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Query: [R] KOG0091 GTPase Rab39, small G protein superfamily, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVEPIFEYQFRLILIGDSTVGKSSLLKFFTDGKFAELSDPTVGVDFFARLIEMKDGTQIKLQLWDTAGQERFRSITKSYYRNSVGVLLVYDISNHASFEHIPLWMMEAQRHIEPHRPVFALVGCKLDLINAGGHREVTTEEAQKFAKQHGLHFVETSARSGANVEEAFRMVTQEVYARIRSGEYKAEDGWDGIKSGFSRPNSLDFNLVVAEPEKSSCCLast
1 -98.500[R] KOG0091 GTPase Rab39, small G protein superfamily  ali  100  1MVEPIFEYQFRLILIGDSTVGKSSLLKFFTDGKFAELSDPTVGVDFFARLIEMKDGTQIKLQLWDTAGQERFRSITKSYYRNSVGVLLVYDISNHASFEHIPLWMMEAQRHIEPHRPVFALVGCKLDLINAGGHREVTTEEAQKFAKQHGLHFVETSARSGANVEEAFRMVTQEVYARIRSGEYKAEDGWDGIKSGFSRPNSLDFNLVVAEPEKSSCC 218
2 -88.800[U] KOG0081 GTPase Rab27, small G protein superfamily  ali follow..  33  1MSDGDYDYLIKFLALGDSGVGKTSVLYQYTDGKFNSKFITTVGIDFREKRVVYRAGQRIHLQLWDTAGQERFRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYCENPDIVLCGNKSDLED---QRVVKEEEAIALAEKYGIPYFETSAANGTNISQAIEMLLDLIMKRMERCVDKSWIPEGVVRSNGHASTD-----QLSEEKEKGAC 219
3 -88.600[U] KOG0087 GTPase Rab11/YPT3, small G protein superfamily  ali follow..  42  3.QEDEYDYLFKTVLIGDSGVGKSNLLMRFTRNEFNIESKSTIGVEFATRNIVL-DNKKIKAQIWDTAGQERYRAITSAYYRGAVGALIVYDITKQSSFDNVGRWLKELREHADSN-IVIMLVGNKTDLLH---LRAVSTEEAQAFAAENNLSFIETSAMDASNVEEAFQTVLTEIFRIVSNRSLEAGDDGVHPTAGQTLNIAPTMNDLNKKKSSSQCC 214
4 -88.400[U] KOG0097 GTPase Rab14, small G protein superfamily  ali follow..  40  4.APYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEV-SGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPN-TVIILIGNKADLEA---QRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCGC 215
5 -88.400[U] KOG0086 GTPase Rab4, small G protein superfamily  ali follow..  39  1.MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVEFGSRVVNV-GGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLASPN-IVVILCGNKKDLDP---EREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDPERMGSGIQYGDASLRQLRQPRSAQAVAPQPCC 213
6 -88.200[TU] KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins  ali follow..  38  1MSTKSYDYLIKLLLIGDSGVGKSCLLLRFSEDSFTPSFITTIGIDFKIRTIEL-DGKRIKLQIWDTAGQERFRTITTAYYRGAMGILLLYDVTDKKSFDNVRTWFSNVEQHASEN-VYKILIGNKCDCED---QRQVSFEQGQALADELGVKFLEASAKTNVNVDEAFFTLAREIKKQKIDAENEFSNQANNVDLG-------------NDRTVKRCC 200
7 -87.900[U] KOG0095 GTPase Rab30, small G protein superfamily  ali follow..  35  1MSMEDYDFLFKIVLIGNAGVGKTCLVRRFTQGLFPPGQGATIGVGFMIKTVEI-NGEKVKLQIWDTAGQERFRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYASNK-VITVLVGNKIDLAE---RREVSQQRAEEFSEAQDMYYLETSAKESDNVEKLFLDLACRLISEARQNTLVNNVSSPLPG-------------EGKSISYLTCC 200
