Scheduled maintenance will begin on May 30th, 2025. Server will be temporarily unavailable — learn more.
current user: public
If you have questions about the server, please let us know.

Query: [S] COG5542 Predicted integral membrane protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350    .  360    .  370    .  380    .  390    .  400    .  410    .  420    .
# Score Template Links and tools%idFirst MKLNESAMKNAEKKSNSYLAIRMTRSGYNYFKGICVCTFLLSTILYLGIAVIMSHLCVFDDTAMLYLRQNRSRLAESNIFRTLFISWIRWDAIYFVDMAVNGSLFEQEWAFSSLWPKIISFLAFRSKDVVLLGIVSCFASIFFHAIACYALYLLTKSIFSNQKMTAYTVIFYCFSPSGIYMSVGYTESLFAAFSFLGLLLFIKKQQYPAAFLWSLATLIRSNGIFWCIFFGMPAIGTLKISLERLQLTFMQVSQLVGYGTKCLIILVPFFYNQYLGFKLFCPGVAWCNKSLPLIYPAVQEKYWNVGFLRYWTLNNIPNFLFALLSIIPILFALFYSISGSTLHSFRSIKSHLVLSALYLYIGCFHMHTQVLNRMSSALPLLYWSMAHATLYAKSRNLKAFGHCILFVWIVYTVIQAGLYGSFLPPALast
1 -115.000[S] COG5542 Predicted integral membrane protein  ali  100  1MKLNESAMKNAEKKSNSYLAIRMTRSGYNYFKGICVCTFLLSTILYLGIAVIMSHLCVFDDTAMLYLRQNRSRLAESNIFRTLFISWIRWDAIYFVDMAVNGSLFEQEWAFSSLWPKIISFLAFRSKDVVLLGIVSCFASIFFHAIACYALYLLTKSIFSNQKMTAYTVIFYCFSPSGIYMSVGYTESLFAAFSFLGLLLFIKKQQYPAAFLWSLATLIRSNGIFWCIFFGMPAIGTLKISLERLQLTFMQVSQLVGYGTKCLIILVPFFYNQYLGFKLFCPGVAWCNKSLPLIYPAVQEKYWNVGFLRYWTLNNIPNFLFALLSIIPILFALFYSISGSTLHSFRSIKSHLVLSALYLYIGCFHMHTQVLNRMSSALPLLYWSMAHATLYAKSRNLKAFGHCILFVWIVYTVIQAGLYGSFLPPA 426
2 -92.600[R] KOG2647 Predicted Dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  22  2...................AKALESNSKSRKETILIKYAIFSRLLVLFLTILWRSLLQPYDTSAALNPEDSFPFLVANAASRSLENSVVWDSVYFLRITECGYEYEQTYAFLPLLPFFISLLSRTVGLRAVMVLSGFTVSNLAFIFAAIYLFRVSVIILKDTEASFRASIIFCFNPASIFYSSIYSESLYALFSIGGVYHLLSGTSNVGVLWFALSGCARSNGILNAGYICFQTMHRAYEALYQKRRAYLAMQVFIAGFLRCICICLPFVAFQAYGYYNICHGRPWCKGRIPLLYNFIQKILRGVGFLKYFQFKQLPNFLLASPILSLAVCSIMSYMKSRPEYLSADVFPFIVHLSFMVTTAFFIMHVQVATRFLSASPPLYWFASSLIGSPKHSK---WGYLIWSYCAAYILLGTLLFSNFYP.. 490
3 -20.100[O] COG4346 Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  8  154.........................................................................................GYKYPDEENIHKYLNTEH-----FLGKDIIALGMLIEDKPFYWRIPGIIEH----ALIVIIVTLVAYKITKSYLASSIAATFAALDPLLFATGVAMLDIHVAFFIALFMLFLALDRIRLSGIALGLAAATKLSGAFAFPILWFKILKEKDLKEYLISGLVLPMVSFLIPEITIIKAIGFIPWLEEFIASFSWHLSFKGEHPSEAPF-------WFVSLKPFPFHFDPDVYAVTDPILMIVFVFAVPYVSLRRKGLSEIFWMFWSIIAFFALQYILGGKTQFIFYATPLIPPGAVALGVISYEIIKWEYFERSLRIYLNYL------RSIAKPLKK.. 473
