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Query: [S] COG5650 Predicted integral membrane protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDQKLDQQKVDRVSPGDSEPVARDFINAIGGRFGRFAQVGTQRFWTPLRVLITTSLVFLAMGFLTKANCIQGSRGTDGVVSLNWSGSRQYTSACYNDIVPLYGGRGIDAPGFPYAFSWQEGDLTRYMEYPVLGGIFQWICGIITRFLYPVVDVIPFHTLPESGLYFIVTALALAFFWVLVIRMMVELTGNRVWDTVLVAASPLVAVHAFTNWDTPAIAAVIGAMLAVKRGNPLVAGVLIGAGTAFKLWPLYLLGAYLVLAVKNKNLKPFITMAAAAAVTWLVVNVPVMIAYPKAWNEFLRLNRERGAEWTTIYQVIDRNLPINLNDPVLLNVLSFGLFGASCVAILILGLKVQRTPRVAELAFLIVAAFLLFNKVWSPQYSLWLVPLAVLAFPQWKVLFPWMVTDAMVWPILMWHMLGTDNKGLPHEMLDLIVISRDAFIVVMIVGVIRQMLGRRADPVMDAHAGRDLLAGPFGAGERRKALKEVSLast
1 -143.000[S] COG5650 Predicted integral membrane protein  ali  100  1MDQKLDQQKVDRVSPGDSEPVARDFINAIGGRFGRFAQVGTQRFWTPLRVLITTSLVFLAMGFLTKANCIQGSRGTDGVVSLNWSGSRQYTSACYNDIVPLYGGRGIDAPGFPYAFSWQEGDLTRYMEYPVLGGIFQWICGIITRFLYPVVDVIPFHTLPESGLYFIVTALALAFFWVLVIRMMVELTGNRVWDTVLVAASPLVAVHAFTNWDTPAIAAVIGAMLAVKRGNPLVAGVLIGAGTAFKLWPLYLLGAYLVLAVKNKNLKPFITMAAAAAVTWLVVNVPVMIAYPKAWNEFLRLNRERGAEWTTIYQVIDRNLPINLNDPVLLNVLSFGLFGASCVAILILGLKVQRTPRVAELAFLIVAAFLLFNKVWSPQYSLWLVPLAVLAFPQWKVLFPWMVTDAMVWPILMWHMLGTDNKGLPHEMLDLIVISRDAFIVVMIVGVIRQMLGRRADPVMDAHAGRDLLAGPFGAGERRKALKEVS 486
2 -35.800[G] KOG3893 Mannosyltransferase  ali follow..  13  434.............................................DAFLLLLLGLLMRLVLLNYGI--------------------HDRRSALKFTDIDYFVFSDASK-----YVSIGMSPYMRDTYRYTPMLAILLLPTQYGFPSWGK--------------YLFSISDLIAGWLMIKLLSRRISYKRSLIYSSFWILNPFVAIISTRGNCEAILGILSIALLYLIEKKSVWLASLILGFSVHFKIYPFMYGIAFLVYFSKPKKGSTFMEKFLSLLSINQLKIVVGSLFMFTICNLLMYYLYGSPFLEHTYLYHFGHHLNLYYESSFGAKASSLFAFLPQLSLCMLIPLVFGK-KNLPGTLFAQTFAFVTFNKVCTSQYFMWYLVFLPLVLPNSKLLSKKGLICLSLWIIISAYNLEMLGKSVFIPLW-LSGLLFFFFNVYELKIILDSL................................... 815
3 -25.500[R] KOG2552 Major facilitator superfamily permease - Cdc91p  ali follow..  8  1............................MKEEKKDDGVMAEEKPYMFWIWTLASTIFRLFLIFSPANINL-----------------SSRPEVSTPHTSLRRLAEGYW-----LKQSSLSPYAGSMYHGSPLLLSILGPLTVQSD-------KFVVAGSKGNRVIICADLLSALLLRAIGQKLQKSYRMNLRAALVYLWNPFTILSCVGLSTSPIENLAVIVSLYGAVTRRVPLAAFGLIMATHLSLYSAPLVFPLIFLLGYGLDAPPFWVLVWSSYVLVLCSLSLKQYGGLEEMFKRFILRIEDLSPNIGVFWYFFA----EAFEFSRNYLLIIFNLYILLTSIPSLMFRLKHRPCF--LAFAYLAFTSILKSYPSVGDAALYLSLWALFVNEYSFFIFCGYIGFSLLSPVMHNFWIWRGTG-NANFYFGNAMGYACFQFMFVEKSVNAMLNHDQA............................. 463
