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Query: [O] KOG0185 20S proteasome, regulatory subunit beta type PSMB4/PRE4, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNHDPFSWGRPADSTYGAYNTQIANAGASPMVNTQQPIVTGTSVISMKYDNGVIIAADNLGSYGSLLRFNGVERLIPVGDNTVVGISGDISDMQHIERLLKDLVTENAYDNPLADAEEALEPSYIFEYLATVMYQRRSKMNPLWNAIIVAGVQSNGDQFLRYVNLLGVTYSSPTLATGFGAHMANPLLRKVVDRESDIPKTTVQVAEEAIVNAMRVLYYRDARSSRNFSLAIIDKNTGLTFKKNLQVENMKWDFAKDIKGYGTQKILast
1 -107.000[O] KOG0185 20S proteasome, regulatory subunit beta type PSMB4/PRE4  ali  100  1MNHDPFSWGRPADSTYGAYNTQIANAGASPMVNTQQPIVTGTSVISMKYDNGVIIAADNLGSYGSLLRFNGVERLIPVGDNTVVGISGDISDMQHIERLLKDLVTENAYDNPLADAEEALEPSYIFEYLATVMYQRRSKMNPLWNAIIVAGVQSNGDQFLRYVNLLGVTYSSPTLATGFGAHMANPLLRKVVDRESDIPKTTVQVAEEAIVNAMRVLYYRDARSSRNFSLAIIDKNTGLTFKKNLQVENMKWDFAKDIKGYGTQKI 266
2 -79.500[O] KOG0179 20S proteasome, regulatory subunit beta type PSMB1/PRE7  ali follow..  18  1MLSSTAMYSAPGRD-----LGMEPHRAAGPLQLRFSPVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSN-----NKAMTTGAIAAMLSTILYSRR--FFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD.................. 241
3 -76.400[O] KOG0177 20S proteasome, regulatory subunit beta type PSMB2/PRE1  ali follow..  17  2.........................................ECVFGLVGNGFAIVAADTSAVHSILLHKNKEDKIMTLDSHKLVAASGEPGDRVQFTEYVQKNVSLYQFRN-----GIPLSTAAAANFTRGELATAL-RKNPYSVNILMAGYDKEAGASLYYIDYIATLHKVDKGAFGYGSYFSLSTMDRHYR-----SDMSVEEAIELVDKCILEIRSRLVIAPPNFVIKIVDKDGAREYGWRISTAD................. 198
4 -75.200[O] KOG0180 20S proteasome, regulatory subunit beta type PSMB3/PUP3  ali follow..  16  5.....................................EYNGSAVVAMVGKNCFAIASDRRLGVQLQTIATDFQRISKIHDRVFIGLSGLATDVQTLYQRLVFRHKLYQLRE-----ERDMKPETFASLVSAILYEKR--FGPYLCQPVIAGLGDDDKPFICTMDSIGKELAKDFVVSGTASESLYGACEAMYK-----PDMEAEELFETISQALLSSVDRDCLSGWGGHVYIVTPTEIKERILKGRMD.................. 204
5 -74.500[O] KOG0174 20S proteasome, regulatory subunit beta type PSMB6/PSMB9/PRE3  ali follow..  16  10...............................RLKKGEVSLGTSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTP------STETAASVFKELCYENKD---NLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFR-----ENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLFYPDEYEQL................ 215
6 -70.800[O] KOG0173 20S proteasome, regulatory subunit beta type PSMB7/PSMB10/PUP1  ali follow..  14  1MAAVSVYAPPVGGFSFDNCRRNAVLEADAKRGYKLPKVKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLST-----GRLPRVVTANRMLKQMLFRYQG---YIGAALVLGGVDVT-GPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFR-----PDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAV 254
7 -68.100[O] KOG0175 20S proteasome, regulatory subunit beta type PSMB5/PSMB8/PRE2  ali follow..  15  60.............................SHCGIRMDFDHGTTTLGFKYRGGVILCADSRATSGQYIGSQTMRKIVELNDYMLGTLAGGAADCVYWDRVLAKECRLHQLRY-----RKRMTVDTAARIICNISTEYKGM--GLVMGMMLAGFDDE-GPKLIYVDSEGMRSHGQVFSVGSGSPYALGVLDTGYR-----YDLSDQEAYDLARRAIYHATSKDAYSGGIVRLYHIHSEGWRNI-CNTDCSDLHDSYCASGCPGNEKDV 282
8 -63.200[O] KOG0178 20S proteasome, regulatory subunit alpha type PSMA4/PRE9  ali follow..  13  2............ARRYDSRTTIFSPEGRYQVEYAMEAISHAGTCLGILAEDGILLAAECRSTNKLLDSAIPSEKIYRLNDNMVCSVAGITSDANVLTSELRLIAQRYQFSY-----GEVIPCEQLVSHLCDIKYTQYGGKRPFGVSLLYMGWDNKYGYQLYQSDPSGNYGGWKATCIGNNFGAAISMLKQELADK-ENVKLTLADAKDLAIKVLSMTLDTTKLTPEKVEMATLQRVDVYSVLEKPDVEKLIEKYTKV......... 246