8 -87.300[U] KOG0098 GTPase Rab2, small G protein superfamily  ali follow..  46  2....SYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMVTI-DGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTSWLEDARQHSNSN-MVIMLIGNKSDLEA---RREVKREEGEAFAREHGLVFMETSAKTAANVEEAFIDTAKEIYRKIQEGVFDINNEANGIKLGPQHSPSSPNNATGGLGGGSGCC 214
9 -86.800[R] KOG0080 GTPase Rab18, small G protein superfamily  ali follow..  35  1.MDEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISV-DGNKAKLAIWDTAGQERFRTLTPSYYRGAQGVILVYDVTRRDTFVKLDNWLNELETYCTRNDIVNMLVGNKIDKEN----REVDRNEGLKFARKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWESENQNKGVKLS---------HREEGQGGGACGGYC 203
10 -86.400[TU] KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins  ali follow..  42  1.MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDSYLDSYISTIGVDFKIRTVEQ-DGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVTYDVTDLESFNNVKQWLNEIDRYASEN-VNKLLVGNKCDLTS---QKVVSTETAKAFADELGIPFLETSAKNATNVEEAFMAMTAAIKTRMASQPAGGSKPPT------------VQIRGQPVNQQSGCC 200
11 -86.000[R] KOG0079 GTP-binding protein H-ray, small G protein superfamily  ali follow..  37  3.GTRDYDHLFKLLIIGDSGVGKSSLLLRFADNTFSENYITTIGVDFKIRTMDI-NGQRVKLQIWDTAGQERFRTITSTYYRGTHGVVVVYDVTNGESFGNVKRWLQEIENNC--DSVQKVLVGNKCEENE---RRVVLESDARNYAQSMNISFFETSAKEDKNVEPMFTCITSLVLTAKLANPQSASKDQSRTG-----GVSLKDNSGSTNQKKKCKC 208
12 -85.500[U] KOG0093 GTPase Rab3, small G protein superfamily  ali follow..  33  15.SDQNFDYMFKILIIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTIYR-NDKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDN-AQVLLVGNKCDMED---ERVVSSERGRQLADHLGFEFFEASAKDNINVKQTFERLVDVICEKMSESLDTADPAVTGAKQG------PQLSDQQVPPHQDCAC 220
13 -85.100[R] KOG0088 GTPase Rab21, small G protein superfamily  ali follow..  30  4TNVDQKSFKFKIVLLGEGCVGKSSLVLRFVENKFSCKHLSTIQASFQNKTVNV-EDCQADLHIWDTAGQEKYHALGPIYYRGSNGVLLVFDITDRKSFEKVKNWVLEIKTCLGNT-AEILIVGNKIDLEE---ERQVTRQDAEAYAESEGALYMETSAQDNVGISDAFESLTAKMIEHSRTRSTEPPSTNRSIRLI----------DNDEAERSKKCC 206
14 -84.800[U] KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases  ali follow..  36  13.NTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCL-DDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPN-IVIALSGNKADLAN---KRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVDLT-----------EPTQPTRNQCC 213
15 -84.400[U] KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily  ali follow..  32  1MASVSPLAKYKLVFLGDQSVGKTSIITRFMYDKFDTTYQATIGIDFLSKTMYL-EDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDVANRLSFLNTSKWIEEVRNERAGD-VIIVLVGNKTDLVE---KRQVSIEEGDSKGREYGVMFIETSAKAGFNIKPLFRKIAAALPGMESYSNTKNEDMVDV--------NLKPTSNSSQGDQQGGAC 205