4 -25.200[O] COG4346 Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  13  169..............................................................................................................................TEHPFLGKDIIALGMLIEDK-----------PFYWRIPGIIEHALIVIIVTLVAYKITKSYLASSIAATFAALDPLLFATGIVAMLDIHVAFFIALFMLFLALDRIRLSGIALGLAAATKLSGAFAFPILWFKILKEKDLKEYLISGLVLPMVSFLIPEITIIKA-EEFIASFSWHLSFKGEH---WFVSLKPFPFHFDPDVYAVTDPILMISMIVFVFAVPYVSLRRKGLFWSIIAFFALQYILGGKTQFIFYATPLIPPGAVAL.............................................................................................. 440
5 -19.500[GE] KOG2575 Glucosyltransferase - Alg6p  ali follow..  12  33.....................................LTHKGTTTSFLCISLFALLIRSAVTMYPYSGAGIPPKFGDFEAQRHW------MEITTNLPVIDWYRNGTYNDLTYW-----------GLDYPPLTAYQSYIHGIFLRFFSSRGHESYLGKLLMRWTVLSSDAFIFFPAALFFVLVYHRNRTRGHIAMILLNPCLILIDHGHFQYNCISLGLTVGAIAAVLCESEVLTCVLFSLALSHKQMSAYFAPAFFSHLLGKSPILSVIKLGIAVIVTFVIFWWPYVHS-LMVLSRLAPFERG-EDYVANFWCTTSILWKNLFTTQSLKSISLAATILASLPSMVQQILSPSNEGFLYGLLNSSMAFYLFSFQVHEKSILMPFLSATLLALKLPDHFSHLTYYALFSMFPLL......................................................................... 417
6 -16.600[G] KOG2762 Mannosyltransferase  ali follow..  10  39........................................DCRANLIVMPLLILFESMLCKIIIKKVA--------------------------YTEIDYKAYMEQIEDGMLDYS---QVSGGTGPLVYPAGHVLIYKMMYWLTEGMDHVERGQVFF-------------RYLYLLTLALQMACYYLLHLPPWCVVLACLSKRLHSIYVLRLDCFTTLFMVVTVLGAIKSLALVISATYSMAVSIKMNALLYFPMISLFILNDANVILTLLDLVAMIAWQVAVAVPFLRSFPQQYLH--AFNFGRKFMYQ--WSINWQMMDEEAFNDKRFHLALLISHLIALTTLFVTRYPRIPAKTIPFVLIASNFIGVLFSRSLHYQFLSWYHWTLPILIFWSGMPFFVGPIWYVLHEWCWNSYPPNSQASTLLLALNTVLLL................................................... 429
7 -16.600[M] COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family  ali follow..  12  8.................................................IGLFAFIACYYLLPISTRLLWQPDETR------------------YAEISREMLASG----IVPHLLG------LRYFEKPIAGYWINSIGQWLFGA-----------NFGVRAGVIFATLLTAALVTWFTLRLWRDKRLALLATVIYLSLFIVYAIGTYAVLDPFIAFWLVAGMCSFKSAGFLLLGITCGMGVMTKGFLALAVPSVLPWVATQKRWKDLFIYGWLAVISCVLTVLPWGLAEPNFWHYFFRFALDDAQHRAPFWYYVPVIIAGSL------------LGLLPGALYTGWKNRKHSATVYLLSWTIMPLLFFSVAKGKLPTYILSCFASLAMLMAHY........................................................................................... 330
