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Query: [OR] KOG0010 Ubiquitin-like protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAESGESGGPPGSQDSAAGAEGAGAPAAAASAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDTLSQHGIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSSLGLNTTNFSELQSQMQRQLLSNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGTSGQSTTAPNLVPGVGASMFNTPGMQSLLQQITENPQLMQNMLSAPYMRSMMQSLSQNPDLAAQMMLNNPLFAGNPQLQEQMRQQLPTFLQQMQNPDTLSAMSNPRAMQALLQIQQGLQTLATEAPGLIPGFTPGLGALGSTGGSSGTNGSNATPSENTSPTAGTTEPGHQQFIQQMLQALAGVNPQLQNPEVRFQQQLEQLSAMGFLNREANLQALIATGGDINAAIERLLGSQPSLast
1 -171.000[OR] KOG0010 Ubiquitin-like protein  ali  100  1MAESGESGGPPGSQDSAAGAEGAGAPAAAASAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDTLSQHGIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSSLGLNTTNFSELQSQMQRQLLSNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGTSGQSTTAPNLVPGVGASMFNTPGMQSLLQQITENPQLMQNMLSAPYMRSMMQSLSQNPDLAAQMMLNNPLFAGNPQLQEQMRQQLPTFLQQMQNPDTLSAMSNPRAMQALLQIQQGLQTLATEAPGLIPGFTPGLGALGSTGGSSGTNGSNATPSENTSPTAGTTEPGHQQFIQQMLQALAGVNPQLQNPEVRFQQQLEQLSAMGFLNREANLQALIATGGDINAAIERLLGSQPS 589
2 -46.200[L] KOG0011 Nucleotide excision repair factor NEF2, RAD23 component  ali follow..  16  2...................................AVTITLKTLQQQFKIRMEPDETVKVLKEKIEAEKGFPVAGQKLIYAGKILSDDVPIRDYRIDEKNFVVVMVTKTKAGQGTSAPPEASPTAAPESSTSFPPAPTSGMSHPPPAAREDKSPSEESAPTTSPESVSGSVPSSGSSGREEDAA----------------------STLVTGSEYETMLTEIMSMG---ERERVVAALRASYNNPHRAVEYLLT---------------------------------------------------------------------------------------------------------GIPGSPEPEHGSVQESQVSEQPATEAAGENPLEFLRDQPQFQNMRQVIQQNPALLPALLQQLGQ-------------------------------ENPQLLQQISRHQEQFIQMLNEPPGELADISDVEGEVGAIGE-------------------------------------EAPQMNYIQVTPQEKEAIERLKALGF-PESLVIQAYFACEKNENLAANFLLSQ... 358
3 -42.300[L] KOG0012 DNA damage inducible protein  ali follow..  16  1....................................MKITVTTSDDKFCLDVAQDLELENLKALCAMEIGAEVSQIAVIFNGRELSSDQTLQQCGVGDGDFIMLERRRSANRPVGGNPAISTLDFSNIAVPGTSSGGSPPSRRV----------------------------QQQGVQQPQFNNLTDIPTTDEFNVNFDDDPETVRQMFLSSPELSLLRQYNPSLAEAIDSGDKEKFARLLREH---ITERKRRNEHRMRMLNADPFDEETQRLIAEEIKQKNIQDNMAAAIEYNPEIFGTVTMLYINCKVNGIPVKAFVDSGAQTTIMSKDCAER-----------------------------------------------------------------HVNRLIDTRWNGVAKGVGTQPILGRIHMVQLQIENDHLTSSFTVLGQQPMDMLLGLDMLKRLQRNLLIIGTTGTTTPFLPESELPVSARLTGNSEDSMEQEAISNAIEQSKRESGGA---------------GGGPNTISPQERFTEQDVTDLMALGY-PRSDVLTVLRLCGGNKQAARSVLLHRNDA 451
4 -31.700[O] KOG4583 Membrane-associated ER protein involved in stress response (contains ubiquitin-like domain)  ali follow..  17  1MEENAAPP--------AAATAAGCDAATRQKNPETSVRLLIKSSNQQYEVDSDLCWTVQRLKKHLSLIYKPLIQDQKLIYSGKLLDDSQKISEVVYQQHHIFHLVCASKQVIRPAAKAPTVPQKDAVPAGPEVTGNANELRQRHAP........................................................................................................................................................................................................................................................................................................................................................................................................................................................... 149
5 -28.600[T] KOG4361 BCL2-associated athanogene-like proteins and related BAG family chaperone regulators  ali follow..  12  1MTNGGRGSGGGGGGGGRESGG-NPDLDPVGPPPPPMIRVRIKYGAVYHEINISPQASFGELKKMLTGPTGIHHQDQKLMYKDKERDSKAFLDVSGVKDKSKMVLIEDPLSQEKRFLEMRKIAKTEKASKAISD........................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 147