16 -81.000[T] KOG4252 GTP-binding protein  ali follow..  28  1MLEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQV-NDEDVRLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRGSFEAVSSWREKVVAEV--GDIPTVLVQNKIDLLD---DSCIKNEEAEALAKRLRLRFYRTSVKEDLNVNEVFKYLAEKYLQKLKQQIAEDPELTHSSSNK---IGVFNTSGGSHSGQNSGTL 209
17 -80.700[R] KOG0394 Ras-related GTPase  ali follow..  31  1.MPSRRRTLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVQF-EDRLFTLQIWDTAGQERFQSLGVAFYRGADCCVLVYDVNSMKSFENLNNWREEFLIQASPENFPFVLIGNKVDVDD-GNSRVVSEKKAKAWCASKGIPYFETSAKVGTNVEEAFQCIAKDALKSGEEEELYLPDT-------------IDVGTSNQQRSTGCEC 206
18 -73.700[U] KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily  ali follow..  21  5.AANGEVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATIGVEVHPLSFYT-NFGEIKFDVWDTAGQEKFGGLRDGYYINAQCAIIMFDVTSRITYKNVPNWHRDLVRVC--ENIPIVLCGNKVDVKERKV-----KAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLAGNPQLEFVASPA------LAPPEVQVDEQLMQQYQQEMEQAT 207
19 -70.600[R] KOG1673 Ras GTPases  ali follow..  16  93SSSDSDLVSLKISLLGDCQTGKTTFVVKYVGDEN-QSFLEMTGLNLMDKTFYV-QGVTISFSIWDVGGDERSKDHIPIACKDAVAILFMFDLTSRSTLNSVFGWYSQARKWN--KTAIPILIGTKFDDFVRPNLQWTIVTQARAYAKVMNASLFFSSATHNINVNKIFKFILARLFNLPWKIDRNLTLGEPIIDYDS..................... 288
20 -67.300[R] KOG0083 GTPase Rab26/Rab37, small G protein superfamily  ali follow..  36  462..EDEFDIMGKVIMLGDSGVGKTSLLIRFRDGRYVPSYLSTVGIDFRNKVVVV-DGTRVKLQIWDTAGQERFRSVTHAYYRDAHALLLLYDVTNKTTYDNIRAWLGEIREYAQED-VVIVLIGNKADCSG--SERQVKREDGERLGREHNVPFMETSAKTGLNVELSFTAVARQLKSRGYEHGDDGKFN--------------VHDFVRDNTKARSVC 660
21 -63.800[R] KOG0395 Ras-related GTPase  ali follow..  19  12.LSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIE-DFHRKVYNI-RGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVKEAAELPMVICGNKNDHGE--LCRQVPTTEAELLSGDENCAYFEVSAKKNTNVDEMFYVLFSMAKLPHEMSPALHRKISVQYGDAFHPR-----PFCMRRVKEMDAY 228
22 -48.900[R] COG2229 Predicted GTPase  ali follow..  16  4.........NKIIFTGPVGVGKTTAIAAISDEALVQTDATTVAMDYGAISL----DEDTKVHLYGTPGQERFNFMWEILSQGSMGLVLLLDNARTNPLKDLEFFLHSFRGLL--EKAPVVVGITKMDIRS---QPGIDVYHKYLAKHNLNVPVFEIDARKEDDVKQLVSAMLFSIDPGLE...................................... 177
23 -45.200[R] KOG0393 Ras-related small GTPase, Rho type  ali follow..  25  4.........IKCVVVGDGAVGKTCLLLSYTTNAFPGEYILTVFDTYSTNVM---DGRPINLSLWDTAGQDDYDQFRHLSFPQTDVFLVCFALNNPASFENVAKWYPEVSHHCP--NTPIILVGTKADLREDRDLQPVSHTQGYVMAKEIKVKYLECSALTQIGLKQVFDEAIRTGLTPPQTPQTRAKKS............................. 190
24 -35.000[R] KOG0075 GTP-binding ADP-ribosylation factor-like protein  ali follow..  22  21.........MELTLVGLQFSGKTTFVNVIASGQFAEDMIPTVG--FNMRKITRGN---VTIKVWDIGGQPRFRSMWERYCRGVNAIVYMVDAADLDKLEASRNELHSLLDKPQLAGIPVLVLGNKRDLPGALDETGLIERMNLSSIQDREICCYSISCKEKDNIDITLQWLIQHSKSQSR...................................... 186