8 -15.000[K] KOG2576 Glucosyltransferase - Alg8p  ali follow..  12  3..................................................KLSMLYNAAIASTFVKVFLFPSYRSTDFEVHRNWLAITHSLPI-YKSSISEW-----------------------TLDYPPFFAYMECVLSWIAYFFGNYVSPSTVVFQRGSVIVLELVLLFALREYVLSSNVKDQRNALLTAIDIFLSPGLLIIDHIHFQYNGFLFGLLLWSIVLAKPEKMLLSAAIFSALICFKHIFLYVAPAYFVYLLRVPQFLNILKLGSTVISIFLLAFGPWIYMKQIPQLLSRLFPFSRGLCHANFWALYSFVSSFAVLPNIPPALTFYICLGLQITVLIKLFIKPTWRVFVGAVTLCGWISFLFGWHVHEKAILMVILPFSILSLIDRRYLEAFRPLAVSGYLSLL......................................................................... 399
9 -14.300[O] KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase  ali follow..  10  19.QENTLRQRESSSISVSEELSSADERDAEDFSKEKPAAQSSLLRLESVVMPVIFTALALFTRMYK----------------IGINNHVVWDEAHFGKFGSYYLRHEFYHDV-----------------HPPLGKMLVGLSGYLAGDFLLEIYPDYLDYVKMRLFNASFSALCVPLAYFTAKAIGFSLPTVWLMTVLVLFENSYSTLGRFILLDSMLLFFTVASFFSFVMFHLLITGISLGCTISVKMVGLFIITMVGIYTVKSMSWKTYINHWLARIFGLIIVPFCIFLLCFKIHFDLLSHSGTGDANMPSLFQ............................................................................................................................................................................ 326
10 -14.000[O] COG1928 Dolichyl-phosphate-mannose--protein O-mannosyl transferase  ali follow..  7  12.KSTDDDLIWRTPIVKEELEDADNFLKDDAELYDKVKNESAVSHLDTIVMPIIFTVLGMFTRMYK----------------IGRNNHVVWDEAHFGKFGSYYLRHEFYHDV-----------------HPPLGKMLVGLSGYLAGYNGSWDFPSGIDYVKMRLFQAMFSSLCVPLAYFTGRAIGFSRLSVWLFTILVIFENSYATLGKFILLDSMLLFFTVSSYFCLAKFHLCLTGLNLGCAISVKMVGLFIISVVGIYTIRSVSWKVYVNHWLARIFGLIIIPVCVFLLCFKIHFDLLSNSGPGDSTMPSLFQ............................................................................................................................................................................ 320
11 -13.100[O] KOG2292 Oligosaccharyltransferase, STT3 subunit  ali follow..  9  19.................................................ITFAILLIAWLAGFSSRLFAVIRFESI--------HEFDPWFNYRATAYM-------VQNGWYNFLN-------DERAWYPVYPGLMITSGGIHW--LLHVLNIPVHIRDICVFLAPIFSGLTSISTYLLTKELWSAGAG--LFAASFIAIVPGYIVAGSYDNEGIAIFALQFTYFLWVRSWSAAAALSYFYMVSAVFIINLIPLHVFVLLIMGRYSPRLLTSYSTFYILGLLFSMQIPFVGFQPIRTSEHMAALGVFVLLMAVATLRHLQSVLSRNEFRKLFIVGGLLVGVGVFVAVVVLTMLGVVAPILVCAFPVGVWYCIKQINDERVFVYAISAVYFAGVMVRLMLTLTPVVCMLAGVAFSGLLD.................................................................... 428
12 -12.800[S] COG5542 Predicted integral membrane protein  ali follow..  7  1MKLNESAMKNAEKKSNSYLAIRMTRSGY------------NYFKGICVCTFLLSTILYLGIAVIMSH--ESNIFRTLFISWIRWDA--------FVDMAVNGSLFEQEWAFSS---------------WPKIISFL-----------AFRSKDVVLLGIVSCFASIFFHAIACYALYLLTKSIFSN-QKMTAYTVIFYCFSPSGIYMSVGYTESLFAAFSFLGLLLFIKKQQYPAAFLWSLATLIRSNGIFWCIFFGMPAIGTLKISLERLQLTFMQVSQLVGYGTKCLIILVPFFYNQYLGFKLFCPVQEKYWNVGFLRYWTLNNIPNFLFALLSIIPILFALFYSISGSTLHSFRLVLSALYLYIGCFHMHTQVLNRMSSALPLLYWSMA.............................................................................................. 386