6 -28.300[J] KOG0004 Ubiquitin/40S ribosomal protein S27a fusion  ali follow..  36  1....................................MQIFVKTLTGKITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLR.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 72
7 -25.900[J] KOG0003 Ubiquitin/60s ribosomal protein L40 fusion  ali follow..  36  1....................................MQIFVKTLTGKITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLR.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 72
8 -24.100[DO] KOG0005 Ubiquitin-like protein  ali follow..  29  1....................................MLIKVKTLTGKIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLA.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 72
9 -23.500[O] COG5272 Ubiquitin  ali follow..  38  1....................................MQIFVKTLTGKITLEVEPSDSIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLR.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 72
10 -23.200[O] KOG3493 Ubiquitin-like protein  ali follow..  22  1...................................MIEITCNDLGKKVRVKCNPDDTIGDLKKLIAAQTGTKHEKIVLKKWYTIFKDPIRLSDYEIHDGMNLELYYQ.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 73
11 -22.800[OR] KOG0001 Ubiquitin and ubiquitin-like proteins  ali follow..  35  1....................................MQIFVKTLTGKITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLR.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 72
12 -22.400[S] KOG0013 Uncharacterized conserved protein  ali follow..  12  138.MISSNDPTKSPEEHDTTTKSIASLKDAELDSSLETVLIRYSKDDKDYSIQINPNLPFSHAKSQLEE--VGLENVQRFFFLGRVLQFKKSLSQQGWTSGMIIQAM.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 239
13 -22.400[O] KOG0006 E3 ubiquitin-protein ligase (Parkin protein)  ali follow..  25  1....................................MIVFVRNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLT................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 103
14 -22.400[A] KOG0007 Splicing factor 3a, subunit 1  ali follow..  17  664.PVDIMEEEPPSKKIRSEDNLIPEADFIATHKSPVTIQVLVKLNGQMIAVTMALSEPIANLKTKLQDETGMPPAKQKIFYEGMFFKDSNTMAFYNLVNGTTVHLQVKER................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 779
15 -20.200[OT] KOG2561 Adaptor protein NUB1, contains UBA domain  ali follow..  11  79...............................NDTGLATFNVRCVDQMLEIKCSLGGLGSDLQAEVAKKLDIDSSHVKCISGGRIINGQKTLASQGLKTNQHLMVVVGGTNEGQELHERIQRIRADLELVADADRFMEMEDQDG-----------------------------RPIFLPREENRSLLMAMSMYEVARVAMHKENFDEALLILLEADELFSQCDSKLLEGVDNYALIN--LDIV---------------RLKNITQLPDAQRRLDICERGFVKSYGEQFIRLFSIKGPSSPERALIMRLHLLQGVLLFHQNRRDEAYEKLEVAT----------------------------------------------KDLYEVKMNDTELSTLVEMGYEESDALALRSCAGQVDRAIQYIQERSERISEERKNSAAERQVNQEMIFAGQGGEWVNPRSIIRLMEM----------------------------------------ERRLVVEALKRTKNNLDRSLDLLQRHSDELRANLPPIPPVDESLLTTLQHLGF-SEISARDALETTGNSFHKSLKFLLKSFPN 517
16 -19.900[K] KOG4495 RNA polymerase II transcription elongation factor Elongin/SIII, subunit elongin B  ali follow..  19  1....................................MDVFLVIRRHKTTIDAKESSTVFELKRVVEGILKRPPDEQRLYKDYQLLDDGKTLGECGFTSQATVGLAFRAHDAFEALCIEPFSSPPELLDVMKPQESGSSA.................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 112