25 -34.100[T] KOG3886 GTP-binding protein  ali follow..  16  33.VLPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTGATILDRIHSLQIHVRFLGNLVLNLWDCGGQDTFMSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSDAKIFCLVHKMDLVQEDQRDLIEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQLIPNVQQ..................................... 247
26 -33.100[R] KOG0074 GTP-binding ADP-ribosylation factor-like protein ARL3  ali follow..  23  18.........VRILLLGLDNAGKTTLLKQLASEDIS-HITPTQG--FNIKSVQSQG---FKLNVWDIGGQRKIRPYWKNYFENTDILIYVIDSADRKRFEETGQELAELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQSCSALTGEGVQDGMNWVCKNVNAKKK...................................... 182
27 -32.900[U] KOG0071 GTP-binding ADP-ribosylation factor Arf6 (dArf3)  ali follow..  20  22.........MRILMLGLDAAGKTTILYKLKLNQSV-VTIPTVG--FNVETVTYKN---IKFNVWDVGGQDKIRPLWRHYFTGTKGLIFVVDSADSNRISEARQELHRIISDREMRDCLLLVLANKQDLPGALSPAQITDVLQLDKLKDRLWNVQPTCALTGDGLLEGLAWLSQNAKLK........................................ 184
28 -32.700[U] KOG0072 GTP-binding ADP-ribosylation factor-like protein ARL1  ali follow..  22  18.........MRILILGLDGAGKTTILYRLQVGEVV-TTIPTIG--FNVEQVTYKN---LKFQVWDLGGQTSIRPYWRCYYSNTDAIIYVVDSADRDRIGISKDELLYMLREEELAGAILVVLANKQDMDGCMTVAEVHHALGLENLKNRTFQIFKTSATKGEGLDQAMDWLSNTLQSR........................................ 180
29 -32.700[U] KOG0070 GTP-binding ADP-ribosylation factor Arf1  ali follow..  23  18.........MRILMVGLDAAGKTTILYKLKLGEIV-TTIPTIG--FNVETVEYKN---ISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRDRVVEARDELHRMLNEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRQRHWYIQSTCATSGEGLYEGLDWLSNNIASK........................................ 180
30 -32.400[UZ] KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2  ali follow..  21  17.........LRLLMLGLDNAGKTTILKKFNGEDID-TISPTLG--FNIKTLEHRG---FKLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSADRQRMQDCQRELQSLLVEERLAGATLLIFANKQDLPGALSSNAIREALELDSIRSHHWCIQGCSAVTGENLLPGIDWLLDDISSRIFT..................................... 182
31 -32.300[R] COG1100 GTPase SAR1 and related small G proteins  ali follow..  22  19.........LRILILGLDGAGKTTILYRLQIGEVV-TTKPTIG--FNVETLSYKN---LKLNVWDLGGQTSIRPYWRCYYADTAAVIFVVDSTDKDRMSTASKELHLMLQEEELQDAALLVFANKQDQPGALSASEVSKELNLVELKDRSWSIVASSAIKGEGITEGLDWLIDVIKEE........................................ 181
32 -31.700[S] KOG4273 Uncharacterized conserved protein  ali follow..  14  2......ESRPGVLVVGSSGVGKRTLLSRLLSVEFEDSSESSSQTEVHGWTINTK--YTADVSVCISHICDEYSLPNLPNSHPLVALVMVFDLSELSTLVALQDWVSHTDINSFD---ILLCIGNKVDREYRRRLLKASDPSRDLYSDIDDFGISETEGSSLLGSEDASLDIRGACLE......................................... 176