4 -15.400[MU] KOG2515 Mannosyltransferase  ali follow..  10  2...................PSKAPRKSLSVSFVWTFSILAVLRLTSASFRVIDDC-----------------------------EVYNYWEPLHYL-LYGYGLTWERSWFYIALHAVPGFLARGLGLSRLHVFYFIRGVLACFSAFCETNLILAVARNF-NRAVALHLTSVLFVNSGMWSASTFLPSSFAMNMVTLALSAQTKRTVKVVSFITIGAVIGWPFSAALSIPFILLELVDLKGRFRHLFCRWFKAIFVALLITGICITVDSLFYHRIQF----------------VKYNVLAKDIYGTEPWWYYFANLSLQHNIVLWFAMACGPLVLLAAFTNWINLDSFLDLSSVISPFYIWLFIFIIQPHKEERFMYPIYPVLCLAAAIGSSINETVRSKFPVRFVVLCVYAIIGCLSI........ 390
5 -14.400[G] KOG4123 Putative alpha 1,2 mannosyltransferase  ali follow..  10  2.................RLTTLWQNRSPGDRHLSTYFCFAAVRLLLVFVP----------------------------------LGYVHPDE-FFVEVMTGRLEHTRTWEFNNVLPFALLRIPWSF-GTYAYVVFPRLIYTLISFSNDYCLFRICRLYGLR---FEIRLLAMGSSWILLVFGTTFSNSLEMAMCSWLLCLVNLQHLMAMSTICVAGVFNRPTFLLFGAPMVFFWLLRGMGTRSITFRDFNLRIALFCLCALPALVLFIFCYYQHLTLGELHMMHLSIDNFVFTPWNFIKANLDSAQTASHGVHPCYVHLMVNMPMLFASLGAFAQLLLRFFRAEYQVLPRFQSIVSLMSGAIFVPLFFLSLPRFLLVTFPLILLHAPKLITGFSAKSKASGPYLLKIWYVSNVALTLFFGFIHQAG 478
6 -14.300[O] KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase  ali follow..  9  27.ESSSISVSEELSSADERDAEDFSKEKPAAQSSLLRLESVVMPVIFTALALFTRMYKIGINNHVV------------------------WDEAHFGKFGSY-YL---RHEFYPLGKMLVGLSGYLAGYNGSWDFLL-LFNASFSALCVPLAYFTAKAIGFSLPTVWLMTVLVLFENSYSTLGFILLDSMLLFFTVASFFSFVMFHLLITGISLGCTISVKMVGLFIITMVGIYTVIDLWTFLADKSMSWKTYINHWLARIFGLIIV................................................................................................................................................................ 295
7 -13.900[S] COG5305 Predicted membrane protein  ali follow..  10  49................................................................................................................PLYFVLVHLWMKLFPNQLVSLLAARSFPALLGAVSIPLTYILGRLAFRSSLVGQLAAGMMAVSPYAVYLGQHYT--LAMIWVIASLSCLVIWLIILWVGINALGIATHYFFTLTLCAEALVLIFLAWQQSTQAKTLVFFSPLWWRIYAVAAGTAVAGLILENRYRSSLTAWIQVQGIGLHLINPIFQAFAAWVTMIMLLPIESSQLAVVIASGLVMLIFAIWA--QTSLATQVFIGVVLGAIALFFILTYIFGVDITRGARYNFVYFPAVIILASLAVYWQTSKKAVMIIWLMGFVSAVTVICNLGYQKYYRP. 397
8 -13.800[O] KOG2292 Oligosaccharyltransferase, STT3 subunit  ali follow..  11  1MNRTPKMLNSKVAG-----------------YSSLITFAIL--LIAWLAGFSSRLF-----------------------VIRFESIIHEFDPWFNYRMVQNGLNWFDERAWYPITSGGIHWLLHVLNIPVHIRDICVFLAPIFSGLTSISTYLLTKELW-SAGAGLFAASFIAIVPGYISRSVA-NEGIAIFALQFTYFLWVRS--AAAALSYFYMVSAWGGYVFIINLIPLHVFVLLIMGRYSPRLLTSYSTFYILGLLFSMQIPF-------------------------------------VGFQPIRTSEHMAALGVFVLLMAVATLRHLQSVLSRNEFRKLFIVGGLLVGVGVFVAVVVLTMLGVVAPWSGRFILVCAFPVGVWYCIKQINDERVFVVLYAISAVYFAGVMVRLMLTLTPV 414