13 -12.500[S] COG4713 Predicted membrane protein  ali follow..  10  110...........................................................................................................................RSATIYSDIVYIPQSIGINLAKIFR-----------ASALYMMYFGRIANLICWTIIVFFSVKLIPFKKNLMAFLALTPMNLQAASLSADAMTNSMAFLSIALVLRRQIVTMIIAFTLLAFSKRYFVMCILFFIIPIKKFNSKKDYIGTFVIMLGACLMSQMEFVLSHPITYIHILL----RTFHFKMSFYAISFIGVFGWLDTRLPLNLYLFYGVALVLIALFEHTLIEKNKDIINVGLIMSALYVSWTPKIQGRYFIPIIPLLGCFIGVKANKSRNVYSKVVLAISTFTILT----------YSVLQLLLRFYGIRIL........................................... 456
14 -12.400[G] KOG4123 Putative alpha 1,2 mannosyltransferase  ali follow..  10  15.............................................RHLSTYFCFAAVRLLLVFVPQL---------------GYVHPDEF----FQSVEVMTGDHFRLEHTRTW--EFNNSLPVRSIVLPFALLRIPWSFYEFVAECLKAWWQLELLGTYAYVVFPRLIYTLISFSNDYCLFRICRLYGLRFEIRLLAMGSSWILLVFGTR-NSLEMAMCSWLLCLVNLQHLMAMSTICVAGVFNRTFLLFGAPMVFFWLLRSITFRDFNLRIALFCLCALPALVLFIFCDSLYYQHLTLGELHMMHLSIDKANLDSAQTASHGVHPCYVHLMVNMPMLFNVLALASLGQVLPRFQSIVSLMSGAIFVPLFFLSLINHQEPRFLLPVTFPLI.............................................................................................. 415
15 -12.300[R] KOG2647 Predicted Dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  8  7....................................SNSKSRKETILIKYAIFSRLLVLFLTIL--WRSLLQPYDTSAALNVVW------------D--SVYFLRITECG---YEYEQTYAF------LPLLPFFISLLSRTVFAPLVPLIGLRAVMVLSGFTVSNLAFIFAAIYLFRVSVIILKDTEASFRASIIFCFNPASIFYSSIYS-ESLYALFSIGGVYHLLSGTSNVGVLWFALSGCARSNGILNAGYICFQTMHRRRAYLAMQVFIAGFLRCICICLPFVAFQAYGYYNI............................................................................................................................................................................................ 276
16 -12.200[MU] KOG2515 Mannosyltransferase  ali follow..  10  2...............................PSKAPRKSLSVSFVWTFSILAVLRLTSASFRVIDDC--------------------DEVYNY-WEPLHYLLYGYGLQ-----------------TWEYSPEYAIRSWFYIALHAVPGFLARGLGLSRLHVFYFIRGVLACFSAFCETNLILAVARNFNRAVALHLTSVLFVNSGMWSAST-SSFAMNMVTLALSAQLSPPSKVVSFITIGAVIGWPFSAALSIPFILLELLKGRFRHLFCRWFKAIFVALLITGICITVDSLFYWNIVKYNVLAKDGRGPDIYGTEPWWYYFANLSLQHNIVLWFAMACGPLVLLAAFTNWINLDSFLDLSSVISPFYIWLF-IFI-RFMYPIYPVLCLA----------AAIGLDMSLKLMIQILSSINETVRSKFPVRFVVLCVYAIIGCLSIARILAIQNYNAPMI.......................... 404