33 -30.700[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali follow..  18  18.........YSILILGLDNAGKTTFLETLKKEYSLAKIQPTVG--QNVATIPVDSKQI--LKFWDVGGQESLRSMWSEYYSLCHGIIFIVDSSDRERLDECSTTLQSVVMDEEIEGVPILMLANKQDRQDRMEVQDIKENKIAEHISARDSRVLPISALTGEGVKDAIEWMIVRLERNKKS..................................... 192
34 -29.800[U] KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1  ali follow..  18  21.........AKILFLGLDNAGKTTLLHMLKDERLV-QHQPTQH--PTSEELSIGK---IKFKAFDLGGHQIARRVWKDYYAKVDAVVYLVDAYDKERFAESKRELDALLSDEALATVPFLILGNKIDIPYAASEDELRYHLGLGDSGVRPLEVFMCSIVRKMGYGEGFKWLSQYI........................................... 192
35 -27.700[V] KOG1707 Predicted Ras related/Rac-GTP binding protein  ali follow..  13  15.........IRIVVVGEKGSGKSSLIMAAARNTFHPNIPSLLPYTNLPSEF---FPDRIPATVIDTSSRPEDKGKVVKEVRQADAIVLTFAFDRPETLDRLSKWLPLFRQLEV--RVPIIVAGYEVDNKEAYNHFSIEQITSALMKQYREVTSIQWSAQRLDQAKDVLYYAQKAVI.......................................... 178
36 -24.700[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  16  57..........TVLLSGLSGSGKTVLFYQLRDGSSHQGAVTSMEPNEGTFVLNTKKGKVKPVHLIDVPGHSRLISKLEEYLPRAAAVVFVVDALELPNIRAASEYLYDINASVIKNKTPVLLCCNKTDKVTAHTKEFIRKQMEKEIDKLRVSRSAISTADIANDF...................................................... 217
37 -19.600[U] KOG3887 Predicted small GTPase involved in nuclear protein import  ali follow..  19  64..........RILLMGLRRSGKSSIQKVVFHKMSPNETESTNKICRE----DVSNSSFVNFQIWDFPGQIDFFDPTEMIFRGTGALIFVIDSQDDYMEALARLHLTVTRAYKVNTDINFEVFIHKVDGLSDDHKIETQRDIHQRANDDLHLSFYLTSIYD-HSIFEAFSKVVQKLIPQLPT..................................... 243
38 -16.700[R] COG0218 Predicted GTPase  ali follow..  18  27..........EIALAGRSNVGKSSFINTMLNRKNLARTSGKPGKTQLLNFFNIDD----KMRFVDVPGREKWGCMIEEYLTTRRAVVSLVDLRHDPSADDV-----QMYEFLKYYEIPVIIVATKADKIPRGKWNKHESAIKKKLNFDPSDDFILFSSVSKAGMDEAWDAILEKL........................................... 195
39 -16.300[R] KOG2486 Predicted GTPase  ali follow..  21  137..........EFALVGRSNVGKSSLLNSLVRRKRLALTSKKPGKTQCINHFRIND----KWYLVDLPGKQDWNKFTKDYFLNLVSVFLLVDASIPVKPID-----LEYASWLGQNQVPMTLIFTKCDKRKKKKNGGKKPEANIKEFQDL--PWIMTSSVTNQGRDEILLHMAQLRNYWLKH..................................... 318
40 -16.100[E] COG4917 Ethanolamine utilization protein  ali follow..  12  1........MKRIAFVGSVGAGKTTLFNALQGNYTLARKTQAVEFN--------------DKGDIDTPGHPRWYHALITTLQDVDMLIYVHGANDPES-------RLPAGLLDIGVSKRQIAVISKTDMPDADVAATRKLLLETGFEEP----MFELNSHDPQSVQQLVDYLASLTKQEEAGEKTHHSE.............................. 159
41 -15.500[R] COG1084 Predicted GTPase  ali follow..  15  164..........TVVIAGFPNVGKSTLLRTLTGAEPEVADYPFTTKGIQIGHLERKW----RIQVIDTPGNNIELQAMVALENIADVIMFIFDASETCGYTLESQ-YSLYLGIRSVFDIPVVTVFNKMDLAENVKYLEEYINMVEDP--------LKVSAFEGRGVSKIIKKLEGLYEKETREAHDNV................................ 336
