLEREVKMLEKTLDEFYGV..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 399
20 -9.050[S] COG4984 Predicted membrane protein  ali follow..  11  16...........................................................................................................................TLLFLLLGTGFFASGVITWIAANWDY--FSRFEKLYGVQSLFGVSILLSVFFEAKKKQVTSVLPLVFAFLAAVLLGAIFALIGQTYTGADPWEL------FAIWSICQIPFLLLF-PNVASALLLLVTANVALSLAISLLGDIVHMTIFLNMLFLVCYEYFGERLRDQNWRILPKIALFILVFAFGWALIVNNSVLLSWLLSAGLVYYY-------------------------------KERRFDFLNLIVLFFYLVVSICTKVLLSSGEDFLSDIFLVTILAFG---------------------------------------------------------GTIGAIITLIKWFKWHNPTASRVTWHIYPLFILLIIFCTGLLLITLFFSFGLEDEQ------LIYPSILFLIIALVMHFNQKEKADWFDIAIDMFMATGFILYFIFFLFDGENDLYLALMAILSVFLYQLRSSN---LRFLI-ASLFIIAFLVYIGFFDLRWYAYYEEHLGQFVLSAQQWIILGGLLLYYFFSLSEERPYTIKLLPIAWAMLLVGLAMNLDIFNRWTFLDTAQQTPEMSDLNDWFHVITG----------------------------------------FFTALTSDTWLIKSLHLLISITPIIFFVLISRRFELTKFLYASVLLTLLALCLGFI-----------------------------AVNETLACISLLLLAYLSVSRVL--FALALLGVIMLSYYYYLLS-IPLLHKSFLLMGVGIVLALVTFVLLRYNKAPQATLQAESHNT 649
21 -9.030[T] KOG4225 Sorbin and SH3 domain-containing protein  ali follow..  11  505..................GAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWY-RVGIMSFRKGERITLLRQVDENWYEGRIP------QGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASP--QDLFSYQALYSYIPQN---------------LELRDGDIVDVMKQFGTF--P--------------NYVKPLYL......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 816
22 -9.010[T] KOG3697 Adaptor protein SHC and related proteins  ali follow..  9  4....................RTKYNRFRNDVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPVDGPGSRLSGSCSAPSLAAPDGSAPSAPRAPAMSAARKGRPGDEPLPRPPRGAP------VLGPGVTYVVKYSLDFSTRTQITREAISRVCEAV--GAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISL-----------------TISTASLNLRTPDSKQIIANHH--MRSISFASG---------GDPDTTDYVAYVT............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 271
FFAS is supported by the NIH grant R01-GM087218-01
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Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Rychlewski L, Ye Y, Jaroszewski L, Godzik A. Integrated web service for improving alignment quality based on segments comparison. BMC Bioinformatics. 2004 Jul 22;5(1):98.