17 -11.700[O] COG4745 Predicted membrane-bound mannosyltransferase  ali follow..  12  15.................................................AVVAVTAAALLARLWA-------------------------WRVAHQDRVADWTLQYMDLGAWQY----------RPIIHGPFLPHVNGVVFDVFGAT----------DFTMRLVVAVVGGLLPLTAWLYRTRL----DVEVGALAVLLAANPVVLYYSFMRNDLLLAGFMFTAVGLFVRRYLYASAVPFALAFTTKENSLLYPLCWLGALA-RHRAWRAKAALAGSALTAAVIVVSFYAPKPDLYRLFEQPGRAPAVLEAATIGTYHEFADLWASTSTVAHACGTVVSVAAVVGYLANRYATETPRPLVSFAFYWGVFSVLGYPAVVDIAAAWLVPLAIPA---------------AVGVGAVVRYGRRGAAAGDTAAVRLAVTVLVVSAAGMGAVAAETTYAHPQSPVQYAQPGGT................... 431
18 -11.600[R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation  ali follow..  6  24.................................................LKVLILICIAVASVSSRLFSVIRYES---------HEFDPWFNFRASKIL-------VEQGFYNFLN-------DERSWYP--LYPGLMVTSGIIFKVLHLLRINVNIRDVCVLLAPAFSGITAIATYYLARELKSDACG--LLAAAFMGIAPGYTVAGSYDNEAIAITLLMSTFALWIKAWGACTGLLYFYMVTYVFITNMIPLHVFVLLLMGRYTSKLYIAYTTYYVIGTLASMQVPFVGFQPVSTSEHMSALGVFGLLQLFAFYNYVKGLVSSKQFQILIRFALVCLVGLATVVLFALSSTGVIAPFLIWLLPVGVYLCFKELRNEHVFIYSVLGTYFCGVMVRLVLTLTPCVCIAAAVAISTLLDT................................................................... 434
19 -11.300[S] COG3463 Predicted membrane protein  ali follow..  12  13.................................................IFIAYTFIIFKTCLVLYENFSYKSLDLG------------FSQSLYS----------TLNGKFMYNTVEAQLYSAPNHHFQPILLLLLPVYAIMPS------------PVVLLLIQAIFLALSATLALLIACEELNHREAILVASLYIFNSSLLGIALFEFHPVSLAVPLFFIAYMLLKRGKMKLFYLTSVLILLTKEDSFLGVVSLSLWKILMDGLNPESFRKNRGLILLSIASMMYGIIVIKVVIPHLGMGYIYESLYSEF--------------LTRRKLLYFIVFNASFGFLTFL------SSKGLVSVALPWLESMLSSRMIGFHYPYMLLPLSYLVA.............................................................................................. 310
20 -11.200[S] COG5617 Predicted integral membrane protein  ali follow..  8  8.................................................LTLATISVIEYIPLYLAPS---------------ALQINGNGHL-------FKVHKLMTSGWKPWIEDWYAGYPFLRF-YPPLSYLTAGVLGKVL------------GSDTKGYAATLMLTSFLGALALHHYLKSTGREPCISPLIFLLFPWHLTVSYIEGNFRANAIHLAPLFLLSLYW--LGISIVALTHYSILPLLIITGILILWDDLRTMTALGNGIKVLGAVIGLTSFWYVPFLF----------------DKKWVEFWNISENKALFKSFSLNPTLLKSPFGILLILLLLIFAIFAIKNLVDRKKVILAGLYLYLSLGFYSP--TTWLYSFPLLSIVPPYRWFDLEALIIPLLIGESLKRVQRKSMVALVIIPFTVLAFMNVPKI.............................................. 359