9 -13.700[O] COG1928 Dolichyl-phosphate-mannose--protein O-mannosyl transferase  ali follow..  10  19.IWRTPIVKEELEDADNFLKDDAELYDKVKNESAVSHLDTIVMPIIFTVLGMFTRMYKIGRNNHVV-----------------------WDEAHFGKFGSY-YL---RHEFYPLGKMLVGLSGYLAGYNGSWDFPSGLFQAMFSSLCVPLAYFTGRAIGFSRLSVWLFTILVIFENSYATLGFILLDSMLLFFTVSSYFCLAKFHLCLTGLNLGCAISVKMVGLFIISVVGIYTISELWNLLSDRSVSWKVYVNHWLARIFGLIIIPVCVF........................................................................................................................................................... 294
10 -13.300[O] COG4745 Predicted membrane-bound mannosyltransferase  ali follow..  8  13..........................................AAAVVAVTAAALLA-----------------------LWALGWRVAHQDADWTLQYMDLGAWQYRPIIHGPFLPHVNGVVFDVFGATD---FTMRLVVAVVGGLLPLTAWLYRTRL--SDVEVGALAVLLAANPVVLYYSFMRNDLLLAGFMFTAVGLFVRRYLYASAVPFALAFTTKENSLLYPLCWLGALALVTDDRMAVAGLAGSALTAAVIVVSFYAPKPDLYRLFEQPGRAPAVLEAATIGTYHEFADLWASTSTVAHSYVAFLSHDLSVLVACGTVVSVAAVVGYLANRYATETPRPLVSF-AFYWGVFSVLGYPAVVDIAAAWTAVNALVPLAIPAAVGVGAAAGDTAAVRLAVTVLVVSAAGMGAVAAETTYAHPQ 416
11 -13.200[R] KOG2552 Major facilitator superfamily permease - Cdc91p  ali follow..  9  2..............KEEKKDDGVMAEEKPYMFWIWTLASTIFRLFLIFSPANINLSSRPEVSTPHTSLRRLA------------------EGYWLKQSSLSPYA--SMYHGSPLLLSILGPLTVQSDKFVVAGSKGNRVIICADLLSALLLRAIGQKLQKSYRCGDIAALVYLWNPFTILSCVGLSSPIENLAVIVSLYGAVTRRVPLAAFGLIMATHLSLYSAPLVFPLIFLLEKLTPTTQLPFSWRTVLHFVFWVLVWSSYVLVLCSLSLKQYGGL----------------EEMFKRTY-NIGVFWYFFAEAFEFSRNYLLIIFNLYILLTSIPSLMFRLKHRPCFLAFAYLAFTSIL-----------KSYPSVGDAALYLSLWALFVNELTDMEYSFFIFCGYIGFSLLSPVMHANFY... 435
12 -13.100[R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation  ali follow..  11  2.............ANSATITSKKGVKSHQKDWKIPLKVLIL--ICIAVASVSSRLFSVIRYES-----------------------IHEFDPWFNFRLVEQGLNWFDERSWYPVTSGIIFKVLHLLRINVNIRDVCVLLAPAFSGITAIATYYLARELK-SDACGLLAAAFMGIAPGYTSRSVA-NEAIAITLLMSTFALWIKAWGACTGLLYFYMVTAWGGYVFITNMIPLHVFVLLLMGRYTSKLYIAYTTYYVIGTLASMQVPF-------------------------------------VGFQPVSTSEHMSALGVFGLLQLFAFYNYVKGLVSSKQFQILIRFALVCLVGLATVVLFALSSTGVIAPWTGRFFLIWLLPVGVYLCFKELRNEHVFIIIYSVLGTYFCGVMVRLVLTLTPC 419