17 -19.600[S] KOG2632 Rhomboid family proteins  ali follow..  20  291..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ASNQSSEDSRFPGRGRTLSTARDPTAPAGETDPNLHARLLEDSSSPDRLSDATVNTVADSRQAPIANAAVLPQSQGRVAASEEQIQKLVAMGF-DRTQVEVALAAADDDLTVAVEILMSQQ.. 410
18 -18.600[O] COG5227 Ubiquitin-like protein (sentrin)  ali follow..  13  1MSESPSAN-ISDADKSAITPTTGDTSQQDVKPSTEHINLKVVGQDNNEFFKIKKTTEFSKLMKIYCARQGKSMNSLRFLVDGERIRPDQTPAELDMEDGDQIEAVLEQ................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 108
19 -16.900[D] KOG4842 Protein involved in sister chromatid separation and/or segregation  ali follow..  8  3..........................SHRMEDSGKKIRVSLLWKGNKYSVEIDSGASLKDLGYELRKLTGVTSETLRLIVPRLNEKSSLSLQESNIIEDKTIRMMGVSEEEVEGVLKEAVSDMRILGFEEEERRLKQKKSYVSSASIK----------------LPQGTYIFGDFRTLQLPGIELNPPPSAALKRMHMLAADPGIIAVMNKH-RVGIMTELAPVGYVGVSPRCLL---FNKNQGEEISLRLRTDDLKGFRKYQSIKK--HELAHMVYTEHDEKFYALDSQLNKEAESLDWTKSRGHTLNGTKFINDDDEEDYFFDENETVSQRLGGNQSDNLGNARESSVAAAYRRLSHTSVSKLSEEPDPDDLVDVRDENKQLVLPKAQSDSMTKFEPDPDDTTADDATKTESCHSYEMASDLAHPTKDDDEPDPDDSETHTSIGEVENMKIVNDTVMLCGNLNADEATQATPEPNNAEPYPDYNLVVTERETIMEVDEPDPDDQEIQRIQDSVTIISNRLKKAIKALRNEVSPGQATTQPNEMKFKR-VEILSVVGFVDEMVSESTLVLKRNDLWIAKSMIEESHPT 601
20 -16.800[YU] KOG2834 Nuclear pore complex, rNpl4 component (sc Npl4)  ali follow..  9  2.................................AESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNTASSNKSLNLLKIKHGDLLFLFPSSLAGPSSEMETSVPPGFKVFGAPNVVEDE..................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 109
21 -16.600[O] KOG1769 Ubiquitin-like proteins  ali follow..  17  1MSEEKPKEGV--------------------KTENDHINLKVAGQDGSVQFKIKRHTSLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLRMEDEDTIDVFQQQ................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 89
22 -16.100[S] KOG4463 Uncharacterized conserved protein  ali follow..  15  239...................................................................................................................................................................................................................................................................................................................................................................................................................................................................TGLDAERTENENQVENPVSNADANDSPTRQNARATAIASSSNTAASFRNRQQISHPPLGRTSSSSVLPTGPASQLYDMLSGRSERPELGNIREE----DINTVTIMQT-SRAQAIQALSQT-NDVQRAVELLLEQTAD 371
23 -16.000[S] COG5417 Uncharacterized small protein  ali follow..  20  2...............................AKNTHMNVTVNWGADKYDLRIPVHQPIKALIINLAETLKIEYKDIKTTNKAILLSDDDKLTNFQIADGDILEIL.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 83
24 -15.400[Y] COG5100 Nuclear pore protein  ali follow..  9  1....................................MLIRFRSKNGTHRVSCQENDLFGTVIEKLVGNLDPNADVDTFTVCEK--LADRTVMDLGLKHGDMLILNYSDKPANEKDGVNVEIGSVGIDSKGIRQHRYGPLRIKELA............................................................................................................................................................................................................................................................................................................................................................................................................................................................ 117