42 -14.200[R] KOG1489 Predicted GTP-binding protein (ODN superfamily)  ali follow..  18  335....ELKSIADLGLIGLPNAGKSTILNKISNAKPKIGHWQFTTLSPTIGTVSLGFGQD-VFTVADIPGASLDKGMGLEFLRHSNGWVFVLDLSNKNPLNDLQLLIEEVGTLEKVKTKNILIVCNKVDIDAEKSESFAKYLQVEKFSKSQEWDCVPISALREKT....................................................... 499
43 -14.200[R] COG3596 Predicted GTPase  ali follow..  11  40..........VIGIMGKTGAGKSSLCNALFAGEVSDVAACT---DPLRFRLQIGE---HFMTIVDLPGDTEYAALYREQLPRLDLILWLIKADDRALATD-EHFYRQVIGEAYRHKMLFVI--SQSDKAEPTSGGNILSTEQKQNISRK--PVCAVSVRLQWGLRVMAERMIKCL........................................... 216
44 -13.400[R] KOG0410 Predicted GTP binding protein  ali follow..  20  311..........VVSLVGYTNAGKSTLLNQLTGANVLAENRLFATLDPTTRRVQMQNGKEFLLT--DTVG-AAFRA-TLEEIAESSLLVHVVDISHPLAEQQIEA-VEKVMSELDVSSIPKLVVWNKVDR--------VDDPQKVKLEAEETGDTICISALTGEGLDDFCNAVHEKLKDSMVW..................................... 478
45 -13.400[J] KOG0462 Elongation factor-type GTP-binding protein  ali follow..  16  34LSEFTPDKIRNFGIVAHVDHGKSTLADRLLEGAVPPGQKQMLGITVKAQTAALR--RGYLLNLIDTPGHVDFSAEVSRSLAVCDGILLLVAAN-----QGVQAQTIANFWLAFEKNIQIIPVINKIDLPGADIKSVE--TQLKNLFEFNPEECLHISAKSGLNVDKVLEAIIDRV........................................... 211
46 -13.300[M] COG0481 Membrane GTPase LepA  ali follow..  18  2......KNIRNFSIIAHIDHGKSTLSDRLIQTC-SMDLERERGITIKAQSVTLKDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAG-----QGVEAQTLANCYTAIEMNLEVVPILNKIDLPAADPERVA--EEIEDIVGIDAMEAVRCSAKTGVGIEDVLEEIVHKI........................................... 180
47 -12.700[J] KOG1145 Mitochondrial translation initiation factor 2 (IF-2; GTPase)  ali follow..  18  183...........VTIMGHVDHGKTTLLDKFRKTQVAAVETGGITQHIGAFLVSLPSGEKITF---DTPGHAAFSAMRA---RGAQVTDIVVLVVAAD--DGVMKQTVESIQHAKDAQVPIILAVNKCDKAEADPEKVKKELLAYDVVCEDDVQAVPVSALTGDNLMALAEATV.............................................. 339
48 -12.600[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  14  171...........VLICGYPNVGKSSFMNKVTRAD-----VDVQPYAFTTKSLFVGDYKYLRYQVIDTPG-EMCSITALAHLRAAVLFFLDISGSCGYTIAQQAALFHSIKSLFMNKPLVIVC--NKTDLMPMENISEEDRKLIEEMKSEEEQVLLKMSTLTDEGVMSVKNAACERLLDQRVEAKMKSKK.............................. 362
49 -12.000[J] COG3276 Selenocysteine-specific translation elongation factor  ali follow..  15  1............MIIVTSG-GKTALLKALTTAHLPEEKKRGMTIDLGYAYLPLENK---VLGFIDVPGHEKF---LSNMLAGLGGVAMLIVAADEGVAVQTKEHLAILRQLQFHEIIVVI---TKADRTNSAQIESLIQTIKQDYSFLRNANYFVTSAETGQGISELRHYLANLAELADTQK.................................... 169