13 -12.800[S] COG5650 Predicted integral membrane protein  ali follow..  7  1MDQKLDQQKVDRVSPGDSEPVARDFINATQRFWTPLRVLITTSLVFLAMGFLTKA--------------------IQGSRGTDGVVSLNWSG--YNDIVPLYGGRGIDAPGFP-YPVLGGIFYPVVDVIPFHTLPESGLYFIVTALALAFFWVLVIRMMVETGNRVWDTVLVAASPLVAVHAFTNWDTPAIAAVIGAMLAVKRGNPLVAGVLIGAGTAFKLWPLYLLGAYLVLAVKNKNLKPFITMAAAAAVTWLVVNVPVMIAYPKAWNEFLRLNRERGAE---------------WTTIYQVIDRNLPINLNDPVLLNVLSFGLFGASCVAILILGLKVQRTPR-----VAELAFLIVAAFLLFNKVWSPQYSLWLVPLAVLAF........................................ 392
14 -12.500[S] COG5617 Predicted integral membrane protein  ali follow..  11  5..........................................LYYLTLATISVIEYIPLYLAPSPPALQINGNGHLFKVHKLMTSGWKPWIEDWY-----AGYPF---LRFYPPLSYLTAGVLGKVLGSDTKGYAATLM--LTSFLGALALHHYLKST---GREPCISPLIFLLFPTVSYIEGNFPRANLAPLFLLSLYWLREKRLIASALGISIVALTHYSILPLLIITGILILWDDLRTMTALGNGIKVLGAVIGLTSFWYVPFL-------------------------FDKKWVEFWNISENKALFKSFSLNPTLLKSPFGILLILLLLIFAIFAIKNLVDRKKVILAGLYLYLSLGFYSLLSIVPPYRWFDLEALIIPLLIGESLKRVQRKSMVALVIIPFTVLAFMNV............ 356
15 -12.300[OKIT] KOG2642 Alpha-1,2 glucosyltransferase/transcriptional activator  ali follow..  11  49..........................................................................................DEIFHISYCSGNYSWNPLITTPPALYVISMPLCGGNERYANSILLFFAIPAFCRFRRMFVRVRIPTLKIYLQQDVWLTASIVGMLPILISSSILYTDLLSLTSVIWGFSI---GNPIASAFLFLISILTRQTNIIWAAIYAFSVIASRIDKSRSKMENLKIIISTAFSLWPFITLAIGFAMF-----------------------------YFNDFQI--FHVAQFFYMVAFCAAHTWTQIIPNLLSHLRHLTDMKSLVLQAVVAVLVYYYSYDHPYLLADNRHFTTLAPLYVFSLRFMTTSTPSVHIFHKILFIIASLLYYIIPYVLWRLSTVNN 398
16 -12.200[MU] KOG2516 Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family)  ali follow..  9  8...........................................TVLLTVISFHLIQAPFTKVEESFNIQAIHDILTYSVFDI------QYDHLKFPGVVPRTFVGAVIIAML-DVQLVVRGIVGLTNGLSFIYLKNCLQDMFDEITEKKKEENEDKDIYIYDSAGTWFLLFLIGSFHLMFYSTTLPNFVMTLPLTNVAWVLLGRYNAAIFLSALVAIVFRLEVSALSAGIALFSVIFKKISLFDAIKFGIFGLGLGSAISITVDSYF------------------WQEWCLPFLFNVVAASKWGVEPVTAYFTHYLRMMFMPPTVLLLNYFGY--------KLAPAKLKIVSLASLFHIIVLSFQPHKEW--RFIIYAVPSIMLLGATGAAHENMKVKKITNVLCLAILPLSIMTSFFISMAF... 383
17 -11.700[G] KOG3893 Mannosyltransferase  ali follow..  8  410......KYNSRENMITKLRESSLYLLYAPTDAFLLLLLGLLMRLVLLNYGIWHDRRSALKFTD--------------------IDYFVFSDASKYVSIGMSPYM-RDTYRYTPMLAILLLPTQYGFP------SWGKYLFSISDLIAGWLMIKLLSRR-ISYKRSLIYSSFWILNPFVAIIST--CEAILGILSIALLYLIEKKSVWLASLILGFSVHFKIYPFMYGIAFLVYFSKPKKGSTFMEKFLSLLSINQLKIVVGSLFMFTICNLLMYYLYGSPFLEHTYLYHFGRTDHRHNFSLHHLNLYYESSFGAKASSLFAFLPQLSLCMLIPLVFGKKNLPGTLFAQTFAFVFMWYLVFLPLVLPNSKLLSKKGLICQLLWLISAYNLEMLGKSVFIPLWLSGLLFFFFNVYELKIILDS..... 814
