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Query: [H] KOG0089 Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATNLast
1 -113.000[H] KOG0089 Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase  ali  100  1MSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN 344
2 -102.000[H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase  ali follow..  49  2.............................AAKIISGTELSKQIKANLADKITHYIEQGKRAPGLAVILVGADPASQIYVGNKRKSCEEVGILSKSYDLPETTTQNELLAIIDQLNADKNIDGILVQLPLPKQINAEAIIERIDPKKDVDGFHPYNVGRLCQRIPTLRACTPYGVMKLLETTGIDLHGKHAVIVGASNIVGRPMSLELLLAG--------ATVTVTHRFT--KNLENHVRQADILVVAVGKPNLISGDWIKESAVVIDVGINRV------DGKLVGDVEFDKAAEKAAYITPVPGGVGPMTVAMLMSNTLYAYEHNK.................. 282
3 -78.400[H] KOG4230 C1-tetrahydrofolate synthase  ali follow..  40  1.............................MALLLEGTSLARKVREELREQISSIKSVDYFNVSLKIIQVGGREDSNVYVRMKTRAANEAGISCEHVNFPEDITEYDLLLAIKGFNEDPTVHGIIVQLPLPAHINEQIITEAVAPEKDVDGFCETNLGKLTKRQPLFTACTPKGIMCILKHYGINVQGKHAVVIGRSNIVGRPMSILLEKAN--------ATVTLCHSKT--ESIADIVRTADIVVAAIGIPHFVKADWLKKGVVAIDVGINSIPDATKKSGRLTGDIDFENAKEVASAITPVPGSVGPMTVAMLLQNVVESAVRFRKMSRKRKPTLLPLKLQT. 308
4 -12.200[R] COG5322 Predicted dehydrogenase  ali follow..  19  67...................................................................................................................QGAVCEGILHYMPLAEEM-AQRVVDAVESLKDQ-GAQVVGLGPVTTGNSLTAYAAYRNVLESMDRLGVEPADTEVAVVGYPGSIALVIAKLLAGHGCRLCLVHRGSEAQGRQGLASNDIEHCYEHVQFYVAATSTGGLIDPYRLRPGSVVVDAALPR---------------DVKPYRKDRNDILIIDGGL...................................... 279
5 -10.200[E] COG0169 Shikimate 5-dehydrogenase  ali follow..  11  10...................................................................VFGNPINHSKSPFIHTLFARQTQQSMIYTAQ--CVPVDGFTEAAKHFFA-QGGRGCNVTVPFKEEAYRDRLTERARLAGAVNTLKKLDDGEILGDNTD------EGLVQDLLAQQVLLKGATILLIGAGG-AARGVLKPLLDQQPASITVTNRTFAKAEQEVKAQAFEQLKQSYDVIINSTGELPAIDPVIFSSRSVCYDMMYGKGYTVFNQWARQHG-------------CAQAIDGLG-----MLVGQAAESFMLWRGLRPGTKQILREL..... 270
6 -6.180[E] COG0686 Alanine dehydrogenase  ali follow..  16  1..........................................MIIGVPKEIKNHEYRVGMIPASVRELVSHGHQ----VYVETNAGSGIGFSDDDYI----AVGASILPTAADVFAKAEM--VKVKEPQAIERADFPQTEELIKSKAYETVTDNMAGRMSIQAGAQTLEKSRGGSGLLLGGVPGVAPAKVVVLGGGVVLRADVTILDRNIDTLRKLDEEFQGRANVVYSTADAIEKYVLEADLVIGAV-APKLVTQQHIKPGSAVVDVAIDQGGCFETSHPTTHAEPTYIVDDVVHYCVANMPGAV-ARTSTFALNNAT......................... 317
7 -5.980[E] KOG2250 Glutamate/leucine/phenylalanine/valine dehydrogenases  ali follow..  17  133...................EGYRAQHSQHRTPCKGGIRYSTDVSVD---EVKALASLMTYKCAVVDVPFGGAKA---------------GVKIN----PKNYTENELEKITRRFTMELAKKGFIVDVPAPDNTGEREMSWIADTYASTIGHYDINAHACVTGKPISQSATGRGVFHGIENFTPGFRDKTFVVQGFGN-VGLHSMRYLHRFGAKCIAVGESDGSIWNPDAKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGAN---------GPTTPEADKIFLERNILVIPDLYLNAGGVTVSYFLKNLNHVSYGRLTFKYE............. 459
8 -5.820[E] KOG3007 Mu-crystallin  ali follow..  10  105...............................................................................................................................................................QLDGNELTSRRTAAASALASSYLSKEDSTSLLIIGSGKVAEKLIHAHCSVRPIRSVRIWNHRFESAKSLASRQNLENAVKCSDIISSATSKKPIIVGSWINPGTHIDLVGMHEADSKCIQISNVFVDTRKGALHEAGDLLTPIKEGL--FSPNEVIADLFDLCNNKHSGRSQLKNPAEAITL... 305
9 -5.660[H] COG0499 S-adenosylhomocysteine hydrolase  ali follow..  19  200....................................................................................................................EETTTGV--VLPFP--------------------AMNVNDAVTKSKFDNKYGTRHSLIDGINRATDMLMGGKNVLVCGYGD-VGKGCAEAFDGQGARVKVTEADPINALQALMSVVTVDEAIEDADIVITATGNKDIISFEKMKDHALLGNIG........................................................................... 345
10 -5.660[H] COG0373 Glutamyl-tRNA reductase  ali follow..  13  8.................................INHNTASVELREKVAEKLSLALNQLSTSSHVKGVILSTCNRTEIYCDVRSASKNKV---IEWLSQFHQVSLDELKPSLYVHEEQAAIRHLMVACGLDS-LGEPQILGQVKQAYAE---KAFSVAKRVRTETEI--SVAYAACTLAKHIFESLADATVLLVGAGE-TIELVAKHLAGHHCKRMIVANRTRERALSLAQQNEIPDYLAQADIVISSTASPLIIGKGMVES-MLLVDIAVPRDIEPQVGKLNDAYLYSVDDLQSIVD............................................... 306
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.