25 -15.300[S] KOG4351 Uncharacterized conserved protein  ali follow..  10  98MKNTGNVKWSADTK---------WGNLTLASTEKKDVLVPCLKAGHVGVVSV-------EFI--------APALE------GTYTS---RLSHKGQQFGPRVWCSIIVDPFPSEESPDNIEKGMISSSKTDDLTCQQEETFLLAKEERQLGEVTEQTEGTAACIPQKAKNVASERELYIPSVDLLTAQDLLSFELLDINIVQELERVPHNTPVDVTPCMSPLPHDSPLIEKPGLGQIEEENEGAGFKALPDSMVSVKRKAENIASVEEAEEDLSGTQFVCETVIRSLTLDAAPDHNPPCRQKSLQMTFALPEGPLGNEKEEIIHIAEEEAVMEEEEDEEDEEEEDELKDEVQSQSSASSEDYIIILPECFDTSRPLGDSMYSSALSQPGLERGAEGKPGVEAGQEPAEAGERLPGGENQPQEHSISDILTTSQTLETVPLIPEVVELPPSLPRSSPCVHHHGSPGVDLPVTIPEVSSVPDQIRGEPRGSSGLVNSRQKSYDHSRHHHGSSIAGGLVKGALSVAASAYKALFAGPPVTAQPIISEDQTAALMAHLFEMGFCDRQLNLRLLKKHNYNILQVVTELLQLNNN 659
26 -13.200[T] KOG1363 Predicted regulator of the ubiquitin pathway (contains UAS and UBX domains)  ali follow..  9  45IPQENGILQSEYGGETIPGPAFNPASHPASAPTSSMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKMLLKWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAGALQESLNQN............................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 193
27 -13.100[P] KOG1603 Copper chaperone  ali follow..  8  1MATDEMKSETKKTEHKQKQSTQIKQDLPPPTIPPLPLPCTLK-------VSIHCEGCKRKVKKILTSKVDIDVKQHKVTVIGII--SPEILLKKLNKAGKNAEQLPEIPDPVDNKPKPVDPKEKNKKKKKEEKVQITN................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 137
28 -12.700[S] KOG2827 Uncharacterized conserved protein  ali follow..  9  58IRPSSVVSMSGRSIAPSDSSENDDRHFDVDEEMESMSLDSPLPIEVPRPFPDKPYYWMNDYKTLEFIRTNFPSDSFYVMHNGKIIENFNAFIDENMQSLVKYSFHLRVRGGKGGFGSLLRSFRVNKSTNKLM-------------------------------------------------NGRRMASVDEEAKLKRYLEKQARKEQELKEKRKAKLEKLTAGPAKHMFEDQDYLSRREEIINKTE----------------DACEAGFALMLEMKRNSRKSKEQENKNDEDEDDDVNAEDVTDLFNDRGGRKRKIAAPSIGEDGGNKRINDESDDSEDDSENEVDPEELEAIRQYFEA-------------------------------------------------------------------------------------------------------------------------------KKQDEKDNGEGTSEAVPEVLVDEQEIEPAKRPRLDSASNIDDLPKIDVKTPCEYGPISLDDFTSAEDLELLGLEHLKSALNDRLKCGGSLVERAARLWC.... 457
29 -11.500[O] KOG4588 Predicted ubiquitin-conjugating enzyme  ali follow..  26  34.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NNSRPARQVRRLEFNQAMDDFKTM-FPNMDYDICVLRANSGAVDATIDQLLQ.... 86
30 -10.500[TO] KOG3288 OTU-like cysteine protease  ali follow..  18  2.................................TGSFSVKLKSKKGQFIVDLNEHTTLGELKTKIVQATDIEATQLHV-YPPKPLDEQRALKAVGINSGETLIVEEKAAPAPAAPVPGGTTVEDDEALARRLQAEEEA................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 114
31 -10.400[R] KOG2507 Ubiquitin regulatory protein UBXD2, contains UAS and UBX domains  ali follow..  12  366.QRFNTPDISSTTNSVAATAASNVITTDASVSSVDETRLQIRLPGGI---SFPAGEVLATVRVYVRNE-ASDVRDFTLAYPRREFQTEDTLNELNLVPNAVVLVLTKEQVNRVVQSGGS...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 491
32 -10.100[C] KOG4773 NADPH oxidase  ali follow..  18  425.ALPREPLSFSLPEKAPEKATNISIPESAPTTAGSTCKVKVRLGDETFALRVPSDISFEDFCERLTNKLG---ECEHLSYRDT-LNNVDDLRKA-CSQESGVLLFAERRR............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 535
33 -9.810[Y] KOG2086 Protein tyrosine phosphatase SHP1/Cofactor for p97 ATPase-mediated vesicle membrane fusion  ali follow..  11  261LGSTAPQVLSTSSPAQQAENEAKASSSILIDESEPTTNIQIRLADGGRVQKFNHSHRISDIRLFIVDA-AMAATSFILMFPNKELADESTLKEANLLNAVIV....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 367
34 -9.480[O] KOG2689 Predicted ubiquitin regulatory protein  ali follow..  10  219.EQKELGNAEPAPSVSSTTVSSPPAGVKSPPRDYTETRIQVRLQDGS---TFNVKEQLSAVRVFIQMK---IESPFSLMFPRKLFAEDDPLEVLGLVPSAVITMT.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 327
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.