9 -58.100[O] COG0638 20S proteasome, alpha and beta subunits  ali follow..  16  5..........PAAMGYDRAITIFSPDGSYQVDYAFEAVKKGWTAIGIKSKSSVVIASEKRKAQS-LLDVDSIEKVFLIDDHVGCSFAGLASDGRVLIDYARNIALQHRLIY-----DEPVSIDYLTKSVADVKYTQHGGVRPFGVALVIAGIDKS-VPKLFMTEPSGQYMPYQAVAIGQGYYTATEFLEKNYK-----EDLNVEETILLALKALSATLKPNELTPNTVEIGYASTQTLFLKMTNEDKNMYLQKL............ 241
10 -57.700[O] COG3484 Predicted proteasome-type protease  ali follow..  12  2.........................................TYCVAMHLADGLVFASDSRTNAGIDHIAT-FRKLFTFERLLVVQTAGNLATSQSVINLLQQRIRRDGASLL-----NVPSVYDATALVAETTREVLAGNTDLSCSFLVGGQIAGGPPALYSIYPQGNFIQATPFLQLGESKYGKPILDRNLT-----FDTPLEQALRCALVSFDSTIRSNLSVGMPLDLLVYHRDSL-ILPEGYRVTEDDAYFSAIRRQWSAG.. 226
11 -55.800[O] KOG0184 20S proteasome, regulatory subunit alpha type PSMA3/PRE10  ali follow..  12  5............GTGYDLSASQFSPDGRFQIDYASKAVEKSGTVIGIRGKDAVVLAVEKIIT-SKLYEPDAGGRIFTIEKNIGMAVAGLVADGNFVADIARQEAANYRQQFEQAIPLKHLCHRVAGYV---HAYTLYSAVRPFGLSIILASWDEVEGPQLYKIEPSGSSFGYFACASGKAKQLAKTEMEKLKM------DMRTDELVESAGEIIYKVHDELKDKDFRFEMGLVGRVGGLHLINPSELTEKARKAGDA......... 241
12 -55.300[O] KOG0181 20S proteasome, regulatory subunit alpha type PSMA2/PRE8  ali follow..  14  2...........ATERYSFSLTTFSPSGKVQLEYALAAVSGGAPSVGIIASNGVVIATENKHK-SPLYEQHSVHRVEMIYNHIGMVYSGMGPDYRLLVKQARKIAQTYYLTYKEPIPVSQLVQRVATLM---QEYTQSGGVRPFGVSLLICGWDND-RPYLYQSDPSGAYFAWKATAMGKNAVNGKTFLEKRYS-----EDLELDDAVHTAILTLKEGFEGK-MTADNIEIGICDQNGF-QRLDPASIKDYLASIP........... 234
13 -55.100[O] KOG0183 20S proteasome, regulatory subunit alpha type PSMA7/PRE6  ali follow..  12  2.............NRYDRAITIFSPDGHFQVEYAQEAVKKGSTAVGVRGKDCIVIGVEKKSI-PALQDDRTIRKIHMIDDHVMLAFAGLSADARVLVDRARIECQSYKLTLEDPVTVAYISRYIANT---KQRFTQSPGRRPFGISMLIGGFDHDGTPRLFKTEPSGAYYEYVANATGRGEKPVREYLEEQYS-----EENTVDEATTLKLVVKSLAQVVPP-GSQNIEIAVMKKVN-QRVLSTEEIEALLKVVETE......... 239
14 -54.700[O] COG5405 ATP-dependent protease HslVU (ClpYQ), peptidase subunit  ali follow..  11  2.........................................TTIVSVRRNGHVVIAGDGQATLGNTVMKGNVKKVRRLYNDVIAGFAGGTADAFTLFELFERKLEMHQGHLV-----KAAVELAKDWRTDRMLRKLE------------ALLAVADETASLIITGNGDVVQPENDLIAIGSGGPYAQAAARAL-----LENTELSAREIAEKALDIAGDICIYTNHFHTIEELSYKA............................. 176
15 -54.600[O] KOG0182 20S proteasome, regulatory subunit alpha type PSMA6/SCL1  ali follow..  12  1.......MSRGSSAGFDRHITIFSPEGRYQVEYAFKAINQGGTSVAVRGKDCAVIVTQKKVP-DKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADI---SQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKK---FDWTFEQTVETAITCLSTVLSID-FKPSEIEVGVVTVENKFRILTEAEIDAHLVALAER......... 245
16 -53.200[O] KOG0176 20S proteasome, regulatory subunit alpha type PSMA5/PUP2  ali follow..  18  5............RTEYDRGVNTFSPEGRFQVEYAIEAIKLGSTAIGVKTKEGVVLAVEKRIT-SPLLEPSSVEKIMEIDDHIGCAMSGLIADARTLVEHARVETQNHRFSYGEPMTVESTTQALCDLALRFGEGEEESMSRPFGVSLLIAGHDEN-GPSLYYTDPSGTFWQCNAKAIGSGSEGADSSLQEQFN-----KDITLQEAETIAVSILKQVMEEK-VTPNNVDIAKVAPA--YHLYTPQEVEAVISRL............ 237
17 -52.400[O] KOG0863 20S proteasome, regulatory subunit alpha type PSMA1/PRE5  ali follow..  10  2...........FRNQYDNDVTVWSPQGRHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELA---AHQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKT---QIPTQRYGRRPYGVGLLIAGYDDM-GPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEF---MECNLNELVKHGLRALRETLPAEQLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERPQRKAQPA. 247
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.