50 -11.500[R] COG2262 GTPases  ali follow..  23  199..........TVSLVGYTNAGKSTLFNRITEARVYAADQLFATLDPTLRRIDVADVGETVLA--DTVG-AAFKA-TLQETRQATLLLHVIDAADVRVQENIEA-VNTVLEEIDAHEIPTLLVMNKIDMLEDFEPRIDRDEENKPIR-------VWLSAQTGAGIPQLFQALTERLSGEVAQ..................................... 367
51 -11.200[TU] KOG1954 Endocytosis/signaling protein EHD1  ali follow..  12  84LDDPDFDAKPMILLVGQYSTGKTTFIRYLLESDFPGRALSGFGNAFLNRFSTLPNQVLESVTIVDTPGIDRFTGVLEWFAERVDRIILLFDAHKLDISDEFKRCIEALAGN--EDKIRIVL--NKSDMVDHQQ--SLGKVFKTPEVSRVYLGSFWDHPLHYDLNRRLFQDEQHDLFQDLQA..................................... 318
52 -10.900[R] COG1160 Predicted GTPases  ali follow..  18  217..........KIAIVGRPNVGKSTLTNRILGED-RVVVFDMPGTTRDSIYIPMERDGQ-QYTLIDTAGVRKRGKVTLQAIQDANVVLLTIDARENISDQD-----LSLLGFILNAGRSLVIVVNKWDGLDQDVKDRVKSELDRRLDFIDFARVHFISALHGSGVGNLFDSIKEAYACATQK..................................... 391
53 -10.500[J] KOG1191 Mitochondrial GTPase  ali follow..  17  354.........LQIAIVGRPNVGKSSLLNAWSERAIVTEVAGTT--DVVEANVTVRG---VPITLLDTAGIRETNDISETAAKVADVIIMAVSAVEGWTEEDTE--FYDLFGGLLYLKQPMILVMNKIDCAPPGSCDQLEDQRKKEEVFH---KSVFTSAVTGQGIEELEDAILEIL........................................... 533
54 -10.200[T] COG1217 Predicted membrane GTPase involved in stress response  ali follow..  13  3......ENLRNIAIIAHVDHGKTTLVDKLLKLS-SNDQEKERGITILAKNTAIK--NGYNINIVDTPGHADFGGEVERVMSMVDSVLLVVDAQ-----DGPMPQTRFVTQKAFKAGLRPIVVVNKIDRPGARPDWVIDQIFDLFDNLGATDEQLDFPIVYASALN..................................................... 169
55 -10.200[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  10  4........PLIIGVGGPVGAGKTMLIERLTRYLSTKGYSMAASMNFAAIEEMCDKHPDLQLLFLESGGD----LSATFSPDLVDFSIYIIDVAQGEKIPRKGGQGMIKSD---------LFIINKVDLAPY-VGANVEVMKADTLKSRGNKDFFVTNLKTDEGLKSVADWIEKRLQLALLEE.................................... 206
56 -10.200[J] KOG0468 U5 snRNP-specific protein  ali follow..  17  129......PLIRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEEGCSIKATPVTLVKQKSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAA-----EGVMLNTERLLKHAVQERQAITVCINKIDRLILELKLPPQ................................................................................ 274
57 -10.100[R] COG1159 GTPase  ali follow..  16  1MSTDKTYCGF-IAIVGRPNVGKSTLLNKLLGQKISRKAQTT-----RHRIVGIHTEGPYQAIYVDTPGNRLMNKAASSSIGDVELVIFVVEGTRWTPDD------EMVLNKLRDGKAPVILAVNKVDNVQEKVDLLPHLQFLASQMNFLDI--VPISAETGMNVDTIAGIVRKHL........................................... 173
58 -10.100[P] COG0370 Fe2+ transport system protein B  ali follow..  17  4.........NTYCILGNPNTGKTSLFNALTGSYEYVGNWSGVTVEKKVGTLRSKTGKLIDLPIYDLNPISRDETVVTRFLLEEK-MLNIVDSSQIERNLNLTVQLLEY-------GAPVVMGLNMIDVAAGRGIHL----NIQNLAKKLRIPILPVVARSGKGTEDILSTLSEKHVAPAI...................................... 166