21 -10.700[MU] KOG2516 Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family)  ali follow..  10  9.................................................VLLTVISFHLIQAPFTKVEESFNIQAIHDILTYSVFDISQYDHLKFPGVVPRTF---VGAVIIAMLSRPYLYLSSIQTSRPTSIDVQLVVRGIVG------LTNGLSFIYLKNCLQDMFDEITEKKKEENEDKDIYIYDSAGTWFLLFLIGSFHLMFYSTRTLNFVMTLPLTNVAWVLLGRYNAAIFLSALVAIVFRLEVSALSAGIALFSVIFKKISLFDAIKFGIFGLGLGSAISITVDS----VDGFLFNVVAGYASK--AYFTHYL-------------MMFMPPTVLLLNYFGYKLAPAKLKIVSLASLFHIIVLFQPHKEW--RFIIYAVPSIMLLG.............................................................................................. 344
22 -10.300[OKIT] KOG2642 Alpha-1,2 glucosyltransferase/transcriptional activator  ali follow..  8  1............................MTKSKPPRISLPFAAISRKSDFLLGASFSCIHVLLTTIVYHYVPEP--------------------YMDIFHITQTRSYCSGNYSW---------NPLITTPP----LYVISMPLCGGNERYANSILLFFAIPAFCRFRRMFVRVRIPTLKIYLKNTDLQQDVWLTASIVGMLPILISSSILFYDLLSLTSVIWGFSI---GNPIASAFLFLISILTRQTNIIWAAIYAFSVIKMENLKIIISTAFSLWITLAIGFAMFIYFNDFQIVLGDAKAHQPKFHVAQFFYMVAFCAAHTW---ANPTMRTTLAPLYVFSLRFMTTSTPSVHIFHKILFIIASLLVLVPAHLFEMRYYI--IPYVLWRLRKSLLFLEIISQAVIFAANEFVQK...................................................................... 423
23 -9.440[MO] KOG1771 GPI-alpha-mannosyltransferase III (GPI10/PIG-B) involved in glycosylphosphatidylinositol anchor biosynthesis  ali follow..  6  4................................................WFWLAILVFRWWNALWVKT----------------FFQPDEF----YQSLEVAHH---FRYGFLTWEWTSAIR----SALHPLIFAALYRVLQVLK------LDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFAYSSLLGFISVAAFACFIR-NILVWIFPLLFWNKNPQTYALGYGRLFGIFVLCVSLFLVNIIADRILYGRFV---------SFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPFVLL----TMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLA.............................................................................................. 342
24 -9.310[S] COG4485 Predicted membrane protein  ali follow..  7  13.................................................ISFIIPVVIMSGVYLSQS-----WNSDNSPLLGDGFHQ-VALRNILHGNSNLFYTFTSGLGLNFY----------ALSSYSFLAPLVYFFDL----------------TNMPDAIYLTTLLKFGLIGLSTFFSLNKLFQSIPQILKLALSTSYALMSFTVSQLDVFILILIITGL-LITEKKLLLYFTSLSILFIQNYY-MTVLFLIFWYLCQKSSVLDFIVISFLAGMASLIMTLPTLFDLQTHGEKLTEVTKFQTESSWYLDLFAKQFIGSFDTTKYGAIPMIFVGLFPFILTILFFTLKSIKFHVKLIYVIFFAFLIASFDLFWQLHRYAWIFSTLLIYTAKVWNFLVSLFLVVAGFLATIYLKSHYSFLTDLNILLTLEFLVVYSLLLLA........................................... 425
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.