18 -11.500[S] COG3463 Predicted membrane protein  ali follow..  12  8................................KLLVIIFIAYTFIIFKTCLVLYENFSYKS----------------------------LDLGIFSQSTLNGKFMYNTVEFQPILLLLLPVYAIMPSPVVLLLIQAIFLA-----LSATLALLIACEEL-NHREAILVASLYIFNSSGIALFEFHPVSLAVPLFFIAYMLLKRGKMKLFYLTSVLILLTKEDSFLGVVSLSLWKILMDGLNPESFRKNRGLILLSIASMMYGIIVIKVVIPHLGMGYIYESLYSEFELTRRKLLYFIV---------FGFLTFLSSKGLVSVALPWLESMLSSRDTQTMIGFHYPYMLLPLSYLVAIEGFKKSKKVAVSLIVAGILTSMATIPITF........................................ 340
19 -11.400[MO] KOG1771 GPI-alpha-mannosyltransferase III (GPI10/PIG-B) involved in glycosylphosphatidylinositol anchor biosynthesis  ali follow..  10  3................................IWFWLAILVFRWWNALW------------VKTFFQPDEFYQSLEVAHHFIFRYGFLTWE-----------WTSAIRSALHPLIFAALYRVLQVLKSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFAYSSLLGFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVNII-RILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPFVLL---------TMDLQTAGTILCVFFPYSLIGHKEL--RFVYPISPILLTLAGKFFSSFSSWKRA--ARFFFLIGLGHALVITFLCRF.... 376
20 -10.900[M] COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family  ali follow..  8  27......................................................................................LWQPDETRYAEISRLGLRYFEK----P--IAGYWINSIGQWLFGANNFGVRAGVIFATLLTAALVTWFTLRLWRDKRLALLATVIYLSLFIVYAIGYAVLDPFIAFWLVAGMCSFKSAGFLLLGITCGMGVMTKG-ALAVPVLSVLPWVATQKRWKDLFIYGWLAVISCVLTVLPWGLAIAQ---------------------------NFWHYFFWVEHIQRFALDDA---YVPVIIAGSLPWLGLLPGALYTGWKNRKHSATVYLLSWTIMPLLFFSVAKGKLPTYILCFASLAMLMAHYALLAAKNNPLALRINGWINIAFGVTGIIATFV...... 362
21 -10.600[S] COG4713 Predicted membrane protein  ali follow..  10  118............................................................................................................IVYIP---IGINLAKIFRASALYMMYFGRIANLICWTIIVFFSVKLI-------PFKKNLMAFLALTPMNLYQAASLSDAMTNSMAFLSIALVLRRQIVTMIIAFTLLAFSKRIYFVMCILFFIIPIKKFNSKKDYIGTFVIMLGACLMSLVTVSVISKILAIKVSAGSYTPGQMEFVLSHPITYIHILLRTFH--IGVFGWLDT-RLPLNLYLFYGVALVLIALFEHTLIEKNKDRIIMFIVFIINVGLIMSALYVSWTPK--RYFIPIIPLLGCFIGVKANKSRNVYSKVVLAISTFTILTYSV-LQLLLRFY... 451
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 1 0 5   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;