59 -9.950[P] COG2895 GTPases - Sulfate adenylate transferase subunit 1  ali follow..  19  19MIAQQHKSLLRFLTCGSVDDGKSTLIGRLLHDTRQIYEDQLSSLHNDSKRHGTQGEKLDLALLVDGLQAEREQGITYRYFSTEKRKFIIADTPGHEQY------TRNMATGASTCELAILLIDNKMDLVDYSEETTRIREDYLTFAGQLPIRFVPLSALEGDNVAS.................................................... 215
60 -9.800[J] KOG0469 Elongation factor 2  ali follow..  15  1MVNFTVDEIRALMVIAHVDHGKSTLTDSLVSKA-TRKDEQERCITIKSTAISLEKYNGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCV-----SGVCVQTETVLRQAIAERIKPVLFMNKMDRALLELQLGAEFQTFQRIVENINVIIATYGDDDGPMGPIMVDPSIGNVG.......................................... 224
61 -9.740[J] KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  12  42.........INIGTIGHVAHGKSTVVKAISTVRFKNELERNITIKLGYANAKIPECYRSHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQ---NKIDLVKERQAKEQYEQILAFVQGTEGAPIIPISAQLKYNIEVVCEYIVKKI........................................... 243
62 -9.700[J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  17  5..........SEINIGLVG-GKTTLTKALSTDTHSEETKRGISIRLGYADITFRKCPQ-KVSFVDAPGHETLMATMLSGAALMDGAILVIAANEPCPQPQTKEHLMALDVIGVKDVIVVQ---NKIDIVSKERALESYREIKEFVKGTEDAPIIPVSAQQGANIDILIETIEERI........................................... 197
63 -9.650[J] COG0532 Translation initiation factor 2 (IF-2; GTPase)  ali follow..  20  448...........VTIMGHVDHGKTTLLDRFRESRVTEGEAGGITQHIGAYQIKANGK---KITFLDTPGHEAFTSMRA---RGASVTDITILVVAAD--DGVMPQTIEAINHSKAAGVPIIVAINKIDKPGANPQRVTQE--PVAWDPENGSEFVEISAKFNQNLDELLDTVL.............................................. 605
64 -9.610[J] KOG0458 Elongation factor 1 alpha  ali follow..  15  168.........LSFVVLGHVDAGKSTLMGRWIMDQTNEERERGVTVSICTSHFSTHR----NFTIVDAPGHRDFVPNAIMGISQADMAILCVDCSTESGFDLDGQTKEHMLLASSLGIHNLIIAMNKMDNVDWSQQR---KSKLLPYLVDIGINWVPISGFSGEGVYK.................................................... 361
65 -9.460[O] KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis  ali follow..  12  76.........MKVAFFGRTSSGKSSVINAMLWDKVLPSGIHITNCHALHMDKDLKAGCLVRLVLVDSPGTTELDSWIDKFCLDADVFVLVANSESTLMNTE-KHFFHKVNEWLSKPNI--FILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVANALEAQNRIFFVSAKEVLSARKQKA................................... 296
66 -9.300[H] COG3172 Predicted ATPase/kinase involved in NAD metabolism  ali follow..  11  6......FFVRTVAILGGESSGKSTLVNKLAN-IFNTTSAWEYGRDYVFSHLGGDEIA---LQYSDYDKIALGHAQYIDFAVKYANKVAFIDAFCKKYEGREHPFVQALIDEYRFDLVILLWVADGLRSLGSSVDRKEFQNLLVEMLEENNIEFVRVE---EEDYDSRFLRCVELVREMMGEQR................................... 187
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Liu T, Rojas A, Ye Y, Godzik A. Homology modeling provides insights into the binding mode of the PAAD/DAPIN/pyrin domain, a fourth member of the CARD/DD/DED domain family. Protein Sci. 2003 Sep;12(9):1872-81.